Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M14.028: cytosolic carboxypeptidase 1

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Bak,J., Brummelkamp,T.R. and Perrakis,A.
    Decoding microtubule detyrosination: enzyme families, structures, and functional implications
    FEBS Lett598, 1453-1464. PubMed  Europe PubMed DOI  V
  2. Li,D.Z., Yang,Z.Y., Leng,A., Zhang,Q., Zhang,X.D., Bian,Y.C., Xiao,R. and Ren,J.J.
    Targeting AGTPBP1 inhibits pancreatic cancer progression via regulating microtubules and ERK signaling pathway
    Mol Med30, 119-119. PubMed  Europe PubMed DOI  K
    3. 2022
  3. Landskron,L., Bak,J., Adamopoulos,A., Kaplani,K., Moraiti,M., van den Hengel,L.G., Song,J.Y., Bleijerveld,O.B., Nieuwenhuis,J., Heidebrecht,T., Henneman,L., Moutin,M.J., Barisic,M., Taraviras,S., Perrakis,A. and Brummelkamp,T.R.
    Posttranslational modification of microtubules by the MATCAP detyrosinase
    Science376, eabn6020-eabn6020. PubMed  Europe PubMed DOI
    4. 2021
  4. Koyanagi,T., Saga,Y., Takahashi,Y., Tamura,K., Yoshiba,T., Takahashi,S., Taneichi,A., Takei,Y., Urabe,M., Mizukami,H. and Fujiwara,H.
    Knockout of vasohibin-2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer
    Cancer Med10, 2732-2739. PubMed  Europe PubMed DOI
    5. 2019
  5. Freund,R.R.A., Gobrecht,P., Rao,Z., Gerstmeier,J., Schlosser,R., Gorls,H., Werz,O., Fischer,D. and Arndt,H.D.
    Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity
    Chem Sci10, 7358-7364. PubMed  Europe PubMed DOI  I
    6. 2018
  6. Zhou,L., Hossain,M.I., Yamazaki,M., Abe,M., Natsume,R., Konno,K., Kageyama,S., Komatsu,M., Watanabe,M., Sakimura,K. and Takebayashi,H.
    Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype
    J Neurochem147, 557-572. PubMed  Europe PubMed DOI
    7. 2015
  7. Song,N., Kim,N., Xiao,R., Choi,H., Chun,H.I., Kang,M.H., Kim,J.H., Seo,K., Soundrarajan,N., Do,J.T., Song,H., Ge,Z.J. and Park,C.
    Lack of cytosolic carboxypeptidase 1 leads to subfertility due to the reduced number of antral follicles in pcd3J-/- females
    PLoS ONE10, e0139557-e0139557. PubMed  Europe PubMed DOI
  8. Tanco,S., Tort,O., Demol,H., Aviles,F.X., Gevaert,K., Van Damme,P. and Lorenzo,J.
    C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini
    Mol Cell Proteomics14, 177-190. PubMed  Europe PubMed DOI  P
    9. 2013
  9. Rodriguez de la Vega Otazo, Lorenzo,J., Tort,O., Aviles,F.X. and Bautista,J.M.
    Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs)
    FASEB J27, 424-431. PubMed  Europe PubMed DOI
    10. 2012
  10. Berezniuk,I., Vu,H.T., Lyons,P.J., Sironi,J.J., Xiao,H., Burd,B., Setou,M., Angeletti,R.H., Ikegami,K. and Fricker,L.D.
    Cytosolic carboxypeptidase 1 is involved in processing alpha- and beta-tubulin
    J Biol Chem287, 6503-6517. PubMed  Europe PubMed DOI
  11. Webster,D.R.
    Tubulinyl-Tyr carboxypeptidase
    [ISSN:978-0-12-407744-7]3, 1385-1389. DOI
    12. 2010
  12. Berezniuk,I. and Fricker,L.D.
    A defect in cytosolic carboxypeptidase 1 (Nna1) causes autophagy in Purkinje cell degeneration mouse brain
    Autophagy6, 558-559. PubMed  Europe PubMed DOI  M
  13. Rogowski,K., van Dijk,J., Magiera,M.M., Bosc,C., Deloulme,J.C., Bosson,A., Peris,L., Gold,N.D., Lacroix,B., Grau,M.B., Bec,N., Larroque,C., Desagher,S., Holzer,M., Andrieux,A., Moutin,M.J. and Janke,C.
