Literature for peptidase M10.003: matrix metallopeptidase-2

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Conde-Tella,S.O., Gerlach,R.F. and Tanus-Santos,J.E.
   Using Zymography to Assess Circulating Matrix Metalloproteinase (MMP)-2 and MMP-9 in Clinical Samples
   Methods Mol Biol2918, 177-186. PubMed  Europe PubMed DOI  L
2. George,J.
   Zymography: A Simple and Powerful Tool for the Assessment of MMP-2 and MMP-9 in Pathological Conditions
   Methods Mol Biol2918, 187-199. PubMed  Europe PubMed DOI  L
3. Sarker,H., Panigrahi,R., Lopez-Campistrous,A., McMullen,T., Reyes,K., Anderson,E., Krishnan,V., Hernandez-Anzaldo,S., Zheng,X.L., Glover,J.N.M., Hardy,E. and Fernandez-Patron,C.
   Apolipoprotein-A1 transports and regulates MMP2 in the blood
   Nat Commun16, 3752-3752. PubMed  Europe PubMed DOI
4. Sun,N., Wang,S., Liu,J., Zhang,P., Chang,Y., Li,H., Zhao,K., Liu,Y., Huang,M., Hu,Y., Lin,Z., Lu,Y., Jiang,G., Chen,W., Huang,C. and Jin,H.
   XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1
   Cell Death Dis16, 205-205. PubMed  Europe PubMed DOI
5. Takatsuka,R., Terashima,M., Ishimura,A., Suzuki,T. and Takino,T.
   Iron regulates MT1-MMP-mediated proMMP-2 activation and cancer cell invasion
   Biochem Biophys Res Commun742, 151124-151124. PubMed  Europe PubMed DOI
6. Veilleux,C., Roy,M.E. and Annabi,B.
   Assessing MMP-2/9 Proteolytic Activity and Activation Status by Zymography in Preclinical and Clinical Tissue Samples
   Methods Mol Biol2918, 165-176. PubMed  Europe PubMed DOI  L
2024
7. Alekhmimi,N., Ramadan,Q., Cialla-May,D., Popp,J., Al-Kattan,K., Alhoshani,A. and Zourob,M.
   In Vivo Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Imaging of MMP-2 in ALI/ARDS in LPS-Treated Mice
   ACS Omega9, 3609-3615. PubMed  Europe PubMed DOI
8. Blascke de Mello,M.M., Neves,V.G.O., Parente,J.M., Pernomian,L., de Oliveira,I.S., Pedersoli,C.A., Awata,W.M.C., Tirapelli,C.R., Arantes,E.C., Tostes,R.C.A., Schulz,R. and Castro,M.M.
   Sarcoplasmic reticulum calcium ATPase (SERCA) proteolysis by matrix metalloproteinase-2 contributes to vascular dysfunction in early hypertension
   Eur J Pharmacol983, 176981-176981. PubMed  Europe PubMed DOI  L
9. Capelli,L., Pedrini,F., Di Pede,A.C., Chamorro-Garcia,A., Bagheri,N., Fortunati,S., Giannetto,M., Mattarozzi,M., Corradini,R., Porchetta,A. and Bertucci,A.
   Synthetic Protein-to-DNA Input Exchange for Protease Activity Detection Using CRISPR-Cas12a
   Anal Chem PubMed  Europe PubMed DOI
10. Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E.
    Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target
    Basic Clin Pharmacol Toxicol134, 727-736. PubMed  Europe PubMed DOI  L
11. Chen,Y., Zhu,D., Zhong,H., Gan,Z., Zong,S., Wang,Z., Cui,Y. and Wang,Y.
    Ultrasensitive Detection of Matrix Metalloproteinase 2 Activity Using a Ratiometric Surface-Enhanced Raman Scattering Nanosensor with a Core-Satellite Structure
    ACS Appl Mater Interfaces16, 4160-4168. PubMed  Europe PubMed DOI
12. Cioates Negut,C., Ilie-Mihai,R.M. and Stefan-van Staden,R.I.
    Determination of Matrix Metalloproteinase 2 in Biological Samples Using a 3D Stochastic Microsensor Based on Graphene Oxide/AuNanoparticles/(Z)-N-(pyridin-4-yl-methyl) Octadec-9-enamide
    Int J Mol Sci25, PubMed  Europe PubMed DOI
13. Gong,Y., Zhang,J., Xi,Y., Jian,D., Zhuo,C., Tang,Q., Zhang,K. and Liao,X.
    Highly sensitive detection of MMP-2 using an electrochemiluminescent biosensor enhanced by ladder-branch hybridization chain reaction
    Mikrochim Acta191, 742-742. PubMed  Europe PubMed DOI
14. Guo,J., Hu,M., Yang,M., Cao,H., Li,H., Zhu,J., Li,S. and Zhang,J.
    Inhibition mechanism of theaflavins on matrix metalloproteinase-2: inhibition kinetics, multispectral analysis, molecular docking and molecular dynamics simulation
    Food Funct PubMed  Europe PubMed DOI
15. Kamarajan,P., Timm,J.C., Goetting-Minesky,M.P., Malone,E.T., Ganther,S., Radaic,A., Tafolla,C., Fenno,J.C. and Kapila,Y.L.
    Purification of Native Dentilisin Complex from Treponema denticola by Preparative Continuous Polyacrylamide Gel Electrophoresis and Functional Analysis by Gelatin Zymography
    Bio Protoc14, e4970-e4970. PubMed  Europe PubMed DOI  L
16. Morokuma,J., Garriz,A., Toribio,D., Pagni,S. and Zoukhri,D.
    Interleukin-1beta activates matrix metalloproteinase-2 to alter lacrimal gland myoepithelial cell structure and function
    Front Ophthalmol (Lausanne)4, 1415002-1415002. PubMed  Europe PubMed DOI
17. Shi,Z., Yan,J., Zhao,M., Li,S., She,T. and Qian,X.
    Co-encapsulation of granzyme B and perforin in nanocapsules for tumour therapy: biomimicking immune cells
    J Control Release369, 658-667. PubMed  Europe PubMed DOI
2023
18. Baidya,S.K., Banerjee,S., Ghosh,B., Jha,T. and Adhikari,N.
    Assessing structural insights into in-house arylsulfonyl L-(+) glutamine MMP-2 inhibitors as promising anticancer agents through structure-based computational modelling approaches
    SAR QSAR Environ Res34, 805-830. PubMed  Europe PubMed DOI
19. Bassiouni,W., Valencia,R., Mahmud,Z., Seubert,J.M. and Schulz,R.
    Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia-reperfusion injury
    Basic Res Cardiol118, 29-29. PubMed  Europe PubMed DOI  L
20. Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
    Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
    Res Sq PubMed  Europe PubMed DOI
21. Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N.
    Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
    Sci Rep13, 5186-5186. PubMed  Europe PubMed DOI
22. Ishaq,T., Loid,P., Ishaq,H.A., Seo,G.H., Makitie,O. and Naz,S.
    Clinical, radiographic and molecular characterization of two unrelated families with multicentric osteolysis, nodulosis, and arthropathy
    BMC Musculoskelet Disord24, 735-735. PubMed  Europe PubMed DOI
23. Kowalczyk,A., Nisiewicz,M.K., Bamburowicz-Klimkowska,M., Kasprzak,A., Ruzycka-Ayoush,M., Koszytkowska-Stawinska,M. and Nowicka,A.M.
    Effective voltammetric tool for simultaneous detection of MMP-1, MMP-2, and MMP-9; important non-small cell lung cancer biomarkers
    Biosens Bioelectron229, 115212-115212. PubMed  Europe PubMed DOI
24. Li,P.H., Liao,C.H., Huang,W.C., Chang,W.S., Wu,H.C., Hsu,S.W., Chen,K.Y., Wang,Z.H., Hsia,T.C., Bau,D.T. and Tsai,C.W.
    Association of Matrix Metalloproteinase-2 Genotypes With Prostate Cancer Risk
    Anticancer Res43, 343-349. PubMed  Europe PubMed DOI
25. Luo,F.F., Wang,J., Zhang,Z.F., Lin,S.T., Huang,T.J., Liu,B.Q., Fan,M.L., Peng,L.X., Zheng,S.T., Yang,C.F. and Huang,B.J.
    SPI1-Mediated Upregulation of the CST1 Gene as an Independent Poor Prognostic Factor Accelerates Metastasis in Esophageal Squamous Cell Carcinoma (ESCC) by Interacting with MMP2
    Front Biosci (Landmark Ed)28, 212-212. PubMed  Europe PubMed DOI
26. Reddy,R.A., Sai Varshini,M. and Kumar,R.S.
    Matrix Metalloproteinase-2 (MMP-2): As an Essential Factor in Cancer Progression
    Recent Pat Anticancer Drug Discov20, 26-44. PubMed  Europe PubMed DOI  V
27. Ribeiro Vitorino,T., Ferraz do Prado,A., Bruno de Assis Cau,S. and Rizzi,E.
    MMP-2 and its implications on cardiac function and structure: Interplay with inflammation in hypertension
    Biochem Pharmacol215, 115684-115684. PubMed  Europe PubMed DOI  V
28. Samah,N., Ugusman,A., Hamid,A.A., Sulaiman,N. and Aminuddin,A.
    Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease
    Mediators Inflamm2023, 9715114-9715114. PubMed  Europe PubMed DOI  V
29. Sangwan,P., Quasimi,H., Sharma,J.G., Habib,M.A. and Alam,M.I.
    Role of Oxidative Stress and Genetic Polymorphism of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in COPD
    Chronic Obstr Pulm Dis PubMed  Europe PubMed DOI  V
30. Takeuchi,T., Nomura,Y., Tamita,T., Nishikawa,R., Kakinuma,H., Kojima,N., Hitaka,K., Tamura,Y., Kamitani,M., Mima,M., Nozoe,A. and Hayashi,M.
    Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold
    J Med Chem66, 822-836. PubMed  Europe PubMed DOI  I
31. Yao,T., Chen,J., Kong,L., Liu,Y., Yuan,R. and Chai,Y.
    Efficient Three-Dimensional DNA Nanomachine Guided by a Robust Tetrahedral DNA Nanoarray Structure for the Rapid and Ultrasensitive Electrochemical Detection of Matrix Metalloproteinase 2
    Anal Chem95, 13211-13219. PubMed  Europe PubMed DOI
32. Zhang,Y.N., Liu,J.J., Zhang,W., Qin,H.Y., Wang,L.T., Chen,Y.Y., Yuan,L., Yang,F., Cao,R.Y. and Wang,X.J.
    Expression, purification and refolding of pro-MMP-2 from inclusion bodies of E. coli
    Protein Expr Purif208-209, 106278-106278. PubMed  Europe PubMed DOI  L
33. Zhu,X., Song,Y., Wang,X., Zhou,Y., Chai,Y. and Yuan,R.
    Copper nanoclusters electrochemiluminescence with tunable near-infrared emission wavelength for ultrasensitive detection of matrix metalloproteinase-2
    Biosens Bioelectron238, 115580-115580. PubMed  Europe PubMed DOI
2022
34. Maybee,D.V., Ink,N.L. and Ali,M.A.M.
    Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu
    Int J Mol Sci23, PubMed  Europe PubMed DOI  V
35. Morales-Hernandez,F.V., Bautista-Bautista,G., Acuna-Gonzalez,R.J., Vazquez-Cardenas,P., Lopez-Canales,J.S., Lozano-Cuenca,J., Osorio-Caballero,M. and Flores-Herrera,H.
    Differential proMMP-2 and proMMP-9 secretion in human pre-implantation embryos at day 5 of development
    Acta Biochim Pol69, 683-689. PubMed  Europe PubMed DOI  L
36. Sanyal,S., Amin,S.A., Banerjee,P., Gayen,S. and Jha,T.
    A review of MMP-2 structures and binding mode analysis of its inhibitors to strategize structure-based drug design
    Bioorg Med Chem74, 117044-117044. PubMed  Europe PubMed DOI
2021
37. Ali,M.A.M., Garcia-Vilas,J.A., Cromwell,C.R., Hubbard,B.P., Hendzel,M.J. and Schulz,R.
    Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones
    FEBS J PubMed  Europe PubMed DOI
38. Anuar,N.N.M., Zulkafali,N.I.N. and Ugusman,A.
    Modulation of Matrix Metalloproteinases by Plant-Derived Products
    Curr Cancer Drug Targets21, 91-106. PubMed  Europe PubMed DOI  V  I
39. Bassiouni,W., Ali,M.A.M. and Schulz,R.
    Multifunctional intracellular matrix metalloproteinases: implications in disease
    FEBS J288, 7162-7182. PubMed  Europe PubMed DOI  V
40. Bourgi,R., Daood,U., Bijle,M.N., Fawzy,A., Ghaleb,M. and Hardan,L.
    Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry
    Polymers (Basel)13, PubMed  Europe PubMed DOI
41. Buttacavoli,M., Di Cara,G., Roz,E., Pucci-Minafra,I., Feo,S. and Cancemi,P.
    Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9
    Int J Mol Sci22, PubMed  Europe PubMed DOI  L
42. Fang,Y., Li,Y., Li,Y., He,R., Zhang,Y., Zhang,X., Liu,Y. and Ju,H.
    In Situ Protease Secretion Visualization and Metastatic Lymph Nodes Imaging via a Cell Membrane-Anchored Upconversion Nanoprobe
    Anal Chem93, 7258-7265. PubMed  Europe PubMed DOI
43. Goossens,J.F., Goossens,L. and Bailly,C.
    Hinokiflavone and Related C-O-C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action
    Nat Prod Bioprospect PubMed  Europe PubMed DOI  V  I
44. Harwood,S.L., Nielsen,N.S., Diep,K., Jensen,K.T., Nielsen,P.K., Yamamoto,K. and Enghild,J.J.
    Development of selective protease inhibitors via engineering of the bait region of human alpha2-macroglobulin
    J Biol Chem297, 100879-100879. PubMed  Europe PubMed DOI
45. Lenci,E., Angeli,A., Calugi,L., Innocenti,R., Carta,F., Supuran,C.T. and Trabocchi,A.
    Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II
    Eur J Med Chem214, 113260-113260. PubMed  Europe PubMed DOI
46. Li,X., Jin,L. and Tan,Y.
    Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis (Review)
    Mol Med Rep23, PubMed  Europe PubMed DOI
47. Liu,C.F., Xia,Y., To,J., Chan,N.Y., Hu,S., Liew,H.T., Balamkundu,S., Zhang,X., Lescar,J., Bhattacharjya,S. and Tam,J.P.
    Ngamma-Hydroxyasparagine: a Multifunctional Unnatural Amino Acid That is a Good P1 Substrate of Asparaginyl Peptide Ligases
    Angew Chem Int Ed Engl PubMed  Europe PubMed DOI  I
48. Liu,F., Chen,R., Song,W., Li,L., Lei,C. and Nie,Z.
    Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers
    Anal Chem93, 3517-3525. PubMed  Europe PubMed DOI
49. Nissi,R., Santala,M. and Talvensaari-Mattila,A.
    The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study
    BMC Res Notes14, 31-31. PubMed  Europe PubMed DOI
50. Rocchi,D., Blazquez-Barbadillo,C., Agamennone,M., Laghezza,A., Tortorella,P., Vicente-Zurdo,D., Rosales-Conrado,N., Moyano,P., Pino,J.D., Gonzalez,J.F. and Menendez,J.C.
    Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity
    Eur J Med Chem210, 113061-113061. PubMed  Europe PubMed DOI  I
51. Tarki,S.E., Far,I.S., Aminimoghaddam,S., Fooladi,B., Sarhangi,N., Farahani,M.S., Klashami,Z.N., Hamidi,A.K. and Amoli,M.M.
    Investigating the association of matrix metalloproteinase-2 gene variants with endometriosis in an Iranian population
    Eur J Obstet Gynecol Reprod Biol258, 353-357. PubMed  Europe PubMed DOI
52. Yuan,X., Bian,X., Wei,W., Bao,Q., Liu,P. and Jiang,W.
    miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2
    Genet Mol Biol44, e20200124-e20200124. PubMed  Europe PubMed DOI
2020
53. Amaral,A., Fernandes,C., Morazzo,S., Rebordao,M.R., Szostek-Mioduchowska,A., Lukasik,K., Gawronska-Kozak,B., Telo da Gama,L., Skarzynski,D.J. and Ferreira-Dias,G.
    The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare
    Front Vet Sci7, 582211-582211. PubMed  Europe PubMed DOI
54. Azevedo Martins,J.M., Rabelo-Santos,S.H., do Amaral Westin,M.C. and Zeferino,L.C.
    Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis
    BMC Cancer20, 660-660. PubMed  Europe PubMed DOI
55. Bai,X., Bai,G., Tang,L., Liu,L., Li,Y. and Jiang,W.
    Changes in MMP-2, MMP-9, inflammation, blood coagulation and intestinal mucosal permeability in patients with active ulcerative colitis
    Exp Ther Med20, 269-274. PubMed  Europe PubMed DOI
56. Baidya,S.K., Amin,S.A. and Jha,T.
    Outline of gelatinase inhibitors as anti-cancer agents: A patent mini-review for 2010-present
    Eur J Med Chem113044-113044. PubMed  Europe PubMed DOI  V
57. Bakshi,J., Goyal,A.K., Singh,V., Sannigrahi,M. and Khullar,M.
    Stage-specific expression analysis ofMMP-2 & MMP-9 in laryngeal carcinoma
    J Cancer Res Ther16, 517-520. PubMed  Europe PubMed DOI
58. Barbe,A.M., Berbets,A.M., Davydenko,I.S., Koval,H.D., Yuzko,V.O. and Yuzko,O.M.
    Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis
    J Med Life13, 314-320. PubMed  Europe PubMed DOI
59. Becker,D.P., Lutz,M.R., Flieger,S., Colorina,A., Wozny,J. and Hosmane,N.S.
    Carborane-containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron Capture Therapy (BNCT)
    ChemMedChem PubMed  Europe PubMed DOI  I
60. Bollmann,M., Pinno,K., Ehnold,L.I., Martens,N., Martson,A., Pap,T., Starke,C., Lohmann,C.H. and Bertrand,J.
    MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity
    Osteoarthritis Cartilage PubMed  Europe PubMed DOI  K
61. Carrilho,M.R., Scaffa,P., Oliveira,V., Tjaderhane,L., Tersariol,I.L., Pashley,D.H., Tay,F. and Nascimento,F.D.
    Insights into cathepsin-B activity in mature dentin matrix
    Arch Oral Biol117, 104830-104830. PubMed  Europe PubMed DOI
62. Cheeran,V. and Munuswamy-Ramanujam,G.
    Sesquiterpene lactone Zaluzanin D alters MMP-9 promoter methylation in differentiated THP-1 monocytic cells and down regulates inflammatory cytokines IL-1beta and TNF-alpha
    Int Immunopharmacol87, 106803-106803. PubMed  Europe PubMed DOI
63. Chen,Z., Zhang,F., Zhang,S. and Ma,L.
    The down-regulation of SNCG inhibits the proliferation and invasiveness of human bladder cancer cell line 5637 and suppresses the expression of MMP-2/9
    Int J Clin Exp Pathol13, 1873-1879. PubMed  Europe PubMed  K
64. de Figueiredo,F.A.T., Azevedo,J.P., Lara,M.G., Meschiari,C.A., Issa,J.P.M., Gerlach,R.F. and Lamano,T.C.L.
