Literature for peptidase M10.003: matrix metallopeptidase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Luo,Q., Zheng,C., Huang,Y., Liang,L., Gong,Y., Zhang,J., Tang,Q., Zhang,K. and Liao,X. Polydopamine-stabilized CsPbBr(3) enables toxicity-reduced ECL detection of MMP-2 via CRISPR/Cas12a trans-cleavage Biosens Bioelectron (2026) 293, 118193-118193. PubMed Europe PubMed DOI

2025

Conde-Tella,S.O., Gerlach,R.F. and Tanus-Santos,J.E. Using Zymography to Assess Circulating Matrix Metalloproteinase (MMP)-2 and MMP-9 in Clinical Samples Methods Mol Biol (2025) 2918, 177-186. PubMed Europe PubMed DOI L
George,J. Zymography: A Simple and Powerful Tool for the Assessment of MMP-2 and MMP-9 in Pathological Conditions Methods Mol Biol (2025) 2918, 187-199. PubMed Europe PubMed DOI L
Lempicki,M.D., Garrigues,R.J., Hondros,A.D., Zeczycki,T.N., Garcia,B.L., Cavanagh,J., Harris,T.E. and Meher,A.K. Matrix metalloproteinase-2 as a novel regulator of glucose utilization by adipocytes Sci Rep (2025) 15, 24277-24277. PubMed Europe PubMed DOI PMC EPMC
Lin,X., Chen,Y., Zhong,B. and Yu,H. Cathepsin K and glycosaminoglycans differentially regulate matrix metalloproteinase activity in dentin under various pH conditions Int J Biol Macromol (2025) 327, 147486-147486. PubMed Europe PubMed DOI L
O'Neill,K.L., Zigmond,J.W. and Bergan,R. HSP90alpha and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC K L
Sarker,H., Panigrahi,R., Lopez-Campistrous,A., McMullen,T., Reyes,K., Anderson,E., Krishnan,V., Hernandez-Anzaldo,S., Zheng,X.L., Glover,J.N.M., Hardy,E. and Fernandez-Patron,C. Apolipoprotein-A1 transports and regulates MMP2 in the blood Nat Commun (2025) 16, 3752-3752. PubMed Europe PubMed DOI PMC EPMC
Sun,N., Wang,S., Liu,J., Zhang,P., Chang,Y., Li,H., Zhao,K., Liu,Y., Huang,M., Hu,Y., Lin,Z., Lu,Y., Jiang,G., Chen,W., Huang,C. and Jin,H. XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1 Cell Death Dis (2025) 16, 205-205. PubMed Europe PubMed DOI PMC EPMC
Takatsuka,R., Terashima,M., Ishimura,A., Suzuki,T. and Takino,T. Iron regulates MT1-MMP-mediated proMMP-2 activation and cancer cell invasion Biochem Biophys Res Commun (2025) 742, 151124-151124. PubMed Europe PubMed DOI
Veilleux,C., Roy,M.E. and Annabi,B. Assessing MMP-2/9 Proteolytic Activity and Activation Status by Zymography in Preclinical and Clinical Tissue Samples Methods Mol Biol (2025) 2918, 165-176. PubMed Europe PubMed DOI L
Zhu,Q., Sun,X., Du,Y., Zhang,X., Ren,X., Ma,H., Wu,D., Ju,H. and Wei,Q. Detection of Matrix Metalloproteinase 2 by a Polypeptide Cleavable Split-Type Sensor Based on Atomically Precise Bimetallic Nanocluster Au(3)Ag(5)(MSA)(3) Anal Chem (2025) 97, 14574-14583. PubMed Europe PubMed DOI A

2024

Alekhmimi,N., Ramadan,Q., Cialla-May,D., Popp,J., Al-Kattan,K., Alhoshani,A. and Zourob,M. In Vivo Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Imaging of MMP-2 in ALI/ARDS in LPS-Treated Mice ACS Omega (2024) 9, 3609-3615. PubMed Europe PubMed DOI PMC EPMC
Blascke de Mello,M.M., Neves,V.G.O., Parente,J.M., Pernomian,L., de Oliveira,I.S., Pedersoli,C.A., Awata,W.M.C., Tirapelli,C.R., Arantes,E.C., Tostes,R.C.A., Schulz,R. and Castro,M.M. Sarcoplasmic reticulum calcium ATPase (SERCA) proteolysis by matrix metalloproteinase-2 contributes to vascular dysfunction in early hypertension Eur J Pharmacol (2024) 983, 176981-176981. PubMed Europe PubMed DOI L
Capelli,L., Pedrini,F., Di Pede,A.C., Chamorro-Garcia,A., Bagheri,N., Fortunati,S., Giannetto,M., Mattarozzi,M., Corradini,R., Porchetta,A. and Bertucci,A. Synthetic Protein-to-DNA Input Exchange for Protease Activity Detection Using CRISPR-Cas12a Anal Chem (2024) PubMed Europe PubMed DOI
Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E. Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target Basic Clin Pharmacol Toxicol (2024) 134, 727-736. PubMed Europe PubMed DOI L
Chen,Y., Zhu,D., Zhong,H., Gan,Z., Zong,S., Wang,Z., Cui,Y. and Wang,Y. Ultrasensitive Detection of Matrix Metalloproteinase 2 Activity Using a Ratiometric Surface-Enhanced Raman Scattering Nanosensor with a Core-Satellite Structure ACS Appl Mater Interfaces (2024) 16, 4160-4168. PubMed Europe PubMed DOI
Cioates Negut,C., Ilie-Mihai,R.M. and Stefan-van Staden,R.I. Determination of Matrix Metalloproteinase 2 in Biological Samples Using a 3D Stochastic Microsensor Based on Graphene Oxide/AuNanoparticles/(Z)-N-(pyridin-4-yl-methyl) Octadec-9-enamide Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Gong,Y., Zhang,J., Xi,Y., Jian,D., Zhuo,C., Tang,Q., Zhang,K. and Liao,X. Highly sensitive detection of MMP-2 using an electrochemiluminescent biosensor enhanced by ladder-branch hybridization chain reaction Mikrochim Acta (2024) 191, 742-742. PubMed Europe PubMed DOI
Guo,J., Hu,M., Yang,M., Cao,H., Li,H., Zhu,J., Li,S. and Zhang,J. Inhibition mechanism of theaflavins on matrix metalloproteinase-2: inhibition kinetics, multispectral analysis, molecular docking and molecular dynamics simulation Food Funct (2024) PubMed Europe PubMed DOI
Kamarajan,P., Timm,J.C., Goetting-Minesky,M.P., Malone,E.T., Ganther,S., Radaic,A., Tafolla,C., Fenno,J.C. and Kapila,Y.L. Purification of Native Dentilisin Complex from Treponema denticola by Preparative Continuous Polyacrylamide Gel Electrophoresis and Functional Analysis by Gelatin Zymography Bio Protoc (2024) 14, e4970-e4970. PubMed Europe PubMed DOI PMC EPMC L
Morokuma,J., Garriz,A., Toribio,D., Pagni,S. and Zoukhri,D. Interleukin-1beta activates matrix metalloproteinase-2 to alter lacrimal gland myoepithelial cell structure and function Front Ophthalmol (Lausanne) (2024) 4, 1415002-1415002. PubMed Europe PubMed DOI PMC EPMC
Shi,Z., Yan,J., Zhao,M., Li,S., She,T. and Qian,X. Co-encapsulation of granzyme B and perforin in nanocapsules for tumour therapy: biomimicking immune cells J Control Release (2024) 369, 658-667. PubMed Europe PubMed DOI

