Literature for peptidase S01.233: plasmin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Pirillo,E., Freenor,V., Wamba,B.E.N., Bhatnagar,S., Mondal,T. and Tushir-Singh,J. An evolutionary T119R substitution in the macaque T-cell immunoreceptor TIGIT enables proteolytic shedding and reveals clinical antibody vulnerabilities J Biol Chem (2025) , 110962-110962. PubMed Europe PubMed DOI

2024

Al-Horani,R.A. and Aliter,K.F. Triple Action of Lignosulfonic Acid Sodium: Anti-protease, Antioxidant, and Anti-inflammatory Effects of a Polymeric Heparin Mimetic Med Chem (2024) 20, 414-421. PubMed Europe PubMed DOI I
Al-Horani,R.A. Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases Heliyon (2024) 10, e28017-e28017. PubMed Europe PubMed DOI PMC EPMC I
Barrett,C.D., Moore,P.K., Moore,E.E., Moore,H.B., Chandler,J.G., Siddiqui,H., Maginot,E.R., Sauaia,A., Perez-Calatayud,A.A., Buesing,K., Wang,J., Davila-Chapa,C., Hershberger,D., Douglas,I., Pieracci,F.M. and Yaffe,M.B. Plasminogen Degradation by Neutrophil Elastase in Pleural Infection, Not High Plasminogen Activator Inhibitor-1 (PAI-1), is the Cause of Intrapleural Lytic Failure Chest (2024) PubMed Europe PubMed DOI
Bharadwaj,A.G., Okura,G.C., Woods,J.W., Allen,E.A., Miller,V.A., Kempster,E., Hancock,M.A., Gujar,S., Slibinskas,R. and Waisman,D.M. Identification and characterization of calreticulin as a novel plasminogen receptor J Biol Chem (2024) 300, 105465-105465. PubMed Europe PubMed DOI PMC EPMC
Brito-Robinson,T., Ayinuola,Y.A., Ploplis,V.A. and Castellino,F.J. Plasminogen missense variants and their involvement in cardiovascular and inflammatory disease Front Cardiovasc Med (2024) 11, 1406953-1406953. PubMed Europe PubMed DOI PMC EPMC
Dai,X., Yang,J., Lv,L., Wang,C. and Bian,L. Molecular recognition and binding between human plasminogen Kringle 5 and alpha-chain of human complement component C3b by frontal chromatography and dynamics simulation J Chromatogr A (2024) 1718, 464673-464673. PubMed Europe PubMed DOI
Dickeson,S.K., Kumar,S., Sun,M.F., Litvak,M., He,T.Z., Phillips,D.R., Roberts,E.T., Feener,E.P., Law,R.H.P. and Gailani,D. A mechanism for hereditary angioedema caused by a methionine-379-to-lysine substitution in kininogens Blood (2024) 143, 641-650. PubMed Europe PubMed DOI PMC EPMC
Otmani,H.E., Vanhoorelbeke,K. and Tersteeg,C. Improving our understanding on the clinical role of plasmin-mediated von Willebrand factor degradation Curr Opin Hematol (2024) 31, 245-250. PubMed Europe PubMed DOI V
Tang,D., Khakzad,H., Hjortswang,E., Malmstrom,L., Ekstrom,S., Happonen,L. and Malmstrom,J. Streptolysin O accelerates the conversion of plasminogen to plasmin Nat Commun (2024) 15, 10212-10212. PubMed Europe PubMed DOI PMC EPMC
Uguen,K., Frey,T., Muthaffar,O., Decarie,J.C., Ameziane,N., Boissel,S., Baradaran-Heravi,Y., Rauch,A., Oprea,G., Rad,A., Steindl,K. and Michaud,J.L. Loss of tissue-type plasminogen activator causes multiple developmental anomalies Brain Commun (2024) 6, fcae408-fcae408. PubMed Europe PubMed DOI PMC EPMC
Vrzalova,A. and Vrzal,R. Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation Biochimie (2024) PubMed Europe PubMed DOI V

2023

Afosah,D.K., Fayyad,R.M., Puliafico,V.R., Merrell,S., Langmia,E.K., Diagne,S.R., Al-Horani,R.A. and Desai,U.R. Homogeneous, Synthetic, Non-Saccharide Glycosaminoglycan Mimetics as Potent Inhibitors of Human Cathepsin G Biomolecules (2023) 13 PubMed Europe PubMed DOI PMC EPMC I
Ferreira,G.C., Bomediano Camillo,L.M. and Sasaki,S.D. Structural and functional properties of rBmTI-A: A Kunitz-BPTI serine protease inhibitor with therapeutical potential Biochimie (2023) 204, 7- PubMed Europe PubMed DOI
Kaur,P., Sethi,D., Hade,M.D., Kaur,J. and Dikshit,K.L. C-terminal lysine residues enhance plasminogen activation by inducing conformational flexibility and stabilization of activator complex of staphylokinase with plasmin Arch Biochem Biophys (2023) 743, 109671-109671. PubMed Europe PubMed DOI
Moore-Lotridge,S.N., Hajdu,K.S., Hou,B.Q., Gibson,B.H.Y. and Schoenecker,J.G. Maintaining the balance: the critical role of plasmin activity in orthopedic surgery injury response J Thromb Haemost (2023) 21, 2653-2665. PubMed Europe PubMed DOI V
Yang,J., Cha,L., Wang,Y., Zhang,Q., Tang,X., Shao,J. and Duan,Z. L-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis Nat Prod Bioprospect (2023) 13, 48-48. PubMed Europe PubMed DOI PMC EPMC

2022

Bryk-Wiazania,A.H., Cysewski,D., Oclon,E. and Undas,A. Mass-spectrometric identification of oxidative modifications in plasma-purified plasminogen: Association with hypofibrinolysis in patients with acute pulmonary embolism Biochem Biophys Res Commun (2022) 621, 53-58. PubMed Europe PubMed DOI
Loef,E.J., Sheppard,H.M., Birch,N.P. and Dunbar,P.R. Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses J Biol Chem (2022) 298, 102112-102112. PubMed Europe PubMed DOI PMC EPMC
Mehner,C., Hockla,A., Coban,M., Madden,B., Estrada,R., Radisky,D.C. and Radisky,E.S. Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma J Biol Chem (2022) 298, 102146-102146. PubMed Europe PubMed DOI PMC EPMC
Pascini,T.V., Jeong,Y.J., Huang,W., Pala,Z.R., Sa,J.M., Wells,M.B., Kizito,C., Sweeney,B., Alves E Silva, Andrew,D.J., Jacobs-Lorena,M. and Vega-Rodriguez,J. Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission Nat Commun (2022) 13, 2949-2949. PubMed Europe PubMed DOI PMC EPMC
Vasilyeva,A., Yurina,L., Ivanov,V., Azarova,D., Gavrilina,E., Indeykina,M., Bugrova,A., Kononikhin,A., Nikolaev,E. and Rosenfeld,M. The effect of hypochlorite- and peroxide-induced oxidation of plasminogen on damage to the structure and biological activity Int J Biol Macromol (2022) 206, 64-73. PubMed Europe PubMed DOI

2021

Choudhary,K., Patel,P.K., Are,V.N., Makde,R.D. and Hajela,K. Mannose-binding lectin-associated serine protease-1 cleaves plasminogen and plasma fibronectin: prefers plasminogen over known fibrinogen substrate Blood Coagul Fibrinolysis (2021) 32, 504-512. PubMed Europe PubMed DOI
Friedrich,C., Neugebauer,L., Zamora,M., Robles,J.P., Martinez de la Escalera,G., Clapp,C., Bertsch,T. and Triebel,J. Plasmin generates vasoinhibin-like peptides by cleaving prolactin and placental lactogen Mol Cell Endocrinol (2021) 538, 111471-111471. PubMed Europe PubMed DOI
Heestermans,M., Naudin,C., Mailer,R.K., Konrath,S., Klaetschke,K., Jamsa,A., Frye,M., Deppermann,C., Pula,G., Kuta,P., Friese,M.A., Gelderblom,M., Sickmann,A., Preston,R.J.S., Nofer,J.R., Rose-John,S., Butler,L.M., Salomon,O., Stavrou,E.X. and Renne,T. Identification of the factor XII contact activation site enables sensitive coagulation diagnostics Nat Commun (2021) 12, 5596-5596. PubMed Europe PubMed DOI PMC EPMC
Ismail,A.A., Shaker,B.T. and Bajou,K. The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis Int J Mol Sci (2021) 23 PubMed Europe PubMed DOI PMC EPMC
Kryza,T., Khan,T., Lovell,S., Harrington,B.S., Yin,J., Porazinski,S., Pajic,M., Koistinen,H., Rantala,J.K., Dreyer,T., Magdolen,V., Reuning,U., He,Y., Tate,E.W. and Hooper,J.D. Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1 Nat Chem Biol (2021) PubMed Europe PubMed DOI
Kunnapuu,J., Bokharaie,H. and Jeltsch,M. Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs Biology (Basel) (2021) 10 PubMed Europe PubMed DOI PMC EPMC
Miszta,A., Huskens,D., Donkervoort,D., Roberts,M.J.M., Wolberg,A.S. and de Laat,B. Assessing Plasmin Generation in Health and Disease Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC V
Pala,Z.R., Ernest,M., Sweeney,B., Jeong,Y.J., Pascini,T.V., Alves E Silva and Vega-Rodriguez,J. Beyond cuts and scrapes: plasmin in malaria and other vector-borne diseases Trends Parasitol (2021) PubMed Europe PubMed DOI V
Walvekar,V.A., Ramesh,K., Jobichen,C., Kannan,M., Sivaraman,J., Kini,R.M. and Mok,Y.K. Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor Protein Sci (2021) PubMed Europe PubMed DOI
Wang,M., Xie,Y. and Qin,D. Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases Brain Res Bull (2021) 166, 172-184. PubMed Europe PubMed DOI
Yazgan,N.N., Bulat,T., Topcu,A., Dudak,F.C., Boyaci,I.H. and Tamer,U. Surface-enhanced Raman scattering-based detection of plasmin activity by specific peptide substrate Food Chem (2021) 372, 131235-131235. PubMed Europe PubMed DOI