    Recombinant human MMP-2 associated with monoolein improves bone repair
    Bratisl Lek Listy121, 571-579. PubMed  Europe PubMed DOI
65. Dofara,S.G., Chang,S.L. and Diorio,C.
    Gene Polymorphisms and Circulating Levels of MMP-2 and MMP-9: A Review of Their Role in Breast Cancer Risk
    Anticancer Res40, 3619-3631. PubMed  Europe PubMed DOI
66. Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y.
    USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer
    Onco Targets Ther13, 8495-8510. PubMed  Europe PubMed DOI  L
67. Drishya,G., Nambiar,J., Shaji,S.K., Vanuopadath,M., Achuthan,A., Kumar,A., Alias,A., Sherif,A., Joseph,C., Divya,P., Kumar,D.S., Bose,C., Nair,S.V., Sudarslal,S., Kumar,G.B., Lakshmi,S. and Nair,B.G.
    RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata
    J Biosci45, PubMed  Europe PubMed
68. El-Hussieny,M., Mohammed,E.M., Zenhom,N.M., Refaie,M.M., Okasha,A.M. and Tawab,M.A.E.
    Possible Role of TGF-beta1, MMP-2, E-CAD, beta-Catenin and Antioxidants in Pathogenesis of Placenta Accreta
    Fetal Pediatr Pathol1-11. PubMed  Europe PubMed DOI
69. Gou,X., Xue,Y., Zheng,H., Yang,G., Chen,S., Chen,Z. and Yuan,G.
    Gelatinases Cleave Dentin Sialoprotein Intracellularly
    Front Physiol11, 686-686. PubMed  Europe PubMed DOI  L
70. Hazzaa,H.H., El Shiekh,M.A.M., Abdelgawad,N., Gouda,O.M. and Kamal,N.M.
    Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study
    J Oral Biol Craniofac Res10, 747-752. PubMed  Europe PubMed DOI
71. Huang,C.C., Wang,P.H., Lu,Y.T., Yang,J.S., Yang,S.F., Ho,Y.T., Lin,C.W. and Hsin,C.H.
    Morusin Suppresses Cancer Cell Invasion and MMP-2 Expression through ERK Signaling in Human Nasopharyngeal Carcinoma
    Molecules25, PubMed  Europe PubMed DOI
72. Ji,J.J., Qian,L.L., Zhu,Y., Wu,Y.P., Guo,J.Q., Ma,G.S. and Yao,Y.Y.
    Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway
    Cell Signal75, 109745-109745. PubMed  Europe PubMed DOI
73. Kaczorowska,A., Miekus,N., Stefanowicz,J. and Adamkiewicz-Drozynska,E.
    Selected Matrix Metalloproteinases (MMP-2, MMP-7) and Their Inhibitor (TIMP-2) in Adult and Pediatric Cancer
    Diagnostics (Basel)10, PubMed  Europe PubMed DOI  V
74. Ke,J.Y., Yang,J., Li,J., Xu,Z., Li,M.Q. and Zhu,Z.L.
    Baicalein inhibits FURIN-MT1-MMP-mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1
    Am J Reprod Immunole13344-e13344. PubMed  Europe PubMed DOI
75. Kensara,A., Hefni,E., Williams,M.A., Saito,H., Mongodin,E. and Masri,R.
    Microbiological Profile and Human Immune Response Associated with Peri-Implantitis: A Systematic Review
    J Prosthodont PubMed  Europe PubMed DOI  V
76. Kiani,A., Kamankesh,M., Vaisi-Raygani,A., Moradi,M.R., Tanhapour,M., Rahimi,Z., Elahi-Rad,S., Bahrehmand,F., Aliyari,M., Aghaz,F., Mozafari,H., Rezvani,N., Haghnazari,L. and Pourmotabbed,T.
    Activities and polymorphisms of MMP-2 and MMP-9, smoking, diabetes and risk of prostate cancer
    Mol Biol Rep PubMed  Europe PubMed DOI
77. Kim,J. and Kim,M.M.
    Effect of Lapachol on the Inhibition of Matrix Metalloproteinase Related to the Invasion of Human Fibrosarcoma Cells
    Curr Mol Pharmacol PubMed  Europe PubMed DOI
78. Lee,H., Kim,S.J., Shin,H. and Kim,Y.P.
    Collagen-immobilized extracellular FRET reporter for visualizing protease activity secreted by living cells
    ACS Sens5, 655-664. PubMed  Europe PubMed DOI  L
79. Lenci,E., Contini,A. and Trabocchi,A.
    Discovery of a d-pro-lys peptidomimetic inhibitor of MMP9: Addressing the gelatinase selectivity beyond S1' subsite
    Bioorg Med Chem Lett30, 127467-127467. PubMed  Europe PubMed DOI
80. Li,H., Ma,R.Q., Cheng,H.Y., Ye,X., Zhu,H.L. and Chang,X.H.
    Fibrinogen alpha chain (FGA) promotes the migration and invasion of human endometrial stromal cells in endometriosis through FAK/AKT/MMP-2 pathwaydagger
    Biol Reprod PubMed  Europe PubMed DOI
81. Luo,W., Yu,Y., Wang,H., Liu,K., Wang,Y., Huang,M., Xuan,C., Li,Y. and Qi,J.
    Up-regulation of MMP-2 by histone H3K9 beta-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat
    Acta Diabetol PubMed  Europe PubMed DOI
82. Malik,A., Pal,R. and Gupta,S.K.
    EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression
    Sci Rep10, 12274-12274. PubMed  Europe PubMed DOI
83. Miao,R., Dong,X., Gong,J., Wang,Y., Guo,X., Li,Y., Liu,M., Wan,J., Li,J., Yang,S., Wang,W., Kuang,T., Zhong,J., Zhai,Z. and Yang,Y.
    hsa-miR-106b-5p participates in the development of chronic thromboembolic pulmonary hypertension via targeting matrix metalloproteinase 2
    Pulm Circ10, 2045894020928300-2045894020928300. PubMed  Europe PubMed DOI
84. Morales-Vasquez,F., Castillo-Sanchez,R., Gomora,M.J., Almaraz,M.A., Pedernera,E., Perez-Montiel,D., Rendon,E., Lopez-Basave,H.N., Roman-Basaure,E., Cuevas-Covarrubias,S., Maldonado-Cubas,J., Villa,A. and Mendez,C.
    Expression of metalloproteinases MMP-2 and MMP-9 is associated to the presence of androgen receptor in epithelial ovarian tumors
    J Ovarian Res13, 86-86. PubMed  Europe PubMed DOI
85. Nie,S., Lou,L., Wang,J., Cui,J., Wu,W., Zhang,Q., Liu,Y., Su,L., Chang,Y., Guo,W., Shen,H., Xing,L. and Li,Y.
    Expression, association with clinicopathological features and prognostic potential of CEP55, p-Akt, FoxM1 and MMP-2 in astrocytoma
    Oncol Lett20, 1685-1694. PubMed  Europe PubMed DOI
86. Nogueira,M.E., Sousa Neto,I.V., Motta-Santos,D., Cantuaria,A.P.C., Lima,S.M.F., Rezende,T.M.B., Santana,H.A.P., Petriz,B.A., Marqueti,R.C. and Almeida,J.A.
    High-protein diet associated with resistance training reduces cardiac TNF-alpha levels and up-regulates MMP-2 activity in rats
    Arch Physiol Biochem1-7. PubMed  Europe PubMed DOI
87. Olsman,M., Sereti,V., Andreassen,K., Snipstad,S., van Wamel,A., Eliasen,R., Berg,S., Urquhart,A.J., Andresen,T.L. and Davies,C.L.
    Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes
    J Control Release325, 121-134. PubMed  Europe PubMed DOI
88. Omar,A.M., Bajorath,J., Ihmaid,S., Mohamed,H.M., El-Agrody,A.M., Mora,A., El-Araby,M.E. and Ahmed,H.E.A.
    Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects
    Bioorg Chem101, 103992-103992. PubMed  Europe PubMed DOI  I
89. Qiao,Y., Zhan,C., Wang,C., Shi,X., Yang,J., He,X., Ji,E., Yu,Z., Yan,C. and Wu,H.
    MMP-2 sensitive poly(malic acid) micelles stabilized by pi-pi stacking enable high drug loading capacity
    J Mater Chem B8, 8527-8535. PubMed  Europe PubMed DOI
90. Singh,M.P., Sharma,C. and Kang,S.C.
    Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling
    Int Immunopharmacol90, 107234-107234. PubMed  Europe PubMed DOI
91. Song,X., Yang,W., Wu,C., Han,Y. and Lu,Y.
    USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling
    Oncol Lett20, 2897-2905. PubMed  Europe PubMed DOI  K
92. Tjahajawati,S., Zulhazmi,A., Cahyanto,A., Mariam,M.S., Djustiana,N., Aripin,D., Usri,K. and Widyaputra,S.S.
    Matrix levels of metalloproteinase-2 (MMP-2) and toxicity evaluation of carbonate apatite-based endodontic sealer in rat subcutaneous implantation
    Heliyon6, e04330-e04330. PubMed  Europe PubMed DOI
93. Vira,H.J., Pradhan,V.D., Umare,V.D., Chaudhary,A.K., Rajadhyksha,A.G., Nadkar,M.Y., Ghosh,K. and Nadkarni,A.H.
    Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients
    Neth J Med78, 261-268. PubMed  Europe PubMed
94. Voitiv,Y., Usenko,O., Dosenko,V., Dyadyk,O. and Dzhemiliev,A.
    ANALYSIS OF POLYMORPHISM OF MATRIX METALLOPROTEINASE-2 (C-1306
    Georgian Med News7-12. PubMed  Europe PubMed
95. Wang,H., Huang,L., Wu,L., Lan,J., Feng,X., Li,P. and Peng,Y.
    The MMP-2/TIMP-2 system in Alzheimer disease
    CNS Neurol Disord Drug Targets19, 402-416. PubMed  Europe PubMed DOI  V
96. Wu,W.C., Lee,W.J., Lee,T.H., Chen,S.C. and Chen,C.Y.
    Do different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2, -7, and -9 among patients with type 2 diabetes mellitus?
    World J Diabetes11, 252-260. PubMed  Europe PubMed DOI
97. Yang,B., Zhang,D., Qian,J. and Cheng,Y.
    Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system
    Mol Cell Biochem474, 199-208. PubMed  Europe PubMed DOI
98. Yuan,J., Zhang,G., Li,X., Ma,Q., Cheng,W., Wang,W., Zhang,B., Hu,T. and Song,G.
    Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway
    Int J Mol Sci21, PubMed  Europe PubMed DOI  K
99. Yue,Y., Hsiao,Y.W. and Zhou,J.B.
    Association between MMP/TIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients
    Biomed Res Int2020, 2961742-2961742. PubMed  Europe PubMed DOI
100. Zhang,L., Cui,Y., Yang,Y., Wei,J., Liu,W., Cai,L., Wang,L., Zhang,D., Xie,J. and Cheng,L.
     The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells
     Arch Oral Biol122, 104991-104991. PubMed  Europe PubMed DOI  L
101. Zhang,Y., Liu,H., Chen,Z., Yu,M., Li,J., Dong,H., Li,N., Ding,X., Ge,Y., Liu,C., Ma,T. and Gui,B.
     TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice
     Neurochem Int140, 104818-104818. PubMed  Europe PubMed DOI
102. Zhao,F., Wu,H., Reinach,P.S., Wu,Y., Zhai,Y., Lei,Y., Ma,L., Su,Y., Chen,Y., Li,F., Liu,X., Srinivasalu,N., Qu,J. and Zhou,X.
     Up-Regulation of Matrix Metalloproteinase-2 by Scleral Monocyte-Derived Macrophages Contributes to Myopia Development
     Am J Pathol190, 1888-1908. PubMed  Europe PubMed DOI
103. Zhou,Y. and He,C.
     Functional expression and purification of the untagged C-terminal domain of MMP-2 from Escherichia coli inclusion bodies
     Protein Expr Purif176, 105726-105726. PubMed  Europe PubMed DOI
2019
104. Abu Bakar,A.R., Ripen,A.M., Merican,A.F. and Mohamad,S.B.
     Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
     Nat Prod Res33, 1765-1768. PubMed  Europe PubMed DOI  I
105. Bai,P., Lyu,L., Yu,T., Zuo,C., Fu,J., He,Y., Wan,Q., Wan,N., Jia,D. and Lyu,A.
     Macrophage-derived legumain promotes pulmonary hypertension by activating the MMP (matrix metalloproteinase)-2/TGF (transforming growth factor)-beta1 signaling
     Arterioscler Thromb Vasc Biol39, e130-e130. PubMed  Europe PubMed DOI
106. Bertran,A., Khomiak,D., Konopka,A., Rejmak,E., Bulska,E., Seco,J., Kaczmarek,L., Tarrago,T. and Prades,R.
     Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors
     Bioorg Chem103365-103365. PubMed  Europe PubMed DOI  I
107. Chan,B.Y.H., Roczkowsky,A., Cho,W.J., Poirier,M., Lee,T.Y.T., Mahmud,Z. and Schulz,R.
     Junctophilin-2 is a target of matrix metalloproteinase-2 in myocardial ischemia-reperfusion injury
     Basic Res Cardiol114, 42-42. PubMed  Europe PubMed DOI
108. Cook,R., Sarker,H. and Fernandez-Patron,C.
     Pathologies of matrix metalloproteinase-2 underactivity: a perspective on a neglected condition
     Can J Physiol Pharmacol97, 486-492. PubMed  Europe PubMed DOI  K
109. Fallata,A.M., Wyatt,R.A., Levesque,J.M., Dufour,A., Overall,C.M. and Crawford,B.D.
     Intracellular localization in zebrafish muscle and conserved sequence features suggest roles for gelatinase A moonlighting in sarcomere maintenance
     Biomedicines7, PubMed  Europe PubMed DOI
110. Hannocks,M.J., Zhang,X., Gerwien,H., Chashchina,A., Burmeister,M., Korpos,E., Song,J. and Sorokin,L.
     The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes
     Matrix Biol75-76, 102-113. PubMed  Europe PubMed DOI
111. Kanda,H., Shimamura,R., Koizumi-Kitajima,M. and Okano,H.
     Degradation of extracellular matrix by matrix metalloproteinase 2 is essential for the establishment of the blood-brain barrier in Drosophila
     iScience16, 218-229. PubMed  Europe PubMed DOI
112. Laghezza,A., Luisi,G., Caradonna,A., Di Pizio,A., Piemontese,L., Loiodice,F., Agamennone,M. and Tortorella,P.
     Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors
     Bioorg Med Chem115257-115257. PubMed  Europe PubMed DOI  I
113. Lian,Y.Y., He,H.H., Zhang,C.Z., Li,X.C. and Chen,Y.H.
     Functional characterization of a matrix metalloproteinase 2 gene in Litopenaeus vannamei
     Fish Shellfish Immunol84, 404-413. PubMed  Europe PubMed DOI
114. Lyu,Y., Xiao,Q., Yin,L., Yang,L. and He,W.
     Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis
     Signal Transduct Target Ther4, 26-26. PubMed  Europe PubMed DOI  I
115. Marturano,A., Hendrickx,M.L.V., Falcinelli,E., Sebastiano,M., Guglielmini,G., Hassanzadeh-Ghassabeh,G., Muyldermans,S., Declerck,P.J. and Gresele,P.
     Development of anti-matrix metalloproteinase-2 (MMP-2) nanobodies as potential therapeutic and diagnostic tools
     Nanomedicine24, 102103-102103. PubMed  Europe PubMed DOI
116. Sarker,H., Hardy,E., Haimour,A., Maksymowych,W.P., Botto,L.D. and Fernandez-Patron,C.
     Identification of fibrinogen as a natural inhibitor of MMP-2
     Sci Rep9, 4340-4340. PubMed  Europe PubMed DOI
117. Wang,H., Ma,Z. and Han,H.
     A novel impedance enhancer for amperometric biosensor based ultrasensitive detection of matrix metalloproteinase-2
     Bioelectrochemistry130, 107324-107324. PubMed  Europe PubMed DOI  A
118. Yin,L., Sun,H., Zhang,H., He,L., Qiu,L., Lin,J., Xia,H., Zhang,Y., Ji,S., Shi,H. and Gao,M.
     Quantitatively visualizing tumor-related protease activity in vivo using a ratiometric photoacoustic probe
     J Am Chem Soc141, 3265-3273. PubMed  Europe PubMed DOI  L
119. Yin,L., Sun,H., Zhao,M., Wang,A., Qiu,S., Gao,Y., Ding,J., Ji,S.J., Shi,H. and Gao,M.
     Rational design and synthesis of a metalloproteinase-activatable probe for dual-modality imaging of metastatic lymph nodes in vivo
     J Org Chem84, 6126-6133. PubMed  Europe PubMed DOI  L
2018
120. Bencsik,P., Kupai,K., Gorbe,A., Kenyeres,E., Varga,Z.V., Paloczi,J., Gaspar,R., Kovacs,L., Weber,L., Takacs,F., Hajdu,I., Fabo,G., Cseh,S., Barna,L., Csont,T., Csonka,C., Dorman,G. and Ferdinandy,P.
