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Literature for peptidase S01.136: granzyme B, rodent-type

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Ben-Eltriki,M., Ahmadi,A.R., Nakao,Y., Golla,K., Lakschevitz,F., Hakkinen,L., Granville,D.J. and Kim,H.
    Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation
    J Periodontal Res59, 94-103. PubMed  Europe PubMed DOI
  2. Fu,J., Xi,H., Cai,S., Peng,Y., Liu,Q., Qiu,L. and Lin,J.
    Development of Granzyme B-targeted Smart Positron Emission Tomography Probes for Monitoring Tumor Early Response to Immunotherapy
    ACS Nano18, 18910-18921. PubMed  Europe PubMed DOI
  3. Heidari,P., Haj-Mirzaian,A., Prabhu,S., Ataeinia,B., Esfahani,S.A. and Mahmood,U.
    Granzyme B PET Imaging for Assessment of Disease Activity in Inflammatory Bowel Disease
    J Nucl Med65, 1137-1143. PubMed  Europe PubMed DOI
    4. 2022
  4. Xu,L., Liu,N., Zhan,W., Deng,Y., Chen,Z., Liu,X., Gao,G., Chen,Q., Liu,Z. and Liang,G.
    Granzyme B Turns Nanoparticle Fluorescence "On" for Imaging Cytotoxic T Lymphocyte Activity in Vivo
    ACS Nano16, 19328-19334. PubMed  Europe PubMed DOI
    5. 2020
  5. Chitirala,P., Chang,H.F., Martzloff,P., Harenberg,C., Ravichandran,K., Abdulreda,M.H., Berggren,P.O., Krause,E., Schirra,C., Leinders-Zufall,T., Benseler,F., Brose,N. and Rettig,J.
    Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse
    elife9, PubMed  Europe PubMed DOI
  6. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Extended cleavage specificities of two mast cell chymase-related proteases and one granzyme B-like protease from the platypus, a monotreme
    Int J Mol Sci21, PubMed  Europe PubMed DOI
    7. 2018
  7. Shen,Y., Zeglinski,M.R., Turner,C.T., Raithatha,S.A., Wu,Z., Russo,V., Oram,C., Hiroyasu,S., Nabai,L., Zhao,H., Bozin,T., Westendorf,K., Kopko,I., Huang,R., Arns,S., Tan,J., Zeng,H., Boey,A., Liggins,R., Jaquith,J., Cameron,D.R., Papp,A. and Granville,D.J.
    Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing
    Exp Mol Med50, 68-68. PubMed  Europe PubMed DOI  I
    8. 2017
  8. Larimer,B.M., Wehrenberg-Klee,E., Dubois,F., Mehta,A., Kalomeris,T., Flaherty,K., Boland,G. and Mahmood,U.
    Granzyme B PET imaging as a predictive biomarker of immunotherapy response
    Cancer Res77, 2318-2327. PubMed  Europe PubMed DOI  L
    9. 2016
  9. Shen,Y., Cheng,F., Sharma,M., Merkulova,Y., Raithatha,S.A., Parkinson,L.G., Zhao,H., Westendorf,K., Bohunek,L., Bozin,T., Hsu,I., Ang,L.S., Williams,S.J., Bleackley,R.C., Eriksson,J.E., Seidman,M.A., McManus,B.M. and Granville,D.J.
    Granzyme B deficiency protects against angiotensin II-induced cardiac fibrosis
    Am J Pathol186, 87-100. PubMed  Europe PubMed DOI  K
    10. 2015
  10. Parkinson,L.G., Toro,A., Zhao,H., Brown,K., Tebbutt,S.J. and Granville,D.J.
    Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation
    Aging Cell14, 67-77. PubMed  Europe PubMed DOI
    11. 2014
  11. Andoniou,C.E., Sutton,V.R., Wikstrom,M.E., Fleming,P., Thia,K.Y., Matthews,A.Y., Kaiserman,D., Schuster,I.S., Coudert,J.D., Eldi,P., Chaudhri,G., Karupiah,G., Bird,P.I., Trapani,J.A. and Degli-Esposti,M.A.
    A natural genetic variant of granzyme B confers lethality to a common viral infection
    PLoS Pathog10, e1004526-e1004526. PubMed  Europe PubMed DOI  M
  12. Hagn,M., Sutton,V.R. and Trapani,J.A.
    A colorimetric assay that specifically measures granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
    J Vis Expe52419-e52419. PubMed  Europe PubMed DOI  A  P
  13. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.