2020

Ayinuola,Y.A., Brito-Robinson,T., Ayinuola,O., Beck,J.E., Cruz-Topete,D., Lee,S.W., Ploplis,V.A. and Castellino,F.J. Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence J Biol Chem (2020) PubMed Europe PubMed DOI
Baghban,R., Farajnia,S., Ghasemi,Y., Hoseinpoor,R., Safary,A., Mortazavi,M. and Zarghami,N. Mutational Analysis of Ocriplasmin to Reduce Proteolytic and Autolytic Activity in Pichia pastoris Biol Proced Online (2020) 22, 25-25. PubMed Europe PubMed DOI PMC EPMC
Brunet,J.G., Sharma,T., Tasneem,S., Liang,M., Wilson,M.D., Rivard,G.E. and Hayward,C.P.M. Thrombin generation abnormalities in Quebec platelet disorder Int J Lab Hematol (2020) , e13302-e13302. PubMed Europe PubMed DOI I
Heissig,B., Salama,Y., Takahashi,S., Osada,T. and Hattori,K. The multifaceted role of plasminogen in inflammation Cell Signal (2020) 75, 109761-109761. PubMed Europe PubMed DOI PMC EPMC V
Klaassen,K., Stankovic,B., Zukic,B., Kotur,N., Gasic,V., Pavlovic,S. and Stojiljkovic,M. Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection Infect Genet Evol (2020) 84, 104498-104498. PubMed Europe PubMed DOI PMC EPMC
Marceau,F., Rivard,G.E., Gauthier,J.M., Binkley,K.E., Bonnefoy,A., Boccon-Gibod,I., Bouillet,L., Picard,M., Levesque,G., Elfassy,H.L., Bachelard,H., Hebert,J. and Bork,K. Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants Front Med (Lausanne) (2020) 7, 358-358. PubMed Europe PubMed DOI PMC EPMC I
Medcalf,R.L., Keragala,C.B. and Myles,P.S. Fibrinolysis and COVID-19: A plasmin paradox J Thromb Haemost (2020) PubMed Europe PubMed DOI PMC EPMC
Miles,L.A., Vago,J.P., Sousa,L.P. and Parmer,R.J. Functions of the Plasminogen Receptor, Plg-RKT J Thromb Haemost (2020) PubMed Europe PubMed DOI V
Moraes,C.T.P., Longo,J., Silva,L.B., Pimenta,D.C., Carvalho,E., Morone,M.S.L.C., da Ros,N., Serrano,S.M.T., Santos,A.C.M., Piazza,R.M.F., Barbosa,A.S. and Elias,W.P. Surface Protein Dispersin of Enteroaggregative Escherichia coli Binds Plasminogen That Is Converted Into Active Plasmin Front Microbiol (2020) 11, 1222-1222. PubMed Europe PubMed DOI PMC EPMC
Pedersen,N.B., Stolberg,C.R., Mundbjerg,L.H., Juhl,C.B., Gram,B., Funch-Jensen,P., de Maat,M.P.M., Munster,A.B. and Bladbjerg,E.M. Reductions in plasmin inhibitor and fibrinogen predict the improved fibrin clot lysis 6 months after obesity surgery Clin Obes (2020) , e12397-e12397. PubMed Europe PubMed DOI
Sanda,T., Yoshimura,M., Hyodo,K., Ishii,H. and Yamashita,T. Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE(-/-)-LDLR(-/-) Double-Knockout Mice Korean Circ J (2020) 50, 804-816. PubMed Europe PubMed DOI I
Seth,S., Batra,J. and Srinivasan,S. COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response Front Mol Biosci (2020) 7, 215-215. PubMed Europe PubMed DOI PMC EPMC V
Steinmetzer,T., Pilgram,O., Wenzel,B.M. and Wiedemeyer,S.J.A. Fibrinolysis inhibitors: potential drugs for the treatment and prevention of bleeding J Med Chem (2020) 63, 1445-1472. PubMed Europe PubMed DOI I
Suzuki,Y., Sano,H., Mochizuki,L., Honkura,N. and Urano,T. Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system Blood Adv (2020) 4, 5501-5511. PubMed Europe PubMed DOI PMC EPMC
Thierry,A.R. Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19 Physiol Rev (2020) 100, 1597-1598. PubMed Europe PubMed DOI PMC EPMC
Vadivel,K., Zaiss,A.K., Kumar,Y., Fabian,F.M., Ismail,A.E.A., Arbing,M.A., Buchholz,W.G., Velander,W.H. and Bajaj,S.P. Enhanced Antifibrinolytic Efficacy of a Plasmin-Specific Kunitz-Inhibitor (60-Residue Y11T/L17R with C-Terminal IEK) of Human Tissue Factor Pathway Inhibitor Type-2 Domain1 J Clin Med (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Weihs,F., Peh,A. and Dacres,H. A red-shifted bioluminescence resonance energy transfer (BRET) biosensing system for rapid measurement of plasmin activity in human plasma Anal Chim Acta (2020) 1102, 99-108. PubMed Europe PubMed DOI A

2019

Barbosa da Cruz,D., Helms,J., Aquino,L.R., Stiel,L., Cougourdan,L., Broussard,C., Chafey,P., Ries-Kautt,M., Meziani,F., Toti,F., Gaussem,P. and Angles-Cano,E. DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma FASEB J (2019) 33, 14270-14280. PubMed Europe PubMed DOI
Swedberg,J.E., Wu,G., Mahatmanto,T., Durek,T., Caradoc-Davies,T.T., Whisstock,J.C., Law,R.H.P. and Craik,D.J. Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold attenuate fibrinolysis in plasma J Med Chem (2019) 62, 552-560. PubMed Europe PubMed DOI
Trinh,T.H.T., Kim,J., Lee,C.H. and Ryou,C. Non-ionic detergents Nonidet P-40 and Triton X-100 increase enzymatic activity of plasmin Biochem Biophys Res Commun (2019) 512, 314-318. PubMed Europe PubMed DOI
Wu,G., Quek,A.J., Caradoc-Davies,T.T., Ekkel,S.M., Mazzitelli,B., Whisstock,J.C. and Law,R.H.P. Structural studies of plasmin inhibition Biochem Soc Trans (2019) 47, 541-557. PubMed Europe PubMed DOI I
Zhao,T., Houng,A. and Reed,G.L. Termination of bleeding by a specific anticatalytic antibody against plasmin J Thromb Haemost (2019) 17, 1461-1469. PubMed Europe PubMed DOI

2018

Clark,C.C., Mebius,M.M., de Maat,S., Tielens,A.G.M., DE Groot,P.G., Urbanus,R.T., Fijnheer,R., Hazenberg,B.P.C., van Hellemond,J.J. and Maas,C. Truncation of ADAMTS13 by plasmin enhances its activity in plasma Thromb Haemost (2018) 118, 471-479. PubMed Europe PubMed DOI
Nguyen,N.T.T., Rottgerding,F., Devraj,G., Lin,Y.P., Koenigs,A. and Kraiczy,P. The complement binding and inhibitory protein CbiA of Borrelia miyamotoi degrades extracellular matrix components by interacting with plasmin(ogen) Front Cell Infect Microbiol (2018) 8, 23-23. PubMed Europe PubMed DOI PMC EPMC

2017

Draxler,D.F., Sashindranath,M. and Medcalf,R.L. Plasmin: a modulator of immune function Semin Thromb Hemost (2017) 43, 143-153. PubMed Europe PubMed DOI
Law,R.H.P., Wu,G., Leung,E.W.W., Hidaka,K., Quek,A.J., Caradoc-Davies,T.T., Jeevarajah,D., Conroy,P.J., Kirby,N.M., Norton,R.S., Tsuda,Y. and Whisstock,J.C. X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors Blood Adv (2017) 1, 766-771. PubMed Europe PubMed DOI PMC EPMC S I
Schmidt,T.C., Eriksson,P.O., Gustafsson,D., Cosgrove,D., Frolund,B. and Bostrom,J. Discovery and evaluation of anti-fibrinolytic plasmin inhibitors derived from 5-(4-piperidyl)isoxazol-3-ol (4-PIOL) J Chem Inf Model (2017) 57, 1703-1714. PubMed Europe PubMed DOI I
Shimazu,H., Munakata,S., Tashiro,Y., Salama,Y., Dhahri,D., Eiamboonsert,S., Ota,Y., Onoda,H., Tsuda,Y., Okada,Y., Nakauchi,H., Heissig,B. and Hattori,K. Pharmacological targeting of plasmin prevents lethality in a murine model of macrophage activation syndrome Blood (2017) 130, 59-72. PubMed Europe PubMed DOI T
Yang,C., Wang,L., Zhang,H., Yi,Q., Wang,L., Wang,H. and Song,L. The first CUB-domain containing serine protease from Chlamys farreri which might be involved in larval development and immune response Dev Comp Immunol (2017) 76, 163-168. PubMed Europe PubMed DOI
Yuan,Y., Zajicek,J., Qiu,C., Chandrahas,V., Lee,S.W., Ploplis,V.A. and Castellino,F.J. Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen J Biol Chem (2017) 292, 15016-15027. PubMed Europe PubMed DOI
Yue,S.-L., Zhou,Z.-J., Peng,Y., Lin,L.-Z., Li,T.-J., Xing,Y.-T., Wang,F.-F., Li,C.-S. and Hu,Y. Development and verification of dynamic chromogenic method for determination of human plasmin activity Chin J Biol (2017) 30, 74-78. A