     Development of matrix metalloproteinase-2 inhibitors for cardioprotection
     Front Pharmacol9, 296-296. PubMed  Europe PubMed DOI  I
121. Beutel,B., Song,J., Konken,C.P., Korpos,E., Schinor,B., Gerwien,H., Vidyadharan,R., Burmeister,M., Li,L., Haufe,G. and Sorokin,L.
     New in vivo compatible matrix metalloproteinase (MMP)-2 and MMP-9 inhibitors
     Bioconjug Chem29, 3715-3725. PubMed  Europe PubMed DOI  I
122. Cao,S., Li,Z., Zhao,J., Chen,M. and Ma,N.
     Rational engineering a multichannel upconversion sensor for multiplex detection of matrix metalloproteinase activities
     ACS Sens3, 1522-1530. PubMed  Europe PubMed DOI  L
123. Cowell,S., Carroll,L., Lavdas,I., Aboagye,E.O. and Vilar,R.
     Towards an MMP-2-activated molecular agent for cancer imaging
     Dalton Trans47, 1530-1534. PubMed  Europe PubMed DOI  L
124. Gioia,M., Fasciglione,G.F., Sbardella,D., Sciandra,F., Casella,M., Camerini,S., Crescenzi,M., Gori,A., Tarantino,U., Cozza,P., Brancaccio,A., Coletta,M. and Bozzi,M.
     The enzymatic processing of alpha-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site
     PLoS ONE13, e0192651-e0192651. PubMed  Europe PubMed DOI
125. Jha,T., Adhikari,N., Saha,A. and Amin,S.A.
     Multiple molecular modelling studies on some derivatives and analogues of glutamic acid as matrix metalloproteinase-2 inhibitors
     SAR QSAR Environ Res29, 43-68. PubMed  Europe PubMed DOI  I
126. Kim,I.Y., Kim,S.S., Lee,H.W., Bae,S.S., Ha,H.K., Jung,E.S., Lee,M.Y., Han,M., Rhee,H., Seong,E.Y., Lee,D.W., Lee,S.B., Lovett,D.H. and Song,S.H.
     The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus
     BMC Nephrol19, 248-248. PubMed  Europe PubMed DOI
127. Kuwabara,Y., Kobayashi,T., D'Alessandro-Gabazza,C.N., Toda,M., Yasuma,T., Nishihama,K., Takeshita,A., Fujimoto,H., Nagao,M., Fujisawa,T. and Gabazza,E.C.
     Role of matrix metalloproteinase-2 in eosinophil-mediated airway remodeling
     Front Immunol9, 2163-2163. PubMed  Europe PubMed DOI
128. Li,X.
     Gelatinase inhibitors: a patent review (2011-2017)
     Expert Opin Ther Pat28, 31-46. PubMed  Europe PubMed DOI  V  I
129. Liu,C., Li,S., Gu,Y., Xiong,H., Wong,W.T. and Sun,L.
     Multispectral photoacoustic imaging of tumor protease activity with a gold nanocage-based activatable probe
     Mol Imaging Biol20, 919-929. PubMed  Europe PubMed DOI  A  L
130. Liu,J.W. and Chen,D.Q.
     Correlations of MMP-2 and MMP-9 gene polymorphisms with the risk of hepatopulmonary syndrome in cirrhotic patients: a case-control study
     Kaohsiung J Med Sci34, 634-642. PubMed  Europe PubMed DOI  M
131. Mangiatordi,G.F., Guzzo,T., Rossano,E.C., Trisciuzzi,D., Alberga,D., Fasciglione,G., Coletta,M., Topai,A. and Nicolotti,O.
     Design, synthesis, and biological evaluation of tetrahydro-beta-carboline derivatives as selective sub-nanomolar gelatinase inhibitors
     ChemMedChem13, 1343-1352. PubMed  Europe PubMed DOI  I
132. Nadolski,G.J., Hunt,S.J., Weber,C.N., Mohammed,M., Pulido,S., Noji,M., Chisholm,A. and Gade,T.P.F.
     Near-infrared fluorescence imaging of matrix metalloproteinase 2 activity as a biomarker of vascular remodeling in hemodialysis access
     J Vasc Interv Radiol29, 1268-1275. PubMed  Europe PubMed DOI  L
133. Shamsara,J.
     Identification of non-zinc binding inhibitors of MMP-2 through virtual screening and subsequent rescoring
     Drug Res (Stuttg)68, 529-535. PubMed  Europe PubMed DOI  I
134. Tauro,M. and Lynch,C.C.
     Cutting to the chase: how matrix metalloproteinase-2 activity controls breast-cancer-to-bone metastasis
     Cancers (Basel)10, PubMed  Europe PubMed DOI
135. Zhang,H., Wang,X., Mao,J., Huang,Y., Xu,W., Duan,Y. and Zhang,J.
     Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity
     Bioorg Med Chem26, 4363-4374. PubMed  Europe PubMed DOI  I
2017
136. Adhikari,N., Mukherjee,A., Saha,A. and Jha,T.
     Arylsulfonamides and selectivity of matrix metalloproteinase-2: an overview
     Eur J Med Chem129, 72-109. PubMed  Europe PubMed DOI  V  I
137. Almalki,S.G., Llamas Valle,Y. and Agrawal,D.K.
     MMP-2 and MMP-14 silencing inhibits VEGFR2 cleavage and induces the differentiation of porcine adipose-derived mesenchymal stem cells to endothelial cells
     Stem Cells Transl Med6, 1385-1398. PubMed  Europe PubMed DOI  K
138. Ceron,C.S., Baligand,C., Joshi,S., Wanga,S., Cowley,P.M., Walker,J.P., Song,S.H., Mahimkar,R., Baker,A.J., Raffai,R.L., Wang,Z.J. and Lovett,D.H.
     An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury
     Am J Physiol Renal Physiol312, F1166-F1183. PubMed  Europe PubMed DOI
139. Cheng,H., Li,S.Y., Zheng,H.R., Li,C.X., Xie,B.R., Chen,K.W., Li,B. and Zhang,X.Z.
     Multi-Forster resonance energy transfer-based fluorescent probe for spatiotemporal matrix metalloproteinase-2 and caspase-3 imaging
     Anal Chem89, 4349-4354. PubMed  Europe PubMed DOI  L
140. Chowdhury,A., Nandy,S.K., Sarkar,J., Chakraborti,T. and Chakraborti,S.
     Inhibition of pro-/active MMP-2 by green tea catechins and prediction of their interaction by molecular docking studies
     Mol Cell Biochem427, 111-122. PubMed  Europe PubMed DOI  I
141. Kim,S.S., Shin,N., Bae,S.S., Lee,M.Y., Rhee,H., Kim,I.Y., Seong,E.Y., Lee,D.W., Lee,S.B., Kwak,I.S., Lovett,D.H. and Song,S.H.
     Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy
     PLoS ONE12, e0171625-e0171625. PubMed  Europe PubMed DOI
142. Mukherjee,A., Adhikari,N. and Jha,T.
     A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line
     Eur J Med Chem141, 37-50. PubMed  Europe PubMed DOI  I
143. Pillai,S.S., Yukawa,H., Onoshima,D., Biju,V. and Baba,Y.
     Forster resonance energy transfer mediated photoluminescence quenching in stoichiometrically assembled CdSe/ZnS quantum dot-peptide labeled black hole quencher conjugates for matrix metalloproteinase-2 sensing
     Anal Sci33, 137-142. PubMed  Europe PubMed DOI  L
144. Tauro,M., Shay,G., Sansil,S.S., Laghezza,A., Tortorella,P., Neuger,A.M., Soliman,H. and Lynch,C.C.
     Bone-seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth
     Mol Cancer Ther16, 494-505. PubMed  Europe PubMed DOI  I
145. Zhu,X., Lin,H., Wang,L., Tang,X., Ma,L., Chen,Z. and Gao,J.
     Activatable T1 relaxivity recovery nanoconjugates for kinetic and sensitive analysis of matrix metalloprotease 2
     ACS Appl Mater Interfaces9, 21688-21696. PubMed  Europe PubMed DOI  L
2016
146. Adhikari,N., Halder,A.K., Mallick,S., Saha,A., Saha,K.D. and Jha,T.
     Robust design of some selective matrix metalloproteinase-2 inhibitors over matrix metalloproteinase-9 through in silico/fragment-based lead identification and de novo lead modification: Syntheses and biological assays
     Bioorg Med Chem24, 4291-4309. PubMed  Europe PubMed DOI  I
147. Ammazzalorso,A., De Filippis,B., Campestre,C., Laghezza,A., Marrone,A., Amoroso,R., Tortorella,P. and Agamennone,M.
     Seeking for non-zinc-binding MMP-2 inhibitors: synthesis, biological evaluation and molecular modelling studies
     Int J Mol Sci17, PubMed  Europe PubMed DOI  I
148. Bae,M.J., Karadeniz,F., Lee,S.G., Seo,Y. and Kong,C.S.
     Inhibition of MMP-2 and MMP-9 activities by Limonium tetragonum extract
     Prev Nutr Food Sci21, 38-43. PubMed  Europe PubMed DOI  I
149. Beber,A.R., Polina,E.R., Biolo,A., Santos,B.L., Gomes,D.C., La Porta,V.L., Olsen,V., Clausell,N., Rohde,L.E. and Santos,K.G.
     Matrix metalloproteinase-2 polymorphisms in chronic heart failure: relationship with susceptibility and long-term survival
     PLoS ONE11, e0161666-e0161666. PubMed  Europe PubMed DOI  M
150. Bourguet,E., Brazhnik,K., Sukhanova,A., Moroy,G., Brassart-Pasco,S., Martin,A.P., Villena,I., Bellon,G., Sapi,J. and Nabiev,I.
     Design, synthesis, and use of MMP-2 inhibitor-conjugated quantum dots in functional biochemical assays
     Bioconjug Chem27, 1067-1081. PubMed  Europe PubMed DOI  L  I
151. Dang,Q., Gao,H., Li,Z., Qi,H., Gao,Q. and Zhang,C.
     Simple and sensitive electrogenerated chemiluminescence peptide-based biosensor for detection of matrix metalloproteinase 2 released from living cells
     Anal Bioanal Chem408, 7067-7075. PubMed  Europe PubMed DOI  A  L
152. Gao,M., Zhang,H., Trivedi,A., Mahasenan,K.V., Schroeder,V.A., Wolter,W.R., Suckow,M.A., Mobashery,S., Noble-Haeusslein,L.J. and Chang,M.
     Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury
     ACS Chem Neurosci7, 1482-1487. PubMed  Europe PubMed DOI  I
153. Gerwien,H., Hermann,S., Zhang,X., Korpos,E., Song,J., Kopka,K., Faust,A., Wenning,C., Gross,C.C., Honold,L., Melzer,N., Opdenakker,G., Wiendl,H., Schafers,M. and Sorokin,L.
     Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
     Sci Transl Med8, 364ra152-364ra. PubMed  Europe PubMed DOI  L
154. He,W., Jiang,J., Yu,Z.Q. and Zhou,J.H.
     Novel 5-hydroxy, 5-substituted benzenesulfonamide pyrimidine-2,4,6-triones attenuate lipopolysaccharide-induced acute lung injury via inhibition of the gelatinases, MMP-2 and MMP-9
     Drug Dev Res77, 251-257. PubMed  Europe PubMed DOI  I
155. Jha,S., Kanaujia,S.P. and Limaye,A.M.
     Direct inhibition of matrix metalloproteinase-2 (MMP-2) by (-)-epigallocatechin-3-gallate: a possible role for the fibronectin type II repeats
     Gene593, 126-130. PubMed  Europe PubMed DOI  I
156. Joshi,S.K., Lee,L., Lovett,D.H., Kang,H., Kim,H.T., Delgado,C. and Liu,X.
     Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury
     J Orthop Res34, 502-509. PubMed  Europe PubMed DOI
157. Jun-Zhang, Wang,X.-J., Dong,Z.-K., Wang,S.-Q., Xu,W.-R., Fu,J.-W., Cheng,X.-C. and Wang,R.-L.
     CoMFA/CoMSIA and molecular docking studies of novel matrix metalloproteinase- 2 inhibitors based on l-tyrosine scaffold
     Lett Drug Des Discov13, 376-386.  I
158. Khrenova,M.G., Solovyev,I.D., Azev,V.N., Lapshin,G.D. and Savitsky,A.P.
     Oxoethylene derivative of the natural substrate as an inhibitor of matrix metalloproteinase MMP-2
     Mendeleev Commun26, 207-208. DOI  I
159. Lemmens,K., Hove,I.V. and Moons,L.
     Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration
     Neural Regen Res11, 740-742. PubMed  Europe PubMed DOI
160. Nambiar,J., Bose,C., Venugopal,M., Banerji,A., Patel,T.B., Kumar,G.B. and Nair,B.G.
     Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK
     Exp Cell Res349, 139-151. PubMed  Europe PubMed DOI  I
161. Vasilevskaya,T., Khrenova,M.G., Nemukhin,A.V. and Thiel,W.
     Methodological aspects of QM/MM calculations: a case study on matrix metalloproteinase-2
     J Comput Chem37, 1801-1809. PubMed  Europe PubMed DOI  S
162. Wang,D., Yuan,Y., Zheng,Y., Chai,Y. and Yuan,R.
     An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification
     Chem Commun (Camb)52, 5943-5945. PubMed  Europe PubMed DOI  A
163. Xi,G., Wang,X. and Chen,T.
     A reduced graphene oxide-based fluorescence resonance energy transfer sensor for highly sensitive detection of matrix metalloproteinase 2
     Int J Nanomedicine11, 1537-1547. PubMed  Europe PubMed DOI  A
164. Yang,J.K., Kwak,S.Y., Jeon,S.J., Lee,E., Ju,J.M., Kim,H.I., Lee,Y.S. and Kim,J.H.
     Proteolytic disassembly of peptide-mediated graphene oxide assemblies for turn-on fluorescence sensing of proteases
     Nanoscale8, 12272-12281. PubMed  Europe PubMed DOI  A
165. Zhang,L., Ren,R. and Mu,S.
     The correlation of MMP-2 polymorphisms and stroke
     Int J Clin Exp Med9, 4460-4466.  M
2015
166. Abbasi,M., Ramezani,F., Elyasi,M., Sadeghi-Aliabadi,H. and Amanlou,M.
     A study on quantitative structure-activity relationship and molecular docking of metalloproteinase inhibitors based on L-tyrosine scaffold
     Daru23, 29- PubMed  Europe PubMed DOI  I
167. Bauters,D., Scroyen,I., Van Hul,M. and Lijnen,H.R.
     Gelatinase A (MMP-2) promotes murine adipogenesis
     Biochim Biophys Acta1850, 1449-1456. PubMed  Europe PubMed DOI  K
168. Behrends,M., Wagner,S., Kopka,K., Schober,O., Schafers,M., Kumbhar,S., Waller,M. and Haufe,G.
     New matrix metalloproteinase inhibitors based on gamma-fluorinated alpha-aminocarboxylic and alpha-aminohydroxamic acids
     Bioorg Med Chem23, 3809-3818. PubMed  Europe PubMed DOI  I
169. Bianchini,F., Calugi,C., Ruzzolini,J., Menchi,G., Calorini,L., Guarna,A. and Trabocchi,A.
     A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9
     MedChemComm6, 277-282. DOI  I
170. Diaz,N. and Suarez,D.
     Extensive simulations of the full-length matrix metalloproteinase-2 enzyme in a prereactive complex with a collagen triple-helical peptide
     Biochemistry54, 1243-1258. PubMed  Europe PubMed DOI
171. Gasparovic,I., Cizmarevic,N.S., Lovrecic,L., Perkovic,O., Lavtar,P., Sepcic,J., Jazbec,S.S., Kapovic,M., Peterlin,B. and Ristic,S.
     MMP-2 -1575G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?
     J Neuroimmunol286, 13-15. PubMed  Europe PubMed DOI  M
172. Gupta,B., Mai,K., Lowe,S.B., Wakefield,D., Di Girolamo,N., Gaus,K., Reece,P.J. and Gooding,J.J.
     Ultrasensitive and specific measurement of protease activity using functionalized photonic crystals
     Anal Chem87, 9946-9953. PubMed  Europe PubMed DOI  A
173. Hadler-Olsen,E., Solli,A.I., Hafstad,A., Winberg,J.O. and Uhlin-Hansen,L.
     Intracellular MMP-2 activity in skeletal muscle is associated with type II fibers
     J Cell Physiol230, 160-169. PubMed  Europe PubMed DOI
174. Liu,Q., Pan,D., Cheng,C., Zhang,A., Ma,C., Wang,L., Zhang,D., Liu,H., Jiang,H., Wang,T., Xu,Y., Yang,R., Chen,F., Yang,M. and Zuo,C.
     Targeting of MMP2 activity in malignant tumors with a 68Ga-labeled gelatinase inhibitor cyclic peptide
     Nucl Med Biol42, 939-944. PubMed  Europe PubMed DOI  L
175. Nanjan,P., Nambiar,J., Nair,B.G. and Banerji,A.
     Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9
     Bioorg Med Chem23, 3781-3787. PubMed  Europe PubMed DOI  I
176. Nuti,E., Cantelmo,A.R., Gallo,C., Bruno,A., Bassani,B., Camodeca,C., Tuccinardi,T., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Martinelli,A., Dive,V., Albini,A. and Rossello,A.