    A family of protein-deglutamylating enzymes associated with neurodegeneration
    Cell143, 564-578. PubMed  Europe PubMed DOI
    14. 2007
  14. Fonrose,X., Ausseil,F., Soleilhac,E., Masson,V., David,B., Pouny,I., Cintrat,J.C., Rousseau,B., Barette,C., Massiot,G. and Lafanechere,L.
    Parthenolide inhibits tubulin carboxypeptidase activity
    Cancer Res67, 3371-3378. PubMed  Europe PubMed DOI
  15. Kalinina,E., Biswas,R., Berezniuk,I., Hermoso,A., Aviles,F.X. and Fricker,L.D.
    A novel subfamily of mouse cytosolic carboxypeptidases
    FASEB J21, 836-850. PubMed  Europe PubMed DOI
  16. Rodriguez de la Vega,M., Sevilla,R.G., Hermoso,A., Lorenzo,J., Tanco,S., Diez,A., Fricker,L.D., Bautista,J.M. and Aviles,F.X.
    Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily
    FASEB J21, 851-865. PubMed  Europe PubMed DOI
    17. 2004
  17. Webster,D.R.
    Tubulinyl-Tyr carboxypeptidase
    [ISSN:0-12-079610-4]2, 2111-2113.  V
    18. 2003
  18. Contin,M.A., Purro,S.A., Bisig,C.G., Barra,H.S. and Arce,C.A.
    Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules
    Eur J Biochem270, 4921-4929. PubMed  Europe PubMed DOI
    19. 2002
  19. [YEAR:23-8-2002]Chang,W., Webster,D.R., Salam,A.A., Gruber,D., Prasad,A., Eiserich,J.P. and Bulinski,J.C.
    Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation
    J Biol Chem277, 30690-30698. PubMed  Europe PubMed DOI
  20. Lin,S.X., Gundersen,G.G. and Maxfield,F.R.
    Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (Glu) microtubules and kinesin
    Mol Biol Cell13, 96-109. PubMed  Europe PubMed DOI
    21. 2001
  21. [YEAR:1-7-2001]Mialhe,A., Lafanechere,L., Treilleux,I., Peloux,N., Dumontet,C., Bremond,A., Panh,M.H., Payan,R., Wehland,J., Margolis,R.L. and Job,D.
    Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis
    Cancer Res61, 5024-5027. PubMed  Europe PubMed
    22. 2000
  22. Contin,M.A. and Arce,C.A.
    Tubulin carboxypeptidase/microtubules association can be detected in the distal region of neural processes
    Neurochem Res25, 27-36. PubMed  Europe PubMed DOI
  23. [YEAR:1-3-2000]Sironi,J.J., Barra,H.S. and Arce,C.A.
    Tubulin carboxypeptidase assay based on the action of the enzyme on [14C]tyrosinated tubulin bound to nitrocellulose membrane
    Anal Biochem279, 9-17. PubMed  Europe PubMed DOI  A
    24. 1999
  24. [YEAR:15-4-1999]Contin,M.A., Sironi,J.J., Barra,H.S. and Arce,C.A.
    Association of tubulin carboxypeptidase with microtubules in living cells
    Biochem J339, 463-471. PubMed  Europe PubMed DOI
  25. Kreitzer,G., Liao,G. and Gundersen,G.G.
    Detyrosination of tubulin regulates the interaction of intermediate filaments with microtubules in vivo via a kinesin-dependent mechanism
    Mol Biol Cell10, 1105-1118. PubMed  Europe PubMed
    26. 1998
  26. [YEAR:17-4-1998]Liao,G. and Gundersen,G.G.