2016

Chen,Y.W., Yin,S., Lai,Y.J., Johnson,M.D. and Lin,C.Y. Plasminogen-dependent matriptase activation accelerates plasmin generation by differentiating primary human keratinocytes J Invest Dermatol (2016) 136, 1210-1218. PubMed Europe PubMed DOI
Gonzalez-Miguel,J., Siles-Lucas,M., Kartashev,V., Morchon,R. and Simon,F. Plasmin in parasitic chronic infections: friend or foe? Trends Parasitol (2016) 32, 325-335. PubMed Europe PubMed DOI
Hidaka,K., Gohda,K., Teno,N., Wanaka,K. and Tsuda,Y. Active site-directed plasmin inhibitors: extension on the P2 residue Bioorg Med Chem (2016) 24, 545-553. PubMed Europe PubMed DOI I
Hinkes,S., Wuttke,A., Saupe,S.M., Ivanova,T., Wagner,S., Knorlein,A., Heine,A., Klebe,G. and Steinmetzer,T. Optimization of cyclic plasmin inhibitors: from benzamidines to benzylamines J Med Chem (2016) 59, 6370-6386. PubMed Europe PubMed DOI I
Kakizoe,Y., Miyasato,Y., Onoue,T., Nakagawa,T., Hayata,M., Uchimura,K., Morinaga,J., Mizumoto,T., Adachi,M., Miyoshi,T., Sakai,Y., Tomita,K., Mukoyama,M. and Kitamura,K. A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity J Pharmacol Sci (2016) 132, 145-153. PubMed Europe PubMed DOI I
Khan,M.A. and Haller,J.A. Ocriplasmin for treatment of vitreomacular traction: an update Ophthalmol Ther (2016) 5, 147-159. PubMed Europe PubMed DOI U
Lee,Y.S., Wang,N.K., Chen,Y.P., Chen,K.J., Hwang,Y.S., Lai,C.C. and Wu,W.C. Plasmin enzyme-assisted vitrectomy in pediatric patients with vitreoretinal diseases Ophthalmic Res (2016) 56, 193-201. PubMed Europe PubMed DOI U
Leung,L.L. and Morser,J. Plasmin as a complement C5 convertase EBioMedicine (2016) 5, 20-21. PubMed Europe PubMed DOI PMC EPMC
Maleki,A., Tohidi-Zand,S.R., Amirizadeh,N., Dehghan-Haghighi,J., Zanjani,H., Arish,M., Salari,A.M., Mirhosseini,S.M. and Abrishami,M. Intravitreal autologous plasmin prepared by urokinase for vitreolysis: a pilot study Eur J Ophthalmol (2016) 26, 67-70. PubMed Europe PubMed DOI
Morescalchi,F., Gambicorti,E., Duse,S., Costagliola,C. and Semeraro,F. From the analysis of pharmacologic vitreolysis to the comprehension of ocriplasmin safety Expert Opin Drug Saf (2016) 15, 1267-1278. PubMed Europe PubMed DOI U
Poturnayova,A., Karpisova,I., Castillo,G., Mezo,G., Kocsis,L., Csampai,A., Keresztes,Z. and Hianik,T. Detection of plasmin based on specific peptide substrate using acoustic transducer Sens Actuators, B Chem (2016) 223, 591-598. DOI A

2015

Al-Horani,R.A., Karuturi,R., White,D.T. and Desai,U.R. Plasmin regulation through allosteric, sulfated, small molecules Molecules (2015) 20, 608-624. PubMed Europe PubMed DOI
Alves,N.J. and Kline,J.A. Comparative study on the inhibition of plasmin and delta-plasmin via benzamidine derivatives Biochem Biophys Res Commun (2015) 457, 358-362. PubMed Europe PubMed DOI I
Castillo,G., Pribransky,K., Mezo,G., Kocsis,L., Csampai,A., Nemeth,K., Keresztes,Z. and Hianik,T. Electrochemical and photometric detection of plasmin by specific peptide substrate Electroanalysis (2015) 27, 789-798. DOI A
Foley,J.H., Peterson,E.A., Lei,V., Wan,L.W., Krisinger,M.J. and Conway,E.M. Interplay between fibrinolysis and complement: plasmin cleavage of iC3b modulates immune responses J Thromb Haemost (2015) 13, 610-618. PubMed Europe PubMed DOI
Gonzalez,T., Gaultney,R.A., Floden,A.M. and Brissette,C.A. Escherichia coli lipoprotein binds human plasminogen via an intramolecular domain Front Microbiol (2015) 6, 1095-1095. PubMed Europe PubMed DOI PMC EPMC
Khoshnevis,M. and Sebag,J. Pharmacologic vitreolysis with Ocriplasmin: rationale for use and therapeutic potential in vitreo-retinal disorders BioDrugs (2015) 29, 103-112. PubMed Europe PubMed DOI U
Liu,R., Zhao,B., Zhang,Y., Gu,J., Yu,M., Song,H., Yu,M. and Mo,W. High-level expression, purification, and enzymatic characterization of truncated human plasminogen (Lys531-Asn791) in the methylotrophic yeast Pichia pastoris BMC Biotechnol (2015) 15, 50-50. PubMed Europe PubMed DOI PMC EPMC E
Oudart,J.B., Brassart-Pasco,S., Vautrin,A., Sellier,C., Machado,C., Dupont-Deshorgue,A., Brassart,B., Baud,S., Dauchez,M., Monboisse,J.C., Harakat,D., Maquart,F.X. and Ramont,L. Plasmin releases the anti-tumor peptide from the NC1 domain of collagen XIX Oncotarget (2015) 6, 3656-3668. PubMed Europe PubMed DOI
Singh,B., Al-Jubair,T., Voraganti,C., Andersson,T., Mukherjee,O., Su,Y.C., Zipfel,P. and Riesbeck,K. Moraxella catarrhalis binds plasminogen to evade host innate immunity Infect Immun (2015) 83, 3458-3469. PubMed Europe PubMed DOI

2014

Al-Horani,R.A. and Desai,U.R. Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders Med Res Rev (2014) 34, 1168-1216. PubMed Europe PubMed DOI V I
Bikker,F.J., Koop,G., Leusink,N.B., Nazmi,K., Kaman,W.E., Brand,H.S. and Veerman,E.C. Tailor made plasmin substrates as potential diagnostic tool to test for mastitis Vet Res Commun (2014) 38, 271-277. PubMed Europe PubMed DOI A P
Cheng,L., Pettersen,D., Ohlsson,B., Schell,P., Karle,M., Evertsson,E., Pahlen,S., Jonforsen,M., Plowright,A.T., Bostrom,J., Fex,T., Thelin,A., Hilgendorf,C., Xue,Y., Wahlund,G., Lindberg,W., Larsson,L.O. and Gustafsson,D. Discovery of the fibrinolysis inhibitor AZD6564, acting via interference of a protein-protein interaction ACS Med Chem Lett (2014) 5, 538-543. PubMed Europe PubMed DOI PMC EPMC S I
Gohda,K., Fujimori,K., Teno,N., Wanaka,K. and Tsuda,Y. Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cells Chem Biol Drug Des (2014) 83, 52-57. PubMed Europe PubMed DOI A
Hultman,K., Cortes-Canteli,M., Bounoutas,A., Richards,A.T., Strickland,S. and Norris,E.H. Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain J Thromb Haemost (2014) 12, 701-712. PubMed Europe PubMed DOI K
Koyanagi,K., Narasaki,R., Yamamichi,S., Suzuki,E. and Hasumi,K. Mechanism of the action of SMTP-7, a novel small-molecule modulator of plasminogen activation Blood Coagul Fibrinolysis (2014) 25, 316-321. PubMed Europe PubMed DOI
Kumar,Y., Vadivel,K., Schmidt,A.E., Ogueli,G.I., Ponnuraj,S.M., Rannulu,N., Loo,J.A., Bajaj,M.S. and Bajaj,S.P. Decoy plasminogen receptor containing a selective Kunitz-inhibitory domain Biochemistry (2014) 53, 505-517. PubMed Europe PubMed DOI
Sonderegger,P. and Matsumoto-Miyai,K. Activity-controlled proteolytic cleavage at the synapse Trends Neurosci (2014) 37, 413-423. PubMed Europe PubMed DOI
Teno,N., Gohda,K., Wanaka,K., Tsuda,Y., Sueda,T., Yamashita,Y. and Otsubo,T. Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin Bioorg Med Chem (2014) 22, 2339-2352. PubMed Europe PubMed DOI I
Valapala,M., Maji,S., Borejdo,J. and Vishwanatha,J.K. Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis J Biol Chem (2014) 289, 15915-15926. PubMed Europe PubMed DOI
Verhamme,I.M. and Bock,P.E. Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism J Biol Chem (2014) 289, 28006-28018. PubMed Europe PubMed DOI

2013

Aguda,R., Caronna,A., Hunt,J., Koepf,E., Lindsay,M., Miller,C., Rebbeor,J., Silverstein,R., Stokes,K. and Zimmerman,T. Production and purification of TAL6003: a novel version of the protease plasmin Protein Expr Purif (2013) 88, 41-46. PubMed Europe PubMed DOI U
Aneja,R., Datt,M., Yadav,S. and Sahni,G. Multiple exosites distributed across the three domains of streptokinase co-operate to generate high catalytic rates in the streptokinase-plasmin activator complex Biochemistry (2013) 52, 8957-8968. PubMed Europe PubMed DOI
Hoffmann,D.C., Willenborg,S., Koch,M., Zwolanek,D., Muller,S., Becker,A.K., Metzger,S., Ehrbar,M., Kurschat,P., Hellmich,M., Hubbell,J.A. and Eming,S.A. Proteolytic processing regulates placental growth factor activities J Biol Chem (2013) 288, 17976-17989. PubMed Europe PubMed DOI P
Law,R.H., Abu-Ssaydeh,D. and Whisstock,J.C. New insights into the structure and function of the plasminogen/plasmin system Curr Opin Struct Biol (2013) 23, 836-841. PubMed Europe PubMed DOI
Millers,E.K., Johnson,L.A., Birrell,G.W., Masci,P.P., Lavin,M.F., de Jersey,J. and Guddat,L.W. The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake PLoS ONE (2013) 8, e54104-e54104. PubMed Europe PubMed DOI PMC EPMC S
Saupe,S.M., Leubner,S., Betz,M., Klebe,G. and Steinmetzer,T. Development of new cyclic plasmin inhibitors with excellent potency and selectivity J Med Chem (2013) 56, 820-831. PubMed Europe PubMed DOI I
Tse,L.V., Marcano,V.C., Huang,W., Pocwierz,M.S. and Whittaker,G.R. Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase J Virol (2013) 87, 5161-5169. PubMed Europe PubMed DOI

