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Literature for peptidase M41.003: m-AAA peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Fremlen,H. and Burmann,B.M.<br>Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases<br>Chembiochem (2025) , e202500048-e202500048. PubMed  Europe PubMed DOI  V
    2. 2023
  2. Matsushima,Y.<br>Mitochondrial AAA+ proteases<br>Enzymes (2023) 54, 205-220. PubMed  Europe PubMed DOI
    3. 2022
  3. Heidorn-Czarna,M., Maziak,A. and Janska,H.<br>Protein Processing in Plant Mitochondria Compared to Yeast and Mammals<br>Front Plant Sci (2022) 13, 824080-824080. PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2018
  4. Opalinska,M. and Janska,H.<br>AAA Proteases: guardians of mitochondrial function and homeostasis<br>Cells (2018) 7, 163-163. PubMed  Europe PubMed DOI
  5. Patron,M., Sprenger,H.G. and Langer,T.<br>m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration<br>Cell Res (2018) 28, 296-306. PubMed  Europe PubMed DOI
    6. 2017
  6. Lee,S., Lee,H., Yoo,S. and Kim,H.<br>Molecular insights into the m-AAA protease-mediated dislocation of transmembrane helices in the mitochondrial inner membrane<br>J Biol Chem (2017) 292, 20058-20066. PubMed  Europe PubMed DOI
  7. Tsai,C.W., Wu,Y., Pao,P.C., Phillips,C.B., Williams,C., Miller,C., Ranaghan,M. and Tsai,M.F.<br>Proteolytic control of the mitochondrial calcium uniporter complex<br>Proc Natl Acad Sci U S A (2017) 114, 4388-4393. PubMed  Europe PubMed DOI
    8. 2016
  8. Konig,T., Troder,S.E., Bakka,K., Korwitz,A., Richter-Dennerlein,R., Lampe,P.A., Patron,M., Muhlmeister,M., Guerrero-Castillo,S., Brandt,U., Decker,T., Lauria,I., Paggio,A., Rizzuto,R., Rugarli,E.I., De Stefani,D. and Langer,T.<br>The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria<br>Mol Cell (2016) 64, 148-162. PubMed  Europe PubMed DOI
  9. Wang,S., Jacquemyn,J., Murru,S., Martinelli,P., Barth,E., Langer,T., Niessen,C.M. and Rugarli,E.I.<br>The mitochondrial m-AAA protease prevents demyelination and hair greying<br>PLoS Genet (2016) 12, e1006463-e1006463. PubMed  Europe PubMed DOI  K
    10. 2013
  10. Botelho,S.C., Tatsuta,T., von Heijne,G. and Kim,H.<br>Dislocation by the m-AAA protease increases the threshold hydrophobicity for retention of transmembrane helices in the inner membrane of yeast mitochondria<br>J Biol Chem (2013) 288, 4792-4798. PubMed  Europe PubMed DOI
    11. 2012
  11. Gerdes,F., Tatsuta,T. and Langer,T.<br>Mitochondrial AAA proteases - towards a molecular understanding of membrane-bound proteolytic machines<br>Biochim Biophys Acta (2012) 1823, 49-55. PubMed  Europe PubMed DOI
  12. Thorsness,M.K. and Thorsness,P.E.<br>Mitochondrial m-protease<br>[ISSN:978-0-12-407744-7] (2012) 3, 692-695. DOI
    13. 2011
  13. Bonn,F., Tatsuta,T., Petrungaro,C., Riemer,J. and Langer,T.<br>Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria<br>EMBO J (2011) 30, 2545-2556. PubMed  Europe PubMed DOI
  14. Guha,S., Lopez-Maury,L., Shaw,M., Bahler,J., Norbury,C.J. and Agashe,V.R.<br>Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeast<br>J Mol Biol (2011) 408, 222-237. PubMed  Europe PubMed DOI
  15. Lee,S., Augustin,S., Tatsuta,T., Gerdes,F., Langer,T. and Tsai,F.T.<br>Electron cryomicroscopy structure of a membrane-anchored mitochondrial AAA protease<br>J Biol Chem (2011) 286, 4404-4411. PubMed  Europe PubMed DOI  S