2023

Baidya,S.K., Banerjee,S., Ghosh,B., Jha,T. and Adhikari,N. Assessing structural insights into in-house arylsulfonyl L-(+) glutamine MMP-2 inhibitors as promising anticancer agents through structure-based computational modelling approaches SAR QSAR Environ Res (2023) 34, 805-830. PubMed Europe PubMed DOI
Bassiouni,W., Valencia,R., Mahmud,Z., Seubert,J.M. and Schulz,R. Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia-reperfusion injury Basic Res Cardiol (2023) 118, 29-29. PubMed Europe PubMed DOI L
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N. Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14 Res Sq (2023) PubMed Europe PubMed DOI PMC EPMC
Hayun,H., Coban,M., Bhagat,A.K., Ozer,E., Alfonta,L., Caulfield,T.R., Radisky,E.S. and Papo,N. Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14 Sci Rep (2023) 13, 5186-5186. PubMed Europe PubMed DOI PMC EPMC
Ishaq,T., Loid,P., Ishaq,H.A., Seo,G.H., Makitie,O. and Naz,S. Clinical, radiographic and molecular characterization of two unrelated families with multicentric osteolysis, nodulosis, and arthropathy BMC Musculoskelet Disord (2023) 24, 735-735. PubMed Europe PubMed DOI PMC EPMC
Kowalczyk,A., Nisiewicz,M.K., Bamburowicz-Klimkowska,M., Kasprzak,A., Ruzycka-Ayoush,M., Koszytkowska-Stawinska,M. and Nowicka,A.M. Effective voltammetric tool for simultaneous detection of MMP-1, MMP-2, and MMP-9; important non-small cell lung cancer biomarkers Biosens Bioelectron (2023) 229, 115212-115212. PubMed Europe PubMed DOI
Li,P.H., Liao,C.H., Huang,W.C., Chang,W.S., Wu,H.C., Hsu,S.W., Chen,K.Y., Wang,Z.H., Hsia,T.C., Bau,D.T. and Tsai,C.W. Association of Matrix Metalloproteinase-2 Genotypes With Prostate Cancer Risk Anticancer Res (2023) 43, 343-349. PubMed Europe PubMed DOI
Luo,F.F., Wang,J., Zhang,Z.F., Lin,S.T., Huang,T.J., Liu,B.Q., Fan,M.L., Peng,L.X., Zheng,S.T., Yang,C.F. and Huang,B.J. SPI1-Mediated Upregulation of the CST1 Gene as an Independent Poor Prognostic Factor Accelerates Metastasis in Esophageal Squamous Cell Carcinoma (ESCC) by Interacting with MMP2 Front Biosci (Landmark Ed) (2023) 28, 212-212. PubMed Europe PubMed DOI
Reddy,R.A., Sai Varshini,M. and Kumar,R.S. Matrix Metalloproteinase-2 (MMP-2): As an Essential Factor in Cancer Progression Recent Pat Anticancer Drug Discov (2023) 20, 26-44. PubMed Europe PubMed DOI V
Ribeiro Vitorino,T., Ferraz do Prado,A., Bruno de Assis Cau,S. and Rizzi,E. MMP-2 and its implications on cardiac function and structure: Interplay with inflammation in hypertension Biochem Pharmacol (2023) 215, 115684-115684. PubMed Europe PubMed DOI V
Samah,N., Ugusman,A., Hamid,A.A., Sulaiman,N. and Aminuddin,A. Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease Mediators Inflamm (2023) 2023, 9715114-9715114. PubMed Europe PubMed DOI PMC EPMC V
Sangwan,P., Quasimi,H., Sharma,J.G., Habib,M.A. and Alam,M.I. Role of Oxidative Stress and Genetic Polymorphism of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in COPD Chronic Obstr Pulm Dis (2023) PubMed Europe PubMed DOI V
Takeuchi,T., Nomura,Y., Tamita,T., Nishikawa,R., Kakinuma,H., Kojima,N., Hitaka,K., Tamura,Y., Kamitani,M., Mima,M., Nozoe,A. and Hayashi,M. Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold J Med Chem (2023) 66, 822-836. PubMed Europe PubMed DOI I
Weekley,B.H. and Rice,J.C. The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes Epigenetics Chromatin (2023) 16, 16-16. PubMed Europe PubMed DOI PMC EPMC
Yao,T., Chen,J., Kong,L., Liu,Y., Yuan,R. and Chai,Y. Efficient Three-Dimensional DNA Nanomachine Guided by a Robust Tetrahedral DNA Nanoarray Structure for the Rapid and Ultrasensitive Electrochemical Detection of Matrix Metalloproteinase 2 Anal Chem (2023) 95, 13211-13219. PubMed Europe PubMed DOI
Zhang,Y.N., Liu,J.J., Zhang,W., Qin,H.Y., Wang,L.T., Chen,Y.Y., Yuan,L., Yang,F., Cao,R.Y. and Wang,X.J. Expression, purification and refolding of pro-MMP-2 from inclusion bodies of E. coli Protein Expr Purif (2023) 208-209, 106278-106278. PubMed Europe PubMed DOI L
Zhu,X., Song,Y., Wang,X., Zhou,Y., Chai,Y. and Yuan,R. Copper nanoclusters electrochemiluminescence with tunable near-infrared emission wavelength for ultrasensitive detection of matrix metalloproteinase-2 Biosens Bioelectron (2023) 238, 115580-115580. PubMed Europe PubMed DOI

2022

Maybee,D.V., Ink,N.L. and Ali,M.A.M. Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC V
Morales-Hernandez,F.V., Bautista-Bautista,G., Acuna-Gonzalez,R.J., Vazquez-Cardenas,P., Lopez-Canales,J.S., Lozano-Cuenca,J., Osorio-Caballero,M. and Flores-Herrera,H. Differential proMMP-2 and proMMP-9 secretion in human pre-implantation embryos at day 5 of development Acta Biochim Pol (2022) 69, 683-689. PubMed Europe PubMed DOI L
Sanyal,S., Amin,S.A., Banerjee,P., Gayen,S. and Jha,T. A review of MMP-2 structures and binding mode analysis of its inhibitors to strategize structure-based drug design Bioorg Med Chem (2022) 74, 117044-117044. PubMed Europe PubMed DOI

