Literature for peptidase M10.004: matrix metallopeptidase-9

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Chien,Y.T., Liao,Y.H., Chong,X.W., Hsu,M.C., Chiu,C.H. and Huang,C.
The hemopexin domain of matrix metalloproteinase-9 attenuates lipopolysaccharide-induced interleukin-6 secretion in liver
Sci Rep (2025) PubMed Europe PubMed DOI
Conde-Tella,S.O., Gerlach,R.F. and Tanus-Santos,J.E.
Using Zymography to Assess Circulating Matrix Metalloproteinase (MMP)-2 and MMP-9 in Clinical Samples
Methods Mol Biol (2025) 2918, 177-186. PubMed Europe PubMed DOI L
George,J.
Zymography: A Simple and Powerful Tool for the Assessment of MMP-2 and MMP-9 in Pathological Conditions
Methods Mol Biol (2025) 2918, 187-199. PubMed Europe PubMed DOI L
Guo,P., Li,H., Zhang,X., Liu,Y., Xue,S., Yong,V.W. and Xue,M.
Matrix metalloproteinaseƒ_'9 in hemorrhagic transformation after acute ischemic stroke (Review)
Mol Med Rep (2025) 32 PubMed Europe PubMed DOI
Lin,X., Chen,Y., Zhong,B. and Yu,H.
Cathepsin K and glycosaminoglycans differentially regulate matrix metalloproteinase activity in dentin under various pH conditions
Int J Biol Macromol (2025) 327, 147486-147486. PubMed Europe PubMed DOI L
Veilleux,C., Roy,M.E. and Annabi,B.
Assessing MMP-2/9 Proteolytic Activity and Activation Status by Zymography in Preclinical and Clinical Tissue Samples
Methods Mol Biol (2025) 2918, 165-176. PubMed Europe PubMed DOI L
Vempati,R.K. and Malla,R.R.
Coralyne Targets the Catalytic Domain of MMP9: An In Silico and In Vitro Investigation
Crit Rev Oncog (2025) 30, 71-89. PubMed Europe PubMed DOI
Wang,Z., Chen,L., Zhang,H., Yan,Z., Liu,K., Qi,J., Lu,B., Yin,Y., Zhao,C., Niu,Y. and Li,W.
Mechanism of NUMBL Enhancing Axitinib Resistance in Clear Cell Renal Cell Carcinoma by UCHL1-Mediated Deubiquitination of MMP9
J Biol Chem (2025) , 110873-110873. PubMed Europe PubMed DOI

2024

Ansari,M.A., Mohd-Naim,N.F. and Ahmed,M.U.
Electrochemical Nanoaptasensor Based on Graphitic Carbon Nitride/Zirconium Dioxide/Multiwalled Carbon Nanotubes for Matrix Metalloproteinase-9 in Human Serum and Saliva
ACS Appl Bio Mater (2024) 7, 1579-1587. PubMed Europe PubMed DOI
Baidya,S.K., Banerjee,S., Ghosh,B., Jha,T. and Adhikari,N.
A fragment-based exploration of diverse MMP-9 inhibitors through classification-dependent structural assessment
J Mol Graph Model (2024) 126, 108671-108671. PubMed Europe PubMed DOI
Baltazar-Garcia,E.A., Vargas-Guerrero,B., Lima,A., Boavida Ferreira,R., Mendoza-Magana,M.L., Ramirez-Herrera,M.A., Baltazar-Diaz,T.A., Dominguez-Rosales,J.A., Salazar-Montes,A.M. and Gurrola-Diaz,C.M.
Deflamin Attenuated Lung Tissue Damage in an Ozone-Induced COPD Murine Model by Regulating MMP-9 Catalytic Activity
Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC L
Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E.
Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target
Basic Clin Pharmacol Toxicol (2024) 134, 727-736. PubMed Europe PubMed DOI L
Devoy,C., Flores Bueso,Y., Buckley,S., Walker,S. and Tangney,M.
Synthetic protein protease sensor platform
Front Bioeng Biotechnol (2024) 12, 1347953-1347953. PubMed Europe PubMed DOI PMC EPMC
Dibdiakova,K., Majercikova,Z., Galanda,T., Richterova,R., Kolarovszki,B., Racay,P. and Hatok,J.
Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors
Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Feng,Q., Liu,Q., Liu,Z., Xu,J., Yang,Y., Zhu,Y., Lu,G., Xu,G., Wu,D., Wang,F., Liu,B., Wang,W. and Ding,X.
USP9X inhibits metastasis in pulmonary sarcomatoid carcinoma by regulating epithelial-mesenchymal transition, angiogenesis and immune infiltration
Transl Oncol (2024) 47, 101950-101950. PubMed Europe PubMed DOI
Ganguly,K., Rejmak,E., Mikosz,M., Nikolaev,E., Knapska,E. and Kaczmarek,L.
Withdrawal: Matrix metalloproteinase (MMP) 9 transcription in mouse brain induced by fear learning
J Biol Chem (2024) 300, 105592-105592. PubMed Europe PubMed DOI PMC EPMC
Golombek,S., Doll,I., Kaufmann,L., Lescan,M., Schlensak,C. and Avci-Adali,M.
A Novel Strategy for the Treatment of Aneurysms: Inhibition of MMP-9 Activity through the Delivery of TIMP-1 Encoding Synthetic mRNA into Arteries
Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC L
Huang,Q., Song,Y., Lei,X., Huang,H. and Nong,W.
MMP-9 as a clinical marker for endometriosis: a meta-analysis and bioinformatics analysis
Front Endocrinol (Lausanne) (2024) 15, 1475531-1475531. PubMed Europe PubMed DOI PMC EPMC V
Kaczmarek,K.T., Protokowicz,K. and Kaczmarek,L.
Matrix metalloproteinase-9: A magic drug target in neuropsychiatry?
J Neurochem (2024) 168, 1842-1853. PubMed Europe PubMed DOI
Kim,J.H., Shivkumar,A., Norimoto,M., Castro Lingl,S., Seitz,C., Amaro,R.E., Gonias,S.L., Yang,J. and Campana,W.M.
Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9
Biochemistry (2024) 63, 725-732. PubMed Europe PubMed DOI
La Russa,A., Serra,R., Faga,T., Crugliano,G., Bonelli,A., Coppolino,G., Bolignano,D., Battaglia,Y., Ielapi,N., Costa,D., Michael,A. and Andreucci,M.
Kidney Fibrosis and Matrix Metalloproteinases (MMPs)
Front Biosci (Landmark Ed) (2024) 29, 192-192. PubMed Europe PubMed DOI V
Lee,C.J., Jang,T.Y., Jeon,S.E., Yun,H.J., Cho,Y.H., Lim,D.Y. and Nam,J.S.
The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression
Nat Commun (2024) 15, 10422-10422. PubMed Europe PubMed DOI PMC EPMC
MacPherson,D.S., Dave,D., Kassem,S., Doganata,S., Zeglis,B.M. and Ulijn,R.V.
Tuning Supramolecular Chirality in Iodinated Amphiphilic Peptides Through Tripeptide Linker Editing
Biomacromolecules (2024) 25, 2277-2285. PubMed Europe PubMed DOI
Mastalier Manolescu,B.S., Lazar,A.M., Tiplica,G.S., Zurac,S.A., Rebosapca,A., Andreescu,B. and Popp,C.G.
MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination
Rom J Morphol Embryol (2024) 65, 45-52. PubMed Europe PubMed DOI
Rodrigues,K.E., Pontes,M.H.B., Cantao,M.B.S. and Prado,A.F.
The role of matrix metalloproteinase-9 in cardiac remodeling and dysfunction and as a possible blood biomarker in heart failure
Pharmacol Res (2024) 206, 107285-107285. PubMed Europe PubMed DOI V
Rotenberg,N., Feldman,M., Shirian,J., Hockla,A., Radisky,E.S. and Shifman,J.M.
Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple negative breast cancer cells
J Biol Chem (2024) , 107867-107867. PubMed Europe PubMed DOI
Wang,Q., Lin,Z., Yao,C., Liu,J., Chen,J. and Diao,L.
Meta-analysis of MMP-9 levels in the serum of patients with epilepsy
Front Neurosci (2024) 18, 1296876-1296876. PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Jiao,L., Qiang,C., Chen,C., Shen,Z., Ding,F., Lv,L., Zhu,T., Lu,Y. and Cui,X.
The role of matrix metalloproteinase 9 in fibrosis diseases and its molecular mechanisms
Biomed Pharmacother (2024) 171, 116116-116116. PubMed Europe PubMed DOI V
Zhou,J., Le,C.Q., Zhang,Y. and Wells,J.A.
A general approach for selection of epitope-directed binders to proteins
Proc Natl Acad Sci U S A (2024) 121, e2317307121-e2317307121. PubMed Europe PubMed DOI PMC EPMC
Zhou,L., Bai,G., Song,Y., Liu,X., Li,X., Deng,Y., Si,Y., Shi,Y. and Li,H.
AGEs induce MMP-9 promoter demethylation through the GADD45alpha-mediated BER pathway to promote breast cancer metastasis in patients with diabetes
Endocr Relat Cancer (2024) PubMed Europe PubMed DOI

2023

Bakiri,L.
Open Thy Lattice Osteoclast, Resorb me!
J Cell Biol (2023) 222 PubMed Europe PubMed DOI PMC EPMC
Bonadio,A., Oguche,S., Lavy,T., Kleifeld,O. and Shifman,J.
Computational design of matrix metalloprotenaise-9 (MMP-9) resistant to auto-cleavage
Biochem J (2023) 480, 1097-1107. PubMed Europe PubMed DOI PMC EPMC
Camargo,J.A., Viana,N.I., Pimenta,R., Guimaraes,V.R., Dos Santos,G.A., Candido,P., Ghazarian,V., Romao,P., Silva,I.A., Birbrair,A., Srougi,M., Nahas,W.C., Leite,K.R., Trarbach,E.B. and Reis,S.T.
The Effect of Gene Editing by CRISPR-Cas9 of miR-21 and the Indirect Target MMP9 in Metastatic Prostate Cancer
Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Coates-Park,S., Lazaroff,C., Gurung,S., Rich,J., Colladay,A., O'Neill,M., Butler,G.S., Overall,C.M., Stetler-Stevenson,W.G. and Peeney,D.
Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9
Matrix Biol (2023) 123, 59-70. PubMed Europe PubMed DOI
Dimic-Janjic,S., Hoda,M.A., Milenkovic,B., Kotur-Stevuljevic,J., Stjepanovic,M., Gompelmann,D., Jankovic,J., Miljkovic,M., Milin-Lazovic,J., Djurdjevic,N., Maric,D., Milivojevic,I. and Popevic,S.
The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
Eur J Med Res (2023) 28, 127-127. PubMed Europe PubMed DOI PMC EPMC
Faisal,T.R., Adouni,M. and Dhaher,Y.Y.
Surrogate modeling of articular cartilage degradation to understand the synergistic role of MMP-1 and MMP-9: a case study
Biomech Model Mechanobiol (2023) 22, 43-56. PubMed Europe PubMed DOI
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
Res Sq (2023) PubMed Europe PubMed DOI PMC EPMC
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
Sci Rep (2023) 13, 5186-5186. PubMed Europe PubMed DOI PMC EPMC
Houchen,C.J., Castro,B., Hahn Leat,P., Mohammad,N., Hall-Glenn,F. and Bumann,E.E.
Treatment with an inhibitor of matrix metalloproteinase 9 or cathepsin K lengthens embryonic lower jaw bone
Orthod Craniofac Res (2023) PubMed Europe PubMed DOI
Kalali,D.
The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review
Glob Med Genet (2023) 10, 48-53. PubMed Europe PubMed DOI PMC EPMC
Kowalczyk,A., Nisiewicz,M.K., Bamburowicz-Klimkowska,M., Kasprzak,A., Ruzycka-Ayoush,M., Koszytkowska-Stawinska,M. and Nowicka,A.M.
Effective voltammetric tool for simultaneous detection of MMP-1, MMP-2, and MMP-9; important non-small cell lung cancer biomarkers
Biosens Bioelectron (2023) 229, 115212-115212. PubMed Europe PubMed DOI
Miao,M., Lyu,M., Zhong,C. and Liu,Y.
Correlation Between MMP9 Promoter Methylation and Transient Ischemic Attack/Mild Ischemic Stroke with Early Cognitive Impairment
Clin Interv Aging (2023) 18, 1221-1232. PubMed Europe PubMed DOI PMC EPMC
Pawar,N.R., Buzza,M.S., Duru,N., Strong,A.A. and Antalis,T.M.
Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis
J Cell Biol (2023) 222 PubMed Europe PubMed DOI PMC EPMC
Rashid,Z.A. and Bardaweel,S.K.
Novel Matrix Metalloproteinase-9 (MMP-9) Inhibitors in Cancer Treatment
Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Wan,X.C., Zhang,H., Shen,Y., Zhou,S.Y., Yang,P., Zhou,X.J., Gu,H., Le,Q.H., Xu,J.J., Zhou,X.T. and Hong,J.X.
[A preliminary study on the tear matrix metalloproteinase 9 point-of-care assay using a domestic kit]
Zhonghua Yan Ke Za Zhi (2023) 59, 272-278. PubMed Europe PubMed DOI
We,F., Cui,Y., Guo,X., Dong,G. and Li,X.
Correlations of inflammatory factors, CCCK-18, MMP-9 and D-Dimer with APACHE II score and prognosis of patients with acute cerebral hemorrhage
Minerva Med (2023) 114, 162-168. PubMed Europe PubMed DOI
Xiao,X., Miao,X., Duan,S., Liu,S., Cao,Q., Wu,R., Tao,C., Zhao,J., Qu,Q., Markiewicz,A., Peng,R., Chen,Y., Zaczek,A. and Liu,J.
Single-Cell Enzymatic Screening for Epithelial Mesenchymal Transition with an Ultrasensitive Superwetting Droplet-Array Microchip
Small Methods (2023) 7, e2300096-e2300096. PubMed Europe PubMed DOI
Yang,R.Q., Chen,Y.L., Sun,L.C., Ou,W., Liu,H.Y., Zhang,L.J., Liu,G.M., Zhao,G. and Cao,M.J.
Involvement of MMP-9 in collagen degradation of sea bass (Lateolabrax japonicus): Cloning, expression, and characterization
J Food Sci (2023) 88, 638-649. PubMed Europe PubMed DOI
Zeng,Y., Qian,M., Yang,X., Gao,Q., Zhang,C. and Qi,H.
Electrochemiluminescence bioassay with anti-fouling ability for determination of matrix metalloproteinase 9 secreted from living cells under external stimulation
Mikrochim Acta (2023) 190, 422-422. PubMed Europe PubMed DOI
Zhang,J., Xu,L., Zhang,J., Liu,Y., Li,X., Ren,T. and Liu,H.
Pan-cancer analysis of the prognostic and immunological role of matrix metalloproteinase 9
Medicine (Baltimore) (2023) 102, e34499-e34499. PubMed Europe PubMed DOI PMC EPMC