    16. 2010
  16. Truscott,K.N., Lowth,B.R., Strack,P.R. and Dougan,D.A.<br>Diverse functions of mitochondrial AAA+ proteins: protein activation, disaggregation, and degradation<br>Biochem Cell Biol (2010) 88, 97-108. PubMed  Europe PubMed DOI
    17. 2009
  17. Augustin,S., Gerdes,F., Lee,S., Tsai,F.T., Langer,T. and Tatsuta,T.<br>An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases<br>Mol Cell (2009) 35, 574-585. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S., Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and Langer,T.<br>Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1<br>J Cell Biol (2009) 187, 1023-1036. PubMed  Europe PubMed DOI
  19. Koppen,M., Bonn,F., Ehses,S. and Langer,T.<br>Autocatalytic processing of m-AAA protease subunits in mitochondria<br>Mol Biol Cell (2009) 20, 4216-4224. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Kress,W. and Weber-Ban,E.<br>The alternating power stroke of a 6-cylinder AAA protease chaperone engine<br>Mol Cell (2009) 35, 545-547. PubMed  Europe PubMed DOI
  21. Short,B.<br>Mitochondrial proteases strike the right balance. Two studies reveal how proteases combine to regulate mitochondrial fusion<br>J Cell Biol (2009) 187, 937-937. DOI
  22. Suppanz,I.E., Wurm,C.A., Wenzel,D. and Jakobs,S.<br>The m-AAA protease processes cytochrome c peroxidase preferentially at the inner boundary membrane of mitochondria<br>Mol Biol Cell (2009) 20, 572-580. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Tatsuta,T. and Langer,T.<br>AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines<br>Res Microbiol (2009) 160, 711-717. PubMed  Europe PubMed DOI
    24. 2007
  24. Duvezin-Caubet,S., Koppen,M., Wagener,J., Zick,M., Israel,L., Bernacchia,A., Jagasia,R., Rugarli,E.I., Imhof,A., Neupert,W., Langer,T. and Reichert,A.S.<br>OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria<br>Mol Biol Cell (2007) 18, 3582-3590. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Koppen,M. and Langer,T.<br>Protein degradation within mitochondria: versatile activities of AAA proteases and other peptidases<br>Crit Rev Biochem Mol Biol (2007) 42, 221-242. PubMed  Europe PubMed DOI  V
  26. [YEAR:24-1-2007]Tatsuta,T., Augustin,S., Nolden,M., Friedrichs,B. and Langer,T.<br>m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria<br>EMBO J (24-1-2007) 26, 325-335. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2006
  27. Erzberger,J.P. and Berger,J.M.<br>Evolutionary relationships and structural mechanisms of AAA+ proteins<br>Annu Rev Biophys Biomol Struct (2006) 35, 93-114. PubMed  Europe PubMed DOI
  28. [YEAR:27-4-2006]Rugarli,E.I. and Langer,T.<br>Translating m-AAA protease function in mitochondria to hereditary spastic paraplegia<br>Trends Mol Med (27-4-2006) 12, 262-269. PubMed  Europe PubMed DOI  V
    29. 2004
  29. Thorsness,M.K. and Thorsness,P.E.<br>Mitochondrial m- and i-AAA proteases<br>[ISSN:0-12-079610-4] (2004) 2, 798-801.  V
    30. 2002
  30. [YEAR:2-9-2002]Arnold,I. and Langer,T.<br>Membrane protein degradation by AAA proteases in mitochondria<br>Biochim Biophys Acta (2-9-2002) 1592, 89-96. PubMed  Europe PubMed DOI