2021

Ali,M.A.M., Garcia-Vilas,J.A., Cromwell,C.R., Hubbard,B.P., Hendzel,M.J. and Schulz,R. Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones FEBS J (2021) PubMed Europe PubMed DOI
Anuar,N.N.M., Zulkafali,N.I.N. and Ugusman,A. Modulation of Matrix Metalloproteinases by Plant-Derived Products Curr Cancer Drug Targets (2021) 21, 91-106. PubMed Europe PubMed DOI V I
Bassiouni,W., Ali,M.A.M. and Schulz,R. Multifunctional intracellular matrix metalloproteinases: implications in disease FEBS J (2021) 288, 7162-7182. PubMed Europe PubMed DOI V
Bourgi,R., Daood,U., Bijle,M.N., Fawzy,A., Ghaleb,M. and Hardan,L. Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry Polymers (Basel) (2021) 13 PubMed Europe PubMed DOI PMC EPMC
Buttacavoli,M., Di Cara,G., Roz,E., Pucci-Minafra,I., Feo,S. and Cancemi,P. Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9 Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC L
Fang,Y., Li,Y., Li,Y., He,R., Zhang,Y., Zhang,X., Liu,Y. and Ju,H. In Situ Protease Secretion Visualization and Metastatic Lymph Nodes Imaging via a Cell Membrane-Anchored Upconversion Nanoprobe Anal Chem (2021) 93, 7258-7265. PubMed Europe PubMed DOI
Goossens,J.F., Goossens,L. and Bailly,C. Hinokiflavone and Related C-O-C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action Nat Prod Bioprospect (2021) PubMed Europe PubMed DOI PMC EPMC V I
Harwood,S.L., Nielsen,N.S., Diep,K., Jensen,K.T., Nielsen,P.K., Yamamoto,K. and Enghild,J.J. Development of selective protease inhibitors via engineering of the bait region of human alpha2-macroglobulin J Biol Chem (2021) 297, 100879-100879. PubMed Europe PubMed DOI PMC EPMC
Lenci,E., Angeli,A., Calugi,L., Innocenti,R., Carta,F., Supuran,C.T. and Trabocchi,A. Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II Eur J Med Chem (2021) 214, 113260-113260. PubMed Europe PubMed DOI
Li,X., Jin,L. and Tan,Y. Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis (Review) Mol Med Rep (2021) 23 PubMed Europe PubMed DOI
Liu,C.F., Xia,Y., To,J., Chan,N.Y., Hu,S., Liew,H.T., Balamkundu,S., Zhang,X., Lescar,J., Bhattacharjya,S. and Tam,J.P. Ngamma-Hydroxyasparagine: a Multifunctional Unnatural Amino Acid That is a Good P1 Substrate of Asparaginyl Peptide Ligases Angew Chem Int Ed Engl (2021) PubMed Europe PubMed DOI I
Liu,F., Chen,R., Song,W., Li,L., Lei,C. and Nie,Z. Modular Combination of Proteolysis-Responsive Transcription and Spherical Nucleic Acids for Smartphone-Based Colorimetric Detection of Protease Biomarkers Anal Chem (2021) 93, 3517-3525. PubMed Europe PubMed DOI
Nissi,R., Santala,M. and Talvensaari-Mattila,A. The serum levels of circulating matrix metalloproteinase MMP-9, MMP-2/TIMP-2 complex and TIMP-1 do not change significantly during normal pregnancy: a pilot study BMC Res Notes (2021) 14, 31-31. PubMed Europe PubMed DOI PMC EPMC
Rocchi,D., Blazquez-Barbadillo,C., Agamennone,M., Laghezza,A., Tortorella,P., Vicente-Zurdo,D., Rosales-Conrado,N., Moyano,P., Pino,J.D., Gonzalez,J.F. and Menendez,J.C. Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity Eur J Med Chem (2021) 210, 113061-113061. PubMed Europe PubMed DOI I
Tarki,S.E., Far,I.S., Aminimoghaddam,S., Fooladi,B., Sarhangi,N., Farahani,M.S., Klashami,Z.N., Hamidi,A.K. and Amoli,M.M. Investigating the association of matrix metalloproteinase-2 gene variants with endometriosis in an Iranian population Eur J Obstet Gynecol Reprod Biol (2021) 258, 353-357. PubMed Europe PubMed DOI
Tsegaye,S., Mehdi,M., Labisso,W.L. and Melka,D.S. Cysteine Cathepsins and Matrix Metalloproteases Among Breast Cancer Patients Breast Cancer (Dove Med Press) (2021) 13, 271-283. PubMed Europe PubMed DOI PMC EPMC L
Yuan,X., Bian,X., Wei,W., Bao,Q., Liu,P. and Jiang,W. miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2 Genet Mol Biol (2021) 44, e20200124-e20200124. PubMed Europe PubMed DOI PMC EPMC