2022

Basia,D., Gupta,M.D., Kunal,S., Muheeb,G., Girish,M.P., Bansal,A., Batra,V., Yusuf,J., Mukhopadhyay,S., Tyagi,S. and Singh,R.
Matrix metalloproteinases and their gene polymorphism in young ST-segment elevation myocardial infarction
Indian Heart J (2022) 74, 519-523. PubMed Europe PubMed DOI PMC EPMC
Fan,D., Zheng,C., Wu,W., Chen,Y., Chen,D., Hu,X., Shen,C., Chen,M., Li,R. and Chen,Y.
MMP9 SNP and MMP SNP-SNP interactions increase the risk for ischemic stroke in the Han Hakka population
Brain Behav (2022) 12, e2473-e2473. PubMed Europe PubMed DOI
Gomez-Alonso,I.S., Martinez-Garcia,S., Betanzos-Cabrera,G., Juarez,E., Sarabia-Leon,M.C., Herrera,M.T., Gomez-Chavez,F., Sanchez-Torres,L., Rodriguez-Martinez,S., Cancino-Diaz,M.E., Cancino,J. and Cancino-Diaz,J.C.
Low Concentration of the Neutrophil Proteases Cathepsin G, Cathepsin B, Proteinase-3 and Metalloproteinase-9 Induce Biofilm Formation in Non-Biofilm-Forming Staphylococcus epidermidis Isolates
Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Laroui,A., Galarneau,L., Abolghasemi,A., Benachenhou,S., Plantefeve,R., Bouchouirab,F.Z., Lepage,J.F., Corbin,F. and Caku,A.
Clinical significance of matrix metalloproteinase-9 in Fragile X Syndrome
Sci Rep (2022) 12, 15386-15386. PubMed Europe PubMed DOI PMC EPMC L
Li,H., Sheng,Z., Khan,S., Zhang,R., Liu,Y., Zhang,Y., Yong,V.W. and Xue,M.
Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression
Front Neurol (2022) 13, 861843-861843. PubMed Europe PubMed DOI PMC EPMC V
Li,X., Zha,L., Li,B., Sun,R., Liu,J. and Zeng,H.
Clinical significance of MMP-9 overexpression in endometrial cancer: A PRISMA-compliant meta-analysis
Front Oncol (2022) 12, 925424-925424. PubMed Europe PubMed DOI PMC EPMC V
MacPherson,D.S., McPhee,S.A., Zeglis,B.M. and Ulijn,R.V.
The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences
ACS Biomater Sci Eng (2022) 8, 579-587. PubMed Europe PubMed DOI
Min,H.K., Kim,S.H., Lee,J.Y., Lee,S.H. and Kim,H.R.
DJ-1 controls T cell differentiation and osteoclastogenesis in rheumatoid arthritis
Sci Rep (2022) 12, 12767-12767. PubMed Europe PubMed DOI PMC EPMC
Morales-Hernandez,F.V., Bautista-Bautista,G., Acuna-Gonzalez,R.J., Vazquez-Cardenas,P., Lopez-Canales,J.S., Lozano-Cuenca,J., Osorio-Caballero,M. and Flores-Herrera,H.
Differential proMMP-2 and proMMP-9 secretion in human pre-implantation embryos at day 5 of development
Acta Biochim Pol (2022) 69, 683-689. PubMed Europe PubMed DOI L
Pan,L., Cao,Z., Chen,L., Qian,M. and Yan,Y.
Association of BDNF and MMP-9 single-nucleotide polymorphisms with the clinical phenotype of schizophrenia
Front Psychiatry (2022) 13, 941973-941973. PubMed Europe PubMed DOI PMC EPMC
Snipas,S.J., Jappelli,R., Torkamani,A., Paternostro,G. and Salvesen,G.S.
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel-Lindau syndrome
Biochem J (2022) 479, 1533-1542. PubMed Europe PubMed DOI
Takai,S. and Jin,D.
Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9
Biomedicines (2022) 10 PubMed Europe PubMed DOI PMC EPMC V
Tian,K., Du,G., Wang,X., Wu,X., Li,L., Liu,W. and Wu,R.
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway
Mol Biol Rep (2022) PubMed Europe PubMed DOI
Wu,Y., Lu,S., Huang,X., Liu,Y., Huang,K., Liu,Z., Xu,W., Zhu,W., Hou,J., Liu,H. and Zhang,X.
Targeting cIAPs attenuates CCl4-induced liver fibrosis by increasing MMP9 expression derived from neutrophils
Life Sci (2022) 289, 120235-120235. PubMed Europe PubMed DOI
Yun,H.S., Kim,J.P., Kim,E.J., Kim,B.G. and Jeong,H.J.
A rapid ELISA for the detection of matrix metallopeptidase 9 using a recombinant Fab-type antibody
Biochem Biophys Res Commun (2022) 636, 184-189. PubMed Europe PubMed DOI
Zhu,G., Chen,W., Tang,C.Y., McVicar,A., Edwards,D., Wang,J., McConnell,M., Yang,S., Li,Y., Chang,Z. and Li,Y.P.
Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis
Int J Biol Sci (2022) 18, 5522-5538. PubMed Europe PubMed DOI PMC EPMC

2021

Al-Sadi,R., Engers,J., Haque,M., King,S., Al-Omari,D. and Ma,T.Y.
Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-kappaB activation
PLoS ONE (2021) 16, e0249544-e0249544. PubMed Europe PubMed DOI PMC EPMC K
Anuar,N.N.M., Zulkafali,N.I.N. and Ugusman,A.
Modulation of Matrix Metalloproteinases by Plant-Derived Products
Curr Cancer Drug Targets (2021) 21, 91-106. PubMed Europe PubMed DOI V I
Bassiouni,W., Ali,M.A.M. and Schulz,R.
Multifunctional intracellular matrix metalloproteinases: implications in disease
FEBS J (2021) 288, 7162-7182. PubMed Europe PubMed DOI V
Buttacavoli,M., Di Cara,G., Roz,E., Pucci-Minafra,I., Feo,S. and Cancemi,P.
Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9
Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC L
Denner,D.R., Udan-Johns,M.L. and Nichols,M.R.
Inhibition of matrix metalloproteinase-9 secretion by dimethyl sulfoxide and cyclic adenosine monophosphate in human monocytes
World J Biol Chem (2021) 12, 1-14. PubMed Europe PubMed DOI PMC EPMC
Dusanovic Pjevic,M., Jekic,B., Beslac Bumbasirevic,L., Vojvodic,L., Damnjanovic,T., Grk,M., Maksimovic,N., Pesic,M., Gulic,M., Trickovic,J. and Kacar,K.
TT genotype of the MMP-9-1562C/T polymorphism may be a risk factor for thrombolytic therapy-induced hemorrhagic complications after acute ischemic stroke
Pharmacotherapy (2021) PubMed Europe PubMed DOI
Elhewala,A.A., Sanad,M., Soliman,A.M., Sami,M.M. and Ahmed,A.A.
Matrix metalloproteinase-9 in pediatric rheumatic heart disease with and without heart failure
Biomed Rep (2021) 14, 4-4. PubMed Europe PubMed DOI PMC EPMC
Goossens,J.F., Goossens,L. and Bailly,C.
Hinokiflavone and Related C-O-C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action
Nat Prod Bioprospect (2021) PubMed Europe PubMed DOI PMC EPMC V I
Jeong,H.J., Kim,E.J., Kim,J.K., Kim,Y.G., Lee,C.S., Ko,B.J. and Kim,B.G.
Expression of soluble recombinant human matrix metalloproteinase 9 and generation of its monoclonal antibody
Protein Expr Purif (2021) 187, 105931-105931. PubMed Europe PubMed DOI
Lenci,E., Angeli,A., Calugi,L., Innocenti,R., Carta,F., Supuran,C.T. and Trabocchi,A.
Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II
Eur J Med Chem (2021) 214, 113260-113260. PubMed Europe PubMed DOI
Nisiewicz,M.K., Kowalczyk,A., Gajda,A., Kasprzak,A., Bamburowicz-Klimkowska,M., Grudzinski,I.P. and Nowicka,A.M.
Enzymatic cleavage of specific dipeptide conjugated with ferrocene as a flexible ultra-sensitive and fast voltammetric assay of matrix metalloproteinase-9 considered a prognostic cancer biomarker in plasma samples
Biosens Bioelectron (2021) 195, 113653-113653. PubMed Europe PubMed DOI A
Nissi,R., Santala,M. and Talvensaari-Mattila,A.
The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study
BMC Res Notes (2021) 14, 31-31. PubMed Europe PubMed DOI PMC EPMC
Rocchi,D., Blazquez-Barbadillo,C., Agamennone,M., Laghezza,A., Tortorella,P., Vicente-Zurdo,D., Rosales-Conrado,N., Moyano,P., Pino,J.D., Gonzalez,J.F. and Menendez,J.C.
Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity
Eur J Med Chem (2021) 210, 113061-113061. PubMed Europe PubMed DOI I
Schoretsanitis,G., de Filippis,R., Ntogka,M., Leucht,S., Correll,C.U. and Kane,J.M.
Matrix Metalloproteinase 9 Blood Alterations in Patients With Schizophrenia Spectrum Disorders: A Systematic Review and Meta-Analysis
Schizophr Bull (2021) PubMed Europe PubMed DOI V
Sharma,R., Kumar,V., Logani,A., Chawla,A., Mir,R.A., Sharma,S. and Kalaivani,M.
Association between concentration of active MMP-9 in pulpal blood and pulpotomy outcome in permanent mature teeth with irreversible pulpitis - A preliminary study
Int Endod J (2021) 54, 479-489. PubMed Europe PubMed DOI
Shoari,A., Kanavi,M.R. and Rasaee,M.J.
Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome; a review study
Exp Eye Res (2021) 205, 108523-108523. PubMed Europe PubMed DOI
Starikova,D., Ponomarenko,I., Reshetnikov,E., Dvornyk,V. and Churnosov,M.
Novel data about association of the functionally significant polymorphisms of the MMP-9 gene with exfoliation glaucoma in the Caucasian population of Central Russia
Ophthalmic Res (2021) 64, 458-464. PubMed Europe PubMed DOI
Testa,G., Staurenghi,E., Giannelli,S., Sottero,B., Gargiulo,S., Poli,G., Gamba,P. and Leonarduzzi,G.
Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis
Biochimie (2021) 181, 191-203. PubMed Europe PubMed DOI I
Tsegaye,S., Mehdi,M., Labisso,W.L. and Melka,D.S.
Cysteine Cathepsins and Matrix Metalloproteases Among Breast Cancer Patients
Breast Cancer (Dove Med Press) (2021) 13, 271-283. PubMed Europe PubMed DOI PMC EPMC L
Vashum,Y., Premsingh,R., Kottaiswamy,A., Soma,M., Padmanaban,A., Kalaiselvan,P. and Samuel,S.
Inhibitory effect of cathepsin K inhibitor (ODN-MK-0822) on invasion, migration and adhesion of human breast cancer cells in vitro
Mol Biol Rep (2021) 48, 105-116. PubMed Europe PubMed DOI I
Yamahana,H., Terashima,M., Takatsuka,R., Asada,C., Suzuki,T., Uto,Y. and Takino,T.
Erratum: TGF-beta1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells (BBREP_101072)
Biochem Biophys Rep (2021) 27, 101093-101093. PubMed Europe PubMed DOI PMC EPMC
Yigit,D., Taskinlar,H. and Avlan,D.
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Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling
Int Immunopharmacol (2020) 90, 107234-107234. PubMed Europe PubMed DOI
Slovacek,H., Khanna,R., Poredos,P., Jezovnik,M., Hoppensteadt,D., Fareed,J. and Hopkinson,W.
Interrelationship of Osteopontin, MMP-9 and ADAMTS4 in Patients With Osteoarthritis Undergoing Total Joint Arthroplasty
Clin Appl Thromb Hemost (2020) 26, 1076029620964864-1076029620964864. PubMed Europe PubMed DOI PMC EPMC
Tang,Z., Wang,W., Liu,Z., Sun,X., Liao,Z., Chen,F., Jiang,G. and Huo,G.
[Blocking ERK signaling pathway lowers MMP-9 expression to alleviate brain edema after traumatic brain injury in rats]
Zhejiang Da Xue Xue Bao Yi Xue Ban (2020) 40, 1018-1022. PubMed Europe PubMed
Tsai,C.B., Hsia,N.Y., Wang,Z.H., Yang,J.S., Hsu,Y.M., Wang,Y.C., Chang,W.S., Bau,D.T., Yin,M.C. and Tsai,C.W.
The Contribution of MMP-9 Genotypes to Pterygium in Taiwan
Anticancer Res (2020) 40, 4523-4527. PubMed Europe PubMed DOI
Ueland,T., Holter,J.C., Holten,A.R., Muller,K.E., Lind,A., Bekken,G.K., Dudman,S., Aukrust,P., Dyrhol-Riise,A.M. and Heggelund,L.
Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure
J Infect (2020) 81, e41-e41. PubMed Europe PubMed DOI PMC EPMC
Uzun Cicek,A., Mercan Isik,C., Bakir,S., Ulger,D., Sari,S.A., Bakir,D. and Cam,S.
Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD)
J Neural Transm (Vienna) (2020) 127, 1409-1418. PubMed Europe PubMed DOI
Vira,H.J., Pradhan,V.D., Umare,V.D., Chaudhary,A.K., Rajadhyksha,A.G., Nadkar,M.Y., Ghosh,K. and Nadkarni,A.H.
Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients
Neth J Med (2020) 78, 261-268. PubMed Europe PubMed
Wang,S., Jiao,J., Dong,X. and Yang,F.
Effect of total knee replacement combined with Yunnan Baiyao on the expression of serum IL-6, TNF-alpha, VCAM-1 and MMP-9 in patients with knee osteoarthritis
Panminerva Med (2020) PubMed Europe PubMed DOI
Wang,Z.C., Li,Y., Wang,K.L., Wang,L., You,B.S., Zhao,D.F., Liu,Z.Q., Fang,R.Z., Wang,J.Q., Zhang,W., Zhang,J.M. and Xu,W.H.
miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling
Aging (Albany NY) (2020) 12, 14418-14433. PubMed Europe PubMed DOI K
Wu,W.C., Lee,W.J., Lee,T.H., Chen,S.C. and Chen,C.Y.
Do different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2, -7, and -9 among patients with type 2 diabetes mellitus?
World J Diabetes (2020) 11, 252-260. PubMed Europe PubMed DOI PMC EPMC
Xu,T., Zhang,S., Qiu,D., Li,X. and Fan,Y.
Association between matrix metalloproteinase 9 polymorphisms and breast cancer risk: An updated meta-analysis and trial sequential analysis
Gene (2020) 759, 144972-144972. PubMed Europe PubMed DOI
Xuan,L., Han,F., Gong,L., Lv,Y., Wan,Z., Liu,H., Ren,L., Yang,S., Zhang,W., Li,T., Tan,C. and Liu,L.
Ceramide induces MMP-9 expression through JAK2/STAT3 pathway in airway epithelium
Lipids Health Dis (2020) 19, 196-196. PubMed Europe PubMed DOI PMC EPMC
Yang,B., Zhang,D., Qian,J. and Cheng,Y.
Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system
Mol Cell Biochem (2020) 474, 199-208. PubMed Europe PubMed DOI
Yang,C.C., Hsiao,L.D., Tseng,H.C., Kuo,C.M. and Yang,C.M.
Pristimerin Inhibits MMP-9 Expression and Cell Migration Through Attenuating NOX/ROS-Dependent NF-kappaB Activation in Rat Brain Astrocytes Challenged with LPS
J Inflamm Res (2020) 13, 325-341. PubMed Europe PubMed DOI PMC EPMC
Yuan,J., Zhang,G., Li,X., Ma,Q., Cheng,W., Wang,W., Zhang,B., Hu,T. and Song,G.
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway
Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC K
Yue,Y., Hsiao,Y.W. and Zhou,J.B.
Association between MMP/TIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients
Biomed Res Int (2020) 2020, 2961742-2961742. PubMed Europe PubMed DOI PMC EPMC
Zhang,H., Huang,W., Liu,H., Zheng,Y. and Liao,L.
Mechanical stretching of pulmonary vein stimulates matrix metalloproteinase-9 and transforming growth factor-beta1 through stretch-activated channel/MAPK pathways in pulmonary hypertension due to left heart disease model rats
PLoS ONE (2020) 15, e0235824-e0235824. PubMed Europe PubMed DOI PMC EPMC
Zhang,L., Cui,Y., Yang,Y., Wei,J., Liu,W., Cai,L., Wang,L., Zhang,D., Xie,J. and Cheng,L.
The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells
Arch Oral Biol (2020) 122, 104991-104991. PubMed Europe PubMed DOI L
Zhang,N., Liu,C., Jin,L., Zhang,R., Wang,T., Wang,Q., Chen,J., Yang,F., Siebert,H.C. and Zheng,X.
Ketogenic Diet Elicits Antitumor Properties through Inducing Oxidative Stress, Inhibiting MMP-9 Expression, and Rebalancing M1/M2 Tumor-Associated Macrophage Phenotype in a Mouse Model of Colon Cancer
J Agric Food Chem (2020) 68, 11182-11196. PubMed Europe PubMed DOI
Zhang,Y., Liu,H., Chen,Z., Yu,M., Li,J., Dong,H., Li,N., Ding,X., Ge,Y., Liu,C., Ma,T. and Gui,B.
TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice
Neurochem Int (2020) 140, 104818-104818. PubMed Europe PubMed DOI
Zhao,H.M., Jin,L., Liu,Y. and Hong,X.
Changes in expressions of miR-22-3p and MMP-9 in rats with thoracic aortic aneurysm and their significance
Eur Rev Med Pharmacol Sci (2020) 24, 6949-6954. PubMed Europe PubMed DOI
Zhao,L., Song,C., Huang,Y., Lei,W. and Sun,J.
MMP-9 regulates CX3CL1/CX3CR1 in the early phase of neuropathic pain in chronic sciatic nerve constriction injury (CCI) rats
Ann Palliat Med (2020) 9, 2020-2027. PubMed Europe PubMed DOI K
Zhao,R., Zhou,H. and Zhu,J.
MMP-9-C1562T polymorphism and susceptibility to chronic obstructive pulmonary disease: A meta-analysis
Medicine (Baltimore) (2020) 99, e21479-e21479. PubMed Europe PubMed DOI PMC EPMC
Zheng,K., Li,Q., Lin,D., Zong,X., Luo,X., Yang,M., Yue,X. and Ma,S.
Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites
Food Funct (2020) 11, 7481-7494. PubMed Europe PubMed DOI
Zoumboulakis,D., Cirella,K.R., Gougeon,P.Y., Lourenssen,S.R. and Blennerhassett,M.G.
MMP-9 Processing of Intestinal Smooth Muscle-derived GDNF is Required for Neurotrophic Action on Enteric Neurons
Neuroscience (2020) 443, 8-18. PubMed Europe PubMed DOI

