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Literature for peptidase S01.149: mast cell peptidase 4 (mouse numbering)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Berglund,P., Akula,S., Fu,Z., Thorpe,M. and Hellman,L.
    Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  2. Cespedes,N., Donnelly,E., Garrison,S., Haapanen,L., Van De Water,J. and Luckhart,S.
    Non-lethal Plasmodium yoelii infection drives complex patterns of Th2-type host immunity and mast cell-dependent bacteremia
    Infect Immun PubMed  Europe PubMed DOI
  3. Magnusdottir,E.I., Grujic,M., Bergman,J., Pejler,G. and Lagerstrom,M.C.
    Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
    J Neuroinflammation17, 123-123. PubMed  Europe PubMed DOI
    4. 2019
  4. Vangansewinkel,T., Lemmens,S., Geurts,N., Quanten,K., Dooley,D., Pejler,G. and Hendrix,S.
    Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury
    Sci Rep9, 3715-3715. PubMed  Europe PubMed DOI  K
    5. 2018
  5. Houde,M., Schwertani,A., Touil,H., Desbiens,L., Sarrhini,O., Lecomte,R., Lepage,M., Gagnon,H., Takai,S., Pejler,G., Jacques,D., Gobeil F Jr, Day,R. and D'Orleans-Juste,P.
    Mouse mast cell protease 4 deletion protects heart function and survival after permanent myocardial infarction
    Front Pharmacol9, 868-868. PubMed  Europe PubMed DOI  K
    6. 2017
  6. Shubin,N.J., Glukhova,V.A., Clauson,M., Truong,P., Abrink,M., Pejler,G., White,N.J., Deutsch,G.H., Reeves,S.R., Vaisar,T., James,R.G. and Piliponsky,A.M.
    Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation
    J Allergy Clin Immunol139, 323-334. PubMed  Europe PubMed DOI
    7. 2016
  7. Desbiens,L., Lapointe,C., Gharagozloo,M., Mahmoud,S., Pejler,G., Gris,D. and D'Orleans-Juste,P.
    Significant contribution of mouse mast cell protease 4 in early phases of experimental autoimmune encephalomyelitis
    Mediators Inflamm2016, 9797021-9797021. PubMed  Europe PubMed DOI
  8. Houde,M., Desbiens,L., Schwertani,A., Pejler,G., Iglarz,M. and D'Orleans-Juste,P.
    Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice
    Life Sci159, 71-75. PubMed  Europe PubMed DOI  K
  9. Lind,T., Gustafson,A.M., Calounova,G., Hu,L., Rasmusson,A., Jonsson,K.B., Wernersson,S., Abrink,M., Andersson,G., Larsson,S., Melhus,H. and Pejler,G.
    Increased bone mass in female mice lacking mast cell chymase
    PLoS ONE11, e0167964-e0167964. PubMed  Europe PubMed DOI  K
  10. Tejada,T., Tan,L., Torres,R.A., Calvert,J.W., Lambert,J.P., Zaidi,M., Husain,M., Berce,M.D., Naib,H., Pejler,G., Abrink,M., Graham,R.M., Lefer,D.J., Naqvi,N. and Husain,A.
    IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction
    Proc Natl Acad Sci U S A113, 6949-6954. PubMed  Europe PubMed DOI
    11. 2015
  11. Semaan,W., Desbiens,L., Houde,M., Labonte,J., Gagnon,H., Yamamoto,D., Takai,S., Laidlaw,T., Bkaily,G., Schwertani,A., Pejler,G., Levesque,C., Desjardins,R., Day,R. and D'Orleans-Juste,P.
    Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase
    Biochem Pharmacol94, 91-100. PubMed  Europe PubMed DOI  I
    12. 2014
  12. Bankova,L.G., Lezcano,C., Pejler,G., Stevens,R.L., Murphy,G.F., Austen,K.F. and Gurish,M.F.
    Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions
    J Immunol192, 2812-2820. PubMed  Europe PubMed DOI
  13. Nelissen,S., Vangansewinkel,T., Geurts,N., Geboes,L., Lemmens,E., Vidal,P.M., Lemmens,S., Willems,L., Boato,F., Dooley,D., Pehl,D., Pejler,G., Maurer,M., Metz,M. and Hendrix,S.
    Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4
    Neurobiol Dis62, 260-272. PubMed  Europe PubMed DOI
    14. 2013
  14. Beghdadi,W., Madjene,L.C., Claver,J., Pejler,G., Beaudoin,L., Lehuen,A., Daugas,E. and Blank,U.
    Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction
    Kidney Int84, 317-326. PubMed  Europe PubMed DOI  K
  15. Hendrix,S., Kramer,P., Pehl,D., Warnke,K., Boato,F., Nelissen,S., Lemmens,E., Pejler,G., Metz,M., Siebenhaar,F. and Maurer,M.
    Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4
    FASEB J27, 920-929. PubMed  Europe PubMed DOI  K
  16. Waern,I., Lundequist,A., Pejler,G. and Wernersson,S.
    Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation
    Mucosal Immunol6, 911-920. PubMed  Europe PubMed DOI  K
    17. 2012
  17. Caughey,G.H.
    Chymases
    [ISSN:978-0-12-407742-3]3, 2675-2683. DOI
  18. Piliponsky,A.M., Chen,C.C., Rios,E.J., Treuting,P.M., Lahiri,A., Abrink,M., Pejler,G., Tsai,M. and Galli,S.J.
    The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis
    Am J Pathol181, 875-886. PubMed  Europe PubMed DOI
    19. 2011
  19. Lin,L., Bankaitis,E., Heimbach,L., Li,N., Abrink,M., Pejler,G., An,L., Diaz,L.A., Werb,Z. and Liu,Z.
    Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid
    J Biol Chem286, 37358-37367. PubMed  Europe PubMed DOI  K
    20. 2010
  20. Kervinen,J., Crysler,C., Bayoumy,S., Abad,M.C., Spurlino,J., Deckman,I., Greco,M.N., Maryanoff,B.E. and de Garavilla,L.
    Potency variation of small-molecule chymase inhibitors across species
    Biochem Pharmacol80, 1033-1041. PubMed  Europe PubMed DOI  I
  21. Trivedi,N.N. and Caughey,G.H.
    Mast cell peptidases: chameleons of innate immunity and host defense
    Am J Respir Cell Mol Biol42, 257-267. PubMed  Europe PubMed DOI
  22. Younan,G., Suber,F., Xing,W., Shi,T., Kunori,Y., Abrink,M., Pejler,G., Schlenner,S.M., Rodewald,H.R., Moore,F.D., Jr., Stevens,R.L., Adachi,R., Austen,K.F. and Gurish,M.F.
    The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5
    J Immunol185, 7681-7690. PubMed  Europe PubMed DOI
    23. 2009
  23. Waern,I., Jonasson,S., Hjoberg,J., Bucht,A., Abrink,M., Pejler,G. and Wernersson,S.
    Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation
    J Immunol183, 6369-6376. PubMed  Europe PubMed DOI  K
    24. 2008
  24. Andersson,M.K., Karlson,U. and Hellman,L.
    The extended cleavage specificity of the rodent beta-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase
    Mol Immunol45, 766-775. PubMed  Europe PubMed DOI  P
    25. 2004
  25. Caughey,G.H.
    Chymases
    [ISSN:0-12-079610-4]2, 1531-1535.  V
  26. Li,M., Liu,K., Michalicek,J., Angus,J.A., Hunt,J.E., Dell'Italia,L.J., Feneley,M.P., Graham,R.M. and Husain,A.
    Involvement of chymase-mediated angiotensin II generation in blood pressure regulation
    J Clin Invest114, 112-120. PubMed  Europe PubMed DOI
  27. [YEAR:1-6-2004]Lundequist,A., Tchougounova,E., Abrink,M. and Pejler,G.
    Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II
    J Biol Chem279, 32339-32344. PubMed  Europe PubMed DOI
  28. Soga,Y., Takai,S., Koyama,T., Okamoto,Y., Ikeda,T., Nishimura,K., Miyazaki,M. and Komeda,M.
    Attenuation of adhesion formation after cardiac surgery with a chymase inhibitor in a hamster model
    J Thorac Cardiovasc Surg127, 72-78. PubMed  Europe PubMed DOI  I
    29. 2003
  29. [YEAR:4-8-2003]Tchougounova,E., Pejler,G. and Abrink,M.
