Literature for peptidase M67.006: STAMBP isopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, T Target, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Yang,Y., Zhao,S., Jing,F., Xiong,Z., Li,M. and Xia,J. STAMBP drives colorectal cancer progression via CXCR4 deubiquitination and bone marrow-derived suppressor cell recruitment Genes Immun (2026) PubMed Europe PubMed DOI

2025

Makhlouf,L. and Zeqiraj,E. Unlocking the MIT gate: STAM activates AMSH autoinhibition Structure (2025) 33, 1289-1290. PubMed Europe PubMed DOI
Zhang,H., Han,Y., Wang,J., Wang,C., Chang,Z., Xiang,J., Hu,H., Yuan,Z., Zhang,N., Wang,Y., Zhang,C., Liu,Y., Wu,C., Ma,J., Zhou,X. and Wang,G. Lactylation-stabilized NOL6 promotes colorectal cancer progression via STAMBP-mediated YY1 deubiquitination and c-Myc transcription upregulation Cell Rep (2025) 45, 116774-116774. PubMed Europe PubMed DOI

2024

Hu,M., Li,J., Deng,J., Liu,C., Liu,Y., Li,H., Feng,W. and Xu,X. AAV-mediated Stambp gene replacement therapy rescues neurological defects in a mouse model of microcephaly-capillary malformation syndrome Mol Ther (2024) 32, 4095-4107. PubMed Europe PubMed DOI

2023

Li,L., Yang,X., He,M., Xu,X., Xuan,X., Zhang,J., Zhang,L., Xu,H. and Li,D. The expression and clinical significance of STAMBP in breast cancer Mol Biol Rep (2023) 50, 899-906. PubMed Europe PubMed DOI K

2022

Hu,M., Li,H., Huang,Z., Li,D., Xu,Y., Xu,Q., Chen,B., Wang,Y., Deng,J., Zhu,M., Feng,W. and Xu,X. Novel compound heterozygous mutation in STAMBP causes a neurodevelopmental disorder by disrupting cortical proliferation Front Neurosci (2022) 16, 963813-963813. PubMed Europe PubMed DOI PMC EPMC
Pan,X., Wu,S., Wei,W., Chen,Z., Wu,Y. and Gong,K. Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease Biomolecules (2022) 12 PubMed Europe PubMed DOI PMC EPMC V

2021

Guo,Y., Liu,Q., Mallette,E., Caba,C., Hou,F., Fux,J., LaPlante,G., Dong,A., Zhang,Q., Zheng,H., Tong,Y. and Zhang,W. Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1 J Biol Chem (2021) 297, 101107-101107. PubMed Europe PubMed DOI

2018

Iwakami,Y., Yokoyama,S., Watanabe,K. and Hayakawa,Y. STAM-binding protein regulates melanoma metastasis through SLUG stabilization Biochem Biophys Res Commun (2018) 507, 484-488. PubMed Europe PubMed DOI K T
Li,J., Zhang,Y., Da Silva Sil Dos Santos,B., Wang,F., Ma,Y., Perez,C., Yang,Y., Peng,J., Cohen,S.M., Chou,T.F., Hilton,S.T. and Deshaies,R.J. Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11 Cell Chem Biol (2018) 25, 1350-1358. PubMed Europe PubMed DOI I
Schultz-Larsen,T., Lenk,A., Kalinowska,K., Vestergaard,L.K., Pedersen,C., Isono,E. and Thordal-Christensen,H. The AMSH3 ESCRT-III-associated deubiquitinase is essential for plant immunity Cell Rep (2018) 25, 2329-2338. PubMed Europe PubMed DOI

2017

[YEAR:11-5-2017]Bednash,J.S., Weathington,N., Londino,J., Rojas,M., Gulick,D.L., Fort,R., Han,S., McKelvey,A.C., Chen,B.B. and Mallampalli,R.K. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity Nat Commun (11-5-2017) 8, 15203-15203. PubMed Europe PubMed I
Lauinger,L., Li,J., Shostak,A., Cemel,I.A., Ha,N., Zhang,Y., Merkl,P.E., Obermeyer,S., Stankovic-Valentin,N., Schafmeier,T., Wever,W.J., Bowers,A.A., Carter,K.P., Palmer,A.E., Tschochner,H., Melchior,F., Deshaies,R.J., Brunner,M. and Diernfellner,A. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases Nat Chem Biol (2017) 13, 709-714. PubMed Europe PubMed DOI I

2015

Zhu,W., Liu,Y. and Ling,B. Quantum mechanics and molecular mechanics study of the catalytic mechanism of human AMSH-LP domain deubiquitinating enzymes Biochemistry (2015) 54, 5225-5234. PubMed Europe PubMed DOI

2013

McDonell,L.M., Mirzaa,G.M., Alcantara,D., Schwartzentruber,J., Carter,M.T., Lee,L.J., Clericuzio,C.L., Graham,J.M., Jr., Morris-Rosendahl,D.J., Polster,T., Acsadi,G., Townshend,S., Williams,S., Halbert,A., Isidor,B., David,A., Smyser,C.D., Paciorkowski,A.R., Willing,M., Woulfe,J., Das,S., Beaulieu,C.L., Marcadier,J., Geraghty,M.T., Frey,B.J., Majewski,J., Bulman,D.E., Dobyns,W.B., O'Driscoll,M. and Boycott,K.M. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome Nat Genet (2013) 45, 556-562. PubMed Europe PubMed DOI M

2011

Wright,M.H., Berlin,I. and Nash,P.D. Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination Cell Biochem Biophys (2011) 60, 39-46. PubMed Europe PubMed DOI

2008

Sato,Y., Yoshikawa,A., Yamagata,A., Mimura,H., Yamashita,M., Ookata,K., Nureki,O., Iwai,K., Komada,M. and Fukai,S. Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Nature (2008) 455, 358-362. PubMed Europe PubMed DOI S

2006

McCullough,J., Row,P.E., Lorenzo,O., Doherty,M., Beynon,R., Clague,M.J. and Urbe,S. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery Curr Biol (2006) 16, 160-165. PubMed Europe PubMed DOI
Urbe,S., McCullough,J., Row,P., Prior,I.A., Welchman,R. and Clague,M.J. Control of growth factor receptor dynamics by reversible ubiquitination Biochem Soc Trans (2006) 34, 754-756. PubMed Europe PubMed DOI

2004

Li,H. and Seth,A. An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein Oncogene (2004) 23, 1801-1808. PubMed Europe PubMed DOI
[YEAR:16-9-2004]McCullough,J., Clague,M.J. and Urbe,S. AMSH is an endosome-associated ubiquitin isopeptidase J Cell Biol (16-9-2004) 166, 487-492. PubMed Europe PubMed DOI PMC EPMC

2001

Itoh,F., Asao,H., Sugamura,K., Heldin,C.H., ten,D.i. and Itoh,S. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads EMBO J (2001) 20, 4132-4142. PubMed Europe PubMed DOI PMC EPMC

1999

Tanaka,N., Kaneko,K., Asao,H., Kasai,H., Endo,Y., Fujita,T., Takeshita,T. and Sugamura,K. Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines J Biol Chem (1999) 274, 19129-19135. PubMed Europe PubMed DOI