2019

Abu Bakar,A.R., Ripen,A.M., Merican,A.F. and Mohamad,S.B.
Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
Nat Prod Res (2019) 33, 1765-1768. PubMed Europe PubMed DOI I
Ayoup,M.S., Fouad,M.A., Abdel-Hamid,H., Ramadan,E.S., Abu-Serie,M.M., Noby,A. and Teleb,M.
Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis
Eur J Med Chem (2019) , 111875-111875. PubMed Europe PubMed DOI I
Bertran,A., Khomiak,D., Konopka,A., Rejmak,E., Bulska,E., Seco,J., Kaczmarek,L., Tarrago,T. and Prades,R.
Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors
Bioorg Chem (2019) , 103365-103365. PubMed Europe PubMed DOI I
Cancemi,P., Di Falco,F., Feo,S., Arizza,V. and Vizzini,A.
The gelatinase MMP-9like is involved in regulation of LPS inflammatory response in Ciona robusta
Fish Shellfish Immunol (2019) 86, 213-222. PubMed Europe PubMed DOI
Hannocks,M.J., Zhang,X., Gerwien,H., Chashchina,A., Burmeister,M., Korpos,E., Song,J. and Sorokin,L.
The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes
Matrix Biol (2019) 75-76, 102-113. PubMed Europe PubMed DOI
Ianni,A., Celenza,G. and Franceschini,N.
Oxaprozin: a new hope in the modulation of matrix metalloproteinase 9 activity
Chem Biol Drug Des (2019) 93, 811-817. PubMed Europe PubMed DOI I
Lyu,Y., Xiao,Q., Yin,L., Yang,L. and He,W.
Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis
Signal Transduct Target Ther (2019) 4, 26-26. PubMed Europe PubMed DOI I
Wang,X., Maretti-Mira,A.C., Wang,L. and DeLeve,L.D.
Liver-selective mmp-9 inhibition in the rat eliminates ischemia-reperfusion injury and accelerates liver regeneration
Hepatology (2019) 69, 314-328. PubMed Europe PubMed DOI

2018

Beutel,B., Song,J., Konken,C.P., Korpos,E., Schinor,B., Gerwien,H., Vidyadharan,R., Burmeister,M., Li,L., Haufe,G. and Sorokin,L.
New in vivo compatible matrix metalloproteinase (MMP)-2 and MMP-9 inhibitors
Bioconjug Chem (2018) 29, 3715-3725. PubMed Europe PubMed DOI I
Cao,S., Li,Z., Zhao,J., Chen,M. and Ma,N.
Rational engineering a multichannel upconversion sensor for multiplex detection of matrix metalloproteinase activities
ACS Sens (2018) 3, 1522-1530. PubMed Europe PubMed DOI L
Eshwar,A.K., Wolfrum,N., Stephan,R., Fanning,S. and Lehner,A.
Interaction of matrix metalloprotease-9 and Zpx in Cronobacter turicensis LMG 23827(T) mediated infections in the zebrafish model
Cell Microbiol (2018) , e12888-e12888. PubMed Europe PubMed DOI
Gautam,J., Banskota,S., Lee,H., Lee,Y.J., Jeon,Y.H., Kim,J.A. and Jeong,B.S.
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis
Exp Mol Med (2018) 50, 118-118. PubMed Europe PubMed DOI
Khomiak,D. and Kaczmarek,L.
Matrix metalloproteinase 9 and epileptogenesis - the crucial role of the enzyme and strategies to prevent the disease development
Postepy Biochem (2018) 64, 222-230. PubMed Europe PubMed DOI
Li,X.
Gelatinase inhibitors: a patent review (2011-2017)
Expert Opin Ther Pat (2018) 28, 31-46. PubMed Europe PubMed DOI V I
Li,Y., Chen,L., Yao,S., Chen,J., Hu,W., Wang,M., Chen,S., Chen,X., Li,S., Gu,X., Ma,G., Zhao,B., Zhong,W. and Li,K.
Association of polymorphisms of the matrix metalloproteinase 9 gene with ischaemic stroke in a Southern Chinese population
Cell Physiol Biochem (2018) 49, 2188-2199. PubMed Europe PubMed DOI M
Liu,J.W. and Chen,D.Q.
Correlations of MMP-2 and MMP-9 gene polymorphisms with the risk of hepatopulmonary syndrome in cirrhotic patients: a case-control study
Kaohsiung J Med Sci (2018) 34, 634-642. PubMed Europe PubMed DOI M
Mangiatordi,G.F., Guzzo,T., Rossano,E.C., Trisciuzzi,D., Alberga,D., Fasciglione,G., Coletta,M., Topai,A. and Nicolotti,O.
Design, synthesis, and biological evaluation of tetrahydro-beta-carboline derivatives as selective sub-nanomolar gelatinase inhibitors
ChemMedChem (2018) 13, 1343-1352. PubMed Europe PubMed DOI I
Nguyen,T.T., Ding,D., Wolter,W.R., Perez,R.L., Champion,M.M., Mahasenan,K.V., Hesek,D., Lee,M., Schroeder,V.A., Jones,J.I., Lastochkin,E., Rose,M.K., Peterson,C.E., Suckow,M.A., Mobashery,S. and Chang,M.
Validation of matrix metalloproteinase-9 (MMP-9) as a novel target for treatment of diabetic foot ulcers in humans and discovery of a potent and selective small-molecule MMP-9 inhibitor that accelerates healing
J Med Chem (2018) 61, 8825-8837. PubMed Europe PubMed DOI I
Pelay-Gimeno,M., Bange,T., Hennig,S. and Grossmann,T.N.
In situ cyclization of native proteins: structure-based design of a bicyclic enzyme
Angew Chem Int Ed Engl (2018) 57, 11164-11170. PubMed Europe PubMed DOI A
Pradiba,D., Aarthy,M., Shunmugapriya,V., Singh,S.K. and Vasanthi,M.
Structural insights into the binding mode of flavonols with the active site of matrix metalloproteinase-9 through molecular docking and molecular dynamic simulations studies
J Biomol Struct Dyn (2018) 36, 3718-3739. PubMed Europe PubMed DOI I
Rojas-Quintero,J., Wang,X., Tipper,J., Burkett,P.R., Zuniga,J., Ashtekar,A.R., Polverino,F., Rout,A., Yambayev,I., Hernandez,C., Jimenez,L., Ramirez,G., Harrod,K.S. and Owen,C.A.
Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection
JCI Insight (2018) 3 PubMed Europe PubMed DOI K
Ruiz-Vega,G., Garcia-Robaina,A., Ben Ismail,M., Pasamar,H., Garcia-Berrocoso,T., Montaner,J., Zourob,M., Othmane,A., Del Campo,F.J. and Baldrich,E.
Detection of plasma MMP-9 within minutes. Unveiling some of the clues to develop fast and simple electrochemical magneto-immunosensors
Biosens Bioelectron (2018) 115, 45-52. PubMed Europe PubMed DOI A
Sandborn,W.J., Bhandari,B.R., Randall,C., Younes,Z.H., Romanczyk,T., Xin,Y., Wendt,E., Chai,H., McKevitt,M., Zhao,S., Sundy,J.S., Keshav,S. and Danese,S.
Andecaliximab [anti-matrix metalloproteinase-9] induction therapy for ulcerative colitis: a randomised, double-blind, placebo-controlled, phase 2/3 study in patients with moderate to severe disease
J Crohns Colitis (2018) 12, 1021-1029. PubMed Europe PubMed DOI
Shirian,J., Arkadash,V., Cohen,I., Sapir,T., Radisky,E.S., Papo,N. and Shifman,J.M.
Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14
FEBS Lett (2018) 592, 1122-1134. PubMed Europe PubMed DOI
Swetha,R., Gayen,C., Kumar,D., Singh,T.D., Modi,G. and Singh,S.K.
Biomolecular basis of matrix metallo proteinase-9 activity
Future Med Chem (2018) 10, 1093-1112. PubMed Europe PubMed DOI I
Wang,B., Wang,Y. and Zhao,L.
MMP-9 gene rs3918242 polymorphism increases risk of stroke: a meta-analysis
J Cell Biochem (2018) 119, 9801-9808. PubMed Europe PubMed DOI M
Zhang,H., Wang,X., Mao,J., Huang,Y., Xu,W., Duan,Y. and Zhang,J.
Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity
Bioorg Med Chem (2018) 26, 4363-4374. PubMed Europe PubMed DOI I
Zhu,Y., Huang,R.Z., Wang,C.G., Ouyang,X.L., Jing,X.T., Liang,D. and Wang,H.S.
New inhibitors of matrix metalloproteinases 9 (MMP-9): lignans from Selaginella moellendorffii
Fitoterapia (2018) 130, 281-289. PubMed Europe PubMed DOI I

2017

Alford,V.M., Kamath,A., Ren,X., Kumar,K., Gan,Q., Awwa,M., Tong,M., Seeliger,M.A., Cao,J., Ojima,I. and Sampson,N.S.
Targeting the hemopexin-like domain of latent matrix metalloproteinase-9 (proMMP-9) with a small molecule inhibitor prevents the formation of focal adhesion junctions
ACS Chem Biol (2017) 12, 2788-2803. PubMed Europe PubMed DOI I
Appleby,T.C., Greenstein,A.E., Hung,M., Liclican,A., Velasquez,M., Villasenor,A.G., Wang,R., Wong,M.H., Liu,X., Papalia,G.A., Schultz,B.E., Sakowicz,R., Smith,V. and Kwon,H.J.
Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9
J Biol Chem (2017) 292, 6810-6820. PubMed Europe PubMed DOI PMC EPMC
Dang,B., Duan,X., Wang,Z., He,W. and Chen,G.
A therapeutic target of cerebral hemorrhagic stroke: matrix metalloproteinase-9
Curr Drug Targets (2017) 18, 1358-1366. PubMed Europe PubMed DOI V
He,T., Wang,J., Wang,X.L., Deng,W.S. and Sun,P.
Association between the matrix metalloproteinase-9 rs3918242 polymorphism and ischemic stroke susceptibility: a meta-analysis
J Stroke Cerebrovasc Dis (2017) 26, 1136-1143. PubMed Europe PubMed DOI M
Lepeta,K., Purzycka,K.J., Pachulska-Wieczorek,K., Mitjans,M., Begemann,M., Vafadari,B., Bijata,K., Adamiak,R.W., Ehrenreich,H., Dziembowska,M. and Kaczmarek,L.
A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms
EMBO Mol Med (2017) 9, 1100-1116. PubMed Europe PubMed DOI M
Nuti,E., Rosalia,L., Cuffaro,D., Camodeca,C., Giacomelli,C., Da Pozzo,E., Tuccinardi,T., Costa,B., Antoni,C., Vera,L., Ciccone,L., Orlandini,E., Nencetti,S., Dive,V., Martini,C., Stura,E.A. and Rossello,A.
Bifunctional inhibitors as a new tool to reduce cancer cell invasion by impairing MMP-9 homodimerization
ACS Med Chem Lett (2017) 8, 293-298. PubMed Europe PubMed DOI PMC EPMC I
Reid,J.C., Matsika,A., Davies,C.M., He,Y., Broomfield,A., Bennett,N.C., Magdolen,V., Srinivasan,B., Clements,J.A. and Hooper,J.D.
Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases
Am J Cancer Res (2017) 7, 2257-2274. PubMed Europe PubMed PMC EPMC
Scannevin,R.H., Alexander,R., Haarlander,T.M., Burke,S.L., Singer,M., Huo,C., Zhang,Y.M., Maguire,D., Spurlino,J., Deckman,I., Carroll,K.I., Lewandowski,F., Devine,E., Dzordzorme,K., Tounge,B., Milligan,C., Bayoumy,S., Williams,R., Schalk-Hihi,C., Leonard,K., Jackson,P., Todd,M., Kuo,L.C. and Rhodes,K.J.
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation
J Biol Chem (2017) 292, 17963-17974. PubMed Europe PubMed DOI I
Xu,J., Zhao,L., Zhou,H., Ge,T. and Zhang,L.
Association of MMP-9 C-1562T polymorphism with risk of Henoch-Schonlein purpura nephritis in children of southeast China
Genes Genomics (2017) 39, 379-385. DOI M
Yuan,G., Chen,L., Feng,J., Yang,G., Ni,Q., Xu,X., Wan,C., Lindsey,M., Donly,K.J., MacDougall,M., Chen,Z. and Chen,S.
Dentin sialoprotein is a novel substrate of matrix metalloproteinase 9 in vitro and in vivo
Sci Rep (2017) 7, 42449-42449. PubMed Europe PubMed DOI PMC EPMC

2016

Alluri,H., Wilson,R.L., Anasooya Shaji,C., Wiggins-Dohlvik,K., Patel,S., Liu,Y., Peng,X., Beeram,M.R., Davis,M.L., Huang,J.H. and Tharakan,B.
Melatonin preserves blood-brain barrier integrity and permeability via matrix metalloproteinase-9 inhibition
PLoS ONE (2016) 11, e0154427-e0154427. PubMed Europe PubMed DOI I
Bae,M.J., Karadeniz,F., Lee,S.G., Seo,Y. and Kong,C.S.
Inhibition of MMP-2 and MMP-9 activities by Limonium tetragonum extract
Prev Nutr Food Sci (2016) 21, 38-43. PubMed Europe PubMed DOI PMC EPMC I
Davis,E.L., Sonnet,C., Lazard,Z.W., Henslee,G., Gugala,Z., Salisbury,E.A., Strecker,E.V., Davis,T.A., Forsberg,J.A., Davis,A.R. and Olmsted-Davis,E.A.
Location-dependent heterotopic ossification in the rat model: the role of activated matrix metalloproteinase 9
J Orthop Res (2016) 34, 1894-1904. PubMed Europe PubMed DOI
Gerwien,H., Hermann,S., Zhang,X., Korpos,E., Song,J., Kopka,K., Faust,A., Wenning,C., Gross,C.C., Honold,L., Melzer,N., Opdenakker,G., Wiendl,H., Schafers,M. and Sorokin,L.
Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
Sci Transl Med (2016) 8, 364ra152-364ra. PubMed Europe PubMed DOI L
Grunwald,B., Vandooren,J., Gerg,M., Ahomaa,K., Hunger,A., Berchtold,S., Akbareian,S., Schaten,S., Knolle,P., Edwards,D.R., Opdenakker,G. and Kruger,A.
Systemic ablation of MMP-9 triggers invasive growth and metastasis of pancreatic cancer via deregulation of IL6 expression in the bone marrow
Mol Cancer Res (2016) 14, 1147-1158. PubMed Europe PubMed DOI K
He,W., Jiang,J., Yu,Z.Q. and Zhou,J.H.
Novel 5-hydroxy, 5-substituted benzenesulfonamide pyrimidine-2,4,6-triones attenuate lipopolysaccharide-induced acute lung injury via inhibition of the gelatinases, MMP-2 and MMP-9
Drug Dev Res (2016) 77, 251-257. PubMed Europe PubMed DOI I
Iyer,R.P., de Castro Bras,L.E., Patterson,N.L., Bhowmick,M., Flynn,E.R., Asher,M., Cannon,P.L., Deleon-Pennell,K.Y., Fields,G.B. and Lindsey,M.L.
Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution
J Mol Cell Cardiol (2016) 100, 109-117. PubMed Europe PubMed DOI I
Kalva,S., Agrawal,N., Skelton,A.A. and Saleena,L.M.
Identification of novel selective MMP-9 inhibitors as potential anti-metastatic lead using structure-based hierarchical virtual screening and molecular dynamics simulation
Mol Biosyst (2016) 12, 2519-2531. PubMed Europe PubMed DOI I
Kim,K., Punj,V., Kim,J.M., Lee,S., Ulmer,T.S., Lu,W., Rice,J.C. and An,W.
MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis
Genes Dev (2016) 30, 208-219. PubMed Europe PubMed DOI
Kryza,D., Debordeaux,F., Azema,L., Hassan,A., Paurelle,O., Schulz,J., Savona-Baron,C., Charignon,E., Bonazza,P., Taleb,J., Fernandez,P., Janier,M. and Toulme,J.J.
Ex vivo and in vivo imaging and biodistribution of aptamers targeting the human matrix metalloprotease-9 in melanomas
PLoS ONE (2016) 11, e0149387-e0149387. PubMed Europe PubMed DOI L
MedeirosTurra,K., PinedaRivelli,D., BerlangadeMoraesBarros,S. and MesquitaPasqualoto,K.F.
Constructing and validating 3D-pharmacophore models to a set of MMP-9 inhibitors for designing novel anti-melanoma agents
Mol Inform (2016) 35, 238-252. PubMed Europe PubMed DOI I
Mohseni,S., Moghadam,T.T., Dabirmanesh,B. and Khajeh,K.
Expression, purification, refolding and in vitro recovery of active full length recombinant human gelatinase MMP-9 in Escherichia coli
Protein Expr Purif (2016) 126, 42-48. PubMed Europe PubMed DOI E
Nambiar,J., Bose,C., Venugopal,M., Banerji,A., Patel,T.B., Kumar,G.B. and Nair,B.G.
Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK
Exp Cell Res (2016) 349, 139-151. PubMed Europe PubMed DOI I
Sandborn,W.J., Bhandari,B.R., Fogel,R., Onken,J., Yen,E., Zhao,X., Jiang,Z., Ge,D., Xin,Y., Ye,Z., French,D., Silverman,J.A., Kanwar,B., Subramanian,G.M., McHutchison,J.G., Lee,S.D., Shackelton,L.M., Pai,R.K., Levesque,B.G. and Feagan,B.G.
Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis
Aliment Pharmacol Ther (2016) 44, 157-169. PubMed Europe PubMed DOI
Shan,Y., Zhang,Y., Zhuo,X., Li,X., Peng,J. and Fang,W.
Matrix metalloproteinase-9 plays a role in protecting zebrafish from lethal infection with Listeria monocytogenes by enhancing macrophage migration
Fish Shellfish Immunol (2016) 54, 179-187. PubMed Europe PubMed DOI

