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Literature for peptidase M15.011: vanX D-Ala-D-Ala dipeptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, M Mutation, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Konuma,T., Takai,T., Tsuchiya,C., Nishida,M., Hashiba,M., Yamada,Y., Shirai,H., Motoda,Y., Nagadoi,A., Chikaishi,E., Akagi,K.I., Akashi,S., Yamazaki,T., Akutsu,H. and Ikegami,T.
    Analysis of the homodimeric structure of a D-Ala-D-Ala metallopeptidase, VanX, from vancomycin-resistant bacteria
    Protein Sci33, e5002-e5002. PubMed  Europe PubMed DOI
    2. 2019
  2. Lv,M., Zhang,Y.J., Zhou,F., Ge,Y., Zhao,M.H., Liu,Y. and Yang,K.W.
    Real-time monitoring of D-Ala-D-Ala dipeptidase activity of VanX in living bacteria by isothermal titration calorimetry
    Anal Biochem578, 29-35. PubMed  Europe PubMed DOI  A
    3. 2018
  3. Binda,E., Cappelletti,P., Marinelli,F. and Marcone,G.L.
    Specificity of induction of glycopeptide antibiotic resistance in the producing actinomycetes
    Antibiotics (Basel)7, 36-36. PubMed  Europe PubMed DOI
  4. Hansen,T.A., Pedersen,M.S., Nielsen,L.G., Ma,C.M.G., Soes,L.M., Worning,P., Ostergaard,C., Westh,H., Pinholt,M. and Schonning,K.
    Emergence of a vancomycin-variable Enterococcus faecium ST1421 strain containing a deletion in vanX
    J Antimicrob Chemother73, 2936-2940. PubMed  Europe PubMed DOI  M
    5. 2016
  5. van der Aart,L.T., Lemmens,N., Van Wamel,W.J. and van Wezel,G.P.
    Substrate inhibition of VanA by D-alanine reduces vancomycin resistance in a VanX-dependent manner
    Antimicrob Agents Chemother60, 4930-4939. PubMed  Europe PubMed DOI
  6. Wu,N., Kamioka,T. and Kuroda,Y.
    A novel screening system based on VanX-mediated autolysis-Application to Gaussia luciferase
    Biotechnol Bioeng113, 1413-1420. PubMed  Europe PubMed DOI
    7. 2014
  7. Muthyala,R., Rastogi,N., Shin,W.S., Peterson,M.L. and Sham,Y.Y.
    Cell permeable vanX inhibitors as vancomycin re-sensitizing agents
    Bioorg Med Chem Lett24, 2535-2538. PubMed  Europe PubMed DOI  I
  8. Sohya,S., Kamioka,T., Fujita,C., Maki,T., Ohta,Y. and Kuroda,Y.
    Biochemical and biophysical characterization of an unexpected bacteriolytic activity of VanX, a member of the vancomycin-resistance vanA gene cluster
    J Biol Chem289, 35686-35694. PubMed  Europe PubMed DOI
    9. 2013
  9. Kamioka,T., Sohya,S., Wu,N., Maki,T., Matsuda,T., Ikegami,T., Nakamura,H. and Kuroda,Y.
    Extraction of recombinant protein from Escherichia coli by using a novel cell autolysis activity of VanX
    Anal Biochem439, 212-217. PubMed  Europe PubMed DOI
    10. 2012
  10. Jia,C., Yang,K.W., Liu,C.C., Feng,L., Xiao,J.M., Zhou,L.S. and Zhang,Y.L.
    Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX
    Bioorg Med Chem Lett22, 482-484. PubMed  Europe PubMed DOI  I
  11. Lessard,I.A.D.
    VanX D-,D-dipeptidase
    [ISSN:978-0-12-407744-7]3, 1395-1401. DOI
    12. 2011
  12. Yang,K.W., Cheng,X., Zhao,C., Liu,C.C., Jia,C., Feng,L., Xiao,J.M., Zhou,L.S., Gao,H.Z., Yang,X. and Zhai,L.
    Synthesis and activity study of phosphonamidate dipeptides as potential inhibitors of VanX
    Bioorg Med Chem Lett21, 7224-7227. PubMed  Europe PubMed DOI  I
    13. 2006
  13. [YEAR:24-8-2006]Chang,Y.P., Tseng,M.J. and Chu,Y.H.