    Holistic view on the extended substrate specificities of orthologous granzymes
    J Proteome Res13, 1785-1793. PubMed  Europe PubMed DOI  P
  14. Prakash,M.D., Munoz,M.A., Jain,R., Tong,P.L., Koskinen,A., Regner,M., Kleifeld,O., Ho,B., Olson,M., Turner,S.J., Mrass,P., Weninger,W. and Bird,P.I.
    Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling
    Immunity41, 960-972. PubMed  Europe PubMed DOI
  15. Van Damme,P., Plasman,K., Vandemoortele,G., Jonckheere,V., Maurer-Stroh,S. and Gevaert,K.
    Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B
    BMC Biochem15, 21-21. PubMed  Europe PubMed DOI  P
    16. 2012
  16. Froelich,C.J.
    Granzyme B
    [ISSN:978-0-12-407742-3]3, 2718-2721. DOI
  17. Hagn,M., Belz,G.T., Kallies,A., Sutton,V.R., Thia,K.Y., Tarlinton,D.M., Hawkins,E.D. and Trapani,J.A.
    Activated mouse B cells lack expression of granzyme B
    J Immunol188, 3886-3892. PubMed  Europe PubMed DOI
  18. Stewart,S.E., Mangan,M.S., Bird,P.I. and Kaiserman,D.
    Detection of human and mouse granzyme B activity in cell extracts
    Methods Mol Biol844, 251-260. PubMed  Europe PubMed DOI  A
    19. 2011
  19. Ang,L.S., Boivin,W.A., Williams,S.J., Zhao,H., Abraham,T., Carmine-Simmen,K., McManus,B.M., Bleackley,R.C. and Granville,D.J.
    Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm
    Cell Death Dis2, e209-e209. PubMed  Europe PubMed DOI
  20. Hiebert,P.R., Boivin,W.A., Abraham,T., Pazooki,S., Zhao,H. and Granville,D.J.
    Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice
    Exp Gerontol46, 489-499. PubMed  Europe PubMed DOI
    21. 2010
  21. Afonina,I.S., Cullen,S.P. and Martin,S.J.
    Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B
    Immunol Rev235, 105-116. PubMed  Europe PubMed DOI  V
  22. D'Angelo,M.E., Bird,P.I., Peters,C., Reinheckel,T., Trapani,J.A. and Sutton,V.R.
    Cathepsin H is an additional convertase of pro-granzyme B
    J Biol Chem285, 20514-20519. PubMed  Europe PubMed DOI
    23. 2009
  23. Boivin,W.A., Cooper,D.M., Hiebert,P.R. and Granville,D.J.
    Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma
    Lab Invest89, 1195-1220. PubMed  Europe PubMed DOI  V
  24. Van Damme,P., Maurer-Stroh,S., Plasman,K., Van Durme,J., Colaert,N., Timmerman,E., De Bock,P.J., Goethals,M., Rousseau,F., Schymkowitz,J., Vandekerckhove,J. and Gevaert,K.
    Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs
    Mol Cell Proteomics8, 258-272. PubMed  Europe PubMed DOI  P
    25. 2008
  25. Chowdhury,D. and Lieberman,J.
    Death by a thousand cuts: granzyme pathways of programmed cell death
    Annu Rev Immunol26, 389-420. PubMed  Europe PubMed DOI  V
    26. 2007
  26. Cao,X., Cai,S.F., Fehniger,T.A., Song,J., Collins,L.I., Piwnica-Worms,D.R. and Ley,T.J.
    Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
    Immunity27, 635-646. PubMed  Europe PubMed DOI  K
  27. Casciola-Rosen,L., Garcia-Calvo,M., Bull,H.G., Becker,J.W., Hines,T., Thornberry,N.A. and Rosen,A.
    Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the Bid pathway
    J Biol Chem282, 4545-4552. PubMed  Europe PubMed DOI  P
  28. [YEAR:12-2-2007]Cullen,S.P., Adrain,C., Luthi,A.U., Duriez,P.J. and Martin,S.J.
    Human and murine granzyme B exhibit divergent substrate preferences
    J Cell Biol176, 435-444. PubMed  Europe PubMed DOI  P
  29. Pardo,J., Wallich,R., Ebnet,K., Iden,S., Zentgraf,H., Martin,P., Ekiciler,A., Prins,A., Mullbacher,A., Huber,M. and Simon,M.M.
    Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin
    Cell Death Differ14, 1768-1779. PubMed  Europe PubMed DOI
  30. Thia,K.Y. and Trapani,J.A.
    The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains
    Tissue Antigens70, 198-204. PubMed  Europe PubMed DOI
    31. 2006
  31. [YEAR:16-1-2006]Adrain,C., Duriez,P.J., Brumatti,G., Delivani,P. and Martin,S.J.
