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Literature for peptidase S01.243: lumbrokinase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Stephani,L., Rahayu,P., Retnoningrum,D., Suhartono,M.T., Rachmawati,H. and Tjandrawinata,R.R.<br>Purification and proteomic analysis of potent fibrinolytic enzymes extracted from Lumbricus rubellus<br>Proteome Sci (2023) 21, 8-8. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2022
  2. Metkar,S.K., Girigoswami,A., Bondage,D.D., Shinde,U.G. and Girigoswami,K.<br>The potential of lumbrokinase and serratiopeptidase for the degradation of Abeta 1-42 peptide - an in vitro and in silico approach<br>Int J Neurosci (2022) , 1-12. PubMed  Europe PubMed DOI
    3. 2020
  3. Metkar,S.K., Girigoswami,A., Vijayashree,R. and Girigoswami,K.<br>Attenuation of subcutaneous insulin induced amyloid mass in vivo using Lumbrokinase and Serratiopeptidase<br>Int J Biol Macromol (2020) 163, 128-134. PubMed  Europe PubMed DOI
    4. 2019
  4. Liao,J., Ren,X., Yang,B., Li,H., Zhang,Y. and Yin,Z.<br>Targeted thrombolysis by using c-RGD-modified N,N,N-trimethyl chitosan nanoparticles loaded with lumbrokinase<br>Drug Dev Ind Pharm (2019) 45, 88-95. PubMed  Europe PubMed DOI  U
    5. 2018
  5. Akazawa,S.I., Tokuyama,H., Sato,S., Watanabe,T., Shida,Y. and Ogasawara,W.<br>High-pressure tolerance of earthworm fibrinolytic and digestive enzymes<br>J Biosci Bioeng (2018) 125, 155-159. PubMed  Europe PubMed DOI
  6. Hu,B., Yan,Y., Tong,F., Xu,L., Zhu,J., Xu,G. and Shen,R.<br>Lumbrokinase/paclitaxel nanoparticle complex: potential therapeutic applications in bladder cancer<br>Int J Nanomedicine (2018) 13, 3625-3640. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wang,Y.H., Li,S.A., Huang,C.H., Su,H.H., Chen,Y.H., Chang,J.T. and Huang,S.S.<br>Sirt1 activation by post-ischemic treatment with lumbrokinase protects against myocardial ischemia-reperfusion injury<br>Front Pharmacol (2018) 9, 636-636. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2017
  8. Dickey,A., Wang,N., Cooper,E., Tull,L., Breedlove,D., Mason,H., Liu,D. and Wang,K.Y.<br>Transient expression of lumbrokinase (PI239) in tobacco (Nicotiana tabacum) using a geminivirus-based single replicon system dissolves fibrin and blood clots<br>Evid Based Complement Alternat Med (2017) 2017, 6093017-6093017. PubMed  Europe PubMed DOI  PMC  EPMC  E
  9. Jin,M., Jin,G., Huang,W. and Gao,Z.<br>PEGylation of lumbrokinase improves pharmacokinetic profile and enhances antithrombotic effect in a rat carotid artery thrombosis model<br>Mol Med Rep (2017) 16, 4909-4914. PubMed  Europe PubMed DOI  U
  10. Verma,M.K. and Pulicherla,K.K.<br>Broad substrate affinity and catalytic diversity of fibrinolytic enzyme from Pheretima posthumous. Purification and molecular characterization study<br>Int J Biol Macromol (2017) 95, 1011-1021. PubMed  Europe PubMed DOI
    11. 2015
  11. Fu,Y.T., Sheu,S.Y., Chen,Y.S., Chen,K.Y. and Yao,C.H.<br>Porous gelatin/tricalcium phosphate/genipin composites containing lumbrokinase for bone repair<br>Bone (2015) 78, 15-22. PubMed  Europe PubMed DOI  U
  12. Lee,H.C., Hsu,Y.M., Tsai,C.C., Ke,C.J., Yao,C.H. and Chen,Y.S.<br>Improved peripheral nerve regeneration in streptozotocin-induced diabetic rats by oral lumbrokinase<br>Am J Chin Med (2015) 43, 215-230. PubMed  Europe PubMed DOI
    13. 2014
  13. Guan,C., Ji,J., Jin,C., Wang,G., Li,X. and Guan,W.<br>Expression of cholera toxin B subunit-lumbrokinase in edible sunflower seeds-the use of transmucosal carrier to enhance its fusion protein's effect on protection of rats and mice against thrombosis<br>Biotechnol Prog (2014) 30, 1029-1039. PubMed  Europe PubMed DOI
    14. 2013