2012

Barthel,D., Schindler,S. and Zipfel,P.F. Plasminogen is a complement inhibitor J Biol Chem (2012) 287, 18831-18842. PubMed Europe PubMed DOI
Canas,O., Parra,A.Q. and Ramirez,L.F.A. Porcine plasmin: determination of kinetic parameters and comparison with human plasmin Iatreia (2012) 25, 111-119.
Castellino,F.J. Plasmin [ISSN:978-0-12-407742-3] (2012) 3, 2958-2968. DOI
Deryugina,E.I. and Quigley,J.P. Cell surface remodeling by plasmin: a new function for an old enzyme J Biomed Biotechnol (2012) 2012, 564259-564259. PubMed Europe PubMed DOI PMC EPMC
Gohda,K., Teno,N., Wanaka,K. and Tsuda,Y. Predicting subsite interactions of plasmin with substrates and inhibitors through computational docking analysis J Enzyme Inhib Med Chem (2012) 27, 571-577. PubMed Europe PubMed DOI P I
Haerteis,S., Krappitz,M., Diakov,A., Krappitz,A., Rauh,R. and Korbmacher,C. Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the gamma subunit of the human epithelial sodium channel J Gen Physiol (2012) 140, 375-389. PubMed Europe PubMed DOI P
Kawao,N., Nagai,N., Tamura,Y., Horiuchi,Y., Okumoto,K., Okada,K., Suzuki,Y., Umemura,K., Yano,M., Ueshima,S., Kaji,H. and Matsuo,O. Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo Thromb Haemost (2012) 107, 749-759. PubMed Europe PubMed DOI K
Koch,T.K., Reuter,M., Barthel,D., Bohm,S., van den Elsen,J., Kraiczy,P., Zipfel,P.F. and Skerka,C. Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b PLoS ONE (2012) 7, e47638-e47638. PubMed Europe PubMed DOI PMC EPMC
Law,R.H., Caradoc-Davies,T., Cowieson,N., Horvath,A.J., Quek,A.J., Encarnacao,J.A., Steer,D., Cowan,A., Zhang,Q., Lu,B.G., Pike,R.N., Smith,A.I., Coughlin,P.B. and Whisstock,J.C. The X-ray crystal structure of full-length human plasminogen Cell Rep (2012) 1, 185-190. PubMed Europe PubMed DOI S
Saupe,S.M. and Steinmetzer,T. A new strategy for the development of highly potent and selective plasmin inhibitors J Med Chem (2012) 55, 1171-1180. PubMed Europe PubMed DOI I
Singh,S., Ashish and Dikshit,K.L. Pro42 and Val45 of staphylokinase modulate intermolecular interactions of His43-Tyr44 pair and specificity of staphylokinase-plasmin activator complex FEBS Lett (2012) 586, 653-658. PubMed Europe PubMed DOI
Svenningsen,P., Skott,O. and Jensen,B.L. Proteinuric diseases with sodium retention: is plasmin the link? Clin Exp Pharmacol Physiol (2012) 39, 117-124. PubMed Europe PubMed DOI
Swedberg,J.E. and Harris,J.M. Natural and engineered plasmin inhibitors: applications and design strategies Chembiochem (2012) 13, 336-348. PubMed Europe PubMed DOI V I
Syrovets,T., Lunov,O. and Simmet,T. Plasmin as a proinflammatory cell activator J Leukoc Biol (2012) 92, 509-519. PubMed Europe PubMed DOI V
Teno,N., Otsubo,T., Gohda,K., Wanaka,K., Sueda,T., Ikeda,K., Hijikata-Okunomiya,A. and Tsuda,Y. Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead J Pept Sci (2012) 18, 620-625. PubMed Europe PubMed DOI I
Xue,Y., Bodin,C. and Olsson,K. Crystal structure of the native plasminogen reveals an activation-resistant compact conformation J Thromb Haemost (2012) 10, 1385-1396. PubMed Europe PubMed DOI S

2011

Brauer,R., Beck,I.M., Roderfeld,M., Roeb,E. and Sedlacek,R. Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen BMC Biochem (2011) 12, 38-38. PubMed Europe PubMed DOI
Canas,B.O., Quijano,P.A. and Arbelaez,R.F. Activation and comparative kinetics of Ovis aries plasmin with human plasmin Rev MVZ Cordoba (2011) 16, 2364-2371.
Dahiya,M., Singh,S., Rajamohan,G., Sethi,D., Ashish and Dikshit,K.L. Intermolecular interactions in staphylokinase-plasmin(ogen) bimolecular complex: function of His43 and Tyr44 FEBS Lett (2011) 585, 1814-1820. PubMed Europe PubMed DOI
Laha,M., Panizzi,P., Nahrendorf,M. and Bock,P.E. Engineering streptokinase for generation of active site-labeled plasminogen analogs Anal Biochem (2011) 415, 105-115. PubMed Europe PubMed DOI
Marder,V.J. Historical perspective and future direction of thrombolysis research: the re-discovery of plasmin J Thromb Haemost (2011) 9 Suppl 1, 364-373. PubMed Europe PubMed DOI U
Moroy,G., Bourguet,E., Decarme,M., Sapi,J., Alix,A.J., Hornebeck,W. and Lorimier,S. Inhibition of human leukocyte elastase, plasmin and matrix metalloproteinases by oleic acid and oleoyl-galardin derivative(s) Biochem Pharmacol (2011) 81, 626-635. PubMed Europe PubMed DOI I
Schaller,J. and Gerber,S.S. The plasmin-antiplasmin system: structural and functional aspects Cell Mol Life Sci (2011) 68, 785-801. PubMed Europe PubMed DOI V
Swedberg,J.E. and Harris,J.M. Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors Biochemistry (2011) 50, 8454-8462. PubMed Europe PubMed DOI I
Teno,N., Gohda,K., Wanaka,K., Sueda,T. and Tsuda,Y. Identification of novel plasmin inhibitors possessing nitrile moiety as warhead Bioorg Med Chem Lett (2011) 21, 6305-6309. PubMed Europe PubMed DOI I
Venkatraman,L., Li,H., Dewey,C.F., Jr., White,J.K., Bhowmick,S.S., Yu,H. and Tucker-Kellogg,L. Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro Biophys J (2011) 101, 1825-1834. PubMed Europe PubMed DOI PMC EPMC
Wu,W.C., Chen,C.C., Liu,C.H., Wang,N.K., Chen,K.J., Chen,T.L., Hwang,Y.S., Li,L.M. and Lai,C.C. Plasmin treatment accelerates vascular endothelial growth factor clearance from rabbit eyes Invest Ophthalmol Vis Sci (2011) 52, 6162-6167. PubMed Europe PubMed DOI U
Yamamoto,H., Ben,S., Saitoh,S., Kamata,K., Iguchi,K. and Hoshino,M. Plasmin: its role in the extracellular processing of progalanin in tumor tissue Protein Pept Lett (2011) 18, 1204-1211. PubMed Europe PubMed DOI

2010

Dejouvencel,T., Doeuvre,L., Lacroix,R., Plawinski,L., Dignat-George,F., Lijnen,H.R. and Angles-Cano,E. Fibrinolytic cross-talk: a new mechanism for plasmin formation Blood (2010) 115, 2048-2056. PubMed Europe PubMed DOI
Hoover-Plow,J. Does plasmin have anticoagulant activity? Vasc Health Risk Manag (2010) 6, 199-205. PubMed Europe PubMed PMC EPMC
Ismail,B. and Nielsen,S.S. Invited review: Plasmin protease in milk: current knowledge and relevance to dairy industry J Dairy Sci (2010) 93, 4999-5009. PubMed Europe PubMed DOI
Iwaki,T., Malinverno,C., Smith,D., Xu,Z., Liang,Z., Ploplis,V.A. and Castellino,F.J. The generation and characterization of mice expressing a plasmin-inactivating active site mutation J Thromb Haemost (2010) 8, 2341-2344. PubMed Europe PubMed DOI K
Marder,V.J., Jahan,R., Gruber,T., Goyal,A. and Arora,V. Thrombolysis with plasmin: implications for stroke treatment Stroke (2010) 41, S45-S49. PubMed Europe PubMed DOI U
Marder,V.J., Manyak,S., Gruber,T., Goyal,A., Moreno,G., Hunt,J., Bromirski,J., Scuderi,P., Petteway,S.R., Jr. and Novokhatny,V. Haemostatic safety of a unique recombinant plasmin molecule lacking kringles 2-5 Thromb Haemost (2010) 104, 780-787. PubMed Europe PubMed DOI U