    The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover
    J Exp Med198, 423-431. PubMed  Europe PubMed DOI
    30. 2002
  30. [YEAR:1-9-2002]Hori,S., Yamada,M., Ohtani,S., Hori,C., Yokomizo,T., Webb,T. and Shimokawa,T.
    Myonase is localized in skeletal muscle myofibrils
    J Biochem132, 417-425. PubMed  Europe PubMed
    31. 2001
  31. Kakizoe,E., Shiota,N., Tanabe,Y., Shimoura,K., Kobayashi,Y. and Okunishi,H.
    Isoform-selective upregulation of mast cell chymase in the development of skin fibrosis in scleroderma model mice
    J Invest Dermatol116, 118-123. PubMed  Europe PubMed DOI
    32. 2000
  32. [YEAR:14-7-2000]Caughey,G.H., Raymond,W.W. and Wolters,P.J.
    Angiotensin II generation by mast cell alpha- and beta-chymases
    Biochim Biophys Acta1480, 245-257. PubMed  Europe PubMed DOI
    33. 1999
  33. [YEAR:19-8-1999]Humphries,D.E., Wong,G.W., Friend,D.S., Gurish,M.F., Qiu,W.T., Huang,C., Sharpe,A.H. and Stevens,R.L.
    Heparin is essential for the storage of specific granule proteases in mast cells
    Nature400, 769-772. PubMed  Europe PubMed DOI
  34. [YEAR:15-3-1999]Jippo,T., Lee,Y.M., Katsu,Y., Tsujino,K., Morii,E., Kim,D.K., Kim,H.M. and Kitamura,Y.
    Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype
    Blood93, 1942-1950. PubMed  Europe PubMed
    35. 1998
  35. Holt,J.C., Hatcher,V.B., Caulfield,J.B., Norton,P., Umeda,P.K., Melendez,J.A., Martino,L., Mudzinsky,S.P., Blumenstock,F., Slayter,H.S. and Margossian,S.S.
    Cloning of the cDNA and nucleotide sequence of a skeletal muscle protease from myopathic hamsters
    Mol Cell Biochem181, 125-135. PubMed  Europe PubMed DOI
  36. Hori,S., Ohtani,S., Hori,C. and Nokihara,K.
    Purification and characterization of myonase from X-chromosome linked muscular dystrophic mouse skeletal muscle
    J Biochem123, 650-658. PubMed  Europe PubMed
  37. [YEAR:15-7-1998]Shiota,N., Fukamizu,A., Okunishi,H., Takai,S., Murakami,K. and Miyazaki,M.
    Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts
    Biochem J333, 417-424. PubMed  Europe PubMed
    38. 1997
  38. Lutzelschwab,C., Pejler,G., Aveskogh,M. and Hellman,L.
    Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations
    J Exp Med185, 13-29. PubMed  Europe PubMed DOI
    39. 1996
  39. Itoh,H., Murakumo,Y., Tomita,M., Ide,H., Kobayashi,T., Maruyama,H., Horii,Y. and Nawa,Y.
    Cloning of the cDNAs for mast-cell chymases from the jejunum of Mongolian gerbils, Meriones unguiculatus, and their sequence similarities with chymases expressed in the connective-tissue mast cells of mice and rats
    Biochem J314, 923-929. PubMed  Europe PubMed
    40. 1995
  40. Pejler,G. and Berg,L.
    Regulation of rat mast cell protease 1 activity. Protease inhibition is prevented by heparin proteoglycan
    Eur J Biochem233, 192-199. PubMed  Europe PubMed
  41. Pejler,G., Karlstrom,A.R. and Berg,L.
    Identification of the proteolytic thrombin fragments formed after cleavage with rat mast cell protease 1
    Eur J Biochem227, 102-107. PubMed  Europe PubMed DOI
  42. Springman,E.B. and Serafin,W.E.
    Structure, genetics, and regulation of expression of secretory endo- and exopeptidases of mouse mast cells
    Clin Allergy Immunol6, 169-201.