  14. Cao,Y.J., Zhang,X., Wang,W.H., Zhai,W.Q., Qian,J.F., Wang,J.S., Chen,J., You,N.X., Zhao,Z., Wu,Q.Y., Xu,Y., Yuan,L., Li,R.X. and Liu,C.F.<br>Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel-group and controlled clinical trial<br>Chin Med J (Engl) (2013) 126, 4060-4065. PubMed  Europe PubMed DOI  U
  15. Joo,H.S., Ra,K.S., Park,H.S. and Choi,J.W.<br>Molecular cloning and functional expression of a fibrinolytic protease gene from the polychaeta, Periserrula leucophryna<br>Biotechnol Bioprocess Eng (2013) 18, 209-217. DOI
  16. Wang,K.Y., Tull,L., Cooper,E., Wang,N. and Liu,D.<br>Recombinant protein production of earthworm lumbrokinase for potential antithrombotic application<br>Evid Based Complement Alternat Med (2013) 2013, 783971-783971. PubMed  Europe PubMed DOI  PMC  EPMC  E
    17. 2012
  17. Wang,Y.Y., Fu,W.L., Wang,M., Zou,M.J., Xu,T., Wang,J.X., Zhang,H. and Xu,D.G.<br>[Quantitative method for detection of plasma lumbrokinase content and its assessment]<br>Zhongguo Shi Yan Xue Ye Xue Za Zhi (2012) 20, 1492-1495. PubMed  Europe PubMed  A
  18. Zhou,Y. and He,R.Q.<br>Earthworm fibrinolytic enzymes<br>[ISSN:978-0-12-407742-3] (2012) 3, 2953-2958. DOI
    19. 2011
  19. Pan,R., Zhou,Y., He,H.J. and He,R.Q.<br>An enzyme from the earthworm Eisenia fetida is not only a protease but also a deoxyribonuclease<br>Biochem Biophys Res Commun (2011) 407, 113-117. PubMed  Europe PubMed DOI
  20. Sharma,A., Sonah,H., Deshmukh,R.K., Gupta,N.K., Singh,N.K. and Sharma,T.R.<br>Cloning of fibrinolytic protease-0 (Efp-0) gene from diverse earthworm individuals<br>Indian J Biotechnol (2011) 10, 270-273.
  21. Ueda,M., Yamashita,T., Nakazawa,M., Miyatake,K., Ohki,S., Sakaguchi,M. and Inouye,K.<br>Purification and characterization of a new serine protease (EF-SP2) with anti-plant viral activity from Eisenia foetida: analysis of anti-plant viral activity of EF-SP2<br>Process Biochem (2011) 46, 1711-1716. DOI
    22. 2010
  22. Xu,Z.R., Yang,Y.M., Gui,Q.F., Zhang,L.N. and Hu,L.<br>Expression, purification, and characterization of recombinant lumbrokinase PI239 in Escherichia coli<br>Protein Expr Purif (2010) 69, 198-203. PubMed  Europe PubMed DOI  E
  23. Yan,X.M., Kim,C.H., Lee,C.K., Shin,J.S., Cho,I.H. and Sohn,U.D.<br>Intestinal absorption of fibrinolytic and proteolytic lumbrokinase extracted from earthworm, Eisenia andrei<br>Korean J Physiol Pharmacol (2010) 14, 71-75. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2007
  24. Zhao,J., Xiao,R., He,J., Pan,R., Fan,R., Wu,C., Liu,X., Liu,Y. and He,R.Q.<br>In situ localization and substrate specificity of earthworm protease-II and protease-III-1 from Eisenia fetida<br>Int J Biol Macromol (2007) 40, 67-75. PubMed  Europe PubMed DOI
  25. Zhao,J., Pan,R., He,J., Liu,Y., Li,D.F. and He,R.Q.<br>Eisenia fetida protease-III-1 functions in both fibrinolysis and fibrogenesis<br>J Biomed Biotechnol (2007) 2007, 97654-97654. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2006
  26. Zhao,X.Y., Gao,S., Cui,D.L. and Geng,F.T.<br>[In silico cloning of EfP-0, a novel earthworm fibrinolytic enzyme gene and verification of its coding region by RT-PCR]<br>Sheng Wu Gong Cheng Xue Bao (2006) 22, 897-901. PubMed  Europe PubMed DOI
    27. 2005
  27. [YEAR:6-5-2005]Wang,F., Wang,C., Li,M., Zhang,J.P., Gui,L.L., An,X.M. and Chang,W.R.<br>Crystal structure of earthworm fibrinolytic enzyme component B: a novel, glycosylated two-chained trypsin<br>J Mol Biol (6-5-2005) 348, 671-685. PubMed  Europe PubMed DOI  S
    28. 2004
  28. [YEAR:30-9-2004]Cho,I.H., Choi,E.S. and Lee,H.H.<br>Molecular cloning, sequencing, and expression of a fibrinolytic serine-protease gene from the earthworm Lumbricus rubellus<br>J Biochem Mol Biol (30-9-2004) 37, 574-581. PubMed  Europe PubMed