2015

Apoorv,T.S., Babu,P.P., Meese,S., Gai,P.P., Bedu-Addo,G. and Mockenhaupt,F.P.
Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria
Am J Trop Med Hyg (2015) 93, 186-188. PubMed Europe PubMed DOI M
Behrends,M., Wagner,S., Kopka,K., Schober,O., Schafers,M., Kumbhar,S., Waller,M. and Haufe,G.
New matrix metalloproteinase inhibitors based on gamma-fluorinated alpha-aminocarboxylic and alpha-aminohydroxamic acids
Bioorg Med Chem (2015) 23, 3809-3818. PubMed Europe PubMed DOI I
Bianchini,F., Calugi,C., Ruzzolini,J., Menchi,G., Calorini,L., Guarna,A. and Trabocchi,A.
A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9
MedChemComm (2015) 6, 277-282. DOI I
Biela,A., Watkinson,M., Meier,U.C., Baker,D., Giovannoni,G., Becer,C.R. and Krause,S.
Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopy
Biosens Bioelectron (2015) 68C, 660-667. PubMed Europe PubMed DOI A
Christensen,J. and Shastri,V.P.
Matrix-metalloproteinase-9 is cleaved and activated by cathepsin K
BMC Res Notes (2015) 8, 322-322. PubMed Europe PubMed DOI PMC EPMC
Christoffersson,G., Walden,T., Sandberg,M., Opdenakker,G., Carlsson,P.O. and Phillipson,M.
Matrix metalloproteinase-9 is essential for physiological beta cell function and islet vascularization in adult mice
Am J Pathol (2015) 185, 1094-1103. PubMed Europe PubMed DOI K
Gupta,B., Mai,K., Lowe,S.B., Wakefield,D., Di Girolamo,N., Gaus,K., Reece,P.J. and Gooding,J.J.
Ultrasensitive and specific measurement of protease activity using functionalized photonic crystals
Anal Chem (2015) 87, 9946-9953. PubMed Europe PubMed DOI A
Hou,Y., Zhou,J., Gao,Z., Sun,X., Liu,C., Shangguan,D., Yang,W. and Gao,M.
Protease-activated ratiometric fluorescent probe for pH mapping of malignant tumors
ACS Nano (2015) 9, 3199-3205. PubMed Europe PubMed DOI L
Jallouk,A.P., Palekar,R.U., Marsh,J.N., Pan,H., Pham,C.T., Schlesinger,P.H. and Wickline,S.A.
Delivery of a protease-activated cytolytic peptide prodrug by perfluorocarbon nanoparticles
Bioconjug Chem (2015) 26, 1640-1650. PubMed Europe PubMed DOI
Kawatani,M., Fukushima,Y., Kondoh,Y., Honda,K., Sekine,T., Yamaguchi,Y., Taniguchi,N. and Osada,H.
Identification of matrix metalloproteinase inhibitors by chemical arrays
Biosci Biotechnol Biochem (2015) 79, 1597-1602. PubMed Europe PubMed DOI I
LeBert,D.C., Squirrell,J.M., Rindy,J., Broadbridge,E., Lui,Y., Zakrzewska,A., Eliceiri,K.W., Meijer,A.H. and Huttenlocher,A.
Matrix metalloproteinase 9 modulates collagen matrices and wound repair
Development (2015) 142, 2136-2146. PubMed Europe PubMed DOI
Lindsey,M.L., Zouein,F.A., Tian,Y., Padmanabhan Iyer,R. and de Castro Bras,L.E.
Osteopontin is proteolytically processed by matrix metalloproteinase 9
Can J Physiol Pharmacol (2015) 93, 879-886. PubMed Europe PubMed DOI P
Nanjan,P., Nambiar,J., Nair,B.G. and Banerji,A.
Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9
Bioorg Med Chem (2015) 23, 3781-3787. PubMed Europe PubMed DOI I
Nuti,E., Cantelmo,A.R., Gallo,C., Bruno,A., Bassani,B., Camodeca,C., Tuccinardi,T., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Martinelli,A., Dive,V., Albini,A. and Rossello,A.
N-O-Isopropyl sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors: hit selection and in vivo antiangiogenic activity
J Med Chem (2015) 58, 7224-7240. PubMed Europe PubMed DOI I
Perunovic,N., Rakic,M., Jankovic,S., Aleksic,Z., Struillou,X., Cakic,S., Puletic,M., Lekovic,V. and Milasin,J.
MMP-9 -1562 C>T (rs3918242) promoter polymorphism as a susceptibility factor for multiple gingival recessions
Int J Periodontics Restorative Dent (2015) 35, 263-269. PubMed Europe PubMed M
Trentini,A., Manfrinato,M.C., Castellazzi,M., Tamborino,C., Roversi,G., Volta,C.A., Baldi,E., Tola,M.R., Granieri,E., Dallocchio,F., Bellini,T. and Fainardi,E.
TIMP-1 resistant matrix metalloproteinase-9 is the predominant serum active isoform associated with MRI activity in patients with multiple sclerosis
Mult Scler (2015) 21, 1121-1130. PubMed Europe PubMed DOI
Vandooren,J., Born,B., Solomonov,I., Zajac,E., Saldova,R., Senske,M., Ugarte-Berzal,E., Martens,E., Van Den Steen,P.E., Van Damme,J., Garcia-Pardo,A., Froeyen,M., Deryugina,E.I., Quigley,J.P., Moestrup,S.K., Rudd,P.M., Sagi,I. and Opdenakker,G.
Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1
Biochem J (2015) 465, 259-270. PubMed Europe PubMed DOI
Yan,X.Q., Wang,Z.C., Li,Z., Wang,P.F., Qiu,H.Y., Chen,L.W., Lu,X.Y., Lv,P.C. and Zhu,H.L.
Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: design, synthesis, inhibitory activity and 3D-QSAR analysis
Bioorg Med Chem Lett (2015) 25, 4664-4671. PubMed Europe PubMed DOI I
Yang,W., Lu,J., Yang,L. and Zhang,J.
Association of matrix metalloproteinase-9 gene -1562C/T polymorphism with essential hypertension: a systematic review and meta-analysis article
Iran J Public Health (2015) 44, 1445-1452. PubMed Europe PubMed PMC EPMC M V
Zapico,J.M., Puckowska,A., Filipiak,K., Coderch,C., de Pascual-Teresa,B. and Ramos,A.
Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family
Org Biomol Chem (2015) 13, 142-156. PubMed Europe PubMed DOI I

2014

Bremmer,S.C., McNeil,A.J. and Soellner,M.B.
Enzyme-triggered gelation: targeting proteases with internal cleavage sites
Chem Commun (Camb) (2014) 50, 1691-1693. PubMed Europe PubMed DOI A
Chiranjeevi,P., Spurthi,K.M., Rani,N.S., Kumar,G.R., Aiyengar,T.M., Saraswati,M., Srilatha,G., Kumar,G.K., Sinha,S., Kumari,C.S., Reddy,B.N., Vishnupriya,S. and Rani,H.S.
Gelatinase B (-1562C/T) polymorphism in tumor progression and invasion of breast cancer
Tumour Biol (2014) 35, 1351-1356. PubMed Europe PubMed DOI M
de Castro Bras,L.E., Cates,C.A., Deleon-Pennell,K.Y., Ma,Y., Iyer,R.P., Halade,G.V., Yabluchanskiy,A., Fields,G.B., Weintraub,S.T. and Lindsey,M.L.
Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle
Antioxid Redox Signal (2014) 21, 1974-1985. PubMed Europe PubMed DOI
Fudala,R., Rich,R., Mukerjee,A., Ranjan,A.P., Vishwanatha,J.K., Kurdowska,A.K., Gryczynski,Z., Borejdo,J. and Gryczynski,I.
Fluorescence detection of MMP-9. II. Ratiometric FRET-based sensing with dually labeled specific peptide
Curr Pharm Biotechnol (2014) 14, 1134-1138. PubMed Europe PubMed DOI A
Kalva,S., Azhagiya Singam,E.R., Rajapandian,V., Saleena,L.M. and Subramanian,V.
Discovery of potent inhibitor for matrix metalloproteinase-9 by pharmacophore based modeling and dynamics simulation studies
J Mol Graph Model (2014) 49, 25-37. PubMed Europe PubMed DOI I
Kaplan,A., Spiller,K.J., Towne,C., Kanning,K.C., Choe,G.T., Geber,A., Akay,T., Aebischer,P. and Henderson,C.E.
Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration
Neuron (2014) 81, 333-348. PubMed Europe PubMed DOI T
Korol,A., Pino,G., Dwivedi,D., Robertson,J.V., Deschamps,P.A. and West-Mays,J.A.
Matrix metalloproteinase-9-null mice are resistant to TGF-beta-induced anterior subcapsular cataract formation
Am J Pathol (2014) 184, 2001-2012. PubMed Europe PubMed DOI K
Lauer,J.L., Bhowmick,M., Tokmina-Roszyk,D., Lin,Y., Van Doren,S.R. and Fields,G.B.
The role of collagen charge clusters in the modulation of matrix metalloproteinase activity
J Biol Chem (2014) 289, 1981-1992. PubMed Europe PubMed DOI P
Mohammad,G., Vandooren,J., Siddiquei,M.M., Martens,E., Abu El-Asrar,A.M. and Opdenakker,G.
Functional links between gelatinase B/matrix metalloproteinase-9 and prominin-1/CD133 in diabetic retinal vasculopathy and neuropathy
Prog Retin Eye Res (2014) 43, 76-91. PubMed Europe PubMed
Opstad,T.B., Arnesen,H., Pettersen,A.A. and Seljeflot,I.
The mmp-9 -1562 c/t polymorphism in the presence of metabolic syndrome increases the risk of clinical events in patients with coronary artery disease
PLoS ONE (2014) 9, e106816-e106816. PubMed Europe PubMed DOI PMC EPMC M
Rossano,R., Larocca,M., Riviello,L., Coniglio,M.G., Vandooren,J., Liuzzi,G.M., Opdenakker,G. and Riccio,P.
Heterogeneity of serum gelatinases MMP-2 and MMP-9 isoforms and charge variants
J Cell Mol Med (2014) 18, 242-252. PubMed Europe PubMed DOI
Sidhu,H., Dansie,L.E., Hickmott,P.W., Ethell,D.W. and Ethell,I.M.
Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model
J Neurosci (2014) 34, 9867-9879. PubMed Europe PubMed DOI K
Sonderegger,P. and Matsumoto-Miyai,K.
Activity-controlled proteolytic cleavage at the synapse
Trends Neurosci (2014) 37, 413-423. PubMed Europe PubMed DOI
Stawarski,M., Rutkowska-Wlodarczyk,I., Zeug,A., Bijata,M., Madej,H., Kaczmarek,L. and Wlodarczyk,J.
Genetically encoded FRET-based biosensor for imaging MMP-9 activity
Biomaterials (2014) 35, 1402-1410. PubMed Europe PubMed DOI L
Tranchant,I., Vera,L., Czarny,B., Amoura,M., Cassar,E., Beau,F., Stura,E.A. and Dive,V.
Halogen bonding controls selectivity of FRET substrate probes for MMP-9
Chem Biol (2014) 21, 408-413. PubMed Europe PubMed DOI A
van Duijnhoven,S.M., Robillard,M.S., Hermann,S., Kuhlmann,M.T., Schafers,M., Nicolay,K. and Grull,H.
Imaging of MMP activity in postischemic cardiac remodeling using radiolabeled MMP-2/9 activatable peptide probes
Mol Pharm (2014) 11, 1415-1423. PubMed Europe PubMed DOI L
Vandooren,J., Van Damme,J. and Opdenakker,G.
On the structure and functions of gelatinase B/matrix metalloproteinase-9 in neuroinflammation
Prog Brain Res (2014) 214, 193-206. PubMed Europe PubMed DOI
Verma,A., Rizvi,S.M., Shaikh,S., Ansari,M.A., Shakil,S., Ghazal,F., Siddiqui,M.H., Haneef,M. and Rehman,A.
Compounds isolated from Ageratum houstonianum inhibit the activity of matrix metalloproteinases (MMP-2 and MMP-9): an oncoinformatics study
Pharmacogn Mag (2014) 10, 18-26. PubMed Europe PubMed DOI PMC EPMC I
Wang,L., Wang,J., Wang,Y., Fu,Q., Lei,Y.H., Nie,Z.Y., Qiu,J. and Bao,T.Y.
Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure
Exp Ther Med (2014) 7, 329-334. PubMed Europe PubMed DOI PMC EPMC U
Zhang,T., Xu,J., Li,D., Chen,J., Shen,X., Xu,F., Teng,F., Deng,Y., Ma,H., Zhang,L., Zhang,G., Zhang,Z., Wu,W., Liu,X., Yang,M., Jiang,B. and Guo,D.
Salvianolic acid A, a matrix metalloproteinase-9 inhibitor of Salvia miltiorrhiza, attenuates aortic aneurysm formation in apolipoprotein E-deficient mice
Phytomedicine (2014) 21, 1137-1145. PubMed Europe PubMed DOI I
Zhang,X., Bresee,J., Cheney,P.P., Xu,B., Bhowmick,M., Cudic,M., Fields,G.B. and Edwards,W.B.
Evaluation of a triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity
Molecules (2014) 19, 8571-8588. PubMed Europe PubMed DOI L
Zhang,X., Bresee,J., Fields,G.B. and Edwards,W.B.
Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo
Bioorg Med Chem Lett (2014) 24, 3786-3790. PubMed Europe PubMed DOI L