    The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics
    J Biol Chem281, 8118-8125. PubMed  Europe PubMed DOI
    32. 2005
  32. [YEAR:24-3-2005]Blink,E.J., Jiansheng,Z., Hu,W., Calanni,S.T., Trapani,J.A., Bird,P.I. and Jans,D.A.
    Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9
    J Cell Biochem95, 598-610. PubMed  Europe PubMed DOI
  33. Choy,J.C., Cruz,R.P., Kerjner,A., Geisbrecht,J., Sawchuk,T., Fraser,S.A., Hudig,D., Bleackley,R.C., Jirik,F.R., McManus,B.M. and Granville,D.J.
    Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease
    Am J Transplant5, 494-499. PubMed  Europe PubMed DOI
  34. [YEAR:15-2-2005]Gondek,D.C., Lu,L.F., Quezada,S.A., Sakaguchi,S. and Noelle,R.J.
    Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
    J Immunol174, 1783-1786. PubMed  Europe PubMed
  35. Graham,K.L., Thibault,D.L., Steinman,J.B., Okeke,L., Kao,P.N. and Utz,P.J.
    Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus
    Arthritis Rheum52, 1684-1693. PubMed  Europe PubMed DOI
  36. [YEAR:4-11-2005]Kurschus,F.C., Bruno,R., Fellows,E., Falk,C.S. and Jenne,D.E.
    Membrane receptors are not required to deliver granzyme B during killer cell attack
    Blood105, 2049-2058. PubMed  Europe PubMed DOI
  37. [YEAR:15-2-2005]Revell,P.A., Grossman,W.J., Thomas,D.A., Cao,X., Behl,R., Ratner,J.A., Lu,Z.H. and Ley,T.J.
    Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions
    J Immunol174, 2124-2131. PubMed  Europe PubMed
  38. [YEAR:7-2-2005]Sebbagh,M., Hamelin,J., Bertoglio,J., Solary,E. and Breard,J.
    Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
    J Exp Med201, 465-471. PubMed  Europe PubMed DOI
  39. [YEAR:1-12-2005]Waterhouse,N.J., Sedelies,K.A., Browne,K.A., Wowk,M.E., Newbold,A., Sutton,V.R., Clarke,C.J., Oliaro,J., Lindemann,R.K., Bird,P.I., Johnstone,R.W. and Trapani,J.A.
    A central role for Bid in granzyme B-induced apoptosis
    J Biol Chem280, 4476-4482. PubMed  Europe PubMed DOI
    40. 2004
  40. Froelich,C.J.
    Granzyme B
    [ISSN:0-12-079610-4]2, 1549-1552.  V
  41. [YEAR:8-11-2004]Pardo,J., Bosque,A., Brehm,R., Wallich,R., Naval,J., Mullbacher,A., Anel,A. and Simon,M.M.
    Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
    J Cell Biol167, 457-468. PubMed  Europe PubMed DOI
  42. [YEAR:3-5-2004]Ruggles,S.W., Fletterick,R.J. and Craik,C.S.
    Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity
    J Biol Chem279, 30751-30759. PubMed  Europe PubMed DOI
  43. Wowk,M.E. and Trapani,J.A.
    Cytotoxic activity of the lymphocyte toxin granzyme B
    Microbes Infect6, 752-758. PubMed  Europe PubMed DOI
    44. 2003
  44. Andrade,F., Casciola-Rosen,L.A. and Rosen,A.
    A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite
    Mol Cell Biol23, 6315-6326. PubMed  Europe PubMed DOI
  45. [YEAR:1-5-2003]Ewen,C., Kane,K.P., Shostak,I., Griebel,P.J., Bertram,E.M., Watts,T.H., Bleackley,R.C. and McElhaney,J.E.
    A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for granzyme B
    J Immunol Methods276, 89-101. PubMed  Europe PubMed DOI  A
  46. Goping,I.S., Barry,M., Liston,P., Sawchuk,T., Constantinescu,G., Michalak,K.M., Shostak,I., Roberts,D.L., Hunter,A.M., Korneluk,R. and Bleackley,R.C.
    Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition
    Immunity18, 355-365. PubMed  Europe PubMed DOI
  47. Ida,H., Nakashima,T., Kedersha,N.L., Yamasaki,S., Huang,M., Izumi,Y., Miyashita,T., Origuchi,T., Kawakami,A., Migita,K., Bird,P.I., Anderson,P. and Eguchi,K.
    Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death
    Eur J Immunol33, 3284-3292. PubMed  Europe PubMed DOI
  48. [YEAR:4-3-2003]McIlroy,D., Cartron,P.F., Tuffery,P., Dudoit,Y., Samri,A., Autran,B., Vallette,F.M., Debre,P. and Theodorou,I.
    A triple-mutated allele of granzyme B incapable of inducing apoptosis
    Proc Natl Acad Sci U S A100, 2562-2567. PubMed  Europe PubMed DOI  M
  49. [YEAR:17-3-2003]Metkar,S.S., Wang,B., Ebbs,M.L., Kim,J.H., Lee,Y.J., Raja,S.M. and Froelich,C.J.
    Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis
    J Cell Biol160, 875-885. PubMed  Europe PubMed DOI
  50. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.
    Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
    Biochem Biophys Res Commun308, 726-735. PubMed  Europe PubMed DOI
  51. Sutton,V.R., Wowk,M.E., Cancilla,M. and Trapani,J.A.
    Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors
    Immunity18, 319-329. PubMed  Europe PubMed DOI
    52. 2001
  52. Davis,J.E., Smyth,M.J. and Trapani,J.A.
    Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity
    Eur J Immunol31, 39-47. PubMed  Europe PubMed DOI
  53. [YEAR:1-2-2001]Gahring,L.C., Carlson,N.G., Meyer,E.L. and Rogers,S.W.
    Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation
    J Immunol166, 1433-1438. PubMed  Europe PubMed
    54. 2000
  54. Barry,M., Heibein,J.A., Pinkoski,M.J., Lee,S.F., Moyer,R.W., Green,D.R. and Bleackley,R.C.
    Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving bid
    Mol Cell Biol20, 3781-3794. PubMed  Europe PubMed DOI
  55. [YEAR:5-7-2000]Harris,J.L., Backes,B.J., Leonetti,F., Mahrus,S., Ellman,J.A. and Craik,C.S.
    Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
    Proc Natl Acad Sci U S A97, 7754-7759. PubMed  Europe PubMed DOI  P
  56. [YEAR:7-3-2000]Kam,C.M., Hudig,D. and Powers,J.C.
    Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors
    Biochim Biophys Acta1477, 307-323. PubMed  Europe PubMed DOI  V
  57. Shi,L., Yang,X., Froelich,C.J. and Greenberg,A.H.
    Purification and use of granzyme B
    Methods Enzymol322, 125-143. PubMed  Europe PubMed  V
  58. Thomas,D.A., Du,C., Xu,M., Wang,X. and Ley,T.J.
    DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
    Immunity12, 621-632. PubMed  Europe PubMed
  59. Waugh,S.M., Harris,J.L., Fletterick,R. and Craik,C.S.
    The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity
    Nat Struct Biol7, 762-765. PubMed  Europe PubMed DOI  S
    60. 1999
  60. Blink,E.J., Trapani,J.A. and Jans,D.A.
    Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?
    Immunol Cell Biol77, 206-215. PubMed  Europe PubMed DOI
  61. [YEAR:1-6-1999]Caputo,A., Parrish,J.C., James,M.N., Powers,J.C. and Bleackley,R.C.
    Electrostatic reversal of serine proteinase substrate specificity
    Proteins35, 415-424. PubMed  Europe PubMed DOI
  62. [YEAR:23-11-1999]Mullbacher,A., Waring,P., Tha Hla,R., Tran,T., Chin,S., Stehle,T., Museteanu,C. and Simon,M.M.
    Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
    Proc Natl Acad Sci U S A96, 13950-13955. PubMed  Europe PubMed DOI
    63. 1998
  63. Andrade,F., Roy,S., Nicholson,D., Thornberry,N., Rosen,A. and Casciola-Rosen,L.
    Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis
    Immunity8, 451-460. PubMed  Europe PubMed DOI
  64. Bird,C.H., Sutton,V.R., Sun,J., Hirst,C.E., Novak,A., Kumar,S., Trapani,J.A. and Bird,P.I.
    Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
    Mol Cell Biol18, 6387-6398. PubMed  Europe PubMed
  65. [YEAR:16-10-1998]Harris,J.L., Peterson,E.P., Hudig,D., Thornberry,N.A. and Craik,C.S.
    Definition and redesign of the extended substrate specificity of granzyme B
    J Biol Chem273, 27364-27373. PubMed  Europe PubMed DOI
  66. [YEAR:16-1-1998]Pham,C.T., Thomas,D.A., Mercer,J.D. and Ley,T.J.