     N-O-Isopropyl sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors: hit selection and in vivo antiangiogenic activity
     J Med Chem58, 7224-7240. PubMed  Europe PubMed DOI  I
177. Santamaria,S., Nuti,E., Cercignani,G., La Regina,G., Silvestri,R., Supuran,C.T. and Rossello,A.
     Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors
     J Enzyme Inhib Med Chem30, 947-954. PubMed  Europe PubMed DOI  I
178. Shen,M., Lee,J., Basu,R., Sakamuri,S.S., Wang,X., Fan,D. and Kassiri,Z.
     Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm
     Arterioscler Thromb Vasc Biol35, 888-898. PubMed  Europe PubMed DOI  K
179. Tveitaras,M.K., Skogstrand,T., Leh,S., Helle,F., Iversen,B.M., Chatziantoniou,C., Reed,R.K. and Hultstrom,M.
     Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction
     PLoS ONE10, e0143390-e0143390. PubMed  Europe PubMed DOI  K
180. Vasilevskaya,T., Khrenova,M.G., Nemukhin,A.V. and Thiel,W.
     Mechanism of proteolysis in matrix metalloproteinase-2 revealed by QM/MM modeling
     J Comput Chem36, 1621-1630. PubMed  Europe PubMed DOI
181. Wang,P.F., Qiu,H.Y., Baloch,S.K., Gong,H.B., Wang,Z.C. and Zhu,H.L.
     Synthesis, biological evaluation, and docking of dihydropyrazole sulfonamide containing 2-hydroxyphenyl moiety: a series of novel MMP-2 inhibitors
     Chem Biol Drug Des86, 1405-1410. PubMed  Europe PubMed DOI  I
182. Wang,X., Berry,E., Hernandez-Anzaldo,S., Sun,D., Adijiang,A., Li,L., Zhang,D. and Fernandez-Patron,C.
     MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells
     FEBS Lett589, 490-496. PubMed  Europe PubMed DOI
183. Wanga,S., Ceron,C.S., Delgado,C., Joshi,S.K., Spaulding,K., Walker,J.P., Song,S., Olson,J.L. and Lovett,D.H.
     Two distinct isoforms of matrix metalloproteinase-2 are associated with human delayed kidney graft function
     PLoS ONE10, e0136276-e0136276. PubMed  Europe PubMed DOI  R
184. Yan,X.Q., Wang,Z.C., Li,Z., Wang,P.F., Qiu,H.Y., Chen,L.W., Lu,X.Y., Lv,P.C. and Zhu,H.L.
     Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: design, synthesis, inhibitory activity and 3D-QSAR analysis
     Bioorg Med Chem Lett25, 4664-4671. PubMed  Europe PubMed DOI  I
185. Zapico,J.M., Puckowska,A., Filipiak,K., Coderch,C., de Pascual-Teresa,B. and Ramos,A.
     Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family
     Org Biomol Chem13, 142-156. PubMed  Europe PubMed DOI  I
2014
186. Bencsik,P., Paloczi,J., Kocsis,G.F., Pipis,J., Belecz,I., Varga,Z.V., Csonka,C., Gorbe,A., Csont,T. and Ferdinandy,P.
     Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective
     Pharmacol Res80, 36-42. PubMed  Europe PubMed DOI  I
187. Ekbote,A.V., Danda,S., Zankl,A., Mandal,K., Maguire,T. and Ungerer,K.
     Patient with mutation in the matrix metalloproteinase 2 (MMP2) gene - a case report and review of the literature
     J Clin Res Pediatr Endocrinol6, 40-46. PubMed  Europe PubMed DOI  M
188. Fabre,B., Filipiak,K., Diaz,N., Zapico,J.M., Suarez,D., Ramos,A. and de Pascual-Teresa,B.
     An integrated computational and experimental approach to gaining selectivity for MMP-2 within the gelatinase subfamily
     Chembiochem15, 399-412. PubMed  Europe PubMed DOI  I
189. Fan,G.C., Han,L., Zhu,H., Zhang,J.R. and Zhu,J.J.
     Ultrasensitive photoelectrochemical immunoassay for matrix metalloproteinase-2 detection based on CdS:Mn/CdTe cosensitized TiO2 nanotubes and signal amplification of SiO2@Ab2 conjugates
     Anal Chem86, 12398-12405. PubMed  Europe PubMed DOI  A  L
190. Filipiak,K., Kubinski,K., Hellman,U., Ramos,A. and de Pascual-Teresa,B.
     Human protein kinase CK2 phosphorylates matrix metalloproteinase 2 and inhibits its activity
     Chembiochem15, 1873-1876. PubMed  Europe PubMed DOI
191. Gaublomme,D., Buyens,T., De Groef,L., Stakenborg,M., Janssens,E., Ingvarsen,S., Porse,A., Behrendt,N. and Moons,L.
     Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells
     J Neurochem129, 966-979. PubMed  Europe PubMed DOI
192. Hua,D., Kong,W., Zheng,X., Zhou,Z., Yu,B., Li,Y., Wang,Y., Yang,X., Liu,C., Tang,L., Li,Y. and Gong,M.
     Potent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics
     Drug Des Devel Ther8, 1839-1849. PubMed  Europe PubMed DOI
193. Hughes,B.G., Fan,X., Cho,W.J. and Schulz,R.
     MMP-2 is localized to the mitochondria-associated membrane of the heart
     Am J Physiol Heart Circ Physiol306, H764-H770. PubMed  Europe PubMed DOI
194. Iwao,Y., Shiga,K., Shiroshita,A., Yoshikawa,T., Sakiie,M., Ueno,T., Ueno,S., Ijiri,T.W. and Sato,K.-I.
     The need of MMP-2 on the sperm surface for Xenopus fertilization: its role in a fast electrical block to polyspermy
     Mech Dev134, 80-95. PubMed  Europe PubMed DOI
195. Kang,S.G., Araya-Secchi,R., Wang,D., Wang,B., Huynh,T. and Zhou,R.
     Dual inhibitory pathways of metallofullerenol Gd@C82(OH)22 on matrix metalloproteinase-2: molecular insight into drug-like nanomedicine
     Sci Rep4, 4775-4775. PubMed  Europe PubMed DOI  I
196. Kuntze,L.B., Antonio,R.C., Izidoro-Toledo,T.C., Meschiari,C.A., Tanus-Santos,J.E. and Gerlach,R.F.
     Captopril and lisinopril only inhibit matrix metalloproteinase-2 (MMP-2) activity at millimolar concentrations
     Basic Clin Pharmacol Toxicol114, 233-239. PubMed  Europe PubMed DOI  I
197. Lauer,J.L., Bhowmick,M., Tokmina-Roszyk,D., Lin,Y., Van Doren,S.R. and Fields,G.B.
     The role of collagen charge clusters in the modulation of matrix metalloproteinase activity
     J Biol Chem289, 1981-1992. PubMed  Europe PubMed DOI  P
198. Marcial,B.L., Sousa,S.F., Santos,H.F. and Ramos,M.J.
     Structural and dynamics analysis of matrix metalloproteinases MMP-2 complexed with chemically modified tetracyclines (CMTs)
     J Biomol Struct Dyn32, 1907-1918. PubMed  Europe PubMed DOI  I
199. Qiu,H.-Y., Wang,Z.-C., Wang,P.-F., Yan,X.-Q., Wang,X.-M., Yang,Y.-H. and Zhu,H.-L.
     Design, synthesis, evaluation and 3D-QSAR analysis of benzosulfonamide benzenesulfonates as potent and selective inhibitors of MMP-2
     RSC Adv4, 39214-39225. DOI  I
200. Rossano,R., Larocca,M., Riviello,L., Coniglio,M.G., Vandooren,J., Liuzzi,G.M., Opdenakker,G. and Riccio,P.
     Heterogeneity of serum gelatinases MMP-2 and MMP-9 isoforms and charge variants
     J Cell Mol Med18, 242-252. PubMed  Europe PubMed DOI
201. van Duijnhoven,S.M., Robillard,M.S., Hermann,S., Kuhlmann,M.T., Schafers,M., Nicolay,K. and Grull,H.
     Imaging of MMP activity in postischemic cardiac remodeling using radiolabeled MMP-2/9 activatable peptide probes
     Mol Pharm11, 1415-1423. PubMed  Europe PubMed DOI  L
202. Verma,A., Rizvi,S.M., Shaikh,S., Ansari,M.A., Shakil,S., Ghazal,F., Siddiqui,M.H., Haneef,M. and Rehman,A.
     Compounds isolated from Ageratum houstonianum inhibit the activity of matrix metalloproteinases (MMP-2 and MMP-9): an oncoinformatics study
     Pharmacogn Mag10, 18-26. PubMed  Europe PubMed DOI  I
203. Wang,C., Zhan,C.L., Cai,Q.F., Du,C.H., Liu,G.M., Su,W.J. and Cao,M.J.
     Expression and characterization of common carp (Cyprinus carpio) matrix metalloproteinase-2 and its activity against type I collagen
     J Biotechnol177, 45-52. PubMed  Europe PubMed DOI
204. Wang,Z., Li,X., Feng,D., Li,L., Shi,W. and Ma,H.
     Poly(m-phenylenediamine)-based fluorescent nanoprobe for ultrasensitive detection of matrix metalloproteinase 2
     Anal Chem86, 7719-7725. PubMed  Europe PubMed DOI  A  L
205. Wu,J.L., Ge,S.Y., Cai,Z.X., Liu,H., Liu,Y.X., Wang,J.H. and Zhang,Q.Q.
     Purification and characterization of a gelatinolytic matrix metalloproteinase from the skeletal muscle of grass carp (Ctenopharyngodon idellus)
     Food Chem145, 632-638. PubMed  Europe PubMed DOI
206. Yari,K., Rahimi,Z., Moradi,M.-T. and Rahimi,Z.
     The MMP-2-735 C allele is a risk factor for susceptibility to breast cancer
     Asian Pac J Cancer Prev15, 6199-6203. DOI  M
207. Yari,K., Rahimi,Z., Moradi,M.T. and Rahimi,Z.
     The MMP-2 -735 C allele is a risk factor for susceptibility to breast cancer
     Asian Pac J Cancer Prev15, 6199-6203. PubMed  Europe PubMed  M
208. Yue,X., Wang,Z., Zhu,L., Wang,Y., Qian,C., Ma,Y., Kiesewetter,D.O., Niu,G. and Chen,X.
     Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS
     Mol Pharm11, 4208-4217. PubMed  Europe PubMed DOI  L
209. Zhang,J., Li,X., Jiang,Y., Feng,J., Li,X., Zhang,Y. and Xu,W.
     Design, synthesis and preliminary evaluation of alpha-sulfonyl gamma-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors
     Bioorg Med Chem22, 3055-3064. PubMed  Europe PubMed DOI  I
210. Zhang,X., Bresee,J., Fields,G.B. and Edwards,W.B.
     Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo
     Bioorg Med Chem Lett24, 3786-3790. PubMed  Europe PubMed DOI  L
211. Zhang,X., Bresee,J., Cheney,P.P., Xu,B., Bhowmick,M., Cudic,M., Fields,G.B. and Edwards,W.B.
     Evaluation of a triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity
     Molecules19, 8571-8588. PubMed  Europe PubMed DOI  L
2013
212. Alcantara,M.B. and Dass,C.R.
     Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer
     Cell Physiol Biochem31, 487-494. PubMed  Europe PubMed DOI
213. Casalini,F., Fugazza,L., Esposito,G., Cabella,C., Brioschi,C., Cordaro,A., D'Angeli,L., Bartoli,A., Filannino,A.M., Gringeri,C.V., Longo,D.L., Muzio,V., Nuti,E., Orlandini,E., Figlia,G., Quattrini,A., Tei,L., Digilio,G., Rossello,A. and Maiocchi,A.
     Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography
     J Med Chem56, 2676-2689. PubMed  Europe PubMed DOI  L  I
214. Castro,M.M., Fuah,J., Ali,M., Sung,M., Schulz,J., Kondo,M.Y., Fan,X., Holt,A. and Schulz,R.
     Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2
     Biochem Pharmacol86, 469-475. PubMed  Europe PubMed DOI  I
215. Diaz,N., Suarez,D. and Valdes,H.
     Unraveling the molecular structure of the catalytic domain of matrix metalloproteinase-2 in complex with a triple-helical peptide by means of molecular dynamics simulations
     Biochemistry52, 8556-8569. PubMed  Europe PubMed DOI
216. Fabre,B., Filipiak,K., Zapico,J.M., Diaz,N., Carbajo,R.J., Schott,A.K., Martinez-Alcazar,M.P., Suarez,D., Pineda-Lucena,A., Ramos,A. and de Pascual-Teresa,B.
     Progress towards water-soluble triazole-based selective MMP-2 inhibitors
     Org Biomol Chem11, 6623-6641. PubMed  Europe PubMed DOI  I
217. Freskos,J.N., Asmelash,B., Gaston,K.R., Karwa,A., Marzan,T.A., Nickols,M.A., Rogers,T.E., Schoenstein,T., Sympson,C.J. and Vu,B.
     Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes
     Bioorg Med Chem Lett23, 5566-5570. PubMed  Europe PubMed DOI  L  I
218. Givvimani,S., Kundu,S., Narayanan,N., Armaghan,F., Qipshidze,N., Pushpakumar,S., Vacek,T.P. and Tyagi,S.C.
     TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure
     Arch Physiol Biochem119, 65-74. PubMed  Europe PubMed DOI  K
219. Gooyit,M., Song,W., Mahasenan,K.V., Lichtenwalter,K., Suckow,M.A., Schroeder,V.A., Wolter,W.R., Mobashery,S. and Chang,M.
     O-Phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier
     J Med Chem56, 8139-8150. PubMed  Europe PubMed DOI  I
220. Halder,A.K., Saha,A. and Jha,T.
     Exploring QSAR and pharmacophore mapping of structurally diverse selective matrix metalloproteinase-2 inhibitors
     J Pharm Pharmacol65, 1541-1554. PubMed  Europe PubMed DOI  I
221. Higashi,S., Hirose,T., Takeuchi,T. and Miyazaki,K.
     Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2)
     J Biol Chem288, 9066-9076. PubMed  Europe PubMed DOI
222. Hugenberg,V., Riemann,B., Hermann,S., Schober,O., Schafers,M., Szardenings,K., Lebedev,A., Gangadharmath,U., Kolb,H., Walsh,J., Zhang,W., Kopka,K. and Wagner,S.
     Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (Radio)synthesis, in vitro and first in vivo evaluation
     J Med Chem56, 6858-6870. PubMed  Europe PubMed DOI  I
223. Jacob-Ferreira,A.L. and Schulz,R.
     Activation of intracellular matrix metalloproteinase-2 by reactive oxygen-nitrogen species: consequences and therapeutic strategies in the heart
     Arch Biochem Biophys540, 82-93. PubMed  Europe PubMed DOI
224. Ji,M.K., Shi,Y., Xu,J.W., Lin,X. and Lin,J.Y.
     Recombinant snake venom metalloproteinase inhibitor BJ46A inhibits invasion and metastasis of B16F10 and MHCC97H cells through reductions of matrix metalloproteinases 2 and 9 activities
     Anticancer Drugs24, 461-472. PubMed  Europe PubMed DOI  E  U
225. Kreituss,I., Rozenberga,E., Zemitis,J., Trapencieris,P., Romanchikova,N. and Turks,M.
     Discovery of aziridine-triazole conjugates as selective MMP-2 inhibitors
     Chem Heterocycl Compd49, 1108-1117. DOI  I
226. Lovett,D.H., Mahimkar,R., Raffai,R.L., Cape,L., Zhu,B.Q., Jin,Z.Q., Baker,A.J. and Karliner,J.S.
     N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure
     PLoS ONE8, e68154-e68154. PubMed  Europe PubMed DOI
227. Marques,S.M., Abate,C.C., Chaves,S., Marques,F., Santos,I., Nuti,E., Rossello,A. and Santos,M.A.
     New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy
     J Inorg Biochem127, 188-202. PubMed  Europe PubMed DOI  I
228. Pizio,A.D., Laghezza,A., Tortorella,P. and Agamennone,M.
     Probing the S1' site for the identification of non-zinc-binding MMP-2 inhibitors
     ChemMedChem8, 1475-1482. PubMed  Europe PubMed DOI  I
229. Rastogi,A., Kim,H., Twomey,J.D. and Hsieh,A.H.
     MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc
     Arthritis Res Ther15, R57-R57. PubMed  Europe PubMed DOI
230. Ryu,J.H., Shin,J.Y., Kim,S.A., Kang,S.W., Kim,H., Kang,S., Choi,K., Kwon,I.C., Kim,B.S. and Kim,K.
     Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model
     Biomaterials34, 6871-6881. PubMed  Europe PubMed DOI  L
231. Shi,Z.H., Li,N.G., Shi,Q.P., Tang,H., Tang,Y.P., Li,W., Yin,L., Yang,J.P. and Duan,J.A.
     Design, synthesis and biological evaluation of ferulic acid amides as selective matrix metalloproteinase inhibitors
     Med Chem9, 947-954. PubMed  Europe PubMed DOI  I
232. Takahashi,T., Fujimori,C., Hagiwara,A. and Ogiwara,K.
     Recent advances in the understanding of teleost medaka ovulation: the roles of proteases and prostaglandins
     Zoolog Sci30, 239-247. PubMed  Europe PubMed DOI
233. Tauro,M., Laghezza,A., Loiodice,F., Agamennone,M., Campestre,C. and Tortorella,P.
     Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors
     Bioorg Med Chem21, 6456-6465. PubMed  Europe PubMed DOI  I
234. Verslegers,M., Lemmens,K., Van Hove,I. and Moons,L.
     Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system
     Prog Neurobiol105, 60-78. PubMed  Europe PubMed DOI  V
235. Yoon,H.K. and Yoo,T.H.
     A novel protease activity assay method based on an engineered autoinhibited protein using an enzyme-linked immunoassay
     Analyst138, 7164-7168. PubMed  Europe PubMed DOI  A
236. Zheng,T., Zhang,R., Zhang,Q., Tan,T., Zhang,K., Zhu,J.J. and Wang,H.
     Ultrasensitive dual-channel detection of matrix metalloproteinase-2 in human serum using gold-quantum dot core-satellite nanoprobes
     Chem Commun (Camb)49, 7881-7883. PubMed  Europe PubMed DOI  A
237. Zhong,H.A., Arbiser,J. and Bowen,J.P.
     Selectivity, binding affinity, and ionization state of matrix metalloproteinase inhibitors
     Curr Pharm Des19, 4701-4713. PubMed  Europe PubMed DOI  I
2012
238. Alam,M., Ali,S.A., Abbasi,A., Kalbacher,H. and Voelter,W.
     Design and synthesis of a peptidyl-FRET substrate for tumor marker enzyme human matrix metalloprotease-2 (hMMP-2)
     Int J Pept Res Ther18, 207-215. DOI  A
239. Ali,M.A., Chow,A.K., Kandasamy,A.D., Fan,X., West,L.J., Crawford,B.D., Simmen,T. and Schulz,R.
     Mechanisms of cytosolic targeting of matrix metalloproteinase-2
     J Cell Physiol227, 3397-3404. PubMed  Europe PubMed DOI
240. Bu,Z., Pan,Y., Shang,B., Cao,Z., Zhou,Q. and Ruan,C.
     SZ-117, a monoclonal antibody against matrix metalloproteinase-2 inhibits tumor cell-mediated angiogenesis
     Hybridoma (Larchmt)31, 63-67. PubMed  Europe PubMed DOI
241. Burkhart,J.L., Diehl,B., Schmitt,M.J. and Kazmaier,U.
     A straightforward approach to MMP-2 and MMP-9 inhibitors based on chelate claisen rearrangements
     Eur J Org Chem2012, 567-575. DOI  I
242. Cheng,X.C., Wang,R.L., Dong,Z.K., Li,J., Li,Y.Y. and Li,R.R.
     Design, synthesis and evaluation of novel metalloproteinase inhibitors based on l-tyrosine scaffold
     Bioorg Med Chem20, 5738-5744. PubMed  Europe PubMed DOI  I
243. Christianson,C.A., Fitzsimmons,B.L., Shim,J.H., Agrawal,A., Cohen,S.M., Hua,X.Y. and Yaksh,T.L.
     Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism
     Neuroscience200, 199-210. PubMed  Europe PubMed DOI  I
244. Chuang,C.H., Chuang,K.H., Wang,H.E., Roffler,S.R., Shiea,J.T., Tzou,S.C., Cheng,T.C., Kao,C.H., Wu,S.Y., Tseng,W.L., Cheng,C.M., Hou,M.F., Wang,J.M. and Cheng,T.L.