    Using surface plasmon resonance to directly measure slow binding of low-molecular mass inhibitors to a VanX chip
    Anal Biochem359, 63-71. PubMed  Europe PubMed DOI  I
  14. Crowder,M.W.
    Combating vancomycin resistance in bacteria: targeting the D-ala-D-ala dipeptidase VanX
    Infect Disord Drug Targets6, 147-158. PubMed  Europe PubMed DOI  T
  15. [YEAR:27-4-2006]Hsieh,M.L., Tseng,M.J., Tseng,M.C. and Chu,Y.H.
    Identification of a new chromophoric substrate in the library of amino acid p-nitroanilides for continuous assay of VanX, a d,d-dipeptidase essential for vancomycin resistance
    Anal Biochem354, 104-110. PubMed  Europe PubMed DOI  A
  16. [YEAR:11-10-2006]Matthews,M.L., Periyannan,G., Hajdin,C., Sidgel,T.K., Bennett,B. and Crowder,M.W.
    Probing the reaction mechanism of the d-ala-d-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme
    J Am Chem Soc128, 13050-13051. PubMed  Europe PubMed DOI
    17. 2005
  17. [YEAR:17-1-2005]Breece,R.M., Costello,A., Bennett,B., Sigdel,T.K., Matthews,M.L., Tierney,D.L. and Crowder,M.W.
    A five-coordinate metal center in Co(II)-substituted VanX
    J Biol Chem280, 11074-11081. PubMed  Europe PubMed DOI
    18. 2004
  18. [YEAR:15-8-2004]Golich,F.C., Sigdel,T., Breece,R.M., Detar,L., Herron,L.R. and Crowder,M.W.
    L-alanine-p-nitroanilide is not a substrate for VanX
    Anal Biochem331, 398-400. PubMed  Europe PubMed DOI
  19. Lessard,I.A.D.
    VanX D-,D-dipeptidase
    [ISSN:0-12-079610-4]2, 860-866.  V
    20. 2003
  20. Anissimova,M., Yaouancq,L., Noor,F., Badet-Denisot,M.A. and Badet,B.
    New chromogenic dipeptide substrate for continuous assay of the D-alanyl-D-alanine dipeptidase VanX required for high-level vancomycin resistance
    J Pept Res62, 88-95. PubMed  Europe PubMed DOI  A
    21. 2002
  21. Gao,Y.
    Glycopeptide antibiotics and development of inhibitors to overcome vancomycin resistance
    Nat Prod Rep19, 100-107. PubMed  Europe PubMed DOI  I
  22. Tan,A.L., Loke,P. and Sim,T.S.
    Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2)
    Res Microbiol153, 27-32. PubMed  Europe PubMed DOI
    23. 2000
  23. [YEAR:26-12-2000]Araoz,R., Anhalt,E., Rene,L., Badet-Denisot,M.A., Courvalin,P. and Badet,B.
    Mechanism-based inactivation of VanX, a D-alanyl-D-alanine dipeptidase necessary for vancomycin resistance
    Biochemistry39, 15971-15979. PubMed  Europe PubMed DOI
  24. Brandt,J.J., Chatwood,L.L. and Crowder,M.W.
    Analysis of three overexpression systems for VanX, the zinc(II) dipeptidase required for high-level vancomycin resistance in bacteria
    Protein Expr Purif20, 300-307. PubMed  Europe PubMed DOI  E
  25. Patel,R., Piper,K., Cockerill,F.R., III, Steckelberg,J.M. and Yousten,A.A.
    The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster
    Antimicrobial Agents Chemother44, 705-709. PubMed  Europe PubMed DOI
    26. 1999
  26. [YEAR:15-7-1999]Brandt,J.J., Chatwood,L.L., Yang,K.W. and Crowder,M.W.