    Production of fully active recombinant murine granzyme B in yeast
    J Biol Chem273, 1629-1633. PubMed  Europe PubMed DOI  E  I
  67. [YEAR:13-2-1998]Xia,Z., Kam,C.M., Huang,C., Powers,J.C., Mandle,R.J., Stevens,R.L. and Lieberman,J.
    Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system
    Biochem Biophys Res Commun243, 384-389. PubMed  Europe PubMed DOI
  68. [YEAR:18-12-1998]Yang,X., Stennicke,H.R., Wang,B., Green,D.R., Janicke,R.U., Srinivasan,A., Seth,P., Salvesen,G.S. and Froelich,C.J.
    Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7
    J Biol Chem273, 34278-34283. PubMed  Europe PubMed DOI
    69. 1997
  69. Babichuk,C.K. and Bleackley,R.C.
    Mutational analysis of the murine granzyme B gene promoter in primary T cells and a T cell clone
    J Biol Chem272, 18564-18571. PubMed  Europe PubMed DOI
  70. Hommel-Berrey,G.A., Bochan,M.R., Montel,A.H., Goebel,W.S., Froelich,C.J. and Brahmi,Z.
    Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus
    Cell Immunol180, 1-9. PubMed  Europe PubMed DOI
  71. Talanian,R.V., Yang,X., Turbov,J., Seth,P., Ghayur,T., Casiano,C.A., Orth,K. and Froelich,C.J.
    Granule-mediated killing: pathways for granzyme B-initiated apoptosis
    J Exp Med186, 1323-1331. PubMed  Europe PubMed DOI
  72. Van de Craen,M., van den Brande,I., Declercq,W., Irmler,M., Beyaert,R., Tschopp,J., Fiers,W. and Vandenabeele,P.
    Cleavage of caspase family members by granzyme B: a comparative study in vitro
    Eur J Immunol27, 1296-1299. PubMed  Europe PubMed DOI
    73. 1996
  73. [YEAR:12-7-1996]Duan,H., Orth,K., Chinnaiyan,A.M., Poirier,G.G., Froelich,C.J., He,W.W. and Dixit,V.M.
    ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B
    J Biol Chem271, 16720-16724. PubMed  Europe PubMed DOI
  74. Gu,Y., Sarnecki,C., Fleming,M.A., Lippke,J.A., Bleackley,R.C. and Su,M.S.
    Processing and activation of CMH-1 by granzyme B
    J Biol Chem271, 10816-10820. PubMed  Europe PubMed DOI
  75. Martin,S.J., Amarante-Mendes,G.P., Shi,L., Chuang,T.H., Casiano,C.A., O'Brien,G.A., Fitzgerald,P., Tan,E.M., Bokoch,G.M., Greenberg,A.H. and Green,D.R.
    The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease,CPP32, via a novel two- step mechanism
    EMBO J15, 2407-2416. PubMed  Europe PubMed
  76. Quan,L.T., Tewari,M., O'Rourke,K., Dixit,V., Snipas,S.J., Poirier,G.G., Ray,C., Pickup,D.J. and Salvesen,G.S.
    Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B
    Proc Natl Acad Sci U S A93, 1972-1976. PubMed  Europe PubMed
  77. Smyth,M.J., O'Connor,M.D. and Trapani,J.A.
    Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
    J Leukoc Biol60, 555-562. PubMed  Europe PubMed  V
    78. 1995
  78. Bochan,M.R., Goebel,W.S. and Brahmi,Z.
    Stably transfected antisense granzyme B and perforin constructs inhibit human granule-mediated lytic ability
    Cell Immunol164, 234-239. PubMed  Europe PubMed DOI
  79. Quan,L.T., Caputo,A., Bleackley,R.C., Pickup,D.J. and Salvesen,G.S.
    Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
    J Biol Chem270, 10377-10379. PubMed  Europe PubMed DOI
    80. 1994
  80. Caputo,A., James,M.N., Powers,J.C., Hudig,D. and Bleackley,R.C.
    Conversion of the substrate specificity of mouse proteinase granzyme B
    Nat Struct Biol1, 364-367. PubMed  Europe PubMed
  81. Peitsch,M.C. and Tschopp,J.
    Granzyme B
    Methods Enzymol244, 80-87. PubMed  Europe PubMed DOI  V
    82. 1991
  82. Ebnet,K., Chluba-de Tapia,J., Hurtenbach,U., Kramer,M.D. and Simon,M.M.
    In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C
    Int Immunol3, 9-19. PubMed  Europe PubMed
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    Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
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