Literature for peptidase M12.208: ADAM8 peptidase

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Shen,K., Shan,Z., Li,Y., Ji,Z., Zhou,L. and Lv,Z.
   TFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway
   J Biochem Mol Toxicol39, e70097-e70097. PubMed  Europe PubMed DOI  K
2024
2. Chen,K., Tao,H., Zhu,P., Chu,M., Li,X., Shi,Y., Zhang,L., Xu,Y., Lv,S., Huang,L., Huang,W. and Geng,D.
   ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis
   Arthritis Res Ther26, 20-20. PubMed  Europe PubMed DOI
3. Qian,Z., Zhang,Q., Li,P., Li,Y., Zhang,Y., Li,R., Zhao,T., Xia,M., Chen,Y. and Hong,X.
   A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway
   Mol Neurobiol61, 3490-3502. PubMed  Europe PubMed DOI  K
2021
4. Alawak,M., Abu Dayyih,A., Mahmoud,G., Tariq,I., Duse,L., Goergen,N., Engelhardt,K., Reddy Pinnapireddy,S., Jedelska,J., Awak,M., Konig,A.M., Brussler,J., Bartsch,J.W. and Bakowsky,U.
   ADAM 8 as a Novel Target for Doxorubicin Delivery to TNBC Cells using Magnetic Thermosensitive Liposomes
   Eur J Pharm Biopharm158, 390-400. PubMed  Europe PubMed DOI
5. Awan,T., Babendreyer,A., Mahmood Alvi,A., Dusterhoft,S., Lambertz,D., Bartsch,J.W., Liedtke,C. and Ludwig,A.
   Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells
   J Cell Mol Med25, 1982-1999. PubMed  Europe PubMed DOI  K
6. Awan,T., Babendreyer,A., Wozniak,J., Alvi,A.M., Sterzer,V., Cook,L., Bartsch,J.W., Liedtke,C., Yildiz,D. and Ludwig,A.
   Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver Inflammation Models and Enhances Cytokine Release In Vitro
   Mediators Inflamm2021, 6665028-6665028. PubMed  Europe PubMed DOI  K
7. Jaworek,C., Verel-Yilmaz,Y., Driesch,S., Ostgathe,S., Cook,L., Wagner,S., Bartsch,D.K., Slater,E.P. and Bartsch,J.W.
   Cohort Analysis of ADAM8 Expression in the PDAC Tumor Stroma
   J Pers Med11, 113-113. PubMed  Europe PubMed DOI
8. Lu,H., Meng,Y., Han,X. and Zhang,W.
   ADAM8 Activates NLRP3 Inflammasome to Promote Cerebral Ischemia-Reperfusion Injury
   J Healthc Eng2021, 3097432-3097432. PubMed  Europe PubMed DOI
2020
9. Li,Y., Guo,S., Zhao,K., Conrad,C., Driescher,C., Rothbart,V., Schlomann,U., Guerreiro,H., Bopp,M.H., Konig,A., Carl,B., Pagenstecher,A., Nimsky,C. and Bartsch,J.W.
   ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesis
   Biol Chem402, 195-206. PubMed  Europe PubMed DOI
2019
10. Schlomann,U., Dorzweiler,K., Nuti,E., Tuccinardi,T., Rossello,A. and Bartsch,J.W.
    Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays
    Biol Chem400, 801-810. PubMed  Europe PubMed DOI  I
2018
11. Polverino,F., Rojas-Quintero,J., Wang,X., Petersen,H., Zhang,L., Gai,X., Higham,A., Zhang,D., Gupta,K., Rout,A., Yambayev,I., Pinto-Plata,V., Sholl,L.M., Cunoosamy,D., Celli,B.R., Goldring,J., Singh,D., Tesfaigzi,Y., Wedzicha,J., Olsson,H. and Owen,C.A.
    A disintegrin and metalloproteinase domain-8: a novel protective proteinase in chronic obstructive pulmonary disease
    Am J Respir Crit Care Med198, 1254-1267. PubMed  Europe PubMed DOI
2015
12. Kleino,I., Jarviluoma,A., Hepojoki,J., Huovila,A.P. and Saksela,K.
    Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions
    PLoS ONE10, e0121301-e0121301. PubMed  Europe PubMed DOI
2012
13. Bartsch,J.W. and Schlomann,U.
    ADAM8/MS2/CD156a
    [ISSN:978-0-12-407744-7]3, 1094-1101. DOI
14. Hall,T., Shieh,H.S., Day,J.E., Caspers,N., Chrencik,J.E., Williams,J.M., Pegg,L.E., Pauley,A.M., Moon,A.F., Krahn,J.M., Fischer,D.H., Kiefer,J.R., Tomasselli,A.G. and Zack,M.D.
    Structure of human ADAM-8 catalytic domain complexed with batimastat
    Acta Crystallogr Sect F Struct Biol Cryst Commun68, 616-621. PubMed  Europe PubMed DOI  S  I
15. Liang,J. and Kong,Q.
    alpha-Cleavage of cellular prion protein
    Prion6, 453-460. PubMed  Europe PubMed DOI
2011
16. Dominguez-Luis,M., Lamana,A., Vazquez,J., Garcia-Navas,R., Mollinedo,F., Sanchez-Madrid,F., Diaz-Gonzalez,F. and Urzainqui,A.