2020

Amaral,A., Fernandes,C., Morazzo,S., Rebordao,M.R., Szostek-Mioduchowska,A., Lukasik,K., Gawronska-Kozak,B., Telo da Gama,L., Skarzynski,D.J. and Ferreira-Dias,G. The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare Front Vet Sci (2020) 7, 582211-582211. PubMed Europe PubMed DOI PMC EPMC
Azevedo Martins,J.M., Rabelo-Santos,S.H., do Amaral Westin,M.C. and Zeferino,L.C. Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis BMC Cancer (2020) 20, 660-660. PubMed Europe PubMed DOI PMC EPMC
Bai,X., Bai,G., Tang,L., Liu,L., Li,Y. and Jiang,W. Changes in MMP-2, MMP-9, inflammation, blood coagulation and intestinal mucosal permeability in patients with active ulcerative colitis Exp Ther Med (2020) 20, 269-274. PubMed Europe PubMed DOI PMC EPMC
Baidya,S.K., Amin,S.A. and Jha,T. Outline of gelatinase inhibitors as anti-cancer agents: A patent mini-review for 2010-present Eur J Med Chem (2020) , 113044-113044. PubMed Europe PubMed DOI V
Bakshi,J., Goyal,A.K., Singh,V., Sannigrahi,M. and Khullar,M. Stage-specific expression analysis ofMMP-2 & MMP-9 in laryngeal carcinoma J Cancer Res Ther (2020) 16, 517-520. PubMed Europe PubMed DOI
Barbe,A.M., Berbets,A.M., Davydenko,I.S., Koval,H.D., Yuzko,V.O. and Yuzko,O.M. Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis J Med Life (2020) 13, 314-320. PubMed Europe PubMed DOI PMC EPMC
Becker,D.P., Lutz,M.R., Flieger,S., Colorina,A., Wozny,J. and Hosmane,N.S. Carborane-containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron Capture Therapy (BNCT) ChemMedChem (2020) PubMed Europe PubMed DOI I
Bollmann,M., Pinno,K., Ehnold,L.I., Martens,N., Martson,A., Pap,T., Starke,C., Lohmann,C.H. and Bertrand,J. MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity Osteoarthritis Cartilage (2020) PubMed Europe PubMed DOI K
Carrilho,M.R., Scaffa,P., Oliveira,V., Tjaderhane,L., Tersariol,I.L., Pashley,D.H., Tay,F. and Nascimento,F.D. Insights into cathepsin-B activity in mature dentin matrix Arch Oral Biol (2020) 117, 104830-104830. PubMed Europe PubMed DOI
Cheeran,V. and Munuswamy-Ramanujam,G. Sesquiterpene lactone Zaluzanin D alters MMP-9 promoter methylation in differentiated THP-1 monocytic cells and down regulates inflammatory cytokines IL-1beta and TNF-alpha Int Immunopharmacol (2020) 87, 106803-106803. PubMed Europe PubMed DOI
Chen,Z., Zhang,F., Zhang,S. and Ma,L. The down-regulation of SNCG inhibits the proliferation and invasiveness of human bladder cancer cell line 5637 and suppresses the expression of MMP-2/9 Int J Clin Exp Pathol (2020) 13, 1873-1879. PubMed Europe PubMed PMC EPMC K
de Figueiredo,F.A.T., Azevedo,J.P., Lara,M.G., Meschiari,C.A., Issa,J.P.M., Gerlach,R.F. and Lamano,T.C.L. Recombinant human MMP-2 associated with monoolein improves bone repair Bratisl Lek Listy (2020) 121, 571-579. PubMed Europe PubMed DOI
Dofara,S.G., Chang,S.L. and Diorio,C. Gene Polymorphisms and Circulating Levels of MMP-2 and MMP-9: A Review of Their Role in Breast Cancer Risk Anticancer Res (2020) 40, 3619-3631. PubMed Europe PubMed DOI
Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y. USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer Onco Targets Ther (2020) 13, 8495-8510. PubMed Europe PubMed DOI PMC EPMC L
Drishya,G., Nambiar,J., Shaji,S.K., Vanuopadath,M., Achuthan,A., Kumar,A., Alias,A., Sherif,A., Joseph,C., Divya,P., Kumar,D.S., Bose,C., Nair,S.V., Sudarslal,S., Kumar,G.B., Lakshmi,S. and Nair,B.G. RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata J Biosci (2020) 45 PubMed Europe PubMed
El-Hussieny,M., Mohammed,E.M., Zenhom,N.M., Refaie,M.M., Okasha,A.M. and Tawab,M.A.E. Possible Role of TGF-beta1, MMP-2, E-CAD, beta-Catenin and Antioxidants in Pathogenesis of Placenta Accreta Fetal Pediatr Pathol (2020) , 1-11. PubMed Europe PubMed DOI
Gou,X., Xue,Y., Zheng,H., Yang,G., Chen,S., Chen,Z. and Yuan,G. Gelatinases Cleave Dentin Sialoprotein Intracellularly Front Physiol (2020) 11, 686-686. PubMed Europe PubMed DOI PMC EPMC L
Guo,W., Zhang,B., Sun,C., Duan,H.Q., Liu,W.X., Mu,K., Zhao,L., Li,H.R., Dong,Z.Y. and Cui,Q. Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR1855p and matrix metalloproteinase 2 Int J Mol Med (2020) 46, 621-632. PubMed Europe PubMed DOI PMC EPMC
Hazzaa,H.H., El Shiekh,M.A.M., Abdelgawad,N., Gouda,O.M. and Kamal,N.M. Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study J Oral Biol Craniofac Res (2020) 10, 747-752. PubMed Europe PubMed DOI PMC EPMC
Huang,C.C., Wang,P.H., Lu,Y.T., Yang,J.S., Yang,S.F., Ho,Y.T., Lin,C.W. and Hsin,C.H. Morusin Suppresses Cancer Cell Invasion and MMP-2 Expression through ERK Signaling in Human Nasopharyngeal Carcinoma Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC
Ji,J.J., Qian,L.L., Zhu,Y., Wu,Y.P., Guo,J.Q., Ma,G.S. and Yao,Y.Y. Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway Cell Signal (2020) 75, 109745-109745. PubMed Europe PubMed DOI
Kaczorowska,A., Miekus,N., Stefanowicz,J. and Adamkiewicz-Drozynska,E. Selected Matrix Metalloproteinases (MMP-2, MMP-7) and Their Inhibitor (TIMP-2) in Adult and Pediatric Cancer Diagnostics (Basel) (2020) 10 PubMed Europe PubMed DOI V
Ke,J.Y., Yang,J., Li,J., Xu,Z., Li,M.Q. and Zhu,Z.L. Baicalein inhibits FURIN-MT1-MMP-mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1 Am J Reprod Immunol (2020) , e13344-e13344. PubMed Europe PubMed DOI
Kensara,A., Hefni,E., Williams,M.A., Saito,H., Mongodin,E. and Masri,R. Microbiological Profile and Human Immune Response Associated with Peri-Implantitis: A Systematic Review J Prosthodont (2020) PubMed Europe PubMed DOI V
Kiani,A., Kamankesh,M., Vaisi-Raygani,A., Moradi,M.R., Tanhapour,M., Rahimi,Z., Elahi-Rad,S., Bahrehmand,F., Aliyari,M., Aghaz,F., Mozafari,H., Rezvani,N., Haghnazari,L. and Pourmotabbed,T. Activities and polymorphisms of MMP-2 and MMP-9, smoking, diabetes and risk of prostate cancer Mol Biol Rep (2020) PubMed Europe PubMed DOI
Kim,J. and Kim,M.M. Effect of Lapachol on the Inhibition of Matrix Metalloproteinase Related to the Invasion of Human Fibrosarcoma Cells Curr Mol Pharmacol (2020) PubMed Europe PubMed DOI
Lee,H., Kim,S.J., Shin,H. and Kim,Y.P. Collagen-immobilized extracellular FRET reporter for visualizing protease activity secreted by living cells ACS Sens (2020) 5, 655-664. PubMed Europe PubMed DOI L