2009

Aneja,R., Datt,M., Singh,B., Kumar,S. and Sahni,G. Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation J Biol Chem (2009) 284, 32642-32650. PubMed Europe PubMed DOI
Hofmann,S.C., Voith,U., Schonau,V., Sorokin,L., Bruckner-Tuderman,L. and Franzke,C.W. Plasmin plays a role in the in vitro generation of the linear IgA dermatosis antigen LADB97 J Invest Dermatol (2009) 129, 1730-1739. PubMed Europe PubMed DOI
Nogami,K., Nishiya,K., Saenko,E.L., Takeyama,M., Ogiwara,K., Yoshioka,A. and Shima,M. Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36 J Biol Chem (2009) 284, 6934-6945. PubMed Europe PubMed DOI PMC EPMC P
Ohtsuka,K., Maekawa,I., Waki,M. and Takenaka,S. Electrochemical assay of plasmin activity and its kinetic analysis Anal Biochem (2009) 385, 293-299. PubMed Europe PubMed DOI A
Purwin,M., Bruzgo,I., Markowska,A. and Midura-Nowaczek,K. Short peptides containing L-lysine and epsilon-aminocaproic acid as potential plasmin inhibitors Pharmazie (2009) 64, 765-767. PubMed Europe PubMed DOI I
Svenningsen,P., Uhrenholt,T.R., Palarasah,Y., Skjodt,K., Jensen,B.L. and Skott,O. Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations Am J Physiol Regul Integr Comp Physiol (2009) 297, R1733-R1741. PubMed Europe PubMed DOI
Yuan,H., Vance,K.M., Junge,C.E., Geballe,M.T., Snyder,J.P., Hepler,J.R., Yepes,M., Low,C.M. and Traynelis,S.F. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors J Biol Chem (2009) 284, 12862-12873. PubMed Europe PubMed DOI PMC EPMC P
Zhang,D., Jiang,S., Ma,J., Jiang,J., Pan,D. and Xu,X. Molecular cloning, characterization and expression analysis of a clip-domain serine protease from pearl oyster Pinctada fucata Fish Shellfish Immunol (2009) 26, 662-668. PubMed Europe PubMed DOI

2008

Gray,K. and Ellis,V. Activation of pro-BDNF by the pericellular serine protease plasmin FEBS Lett (2008) 582, 907-910. PubMed Europe PubMed DOI P
Hunt,J.A., Petteway,S.R., Jr., Scuderi,P. and Novokhatny,V. Simplified recombinant plasmin: production and functional comparison of a novel thrombolytic molecule with plasma-derived plasmin Thromb Haemost (2008) 100, 413-419. PubMed Europe PubMed DOI E
Lei,H., Velez,G., Hovland,P., Hirose,T. and Kazlauskas,A. Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy Invest Ophthalmol Vis Sci (2008) 49, 42-48. PubMed Europe PubMed DOI T
Marder,V.J. Pre-clinical studies of plasmin: superior benefit-to-risk ratio of plasmin compared to tissue plasminogen activator Thromb Res (2008) 122 Suppl 3, S9-S9. PubMed Europe PubMed DOI U
Passero,C.J., Mueller,G.M., Rondon-Berrios,H., Tofovic,S.P., Hughey,R.P. and Kleyman,T.R. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit J Biol Chem (2008) 283, 36586-36591. PubMed Europe PubMed DOI PMC EPMC
Tanka-Salamon,A., Tenekedjiev,K., Machovich,R. and Kolev,K. Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids. Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulation FEBS J (2008) 275, 1274-1282. PubMed Europe PubMed DOI PMC EPMC A I

2007

Devy,L., Rabbani,S.A., Stochl,M., Ruskowski,M., Mackie,I., Naa,L., Toews,M., van Gool,R., Chen,J., Ley,A., Ladner,R.C., Dransfield,D.T. and Henderikx,P. PEGylated DX-1000: pharmacokinetics and antineoplastic activity of a specific plasmin inhibitor Neoplasia (2007) 9, 927-937. PubMed Europe PubMed DOI PMC EPMC
Gladysheva,I.P., Sazonova,I.Y., Houng,A., Hedstrom,L. and Reed,G.L. Regulation of nonproteolytic active site formation in plasminogen Biochemistry (2007) 46, 8879-8887. PubMed Europe PubMed DOI
Grundy,J.E., Hancock,M.A., Meixner,S.C., MacKenzie,R.C., Koschinsky,M.L. and Pryzdial,E.L. Plasminogen binds to plasmin-modulated factor Xa by Ca (2+) - and C-terminal lysine-dependent and -independent interactions Thromb Haemost (2007) 97, 38-44. PubMed Europe PubMed DOI
Markowska,A., Midura-Nowaczek,K. and Bruzgo,I. Low molecular peptides as potential inhibitors of plasmin Acta Pol Pharm (2007) 64, 355-358. PubMed Europe PubMed I
Nogami,K., Shima,M., Matsumoto,T., Nishiya,K., Tanaka,I. and Yoshioka,A. Mechanisms of plasmin-catalyzed inactivation of factor VIII: a crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation J Biol Chem (2007) 282, 5287-5295. PubMed Europe PubMed DOI P
[YEAR:14-2-2007]Sheehan,J.J., Zhou,C., Gravanis,I., Rogove,A.D., Wu,Y.P., Bogenhagen,D.F. and Tsirka,S.E. Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice J Neurosci (14-2-2007) 27, 1738-1745. PubMed Europe PubMed DOI K
[YEAR:28-1-2007]Stillfried,G.E., Saunders,D.N. and Ranson,M. Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Breast Cancer Res (28-1-2007) 9, R14-R14. PubMed Europe PubMed DOI PMC EPMC

2006

Rizzo,S., Pellegrini,G., Benocci,F., Belting,C., Baicchi,U. and Vispi,M. Autologous plasmin for pharmacologic vitreolysis prepared 1 hour before surgery Retina (2006) 26, 792-796. PubMed Europe PubMed DOI U
[YEAR:11-9-2006]Xue,F. and Seto,C.T. Structure-activity studies of cyclic ketone inhibitors of the serine protease plasmin: design, synthesis, and biological activity Bioorg Med Chem (11-9-2006) 14, 8467-8487. PubMed Europe PubMed DOI I

2005

Castellino,F.J. and Ploplis,V.A. Structure and function of the plasminogen/plasmin system Thromb Haemost (2005) 93, 647-654. PubMed Europe PubMed DOI V
Comer,M.B., Cackett,K.S., Gladwell,S., Wood,L.M. and Dawson,K.M. Thrombolytic activity of BB-10153, a thrombin-activatable plasminogen J Thromb Haemost (2005) 3, 146-153. PubMed Europe PubMed DOI
Ho-Tin-Noe,B., Rojas,G., Vranckx,R., Lijnen,H.R. and Angles-Cano,E. Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis FEBS J (2005) 272, 3387-3400. PubMed Europe PubMed DOI
Kwon,M., Yoon,C.S., Jeong,W., Rhee,S.G. and Waisman,D.M. Annexin A2-S100A10 heterotetramer, a novel substrate of thioredoxin J Biol Chem (2005) 280, 23584-23592. PubMed Europe PubMed DOI
[YEAR:23-12-2005]Quagraine,M.O., Tan,F., Tamei,H., Erdos,E.G. and Skidgel,R.A. Plasmin alters the activity and quaternary structure of human plasma carboxypeptidase N Biochem J (23-12-2005) 388, 81-91. PubMed Europe PubMed DOI PMC EPMC
[YEAR:12-8-2005]Warejcka,D.J. and Twining,S.S. Specific conformational changes of plasminogen induced by chloride ions, 6-aminohexanoic acid and benzamidine, but not the overall openness of plasminogen regulate, production of biologically active angiostatins Biochem J (12-8-2005) 392, 703-712. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:14-10-2005]Xue,F. and Seto,C.T. A comparison of cyclohexanone and tetrahydro-4H-thiopyran-4-one 1,1-dioxide as pharmacophores for the design of peptide-based inhibitors of the serine protease plasmin J Org Chem (14-10-2005) 70, 8309-8321. PubMed Europe PubMed DOI I
[YEAR:3-11-2005]Xue,F. and Seto,C.T. Selective inhibitors of the serine protease plasmin: probing the S3 and S3' subsites using a combinatorial library J Med Chem (3-11-2005) 48, 6908-6917. PubMed Europe PubMed DOI I

2004

[YEAR:10-9-2004]Beaufort,N., Leduc,D., Rousselle,J.C., Namane,A., Chignard,M. and Pidard,D. Plasmin cleaves the juxtamembrane domain and releases truncated species of the urokinase receptor (CD87) from human bronchial epithelial cells FEBS Lett (10-9-2004) 574, 89-94. PubMed Europe PubMed DOI
[YEAR:27-9-2004]Boxrud,P.D., Verhamme,I.M. and Bock,P.E. Resolution of conformational activation in the kinetic mechanism of plasminogen activation by streptokinase J Biol Chem (27-9-2004) 279, 36633-36641. PubMed Europe PubMed DOI
Castellino,F.J. Plasmin [ISSN:0-12-079610-4] (2004) 2, 1692-1699. V
[YEAR:29-10-2004]Ehinger,S., Schubert,W.D., Bergmann,S., Hammerschmidt,S. and Heinz,D.W. Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites J Mol Biol (29-10-2004) 343, 997-1005. PubMed Europe PubMed DOI
Gandorfer,A., Rohleder,M., Sethi,C., Eckle,D., Welge-Lussen,U., Kampik,A., Luthert,P. and Charteris,D. Posterior vitreous detachment induced by microplasmin Invest Ophthalmol Vis Sci (2004) 45, 641-647. PubMed Europe PubMed DOI
Novokhatny,V.V., Jesmok,G.J., Landskroner,K.A., Marder,V.J. and Zimmerman,T.P. Locally delivered plasmin: why should it be superior to plasminogen activators for direct thrombolysis? Trends Pharmacol Sci (2004) 25, 72-75. PubMed Europe PubMed DOI U
Ohyama,S., Harada,T., Chikanishi,T., Miura,Y. and Hasumi,K. Nonlysine-analog plasminogen modulators promote autoproteolytic generation of plasmin(ogen) fragments with angiostatin-like activity Eur J Biochem (2004) 271, 809-820. PubMed Europe PubMed DOI
Samara,G.J., Schaffner,A.D., Eisenstat,J. and Nguyen,H.L. The effects of the plasminogen pathway on scar tissue formation Laryngoscope (2004) 114, 46-49. PubMed Europe PubMed DOI K
[YEAR:27-8-2004]Sun,H., Ringdahl,U., Homeister,J.W., Fay,W.P., Engleberg,N.C., Yang,A.Y., Rozek,L.S., Wang,X., Sjobring,U. and Ginsburg,D. Plasminogen is a critical host pathogenicity factor for group A streptococcal infection Science (27-8-2004) 305, 1283-1286. PubMed Europe PubMed DOI
Syrovets,T. and Simmet,T. Novel aspects and new roles for the serine protease plasmin Cell Mol Life Sci (2004) 61, 873-885. PubMed Europe PubMed DOI
[YEAR:1-8-2004]Terzyan,S., Wakeham,N., Zhai,P., Rodgers,K. and Zhang,X.C. Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain Proteins (1-8-2004) 56, 277-284. PubMed Europe PubMed DOI
[YEAR:24-9-2004]Ward,P.N., Field,T.R., Rosey,E.L., Abu-Median,A.B., Lincoln,R.A. and Leigh,J.A. Complex interactions between bovine plasminogen and streptococcal plasminogen activator PauA J Mol Biol (24-9-2004) 342, 1101-1114. PubMed Europe PubMed DOI