  31. [YEAR:8-11-2002]Esser,K., Tursun,B., Ingenhoven,M., Michaelis,G. and Pratje,E.<br>A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex and the putative Rhomboid protease Pcp1<br>J Mol Biol (8-11-2002) 323, 835-843. PubMed  Europe PubMed DOI
    32. 2001
  32. Klanner,C., Prokisch,H. and Langer,T.<br>MAP-1 and IAP-1, two novel AAA proteases with catalytic sites on opposite membrane surfaces in mitochondrial inner membrane of Neurospora crassa<br>Mol Biol Cell (2001) 12, 2858-2869. PubMed  Europe PubMed  PMC  EPMC
  33. Langer,T., Kaser,M., Klanner,C. and Leonhard,K.<br>AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis<br>Biochem Soc Trans (2001) 29, 431-436. PubMed  Europe PubMed DOI
    34. 2000
  34. [YEAR:15-9-2000]Juhola,M.K., Shah,Z.H., Grivell,L.A. and Jacobs,H.T.<br>The mitochondrial inner membrane AAA metalloprotease family in metazoans<br>FEBS Lett (15-9-2000) 481, 91-95. PubMed  Europe PubMed DOI
  35. Leonhard,K., Guiard,B., Pellecchia,G., Tzagoloff,A., Neupert,W. and Langer,T.<br>Membrane protein degradation by AAA proteases in mitochondria: extraction of substrates from either membrane surface<br>Mol Cell (2000) 5, 629-638. PubMed  Europe PubMed
    36. 1999
  36. Steglich,G., Neupert,W. and Langer,T.<br>Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria<br>Mol Cell Biol (1999) 19, 3435-3442. PubMed  Europe PubMed  PMC  EPMC
    37. 1998
  37. [YEAR:17-8-1998]Arlt,H., Steglich,G., Perryman,R., Guiard,B., Neupert,W. and Langer,T.<br>The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease<br>EMBO J (17-8-1998) 17, 4837-4847. PubMed  Europe PubMed DOI  PMC  EPMC
  38. [YEAR:7-8-1998]Savel'ev,A.S., Novikova,L.A., Kovaleva,I.E., Luzikov,V.N., Neupert,W. and Langer,T.<br>ATP-dependent proteolysis in mitochondria. m-AAA protease and PIM1 protease exert overlapping substrate specificities and cooperate with the mtHsp70 system<br>J Biol Chem (7-8-1998) 273, 20596-20602. PubMed  Europe PubMed DOI
    39. 1997
  39. Suzuki,C.K., Rep,M., van Dijl,J.M., Suda,K., Grivell,L.A. and Schatz,G.<br>ATP-dependent proteases that also chaperone protein biogenesis<br>Trends Biochem Sci (1997) 22, 118-123. PubMed  Europe PubMed DOI  V
    40. 1996
  40. Arlt,H., Tauer,R., Feldmann,H., Neupert,W. and Langer,T.<br>The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria<br>Cell (1996) 85, 875-885. PubMed  Europe PubMed DOI
  41. Langer,T. and Neupert,W.<br>Regulated protein degradation in mitochondria<br>Experientia (1996) 52, 1069-1076. PubMed  Europe PubMed DOI
  42. Leonhard,K., Herrmann,J.M., Stuart,R.A., Mannhaupt,G., Neupert,W. and Langer,T.<br>AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria<br>EMBO J (1996) 15, 4218-4229. PubMed  Europe PubMed  PMC  EPMC
  43. Rep,M., Nooy,J., Guelin,E. and Grivell,L.A.<br>Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed<br>Curr Genet (1996) 30, 206-211. PubMed  Europe PubMed DOI
  44. Rep,M., van Dijl,J.M., Suda,K., Schatz,G., Grivell,L.A. and Suzuki,C.K.<br>Promotion of mitochondrial membrane complex assembly by a proteolytically inactive yeast Lon<br>Science (1996) 274, 103-106. PubMed  Europe PubMed DOI
    45. 1995
  45. [YEAR:2-10-1995]Paul,M.F. and Tzagoloff,A.<br>Mutations in RCA1 and AFG3 inhibit F1-ATPase assembly in Saccharomyces cerevisiae<br>FEBS Lett (2-10-1995) 373, 66-70. PubMed  Europe PubMed DOI

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