Lenci,E., Contini,A. and Trabocchi,A. Discovery of a d-pro-lys peptidomimetic inhibitor of MMP9: Addressing the gelatinase selectivity beyond S1' subsite Bioorg Med Chem Lett (2020) 30, 127467-127467. PubMed Europe PubMed DOI
Li,H., Ma,R.Q., Cheng,H.Y., Ye,X., Zhu,H.L. and Chang,X.H. Fibrinogen alpha chain (FGA) promotes the migration and invasion of human endometrial stromal cells in endometriosis through FAK/AKT/MMP-2 pathwaydagger Biol Reprod (2020) PubMed Europe PubMed DOI
Luo,W., Yu,Y., Wang,H., Liu,K., Wang,Y., Huang,M., Xuan,C., Li,Y. and Qi,J. Up-regulation of MMP-2 by histone H3K9 beta-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat Acta Diabetol (2020) PubMed Europe PubMed DOI
Malik,A., Pal,R. and Gupta,S.K. EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression Sci Rep (2020) 10, 12274-12274. PubMed Europe PubMed DOI PMC EPMC
Miao,R., Dong,X., Gong,J., Wang,Y., Guo,X., Li,Y., Liu,M., Wan,J., Li,J., Yang,S., Wang,W., Kuang,T., Zhong,J., Zhai,Z. and Yang,Y. hsa-miR-106b-5p participates in the development of chronic thromboembolic pulmonary hypertension via targeting matrix metalloproteinase 2 Pulm Circ (2020) 10, 2045894020928300-2045894020928300. PubMed Europe PubMed DOI PMC EPMC
Morales-Vasquez,F., Castillo-Sanchez,R., Gomora,M.J., Almaraz,M.A., Pedernera,E., Perez-Montiel,D., Rendon,E., Lopez-Basave,H.N., Roman-Basaure,E., Cuevas-Covarrubias,S., Maldonado-Cubas,J., Villa,A. and Mendez,C. Expression of metalloproteinases MMP-2 and MMP-9 is associated to the presence of androgen receptor in epithelial ovarian tumors J Ovarian Res (2020) 13, 86-86. PubMed Europe PubMed DOI PMC EPMC
Nie,S., Lou,L., Wang,J., Cui,J., Wu,W., Zhang,Q., Liu,Y., Su,L., Chang,Y., Guo,W., Shen,H., Xing,L. and Li,Y. Expression, association with clinicopathological features and prognostic potential of CEP55, p-Akt, FoxM1 and MMP-2 in astrocytoma Oncol Lett (2020) 20, 1685-1694. PubMed Europe PubMed DOI PMC EPMC
Nogueira,M.E., Sousa Neto,I.V., Motta-Santos,D., Cantuaria,A.P.C., Lima,S.M.F., Rezende,T.M.B., Santana,H.A.P., Petriz,B.A., Marqueti,R.C. and Almeida,J.A. High-protein diet associated with resistance training reduces cardiac TNF-alpha levels and up-regulates MMP-2 activity in rats Arch Physiol Biochem (2020) , 1-7. PubMed Europe PubMed DOI
Olsman,M., Sereti,V., Andreassen,K., Snipstad,S., van Wamel,A., Eliasen,R., Berg,S., Urquhart,A.J., Andresen,T.L. and Davies,C.L. Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes J Control Release (2020) 325, 121-134. PubMed Europe PubMed DOI
Omar,A.M., Bajorath,J., Ihmaid,S., Mohamed,H.M., El-Agrody,A.M., Mora,A., El-Araby,M.E. and Ahmed,H.E.A. Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects Bioorg Chem (2020) 101, 103992-103992. PubMed Europe PubMed DOI I
Pan,S., Zhang,Z., Li,C. and Yang,D. Interleukin-25 regulates matrix metalloproteinase-2 and -9 expression in periodontal fibroblast cells through ERK and P38MAPK pathways Cell Biol Int (2020) PubMed Europe PubMed DOI
Qiao,Y., Zhan,C., Wang,C., Shi,X., Yang,J., He,X., Ji,E., Yu,Z., Yan,C. and Wu,H. MMP-2 sensitive poly(malic acid) micelles stabilized by pi-pi stacking enable high drug loading capacity J Mater Chem B (2020) 8, 8527-8535. PubMed Europe PubMed DOI
Singh,M.P., Sharma,C. and Kang,S.C. Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling Int Immunopharmacol (2020) 90, 107234-107234. PubMed Europe PubMed DOI
Song,X., Yang,W., Wu,C., Han,Y. and Lu,Y. USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling Oncol Lett (2020) 20, 2897-2905. PubMed Europe PubMed DOI PMC EPMC K
Tjahajawati,S., Zulhazmi,A., Cahyanto,A., Mariam,M.S., Djustiana,N., Aripin,D., Usri,K. and Widyaputra,S.S. Matrix levels of metalloproteinase-2 (MMP-2) and toxicity evaluation of carbonate apatite-based endodontic sealer in rat subcutaneous implantation Heliyon (2020) 6, e04330-e04330. PubMed Europe PubMed DOI PMC EPMC
Vira,H.J., Pradhan,V.D., Umare,V.D., Chaudhary,A.K., Rajadhyksha,A.G., Nadkar,M.Y., Ghosh,K. and Nadkarni,A.H. Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients Neth J Med (2020) 78, 261-268. PubMed Europe PubMed
Voitiv,Y., Usenko,O., Dosenko,V., Dyadyk,O. and Dzhemiliev,A. ANALYSIS OF POLYMORPHISM OF MATRIX METALLOPROTEINASE-2 (C-1306 Georgian Med News (2020) , 7-12. PubMed Europe PubMed
Wang,H., Huang,L., Wu,L., Lan,J., Feng,X., Li,P. and Peng,Y. The MMP-2/TIMP-2 system in Alzheimer disease CNS Neurol Disord Drug Targets (2020) 19, 402-416. PubMed Europe PubMed DOI V
Wu,W.C., Lee,W.J., Lee,T.H., Chen,S.C. and Chen,C.Y. Do different bariatric surgical procedures influence plasma levels of matrix metalloproteinase-2, -7, and -9 among patients with type 2 diabetes mellitus? World J Diabetes (2020) 11, 252-260. PubMed Europe PubMed DOI PMC EPMC
Yang,B., Zhang,D., Qian,J. and Cheng,Y. Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system Mol Cell Biochem (2020) 474, 199-208. PubMed Europe PubMed DOI
Yuan,J., Zhang,G., Li,X., Ma,Q., Cheng,W., Wang,W., Zhang,B., Hu,T. and Song,G. Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC K
Yue,Y., Hsiao,Y.W. and Zhou,J.B. Association between MMP/TIMP Levels in the Aqueous Humor and Plasma with Axial Lengths in Myopia Patients Biomed Res Int (2020) 2020, 2961742-2961742. PubMed Europe PubMed DOI PMC EPMC
Zhang,L., Cui,Y., Yang,Y., Wei,J., Liu,W., Cai,L., Wang,L., Zhang,D., Xie,J. and Cheng,L. The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells Arch Oral Biol (2020) 122, 104991-104991. PubMed Europe PubMed DOI L
Zhang,Y., Liu,H., Chen,Z., Yu,M., Li,J., Dong,H., Li,N., Ding,X., Ge,Y., Liu,C., Ma,T. and Gui,B. TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice Neurochem Int (2020) 140, 104818-104818. PubMed Europe PubMed DOI
Zhao,F., Wu,H., Reinach,P.S., Wu,Y., Zhai,Y., Lei,Y., Ma,L., Su,Y., Chen,Y., Li,F., Liu,X., Srinivasalu,N., Qu,J. and Zhou,X. Up-Regulation of Matrix Metalloproteinase-2 by Scleral Monocyte-Derived Macrophages Contributes to Myopia Development Am J Pathol (2020) 190, 1888-1908. PubMed Europe PubMed DOI
Zhou,Y. and He,C. Functional expression and purification of the untagged C-terminal domain of MMP-2 from Escherichia coli inclusion bodies Protein Expr Purif (2020) 176, 105726-105726. PubMed Europe PubMed DOI