2003

[YEAR:15-4-2003]Behrendt,N., List,K., Andreasen,P.A. and Dano,K. The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation Biochem J (15-4-2003) 371, 277-287. PubMed Europe PubMed DOI PMC EPMC
Guinn,L. and Doctor,V.M. Mechanism of the stimulatory effect of 6-aminohexanoic acid on plasminogen activation by streptokinase or tissue plasminogen activator: the role of chloride Eur J Drug Metab Pharmacokinet (2003) 28, 315-320. PubMed Europe PubMed
[YEAR:31-10-2003]Heinemann,F.S., Korza,G. and Ozols,J. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes J Biol Chem (31-10-2003) 278, 42966-42975. PubMed Europe PubMed DOI
Miles,L.A., Castellino,F.J. and Gong,Y. Critical role for conversion of Glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces Trends Cardiovasc Med (2003) 13, 21-30. PubMed Europe PubMed DOI
Nowak,P. and Zgirski,A. Effects of metal ions on activity of plasmin Biol Trace Elem Res (2003) 93, 87-94. PubMed Europe PubMed DOI
Rakic,J.M., Maillard,C., Jost,M., Bajou,K., Masson,V., Devy,L., Lambert,V., Foidart,J.M. and Noel,A. Role of plasminogen activator-plasmin system in tumor angiogenesis Cell Mol Life Sci (2003) 60, 463-473. PubMed Europe PubMed DOI
van der Laan,W.H., Ronday,H.K., TeKoppele,J.M., Breedveld,F.C., Huizinga,T.W. and Verheijen,J.H. No therapeutic effect of plasmin antagonist tranexamic acid in rheumatoid arthritis. A double-blind placebo-controlled pilot study Clin Exp Rheumatol (2003) 21, 359-362. PubMed Europe PubMed I

2002

[YEAR:22-2-2002]Abato,P., Yuen,C.M., Cubanski,J.Y. and Seto,C.T. Inhibitors of plasmin that extend into both the S and S' binding sites: Cooperative interactions between S1 and S2 J Org Chem (22-2-2002) 67, 1184-1191. PubMed Europe PubMed DOI I
[YEAR:6-9-2002]Burysek,L., Syrovets,T. and Simmet,T. The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and Janus kinase (JAK)/STAT signaling pathways J Biol Chem (6-9-2002) 277, 33509-33517. PubMed Europe PubMed DOI
Lapchak,P.A., Araujo,D.M., Pakola,S., Song,D., Wei,J. and Zivin,J.A. Microplasmin: a novel thrombolytic that improves behavioral outcome after embolic strokes in rabbits Stroke (2002) 33, 2279-2284. PubMed Europe PubMed DOI
[YEAR:13-9-2002]Tarui,T., Majumdar,M., Miles,L.A., Ruf,W. and Takada,Y. Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin J Biol Chem (13-9-2002) 277, 33564-33570. PubMed Europe PubMed DOI

2001

[YEAR:13-7-2001]Boxrud,P.D., Verhamme,I.M., Fay,W.P. and Bock,P.E. Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation J Biol Chem (13-7-2001) 276, 26084-26089. PubMed Europe PubMed DOI
[YEAR:1-6-2001]Gong,Y., Kim,S.O., Felez,J., Grella,D.K., Castellino,F.J. and Miles,L.A. Conversion of Glu-plasminogen to Lys-plasminogen is necessary for optimal stimulation of plasminogen activation on the endothelial cell surface J Biol Chem (1-6-2001) 276, 19078-19083. PubMed Europe PubMed DOI
[YEAR:6-7-2001]Jiang,Q., Taupenot,L., Mahata,S.K., Mahata,M., O'Connor,D.T., Miles,L.A. and Parmer,R.J. Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release J Biol Chem (6-7-2001) 276, 25022-25029. PubMed Europe PubMed DOI
[YEAR:23-3-2001]Kassam,G., Kwon,M., Yoon,C.S., Graham,K.S., Young,M.K., Gluck,S. and Waisman,D.M. Purification and characterization of A61. An angiostatin-like plasminogen fragment produced by plasmin autodigestion in the absence of sulfhydryl donors J Biol Chem (23-3-2001) 276, 8924-8933. PubMed Europe PubMed DOI
[YEAR:27-3-2001]Kornblatt,J.A., Rajotte,I. and Heitz,F. Reaction of canine plasminogen with 6-aminohexanoate: A thermodynamic study combining fluorescence, circular dichroism, and isothermal titration calorimetry Biochemistry (27-3-2001) 40, 3639-3647. PubMed Europe PubMed DOI
Lee,A.Y.Y., Fredenburgh,J.C., Stewart,R.J., Rischke,J.A. and Weitz,J.I. Like fibrin, (DD)E, the major degradation product of crosslinked fibrin, protects plasmin from inhibition by alpha2-antiplasmin Thromb Haemost (2001) 85, 502-508. PubMed Europe PubMed
Marder,V.J., Landskroner,K., Novokhatny,V., Zimmerman,T.P., Kong,M., Kanouse,J.J. and Jesmok,G. Plasmin induces local thrombolysis without causing hemorrhage: A comparison with tissue plasminogen activator in the rabbit Thromb Haemost (2001) 86, 739-745. PubMed Europe PubMed
[YEAR:13-4-2001]Said,B., HaMai,D. and Matsumoto,D.C. Purification of follicular regulatory protein: Possible plasminogen identity Biochem Biophys Res Commun (13-4-2001) 282, 1045-1052. PubMed Europe PubMed DOI
Vakili,J., Standker,L., Detheux,M., Vassart,G., Forssmann,W.G. and Parmentier,M. Urokinase plasminogen activator and plasmin efficiently convert hemofiltrate CC chemokine 1 into its active [9-74] processed variant J Immunol (2001) 167, 3406-3413. PubMed Europe PubMed P

2000

Creemers,E., Cleutjens,J., Smits,J., Heymans,S., Moons,L., Collen,D., Daemen,M. and Carmeliet,P. Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction Am J Pathol (2000) 156, 1865-1873. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:5-7-2000]Harris,J.L., Backes,B.J., Leonetti,F., Mahrus,S., Ellman,J.A. and Craik,C.S. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries Proc Natl Acad Sci U S A (5-7-2000) 97, 7754-7759. PubMed Europe PubMed DOI PMC EPMC P
Okada,Y., Tsuda,Y., Tada,M., Wanaka,K., Okamoto,U., Hijikata-Okunomiya,A. and Okamoto,S. Development of potent and selective plasmin and plasma kallikrein inhibitors and studies on the structure-activity relationship Chem Pharm Bull (Tokyo) (2000) 48, 1964-1972. PubMed Europe PubMed I
Parmer,R.J., Mahata,M., Gong,Y., Mahata,S.K., Jiang,Q., O'Connor,D.T., Xi,X.P. and Miles,L.A. Processing of chromogranin A by plasmin provides a novel mechanism for regulating catecholamine secretion J Clin Invest (2000) 106, 907-915. PubMed Europe PubMed DOI PMC EPMC
Parry,M.A., Zhang,X.C. and Bode,I. Molecular mechanisms of plasminogen activation: bacterial cofactors provide clues Trends Biochem Sci (2000) 25, 53-59. PubMed Europe PubMed DOI
Ploplis,V.A. and Castellino,F.J. Nonfibrinolytic functions of plasminogen Methods (2000) 21, 103-110. PubMed Europe PubMed DOI
[YEAR:1-2-2000]Samis,J.A., Ramsey,G.D., Walker,J.B., Nesheim,M.E. and Giles,A.R. Proteolytic processing of human coagulation factor IX by plasmin Blood (1-2-2000) 95, 943-951. PubMed Europe PubMed
van der Laan,W.H., Pap,T., Ronday,H.K., Grimbergen,J.M., Huisman,L.G., TeKoppele,J.M., Breedveld,F.C., Gay,R.E., Gay,S., Huizinga,T.W., Verheijen,J.H. and Quax,P.H. Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor Arthritis Rheum (2000) 43, 1710-1718. PubMed Europe PubMed DOI
Wang,S., Reed,G.L. and Hedstrom,L. Zymogen activation in the streptokinase-plasminogen complex. Ile1 is required for the formation of a functional active site Eur J Biochem (2000) 267, 3994-4001. PubMed Europe PubMed DOI
Wang,X., Terzyan,S., Tang,J., Loy,J.A., Lin,X. and Zhang,X.C. Human plasminogen catalytic domain undergoes an unusual conformational change upon activation J Mol Biol (2000) 295, 903-914. PubMed Europe PubMed DOI S