2013

Freskos,J.N., Asmelash,B., Gaston,K.R., Karwa,A., Marzan,T.A., Nickols,M.A., Rogers,T.E., Schoenstein,T., Sympson,C.J. and Vu,B.
Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes
Bioorg Med Chem Lett (2013) 23, 5566-5570. PubMed Europe PubMed DOI L I
Hadass,O., Tomlinson,B.N., Gooyit,M., Chen,S., Purdy,J.J., Walker,J.M., Zhang,C., Giritharan,A.B., Purnell,W., Robinson,C.R.2., Shin,D., Schroeder,V.A., Suckow,M.A., Simonyi,A., Sun,G.Y., Mobashery,S., Cui,J., Chang,M. and Gu,Z.
Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury
PLoS ONE (2013) 8, e76904-e76904. PubMed Europe PubMed DOI PMC EPMC I
Hawkins,K.E., Demars,K.M., Yang,C., Rosenberg,G.A. and Candelario-Jalil,E.
Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke
Mol Brain (2013) 6, 14-14. PubMed Europe PubMed DOI A L
Huang,Y., Shi,J., Yuan,D., Zhou,N. and Xu,B.
Length-dependent proteolytic cleavage of short oligopeptides catalyzed by matrix metalloprotease-9
Biopolymers (2013) 100, 790-795. PubMed Europe PubMed DOI P
Hugenberg,V., Riemann,B., Hermann,S., Schober,O., Schafers,M., Szardenings,K., Lebedev,A., Gangadharmath,U., Kolb,H., Walsh,J., Zhang,W., Kopka,K. and Wagner,S.
Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (Radio)synthesis, in vitro and first in vivo evaluation
J Med Chem (2013) 56, 6858-6870. PubMed Europe PubMed DOI I
Ji,M.K., Shi,Y., Xu,J.W., Lin,X. and Lin,J.Y.
Recombinant snake venom metalloproteinase inhibitor BJ46A inhibits invasion and metastasis of B16F10 and MHCC97H cells through reductions of matrix metalloproteinases 2 and 9 activities
Anticancer Drugs (2013) 24, 461-472. PubMed Europe PubMed DOI E U
Kaczmarek,L.
Mmp-9 inhibitors in the brain: can old bullets shoot new targets?
Curr Pharm Des (2013) 19, 1085-1089. PubMed Europe PubMed I
Kalva,S., Vinod,D. and Saleena,L.M.
Field- and Gaussian-based 3D-QSAR studies on barbiturate analogs as MMP-9 inhibitors
Med Chem Res (2013) 22, 5303-5313. DOI I
Knapska,E., Lioudyno,V., Kiryk,A., Mikosz,M., Gorkiewicz,T., Michaluk,P., Gawlak,M., Chaturvedi,M., Mochol,G., Balcerzyk,M., Wojcik,D.K., Wilczynski,G.M. and Kaczmarek,L.
Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala
J Neurosci (2013) 33, 14591-14600. PubMed Europe PubMed DOI K
Rudra,D.S., Pal,U., Maiti,N.C., Reiter,R.J. and Swarnakar,S.
Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site
J Pineal Res (2013) 54, 398-405. PubMed Europe PubMed DOI I
Ryu,J.H., Shin,J.Y., Kim,S.A., Kang,S.W., Kim,H., Kang,S., Choi,K., Kwon,I.C., Kim,B.S. and Kim,K.
Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model
Biomaterials (2013) 34, 6871-6881. PubMed Europe PubMed DOI L
Sato,A., Nagase,H., Obinata,D., Fujiwara,K., Fukuda,N., Soma,M., Yamaguchi,K., Kawata,N. and Takahashi,S.
Inhibition of MMP-9 using a pyrrole-imidazole polyamide reduces cell invasion in renal cell carcinoma
Int J Oncol (2013) 43, 1441-1446. PubMed Europe PubMed DOI I
Shi,Z.H., Li,N.G., Shi,Q.P., Tang,H., Tang,Y.P., Li,W., Yin,L., Yang,J.P. and Duan,J.A.
Design, synthesis and biological evaluation of ferulic acid amides as selective matrix metalloproteinase inhibitors
Med Chem (2013) 9, 947-954. PubMed Europe PubMed DOI I
Singh,K., Agrawal,N.K., Gupta,S.K. and Singh,K.
A functional single nucleotide polymorphism -1562C>T in the matrix metalloproteinase-9 promoter is associated with type 2 diabetes and diabetic foot ulcers
Int J Low Extrem Wounds (2013) 12, 199-204. PubMed Europe PubMed DOI M
Stegemann,C., Didangelos,A., Barallobre-Barreiro,J., Langley,S.R., Mandal,K., Jahangiri,M. and Mayr,M.
Proteomic identification of matrix metalloproteinase substrates in the human vasculature
Circ Cardiovasc Genet (2013) 6, 106-117. PubMed Europe PubMed DOI P
Takai,S., Jin,D., Yamamoto,D., Li,Z.-L., Otsuki,Y. and Miyazaki,M.
Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice
J Pharmacol Sci (2013) 123, 185-194. PubMed Europe PubMed DOI I
Vandooren,J., Van Den Steen,P.E. and Opdenakker,G.
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade
Crit Rev Biochem Mol Biol (2013) 48, 222-272. PubMed Europe PubMed DOI V
Verslegers,M., Lemmens,K., Van Hove,I. and Moons,L.
Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system
Prog Neurobiol (2013) 105, 60-78. PubMed Europe PubMed DOI V
Yabluchanskiy,A., Ma,Y., Iyer,R.P., Hall,M.E. and Lindsey,M.L.
Matrix metalloproteinase-9: many shades of function in cardiovascular disease
Physiology (Bethesda) (2013) 28, 391-403. PubMed Europe PubMed DOI
Zhong,H.A., Arbiser,J. and Bowen,J.P.
Selectivity, binding affinity, and ionization state of matrix metalloproteinase inhibitors
Curr Pharm Des (2013) 19, 4701-4713. PubMed Europe PubMed DOI I

2012

Awla,D., Abdulla,A., Syk,I., Jeppsson,B., Regner,S. and Thorlacius,H.
Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis
J Leukoc Biol (2012) 91, 711-719. PubMed Europe PubMed DOI I
Burkhart,J.L., Diehl,B., Schmitt,M.J. and Kazmaier,U.
A straightforward approach to MMP-2 and MMP-9 inhibitors based on chelate claisen rearrangements
Eur J Org Chem (2012) 2012, 567-575. DOI I
Eisen,A.Z., Sarkar,S.K., Neumann,K.C. and Goldberg,G.I.
Matrix metallopeptidase-9/gelatinase B
[ISSN:978-0-12-407744-7] (2012) 3, 754-763. DOI
Frankowski,H., Gu,Y.H., Heo,J.H., Milner,R. and del Zoppo,G.J.
Use of gel zymography to examine matrix metalloproteinase (gelatinase) expression in brain tissue or in primary glial cultures
Methods Mol Biol (2012) 814, 221-233. PubMed Europe PubMed DOI A
Geurts,N., Becker-Pauly,C., Martens,E., Proost,P., Van Den Steen,P.E., Stocker,W. and Opdenakker,G.
Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3
FEBS Lett (2012) 586, 4264-4269. PubMed Europe PubMed DOI
Metzger,I.F., Luizon,M.R., Lacchini,R. and Tanus-Santos,J.E.
Genetic variants in matrix metalloproteinase-9 gene modify metalloproteinase-9 levels in black subjects
DNA Cell Biol (2012) 31, 504-510. PubMed Europe PubMed DOI M
Mori,M., De Lorenzo,E., Torre,E., Fragai,M., Nativi,C., Luchinat,C. and Arcangeli,A.
A highly soluble matrix metalloproteinase-9 inhibitor for potential treatment of dry eye syndrome
Basic Clin Pharmacol Toxicol (2012) 111, 289-295. PubMed Europe PubMed DOI I
Nicolotti,O., Catto,M., Giangreco,I., Barletta,M., Leonetti,F., Stefanachi,A., Pisani,L., Cellamare,S., Tortorella,P., Loiodice,F. and Carotti,A.
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
Eur J Med Chem (2012) 58, 368-376. PubMed Europe PubMed DOI I
Patchigolla,R.K., Knudson,W. and Schmid,T.M.
Matrix metalloproteinase-9 in a unique proteoglycan form in avian embryonic growth plate cartilage
Arch Biochem Biophys (2012) 520, 42-50. PubMed Europe PubMed DOI
Qiu,Z., Yan,M., Li,Q., Liu,D., Van Den Steen,P.E., Wang,M., Opdenakker,G. and Hu,J.
Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-alpha converting enzyme (TACE/ADAM-17)
J Enzyme Inhib Med Chem (2012) 27, 533-540. PubMed Europe PubMed DOI I
Ranasinghe,H.S., Scheepens,A., Sirimanne,E., Mitchell,M.D., Williams,C.E. and Fraser,M.
Inhibition of MMP-9 activity following hypoxic ischemia in the developing brain using a highly specific inhibitor
Dev Neurosci (2012) 34, 417-427. PubMed Europe PubMed DOI I
Shi,Z.H., Li,N.G., Shi,Q.P., Hao,T. and Tang,Y.P.
Design, synthesis, and preliminary evaluation of substituted cinnamic acid esters as selective matrix metalloproteinase inhibitors
Drug Dev Res (2012) 73, 317-324. DOI I
Suchankova,P., Pettersson,R., Nordenstrom,K., Holm,G. and Ekman,A.
Personality traits and the R668Q polymorphism located in the MMP-9 gene
Behav Brain Res (2012) 228, 232-235. PubMed Europe PubMed DOI M
Topai,A., Breccia,P., Minissi,F., Padova,A., Marini,S. and Cerbara,I.
In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors
Bioorg Med Chem (2012) 20, 2323-2337. PubMed Europe PubMed DOI I
Verhille,M., Benachour,H., Ibrahim,A., Achard,M., Arnoux,P., Barberi-Heyob,M., Andre,J.C., Allonas,X., Baros,F., Vanderesse,R. and Frochot,C.
Photodynamic molecular beacons triggered by MMP-2 and MMP-9: influence of the distance between photosensitizer and quencher onto photophysical properties and enzymatic activation
Curr Med Chem (2012) 19, 5580-5594. PubMed Europe PubMed DOI A

2011

Azhdarinia,A., Wilganowski,N., Robinson,H., Ghosh,P., Kwon,S., Lazard,Z.W., Davis,A.R., Olmsted-Davis,E. and Sevick-Muraca,E.M.
Characterization of chemical, radiochemical and optical properties of a dual-labeled MMP-9 targeting peptide
Bioorg Med Chem (2011) 19, 3769-3776. PubMed Europe PubMed DOI L
Cauwe,B., Martens,E., Sagaert,X., Dillen,C., Geurts,N., Li,S., Mertens,J., Thijs,G., Van Den Steen,P.E., Heremans,H., De Vos,R., Blockmans,D., Arnold,B. and Opdenakker,G.
Deficiency of gelatinase B/MMP-9 aggravates lpr-induced lymphoproliferation and lupus-like systemic autoimmune disease
J Autoimmun (2011) 36, 239-252. PubMed Europe PubMed DOI
Choi,S.S., Ji,A.R., Yu,S.W., Cho,B.H., Park,J.D., Park,J.H., Lee,H.S., Ryu,S.E., Kim,D.H., Kang,J.H. and Lee,S.T.
Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors
Bull Korean Chem Soc (2011) 32, 2032-2038. DOI I
Diehl,B., Hoffmann,T.M., Mueller,N.C., Burkhart,J.L., Kazmaier,U. and Schmitt,M.J.
Novel yeast bioassay for high-throughput screening of matrix metalloproteinase inhibitors
Appl Environ Microbiol (2011) 77, 8573-8577. PubMed Europe PubMed DOI I
Fudala,R., Ranjan,A.P., Mukerjee,A., Vishwanatha,J.K., Gryczynski,Z., Borejdo,J., Sarkar,P. and Gryczynski,I.
Fluorescence detection of MMP-9. I. MMP-9 selectively cleaves Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys peptide
Curr Pharm Biotechnol (2011) 12, 834-838. PubMed Europe PubMed A
Krishnatry,A.S., Kamei,T., Wang,H., Qu,J. and Fung,H.L.
Identification of nitroglycerin-induced cysteine modifications of pro-matrix metalloproteinase-9
Rapid Commun Mass Spectrom (2011) 25, 2291-2298. PubMed Europe PubMed DOI
Liu,H., Liang,G., Abdel-Halim,E.S. and Zhu,J.J.
A sensitive and selective quantum dots-based FRET biosensor for the detection of cancer marker type IV collagenase
Anal Methods (2011) 3, 1797-1801. DOI A
Liu,H. and Shubayev,V.I.
Matrix metalloproteinase-9 controls proliferation of NG2+ progenitor cells immediately after spinal cord injury
Exp Neurol (2011) 231, 236-246. PubMed Europe PubMed DOI I
Magnussen,H., Watz,H., Kirsten,A., Wang,M., Wray,H., Samuelsson,V., Mo,J. and Kay,R.
Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial
Pulm Pharmacol Ther (2011) 24, 563-570. PubMed Europe PubMed DOI I
Mizoguchi,H., Nakade,J., Tachibana,M., Ibi,D., Someya,E., Koike,H., Kamei,H., Nabeshima,T., Itohara,S., Takuma,K., Sawada,M., Sato,J. and Yamada,K.
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus
J Neurosci (2011) 31, 12963-12971. PubMed Europe PubMed DOI
Ramani,V.C., Kaushal,G.P. and Haun,R.S.
Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin domains
Biochim Biophys Acta (2011) 1813, 1525-1531. PubMed Europe PubMed DOI
Sharov,A.A., Schroeder,M., Sharova,T.Y., Mardaryev,A.N., Peters,E.M., Tobin,D.J. and Botchkarev,V.A.
Matrix metalloproteinase-9 is involved in the regulation of hair canal formation
J Invest Dermatol (2011) 131, 257-260. PubMed Europe PubMed DOI
Testero,S.A., Lee,M., Staran,R.T., Espahbodi,M., Llarrull,L.I., Toth,M., Mobashery,S. and Chang,M.
Sulfonate-containing thiiranes as selective gelatinase inhibitors
ACS Med Chem Lett (2011) 2, 177-181. PubMed Europe PubMed DOI I
Testero,S.A., Llarrull,L.I., Fisher,J.F., Chang,M. and Mobashery,S.
Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry
Arkivoc (2011) 2011, 221-236. I
Vandooren,J., Geurts,N., Martens,E., Van Den Steen,P.E., Jonghe,S.D., Herdewijn,P. and Opdenakker,G.
Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain
World J Biol Chem (2011) 2, 14-24. PubMed Europe PubMed DOI PMC EPMC I
Wang,J., Medina,C., Radomski,M.W. and Gilmer,J.F.
N-Substituted homopiperazine barbiturates as gelatinase inhibitors
Bioorg Med Chem (2011) 19, 4985-4999. PubMed Europe PubMed DOI I
Wilson,L.J., Wang,B., Yang,S.M., Scannevin,R.H., Burke,S.L., Karnachi,P., Rhodes,K.J. and Murray,W.V.
Discovery of novel cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy
Bioorg Med Chem Lett (2011) 21, 6485-6490. PubMed Europe PubMed DOI I
Xu,X., Jackson,P.L., Tanner,S., Hardison,M.T., Abdul Roda,M., Blalock,J.E. and Gaggar,A.
A self-propagating matrix metalloprotease-9 (mmp-9) dependent cycle of chronic neutrophilic inflammation
PLoS ONE (2011) 6, e15781-e15781. PubMed Europe PubMed DOI PMC EPMC
Zhong,H., Wees,M.A., Faure,T.D., Carrillo,C., Arbiser,J. and Bowen,J.P.
The impact of ionization states of matrix metalloproteinase inhibitors on docking-based inhibitor design
ACS Med Chem Lett (2011) 2, 455-460. PubMed Europe PubMed DOI I