2019

Abu Bakar,A.R., Ripen,A.M., Merican,A.F. and Mohamad,S.B. Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 Nat Prod Res (2019) 33, 1765-1768. PubMed Europe PubMed DOI I
Bai,P., Lyu,L., Yu,T., Zuo,C., Fu,J., He,Y., Wan,Q., Wan,N., Jia,D. and Lyu,A. Macrophage-derived legumain promotes pulmonary hypertension by activating the MMP (matrix metalloproteinase)-2/TGF (transforming growth factor)-beta1 signaling Arterioscler Thromb Vasc Biol (2019) 39, e130-e130. PubMed Europe PubMed DOI
Bertran,A., Khomiak,D., Konopka,A., Rejmak,E., Bulska,E., Seco,J., Kaczmarek,L., Tarrago,T. and Prades,R. Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors Bioorg Chem (2019) , 103365-103365. PubMed Europe PubMed DOI I
Chan,B.Y.H., Roczkowsky,A., Cho,W.J., Poirier,M., Lee,T.Y.T., Mahmud,Z. and Schulz,R. Junctophilin-2 is a target of matrix metalloproteinase-2 in myocardial ischemia-reperfusion injury Basic Res Cardiol (2019) 114, 42-42. PubMed Europe PubMed DOI
Cook,R., Sarker,H. and Fernandez-Patron,C. Pathologies of matrix metalloproteinase-2 underactivity: a perspective on a neglected condition Can J Physiol Pharmacol (2019) 97, 486-492. PubMed Europe PubMed DOI K
Fallata,A.M., Wyatt,R.A., Levesque,J.M., Dufour,A., Overall,C.M. and Crawford,B.D. Intracellular localization in zebrafish muscle and conserved sequence features suggest roles for gelatinase A moonlighting in sarcomere maintenance Biomedicines (2019) 7 PubMed Europe PubMed DOI
Hannocks,M.J., Zhang,X., Gerwien,H., Chashchina,A., Burmeister,M., Korpos,E., Song,J. and Sorokin,L. The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes Matrix Biol (2019) 75-76, 102-113. PubMed Europe PubMed DOI
Kanda,H., Shimamura,R., Koizumi-Kitajima,M. and Okano,H. Degradation of extracellular matrix by matrix metalloproteinase 2 is essential for the establishment of the blood-brain barrier in Drosophila iScience (2019) 16, 218-229. PubMed Europe PubMed DOI PMC EPMC
Laghezza,A., Luisi,G., Caradonna,A., Di Pizio,A., Piemontese,L., Loiodice,F., Agamennone,M. and Tortorella,P. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors Bioorg Med Chem (2019) , 115257-115257. PubMed Europe PubMed DOI I
Lian,Y.Y., He,H.H., Zhang,C.Z., Li,X.C. and Chen,Y.H. Functional characterization of a matrix metalloproteinase 2 gene in Litopenaeus vannamei Fish Shellfish Immunol (2019) 84, 404-413. PubMed Europe PubMed DOI
Lyu,Y., Xiao,Q., Yin,L., Yang,L. and He,W. Potent delivery of an MMP inhibitor to the tumor microenvironment with thermosensitive liposomes for the suppression of metastasis and angiogenesis Signal Transduct Target Ther (2019) 4, 26-26. PubMed Europe PubMed DOI I
Marturano,A., Hendrickx,M.L.V., Falcinelli,E., Sebastiano,M., Guglielmini,G., Hassanzadeh-Ghassabeh,G., Muyldermans,S., Declerck,P.J. and Gresele,P. Development of anti-matrix metalloproteinase-2 (MMP-2) nanobodies as potential therapeutic and diagnostic tools Nanomedicine (2019) 24, 102103-102103. PubMed Europe PubMed DOI
Sarker,H., Hardy,E., Haimour,A., Maksymowych,W.P., Botto,L.D. and Fernandez-Patron,C. Identification of fibrinogen as a natural inhibitor of MMP-2 Sci Rep (2019) 9, 4340-4340. PubMed Europe PubMed DOI
Wang,H., Ma,Z. and Han,H. A novel impedance enhancer for amperometric biosensor based ultrasensitive detection of matrix metalloproteinase-2 Bioelectrochemistry (2019) 130, 107324-107324. PubMed Europe PubMed DOI A
Yin,L., Sun,H., Zhang,H., He,L., Qiu,L., Lin,J., Xia,H., Zhang,Y., Ji,S., Shi,H. and Gao,M. Quantitatively visualizing tumor-related protease activity in vivo using a ratiometric photoacoustic probe J Am Chem Soc (2019) 141, 3265-3273. PubMed Europe PubMed DOI L
Yin,L., Sun,H., Zhao,M., Wang,A., Qiu,S., Gao,Y., Ding,J., Ji,S.J., Shi,H. and Gao,M. Rational design and synthesis of a metalloproteinase-activatable probe for dual-modality imaging of metastatic lymph nodes in vivo J Org Chem (2019) 84, 6126-6133. PubMed Europe PubMed DOI L