  29. Cho,I.H., Choi,E.S., Lim,H.G. and Lee,H.H.<br>Purification and characterization of six fibrinolytic serine-proteases from earthworm Lumbricus rubellus<br>J Biochem Mol Biol (2004) 37, 199-205. PubMed  Europe PubMed
  30. Dong,G.Q., Yuan,X.L., Shan,Y.J., Zhao,Z.H., Chen,J.P. and Cong,Y.W.<br>Molecular cloning and characterization of cDNA encoding fibrinolytic enzyme-3 from earthworm Eisenia foetida<br>Acta Biochim Biophys Sin (Shanghai) (2004) 36, 303-308. PubMed  Europe PubMed
  31. Nakajima,N., Ishihara,K. and Sugimoto,M.<br>Earthworm fibrinolytic enzymes<br>[ISSN:0-12-079610-4] (2004) 2, 1689-1691.  V
    32. 2002
  32. Nakajima,N., Ishihara,K., Sugimoto,M., Nakahara,T. and Tsuji,H.<br>Further stabilization of earthworm serine protease by chemical modification and immobilization<br>Biosci Biotechnol Biochem (2002) 66, 2739-2742. PubMed  Europe PubMed DOI
    33. 2001
  33. [YEAR:15-6-2001]Fan,Q., Wu,C., Li,L., Fan,R., Wu,C., Hou,Q.M. and He,R.Q.<br>Some features of intestinal absorption of intact fibrinolytic enzyme III-1 from Lumbricus rubellus<br>Biochim Biophys Acta (15-6-2001) 1526, 286-292. PubMed  Europe PubMed DOI
  34. Sugimoto,M. and Nakajima,N.<br>Molecular cloning, sequencing, and expression of cDNA encoding serine protease with fibrinolytic activity from earthworm<br>Biosci Biotechnol Biochem (2001) 65, 1575-1580. PubMed  Europe PubMed DOI
    35. 2000
  35. Jin,L., Jin,H., Zhang,G. and Xu,G.<br>Changes in coagulation and tissue plasminogen activator after the treatment of cerebral infarction with lumbrokinase<br>Clin Hemorheol Microcirc (2000) 23, 213-218. PubMed  Europe PubMed
    36. 1999
  36. Nakajima,N., Sugimoto,M., Ishihara,K., Nakamura,K. and Hamada,H.<br>Further characterization of earthworm serine proteases: cleavage specificity against peptide substrates and on autolysis<br>Biosci Biotechnol Biochem (1999) 63, 2031-2033. PubMed  Europe PubMed DOI
  37. Park,Y., Ryu,E., Kim,H., Jeong,J., Kim,J., Shim,J., Jeon,S., Jo,Y., Kim,W. and Min,B.<br>Characterization of antithrombotic activity of lumbrokinase-immobilized polyurethane valves in the total artificial heart<br>Artif Organs (1999) 23, 210-214. PubMed  Europe PubMed DOI
    38. 1996
  38. Nakajima,N., Ishihara,K., Sugimoto,M., Sumi,H., Mikuni,K. and Hamada,H.<br>Chemical modification of earthworm fibrinolytic enzyme with human serum albumin fragment and characterization of the protease as a therapeutic enzyme<br>Biosci Biotechnol Biochem (1996) 60, 293-300. PubMed  Europe PubMed DOI
    39. 1995
  39. Ryu,G.H., Han,D.K., Park,S., Kim,M., Kim,Y.H. and Min,B.<br>Surface characteristics and properties of lumbrokinase-immobilized polyurethane<br>J Biomed Mater Res (1995) 29, 403-409. PubMed  Europe PubMed DOI
    40. 1994
  40. Ryu,G.H., Park,S., Kim,M., Han,D.K., Kim,Y.H. and Min,B.<br>Antithrombogenicity of lumbrokinase-immobilized polyurethane<br>J Biomed Mater Res (1994) 28, 1069-1077. PubMed  Europe PubMed DOI
    41. 1993
  41. Kim,J.S., Kang,J.K., Chang,H.C., Lee,M., Kim,G.S., Lee,D.K., Kim,S.T., Kim,M. and Park,S.<br>The thrombolytic effect of lumbrokinase is not as potent as urokinase in a rabbit cerebral embolism model<br>J Korean Med Sci (1993) 8, 117-120. PubMed  Europe PubMed
  42. Nakajima,N., Mihara,H. and Sumi,H.<br>Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus<br>Biosci Biotechnol Biochem (1993) 57, 1726-1730. PubMed  Europe PubMed DOI
  43. Ryu,G.H., Park,S., Han,D.K., Kim,Y.H. and Min,B.<br>Antithrombotic activity of a lumbrokinase immobilized polyurethane surface<br>ASAIO J (1993) 39, M314-M318. PubMed  Europe PubMed DOI
    44. 1991
  44. Mihara,H., Sumi,H., Yoneta,T., Mizumoto,H., Ikeda,R., Seiki,M. and Maruyama,M.<br>A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus<br>Jpn J Physiol (1991) 41, 461-472. PubMed  Europe PubMed

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