2010

Becker,D.P., Barta,T.E., Bedell,L.J., Boehm,T.L., Bond,B.R., Carroll,J., Carron,C.P., Decrescenzo,G.A., Easton,A.M., Freskos,J.N., Funckes-Shippy,C.L., Heron,M., Hockerman,S., Howard,C.P., Kiefer,J.R., Li,M.H., Mathis,K.J., McDonald,J.J., Mehta,P.P., Munie,G.E., Sunyer,T., Swearingen,C.A., Villamil,C.I., Welsch,D., Williams,J.M., Yu,Y. and Yao,J.
Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease
J Med Chem (2010) 53, 6653-6680. PubMed Europe PubMed DOI I
Gorkiewicz,T., Szczuraszek,K., Wyrembek,P., Michaluk,P., Kaczmarek,L. and Mozrzymas,J.W.
Matrix metalloproteinase-9 reversibly affects the time course of NMDA-induced currents in cultured rat hippocampal neurons
Hippocampus (2010) 20, 1105-1108. PubMed Europe PubMed DOI
Heinz,A., Jung,M.C., Duca,L., Sippl,W., Taddese,S., Ihling,C., Rusciani,A., Jahreis,G., Weiss,A.S., Neubert,R.H. and Schmelzer,C.E.
Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines
FEBS J (2010) 277, 1939-1956. PubMed Europe PubMed DOI P
Jiang,B., Chen,J., Xu,L., Gao,Z., Deng,Y., Wang,Y., Xu,F., Shen,X. and Guo,D.
Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling
BMC Pharmacol (2010) 10, 10-10. PubMed Europe PubMed DOI I
Rasch,M.G., Lund,I.K., Illemann,M., Hoyer-Hansen,G. and Gardsvoll,H.
Purification and characterization of recombinant full-length and protease domain of murine MMP-9 expressed in Drosophila S2 cells
Protein Expr Purif (2010) 72, 87-94. PubMed Europe PubMed DOI E
Rosenblum,G., Van Den Steen,P.E., Cohen,S.R., Bitler,A., Brand,D.D., Opdenakker,G. and Sagi,I.
Direct visualization of protease action on collagen triple helical structure
PLoS ONE (2010) 5, e11043-e11043. PubMed Europe PubMed DOI PMC EPMC
Sato,H. and Takino,T.
Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion
Cancer Sci (2010) 101, 843-847. PubMed Europe PubMed DOI V
Ulmer,T.A., Keeler,V., Andre,S., Gabius,H.J., Loh,L. and Laferte,S.
The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic cleavage
Biochim Biophys Acta (2010) 1800, 336-343. PubMed Europe PubMed DOI
Van Hul,M., Piccard,H. and Lijnen,H.R.
Gelatinase B (MMP-9) deficiency does not affect murine adipose tissue development
Thromb Haemost (2010) 104, 165-171. PubMed Europe PubMed DOI K
Wang,X., Zhou,Y., Tan,R., Xiong,M., He,W., Fang,L., Wen,P., Jiang,L. and Yang,J.
Mice lacking the matrix metalloproteinase-9 gene reduce renal interstitial fibrosis in obstructive nephropathy
Am J Physiol Renal Physiol (2010) 299, F973-F982. PubMed Europe PubMed DOI K
Wang,Y., Su,Y., Xu,Y., Pan,S.H. and Liu,G.D.
Genetic polymorphism c.1562C>T of the MMP-9 is associated with macroangiopathy in type 2 diabetes mellitus
Biochem Biophys Res Commun (2010) 391, 113-117. PubMed Europe PubMed DOI M
Xu,D., McKee,C.M., Cao,Y., Ding,Y., Kessler,B.M. and Muschel,R.J.
Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1
Cancer Res (2010) 70, 6988-6998. PubMed Europe PubMed DOI P
Zhou,Y., Lu,Z.N., Guo,Y.J. and Mei,Y.W.
Favorable effects of MMP-9 knockdown in murine herpes simplex encephalitis using small interfering RNA
Neurol Res (2010) 32, 801-809. PubMed Europe PubMed DOI K

2009

Bannikov,G.A., Lakritz,J., Premanandan,C., Mattoon,J.S. and Abrahamsen,E.J.
Kinetics of inhibition of purified bovine neutrophil matrix metalloproteinase 9 by low-molecular-weight inhibitors
Am J Vet Res (2009) 70, 633-639. PubMed Europe PubMed DOI I
Bonoiu,A., Mahajan,S.D., Ye,L., Kumar,R., Ding,H., Yong,K.T., Roy,I., Aalinkeel,R., Nair,B., Reynolds,J.L., Sykes,D.E., Imperiale,M.A., Bergey,E.J., Schwartz,S.A. and Prasad,P.N.
MMP-9 gene silencing by a Quantum Dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier
Brain Res (2009) 1282, 142-155. PubMed Europe PubMed DOI PMC EPMC
Bozzi,M., Inzitari,R., Sbardell,D., Monaco,S., Pavoni,E., Gioia,M., Marini,S., Morlacchi,S., Sciandra,F., Castagnola,M., Giardina,B., Brancaccio,A. and Coletta,M.
Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site
IUBMB Life (2009) 61, 1143-1152. PubMed Europe PubMed DOI P
Dong,X., Song,Y.N., Liu,W.G. and Guo,X.L.
Mmp-9, a potential target for cerebral ischemic treatment
Curr Neuropharmacol (2009) 7, 269-275. PubMed Europe PubMed DOI PMC EPMC
Dwivedi,A., Slater,S.C. and George,S.J.
MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation
Cardiovasc Res (2009) 81, 178-186. PubMed Europe PubMed DOI
Forbes,C., Shi,Q., Fisher,J.F., Lee,M., Hesek,D., Llarrull,L.I., Toth,M., Gossing,M., Fridman,R. and Mobashery,S.
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases
Chem Biol Drug Des (2009) 74, 527-534. PubMed Europe PubMed DOI PMC EPMC I
Gioia,M., Monaco,S., Van Den Steen,P.E., Sbardella,D., Grasso,G., Marini,S., Overall,C.M., Opdenakker,G. and Coletta,M.
The collagen binding domain of gelatinase A modulates degradation of collagen IV by gelatinase B
J Mol Biol (2009) 386, 419-434. PubMed Europe PubMed DOI
Gooyit,M., Lee,M., Hesek,D., Boggess,B., Oliver,A.G., Fridman,R., Mobashery,S. and Chang,M.
Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors
Chem Biol Drug Des (2009) 74, 535-546. PubMed Europe PubMed DOI I
Huang,P.H., Chen,Y.H., Wang,C.H., Chen,J.S., Tsai,H.Y., Lin,F.Y., Lo,W.Y., Wu,T.C., Sata,M., Chen,J.W. and Lin,S.J.
Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells
Arterioscler Thromb Vasc Biol (2009) 29, 1179-1184. PubMed Europe PubMed DOI
Kolaczkowska,E., Plytycz,B., Arnold,B., Piccard,H. and Opdenakker,G.
Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9
Immunology (2009) 128, e262-e274. PubMed Europe PubMed DOI PMC EPMC K
Kyriakides,T.R., Wulsin,D., Skokos,E.A., Fleckman,P., Pirrone,A., Shipley,J.M., Senior,R.M. and Bornstein,P.
Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis
Matrix Biol (2009) 28, 65-73. PubMed Europe PubMed DOI PMC EPMC K
Lausch,E., Keppler,R., Hilbert,K., Cormier-Daire,V., Nikkel,S., Nishimura,G., Unger,S., Spranger,J., Superti-Furga,A. and Zabel,B.
Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia
Am J Hum Genet (2009) 85, 168-178. PubMed Europe PubMed
Lee,M., Celenza,G., Boggess,B., Blase,J., Shi,Q., Toth,M., Bernardo,M.M., Wolter,W.R., Suckow,M.A., Hesek,D., Noll,B.C., Fridman,R., Mobashery,S. and Chang,M.
A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition
Chem Biol Drug Des (2009) 73, 189-202. PubMed Europe PubMed DOI PMC EPMC I
Li,H., Mittal,A., Makonchuk,D.Y., Bhatnagar,S. and Kumar,A.
Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy
Hum Mol Genet (2009) 18, 2584-2598. PubMed Europe PubMed DOI PMC EPMC T
Raife,T.J., Cao,W., Atkinson,B.S., Bedell,B., Montgomery,R.R., Lentz,S.R., Johnson,G.F. and Zheng,X.L.
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
Blood (2009) 114, 1666-1674. PubMed Europe PubMed DOI PMC EPMC P
Wang,W., Shao,R., Wu,Q., Ke,S., McMurray,J., Lang,F.F., Jr., Charnsangavej,C., Gelovani,J.G. and Li,C.
Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide
Mol Imaging Biol (2009) 11, 424-433. PubMed Europe PubMed DOI L I
Wilson,T.J., Nannuru,K.C. and Singh,R.K.
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction
Mol Cancer Res (2009) 7, 1224-1233. PubMed Europe PubMed DOI

2008

Bellacchio,E. and Paggi,M.G.
Protease-mediated arsenic prodrug strategy in cancer and infectious diseases: a hypothesis for targeted activation
J Cell Physiol (2008) 214, 681-686. PubMed Europe PubMed DOI
Celenza,G., Villegas-Estrada,A., Lee,M., Boggess,B., Forbes,C., Wolter,W.R., Suckow,M.A., Mobashery,S. and Chang,M.
Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor
Chem Biol Drug Des (2008) 71, 187-196. PubMed Europe PubMed DOI I
Chadzinska,M., Baginski,P., Kolaczkowska,E., Savelkoul,H.F. and Kemenade,B.M.
Expression profiles of matrix metalloproteinase 9 in teleost fish provide evidence for its active role in initiation and resolution of inflammation
Immunology (2008) 125, 601-610. PubMed Europe PubMed DOI PMC EPMC
Geurts,N., Martens,E., Van Aelst,I., Proost,P., Opdenakker,G. and Van Den Steen,P.E.
Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3
Biochemistry (2008) 47, 2689-2699. PubMed Europe PubMed DOI
Lauer-Fields,J.L., Whitehead,J.K., Li,S., Hammer,R.P., Brew,K. and Fields,G.B.
Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition
J Biol Chem (2008) 283, 20087-20095. PubMed Europe PubMed DOI PMC EPMC
Lee,M., Hesek,D., Shi,Q., Noll,B.C., Fisher,J.F., Chang,M. and Mobashery,S.
Conformational analyses of thiirane-based gelatinase inhibitors
Bioorg Med Chem Lett (2008) 18, 3064-3067. PubMed Europe PubMed DOI I
Martin,M.D., Carter,K.J., Jean-Philippe,S.R., Chang,M., Mobashery,S., Thiolloy,S., Lynch,C.C., Matrisian,L.M. and Fingleton,B.
Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background
Cancer Res (2008) 68, 6251-6259. PubMed Europe PubMed DOI
Ramu,P., Lobo,L.A., Kukkonen,M., Bjur,E., Suomalainen,M., Raukola,H., Miettinen,M., Julkunen,I., Holst,O., Rhen,M., Korhonen,T.K. and Lahteenmaki,K.
Activation of pro-matrix metalloproteinase-9 and degradation of gelatin by the surface protease PgtE of Salmonella enterica serovar Typhimurium
Int J Med Microbiol (2008) 298, 263-278. PubMed Europe PubMed DOI
Vilen,S.T., Nyberg,P., Hukkanen,M., Sutinen,M., Ylipalosaari,M., Bjartell,A., Paju,A., Haaparanta,V., Stenman,U.H., Sorsa,T. and Salo,T.
Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma
Exp Cell Res (2008) 314, 914-926. PubMed Europe PubMed DOI
Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Huang,Z., Karnachi,P., Wilson,L.J., Rhodes,K.J., Lagu,B. and Murray,W.V.
beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents
Bioorg Med Chem Lett (2008) 18, 1140-1145. PubMed Europe PubMed DOI I
Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Wilson,L.J., Karnachi,P., Rhodes,K.J., Lagu,B. and Murray,W.V.
beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. design, synthesis, and lead identification
Bioorg Med Chem Lett (2008) 18, 1135-1139. PubMed Europe PubMed DOI I

2007

Ardi,V.C., Kupriyanova,T.A., Deryugina,E.I. and Quigley,J.P.
Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis
Proc Natl Acad Sci U S A (2007) 104, 20262-20267. PubMed Europe PubMed DOI PMC EPMC
Copin,J.C. and Gasche,Y.
Matrix metalloproteinase-9 deficiency has no effect on glial scar formation after transient focal cerebral ischemia in mouse
Brain Res (2007) 1150, 167-173. PubMed Europe PubMed DOI K
Hanaoka,H., Mukai,T., Habashita,S., Asano,D., Ogawa,K., Kuroda,Y., Akizawa,H., Iida,Y., Endo,K., Saga,T. and Saji,H.
Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors
Nucl Med Biol (2007) 34, 503-510. PubMed Europe PubMed DOI L I
Hasebe,T., Kajita,M., Fujimoto,K., Yaoita,Y. and Ishizuya-Oka,A.
Expression profiles of the duplicated matrix metalloproteinase-9 genes suggest their different roles in apoptosis of larval intestinal epithelial cells during Xenopus laevis metamorphosis
Dev Dyn (2007) 236, 2338-2345. PubMed Europe PubMed DOI
Lauer-Fields,J., Brew,K., Whitehead,J.K., Li,S., Hammer,R.P. and Fields,G.B.
Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors
J Am Chem Soc (2007) 129, 10408-10417. PubMed Europe PubMed DOI PMC EPMC I
Lee,M., Villegas-Estrada,A., Celenza,G., Boggess,B., Toth,M., Kreitinger,G., Forbes,C., Fridman,R., Mobashery,S. and Chang,M.
Metabolism of a highly selective gelatinase inhibitor generates active metabolite
Chem Biol Drug Des (2007) 70, 371-382. PubMed Europe PubMed DOI I
Leira,R., Sobrino,T., Rodriguez-Yanez,M., Blanco,M., Arias,S. and Castillo,J.
MMP-9 immunoreactivity in acute migraine
Headache (2007) 47, 698-702. PubMed Europe PubMed DOI
Martens,E., Leyssen,A., Van Aelst,I., Fiten,P., Piccard,H., Hu,J., Descamps,F.J., Van Den Steen,P.E., Proost,P., Van Damme,J., Liuzzi,G.M., Riccio,P., Polverini,E. and Opdenakker,G.
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains
Biochim Biophys Acta (2007) 1770, 178-186. PubMed Europe PubMed DOI
Nagy,V., Bozdagi,O. and Huntley,G.W.
The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory
Learn Mem (2007) 14, 655-664. PubMed Europe PubMed DOI PMC EPMC
Overall,C.M. and Butler,G.S.
Protease yoga: extreme flexibility of a matrix metalloproteinase
Structure (2007) 15, 1159-1161. PubMed Europe PubMed DOI
Ries,C., Pitsch,T., Mentele,R., Zahler,S., Egea,V., Nagase,H. and Jochum,M.
Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1
Biochem J (2007) 405, 547-558. PubMed Europe PubMed DOI PMC EPMC I
Roderfeld,M., Graf,J., Giese,B., Salguero-Palacios,R., Tschuschner,A., Muller-Newen,G. and Roeb,E.
Latent MMP-9 is bound to TIMP-1 before secretion
Biol Chem (2007) 388, 1227-1234. PubMed Europe PubMed DOI
Rosenblum,G., Van Den Steen,P.E., Cohen,S.R., Grossmann,J.G., Frenkel,J., Sertchook,R., Slack,N., Strange,R.W., Opdenakker,G. and Sagi,I.
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B
Structure (2007) 15, 1227-1236. PubMed Europe PubMed DOI S
Rosenblum,G., Meroueh,S., Toth,M., Fisher,J.F., Fridman,R., Mobashery,S. and Sagi,I.
Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma
J Am Chem Soc (2007) 129, 13566-13574. PubMed Europe PubMed DOI
Roy,J.S., Van Themsche,C., Demers,M., Opdenakker,G., Arnold,B. and St-Pierre,Y.
Triggering of T-cell leukemia and dissemination of T-cell lymphoma in MMP-9-deficient mice
Leukemia (2007) 21, 2506-2511. PubMed Europe PubMed DOI K
Tochowicz,A., Maskos,K., Huber,R., Oltenfreiter,R., Dive,V., Yiotakis,A., Zanda,M., Pourmotabbed,T., Bode,W. and Goettig,P.
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity
J Mol Biol (2007) 371, 989-1006. PubMed Europe PubMed DOI S I
Tsukamoto,H., Yokoyama,Y., Suzuki,T., Mizuta,S. and Yoshinaka,R.
Molecular cloning and expression of gelatinases (MMP-2 and MMP-9) in the pufferfish Takifugu rubripes
Comp Biochem Physiol B Biochem Mol Biol (2007) 148, 295-302. PubMed Europe PubMed DOI
Vempati,P., Karagiannis,E.D. and Popel,A.S.
A biochemical model of matrix metalloproteinase 9 activation and inhibition
J Biol Chem (2007) 282, 37585-37596. PubMed Europe PubMed DOI
Xing,L.L., Wang,Z.N., Jiang,L., Zhang,Y., Xu,Y.Y., Li,J., Luo,Y. and Zhang,X.
Matrix metalloproteinase-9-1562C>T polymorphism may increase the risk of lymphatic metastasis of colorectal cancer
World J Gastroenterol (2007) 13, 4626-4629. PubMed Europe PubMed M
Yamamoto,D., Takai,S., Jin,D., Inagaki,S., Tanaka,K. and Miyazaki,M.
Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9
J Mol Cell Cardiol (2007) 43, 670-676. PubMed Europe PubMed DOI I
Yoong,S., O'Connell,B., Soanes,A., Crowhurst,M.O., Lieschke,G.J. and Ward,A.C.
Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern
Gene Expr Patterns (2007) 7, 39-46. PubMed Europe PubMed DOI
Zhou,S., Feely,J., Spiers,J.P. and Mahmud,A.
Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension
J Hum Hypertens (2007) 21, 861-867. PubMed Europe PubMed DOI M