2018

Bencsik,P., Kupai,K., Gorbe,A., Kenyeres,E., Varga,Z.V., Paloczi,J., Gaspar,R., Kovacs,L., Weber,L., Takacs,F., Hajdu,I., Fabo,G., Cseh,S., Barna,L., Csont,T., Csonka,C., Dorman,G. and Ferdinandy,P. Development of matrix metalloproteinase-2 inhibitors for cardioprotection Front Pharmacol (2018) 9, 296-296. PubMed Europe PubMed DOI PMC EPMC I
Beutel,B., Song,J., Konken,C.P., Korpos,E., Schinor,B., Gerwien,H., Vidyadharan,R., Burmeister,M., Li,L., Haufe,G. and Sorokin,L. New in vivo compatible matrix metalloproteinase (MMP)-2 and MMP-9 inhibitors Bioconjug Chem (2018) 29, 3715-3725. PubMed Europe PubMed DOI I
Cao,S., Li,Z., Zhao,J., Chen,M. and Ma,N. Rational engineering a multichannel upconversion sensor for multiplex detection of matrix metalloproteinase activities ACS Sens (2018) 3, 1522-1530. PubMed Europe PubMed DOI L
Cowell,S., Carroll,L., Lavdas,I., Aboagye,E.O. and Vilar,R. Towards an MMP-2-activated molecular agent for cancer imaging Dalton Trans (2018) 47, 1530-1534. PubMed Europe PubMed DOI L
Gioia,M., Fasciglione,G.F., Sbardella,D., Sciandra,F., Casella,M., Camerini,S., Crescenzi,M., Gori,A., Tarantino,U., Cozza,P., Brancaccio,A., Coletta,M. and Bozzi,M. The enzymatic processing of alpha-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site PLoS ONE (2018) 13, e0192651-e0192651. PubMed Europe PubMed DOI
Jha,T., Adhikari,N., Saha,A. and Amin,S.A. Multiple molecular modelling studies on some derivatives and analogues of glutamic acid as matrix metalloproteinase-2 inhibitors SAR QSAR Environ Res (2018) 29, 43-68. PubMed Europe PubMed DOI I
Kim,I.Y., Kim,S.S., Lee,H.W., Bae,S.S., Ha,H.K., Jung,E.S., Lee,M.Y., Han,M., Rhee,H., Seong,E.Y., Lee,D.W., Lee,S.B., Lovett,D.H. and Song,S.H. The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus BMC Nephrol (2018) 19, 248-248. PubMed Europe PubMed DOI PMC EPMC
Kuwabara,Y., Kobayashi,T., D'Alessandro-Gabazza,C.N., Toda,M., Yasuma,T., Nishihama,K., Takeshita,A., Fujimoto,H., Nagao,M., Fujisawa,T. and Gabazza,E.C. Role of matrix metalloproteinase-2 in eosinophil-mediated airway remodeling Front Immunol (2018) 9, 2163-2163. PubMed Europe PubMed DOI PMC EPMC
Li,X. Gelatinase inhibitors: a patent review (2011-2017) Expert Opin Ther Pat (2018) 28, 31-46. PubMed Europe PubMed DOI V I
Liu,C., Li,S., Gu,Y., Xiong,H., Wong,W.T. and Sun,L. Multispectral photoacoustic imaging of tumor protease activity with a gold nanocage-based activatable probe Mol Imaging Biol (2018) 20, 919-929. PubMed Europe PubMed DOI A L
Liu,J.W. and Chen,D.Q. Correlations of MMP-2 and MMP-9 gene polymorphisms with the risk of hepatopulmonary syndrome in cirrhotic patients: a case-control study Kaohsiung J Med Sci (2018) 34, 634-642. PubMed Europe PubMed DOI M
Mangiatordi,G.F., Guzzo,T., Rossano,E.C., Trisciuzzi,D., Alberga,D., Fasciglione,G., Coletta,M., Topai,A. and Nicolotti,O. Design, synthesis, and biological evaluation of tetrahydro-beta-carboline derivatives as selective sub-nanomolar gelatinase inhibitors ChemMedChem (2018) 13, 1343-1352. PubMed Europe PubMed DOI I
Nadolski,G.J., Hunt,S.J., Weber,C.N., Mohammed,M., Pulido,S., Noji,M., Chisholm,A. and Gade,T.P.F. Near-infrared fluorescence imaging of matrix metalloproteinase 2 activity as a biomarker of vascular remodeling in hemodialysis access J Vasc Interv Radiol (2018) 29, 1268-1275. PubMed Europe PubMed DOI L
Shamsara,J. Identification of non-zinc binding inhibitors of MMP-2 through virtual screening and subsequent rescoring Drug Res (Stuttg) (2018) 68, 529-535. PubMed Europe PubMed DOI I
Tauro,M. and Lynch,C.C. Cutting to the chase: how matrix metalloproteinase-2 activity controls breast-cancer-to-bone metastasis Cancers (Basel) (2018) 10 PubMed Europe PubMed DOI
Zhang,H., Wang,X., Mao,J., Huang,Y., Xu,W., Duan,Y. and Zhang,J. Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity Bioorg Med Chem (2018) 26, 4363-4374. PubMed Europe PubMed DOI I

2017

Adhikari,N., Mukherjee,A., Saha,A. and Jha,T. Arylsulfonamides and selectivity of matrix metalloproteinase-2: an overview Eur J Med Chem (2017) 129, 72-109. PubMed Europe PubMed DOI V I
Almalki,S.G., Llamas Valle,Y. and Agrawal,D.K. MMP-2 and MMP-14 silencing inhibits VEGFR2 cleavage and induces the differentiation of porcine adipose-derived mesenchymal stem cells to endothelial cells Stem Cells Transl Med (2017) 6, 1385-1398. PubMed Europe PubMed DOI K
Ceron,C.S., Baligand,C., Joshi,S., Wanga,S., Cowley,P.M., Walker,J.P., Song,S.H., Mahimkar,R., Baker,A.J., Raffai,R.L., Wang,Z.J. and Lovett,D.H. An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury Am J Physiol Renal Physiol (2017) 312, F1166-F1183. PubMed Europe PubMed DOI
Cheng,H., Li,S.Y., Zheng,H.R., Li,C.X., Xie,B.R., Chen,K.W., Li,B. and Zhang,X.Z. Multi-Forster resonance energy transfer-based fluorescent probe for spatiotemporal matrix metalloproteinase-2 and caspase-3 imaging Anal Chem (2017) 89, 4349-4354. PubMed Europe PubMed DOI L
Chowdhury,A., Nandy,S.K., Sarkar,J., Chakraborti,T. and Chakraborti,S. Inhibition of pro-/active MMP-2 by green tea catechins and prediction of their interaction by molecular docking studies Mol Cell Biochem (2017) 427, 111-122. PubMed Europe PubMed DOI I
Kim,S.S., Shin,N., Bae,S.S., Lee,M.Y., Rhee,H., Kim,I.Y., Seong,E.Y., Lee,D.W., Lee,S.B., Kwak,I.S., Lovett,D.H. and Song,S.H. Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy PLoS ONE (2017) 12, e0171625-e0171625. PubMed Europe PubMed DOI
Mukherjee,A., Adhikari,N. and Jha,T. A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line Eur J Med Chem (2017) 141, 37-50. PubMed Europe PubMed DOI I
Pillai,S.S., Yukawa,H., Onoshima,D., Biju,V. and Baba,Y. Forster resonance energy transfer mediated photoluminescence quenching in stoichiometrically assembled CdSe/ZnS quantum dot-peptide labeled black hole quencher conjugates for matrix metalloproteinase-2 sensing Anal Sci (2017) 33, 137-142. PubMed Europe PubMed DOI L
Tauro,M., Shay,G., Sansil,S.S., Laghezza,A., Tortorella,P., Neuger,A.M., Soliman,H. and Lynch,C.C. Bone-seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth Mol Cancer Ther (2017) 16, 494-505. PubMed Europe PubMed DOI I
Zhu,X., Lin,H., Wang,L., Tang,X., Ma,L., Chen,Z. and Gao,J. Activatable T1 relaxivity recovery nanoconjugates for kinetic and sensitive analysis of matrix metalloprotease 2 ACS Appl Mater Interfaces (2017) 9, 21688-21696. PubMed Europe PubMed DOI L