    The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins
    Eur J Immunol41, 3436-3442. PubMed  Europe PubMed DOI
17. Ishizuka,H., Garcia-Palacios,V., Lu,G., Subler,M.A., Zhang,H., Boykin,C.S., Choi,S.J., Zhao,L., Patrene,K., Galson,D.L., Blair,H.C., Hadi,T.M., Windle,J.J., Kurihara,N. and Roodman,G.D.
    ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo
    J Bone Miner Res26, 169-181. PubMed  Europe PubMed DOI
18. Paulissen,G., Rocks,N., Gueders,M.M., Bedoret,D., Crahay,C., Quesada-Calvo,F., Hacha,J., Bekaert,S., Desmet,C., Foidart,J.M., Bureau,F., Noel,A. and Cataldo,D.D.
    ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation
    Eur J Immunol41, 380-391. PubMed  Europe PubMed DOI
2010
19. Bartsch,J.W., Wildeboer,D., Koller,G., Naus,S., Rittger,A., Moss,M.L., Minai,Y. and Jockusch,H.
    Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection
    J Neurosci30, 12210-12218. PubMed  Europe PubMed DOI
20. Gossens,K., Naus,S., Hollander,G.A. and Ziltener,H.J.
    Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity
    PLoS ONE5, e12766-e12766. PubMed  Europe PubMed DOI
21. Guaiquil,V.H., Swendeman,S., Zhou,W., Guaiquil,P., Weskamp,G., Bartsch,J.W. and Blobel,C.P.
    ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice
    J Mol Med (Berl)88, 497-505. PubMed  Europe PubMed DOI
22. Hernandez,I., Moreno,J.L., Zandueta,C., Montuenga,L. and Lecanda,F.
    Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer
    Oncogene29, 3758-3769. PubMed  Europe PubMed DOI  M
23. Iida,A., Sakaguchi,K., Sato,K., Sakurai,H., Nishimura,D., Iwaki,A., Takeuchi,M., Kobayashi,M., Misaki,K., Yonemura,S., Kawahara,A. and Sehara-Fujisawa,A.
    Metalloprotease-dependent onset of blood circulation in zebrafish
    Curr Biol20, 1110-1116. PubMed  Europe PubMed DOI
24. Naus,S., Blanchet,M.R., Gossens,K., Zaph,C., Bartsch,J.W., McNagny,K.M. and Ziltener,H.J.
    The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma
    Am J Respir Crit Care Med181, 1318-1328. PubMed  Europe PubMed DOI  K  T
2009
25. Ainola,M., Li,T.F., Mandelin,J., Hukkanen,M., Choi,S.J., Salo,J. and Konttinen,Y.T.
    Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction
    Ann Rheum Dis68, 427-434. PubMed  Europe PubMed DOI
26. Hall,T., Leone,J.W., Wiese,J.F., Griggs,D.W., Pegg,L.E., Pauley,A.M., Tomasselli,A.G. and Zack,M.D.
    Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity
    Biosci Rep29, 217-228. PubMed  Europe PubMed DOI
27. Hall,T., Pegg,L.E., Pauley,A.M., Fischer,H.D., Tomasselli,A.G. and Zack,M.D.
    ADAM8 substrate specificity: influence of pH on pre-processing and proteoglycan degradation
    Arch Biochem Biophys491, 106-111. PubMed  Europe PubMed DOI
28. Knolle,M.D. and Owen,C.A.
    ADAM8: a new therapeutic target for asthma
    Expert Opin Ther Targets13, 523-540. PubMed  Europe PubMed DOI  V  T
29. Koller,G., Schlomann,U., Golfi,P., Ferdous,T., Naus,S. and Bartsch,J.W.
    ADAM8/MS2/CD156, an emerging drug target in the treatment of inflammatory and invasive pathologies
    Curr Pharm Des15, 2272-2281. PubMed  Europe PubMed DOI  T
30. Mahoney,E.T., Benton,R.L., Maddie,M.A., Whittemore,S.R. and Hagg,T.
    ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice
    J Comp Neurol512, 243-255. PubMed  Europe PubMed DOI
31. Yeh,H.Y. and Klesius,P.H.
    Channel catfish (Ictalurus punctatus Rafinesque, 1818) CD156a (ADAM metallopeptidase domain 8): cDNA clone, characterization and expression in tissues
    Vet Immunol Immunopathol132, 307-313. PubMed  Europe PubMed DOI  E
32. Zack,M.D., Melton,M.A., Stock,J.L., Storer,C.E., Barve,R.A., Minnerly,J.C., Weiss,D.J., Stejskal,J.A., Tortorella,M.D., Turk,J.R., Shevlin,K.M. and Malfait,A.M.
    Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8)
    Clin Exp Immunol158, 246-256. PubMed  Europe PubMed DOI  K
33. Zack,M.D., Malfait,A.M., Skepner,A.P., Yates,M.P., Griggs,D.W., Hall,T., Hills,R.L., Alston,J.T., Nemirovskiy,O.V., Radabaugh,M.R., Leone,J.W., Arner,E.C. and Tortorella,M.D.
    ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271)
    Arthritis Rheum60, 2704-2713. PubMed  Europe PubMed DOI  P
2007
34. Foley,S.C., Mogas,A.K., Olivenstein,R., Fiset,P.O., Chakir,J., Bourbeau,J., Ernst,P., Lemiere,C., Martin,J.G. and Hamid,Q.
    Increased expression of ADAM33 and ADAM8 with disease progression in asthma
    J Allergy Clin Immunol119, 863-871. PubMed  Europe PubMed DOI
35. Gomez-Gaviro,M., Dominguez-Luis,M., Canchado,J., Calafat,J., Janssen,H., Lara-Pezzi,E., Fourie,A., Tugores,A., Valenzuela-Fernandez,A., Mollinedo,F., Sanchez-Madrid,F. and Diaz-Gonzalez,F.
    Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding
    J Immunol178, 8053-8063. PubMed  Europe PubMed
36. Moss,M.L. and Rasmussen,F.H.
    Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening
    Anal Biochem366, 144-148. PubMed  Europe PubMed DOI  A  I
2006
37. Naus,S., Reipschlager,S., Wildeboer,D., Lichtenthaler,S.F., Mitterreiter,S., Guan,Z., Moss,M.L. and Bartsch,J.W.
    Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8
    Biol Chem387, 337-346. PubMed  Europe PubMed DOI  E
38. Wildeboer,D., Naus,S., Amy Sang,Q.X., Bartsch,J.W. and Pagenstecher,A.
    Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness
    J Neuropathol Exp Neurol65, 516-527. PubMed  Europe PubMed DOI
2005
39. Kelly,K., Hutchinson,G., Nebenius-Oosthuizen,D., Smith,A.J., Bartsch,J.W., Horiuchi,K., Rittger,A., Manova,K., Docherty,A.J. and Blobel,C.P.
    Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice
    Dev Dyn232, 221-231. PubMed  Europe PubMed DOI  K
2004
40. Ishikawa,N., Daigo,Y., Yasui,W., Inai,K., Nishimura,H., Tsuchiya,E., Kohno,N. and Nakamura,Y.
    ADAM8 as a novel serological and histochemical marker for lung cancer
    Clin Cancer Res10, 8363-8370. PubMed  Europe PubMed DOI
41. [YEAR:15-4-2004]King,N.E., Zimmermann,N., Pope,S.M., Fulkerson,P.C., Nikolaidis,N.M., Mishra,A., Witte,D.P. and Rothenberg,M.E.
    Expression and regulation of a disintegrin and metalloproteinase (ADAM)8 in experimental asthma
    Am J Respir Cell Mol Biol31, 257-265. PubMed  Europe PubMed DOI
42. [YEAR:16-4-2004]Naus,S., Richter,M., Wildeboer,D., Moss,M., Schachner,M. and Bartsch,J.W.
    Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death
    J Biol Chem279, 16083-16090. PubMed  Europe PubMed DOI  I
43. Wolfsberg,T.G. and White,J.M.
    ADAM metalloproteinases
    [ISSN:0-12-079610-4]2, 709-714.  V
2003
44. [YEAR:15-8-2003]Fourie,A.M., Coles,F., Moreno,V. and Karlsson,L.
    Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23
    J Biol Chem278, 30469-30477. PubMed  Europe PubMed DOI
2002
45. [YEAR:31-7-2002]Amour,A., Knight,C.G., English,W.R., Webster,A., Slocombe,P.M., Knauper,V., Docherty,A.J., Becherer,J.D., Blobel,C.P. and Murphy,G.
    The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs
    FEBS Lett524, 154-158. PubMed  Europe PubMed DOI
46. [YEAR:13-12-2002]Schlomann,U., Wildeboer,D., Webster,A., Antropova,O., Zeuschner,D., Knight,C.G., Docherty,A.J., Lambert,M., Skelton,L., Jockusch,H. and Bartsch,J.W.
    The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion
    J Biol Chem277, 48210-48219. PubMed  Europe PubMed DOI  I
2000
47. [YEAR:1-11-2000]Schlomann,U., Rathke-Hartlieb,S., Yamamoto,S., Jockusch,H. and Bartsch,J.W.
    Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): Implications for neuron-glia interactions during neurodegeneration
    J Neurosci20, 7964-7971. PubMed  Europe PubMed
1997
48. Kataoka,M., Yoshiyama,K., Matsuura,K., Hijiya,N., Higuchi,Y. and Yamamoto,S.
    Structure of the murine CD156 gene, characterization of its promoter, and chromosomal location
    J Biol Chem272, 18209-18215. PubMed  Europe PubMed DOI
49. Yoshiyama,K., Higuchi,Y., Kataoka,M., Matsuura,K. and Yamamoto,S.
    CD156 (human ADAM8): expression, primary amino acid sequence, and gene location
    Genomics41, 56-62. PubMed  Europe PubMed DOI