2006

Chen,L., Wang,X., Carter,S.A., Shen,Y.H., Bartsch,H.R., Thompson,R.W., Coselli,J.S., Wilcken,D.L., Wang,X.L. and LeMaire,S.A.
A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (-8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection
J Thorac Cardiovasc Surg (2006) 131, 1045-1052. PubMed Europe PubMed DOI PMC EPMC M
[YEAR:15-8-2006]Di Girolamo,N., Indoh,I., Jackson,N., Wakefield,D., McNeil,H.P., Yan,W., Geczy,C., Arm,J.P. and Tedla,N.
Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration
J Immunol (15-8-2006) 177, 2638-2650. PubMed Europe PubMed
Fujimoto,K., Nakajima,K. and Yaoita,Y.
One of the duplicated matrix metalloproteinase-9 genes is expressed in regressing tail during anuran metamorphosis
Dev Growth Differ (2006) 48, 223-241. PubMed Europe PubMed DOI
Greenlee,K.J., Corry,D.B., Engler,D.A., Matsunami,R.K., Tessier,P., Cook,R.G., Werb,Z. and Kheradmand,F.
Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation
J Immunol (2006) 177, 7312-7321. PubMed Europe PubMed PMC EPMC
[YEAR:2-6-2006]Ishibashi,O., Niwa,S., Kadoyama,K. and Inui,T.
MMP-9 antisense oligodeoxynucleotide exerts an inhibitory effect on osteoclastic bone resorption by suppressing cell migration
Life Sci (2-6-2006) 79, 1657-1660. PubMed Europe PubMed DOI
[YEAR:12-5-2006]Kim,J.H., Suk,M.H., Yoon,D.W., Lee,S.H., Hur,G.Y., Jung,K.H., Jeong,H.C., Lee,S.Y., Lee,S.Y., Suh,I.B., Shin,C., Shim,J.J., In,K.H., Yoo,S.H. and Kang,K.H.
Inhibition of matrix metalloproteinase-9 prevents neutrophilic inflammation in ventilator-induced lung injury
Am J Physiol Lung Cell Mol Physiol (12-5-2006) 291, L580-L587. PubMed Europe PubMed DOI I
[YEAR:22-2-2006]Larsen,P.H., DaSilva,A.G., Conant,K. and Yong,V.W.
Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice
J Neurosci (22-2-2006) 26, 2207-2214. PubMed Europe PubMed DOI K
[YEAR:18-5-2006]Lee,E.R., Lamplugh,L., Kluczyk,B., Mort,J.S. and Leblond,C.P.
Protease analysis by neoepitope approach reveals the activation of MMP-9 is achieved proteolytically in a test tissue cartilage model involved in bone formation
J Histochem Cytochem (18-5-2006) 54, 965-980. PubMed Europe PubMed DOI
[YEAR:26-8-2006]Lindsey,M.L., Escobar,G.P., Dobrucki,L.W., Goshorn,D.K., Bouges,S., Mingoia,J.T., McClister,D.M., Jr., Su,H., Gannon,J., MacGillivray,C., Lee,R.T., Sinusas,A.J. and Spinale,F.G.
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction
Am J Physiol Heart Circ Physiol (26-8-2006) 290, H232-H239. PubMed Europe PubMed DOI K
[YEAR:27-4-2006]Natividad,A., Cooke,G., Holland,M.J., Burton,M.J., Joof,H.M., Rockett,K., Kwiatkowski,D.P., Mabey,D.C. and Bailey,R.L.
A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
BMC Med Genet (27-4-2006) 7, 40-40. PubMed Europe PubMed DOI PMC EPMC M
[YEAR:3-11-2006]Przybylowska,K., Kluczna,A., Zadrozny,M., Krawczyk,T., Kulig,A., Rykala,J., Kolacinska,A., Morawiec,Z., Drzewoski,J. and Blasiak,J.
Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer
Breast Cancer Res Treat (3-11-2006) 95, 65-72. PubMed Europe PubMed DOI M
[YEAR:2-5-2006]Ram,M., Sherer,Y. and Shoenfeld,Y.
Matrix metalloproteinase-9 and autoimmune diseases
J Clin Immunol (2-5-2006) 26, 299-307. PubMed Europe PubMed DOI V
[YEAR:7-6-2006]Yamamoto,S., Nakatani,S., Ikura,M., Sugiura,T., Nishita,Y., Itadani,S., Ogawa,K., Ohno,H., Takahashi,K., Nakai,H. and Toda,M.
Design and synthesis of an orally active matrix metalloproteinase inhibitor
Bioorg Med Chem (7-6-2006) 14, 6383-6403. PubMed Europe PubMed DOI I
Yan,P., Hu,X., Song,H., Yin,K., Bateman,R.J., Cirrito,J.R., Xiao,Q., Hsu,F.F., Turk,J.W., Xu,J., Hsu,C.Y., Holtzman,D.M. and Lee,J.M.
Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ
J Biol Chem (2006) 281, 24566-24574. PubMed Europe PubMed DOI
[YEAR:18-5-2006]Yasmin, McEniery,C.M., O'Shaughnessy,K.M., Harnett,P., Arshad,A., Wallace,S., Maki-Petaja,K., McDonnell,B., Ashby,M.J., Brown,J., Cockcroft,J.R. and Wilkinson,I.B.
Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals
Arterioscler Thromb Vasc Biol (18-5-2006) 26, 1799-1805. PubMed Europe PubMed DOI M
[YEAR:26-9-2006]Zhang,L., Zhang,J., Fang,H., Wang,Q. and Xu,W.
Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors
Bioorg Med Chem (26-9-2006) 14, 8286-8294. PubMed Europe PubMed DOI I

2005

[YEAR:21-6-2005]Banerjee,A.L., Tobwala,S., Haldar,M.K., Swanson,M., Roy,B.C., Mallik,S. and Srivastava,D.K.
Inhibition of matrix metalloproteinase-9 by "multi-prong" surface binding groups
Chem Commun (Camb) (21-6-2005) 2005, 2549-2551. PubMed Europe PubMed DOI I
[YEAR:31-5-2005]Bianchini,G., Aschi,M., Cavicchio,G., Crucianelli,M., Preziuso,S., Gallina,C., Nastari,A., Gavuzzo,E. and Mazza,F.
Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8
Bioorg Med Chem (31-5-2005) 13, 4740-4749. PubMed Europe PubMed DOI I
Castaneda,F.E., Walia,B., Vijay-Kumar,M., Patel,N.R., Roser,S., Kolachala,V.L., Rojas,M., Wang,L., Oprea,G., Garg,P., Gewirtz,A.T., Roman,J., Merlin,D. and Sitaraman,S.V.
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP
Gastroenterology (2005) 129, 1991-2008. PubMed Europe PubMed DOI
[YEAR:15-3-2005]Dewil,M., Schurmans,C., Starckx,S., Opdenakker,G., Van Den Bosch,L. and Robberecht,W.
Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis
Neuroreport (15-3-2005) 16, 321-324. PubMed Europe PubMed DOI
[YEAR:6-7-2005]Gu,Z., Cui,J., Brown,S., Fridman,R., Mobashery,S., Strongin,A.Y. and Lipton,S.A.
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia
J Neurosci (6-7-2005) 25, 6401-6408. PubMed Europe PubMed DOI I
[YEAR:8-7-2005]Ikejiri,M., Bernardo,M.M., Meroueh,S.O., Brown,S., Chang,M., Fridman,R. and Mobashery,S.
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A
J Org Chem (8-7-2005) 70, 5709-5712. PubMed Europe PubMed DOI I
[YEAR:7-7-2005]Jin,U.H., Lee,J.Y., Kang,S.K., Kim,J.K., Park,W.H., Kim,J.G., Moon,S.K. and Kim,C.H.
A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: Isolation and identification from methanol extract of Euonymus alatus
Life Sci (7-7-2005) 77, 2760-2769. PubMed Europe PubMed DOI I
[YEAR:5-7-2005]Jin,U.H., Chung,T.W., Kang,S.K., Suh,S.J., Kim,J.K., Chung,K.H., Gu,Y.H., Suzuki,I. and Kim,C.H.
Caffeic acid phenyl ester in propolis is a strong inhibitor of matrix metalloproteinase-9 and invasion inhibitor: Isolation and identification
Clin Chim Acta (5-7-2005) 362, 57-64. PubMed Europe PubMed DOI I
[YEAR:29-9-2005]Lee,M., Bernardo,M.M., Meroueh,S.O., Brown,S., Fridman,R. and Mobashery,S.
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors
Org Lett (29-9-2005) 7, 4463-4465. PubMed Europe PubMed DOI I
Ohbayashi,H. and Shimokata,K.
Matrix metalloproteinase-9 and airway remodeling in asthma
Curr Drug Targets Inflamm Allergy (2005) 4, 177-181. PubMed Europe PubMed DOI
[YEAR:28-2-2005]Park,W.H., Kim,S.H. and Kim,C.H.
A new matrix metalloproteinase-9 inhibitor 3,4-dihydroxycinnamic acid (caffeic acid) from methanol extract of Euonymus alatus: isolation and structure determination
Toxicology (28-2-2005) 207, 383-390. PubMed Europe PubMed DOI I
[YEAR:12-7-2005]Xu,X., Chen,Z., Wang,Y., Yamada,Y. and Steffensen,B.
Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2
Biochem J (12-7-2005) 392, 127-134. PubMed Europe PubMed DOI PMC EPMC

2004

Bannikov,G.A., Collier,I.E. and Goldberg,G.I.
Gelatinase B
[ISSN:0-12-079610-4] (2004) 2, 503-511. V
Giraudo,E., Inoue,M. and Hanahan,D.
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
J Clin Invest (2004) 114, 623-633. PubMed Europe PubMed DOI PMC EPMC
Grieu,F., Li,W.Q. and Iacopetta,B.
Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype
Breast Cancer Res Treat (2004) 88, 197-204. PubMed Europe PubMed DOI M
Jadhav,U., Chigurupati,S., Lakka,S.S. and Mohanam,S.
Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells
Int J Oncol (2004) 25, 1407-1414. PubMed Europe PubMed I
Johnson,M.C., Sangrador-Vegas,A., Smith,T.J. and Cairns,M.T.
Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) matrix metalloproteinase-9
Fish Shellfish Immunol (2004) 17, 499-503. PubMed Europe PubMed DOI
Medley,T.L., Cole,T.J., Dart,A.M., Gatzka,C.D. and Kingwell,B.A.
Matrix metalloproteinase-9 genotype influences large artery stiffness through effects on aortic gene and protein expression
Arterioscler Thromb Vasc Biol (2004) 24, 1479-1484. PubMed Europe PubMed DOI M
Tang,J., Liu,J., Zhou,C., Alexander,J.S., Nanda,A., Granger,D.N. and Zhang,J.H.
MMP-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant mice
J Cereb Blood Flow Metab (2004) 24, 1133-1145. PubMed Europe PubMed DOI K

2003

[YEAR:6-3-2003]Bottcher,T., Spreer,A., Azeh,I., Nau,R. and Gerber,J.
Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitis
Neurosci Lett (6-3-2003) 338, 201-204. PubMed Europe PubMed DOI
Chen,E.I., Li,W., Godzik,A., Howard,E.W. and Smith,J.W.
A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9
J Biol Chem (2003) 278, 17158-17163. PubMed Europe PubMed DOI
Descamps,F.J., Van Den Steen,P.E., Martens,E., Ballaux,F., Geboes,K. and Opdenakker,G.
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin
FASEB J (2003) 17, 887-889. PubMed Europe PubMed DOI
[YEAR:3-12-2003]Larsen,P.H., Wells,J.E., Stallcup,W.B., Opdenakker,G. and Yong,V.W.
Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan
J Neurosci (3-12-2003) 23, 11127-11135. PubMed Europe PubMed
Lauer-Fields,J.L., Sritharan,T., Stack,M.S., Nagase,H. and Fields,G.B.
Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9
J Biol Chem (2003) 278, 18140-18145. PubMed Europe PubMed DOI
Nelissen,I., Martens,E., Van Den Steen,P.E., Proost,P., Ronsse,I. and Opdenakker,G.
Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy
Brain (2003) 126, 1371-1381. PubMed Europe PubMed DOI P I
Robinson,S.N., Pisarev,V.M., Chavez,J.M., Singh,R.K. and Talmadge,J.E.
Use of matrix metalloproteinase (MMP)-9 knockout mice demonstrates that MMP-9 activity is not absolutely required for G-CSF or Flt-3 ligand-induced hematopoietic progenitor cell mobilization or engraftment
Stem Cells (2003) 21, 417-427. PubMed Europe PubMed DOI K
Starckx,S., Van Den Steen,P.E., Verbeek,R., van Noort,J.M. and Opdenakker,G.
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alphaB-crystallin and generates a promiscuous T cell epitope
J Neuroimmunol (2003) 141, 47-57. PubMed Europe PubMed DOI
[YEAR:1-6-2003]Underwood,C.K., Min,D., Lyons,J.G. and Hambley,T.W.
The interaction of metal ions and Marimastat with matrix metalloproteinase 9
J Inorg Biochem (1-6-2003) 95, 165-170. PubMed Europe PubMed DOI I
Vaillant,C., Meissirel,C., Mutin,M., Belin,M.F., Lund,L.R. and Thomasset,N.
MMP-9 deficiency affects axonal outgrowth, migration, and apoptosis in the developing cerebellum
Mol Cell Neurosci (2003) 24, 395-408. PubMed Europe PubMed DOI
Van Den Steen,P.E., Husson,S.J., Proost,P., Van Damme,J. and Opdenakker,G.
Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase
Biochem Biophys Res Commun (2003) 310, 889-896. PubMed Europe PubMed DOI
Van Den Steen,P.E., Wuyts,A., Husson,S.J., Proost,P., Van Damme,J. and Opdenakker,G.
Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities
Eur J Biochem (2003) 270, 3739-3749. PubMed Europe PubMed DOI
[YEAR:25-4-2003]Zhao,Y.G., Xiao,A.Z., Newcomer,R.G., Park,H.I., Kang,T., Chung,L.W., Swanson,M.G., Zhau,H.E., Kurhanewicz,J. and Sang,Q.X.
Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells
J Biol Chem (25-4-2003) 278, 15056-15064. PubMed Europe PubMed DOI

2002

Cataldo,D.D., Tournoy,K.G., Vermaelen,K., Munaut,C., Foidart,J.M., Louis,R., Noel,A. and Pauwels,R.A.
Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation
Am J Pathol (2002) 161, 491-498. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:1-11-2002]Cho,A. and Reidy,M.A.
Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury
Circ Res (1-11-2002) 91, 845-851. PubMed Europe PubMed DOI
Dubois,B., Starckx,S., Pagenstecher,A., Oord,J., Arnold,B. and Opdenakker,G.
Gelatinase B deficiency protects against endotoxin shock
Eur J Immunol (2002) 32, 2163-2171. PubMed Europe PubMed DOI
Elkins,P.A., Ho,Y.S., Smith,W.W., Janson,C.A., D'Alessio,K.J., McQueney,M.S., Cummings,M.D. and Romanic,A.M.
Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase
Acta Crystallogr D Biol Crystallogr (2002) 58, 1182-1192. PubMed Europe PubMed DOI S
[YEAR:1-11-2002]Galis,Z.S., Johnson,C., Godin,D., Magid,R., Shipley,J.M., Senior,R.M. and Ivan,E.
Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling
Circ Res (1-11-2002) 91, 852-859. PubMed Europe PubMed DOI
[YEAR:31-5-2002]Heissig,B., Hattori,K., Dias,S., Friedrich,M., Ferris,B., Hackett,N.R., Crystal,R.G., Besmer,P., Lyden,D., Moore,M.A., Werb,Z. and Rafii,S.
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
Cell (31-5-2002) 109, 625-637. PubMed Europe PubMed
[YEAR:16-4-2002]Kaur,K., Zhu,K., Whittemore,M.S., Petersen,R.L., Lichte,A., Tschesche,H. and Pourmotabbed,T.
Identification of the active site of gelatinase B as the structural element sufficient for converting a protein to a metalloprotease
Biochemistry (16-4-2002) 41, 4789-4797. PubMed Europe PubMed DOI I
Kotra,L.P., Zhang,L., Fridman,R., Orlando,R. and Mobashery,S.
N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9
Bioorg Chem (2002) 30, 356-370. PubMed Europe PubMed DOI
[YEAR:14-11-2002]Lakka,S.S., Rajan,M., Gondi,C., Yanamandra,N., Chandrasekar,N., Jasti,S.L., Adachi,Y., Siddique,K., Gujrati,M., Olivero,W., Dinh,D.H., Kouraklis,G., Kyritsis,A.P. and Rao,J.S.
Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion
Oncogene (14-11-2002) 21, 8011-8019. PubMed Europe PubMed DOI
Longo,G.M., Xiong,W., Greiner,T.C., Zhao,Y., Fiotti,N. and Baxter,B.T.
Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
J Clin Invest (2002) 110, 625-632. PubMed Europe PubMed DOI PMC EPMC
[YEAR:27-12-2002]Roeb,E., Schleinkofer,K., Kernebeck,T., Potsch,S., Jansen,B., Behrmann,I., Matern,S. and Grotzinger,J.
The matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist
J Biol Chem (27-12-2002) 277, 50326-50332. PubMed Europe PubMed DOI
[YEAR:24-5-2002]Rowsell,S., Hawtin,P., Minshull,C.A., Jepson,H., Brockbank,S.M., Barratt,D.G., Slater,A.M., McPheat,W.L., Waterson,D., Henney,A.M. and Pauptit,R.A.
Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor
J Mol Biol (24-5-2002) 319, 173-181. PubMed Europe PubMed DOI S I
Van Den Steen,P.E., Dubois,B., Nelissen,I., Rudd,P.M., Dwek,R.A. and Opdenakker,G.
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)
Crit Rev Biochem Mol Biol (2002) 37, 375-536. PubMed Europe PubMed DOI V