     In vivo positron emission tomography imaging of protease activity by generation of a hydrophobic product from a noninhibitory protease substrate
     Clin Cancer Res18, 238-247. PubMed  Europe PubMed DOI  L
245. de Melo,E.B.
     A QSAR study of matrix metalloproteinases type 2 (MMP-2) inhibitors with cinnamoyl pyrrolidine derivatives
     Sci Pharm80, 265-281. PubMed  Europe PubMed DOI  I
246. Detry,B., Erpicum,C., Paupert,J., Blacher,S., Maillard,C., Bruyere,F., Pendeville,H., Remacle,T., Lambert,V., Balsat,C., Ormenese,S., Lamaye,F., Janssens,E., Moons,L., Cataldo,D., Kridelka,F., Carmeliet,P., Thiry,M., Foidart,J.M., Struman,I. and Noel,A.
     Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase
     Blood119, 5048-5056. PubMed  Europe PubMed DOI
247. Di Pizio,A., Agamennone,M. and Aschi,M.
     An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors
     PLoS ONE7, e47774-e47774. PubMed  Europe PubMed DOI  I
248. Frankowski,H., Gu,Y.H., Heo,J.H., Milner,R. and del Zoppo,G.J.
     Use of gel zymography to examine matrix metalloproteinase (gelatinase) expression in brain tissue or in primary glial cultures
     Methods Mol Biol814, 221-233. PubMed  Europe PubMed DOI  A
249. Harney,A.S., Sole,L.B. and Meade,T.J.
     Kinetics and thermodynamics of irreversible inhibition of matrix metalloproteinase2 by a Co(III) Schiff base complex
     J Biol Inorg Chem17, 853-860. PubMed  Europe PubMed DOI  I
250. Koo,B.H., Kim,Y.H., Han,J.H. and Kim,D.S.
     Dimerization of matrix metalloproteinase-2 (MMP-2): functional implication in MMP-2 activation
     J Biol Chem287, 22643-22653. PubMed  Europe PubMed DOI
251. Lacchini,R., Jacob-Ferreira,A.L., Luizon,M.R., Gasparini,S., Ferreira-Sae,M.C., Schreiber,R., Nadruz,W., Jr. and Tanus-Santos,J.E.
     Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients
     J Hum Hypertens26, 171-177. PubMed  Europe PubMed DOI  M
252. Marcial,B.L., Sousa,S.F., Barbosa,I.L., Dos Santos,H.F. and Ramos,M.J.
     Chemically modified tetracyclines as inhibitors of MMP-2 matrix metalloproteinase: a molecular and structural study
     J Phys Chem B116, 13644-13654. PubMed  Europe PubMed DOI  I
253. Mikhailova,M., Xu,X., Robichaud,T.K., Pal,S., Fields,G.B. and Steffensen,B.
     Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2)
     Matrix Biol31, 380-388. PubMed  Europe PubMed DOI
254. Murphy,G.
     Matrix metallopeptidase-2/gelatinase A
     [ISSN:978-0-12-407744-7]3, 747-753. DOI
255. Nicolotti,O., Catto,M., Giangreco,I., Barletta,M., Leonetti,F., Stefanachi,A., Pisani,L., Cellamare,S., Tortorella,P., Loiodice,F. and Carotti,A.
     Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9
     Eur J Med Chem58, 368-376. PubMed  Europe PubMed DOI  I
256. Peng,H., Wu,Y., Duan,Z., Ciborowski,P. and Zheng,J.C.
     Proteolytic processing of SDF-1alpha by matrix metalloproteinase-2 impairs CXCR4 signaling and reduces neural progenitor cell migration
     Protein Cell3, 875-882. PubMed  Europe PubMed DOI
257. Rah,B., Amin,H., Yousuf,K., Khan,S., Jamwal,G., Mukherjee,D. and Goswami,A.
     A novel MMP-2 inhibitor 3-azidowithaferin A (3-azidoWA) abrogates cancer cell invasion and angiogenesis by modulating extracellular Par-4
     PLoS ONE7, e44039-e44039. PubMed  Europe PubMed DOI  I
258. Serra,P., Bruczko,M., Zapico,J.M., Puckowska,A., Garcia,M.A., Martin-Santamari,S., Ramos,A. and de Pascual-Teresa,B.
     MMP-2 selectivity in hydroxamate-type inhibitors
     Curr Med Chem19, 1036-1064. PubMed  Europe PubMed  I
259. Shi,Z.H., Li,N.G., Shi,Q.P., Hao,T. and Tang,Y.P.
     Design, synthesis, and preliminary evaluation of substituted cinnamic acid esters as selective matrix metalloproteinase inhibitors
     Drug Dev Res73, 317-324. DOI  I
260. Tanakit,A., Rouffet,M., Martin,D.P. and Cohen,S.M.
     Investigating chelating sulfonamides and their use in metalloproteinase inhibitors
     Dalton Trans41, 6507-6515. PubMed  Europe PubMed DOI  I
261. Thiolloy,S., Edwards,J.R., Fingleton,B., Rifkin,D.B., Matrisian,L.M. and Lynch,C.C.
     An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment
     PLoS ONE7, e29862-e29862. PubMed  Europe PubMed DOI
262. Topai,A., Breccia,P., Minissi,F., Padova,A., Marini,S. and Cerbara,I.
     In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors
     Bioorg Med Chem20, 2323-2337. PubMed  Europe PubMed DOI  I
263. Verhille,M., Benachour,H., Ibrahim,A., Achard,M., Arnoux,P., Barberi-Heyob,M., Andre,J.C., Allonas,X., Baros,F., Vanderesse,R. and Frochot,C.
     Photodynamic molecular beacons triggered by MMP-2 and MMP-9: influence of the distance between photosensitizer and quencher onto photophysical properties and enzymatic activation
     Curr Med Chem19, 5580-5594. PubMed  Europe PubMed DOI  A
264. Wang,N., Zhu,M., Tsao,S.W., Man,K., Zhang,Z. and Feng,Y.
     Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma
     PLoS ONE7, e46318-e46318. PubMed  Europe PubMed DOI
265. Wang,Y., Shen,P., Li,C., Wang,Y. and Liu,Z.
     Upconversion fluorescence resonance energy transfer based biosensor for ultrasensitive detection of matrix metalloproteinase-2 in blood
     Anal Chem84, 1466-1473. PubMed  Europe PubMed DOI  A
266. Yamamoto,D., Takai,S., Akimoto,T., Hirahara,I., Ito,C., Muto,S. and Kusano,E.
     Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport
     Clin Exp Pharmacol Physiol39, 864-868. PubMed  Europe PubMed DOI  I
267. Yamamoto,N., Bryce,N.S., Metzler-Nolte,N. and Hambley,T.W.
     Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids
     Bioconjug Chem23, 1110-1118. PubMed  Europe PubMed DOI
2011
268. Choi,S.S., Ji,A.R., Yu,S.W., Cho,B.H., Park,J.D., Park,J.H., Lee,H.S., Ryu,S.E., Kim,D.H., Kang,J.H. and Lee,S.T.
     Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors
     Bull Korean Chem Soc32, 2032-2038. DOI  I
269. Diehl,B., Hoffmann,T.M., Mueller,N.C., Burkhart,J.L., Kazmaier,U. and Schmitt,M.J.
     Novel yeast bioassay for high-throughput screening of matrix metalloproteinase inhibitors
     Appl Environ Microbiol77, 8573-8577. PubMed  Europe PubMed DOI  I
270. Feng,D., Zhang,Y., Feng,T., Shi,W., Li,X. and Ma,H.
     A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2
     Chem Commun (Camb)47, 10680-10682. PubMed  Europe PubMed DOI  A
271. Giangreco,I., Lattanzi,G., Nicolotti,O., Catto,M., Laghezza,A., Leonetti,F., Stefanachi,A. and Carotti,A.
     Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations
     PLoS ONE6, e25597-e25597. PubMed  Europe PubMed DOI  I
272. Jo,Y.K., Park,S.J., Shin,J.H., Kim,Y., Hwang,J.J., Cho,D.H. and Kim,J.C.
     ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells
     Biochem Biophys Res Commun404, 1039-1043. PubMed  Europe PubMed DOI  I
273. Liu,X.
     Emerging ideas: matrix metalloproteinase-2 in muscle atrophy
     Clin Orthop Relat Res469, 1797-1799. PubMed  Europe PubMed DOI
274. Moroy,G., Bourguet,E., Decarme,M., Sapi,J., Alix,A.J., Hornebeck,W. and Lorimier,S.
     Inhibition of human leukocyte elastase, plasmin and matrix metalloproteinases by oleic acid and oleoyl-galardin derivative(s)
     Biochem Pharmacol81, 626-635. PubMed  Europe PubMed DOI  I
275. Robichaud,T.K., Steffensen,B. and Fields,G.B.
     Exosite interactions impact matrix metalloproteinase collagen specificities
     J Biol Chem286, 37535-37542. PubMed  Europe PubMed DOI  P
276. Saygili,E., Schauerte,P., Pekassa,M., Saygili,E., Rackauskas,G., Schwinger,R.H.G., Weis,J., Weber,C., Marx,N. and Rana,O.R.
     Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion
     Cell Mol Neurobiol31, 17-25. PubMed  Europe PubMed DOI
277. Testero,S.A., Llarrull,L.I., Fisher,J.F., Chang,M. and Mobashery,S.
     Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry
     Arkivoc2011, 221-236.  I
278. Testero,S.A., Lee,M., Staran,R.T., Espahbodi,M., Llarrull,L.I., Toth,M., Mobashery,S. and Chang,M.
     Sulfonate-containing thiiranes as selective gelatinase inhibitors
     ACS Med Chem Lett2, 177-181. PubMed  Europe PubMed DOI  I
279. Tremblay,P., Beaudet,M.J., Tremblay,E., Rueda,N., Thomas,T. and Vallieres,L.
     Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair
     J Pathol224, 222-233. PubMed  Europe PubMed DOI
280. Wang,J., Medina,C., Radomski,M.W. and Gilmer,J.F.
     N-Substituted homopiperazine barbiturates as gelatinase inhibitors
     Bioorg Med Chem19, 4985-4999. PubMed  Europe PubMed DOI  I
281. Westermann,D., Savvatis,K., Lindner,D., Zietsch,C., Becher,P.M., Hammer,E., Heimesaat,M.M., Bereswill,S., Volker,U., Escher,F., Riad,A., Plendl,J., Klingel,K., Poller,W., Schultheiss,H.P. and Tschope,C.
     Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy
     Circulation124, 2082-2093. PubMed  Europe PubMed DOI  K
282. Wilson,L.J., Wang,B., Yang,S.M., Scannevin,R.H., Burke,S.L., Karnachi,P., Rhodes,K.J. and Murray,W.V.
     Discovery of novel cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy
     Bioorg Med Chem Lett21, 6485-6490. PubMed  Europe PubMed DOI  I
283. Xu,X., Mikhailova,M., Chen,Z., Pal,S., Robichaud,T.K., Lafer,E.M., Baber,S. and Steffensen,B.
     Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2)
     Matrix Biol30, 404-412. PubMed  Europe PubMed DOI
284. Zapico,J., Serra,P., Sanmartin,J.G., Filipiak,K., Martinez,A., Santamaria,S.M., de Pascual-Teresa,B. and Ramos,A.
     Synthesis of selective MMP-2 inhibitors using click chemistry
     An R Acad Farm77, 99-117.  I
2010
285. Ali,M.A., Cho,W.J., Hudson,B., Kassiri,Z., Granzier,H. and Schulz,R.
     Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury
     Circulation122, 2039-2047. PubMed  Europe PubMed DOI
286. Becker,D.P., Barta,T.E., Bedell,L.J., Boehm,T.L., Bond,B.R., Carroll,J., Carron,C.P., Decrescenzo,G.A., Easton,A.M., Freskos,J.N., Funckes-Shippy,C.L., Heron,M., Hockerman,S., Howard,C.P., Kiefer,J.R., Li,M.H., Mathis,K.J., McDonald,J.J., Mehta,P.P., Munie,G.E., Sunyer,T., Swearingen,C.A., Villamil,C.I., Welsch,D., Williams,J.M., Yu,Y. and Yao,J.
     Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease
     J Med Chem53, 6653-6680. PubMed  Europe PubMed DOI  I
287. Bruni-Cardoso,A., Lynch,C.C., Rosa-Ribeiro,R., Matrisian,L.M. and Carvalho,H.F.
     MMP-2 contributes to the development of the mouse ventral prostate by impacting epithelial growth and morphogenesis
     Dev Dyn239, 2386-2392. PubMed  Europe PubMed DOI  K
288. Emara,M. and Wozniak,M.
     In vitro inhibition of human MMP-2 collagenolytic and gelatinolytic activity by neutralizing monoclonal antibodies
     Immunol Invest39, 833-848. PubMed  Europe PubMed DOI
289. Gioia,M., Fasciglione,G.F., Monaco,S., Iundusi,R., Sbardella,D., Marini,S., Tarantino,U. and Coletta,M.
     pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain
     J Biol Inorg Chem15, 1219-1232. PubMed  Europe PubMed DOI
290. Hernandez-Guillamon,M., Mawhirt,S., Fossati,S., Blais,S., Pares,M., Penalba,A., Boada,M., Couraud,P.O., Neubert,T.A., Montaner,J., Ghiso,J. and Rostagno,A.
     Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells
     J Biol Chem285, 27144-27158. PubMed  Europe PubMed DOI
291. Kim,J.H. and Chung,B.H.
     Proteolytic fluorescent signal amplification on gold nanoparticles for a highly sensitive and rapid protease assay
     Small6, 126-131. PubMed  Europe PubMed DOI  A
292. Linke,W.A.
     Molecular giant vulnerable to oxidative damage: titin joins the club of proteins degraded by matrix metalloproteinase-2
     Circulation122, 2002-2004. PubMed  Europe PubMed DOI
293. Manso,H., Krug,T., Sobral,J., Albergaria,I., Gaspar,G., Ferro,J.M., Oliveira,S.A. and Vicente,A.M.
     Variants of the matrix metalloproteinase-2 but not the matrix metalloproteinase-9 genes significantly influence functional outcome after stroke
     BMC Med Genet11, 40-40. PubMed  Europe PubMed DOI  M
294. Tao,P., Fisher,J.F., Shi,Q., Mobashery,S. and Schlegel,H.B.
     Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT
     J Phys Chem B114, 1030-1037. PubMed  Europe PubMed DOI  I
295. Ulmer,T.A., Keeler,V., Andre,S., Gabius,H.J., Loh,L. and Laferte,S.
     The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic cleavage
     Biochim Biophys Acta1800, 336-343. PubMed  Europe PubMed DOI
2009
296. Burns,D.M., Li,Y.L., Shi,E., He,C., Xu,M., Zhuo,J., Zhang,C., Qian,D.Q., Li,Y., Wynn,R., Covington,M.B., Katiyar,K., Marando,C.A., Fridman,J.S., Scherle,P., Friedman,S., Metcalf,B. and Yao,W.
     Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition
     Bioorg Med Chem Lett19, 3525-3530. PubMed  Europe PubMed DOI  I
297. Carvalho,R.V., Ogliari,F.A., de Souza,A.P., Silva,A.F., Petzhold,C.L., Line,S.R., Piva,E. and Etges,A.
     2-Hydroxyethyl methacrylate as an inhibitor of matrix metalloproteinase-2
     Eur J Oral Sci117, 64-67. PubMed  Europe PubMed DOI  I
298. Chaussain,C., Eapen,A.S., Huet,E., Floris,C., Ravindran,S., Hao,J., Menashi,S. and George,A.
     MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell
     Eur Cell Mater18, 84-95. PubMed  Europe PubMed
299. Forbes,C., Shi,Q., Fisher,J.F., Lee,M., Hesek,D., Llarrull,L.I., Toth,M., Gossing,M., Fridman,R. and Mobashery,S.
     Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases
     Chem Biol Drug Des74, 527-534. PubMed  Europe PubMed DOI  I
300. Gooyit,M., Lee,M., Hesek,D., Boggess,B., Oliver,A.G., Fridman,R., Mobashery,S. and Chang,M.
     Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors
     Chem Biol Drug Des74, 535-546. PubMed  Europe PubMed DOI  I
301. Huang,H., Zhao,W., Tang,Z., Yang,S., Wu,Z., Zhao,S., Cui,W., Mu,Y., Chu,M. and Li,K.
     Characterization of porcine MMP-2 and its association with immune traits
     Gene435, 63-71. PubMed  Europe PubMed DOI
302. Jastrzebska,B., Lebel,R., Therriault,H., McIntyre,J.O., Escher,E., Guerin,B., Paquette,B., Neugebauer,W.A. and Lepage,M.