1999

Nilsen,S.L. and Castellino,F.J. Expression of human plasminogen in Drosophila Schneider S2 cells Protein Expr Purif (1999) 16, 136-143. PubMed Europe PubMed DOI E
[YEAR:24-8-1999]Peisach,E., Wang,J., de los Santos,T., Reich,E. and Ringe,D. Crystal structure of the proenzyme domain of plasminogen Biochemistry (24-8-1999) 38, 11180-11188. PubMed Europe PubMed DOI S
Pryzdial,E.L., Lavigne,N., Dupuis,N. and Kessler,G.E. Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor J Biol Chem (1999) 274, 8500-8505. PubMed Europe PubMed DOI
[YEAR:19-11-1999]Santala,A., Saarinen,J., Kovanen,P. and Kuusela,P. Activation of interstitial collagenase, MMP-1, by Staphylococcus aureus cells having surface-bound plasmin: a novel role of plasminogen receptors of bacteria FEBS Lett (19-11-1999) 461, 153-156. PubMed Europe PubMed DOI

1998

[YEAR:15-7-1998]Farina,A.R., Tacconelli,A., Teti,A., Gulino,A. and Mackay,A.R. Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate Cancer Res (15-7-1998) 58, 2957-2960. PubMed Europe PubMed
[YEAR:5-5-1998]Jespers,L., Van Herzeele,N., Lijnen,H.R., Van Hoef,B., De Maeyer,M., Collen,D. and Lasters,I. Arginine 719 in human plasminogen mediates formation of the staphylokinase:plasmin activator complex Biochemistry (5-5-1998) 37, 6380-6386. PubMed Europe PubMed DOI
Lijnen,H.R., Silence,J., Lemmens,G., Frederix,L. and Collen,D. Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system Thromb Haemost (1998) 79, 1171-1176. PubMed Europe PubMed
Ohkura,N., Hagihara,Y., Yoshimura,T., Goto,Y. and Kato,H. Plasmin can reduce the function of human beta2 glycoprotein I by cleaving domain V into a nicked form Blood (1998) 91, 4173-4179. PubMed Europe PubMed P
Parry,M.A., Fernandez-Catalan,C., Bergner,A., Huber,R., Hopfner,K.P., Schlott,B., Guhrs,K.H. and Bode,W. The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action Nat Struct Biol (1998) 5, 917-923. PubMed Europe PubMed DOI S
[YEAR:3-4-1998]Takeda-Shitaka,M. and Umeyama,H. Elucidation of the cause for reduced activity of abnormal human plasmin containing an Ala55-Thr mutation: Importance of highly conserved Ala55 in serine proteases FEBS Lett (3-4-1998) 425, 448-452. PubMed Europe PubMed DOI
Wang,X., Lin,X., Loy,J.A., Tang,J. and Zhang,X.C. Crystal structure of the catalytic domain of human plasmin complexed with streptokinase Science (1998) 281, 1662-1665. PubMed Europe PubMed DOI S

1997

Butenas,S., DiLorenzo,M.E. and Mann,K.G. Ultrasensitive fluorogenic substrates for serine proteases Thromb Haemost (1997) 78, 1193-1201. PubMed Europe PubMed A
Okumura,Y., Sato,H., Seiki,M. and Kido,H. Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activator FEBS Lett (1997) 402, 181-184. PubMed Europe PubMed DOI
Pirie-Shepherd,S.R., Stevens,R.D., Andon,N.L., Enghild,J.J. and Pizzo,S.V. Evidence for a novel O-linked sialylated trisaccharide on Ser-248 of human plasminogen 2 J Biol Chem (1997) 272, 7408-7411. PubMed Europe PubMed DOI
Schlott,B., Guhrs,K.H., Hartmann,M., Rocker,A. and Collen,D. Staphylokinase requires NH2-terminal proteolysis for plasminogen activation J Biol Chem (1997) 272, 6067-6072. PubMed Europe PubMed DOI
Wang,H., Prorok,M., Bretthauer,R.K. and Castellino,F.J. Serine-578 is a major phosphorylation locus in human plasma plasminogen Biochemistry (1997) 36, 8100-8106. PubMed Europe PubMed DOI

1996

Lijnen,H.R., Van Hoef,B. and Collen,D. Characterization of the murine plasminogen/urokinase-type plasminogen-activator system Eur J Biochem (1996) 241, 840-848. PubMed Europe PubMed
Romer,J., Bugge,T.H., Pyke,C., Lund,L.R., Flick,M.J., Degen,J.L. and Dano,K. Impaired wound healing in mice with a disrupted plasminogen gene Nat Med (1996) 2, 287-292. PubMed Europe PubMed K
Ueshima,S., Okada,K. and Matsuo,O. Stabilization of plasmin by lysine derivatives Clin Chim Acta (1996) 245, 7-18. PubMed Europe PubMed DOI I
Wijkmans,J.C.H.M., Nagel,A. and Bloemhoff,W. A novel chromogenic plasmin substrate Isoval-Phe-Lys-pNA-hydrochloride: a mild approach to the synthesis of N-alpha-peptidyl-L-lysine p-nitroanilides Int J Pept Res Ther (1996) 3, 107-112. A

1995

Bugge,T.H., Flick,M.J., Daugherty,C.C. and Degen,J.L. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction Genes Dev (1995) 9, 794-807. PubMed Europe PubMed K
Matsuzaki,T., Umeyama,H. and Kikumoto,R. Mechanisms of the selective inhibition of thrombin, factor Xa, plasmin and trypsin Pharmacochem Libr (1995) 23, 83-95. DOI S I
[YEAR:1-11-1995]Ploplis,V.A., Carmeliet,P., Vazirzadeh,S., Van Vlaenderen,I., Moons,L., Plow,E.F. and Collen,D. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice Circulation (1-11-1995) 92, 2585-2593. PubMed Europe PubMed K
Plow,E.F., Herren,T., Redlitz,A., Miles,L.A. and Hoover-Plow,J.L. The cell biology of the plasminogen system FASEB J (1995) 9, 939-945. PubMed Europe PubMed
Redlitz,A., Tan,A.K., Eaton,D.L. and Plow,E.F. Plasma carboxypeptidases as regulators of the plasminogen system J Clin Invest (1995) 96, 2534-2538. PubMed Europe PubMed DOI PMC EPMC
Wang,J. and Reich,E. Structure and function of microplasminogen: II. Determinants of activation by urokinase and by the bacterial activator streptokinase Protein Sci (1995) 4, 1768-1779. PubMed Europe PubMed DOI PMC EPMC

1994

Donovan,F.M., Vaughan,P.J. and Cunningham,D.D. Regulation of protease nexin-1 target protease specificity by collagen type IV J Biol Chem (1994) 269, 17199-17205. PubMed Europe PubMed
Varadi,K., Philapitsch,A., Santa,T. and Schwarz,H.P. Activation and inactivation of human protein C by plasmin Thromb Haemost (1994) 71, 615-621. PubMed Europe PubMed

1993

[YEAR:15-7-1993]Azuma,H., Uno,Y., Shigekiyo,T. and Saito,S. Congenital plasminogen deficiency caused by a Ser572 to Pro mutation Blood (15-7-1993) 82, 475-480. PubMed Europe PubMed M
[YEAR:15-4-1993]Collen,D., Schlott,B., Engelborghs,Y., Van Hoef,B., Hartmann,M., Lijnen,H.R. and Behnke,D. On the mechanism of the activation of human plasminogen by recombinant staphylokinase J Biol Chem (15-4-1993) 268, 8284-8289. PubMed Europe PubMed I
Teno,N., Wanaka,K., Okada,Y., Taguchi,H., Okamoto,U., Hijikata-Okunomiya,A. and Okamoto,S. Development of active center-directed plasmin and plasma kallikrein inhibitors and studies on the structure-inhibitory activity relationship Chem Pharm Bull (Tokyo) (1993) 41, 1079-1090. PubMed Europe PubMed I

1992

Ichinose,A. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis Biochemistry (1992) 31, 3113-3118. PubMed Europe PubMed DOI
Ponting,C.P., Marshall,J.M. and Cederholm-Williams,S.A. Plasminogen: a structural review Blood Coagul Fibrinolysis (1992) 3, 605-614. PubMed Europe PubMed

1991

Chain,D., Kreizman,T., Shapira,H. and Shaltiel,S. Plasmin cleavage of vitronectin. Identification of the site and consequent attenuation in binding plasminogen activator inhibitor-1 FEBS Lett (1991) 285, 251-256. PubMed Europe PubMed DOI

1990

Degen,S.J., Bell,S.M., Schaefer,L.A. and Elliott,R.W. Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17 Genomics (1990) 8, 49-61. PubMed Europe PubMed DOI
[YEAR:15-4-1990]Petersen,T.E., Martzen,M.R., Ichinose,A. and Davie,E.W. Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system J Biol Chem (15-4-1990) 265, 6104-6111. PubMed Europe PubMed M

1989

Whitefleet-Smith,J., Rosen,E., McLinden,J., Ploplis,V.A., Fraser,M.J., Tomlinson,J.E., McLean,J.W. and Castellino,F.J. Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system Arch Biochem Biophys (1989) 271, 390-399. PubMed Europe PubMed E

1988

Castellino,F.J., Urano,T., de Serrano,V., Morris,J.P. and Chibber,B.A. Control of human plasminogen activation Haemostasis (1988) 18 Suppl 1, 15-23. PubMed Europe PubMed
[YEAR:15-9-1988]Hortin,G.L., Gibson,B.L. and Fok,K.F. Alpha 2-antiplasmin's carboxy-terminal lysine residue is a major site of interaction with plasmin Biochem Biophys Res Commun (15-9-1988) 155, 591-596. PubMed Europe PubMed
Saino,T., Someno,T., Ishii,S., Aoyagi,T. and Umezawa,H. Protease-inhibitory activities of leupeptin analogues J Antibiot (Tokyo) (1988) 41, 220-225. PubMed Europe PubMed I

1987

[YEAR:1-2-1987]Angliker,H., Wikstrom,P., Rauber,P. and Shaw,E. The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B Biochem J (1-2-1987) 241, 871-875. PubMed Europe PubMed PMC EPMC I
Schaller,J., Marti,T., Rosselet,S.J., Kampfer,U. and Rickli,E.E. Amino acid sequence of the heavy chain of porcine plasmin. Comparison of the carbohydrate attachment sites with the human and bovine species Fibrinolysis (1987) 1, 91-102.