2001

[YEAR:1-10-2001]Asahi,M., Wang,X., Mori,T., Sumii,T., Jung,J.C., Moskowitz,M.A., Fini,M.E. and Lo,E.H.
Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
J Neurosci (1-10-2001) 21, 7724-7732. PubMed Europe PubMed K
[YEAR:8-6-2001]Berton,A., Rigot,V., Huet,E., Decarme,M., Eeckhout,Y., Patthy,L., Godeau,G., Hornebeck,W., Bellon,G. and Emonard,H.
Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids
J Biol Chem (8-6-2001) 276, 20458-20465. PubMed Europe PubMed DOI I
[YEAR:15-4-2001]Gonzalez-Gronow,M., Grenett,H.E., Weber,M.R., Gawdi,G. and Pizzo,S.V.
Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells
Biochem J (15-4-2001) 355, 397-407. PubMed Europe PubMed DOI PMC EPMC
Ihara,M., Tomimoto,H., Kinoshita,M., Oh,J., Noda,M., Wakita,H., Akiguchi,I. and Shibasaki,H.
Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter
J Cereb Blood Flow Metab (2001) 21, 828-834. PubMed Europe PubMed DOI
[YEAR:8-6-2001]Kridel,S.J., Chen,E., Kotra,L.P., Howard,E.W., Mobashery,S. and Smith,J.W.
Substrate hydrolysis by matrix metalloproteinase-9
J Biol Chem (8-6-2001) 276, 20572-20578. PubMed Europe PubMed DOI
[YEAR:2-4-2001]Lelongt,B., Bengatta,S., Delauche,M., Lund,L.R., Werb,Z. and Ronco,P.M.
Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity
J Exp Med (2-4-2001) 193, 793-802. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:15-5-2001]Medina,O.P., Soderlund,T., Laakkonen,L.J., Tuominen,E.K., Koivunen,E. and Kinnunen,P.K.
Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro
Cancer Res (15-5-2001) 61, 3978-3985. PubMed Europe PubMed I
[YEAR:23-11-2001]Minematsu,N., Nakamura,H., Tateno,H., Nakajima,T. and Yamaguchi,K.
Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema
Biochem Biophys Res Commun (23-11-2001) 289, 116-119. PubMed Europe PubMed DOI M
Opdenakker,G., Van Den Steen,P.E., Dubois,B., Nelissen,I., Van Coillie,E., Masure,S., Proost,P. and Van Damme,J.
Gelatinase B functions as regulator and effector in leukocyte biology
J Leukoc Biol (2001) 69, 851-859. PubMed Europe PubMed
Papathoma,A.S., Zoumpourlis,V., Balmain,A. and Pintzas,A.
Role of matrix metalloproteinase-9 in progression of mouse skin carcinogenesis
Mol Carcinog (2001) 31, 74-82. PubMed Europe PubMed DOI
[YEAR:27-9-2001]Schroder,J., Henke,A., Wenzel,H., Brandstetter,H., Stammler,H.G., Stammler,A., Pfeiffer,W.D. and Tschesche,H.
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold
J Med Chem (27-9-2001) 44, 3231-3243. PubMed Europe PubMed DOI I
Warner,R.L., Beltran,L., Younkin,E.M., Lewis,C.S., Weiss,S.J., Varani,J. and Johnson,K.J.
Role of stromelysin 1 and gelatinase B in experimental acute lung injury
Am J Respir Cell Mol Biol (2001) 24, 537-544. PubMed Europe PubMed DOI K
[YEAR:27-7-2001]Watanabe,Y., Hirakawa,K., Haruyama,T. and Akaike,T.
Direct production of an activated matrix metalloproteinase-9 (gelatinase B) from mammalian cells
FEBS Lett (27-7-2001) 502, 63-67. PubMed Europe PubMed DOI
Whiteside,E.J., Jackson,M.M., Herington,A.C., Edwards,D.R. and Harvey,M.B.
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos
Biol Reprod (2001) 64, 1331-1337. PubMed Europe PubMed

2000

Andrews,K.L., Betsuyaku,T., Rogers,S., Shipley,J.M., Senior,R.M. and Miner,J.H.
Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome
Am J Pathol (2000) 157, 303-311. PubMed Europe PubMed DOI PMC EPMC
Brown,S., Bernardo,M.M., Li,Z.H., Kotra,L.P., Tanaka,Y., Fridman,R. and Mobashery,S.
Potent and selective mechanism-based inhibition of gelatinases
J Am Chem Soc (2000) 122, 6799-6800. DOI I
Carinato,M.E., Walter,B.E. and Henry,J.J.
Xenopus laevis gelatinase B (Xmmp-9): Development, regeneration, and wound healing
Dev Dyn (2000) 217, 377-387. PubMed Europe PubMed DOI
Fasciglione,G.F., Marini,S., D'Alessio,S., Politi,V. and Coletta,M.
pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B
Biophys J (2000) 79, 2138-2149. PubMed Europe PubMed DOI PMC EPMC
[YEAR:29-12-2000]Hahn-Dantona,E.A., Aimes,R.T. and Quigley,J.P.
The isolation, characterization, and molecular cloning of a 75-kDa gelatinase B-like enzyme, a member of the matrix metalloproteinase (MMP) family. An avian enzyme that is MMP-9-like in its cell expression pattern but diverges from mammalian gelatinase B in sequence and biochemical properties
J Biol Chem (29-12-2000) 275, 40827-40838. PubMed Europe PubMed DOI
[YEAR:3-11-2000]Kleifeld,O., Van Den Steen,P.E., Frenkel,A., Cheng,F., Jiang,H.L., Opdenakker,G. and Sagi,I.
Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils
J Biol Chem (3-11-2000) 275, 34335-34343. PubMed Europe PubMed DOI
[YEAR:26-12-2000]Mattu,T.S., Royle,L., Langridge,J., Wormald,M.R., Van Den Steen,P.E., Van Damme,J., Opdenakker,G., Harvey,D.J., Dwek,R.A. and Rudd,P.M.
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase- HPLC and online tandem mass spectrometry: Implications for the domain organization of the enzyme
Biochemistry (26-12-2000) 39, 15695-15704. PubMed Europe PubMed DOI
[YEAR:15-10-2000]Van Den Steen,P.E., Proost,P., Wuyts,A., Van Damme,J. and Opdenakker,G.
Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact
Blood (15-10-2000) 96, 2673-2681. PubMed Europe PubMed

1999

[YEAR:16-4-1999]Butler,G.S., Apte,S.S., Willenbrock,F. and Murphy,G.
Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions
J Biol Chem (16-4-1999) 274, 10846-10851. PubMed Europe PubMed DOI
Dubois,B., Masure,S., Hurtenbach,U., Paemen,L., Heremans,H., van den Oord,J., Sciot,R., Meinhardt,T., Hammerling,G., Opdenakker,G. and Arnold,B.
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions
J Clin Invest (1999) 104, 1507-1515. PubMed Europe PubMed DOI PMC EPMC K
Itoh,T., Tanioka,M., Matsuda,H., Nishimoto,H., Yoshioka,T., Suzuki,R. and Uehira,M.
Experimental metastasis is suppressed in MMP-9-deficient mice
Clin Exp Metastasis (1999) 17, 177-181. PubMed Europe PubMed DOI K
[YEAR:1-10-1999]Oh,L.Y., Larsen,P.H., Krekoski,C.A., Edwards,D.R., Donovan,F., Werb,Z. and Yong,V.W.
Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes
J Neurosci (1-10-1999) 19, 8464-8475. PubMed Europe PubMed K
[YEAR:30-7-1999]Passi,A., Negrini,D., Albertini,R., Miserocchi,G. and De Luca,G.
The sensitivity of versican from rabbit lung to gelatinase A (MMP-2) and B (MMP-9) and its involvement in the development of hydraulic lung edema
FEBS Lett (30-7-1999) 456, 93-96. PubMed Europe PubMed DOI
Roy,N., Padmanabhan,S., Smith,M., Shi,L., Navre,M. and Das,G.
Expression of human gelatinase B in Pichia pastoris
Protein Expr Purif (1999) 16, 324-330. PubMed Europe PubMed DOI E
Wang,M., Qin,X., Mudgett,J.S., Ferguson,T.A., Senior,R.M. and Welgus,H.G.
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response
Proc Natl Acad Sci U S A (1999) 96, 6885-6889. PubMed Europe PubMed DOI PMC EPMC K

1998

Krumme,D., Wenzel,H. and Tschesche,H.
Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases
FEBS Lett (1998) 436, 209-212. PubMed Europe PubMed DOI I
Lijnen,H.R., Silence,J., Lemmens,G., Frederix,L. and Collen,D.
Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system
Thromb Haemost (1998) 79, 1171-1176. PubMed Europe PubMed
Vu,T.H. and Werb,Z.
Gelatinase B: structure, regulation and function
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1997

Fang,K.C., Raymond,W.W., Blount,J.L. and Caughey,G.H.
Dog mast cell alpha-chymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain
J Biol Chem (1997) 272, 25628-25635. PubMed Europe PubMed DOI
George,H.J., Marchand,P., Murphy,K., Wiswall,B.H., Dowling,R., Giannaras,J., Hollis,G.F., Trzaskos,J.M. and Copeland,R.A.
Recombinant human 92-kDa type IV collagenase/gelatinase from baculovirus-infected insect cells: expression, purification, and characterization
Protein Expr Purif (1997) 10, 154-161. PubMed Europe PubMed DOI E
Knauper,V., Smith,B., Lopez-Otin,C. and Murphy,G.
Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13)
Eur J Biochem (1997) 248, 369-373. PubMed Europe PubMed
Leber,T.M. and Balkwill,F.R.
Zymography: a single-step staining method for quantitation of proteolytic activity on substrate gels
Anal Biochem (1997) 249, 24-28. PubMed Europe PubMed DOI A
Masure,S., Paemen,L., Van Aelst,I., Fiten,P., Proost,P., Billiau,A., Van Damme,J. and Opdenakker,G.
Production and characterization of recombinant active mouse gelatinase B from eukaryotic cells and in vivo effects after intravenous administration
Eur J Biochem (1997) 244, 21-30. PubMed Europe PubMed
[YEAR:14-11-1997]Patterson,B.C. and Sang,Q.A.
Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)
J Biol Chem (14-11-1997) 272, 28823-28825. PubMed Europe PubMed DOI P
Quesada,A.R., Barbacid,M.M., Mira,E., Fernandez-Resa,P., Marquez,G. and Aracil,M.
Evaluation of fluorometric and zymographic methods as activity assays for stromelysins and gelatinases
Clin Exp Metastasis (1997) 15, 26-32. PubMed Europe PubMed DOI A

1995

Backstrom,J.R. and Tokes,Z.A.
The 84-kDa form of human matrix metalloproteinase-9 degrades substance P and gelatin
J Neurochem (1995) 64, 1312-1318. PubMed Europe PubMed
[YEAR:15-6-1995]Fridman,R., Toth,M., Pena,D. and Mobashery,S.
Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)
Cancer Res (15-6-1995) 55, 2548-2555. PubMed Europe PubMed
Itoh,Y. and Nagase,H.
Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase
J Biol Chem (1995) 270, 16518-16521. PubMed Europe PubMed DOI
Murphy,G. and Crabbe,T.
Gelatinases A and B
Methods Enzymol (1995) 248, 470-484. PubMed Europe PubMed DOI V
Okada,A., Santavicca,M. and Basset,P.
The cDNA cloning and expression of the gene encoding rat gelatinase B
Gene (1995) 164, 317-321. PubMed Europe PubMed DOI
[YEAR:6-9-1995]Sang,Q.X., Birkedal-Hansen,H. and Van Wart,H.E.
Proteolytic and non-proteolytic activation of human neutrophil progelatinase B
Biochim Biophys Acta (6-9-1995) 1251, 99-108. PubMed Europe PubMed DOI

1994

Brown,F.K., Brown,P.J., Bickett,D.M., Chambers,C.L., Davies,H.G., Deaton,D.N., Drewry,D., Foley,M., McElroy,A.B., Gregson,M., McGeehan,G.M., Myers,P.L., Norton,D., Salovich,J.M., Schoenen,F.J. and Ward,P.
Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: modification of the P1 and P2' residues
J Med Chem (1994) 37, 674-688. PubMed Europe PubMed I
Diekmann,O. and Tschesche,H.
Degradation of kinins, angiotensins and substance P by polymorphonuclear matrix metalloproteinases MMP 8 and MMP 9
Braz J Med Biol Res (1994) 27, 1865-1876. PubMed Europe PubMed
[YEAR:18-11-1994]Fini,M.E., Bartlett,J.D., Matsubara,M., Rinehart,W.B., Mody,M.K., Girard,M.T. and Rainville,M.
The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription
J Biol Chem (18-11-1994) 269, 28620-28628. PubMed Europe PubMed
[YEAR:29-11-1994]Ochieng,J., Fridman,R., Nangia-Makker,P., Kleiner,D.E., Liotta,L.A., Stetler-Stevenson,W.G. and Raz,A.
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9
Biochemistry (29-11-1994) 33, 14109-14114. PubMed Europe PubMed DOI

1993

[YEAR:15-11-1993]Masure,S., Nys,G., Fiten,P., Van Damme,J. and Opdenakker,G.
Mouse gelatinase B. cDNA cloning, regulation of expression and glycosylation in WEHI-3 macrophages and gene organisation
Eur J Biochem (15-11-1993) 218, 129-141. PubMed Europe PubMed DOI
Tanaka,H., Hojo,K., Yoshida,H., Yoshioka,T. and Sugita,K.
Molecular cloning and expression of the mouse 105-kDa gelatinase cDNA
Biochem Biophys Res Commun (1993) 190, 732-740. PubMed Europe PubMed DOI

1992

[YEAR:15-12-1992]Devarajan,P., Johnston,J.J., Ginsberg,S.S., Van Wart,H.E. and Berliner,N.
Structure and expression of neutrophil gelatinase cDNA. Identity with type IV collagenase from HT1080 cells
J Biol Chem (15-12-1992) 267, 25228-25232. PubMed Europe PubMed
Ogata,Y., Enghild,J.J. and Nagase,H.
Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9
J Biol Chem (1992) 267, 3581-3584. PubMed Europe PubMed

1991

Masure,S., Proost,P., Van Damme,J. and Opdenakker,G.
Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8
Eur J Biochem (1991) 198, 391-398. PubMed Europe PubMed
Opdenakker,G., Masure,S., Proost,P., Billiau,A. and Van Damme,J.
Natural human monocyte gelatinase and its inhibitor
FEBS Lett (1991) 284, 73-78. PubMed Europe PubMed DOI
Woessner,J.F., Jr.
Matrix metalloproteinases and their inhibitors in connective tissue remodeling
FASEB J (1991) 5, 2145-2154. PubMed Europe PubMed

1989

Wilhelm,S.M., Collier,I.E., Marmer,B.L., Eisen,A.Z., Grant,G.A. and Goldberg,G.I.
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages
J Biol Chem (1989) 264, 17213-17221. PubMed Europe PubMed

1987

Hibbs,M.S., Hoidal,J.R. and Kang,A.H.
Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages
J Clin Invest (1987) 80, 1644-1650. PubMed Europe PubMed DOI PMC EPMC

1985

[YEAR:25-2-1985]Hibbs,M.S., Hasty,K.A., Seyer,J.M., Kang,A.H. and Mainardi,C.L.
Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase
J Biol Chem (25-2-1985) 260, 2493-2500. PubMed Europe PubMed