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Literature for peptidase M12.208: ADAM8 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ji,Z., Guo,J., Wang,M., Zhang,R., Dong,R., Sheng,Z., Zuo,P., Zhu,K., Li,Y., Yao,Y., He,H. and Ma,G.
    ADAM8 in macrophages exacerbates sepsis-induced cardiomyopathy by impeding efferocytosis
    Front Immunol (2025) 16, 1654688-1654688. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Shen,K., Shan,Z., Li,Y., Ji,Z., Zhou,L. and Lv,Z.
    TFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway
    J Biochem Mol Toxicol (2025) 39, e70097-e70097. PubMed  Europe PubMed DOI  K
    3. 2024
  3. Chen,K., Tao,H., Zhu,P., Chu,M., Li,X., Shi,Y., Zhang,L., Xu,Y., Lv,S., Huang,L., Huang,W. and Geng,D.
    ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis
    Arthritis Res Ther (2024) 26, 20-20. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Qian,Z., Zhang,Q., Li,P., Li,Y., Zhang,Y., Li,R., Zhao,T., Xia,M., Chen,Y. and Hong,X.
    A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway
    Mol Neurobiol (2024) 61, 3490-3502. PubMed  Europe PubMed DOI  K
    5. 2021
  5. Alawak,M., Abu Dayyih,A., Mahmoud,G., Tariq,I., Duse,L., Goergen,N., Engelhardt,K., Reddy Pinnapireddy,S., Jedelska,J., Awak,M., Konig,A.M., Brussler,J., Bartsch,J.W. and Bakowsky,U.
    ADAM 8 as a Novel Target for Doxorubicin Delivery to TNBC Cells using Magnetic Thermosensitive Liposomes
    Eur J Pharm Biopharm (2021) 158, 390-400. PubMed  Europe PubMed DOI
  6. Awan,T., Babendreyer,A., Mahmood Alvi,A., Dusterhoft,S., Lambertz,D., Bartsch,J.W., Liedtke,C. and Ludwig,A.
    Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells
    J Cell Mol Med (2021) 25, 1982-1999. PubMed  Europe PubMed DOI  K
  7. Awan,T., Babendreyer,A., Wozniak,J., Alvi,A.M., Sterzer,V., Cook,L., Bartsch,J.W., Liedtke,C., Yildiz,D. and Ludwig,A.
    Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver Inflammation Models and Enhances Cytokine Release In Vitro
    Mediators Inflamm (2021) 2021, 6665028-6665028. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Jaworek,C., Verel-Yilmaz,Y., Driesch,S., Ostgathe,S., Cook,L., Wagner,S., Bartsch,D.K., Slater,E.P. and Bartsch,J.W.
    Cohort Analysis of ADAM8 Expression in the PDAC Tumor Stroma
    J Pers Med (2021) 11, 113-113. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Lu,H., Meng,Y., Han,X. and Zhang,W.
    ADAM8 Activates NLRP3 Inflammasome to Promote Cerebral Ischemia-Reperfusion Injury
    J Healthc Eng (2021) 2021, 3097432-3097432. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2020
  10. Li,Y., Guo,S., Zhao,K., Conrad,C., Driescher,C., Rothbart,V., Schlomann,U., Guerreiro,H., Bopp,M.H., Konig,A., Carl,B., Pagenstecher,A., Nimsky,C. and Bartsch,J.W.
    ADAM8 affects glioblastoma progression by regulating osteopontin-mediated angiogenesis
    Biol Chem (2020) 402, 195-206. PubMed  Europe PubMed DOI
    11. 2019
  11. Schlomann,U., Dorzweiler,K., Nuti,E., Tuccinardi,T., Rossello,A. and Bartsch,J.W.
    Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays
    Biol Chem (2019) 400, 801-810. PubMed  Europe PubMed DOI  I
    12. 2018
  12. Polverino,F., Rojas-Quintero,J., Wang,X., Petersen,H., Zhang,L., Gai,X., Higham,A., Zhang,D., Gupta,K., Rout,A., Yambayev,I., Pinto-Plata,V., Sholl,L.M., Cunoosamy,D., Celli,B.R., Goldring,J., Singh,D., Tesfaigzi,Y., Wedzicha,J., Olsson,H. and Owen,C.A.
