$VAR1 = undef;

Summary for peptidase S01.149: mast cell peptidase 4 (mouse numbering)

Names
MEROPS Name	mast cell peptidase 4 (mouse numbering)
Other names	mekratin, mMCP-4, myonase, rat mast cell protease 1, rMCP-1, connective-tissue-type mast-cell-specific chymase (Mus musculus), chymase 4 (Mus musculus), chymase 1 (Rattus norvegicus), hamster chymase 1, Mcpt4 g.p. (Mus musculus)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.149
Holotype	mast cell peptidase 4 (mouse numbering) (Rattus norvegicus), Uniprot accession P09650 (peptidase unit: 21-246), MERNUM MER0000125
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Physiology	Kakizoe et al. (2001) contend that the connective-tissue-type mouse mast cell chymase mMCP-4 plays a crucial role in fibroproliferative remodeling of the skin, whereas mMCP-5 does not.
Other databases	TREEFAM	http://www.treefam.org/family/TF333630
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/yfw-/h/-/- (based on 11 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	2	0	2	0
Pro	0	0	3	0	0	0	3	1
Ala	0	0	0	0	0	1	0	0
Val	1	2	2	1	1	0	0	2
Leu	1	0	0	0	0	2	1	1
Ile	2	2	1	0	2	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	0	3	1	0	0	1
Tyr	0	0	1	5	0	0	0	0
Trp	0	0	1	2	0	0	0	0
Ser	0	1	0	0	0	0	1	1
Thr	0	0	2	0	1	2	1	0
Cys	1	1	0	0	1	1	0	0
Asn	0	0	0	0	1	1	0	0
Gln	0	0	0	0	0	0	0	0
Asp	2	0	1	0	0	0	0	1
Glu	2	1	0	0	0	0	0	2
Lys	0	1	0	0	0	0	0	0
Arg	1	2	0	0	0	0	0	0
His	0	1	0	0	1	3	1	0

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
Mcpt4	14:C1		ENSMUSG00000022226	17227	MGI:96940