1986

[YEAR:25-1-1986]Collen,D., Zamarron,C., Lijnen,H.R. and Hoylaerts,M. Activation of plasminogen by pro-urokinase. II. Kinetics J Biol Chem (25-1-1986) 261, 1259-1266. PubMed Europe PubMed
[YEAR:25-1-1986]Lijnen,H.R., Zamarron,C., Blaber,M., Winkler,M.E. and Collen,D. Activation of plasminogen by pro-urokinase. I. Mechanism J Biol Chem (25-1-1986) 261, 1253-1258. PubMed Europe PubMed

1984

Castellino,F.J. Biochemistry of human plasminogen Semin Thromb Hemost (1984) 10, 18-23. PubMed Europe PubMed DOI

1982

Friberger,P., Knos,M., Gustavsson,S., Aurell,L. and Claeson,G. 12. A new specific substrate for the determination of plasmin activity Scand J Clin Lab Invest (1982) 42, 121-127. DOI A
Ranby,M. Studies on the kinetics of plasminogen activation by tissue plasminogen activator Biochim Biophys Acta (1982) 704, 461-469. PubMed Europe PubMed
Teger-Nilsson,A.-C., Friberger,P. and Gyzander,E. Determination of a new rapid plasmin inhibitor in human blood by means of a plasmin specific tripeptide substrate Scand J Clin Lab Invest (1982) 42, 403-409. DOI A

1981

Castellino,F.J. and Powell,J.R. Human plasminogen Methods Enzymol (1981) 80, 365-378. PubMed Europe PubMed DOI V
Robbins,K.C., Summaria,L. and Wohl,R.C. Human plasmin Methods Enzymol (1981) 80, 379-387. PubMed Europe PubMed DOI V
[YEAR:1-9-1981]Suenson,E. and Thorsen,S. Secondary-site binding of Glu-plasmin, Lys-plasmin and miniplasmin to fibrin Biochem J (1-9-1981) 197, 619-628. PubMed Europe PubMed PMC EPMC
[YEAR:29-5-1981]Thorsen,S., Clemmensen,I., Sottrup-Jensen,L. and Magnusson,S. Adsorption to fibrin of native fragments of known primary structure from human plasminogen Biochim Biophys Acta (29-5-1981) 668, 377-387. PubMed Europe PubMed

1980

Jackson,C.M. and Nemerson,Y. Blood coagulation Annu Rev Biochem (1980) 49, 765-811. PubMed Europe PubMed DOI
Kato,H., Adachi,N., Ohno,Y., Iwanaga,S., Takada,K. and Sakakibara,S. New fluorogenic peptide substrates for plasmin J Biochem (1980) 88, 183-190. PubMed Europe PubMed A
[YEAR:10-11-1980]Lijnen,H.R., Hoylaerts,M. and Collen,D. Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. Role in the regulation of fibrinolysis and identification as histidine-rich glycoprotein J Biol Chem (10-11-1980) 255, 10214-10222. PubMed Europe PubMed

1979

Castellino,F.J. A unique enzyme-protein substrate modifier reaction: plasmin/streptokinase interaction Trends Biochem Sci (1979) 4, 1-5.
[YEAR:25-7-1979]Wiman,B., Lijnen,H.R. and Collen,D. On the specific interaction between the lysine-binding sites in plasmin and complementary sites in alpha2-antiplasmin and in fibrinogen Biochim Biophys Acta (25-7-1979) 579, 142-154. PubMed Europe PubMed

1978

Goldsmith,G.H., Jr., Saito,H. and Ratnoff,O.S. The activation of plasminogen by Hageman factor (Factor XII) and Hageman factor fragments J Clin Invest (1978) 62, 54-60. PubMed Europe PubMed DOI PMC EPMC
[YEAR:10-3-1978]Sugino,H., Kakinuma,A. and Iwanaga,S. Plasminostreptin, a protein proteinase inhibitor produced by Streptomyces antifibrinolyticus. III. Elucidation of the primary structure J Biol Chem (10-3-1978) 253, 1546-1555. PubMed Europe PubMed
[YEAR:1-6-1978]Wiman,B., Boman,L. and Collen,D. On the kinetics of the reaction between human antiplasmin and a low-molecular-weight form of plasmin Eur J Biochem (1-6-1978) 87, 143-146. PubMed Europe PubMed
[YEAR:15-3-1978]Wiman,B. and Collen,D. On the kinetics of the reaction between human antiplasmin and plasmin Eur J Biochem (15-3-1978) 84, 573-578. PubMed Europe PubMed

1976

Castellino,F.J. and Sodetz,J.M. Rabbit plasminogen and plasmin isozymes Methods Enzymol (1976) 45, 273-286. PubMed Europe PubMed DOI V
Robbins,K.C. and Summaria,L. Plasminogen and plasmin Methods Enzymol (1976) 45, 257-273. PubMed Europe PubMed DOI V

1975

Harpel,P.C. and Cooper,N.R. Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin J Clin Invest (1975) 55, 593-604. PubMed Europe PubMed DOI PMC EPMC
Robbins,K.C., Boreisha,I.G., Arzadon,L., Summaria,L. and Barlow,G.H. Physical and chemical properties of the NH2-terminal glutamic acid and lysine forms of human plasminogen and their derived plasmins with an NH2-terminal lysine heavy (A) chain. Comparative data J Biol Chem (1975) 250, 4044-4047. PubMed Europe PubMed
Wiman,B.W. and Wallen,P. Structural relationship between "glutamic acid" and "lysine" forms of human plasminogen and their interaction with the NH2- teminal activation peptide as studies by affinity chromatography Eur J Biochem (1975) 50, 489-494. PubMed Europe PubMed

1973

Coats,E.A. Comparative inhibition of thrombin, plasmin, trypsin, and complement by benzamidines using substituent constants and regression analysis J Med Chem (1973) 16, 1102-1106. PubMed Europe PubMed I

1972

Wallen,P. and Wiman,B. Characterization of human plasminogen. II. Separation and partial characterization of different molecular forms of human plasminogen Biochim Biophys Acta (1972) 257, 122-134. PubMed Europe PubMed

1970

Wallen,P. and Wiman,B. Characterization of human plasminogen. I. On the relationship between different molecular forms of plasminogen demonstrated in plasma and found in purified preparations Biochim Biophys Acta (1970) 221, 20-30. PubMed Europe PubMed

1969

Chase,T., Jr. and Shaw,E. Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes Biochemistry (1969) 8, 2212-2224. PubMed Europe PubMed DOI I
[YEAR:29-4-1969]Colman,R.W. Activation of plasminogen by human plasma kallikrein Biochem Biophys Res Commun (29-4-1969) 35, 273-279. PubMed Europe PubMed
Ratnoff,O.D., Pensky,J., Ogston,D. and Naff,G.B. The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor J Exp Med (1969) 129, 315-331. PubMed Europe PubMed PMC EPMC

1967

Robbins,K.C., Summaria,L., Hsieh,B. and Shah,R.J. The peptide chains of human plasmin. Mechanism of activation of human plasminogen to plasmin J Biol Chem (1967) 242, 2333-2342. PubMed Europe PubMed
Summaria,L., Hsieh,B., Groskopf,W.R. and Robbins,K.C. The isolation and characterization of the S-carboxymethyl beta (light) chain derivative of human plasmin. The localization of the active site on the beta (light) chain J Biol Chem (1967) 242, 5046-5052. PubMed Europe PubMed

1965

Hummel,B.C.W., Schor,J.M., Buck,F.F., Boggiano,E. and DeRenzo,E.C. Quantitative enzymic assay of human plasminogen and plasmin with azocasein as substrate Anal Biochem (1965) 11, 532-547. A

1958

[YEAR:1-11-1958]Norman,P.S. and Hill,B.M. Studies of the plasmin system. III. Physical properties of the two plasmin inhibitors in plasma J Exp Med (1-11-1958) 108, 639-649. PubMed Europe PubMed PMC EPMC
[YEAR:1-7-1958]Norman,P.S. Studies of the plasmin system. II. Inhibition of plasmin by serum or plasma J Exp Med (1-7-1958) 108, 53-68. PubMed Europe PubMed PMC EPMC

1955

Grossi,C.E. and Cliffton,E.E. The lysis of arterial thrombi in rabbits and dogs by use of activated human plasminogen (fibrinolysin) (plasmin) Surgery (1955) 37, 794-802. PubMed Europe PubMed U

1952

Astrup,T. and Mullertz,S. The fibrin plate method for estimating fibrinolytic activity Arch Biochem Biophys (1952) 40, 346-351. PubMed Europe PubMed A
Kocholaty,W., Ellis,W.W. and Jensen,H. Activation of plasminogen by trypsin and plasmin Blood (1952) 7, 882-890. PubMed Europe PubMed

1947

Astrup,T. and Permin,P.M. Fibrinolysis in the animal organism Nature (1947) 159, 681-682. PubMed Europe PubMed

1945

Christensen,L.R. and Macleod,C.M. A proteolytic enzyme of serum: characterization, activation, and reaction with inhibitors J Gen Physiol (1945) 28, 559-583. PubMed Europe PubMed PMC EPMC