    43. 1994
  43. Huang,R. and Hellman,L.
    Genes for mast-cell serine protease and their molecular evolution
    Immunogenetics40, 397-414. PubMed  Europe PubMed
  44. Rouleau,A., Garbarg,M., Schwartz,J.C. and Ruat,M.
    Molecular cloning of rat mast cell protease 1 and development of specific probes for its gene transcript
    Biochem Biophys Res Commun199, 593-602. PubMed  Europe PubMed DOI
    45. 1993
  45. Gurish,M.F., Nadeau,J.H., Johnson,K.R., McNeil,H.P., Grattan,K.M., Austen,K.F. and Stevens,R.L.
    A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14
    J Biol Chem268, 11372-11379. PubMed  Europe PubMed
  46. [YEAR:25-4-1993]Sali,A., Matsumoto,R., McNeil,H.P., Karplus,M. and Stevens,R.L.
    Three-dimensional models of four mouse mast cell chymases. Identification of proteoglycan binding regions and protease-specific antigenic epitopes
    J Biol Chem268, 9023-9034. PubMed  Europe PubMed
    47. 1991
  47. Huang,R.Y., Blom,T. and Hellman,L.
    Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases
    Eur J Immunol21, 1611-1621. PubMed  Europe PubMed DOI
  48. [YEAR:25-1-1991]Serafin,W.E., Sullivan,T.P., Conder,G.A., Ebrahimi,A., Marcham,P., Johnson,S.S., Austen,K.F. and Reynolds,D.S.
    Cloning of the cDNA and gene for mouse mast cell protease 4. Demonstration of its late transcription in mast cell subclasses and analysis of its homology to subclass-specific neutral proteases of the mouse and rat
    J Biol Chem266, 1934-1941. PubMed  Europe PubMed
    49. 1990
  49. Reynolds,D.S., Stevens,R.L., Lane,W.S., Carr,M.H., Austen,K.F. and Serafin,W.E.
    Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases
    Proc Natl Acad Sci U S A87, 3230-3234. PubMed  Europe PubMed
    50. 1987
  50. Le Trong,H., Neurath,H. and Woodbury,R.G.
    Substrate specificity of the chymotrypsin-like protease in secretory granules isolated from rat mast cells
    Proc Natl Acad Sci U S A84, 364-367. PubMed  Europe PubMed
  51. Le Trong,H., Parmelee,D.C., Walsh,K.A., Neurath,H. and Woodbury,R.G.
    Amino acid sequence of rat mast cell protease I (chymase)
    Biochemistry26, 6988-6994. PubMed  Europe PubMed
  52. Woodbury,R.G., Trong,H.L. and Neurath,H.
    Structure and function of mast cell proteases
    Acta Histochem Cytochem20, 261-269.
    53. 1984
  53. Harper,J.W., Cook,R.R., Roberts,C.J., McLaughlin,B.J. and Powers,J.C.
    Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aalpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates
    Biochemistry23, 2995-3002. PubMed  Europe PubMed
    54. 1981
  54. Woodbury,R.G., Everitt,M.T. and Neurath,H.
    Mast cell proteases
    Methods Enzymol80, 588-609. PubMed  Europe PubMed DOI  V
    55. 1980
  55. [YEAR:2-6-1980]Woodbury,R.G. and Neurath,H.
    Structure, specificity and localization of the serine proteases of connective tissue
    FEBS Lett114, 189-196. PubMed  Europe PubMed DOI
  56. Yoshida,N., Everitt,M.T., Neurath,H., Woodbury,R.G. and Powers,J.C.
    Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G
    Biochemistry19, 5799-5804. PubMed  Europe PubMed  I
    57. 1978
  57. Woodbury,R.G., Gruzenski,G.M. and Lagunoff,D.
    Immunofluorescent localization of a serine protease in rat small intestine
    Proc Natl Acad Sci U S A75, 2785-2789. PubMed  Europe PubMed
  58. Woodbury,R.G., Everitt,M., Sanada,Y., Katunuma,N., Lagunoff,D. and Neurath,H.
    A major serine protease in rat skeletal muscle: evidence for its mast cell origin
    Proc Natl Acad Sci U S A75, 5311-5313. PubMed  Europe PubMed
    59. 1971
  59. Vensel,W.H., Komender,J. and Barnard,E.A.
    Non-pancreatic proteases of the chymotrypsin family. II. Two proteases from a mouse mast cell tumor
    Biochim Biophys Acta250, 395-407. PubMed  Europe PubMed

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