    Continuous assay for VanX, the D-alanyl-D-alanine dipeptidase required for high-level vancomycin resistance
    Anal Biochem272, 94-99. PubMed  Europe PubMed DOI  A
  27. Hilbert,F., Del Portillo,F.G. and Groisman,E.A.
    A periplasmic D-alanyl-D-alanine dipeptidase in the gram-negative bacterium Salmonella enterica
    J Bacteriol181, 2158-2165. PubMed  Europe PubMed
  28. [YEAR:28-9-1999]Lessard,I.A. and Walsh,C.T.
    VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function?
    Proc Natl Acad Sci U S A96, 11028-11032. PubMed  Europe PubMed DOI
  29. Lessard,I.A. and Walsh,C.T.
    Mutational analysis of active-site residues of the enterococcal D-Ala-D-Ala dipeptidase VanX and comparison with Escherichia coli D-ala-D-Ala ligase and D-ala-D-Ala carboxypeptidase VanY
    Chem Biol6, 177-187. PubMed  Europe PubMed DOI
    30. 1998
  30. Arthur,M., Depardieu,F., Cabanie,L., Reynolds,P. and Courvalin,P.
    Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci
    Mol Microbiol30, 819-830. PubMed  Europe PubMed DOI
  31. Bussiere,D.E., Pratt,S.D., Katz,L., Severin,J.M., Holzman,T. and Park,C.H.
    The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance
    Mol Cell2, 75-84. PubMed  Europe PubMed  S
  32. Lessard,I.A., Pratt,S.D., McCafferty,D.G., Bussiere,D.E., Hutchins,C., Wanner,B.L., Katz,L. and Walsh,C.T.
    Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function
    Chem Biol5, 489-504. PubMed  Europe PubMed
  33. Reynolds,P.E.
    Control of peptidoglycan synthesis in vancomycin-resistant enterococci: D,D-peptidases and D,D-carboxypeptidases
    Cell Mol Life Sci54, 325-331. PubMed  Europe PubMed DOI
  34. [YEAR:15-11-1998]Tu,J. and Chu,Y.H.
    Vancomycin resistance in Enterococcus faecium: a capillary electrophoresis-based assay for VanX enzyme
    Anal Biochem264, 293-296. PubMed  Europe PubMed DOI  A
    35. 1997
  35. McCafferty,D.G., Lessard,I.A. and Walsh,C.T.
    Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX
    Biochemistry36, 10498-10505. PubMed  Europe PubMed DOI
    36. 1996
  36. Walsh,C.T., Fisher,S.L., Park,I.S., Prahalad,M. and Wu,Z.
    Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story
    Chem Biol3, 21-28. PubMed  Europe PubMed
  37. Wu,Z. and Walsh,C.
    Dithiol compounds: potent, time-dependent inhibitors of VanX, a zinc-dependent D,D-dipeptidase required for vancomycin resistance in Enterococcus faecium
    J Am Chem Soc118, 1785-1786.  I
    38. 1995
  38. Wu,Z. and Walsh,C.T.
    Phosphinate analogs of D-, D-dipeptides: Slow-binding inhibition and proteolysis protection of VanX, a D-, D-dipeptidase required for vancomycin resistance in Enterococcus faecium
    Proc Natl Acad Sci U S A92, 11603-11607. PubMed  Europe PubMed DOI
  39. Wu,Z., Wright,G.D. and Walsh,C.T.
    Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147
    Biochemistry34, 2455-2463. PubMed  Europe PubMed
    40. 1994
  40. Reynolds,P.E., Depardieu,F., Dutka-Malen,S., Arthur,M. and Courvalin,P.
    Glycopeptide resistance mediated by enterococcal transposon tn1546 requires production of vanX for hydrolysis of D-alanyl-D- alanine
    Mol Microbiol13, 1065-1070. PubMed  Europe PubMed
    41. 1993
  41. [YEAR:16-7-1993]Walsh,C.T.
    Vancomycin resistance: decoding the molecular logic
    Science261, 308-309. PubMed  Europe PubMed

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