    Kinesin is a candidate for cross-bridging microtubules and intermediate filaments. Selective binding of kinesin to detyrosinated tubulin and vimentin
    J Biol Chem273, 9797-9803. PubMed  Europe PubMed DOI
    27. 1997
  27. Weizetfel,J.C., Smania,A.M., Barra,H.S. and Argarana,C.E.
    A brain protein (P30) that immunoreacts with a polyclonal anti-pancreatic carboxypeptidase A antibody shows properties that are shared with tubulin carboxypeptidase
    Mol Cell Biochem170, 139-146. PubMed  Europe PubMed DOI
    28. 1996
  28. Webster,D.R. and Oxford,M.G.
    Regulation of cytoplasmic tubulin carboxypeptidase activity in vitro by cations and sulfhydryl-modifying compounds
    J Cell Biochem60, 424-436. PubMed  Europe PubMed DOI  I
    29. 1995
  29. Gurland,G. and Gundersen,G.G.
    Stable, detyrosinated microtubules function to localize vimentin intermediate filaments in fibroblasts
    J Cell Biol131, 1275-1290. PubMed  Europe PubMed DOI
    30. 1992
  30. Smania,A.M., Argarana,C.E., Weizetfel,J.C. and Barra,H.S.
    Immunodetection of tubulin carboxypeptidase activity on nitrocellulose membrane after gel electrophoresis and blotting
    Biochem Int28, 921-928. PubMed  Europe PubMed
  31. Webster,D.R., Modesti,N.M. and Bulinski,J.C.
    Regulation of cytoplasmic tubulin carboxypeptidase activity during neural and muscle differentiation: characterization using a microtubule-based assay
    Biochemistry31, 5849-5856. PubMed  Europe PubMed
    32. 1990
  32. Webster,D.R., Wehland,J., Weber,K. and Borisy,G.G.
    Detyrosination of alpha tubulin does not stabilize microtubules in vivo
    J Cell Biol111, 113-122. PubMed  Europe PubMed DOI
    33. 1989
  33. [YEAR:15-3-1989]Weizetfel,J.C., Argarana,C.E., Beltramo,D.M. and Barra,H.S.
    The integrity of tubulin molecule is not required for the activity of tubulin carboxypeptidase
    Biochem Biophys Res Commun159, 770-776. PubMed  Europe PubMed
    34. 1987
  34. Wehland,J. and Weber,K.
    Turnover of the carboxy-terminal tyrosine of alpha-tubulin and means of reaching elevated levels of detyrosination in living cells
    J Cell Sci88, 185-203. PubMed  Europe PubMed
    35. 1983
  35. [YEAR:27-6-1983]Arce,C.A. and Barra,H.S.
    Association of tubulinyl-tyrosine carboxypeptidase with microtubules
    FEBS Lett157, 75-78. PubMed  Europe PubMed DOI
    36. 1981
  36. [YEAR:25-7-1981]Kumar,N. and Flavin,M.
    Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin
    J Biol Chem256, 7678-7686. PubMed  Europe PubMed
    37. 1980
  37. Argarana,C.E., Barra,H.S. and Caputto,R.
    Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification
    J Neurochem34, 114-118. PubMed  Europe PubMed
  38. Deanin,G.G., Preston,S.F., Hanson,R.K. and Gordon,M.W.
    On the mechanism of turnover of the carboxy-terminal tyrosine of the alpha chain of tubulin
    Eur J Biochem109, 207-216. PubMed  Europe PubMed
    39. 1978
  39. [YEAR:24-2-1978]Argarana,C.E., Barra,H.S. and Caputto,R.
    Release of [14C]tyrosine from tubulinyl-[14C]tyrosine by brain extract. Separation of a carboxypeptidase from tubulin-tyrosine ligase
    Mol Cell Biochem19, 17-21. PubMed  Europe PubMed
    40. 1977
  40. [YEAR:1-2-1977]Hallak,M.E., Rodriguez,J.A., Barra,H.S. and Caputto,R.
    Release of tyrosine from tyrosinated tubulin. Some common factors that affect this process and the assembly of tubulin
    FEBS Lett73, 147-150. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use