$VAR1 = undef;

Summary for peptidase M12.208: ADAM8 peptidase

Names
MEROPS Name	ADAM8 peptidase
Other names	MS2, mCD158, CD156

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.208
Holotype	ADAM8 peptidase (Homo sapiens), Uniprot accession P78325 (peptidase unit: 196-400), MERNUM MER0003902
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (8 cleavages)
Activity status	human: active (Schlomann et al., 2002) mouse: putative
Knockout	Mice deficient in ADAM8 showed no distinct phenotype (Kelly et al., 2005).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/ADAM8
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/av/aql/apqvs/r/sl/sr (based on 29 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	0	0	1	2	2	0	0
Pro	5	3	0	4	0	0	1	3
Ala	2	11	9	14	1	3	3	0
Val	2	4	1	2	6	1	2	2
Leu	6	2	4	0	0	0	6	2
Ile	0	0	0	0	0	0	0	0
Met	0	0	1	0	0	0	0	0
Phe	1	0	1	2	2	0	1	0
Tyr	0	0	0	0	0	1	0	0
Trp	0	1	0	0	0	0	0	0
Ser	3	2	0	2	4	4	10	8
Thr	0	0	0	0	0	2	0	0
Cys	0	0	0	0	0	0	0	0
Asn	1	0	0	0	0	0	0	0
Gln	0	2	7	2	10	2	2	3
Asp	1	0	0	0	0	0	0	0
Glu	1	1	1	1	0	0	1	0
Lys	1	0	2	0	0	4	0	1
Arg	2	3	1	0	1	9	2	4
His	0	0	1	1	0	1	0	1