     New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging
     J Med Chem52, 1576-1581. PubMed  Europe PubMed DOI  L
303. Jung,J.C., Wang,P.X., Zhang,G., Ezura,Y., Fini,M.E. and Birk,D.E.
     Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation
     Cell Tissue Res336, 79-89. PubMed  Europe PubMed DOI
304. Kenny,H.A. and Lengyel,E.
     MMP-2 functions as an early response protein in ovarian cancer metastasis
     Cell Cycle8, 683-688. PubMed  Europe PubMed
305. Lee,M., Celenza,G., Boggess,B., Blase,J., Shi,Q., Toth,M., Bernardo,M.M., Wolter,W.R., Suckow,M.A., Hesek,D., Noll,B.C., Fridman,R., Mobashery,S. and Chang,M.
     A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition
     Chem Biol Drug Des73, 189-202. PubMed  Europe PubMed DOI  I
306. Lehmann,H.C., Kohne,A., Bernal,F., Jangouk,P., Meyer Zu Horste,G., Dehmel,T., Hartung,H.P., Previtali,S.C. and Kieseier,B.C.
     Matrix metalloproteinase-2 is involved in myelination of dorsal root ganglia neurons
     Glia57, 479-489. PubMed  Europe PubMed DOI
307. Murnane,M.J., Cai,J., Shuja,S., McAneny,D., Klepeis,V. and Willett,J.B.
     Active MMP-2 effectively identifies the presence of colorectal cancer
     Int J Cancer125, 2893-2902. PubMed  Europe PubMed DOI
308. Song,J.H., Kim,S.H., Cho,D., Lee,I.K., Kim,H.J. and Kim,T.S.
     Enhanced invasiveness of drug-resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase-2
     Int J Cancer125, 1074-1081. PubMed  Europe PubMed DOI
309. Tao,P., Fisher,J.F., Shi,Q., Vreven,T., Mobashery,S. and Schlegel,H.B.
     Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue
     Biochemistry48, 9839-9847. PubMed  Europe PubMed DOI  I
310. Tao,P., Fisher,J.F., Mobashery,S. and Schlegel,H.B.
     DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2
     Org Lett11, 2559-2562. PubMed  Europe PubMed DOI  I
311. Tuysuz,B., Mosig,R., Altun,G., Sancak,S., Glucksman,M.J. and Martignetti,J.A.
     A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects
     Eur J Hum Genet17, 565-572. PubMed  Europe PubMed DOI  M
312. Viappiani,S., Nicolescu,A.C., Holt,A., Sawicki,G., Crawford,B.D., Leon,H., van Mulligen,T. and Schulz,R.
     Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione
     Biochem Pharmacol77, 826-834. PubMed  Europe PubMed DOI
313. Wang,W., Shao,R., Wu,Q., Ke,S., McMurray,J., Lang,F.F., Jr., Charnsangavej,C., Gelovani,J.G. and Li,C.
     Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide
     Mol Imaging Biol11, 424-433. PubMed  Europe PubMed DOI  L  I
314. Xu,X., Mikhailova,M., Ilangovan,U., Chen,Z., Yu,A., Pal,S., Hinck,A.P. and Steffensen,B.
     Nuclear magnetic resonance mapping and functional confirmation of the collagen binding sites of matrix metalloproteinase-2
     Biochemistry48, 5822-5831. PubMed  Europe PubMed DOI
315. Zhi,Y.H., Song,M.M., Wang,P.L., Zhang,T. and Yin,Z.Y.
     Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion
     World J Gastroenterol15, 1072-1078. PubMed  Europe PubMed DOI  T
2008
316. Celenza,G., Villegas-Estrada,A., Lee,M., Boggess,B., Forbes,C., Wolter,W.R., Suckow,M.A., Mobashery,S. and Chang,M.
     Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor
     Chem Biol Drug Des71, 187-196. PubMed  Europe PubMed DOI  I
317. Cheng,X.C., Wang,Q., Fang,H., Tang,W. and Xu,W.F.
     Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors
     Eur J Med Chem43, 2130-2139. PubMed  Europe PubMed DOI  I
318. Diaz,N. and Suarez,D.
     Peptide hydrolysis catalyzed by matrix metalloproteinase 2: a computational study
     J Phys Chem B112, 8412-8424. PubMed  Europe PubMed DOI
319. Diaz,N., Suarez,D. and Valdes,H.
     From the X-ray compact structure to the elongated form of the full-length MMP-2 enzyme in solution: a molecular dynamics study
     J Am Chem Soc130, 14070-14071. PubMed  Europe PubMed DOI  S
320. Fert-Bober,J., Leon,H., Sawicka,J., Basran,R.S., Devon,R.M., Schulz,R. and Sawicki,G.
     Inhibiting matrix metalloproteinase-2 reduces protein release into coronary effluent from isolated rat hearts during ischemia-reperfusion
     Basic Res Cardiol103, 431-443. PubMed  Europe PubMed DOI
321. Higashi,S. and Miyazaki,K.
     Identification of amino acid residues of the matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor
     J Biol Chem283, 10068-10078. PubMed  Europe PubMed DOI
322. Ingvarsen,S., Madsen,D.H., Hillig,T., Lund,L.R., Holmbeck,K., Behrendt,N. and Engelholm,L.H.
     Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
     Biol Chem389, 943-953. PubMed  Europe PubMed DOI
323. Lebel,R., Jastrzebska,B., Therriault,H., Cournoyer,M.M., McIntyre,J.O., Escher,E., Neugebauer,W., Paquette,B. and Lepage,M.
     Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model
     Magn Reson Med60, 1056-1065. PubMed  Europe PubMed DOI  L
324. Lee,M., Hesek,D., Shi,Q., Noll,B.C., Fisher,J.F., Chang,M. and Mobashery,S.
     Conformational analyses of thiirane-based gelatinase inhibitors
     Bioorg Med Chem Lett18, 3064-3067. PubMed  Europe PubMed DOI  I
325. Mukai,T., Suganuma,N., Soejima,K., Sasaki,J., Yamamoto,F. and Maeda,M.
     Synthesis of a beta-tetrapeptide analog as a mother compound for the development of matrix metalloproteinase-2-imaging agents
     Chem Pharm Bull (Tokyo)56, 260-265. PubMed  Europe PubMed DOI  L  I
326. Naidu,D.G., Tang,M. and Tabibzadeh,S.
     Lefty peptides, derived by MMP2 cleavage, act as a new class of gelatinase A inhibitor
     Front Biosci13, 7193-7201. PubMed  Europe PubMed
327. Nishida,Y., Miyamori,H., Thompson,E.W., Takino,T., Endo,Y. and Sato,H.
     Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2
     Cancer Res68, 9096-9104. PubMed  Europe PubMed DOI
328. Rehault-Godbert,S., Gautron,J., Labas,V., Belghazi,M. and Nys,Y.
     Identification and characterization of the precursor of chicken matrix metalloprotease 2 (pro-MMP-2) in hen egg
     J Agric Food Chem56, 6294-6303. PubMed  Europe PubMed DOI
329. Tsung,A.J., Kargiotis,O., Chetty,C., Lakka,S.S., Gujrati,M., Spomar,D.G., Dinh,D.H. and Rao,J.S.
     Downregulation of matrix metalloproteinase-2 (MMP-2) utilizing adenovirus-mediated transfer of small interfering RNA (siRNA) in a novel spinal metastatic melanoma model
     Int J Oncol32, 557-564. PubMed  Europe PubMed
330. Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Wilson,L.J., Karnachi,P., Rhodes,K.J., Lagu,B. and Murray,W.V.
     beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. design, synthesis, and lead identification
     Bioorg Med Chem Lett18, 1135-1139. PubMed  Europe PubMed DOI  I
331. Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Huang,Z., Karnachi,P., Wilson,L.J., Rhodes,K.J., Lagu,B. and Murray,W.V.
     beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents
     Bioorg Med Chem Lett18, 1140-1145. PubMed  Europe PubMed DOI  I
332. Zheng,J., Wen,R. and Guillaume,D.
     Three-dimensional quantitative structure-activity relationship (CoMFA and CoMSIA) studies on galardin derivatives as gelatinase A (matrix metalloproteinase 2) inhibitors
     J Enzyme Inhib Med Chem23, 445-453. PubMed  Europe PubMed DOI  I
2007
333. Baraldo,S., Bazzan,E., Zanin,M.E., Turato,G., Garbisa,S., Maestrelli,P., Papi,A., Miniati,M., Fabbri,L.M., Zuin,R. and Saetta,M.
     Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression
     Chest132, 1733-1740. PubMed  Europe PubMed DOI
334. de Oliveira,C.A., Zissen,M., Mongon,J. and McCammon,J.A.
     Molecular dynamics simulations of metalloproteinases types 2 and 3 reveal differences in the dynamic behavior of the S1' binding pocket
     Curr Pharm Des13, 3471-3475. PubMed  Europe PubMed DOI  I
335. Diaz,N. and Suarez,D.
     Molecular dynamics simulations of matrix metalloproteinase 2: role of the structural metal ions
     Biochemistry46, 8943-8952. PubMed  Europe PubMed DOI
336. Egeblad,M., Shen,H.C., Behonick,D.J., Wilmes,L., Eichten,A., Korets,L.V., Kheradmand,F., Werb,Z. and Coussens,L.M.
     Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development
     Dev Dyn236, 1683-1693. PubMed  Europe PubMed DOI  K  M
337. Gioia,M., Monaco,S., Fasciglione,G.F., Coletti,A., Modesti,A., Marini,S. and Coletta,M.
     Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains
     J Mol Biol368, 1101-1113. PubMed  Europe PubMed DOI
338. Hanaoka,H., Mukai,T., Habashita,S., Asano,D., Ogawa,K., Kuroda,Y., Akizawa,H., Iida,Y., Endo,K., Saga,T. and Saji,H.
     Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors
     Nucl Med Biol34, 503-510. PubMed  Europe PubMed DOI  L  I
339. Hasebe,T., Hartman,R., Fu,L., Amano,T. and Shi,Y.B.
     Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development
     Mech Dev124, 11-22. PubMed  Europe PubMed DOI
340. Hayashi,R., Jin,X. and Cook,G.R.
     Synthesis and evaluation of novel heterocyclic MMP inhibitors
     Bioorg Med Chem Lett17, 6864-6870. PubMed  Europe PubMed DOI  I
341. Iida,J., Wilhelmson,K.L., Ng,J., Lee,P., Morrison,C., Tam,E., Overall,C.M. and McCarthy,J.B.
     Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A)
     Biochem J403, 553-563. PubMed  Europe PubMed DOI
342. Lauer-Fields,J., Brew,K., Whitehead,J.K., Li,S., Hammer,R.P. and Fields,G.B.
     Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors
     J Am Chem Soc129, 10408-10417. PubMed  Europe PubMed DOI  I
343. Lee,M., Villegas-Estrada,A., Celenza,G., Boggess,B., Toth,M., Kreitinger,G., Forbes,C., Fridman,R., Mobashery,S. and Chang,M.
     Metabolism of a highly selective gelatinase inhibitor generates active metabolite
     Chem Biol Drug Des70, 371-382. PubMed  Europe PubMed DOI  I
344. Monaco,S., Gioia,M., Rodriguez,J., Fasciglione,G.F., Di Pierro,D., Lupidi,G., Krippahl,L., Marini,S. and Coletta,M.
     Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen
     Biochem J402, 503-513. PubMed  Europe PubMed DOI
345. Mosig,R.A., Dowling,O., DiFeo,A., Ramirez,M.C., Parker,I.C., Abe,E., Diouri,J., Aqeel,A.A., Wylie,J.D., Oblander,S.A., Madri,J., Bianco,P., Apte,S.S., Zaidi,M., Doty,S.B., Majeska,R.J., Schaffler,M.B. and Martignetti,J.A.
     Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth
     Hum Mol Genet16, 1113-1123. PubMed  Europe PubMed DOI  K  M
346. Taniwaki,K., Fukamachi,H., Komori,K., Ohtake,Y., Nonaka,T., Sakamoto,T., Shiomi,T., Okada,Y., Itoh,T., Itohara,S., Seiki,M. and Yana,I.
     Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice
     Cancer Res67, 4311-4319. PubMed  Europe PubMed DOI
347. Tsukamoto,H., Yokoyama,Y., Suzuki,T., Mizuta,S. and Yoshinaka,R.
     Molecular cloning and expression of gelatinases (MMP-2 and MMP-9) in the pufferfish Takifugu rubripes
     Comp Biochem Physiol B Biochem Mol Biol148, 295-302. PubMed  Europe PubMed DOI
2006
348. [YEAR:30-10-2006]Bellosta,S., Gomaraschi,M., Canavesi,M., Rossoni,G., Monetti,M., Franceschini,G. and Calabresi,L.
     Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection
     FEBS Lett580, 5974-5978. PubMed  Europe PubMed DOI  T
349. [YEAR:4-8-2006]Cheng,S., Pollock,A.S., Mahimkar,R., Olson,J.L. and Lovett,D.H.
     Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury
     FASEB J20, 1898-1900. PubMed  Europe PubMed DOI  T
350. Greenlee,K.J., Corry,D.B., Engler,D.A., Matsunami,R.K., Tessier,P., Cook,R.G., Werb,Z. and Kheradmand,F.
     Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation
     J Immunol177, 7312-7321. PubMed  Europe PubMed
351. [YEAR:18-1-2006]Hasebe,T., Hartman,R., Matsuda,H. and Shi,Y.B.
     Spatial and temporal expression profiles suggest the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis
     Cell Tissue Res324, 105-116. PubMed  Europe PubMed DOI
352. [YEAR:27-2-2006]Matsusaka,H., Ide,T., Matsushima,S., Ikeuchi,M., Kubota,T., Sunagawa,K., Kinugawa,S. and Tsutsui,H.
     Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload
     Hypertension47, 711-717. PubMed  Europe PubMed DOI  K
353. Monaco,S., Sparano,V., Gioia,M., Sbardella,D., Di Pierro,D., Marini,S. and Coletta,M.
     Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains
     Protein Sci15, 2805-2815. PubMed  Europe PubMed DOI
354. [YEAR:28-9-2006]Nakaji,K., Ihara,M., Takahashi,C., Itohara,S., Noda,M., Takahashi,R. and Tomimoto,H.
     Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents
     Stroke37, 2816-2823. PubMed  Europe PubMed DOI  T  I
355. Thompson,M. and Cockerill,G.
     Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis
     Ann N Y Acad Sci1085, 170-174. PubMed  Europe PubMed DOI
356. [YEAR:14-2-2006]Tuccinardi,T., Martinelli,A., Nuti,E., Carelli,P., Balzano,F., Uccello-Barretta,G., Murphy,G. and Rossello,A.
     Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides
     Bioorg Med Chem14, 4260-4276. PubMed  Europe PubMed DOI  I
357. [YEAR:7-6-2006]Yamamoto,S., Nakatani,S., Ikura,M., Sugiura,T., Nishita,Y., Itadani,S., Ogawa,K., Ohno,H., Takahashi,K., Nakai,H. and Toda,M.
     Design and synthesis of an orally active matrix metalloproteinase inhibitor
     Bioorg Med Chem14, 6383-6403. PubMed  Europe PubMed DOI  I
358. [YEAR:26-9-2006]Zhang,L., Zhang,J., Fang,H., Wang,Q. and Xu,W.
     Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors
     Bioorg Med Chem14, 8286-8294. PubMed  Europe PubMed DOI  I
2005
359. Agamennone,M., Campestre,C., Preziuso,S., Consalvi,V., Crucianelli,M., Mazza,F., Politi,V., Ragno,R., Tortorella,P. and Gallina,C.
     Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2
     Eur J Med Chem40, 271-279. PubMed  Europe PubMed DOI  I
360. Al-Aqeel,A.I.
     Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene
     Saudi Med J26, 24-30. PubMed  Europe PubMed  M
361. Ben-Yosef,Y., Miller,A., Shapiro,S. and Lahat,N.
     Hypoxia of endothelial cells leads to MMP-2-dependent survival and death
     Am J Physiol Cell Physiol289, C1321-C1331. PubMed  Europe PubMed DOI
362. [YEAR:31-5-2005]Bianchini,G., Aschi,M., Cavicchio,G., Crucianelli,M., Preziuso,S., Gallina,C., Nastari,A., Gavuzzo,E. and Mazza,F.
     Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8
     Bioorg Med Chem13, 4740-4749. PubMed  Europe PubMed DOI  I
363. [YEAR:6-1-2005]Cao,J., Rehemtulla,A., Pavlaki,M., Kozarekar,P. and Chiarelli,C.
     Furin directly cleaves proMMP-2 in the trans-golgi network resulting in a nonfunctioning proteinase
     J Biol Chem280, 10974-10980. PubMed  Europe PubMed DOI
364. [YEAR:29-9-2005]Lee,M., Bernardo,M.M., Meroueh,S.O., Brown,S., Fridman,R. and Mobashery,S.
     Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors
     Org Lett7, 4463-4465. PubMed  Europe PubMed DOI  I
365. [YEAR:22-7-2005]Lindstad,R.I., Sylte,I., Mikalsen,S.O., Seglen,P.O., Berg,E. and Winberg,J.O.
     Pancreatic trypsin activates human promatrix metalloproteinase-2
     J Mol Biol350, 682-698. PubMed  Europe PubMed DOI
366. [YEAR:3-6-2005]Matsusaka,H., Ikeuchi,M., Matsushima,S., Ide,T., Kubota,T., Feldman,A.M., Takeshita,A., Sunagawa,K. and Tsutsui,H.
     Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy
     Am J Physiol Heart Circ Physiol289, H1858-H1864. PubMed  Europe PubMed DOI
367. Oblander,S.A., Zhou,Z., Galvez,B.G., Starcher,B., Shannon,J.M., Durbeej,M., Arroyo,A.G., Tryggvason,K. and Apte,S.S.
     Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation
     Dev Biol277, 255-269. PubMed  Europe PubMed DOI
368. [YEAR:1-3-2005]Rossello,A., Nuti,E., Carelli,P., Orlandini,E., Macchia,M., Nencetti,S., Zandomeneghi,M., Balzano,F., Uccello Barretta,G., Albini,A., Benelli,R., Cercignani,G., Murphy,G. and Balsamo,A.
     N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP
     Bioorg Med Chem Lett15, 1321-1326. PubMed  Europe PubMed DOI  I
369. [YEAR:26-7-2005]Sawicki,G., Leon,H., Sawicka,J., Sariahmetoglu,M., Schulze,C.J., Scott,P.G., Szczesna-Cordary,D. and Schulz,R.
     Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2
     Circulation112, 544-552. PubMed  Europe PubMed DOI
370. [YEAR:10-3-2005]Wang,F.Q., So,J., Reierstad,S. and Fishman,D.A.
     Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase
     Int J Cancer114, 19-31. PubMed  Europe PubMed DOI
371. [YEAR:12-7-2005]Xu,X., Chen,Z., Wang,Y., Yamada,Y. and Steffensen,B.
     Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2
     Biochem J392, 127-134. PubMed  Europe PubMed DOI
372. Zankl,A., Bonafe,L., Calcaterra,V., Di Rocco,M. and Superti-Furga,A.
     Winchester syndrome caused by a homozygous mutation affecting the active site of matrix metalloproteinase 2
     Clin Genet67, 261-266. PubMed  Europe PubMed DOI  M
2004
373. [YEAR:21-9-2004]Belkin,A.M., Zemskov,E.A., Hang,J., Akimov,S.S., Sikora,S. and Strongin,A.Y.
     Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis
     Biochemistry43, 11760-11769. PubMed  Europe PubMed DOI
374. [YEAR:19-1-2004]Butler,G.S., Tam,E.M. and Overall,C.M.
     The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily
     J Biol Chem279, 15615-15620. PubMed  Europe PubMed DOI  I
375. Duong,T.D. and Erickson,C.A.
     MMP-2 plays an essential role in producing epithelial-mesenchymal transformations in the avian embryo
     Dev Dyn229, 42-53. PubMed  Europe PubMed DOI
376. Grieu,F., Li,W.Q. and Iacopetta,B.
     Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype
     Breast Cancer Res Treat88, 197-204. PubMed  Europe PubMed DOI  M
377. [YEAR:6-2-2004]Kwan,J.A., Schulze,C.J., Wang,W., Leon,H., Sariahmetoglu,M., Sung,M., Sawicka,J., Sims,D.E., Sawicki,G. and Schulz,R.
     Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro
     FASEB J18, 690-692. PubMed  Europe PubMed DOI
378. [YEAR:17-8-2004]Ma,Z., Chang,M.J., Shah,R., Adamski,J., Zhao,X. and Benveniste,E.N.
     Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene
     J Biol Chem279, 46326-46334. PubMed  Europe PubMed DOI
379. [YEAR:1-11-2004]Martinez,A., Oh,H.R., Unsworth,E.J., Bregonzio,C., Saavedra,J.M., Stetler-Stevenson,W.G. and Cuttitta,F.
     Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator
     Biochem J383, 413-418. PubMed  Europe PubMed DOI
380. Murphy,G.
     Gelatinase A
     [ISSN:0-12-079610-4]2, 497-503.  V
381. [YEAR:28-9-2004]Oak,M.H., El Bedoui,J., Anglard,P. and Schini-Kerth,V.B.
     Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells
     Circulation110, 1861-1867. PubMed  Europe PubMed DOI
382. [YEAR:5-4-2004]Oh,J., Takahashi,R., Adachi,E., Kondo,S., Kuratomi,S., Noma,A., Alexander,D.B., Motoda,H., Okada,A., Seiki,M., Itoh,T., Itohara,S., Takahashi,C. and Noda,M.
     Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice
     Oncogene23, 5041-5048. PubMed  Europe PubMed DOI  K
383. [YEAR:1-5-2004]Rossello,A., Nuti,E., Orlandini,E., Carelli,P., Rapposelli,S., Macchia,M., Minutolo,F., Carbonaro,L., Albini,A., Benelli,R., Cercignani,G., Murphy,G. and Balsamo,A.
     New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)
     Bioorg Med Chem12, 2441-2450. PubMed  Europe PubMed DOI  I
384. Svab,I., Alexandru,D., Vitos,G. and Flonta,M.L.
     Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method
     J Cell Mol Med8, 551-562. PubMed  Europe PubMed  I
385. [YEAR:19-11-2004]Xu,E., Lai,M., Lv,B., Xing,X., Huang,Q. and Xia,X.
     A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer
     Biochem Biophys Res Commun324, 999-1003. PubMed  Europe PubMed DOI  M
386. [YEAR:21-2-2004]Zhang,W., Hou,T.J., Qiao,X.B., Huai,S. and Xu,X.J.
     Binding affinity of hydroxamate inhibitors of matrix metalloproteinase-2
     J Mol Model10, 112-120. PubMed  Europe PubMed DOI  I
387. [YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R.
     Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation
     J Biol Chem279, 8592-8601. PubMed  Europe PubMed DOI  I
2003
388. [YEAR:19-5-2003]Auge,F., Hornebeck,W., Decarme,M. and Laronze,J.Y.
     Improved gelatinase A selectivity by novel zinc binding groups containing galardin derivatives
     Bioorg Med Chem Lett13, 1783-1786. PubMed  Europe PubMed DOI  I
389. Chen,E.I., Li,W., Godzik,A., Howard,E.W. and Smith,J.W.
     A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9
     J Biol Chem278, 17158-17163. PubMed  Europe PubMed DOI
390. Cheng,D., Shen,Q., Nan,F., Qian,Z. and Ye,Q.Z.
     Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for high-throughput inhibitor screening
     Protein Expr Purif27, 63-74. PubMed  Europe PubMed DOI  I
391. Cheng,S. and Lovett,D.H.
     Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation
     Am J Pathol162, 1937-1949. PubMed  Europe PubMed DOI
392. [YEAR:7-2-2003]Deshane,J., Garner,C.C. and Sontheimer,H.
     Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2
     J Biol Chem278, 4135-4144. PubMed  Europe PubMed DOI
393. [YEAR:6-6-2003]Harendza,S., Lovett,D.H., Panzer,U., Lukacs,Z., Kuhnl,P. and Stahl,R.A.
     Linked common polymorphisms in the gelatinase A promoter are associated with diminished transcriptional response to estrogen and genetic fitness
     J Biol Chem278, 20490-20499. PubMed  Europe PubMed DOI  M
394. Hayashidani,S., Tsutsui,H., Ikeuchi,M., Shiomi,T., Matsusaka,H., Kubota,T., Imanaka-Yoshida,K., Itoh,T. and Takeshita,A.
     Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction
     Am J Physiol Heart Circ Physiol285, H1229-H1235. PubMed  Europe PubMed DOI
395. [YEAR:18-4-2003]Higashi,S. and Miyazaki,K.
     Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity
     J Biol Chem278, 14020-14028. PubMed  Europe PubMed DOI
396. [YEAR:3-6-2003]Higashi,S. and Miyazaki,K.
     Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase A
     Biochemistry42, 6514-6526. PubMed  Europe PubMed DOI
397. [YEAR:23-10-2003]Lafleur,M.A., Tester,A.M. and Thompson,E.W.
     Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism
     FEBS Lett553, 457-463. PubMed  Europe PubMed DOI
398. Lauer-Fields,J.L., Sritharan,T., Stack,M.S., Nagase,H. and Fields,G.B.
     Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9
     J Biol Chem278, 18140-18145. PubMed  Europe PubMed DOI
399. [YEAR:15-7-2003]Miao,X., Yu,C., Tan,W., Xiong,P., Liang,G., Lu,W. and Lin,D.
     A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma
     Cancer Res63, 3987-3990. PubMed  Europe PubMed  M
400. Ohno-Matsui,K., Uetama,T., Yoshida,T., Hayano,M., Itoh,T., Morita,I. and Mochizuki,M.
     Reduced retinal angiogenesis in MMP-2-deficient mice
     Invest Ophthalmol Vis Sci44, 5370-5375. PubMed  Europe PubMed DOI  K
401. [YEAR:18-7-2003]Rosenblum,G., Meroueh,S.O., Kleifeld,O., Brown,S., Singson,S.P., Fridman,R., Mobashery,S. and Sagi,I.
     Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2)
     J Biol Chem278, 27009-27015. PubMed  Europe PubMed DOI
402. [YEAR:4-4-2003]Trexler,M., Briknarova,K., Gehrmann,M., Llinas,M. and Patthy,L.
     Peptide ligands for the fibronectin type II modules of matrix metalloproteinase 2 (MMP-2)
     J Biol Chem278, 12241-12246. PubMed  Europe PubMed DOI
403. Vasku,A., Goldbergova,M., Holla,L.I., Spinarova,L., Spinar,J., Vitovec,J. and Vacha,J.
     Two MMP-2 promoter polymorphisms (-790T/G and -735C/T) in chronic heart failure
     Clin Chem Lab Med41, 1299-1303. PubMed  Europe PubMed DOI  M
404. Zhang,K., McQuibban,G.A., Silva,C., Butler,G.S., Johnston,J.B., Holden,J., Clark-Lewis,I., Overall,C.M. and Power,C.
     HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration
     Nat Neurosci6, 1064-1071. PubMed  Europe PubMed DOI
2002
405. [YEAR:3-5-2002]Bannikov,G.A., Karelina,T.V., Collier,I.E., Marmer,B.L. and Goldberg,G.I.
     Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide
     J Biol Chem277, 16022-16027. PubMed  Europe PubMed DOI
406. [YEAR:8-2-2002]Chen,E.I., Kridel,S.J., Howard,E.W., Li,W., Godzik,A. and Smith,J.W.
     A unique substrate recognition profile for matrix metalloproteinase-2
     J Biol Chem277, 4485-4491. PubMed  Europe PubMed DOI
407. [YEAR:29-7-2002]Feng,Y., Likos,J.J., Zhu,L., Woodward,H., Munie,G., McDonald,J.J., Stevens,A.M., Howard,C.P., De Crescenzo,G.A., Welsch,D., Shieh,H.S. and Stallings,W.C.
     Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor
     Biochim Biophys Acta1598, 10-23. PubMed  Europe PubMed  S  I
408. Gehrmann,M., Briknarova,K., Banyai,L., Patthy,L. and Llinas,M.
     The col-1 module of human matrix metalloproteinase-2 (MMP-2): Structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains
     Biol Chem383, 137-148. PubMed  Europe PubMed DOI
409. Longo,G.M., Xiong,W., Greiner,T.C., Zhao,Y., Fiotti,N. and Baxter,B.T.
     Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms
     J Clin Invest110, 625-632. PubMed  Europe PubMed DOI
410. [YEAR:28-5-2002]Morgunova,E., Tuuttila,A., Bergmann,U. and Tryggvason,K.
     Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
     Proc Natl Acad Sci U S A99, 7414-7419. PubMed  Europe PubMed DOI  S
2001
411. 
     Sulfone reverse hydroxamates as matrix metalloproteinase inhibitors
     Expert Opin Ther Pat11, 133-143. DOI  V  I
412. [YEAR:2-3-2001]Atkinson,S.J., Patterson,M.L., Butler,M.J. and Murphy,G.
     Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model
     FEBS Lett491, 222-226. PubMed  Europe PubMed DOI
413. [YEAR:8-6-2001]Berton,A., Rigot,V., Huet,E., Decarme,M., Eeckhout,Y., Patthy,L., Godeau,G., Hornebeck,W., Bellon,G. and Emonard,H.
     Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids
     J Biol Chem276, 20458-20465. PubMed  Europe PubMed DOI  I
414. [YEAR:20-7-2001]Briknarova,K., Gehrmann,M., Banyai,L., Tordai,H., Patthy,L. and Llinas,M.
     Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct
     J Biol Chem276, 27613-27621. PubMed  Europe PubMed DOI
415. Chen,J.M., Fortunato,M., Stevens,R.A.E. and Barrett,A.J.
     Activation of progelatinase A by mammalian legumain, a recently discovered cysteine proteinase
     Biol Chem382, 777-783. PubMed  Europe PubMed DOI
416. [YEAR:15-2-2001]Deryugina,E.I., Ratnikov,B., Monosov,E., Postnova,T.I., DiScipio,R., Smith,J.W. and Strongin,A.Y.
     MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells
     Exp Cell Res263, 209-223. PubMed  Europe PubMed DOI
417. Fray,M.J., Burslem,M.F. and Dickinson,R.P.
     Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality
     Bioorg Med Chem Lett11, 567-570. PubMed  Europe PubMed DOI  I
418. Han,Y.P., Tuan,T.L., Wu,H., Hughes,M. and Garner,W.L.
     TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP
     J Cell Sci114, 131-139. PubMed  Europe PubMed
419. Ihara,M., Tomimoto,H., Kinoshita,M., Oh,J., Noda,M., Wakita,H., Akiguchi,I. and Shibasaki,H.
     Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter
     J Cereb Blood Flow Metab21, 828-834. PubMed  Europe PubMed DOI
420. [YEAR:3-9-2001]Itoh,Y., Takamura,A., Ito,N., Maru,Y., Sato,H., Suenaga,N., Aoki,T. and Seiki,M.
     Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
     EMBO J20, 4782-4793. PubMed  Europe PubMed DOI
421. Jackson,C., Nguyen,M., Arkell,J. and Sambrook,P.
     Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - Targetting gelatinase A activation
     Inflamm Res50, 183-186. PubMed  Europe PubMed DOI
422. [YEAR:18-5-2001]Kleifeld,O., Kotra,L.P., Gervasi,D.C., Brown,S., Bernardo,M.M., Fridman,R., Mobashery,S. and Sagi,I.
     X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. Comparison with the latent and active forms of the enzyme
     J Biol Chem276, 17125-17131. PubMed  Europe PubMed DOI  S  I
423. Kraft,P.J., Haynes-Johnson,D.E., Patel,L., Lenhart,J.A., Zivin,R.A. and Palmer,S.S.
     Fluorescence polarization assay and SDS-PAGE confirms matrilysin degrades fibronectin and collagen IV whereas gelatinase a degrades collagen IV but not fibronectin
     Connect Tissue Res42, 149-163. PubMed  Europe PubMed
424. [YEAR:1-7-2001]Lafleur,M.A., Hollenberg,M.D., Atkinson,S.J., Knauper,V., Murphy,G. and Edwards,D.R.
     Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species
     Biochem J357, 107-115. PubMed  Europe PubMed DOI
425. Lijnen,H.R., Maquoi,E., Holvoet,P., Mertens,A., Lupu,F., Morange,P., Alessi,M.C. and Juhan-Vague,I.
     Adipose tissue expression of gelatinases in mouse models of obesity
     Thromb Haemost85, 1111-1116. PubMed  Europe PubMed
426. Martignetti,J.A., Aqeel,A.A., Sewairi,W.A., Boumah,C.E., Kambouris,M., Mayouf,S.A., Sheth,K.V., Eid,W.A., Dowling,O., Harris,J., Glucksman,M.J., Bahabri,S., Meyer,B.F. and Desnick,R.J.
     Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome
     Nat Genet28, 261-265. PubMed  Europe PubMed DOI
427. [YEAR:15-5-2001]Medina,O.P., Soderlund,T., Laakkonen,L.J., Tuominen,E.K., Koivunen,E. and Kinnunen,P.K.
     Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro
     Cancer Res61, 3978-3985. PubMed  Europe PubMed  I
428. [YEAR:14-12-2001]Morrison,C.J., Butler,G.S., Bigg,H.F., Roberts,C.R., Soloway,P.D. and Overall,C.M.
     Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway
     J Biol Chem276, 47402-47410. PubMed  Europe PubMed DOI
429. Natchus,M.G., Bookland,R.G., Laufersweiler,M.J., Pikul,S., Almstead,N.G., De,B., Janusz,M.J., Hsieh,L.C., Gu,F., Pokross,M.E., Patel,V.S., Garver,S.M., Peng,S.X., Branch,T.M., King,S.L., Baker,T.R., Foltz,D.J. and Mieling,G.E.
     Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines
     J Med Chem44, 1060-1071. PubMed  Europe PubMed DOI  I
430. [YEAR:17-8-2001]Patterson,M.L., Atkinson,S.J., Knauper,V. and Murphy,G.
     Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain
     FEBS Lett503, 158-162. PubMed  Europe PubMed DOI
431. [YEAR:6-4-2001]Pekovich,S.R., Bock,P.E. and Hoover,R.L.
     Thrombin-thrombomodulin activation of protein C facilitates the activation of progelatinase A
     FEBS Lett494, 129-132. PubMed  Europe PubMed DOI
432. [YEAR:9-3-2001]Price,S.J., Greaves,D.R. and Watkins,H.
     Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation
     J Biol Chem276, 7549-7558. PubMed  Europe PubMed DOI  M
433. [YEAR:1-1-2001]Puyraimond,A., Fridman,R., Lemesle,M., Arbeille,B. and Menashi,S.
     MMP-2 colocalizes with caveolae on the surface of endothelial cells
     Exp Cell Res262, 28-36. PubMed  Europe PubMed DOI
434. Ruangpanit,N., Chan,D., Holmbeck,K., Birkedal-Hansen,H., Polarek,J., Yang,C., Bateman,J.F. and Thompson,E.W.
     Gelatinase A (MMP-2) activation by skin fibroblasts: dependence on MT1-MMP expression and fibrillar collagen form
     Matrix Biol20, 193-203. PubMed  Europe PubMed DOI
435. Shamamian,P., Schwartz,J.D., Pocock,B.J., Monea,S., Whiting,D., Marcus,S.G. and Mignatti,P.
     Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: A role for inflammatory cells in tumor invasion and angiogenesis
     J Cell Physiol189, 197-206. PubMed  Europe PubMed DOI
436. [YEAR:16-3-2001]Yang,Z., Strickland,D.K. and Bornstein,P.
     Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2
     J Biol Chem276, 8403-8408. PubMed  Europe PubMed DOI
2000
437. [YEAR:25-8-2000]Caterina,J.J., Yamada,S., Caterina,N.C., Longenecker,G., Holmback,K., Shi,J., Yermovsky,A.E., Engler,J.A. and Birkedal-Hansen,H.
     Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2 (Timp-2) gene alters proMMP-2 activation
     J Biol Chem275, 26416-26422. PubMed  Europe PubMed DOI
438. Fasciglione,G.F., Marini,S., D'Alessio,S., Politi,V. and Coletta,M.
     pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B
     Biophys J79, 2138-2149. PubMed  Europe PubMed DOI
439. [YEAR:20-9-2000]Gingras,D., Page,M., Annabi,B. and Beliveau,R.
     Rapid activation of matrix metalloproteinase-2 by glioma cells occurs through a posttranslational MT1-MMP-dependent mechanism
     Biochim Biophys Acta1497, 341-350. PubMed  Europe PubMed DOI
440. [YEAR:18-8-2000]McQuibban,G.A., Gong,J.H., Tam,E.M., McCulloch,C.A., Clark-Lewis,I. and Overall,C.M.
     Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
     Science289, 1202-1206. PubMed  Europe PubMed DOI
441. [YEAR:15-12-2000]Overall,C.M., Tam,E., McQuibban,G.A., Morrison,C., Wallon,U.M., Bigg,H.F., King,A.E. and Roberts,C.R.
     Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation
     J Biol Chem275, 39497-39506. PubMed  Europe PubMed DOI
1999
442. [YEAR:15-10-1999]Briknarova,K., Grishaev,A., Banyai,L., Tordai,H., Patthy,L. and Llinas,M.
     The second type II module from human matrix metalloproteinase 2: structure, function and dynamics
     Structure7, 1235-1245. PubMed  Europe PubMed DOI
443. [YEAR:16-4-1999]Butler,G.S., Apte,S.S., Willenbrock,F. and Murphy,G.
     Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions
     J Biol Chem274, 10846-10851. PubMed  Europe PubMed DOI
444. [YEAR:12-11-1999]Fernandez-Patron,C., Radomski,M.W. and Davidge,S.T.
     Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor
     Circ Res85, 906-911. PubMed  Europe PubMed
445. [YEAR:25-8-1999]Makela,M., Larjava,H., Pirila,E., Maisi,P., Salo,T., Sorsa,T. and Uitto,V.J.
     Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes
     Exp Cell Res251, 67-78. PubMed  Europe PubMed DOI  I
446. [YEAR:4-6-1999]Morgunova,E., Tuuttila,A., Bergmann,U., Isupov,M., Lindqvist,Y., Schneider,G. and Tryggvason,K.
     Structure of human pro-matrix metalloproteinase-2: Activation mechanism revealed
     Science284, 1667-1670. PubMed  Europe PubMed DOI  S
447. Nguyen,M., Arkell,J. and Jackson,C.J.
     Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells via a mechanism independent of active MT1 matrix metalloproteinase
     Lab Invest79, 467-475. PubMed  Europe PubMed
448. [YEAR:12-2-1999]Overall,C.M., King,A.E., Sam,D.K., Ong,A.D., Lau,T.T., Wallon,U.M., DeClerck,Y.A. and Atherstone,J.
     Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV
     J Biol Chem274, 4421-4429. PubMed  Europe PubMed DOI
449. [YEAR:30-7-1999]Passi,A., Negrini,D., Albertini,R., Miserocchi,G. and De Luca,G.
     The sensitivity of versican from rabbit lung to gelatinase A (MMP-2) and B (MMP-9) and its involvement in the development of hydraulic lung edema
     FEBS Lett456, 93-96. PubMed  Europe PubMed DOI
1998
450. [YEAR:9-1-1998]Butler,G.S., Butler,M.J., Atkinson,S.J., Will,H., Tamura,T., Schade van Westrum,S., Crabbe,T., Clements,J., d'Ortho,M.P. and Murphy,G.
     The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study
     J Biol Chem273, 871-880. PubMed  Europe PubMed DOI
451. [YEAR:15-7-1998]Farina,A.R., Tacconelli,A., Teti,A., Gulino,A. and Mackay,A.R.
     Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate
     Cancer Res58, 2957-2960. PubMed  Europe PubMed
452. [YEAR:19-6-1998]Ferry,G., Boutin,J.A., Hennig,P., Genton,A., Desmet,C., Fauchere,J.L., Atassi,G. and Tucker,G.C.
     A zinc chelator inhibiting gelatinases exerts potent in vitro anti-invasive effects
     Eur J Pharmacol351, 225-233. PubMed  Europe PubMed DOI  I
453. Hayashi,K., Osada,S., Shofuda,K., Horikoshi,S., Shirato,I. and Tomino,Y.
     Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis
     J Am Soc Nephrol9, 2262-2271. PubMed  Europe PubMed
454. [YEAR:14-7-1998]Hutton,M., Willenbrock,F., Brocklehurst,K. and Murphy,G.
     Kinetic analysis of the mechanism of interaction of full-length TIMP-2 and gelatinase A: Evidence for the existence of a low-affinity intermediate
     Biochemistry37, 10094-10098. PubMed  Europe PubMed DOI
455. [YEAR:1-3-1998]Itoh,T., Tanioka,M., Yoshida,H., Yoshioka,T., Nishimoto,H. and Itohara,S.
     Reduced angiogenesis and tumor progression in gelatinase A-deficient mice
     Cancer Res58, 1048-1051. PubMed  Europe PubMed
456. [YEAR:18-9-1998]Itoh,Y., Ito,A., Iwata,K., Tanzawa,K., Mori,Y. and Nagase,H.
     Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface
     J Biol Chem273, 24360-24367. PubMed  Europe PubMed DOI
457. [YEAR:26-6-1998]Kinoshita,T., Sato,H., Okada,A., Ohuchi,E., Imai,K., Okada,Y. and Seiki,M.
     TIMP-2 promotes activation of progelatinase a by membrane-type 1 matrix metalloproteinase immobilized on agarose beads
     J Biol Chem273, 16098-16103. PubMed  Europe PubMed DOI
458. [YEAR:1-9-1998]Lehti,K., Lohi,J., Valtanen,H. and Keski-Oja,J.
     Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface
     Biochem J334, 345-353. PubMed  Europe PubMed
459. Lijnen,H.R., Silence,J., Lemmens,G., Frederix,L. and Collen,D.
     Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system
     Thromb Haemost79, 1171-1176. PubMed  Europe PubMed
460. [YEAR:13-3-1998]Maquoi,E., Noel,A., Frankenne,F., Angliker,H., Murphy,G. and Foidart,J.M.
     Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor
     FEBS Lett424, 262-266. PubMed  Europe PubMed DOI  I
461. Xuan,J.W., Tuck,A.B., Wilson,S.M., Chin,J.L. and Chambers,A.F.
     MMP-2 expression is associated with, but not sufficient for, malignant conversion of murine LTA cells
     Anticancer Res18, 743-749. PubMed  Europe PubMed
1997
462. Bigg,H.F., Shi,Y.E., Liu,Y.E., Steffensen,B. and Overall,C.M.
     Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2
     J Biol Chem272, 15496-15500. PubMed  Europe PubMed DOI
463. Burns,E.H., Jr., Marciel,A.M. and Musser,J.M.
     Structure-function and pathogenesis studies of Streptococcus pyogenes extracellular cysteine protease
     Adv Exp Med Biol418, 589-592. PubMed  Europe PubMed
464. Deryugina,E.I., Luo,G.X., Reisfeld,R.A., Bourdon,M.A. and Strongin,A.
     Tumor cell invasion through Matrigel is regulated by activated matrix metalloproteinase-2
     Anticancer Res17, 3201-3210. PubMed  Europe PubMed
465. Kolkenbrock,H., Hecker-Kia,A., Orgel,D., Ulbrich,N. and Will,H.
     Activation of progelatinase A and progelatinase A/TIMP-2 complex by membrane type 2-matrix metalloproteinase
     Biol Chem378, 71-76. PubMed  Europe PubMed
466. Okada,A., Tomasetto,C., Lutz,Y., Bellocq,J.P., Rio,M.C. and Basset,P.
     Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A
     J Cell Biol137, 67-77. PubMed  Europe PubMed DOI
467. Quesada,A.R., Barbacid,M.M., Mira,E., Fernandez-Resa,P., Marquez,G. and Aracil,M.
     Evaluation of fluorometric and zymographic methods as activity assays for stromelysins and gelatinases
     Clin Exp Metastasis15, 26-32. PubMed  Europe PubMed DOI  A
468. Ueno,H., Nakamura,H., Inoue,M., Imai,K., Noguchi,M., Sato,H., Seiki,M. and Okada,Y.
     Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas
     Cancer Res57, 2055-2060. PubMed  Europe PubMed
1996
469. [YEAR:31-5-1996]Brooks,P.C., Stromblad,S., Sanders,L.C., von Schalscha,T.L., Aimes,R.T., Stetler-Stevenson,W.G., Quigley,J.P. and Cheresh,D.A.
     Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
     Cell85, 683-693. PubMed  Europe PubMed DOI
470. Fishman,D.A., Bafetti,L.M. and Stack,M.S.
     Membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation in primary human ovarian epithelial carcinoma cells
     Invasion Metastasis16, 150-159. PubMed  Europe PubMed
471. Gohlke,U., Gomis-Ruth,F.X., Crabbe,T., Murphy,G., Docherty,A.J. and Bode,W.
     The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function
     FEBS Lett378, 126-130. PubMed  Europe PubMed DOI
1995
472. Atkinson,S.J., Crabbe,T., Cowell,S., Ward,R.V., Butler,M.J., Sato,H., Seiki,M., Reynolds,J.J. and Murphy,G.
     Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes
     J Biol Chem270, 30479-30485. PubMed  Europe PubMed DOI
473. Chander,S.K., Antoniw,P., Beeley,N.R., Boyce,B., Crabbe,T., Docherty,A.J., Leonard,J., Mason,B., Millar,K. and Millican,A.T.
     An in vivo model for screening peptidomimetic inhibitors of gelatinase A
     J Pharm Sci84, 404-409. PubMed  Europe PubMed DOI  I
474. [YEAR:15-6-1995]Fridman,R., Toth,M., Pena,D. and Mobashery,S.
     Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)
     Cancer Res55, 2548-2555. PubMed  Europe PubMed
475. [YEAR:1-6-1995]Itoh,Y., Binner,S. and Nagase,H.
     Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate
     Biochem J308, 645-651. PubMed  Europe PubMed
476. Libson,A.M., Gittis,A.G., Collier,I.E., Marmer,B.L., Goldberg,G.I. and Lattman,E.E.
     Crystal structure of the haemopexin-like C-terminal domain of gelatinase A
     Nat Struct Biol2, 938-942. PubMed  Europe PubMed  S
477. Murphy,G. and Crabbe,T.
     Gelatinases A and B
     Methods Enzymol248, 470-484. PubMed  Europe PubMed DOI  V
1994
478. Aimes,R.T., French,D.L. and Quigley,J.P.
     Cloning of a 72 kDa matrix metalloproteinase (gelatinase) from chicken embryo fibroblasts using gene family PCR: Expression of the gelatinase increases upon malignant transformation
     Biochem J300, 729-736. PubMed  Europe PubMed
479. Brown,F.K., Brown,P.J., Bickett,D.M., Chambers,C.L., Davies,H.G., Deaton,D.N., Drewry,D., Foley,M., McElroy,A.B., Gregson,M., McGeehan,G.M., Myers,P.L., Norton,D., Salovich,J.M., Schoenen,F.J. and Ward,P.
     Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: modification of the P1 and P2' residues
     J Med Chem37, 674-688. PubMed  Europe PubMed  I
480. Crabbe,T., Zucker,S., Cockett,M.I., Willenbrock,F., Tickle,S., O'Connell,J.P., Scothern,J.M., Murphy,G. and Docherty,A.J.
     Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1
     Biochemistry33, 6684-6690. PubMed  Europe PubMed DOI
481. [YEAR:23-5-1994]Crabbe,T., Smith,B., O'Connell,J. and Docherty,A.
     Human progelatinase A can be activated by matrilysin
     FEBS Lett345, 14-16. PubMed  Europe PubMed DOI
482. Crabbe,T., O'Connell,J.P., Smith,B.J. and Docherty,A.J.
     Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A
     Biochemistry33, 14419-14425. PubMed  Europe PubMed
483. [YEAR:14-10-1994]Fowlkes,J.L., Enghild,J.J., Suzuki,K. and Nagase,H.
     Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures
     J Biol Chem269, 25742-25746. PubMed  Europe PubMed  P
484. [YEAR:1-11-1994]Monsky,W.L., Lin,C.Y., Aoyama,A., Kelly,T., Akiyama,S.K., Mueller,S.C. and Chen,W.T.
     A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells
     Cancer Res54, 5702-5710. PubMed  Europe PubMed
485. Nguyen,Q., Willenbrock,F., Cockett,M.I., O'Shea,M., Docherty,A.J. and Murphy,G.
     Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A
     Biochemistry33, 2089-2095. PubMed  Europe PubMed
486. [YEAR:29-11-1994]Ochieng,J., Fridman,R., Nangia-Makker,P., Kleiner,D.E., Liotta,L.A., Stetler-Stevenson,W.G. and Raz,A.
     Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9
     Biochemistry33, 14109-14114. PubMed  Europe PubMed DOI
487. Roher,A.E., Kasunic,T.C., Woods,A.S., Cotter,R.J., Ball,M.J. and Fridman,R.
     Proteolysis of Abeta peptide from Alzheimer disease brain by gelatinase A
     Biochem Biophys Res Commun205, 1755-1761. PubMed  Europe PubMed DOI
488. Sato,H., Takino,T., Okada,Y., Cao,J., Shinagawa,A., Yamamoto,E. and Seiki,M.
     A matrix metalloproteinase expressed on the surface of invasive tumour cells
     Nature370, 61-65. PubMed  Europe PubMed DOI
1993
489. Brown,P.D., Bloxidge,R.E., Anderson,E. and Howell,A.
     Expression of activated gelatinase in human invasive breast carcinoma
     Clin Exp Metastasis11, 183-189. PubMed  Europe PubMed
490. Brown,P.D., Bloxidge,R.E., Stuart,N.S., Gatter,K.C. and Carmichael,J.
     Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma
     J Natl Cancer Inst85, 574-578. PubMed  Europe PubMed
491. Crabbe,T., Ioannou,C. and Docherty,A.J.
     Human progelatinase A can be activated by autolysis at a rate that is concentration-dependent and enhanced by heparin bound to the C-terminal domain
     Eur J Biochem218, 431-438. PubMed  Europe PubMed DOI
492. Fridman,R., Bird,R.E., Hoyhtya,M., Oelkuct,M., Komarek,D., Liang,C.M., Berman,M.L., Liotta,L.A., Stetler-Stevenson,W.G. and Fuerst,T.R.
     Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme
     Biochem J289, 411-416. PubMed  Europe PubMed  E
493. Strongin,A.Y., Marmer,B.L., Grant,G.A. and Goldberg,G.I.
     Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP- 2
     J Biol Chem268, 14033-14039. PubMed  Europe PubMed
494. [YEAR:27-4-1993]Willenbrock,F., Crabbe,T., Slocombe,P.M., Sutton,C.W., Docherty,A.J., Cockett,M.I., O'Shea,M., Brocklehurst,K., Phillips,I.R. and Murphy,G.
     The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A
     Biochemistry32, 4330-4337. PubMed  Europe PubMed
1992
495. Kleiner,D.E., Jr., Unsworth,E.J., Krutzsch,H.C. and Stetler-Stevenson,W.G.
     Higher-order complex formation between the 72-kilodalton type IV collagenase and tissue inhibitor of metalloproteinases- 2
     Biochemistry31, 1665-1672. PubMed  Europe PubMed
496. Murphy,G., Willenbrock,F., Ward,R.V., Cockett,M.I., Eaton,D. and Docherty,A.J.
     The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases
     Biochem J283, 637-641. PubMed  Europe PubMed
497. Reponen,P., Sahlberg,C., Huhtala,P., Hurskainen,T., Thesleff,I. and Tryggvason,K.
     Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development
     J Biol Chem267, 7856-7862. PubMed  Europe PubMed
1991
498. Chen,J.M., Aimes,R.T., Ward,G.R., Youngleib,G.L. and Quigley,J.P.
     Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts
     J Biol Chem266, 5113-5121. PubMed  Europe PubMed
499. Howard,E.W. and Banda,M.J.
     Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site
     J Biol Chem266, 17972-17977. PubMed  Europe PubMed
500. Kolkenbrock,H., Orgel,D., Hecker-Kia,A., Noack,W. and Ulbrich,N.
     The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor
     Eur J Biochem198, 775-781. PubMed  Europe PubMed
501. Mast,A.E., Enghild,J.J., Nagase,H., Suzuki,K., Pizzo,S.V. and Salvesen,G.
     Kinetics and physiologic relevance of the inactivation of alpha1- proteinase inhibitor, alpha1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
     J Biol Chem266, 15810-15816. PubMed  Europe PubMed
502. Ward,R.V., Hembry,R.M., Reynolds,J.J. and Murphy,G.
     The purification of tissue inhibitor of metalloproteinases- 2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases- 2 and tissue inhibitor of metalloproteinases-1
     Biochem J278, 179-187. PubMed  Europe PubMed
503. Woessner,J.F., Jr.
     Matrix metalloproteinases and their inhibitors in connective tissue remodeling
     FASEB J5, 2145-2154. PubMed  Europe PubMed
1990
504. Okada,Y., Morodomi,T., Enghild,J.J., Suzuki,K., Yasui,A., Nakanishi,I., Salvesen,G. and Nagase,H.
     Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties
     Eur J Biochem194, 721-730. PubMed  Europe PubMed
1988
505. Collier,I.E., Wilhelm,S.M., Eisen,A.Z., Marmer,B.L., Grant,G.A., Seltzer,J.L., Kronberger,A., He,C.S., Bauer,E.A. and Goldberg,G.I.
     H-ras oncogene-transformed human bronchial epithelial cells (TBE- 1) secrete a single metalloprotease capable of degrading basement membrane collagen
     J Biol Chem263, 6579-6587. PubMed  Europe PubMed
1985
506. Murphy,G., McAlpine,C.G., Poll,C.T. and Reynolds,J.J.
     Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen
     Biochim Biophys Acta831, 49-58. PubMed  Europe PubMed