    A disintegrin and metalloproteinase domain-8: a novel protective proteinase in chronic obstructive pulmonary disease
    Am J Respir Crit Care Med (2018) 198, 1254-1267. PubMed  Europe PubMed DOI
    13. 2015
  13. Kleino,I., Jarviluoma,A., Hepojoki,J., Huovila,A.P. and Saksela,K.
    Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions
    PLoS ONE (2015) 10, e0121301-e0121301. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2012
  14. Bartsch,J.W. and Schlomann,U.
    ADAM8/MS2/CD156a
    [ISSN:978-0-12-407744-7] (2012) 3, 1094-1101. DOI
  15. Hall,T., Shieh,H.S., Day,J.E., Caspers,N., Chrencik,J.E., Williams,J.M., Pegg,L.E., Pauley,A.M., Moon,A.F., Krahn,J.M., Fischer,D.H., Kiefer,J.R., Tomasselli,A.G. and Zack,M.D.
    Structure of human ADAM-8 catalytic domain complexed with batimastat
    Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 68, 616-621. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  16. Liang,J. and Kong,Q.
    alpha-Cleavage of cellular prion protein
    Prion (2012) 6, 453-460. PubMed  Europe PubMed DOI
    17. 2011
  17. Dominguez-Luis,M., Lamana,A., Vazquez,J., Garcia-Navas,R., Mollinedo,F., Sanchez-Madrid,F., Diaz-Gonzalez,F. and Urzainqui,A.
    The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins
    Eur J Immunol (2011) 41, 3436-3442. PubMed  Europe PubMed DOI
  18. Ishizuka,H., Garcia-Palacios,V., Lu,G., Subler,M.A., Zhang,H., Boykin,C.S., Choi,S.J., Zhao,L., Patrene,K., Galson,D.L., Blair,H.C., Hadi,T.M., Windle,J.J., Kurihara,N. and Roodman,G.D.
    ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo
    J Bone Miner Res (2011) 26, 169-181. PubMed  Europe PubMed DOI
  19. Paulissen,G., Rocks,N., Gueders,M.M., Bedoret,D., Crahay,C., Quesada-Calvo,F., Hacha,J., Bekaert,S., Desmet,C., Foidart,J.M., Bureau,F., Noel,A. and Cataldo,D.D.
    ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation
    Eur J Immunol (2011) 41, 380-391. PubMed  Europe PubMed DOI
    20. 2010
  20. Bartsch,J.W., Wildeboer,D., Koller,G., Naus,S., Rittger,A., Moss,M.L., Minai,Y. and Jockusch,H.
    Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection
    J Neurosci (2010) 30, 12210-12218. PubMed  Europe PubMed DOI
  21. Gossens,K., Naus,S., Hollander,G.A. and Ziltener,H.J.
    Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity
    PLoS ONE (2010) 5, e12766-e12766. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Guaiquil,V.H., Swendeman,S., Zhou,W., Guaiquil,P., Weskamp,G., Bartsch,J.W. and Blobel,C.P.
    ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice
    J Mol Med (Berl) (2010) 88, 497-505. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Hernandez,I., Moreno,J.L., Zandueta,C., Montuenga,L. and Lecanda,F.
    Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer
    Oncogene (2010) 29, 3758-3769. PubMed  Europe PubMed DOI  M
  24. Iida,A., Sakaguchi,K., Sato,K., Sakurai,H., Nishimura,D., Iwaki,A., Takeuchi,M., Kobayashi,M., Misaki,K., Yonemura,S., Kawahara,A. and Sehara-Fujisawa,A.
    Metalloprotease-dependent onset of blood circulation in zebrafish
    Curr Biol (2010) 20, 1110-1116. PubMed  Europe PubMed DOI
  25. Naus,S., Blanchet,M.R., Gossens,K., Zaph,C., Bartsch,J.W., McNagny,K.M. and Ziltener,H.J.
    The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma
    Am J Respir Crit Care Med (2010) 181, 1318-1328. PubMed  Europe PubMed DOI  K  T
    26. 2009
  26. Ainola,M., Li,T.F., Mandelin,J., Hukkanen,M., Choi,S.J., Salo,J. and Konttinen,Y.T.
    Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction
    Ann Rheum Dis (2009) 68, 427-434. PubMed  Europe PubMed DOI
  27. Hall,T., Leone,J.W., Wiese,J.F., Griggs,D.W., Pegg,L.E., Pauley,A.M., Tomasselli,A.G. and Zack,M.D.
    Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity
    Biosci Rep (2009) 29, 217-228. PubMed  Europe PubMed DOI
  28. Hall,T., Pegg,L.E., Pauley,A.M., Fischer,H.D., Tomasselli,A.G. and Zack,M.D.
    ADAM8 substrate specificity: influence of pH on pre-processing and proteoglycan degradation
    Arch Biochem Biophys (2009) 491, 106-111. PubMed  Europe PubMed DOI
  29. Knolle,M.D. and Owen,C.A.
    ADAM8: a new therapeutic target for asthma
    Expert Opin Ther Targets (2009) 13, 523-540. PubMed  Europe PubMed DOI  V  T
  30. Koller,G., Schlomann,U., Golfi,P., Ferdous,T., Naus,S. and Bartsch,J.W.
    ADAM8/MS2/CD156, an emerging drug target in the treatment of inflammatory and invasive pathologies
    Curr Pharm Des (2009) 15, 2272-2281. PubMed  Europe PubMed DOI  T
  31. Mahoney,E.T., Benton,R.L., Maddie,M.A., Whittemore,S.R. and Hagg,T.
    ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice
    J Comp Neurol (2009) 512, 243-255. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Yeh,H.Y. and Klesius,P.H.
    Channel catfish (Ictalurus punctatus Rafinesque, 1818) CD156a (ADAM metallopeptidase domain 8): cDNA clone, characterization and expression in tissues
    Vet Immunol Immunopathol (2009) 132, 307-313. PubMed  Europe PubMed DOI  E
  33. Zack,M.D., Malfait,A.M., Skepner,A.P., Yates,M.P., Griggs,D.W., Hall,T., Hills,R.L., Alston,J.T., Nemirovskiy,O.V., Radabaugh,M.R., Leone,J.W., Arner,E.C. and Tortorella,M.D.
    ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271)
    Arthritis Rheum (2009) 60, 2704-2713. PubMed  Europe PubMed DOI  P
  34. Zack,M.D., Melton,M.A., Stock,J.L., Storer,C.E., Barve,R.A., Minnerly,J.C., Weiss,D.J., Stejskal,J.A., Tortorella,M.D., Turk,J.R., Shevlin,K.M. and Malfait,A.M.
    Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8)
    Clin Exp Immunol (2009) 158, 246-256. PubMed  Europe PubMed DOI  PMC  EPMC  K
    35. 2007
  35. Foley,S.C., Mogas,A.K., Olivenstein,R., Fiset,P.O., Chakir,J., Bourbeau,J., Ernst,P., Lemiere,C., Martin,J.G. and Hamid,Q.
    Increased expression of ADAM33 and ADAM8 with disease progression in asthma
    J Allergy Clin Immunol (2007) 119, 863-871. PubMed  Europe PubMed DOI
  36. Gomez-Gaviro,M., Dominguez-Luis,M., Canchado,J., Calafat,J., Janssen,H., Lara-Pezzi,E., Fourie,A., Tugores,A., Valenzuela-Fernandez,A., Mollinedo,F., Sanchez-Madrid,F. and Diaz-Gonzalez,F.
    Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding
    J Immunol (2007) 178, 8053-8063. PubMed  Europe PubMed
  37. Moss,M.L. and Rasmussen,F.H.
    Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening
    Anal Biochem (2007) 366, 144-148. PubMed  Europe PubMed DOI  A  I
    38. 2006
  38. Naus,S., Reipschlager,S., Wildeboer,D., Lichtenthaler,S.F., Mitterreiter,S., Guan,Z., Moss,M.L. and Bartsch,J.W.
    Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8
    Biol Chem (2006) 387, 337-346. PubMed  Europe PubMed DOI  E
  39. Wildeboer,D., Naus,S., Amy Sang,Q.X., Bartsch,J.W. and Pagenstecher,A.
    Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness
    J Neuropathol Exp Neurol (2006) 65, 516-527. PubMed  Europe PubMed DOI
    40. 2005
  40. Kelly,K., Hutchinson,G., Nebenius-Oosthuizen,D., Smith,A.J., Bartsch,J.W., Horiuchi,K., Rittger,A., Manova,K., Docherty,A.J. and Blobel,C.P.
    Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice
    Dev Dyn (2005) 232, 221-231. PubMed  Europe PubMed DOI  K
    41. 2004
  41. Ishikawa,N., Daigo,Y., Yasui,W., Inai,K., Nishimura,H., Tsuchiya,E., Kohno,N. and Nakamura,Y.
    ADAM8 as a novel serological and histochemical marker for lung cancer
    Clin Cancer Res (2004) 10, 8363-8370. PubMed  Europe PubMed DOI
  42. [YEAR:15-4-2004]King,N.E., Zimmermann,N., Pope,S.M., Fulkerson,P.C., Nikolaidis,N.M., Mishra,A., Witte,D.P. and Rothenberg,M.E.
    Expression and regulation of a disintegrin and metalloproteinase (ADAM)8 in experimental asthma
    Am J Respir Cell Mol Biol (15-4-2004) 31, 257-265. PubMed  Europe PubMed DOI
  43. [YEAR:16-4-2004]Naus,S., Richter,M., Wildeboer,D., Moss,M., Schachner,M. and Bartsch,J.W.
    Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death
    J Biol Chem (16-4-2004) 279, 16083-16090. PubMed  Europe PubMed DOI  I
  44. Wolfsberg,T.G. and White,J.M.
    ADAM metalloproteinases
    [ISSN:0-12-079610-4] (2004) 2, 709-714.  V
    45. 2003
  45. [YEAR:15-8-2003]Fourie,A.M., Coles,F., Moreno,V. and Karlsson,L.
    Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23
    J Biol Chem (15-8-2003) 278, 30469-30477. PubMed  Europe PubMed DOI
    46. 2002
  46. [YEAR:31-7-2002]Amour,A., Knight,C.G., English,W.R., Webster,A., Slocombe,P.M., Knauper,V., Docherty,A.J., Becherer,J.D., Blobel,C.P. and Murphy,G.
    The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs
    FEBS Lett (31-7-2002) 524, 154-158. PubMed  Europe PubMed DOI
  47. [YEAR:13-12-2002]Schlomann,U., Wildeboer,D., Webster,A., Antropova,O., Zeuschner,D., Knight,C.G., Docherty,A.J., Lambert,M., Skelton,L., Jockusch,H. and Bartsch,J.W.
    The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion
    J Biol Chem (13-12-2002) 277, 48210-48219. PubMed  Europe PubMed DOI  I
    48. 2000
  48. [YEAR:1-11-2000]Schlomann,U., Rathke-Hartlieb,S., Yamamoto,S., Jockusch,H. and Bartsch,J.W.
    Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): Implications for neuron-glia interactions during neurodegeneration
    J Neurosci (1-11-2000) 20, 7964-7971. PubMed  Europe PubMed
    49. 1997
  49. Kataoka,M., Yoshiyama,K., Matsuura,K., Hijiya,N., Higuchi,Y. and Yamamoto,S.
    Structure of the murine CD156 gene, characterization of its promoter, and chromosomal location
    J Biol Chem (1997) 272, 18209-18215. PubMed  Europe PubMed DOI
  50. Yoshiyama,K., Higuchi,Y., Kataoka,M., Matsuura,K. and Yamamoto,S.
    CD156 (human ADAM8): expression, primary amino acid sequence, and gene location
    Genomics (1997) 41, 56-62. PubMed  Europe PubMed DOI

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