2016

Adhikari,N., Halder,A.K., Mallick,S., Saha,A., Saha,K.D. and Jha,T. Robust design of some selective matrix metalloproteinase-2 inhibitors over matrix metalloproteinase-9 through in silico/fragment-based lead identification and de novo lead modification: Syntheses and biological assays Bioorg Med Chem (2016) 24, 4291-4309. PubMed Europe PubMed DOI I
Ammazzalorso,A., De Filippis,B., Campestre,C., Laghezza,A., Marrone,A., Amoroso,R., Tortorella,P. and Agamennone,M. Seeking for non-zinc-binding MMP-2 inhibitors: synthesis, biological evaluation and molecular modelling studies Int J Mol Sci (2016) 17 PubMed Europe PubMed DOI PMC EPMC I
Bae,M.J., Karadeniz,F., Lee,S.G., Seo,Y. and Kong,C.S. Inhibition of MMP-2 and MMP-9 activities by Limonium tetragonum extract Prev Nutr Food Sci (2016) 21, 38-43. PubMed Europe PubMed DOI PMC EPMC I
Beber,A.R., Polina,E.R., Biolo,A., Santos,B.L., Gomes,D.C., La Porta,V.L., Olsen,V., Clausell,N., Rohde,L.E. and Santos,K.G. Matrix metalloproteinase-2 polymorphisms in chronic heart failure: relationship with susceptibility and long-term survival PLoS ONE (2016) 11, e0161666-e0161666. PubMed Europe PubMed DOI M
Bourguet,E., Brazhnik,K., Sukhanova,A., Moroy,G., Brassart-Pasco,S., Martin,A.P., Villena,I., Bellon,G., Sapi,J. and Nabiev,I. Design, synthesis, and use of MMP-2 inhibitor-conjugated quantum dots in functional biochemical assays Bioconjug Chem (2016) 27, 1067-1081. PubMed Europe PubMed DOI L I
Dang,Q., Gao,H., Li,Z., Qi,H., Gao,Q. and Zhang,C. Simple and sensitive electrogenerated chemiluminescence peptide-based biosensor for detection of matrix metalloproteinase 2 released from living cells Anal Bioanal Chem (2016) 408, 7067-7075. PubMed Europe PubMed DOI A L
Gao,M., Zhang,H., Trivedi,A., Mahasenan,K.V., Schroeder,V.A., Wolter,W.R., Suckow,M.A., Mobashery,S., Noble-Haeusslein,L.J. and Chang,M. Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury ACS Chem Neurosci (2016) 7, 1482-1487. PubMed Europe PubMed DOI I
Gerwien,H., Hermann,S., Zhang,X., Korpos,E., Song,J., Kopka,K., Faust,A., Wenning,C., Gross,C.C., Honold,L., Melzer,N., Opdenakker,G., Wiendl,H., Schafers,M. and Sorokin,L. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier Sci Transl Med (2016) 8, 364ra152-364ra. PubMed Europe PubMed DOI L
He,W., Jiang,J., Yu,Z.Q. and Zhou,J.H. Novel 5-hydroxy, 5-substituted benzenesulfonamide pyrimidine-2,4,6-triones attenuate lipopolysaccharide-induced acute lung injury via inhibition of the gelatinases, MMP-2 and MMP-9 Drug Dev Res (2016) 77, 251-257. PubMed Europe PubMed DOI I
Jha,S., Kanaujia,S.P. and Limaye,A.M. Direct inhibition of matrix metalloproteinase-2 (MMP-2) by (-)-epigallocatechin-3-gallate: a possible role for the fibronectin type II repeats Gene (2016) 593, 126-130. PubMed Europe PubMed DOI I
Joshi,S.K., Lee,L., Lovett,D.H., Kang,H., Kim,H.T., Delgado,C. and Liu,X. Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury J Orthop Res (2016) 34, 502-509. PubMed Europe PubMed DOI
Jun-Zhang, Wang,X.-J., Dong,Z.-K., Wang,S.-Q., Xu,W.-R., Fu,J.-W., Cheng,X.-C. and Wang,R.-L. CoMFA/CoMSIA and molecular docking studies of novel matrix metalloproteinase- 2 inhibitors based on l-tyrosine scaffold Lett Drug Des Discov (2016) 13, 376-386. I
Khrenova,M.G., Solovyev,I.D., Azev,V.N., Lapshin,G.D. and Savitsky,A.P. Oxoethylene derivative of the natural substrate as an inhibitor of matrix metalloproteinase MMP-2 Mendeleev Commun (2016) 26, 207-208. DOI I
Lemmens,K., Hove,I.V. and Moons,L. Complementary research in mammals and fish indicates MMP-2 as a pleiotropic contributor to optic nerve regeneration Neural Regen Res (2016) 11, 740-742. PubMed Europe PubMed DOI PMC EPMC
Nambiar,J., Bose,C., Venugopal,M., Banerji,A., Patel,T.B., Kumar,G.B. and Nair,B.G. Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK Exp Cell Res (2016) 349, 139-151. PubMed Europe PubMed DOI I
Vasilevskaya,T., Khrenova,M.G., Nemukhin,A.V. and Thiel,W. Methodological aspects of QM/MM calculations: a case study on matrix metalloproteinase-2 J Comput Chem (2016) 37, 1801-1809. PubMed Europe PubMed DOI S
Wang,D., Yuan,Y., Zheng,Y., Chai,Y. and Yuan,R. An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification Chem Commun (Camb) (2016) 52, 5943-5945. PubMed Europe PubMed DOI A
Xi,G., Wang,X. and Chen,T. A reduced graphene oxide-based fluorescence resonance energy transfer sensor for highly sensitive detection of matrix metalloproteinase 2 Int J Nanomedicine (2016) 11, 1537-1547. PubMed Europe PubMed DOI PMC EPMC A
Yang,J.K., Kwak,S.Y., Jeon,S.J., Lee,E., Ju,J.M., Kim,H.I., Lee,Y.S. and Kim,J.H. Proteolytic disassembly of peptide-mediated graphene oxide assemblies for turn-on fluorescence sensing of proteases Nanoscale (2016) 8, 12272-12281. PubMed Europe PubMed DOI A
Zhang,L., Ren,R. and Mu,S. The correlation of MMP-2 polymorphisms and stroke Int J Clin Exp Med (2016) 9, 4460-4466. M

2015

Abbasi,M., Ramezani,F., Elyasi,M., Sadeghi-Aliabadi,H. and Amanlou,M. A study on quantitative structure-activity relationship and molecular docking of metalloproteinase inhibitors based on L-tyrosine scaffold Daru (2015) 23, 29- PubMed Europe PubMed DOI PMC EPMC I
Bauters,D., Scroyen,I., Van Hul,M. and Lijnen,H.R. Gelatinase A (MMP-2) promotes murine adipogenesis Biochim Biophys Acta (2015) 1850, 1449-1456. PubMed Europe PubMed DOI K
Behrends,M., Wagner,S., Kopka,K., Schober,O., Schafers,M., Kumbhar,S., Waller,M. and Haufe,G. New matrix metalloproteinase inhibitors based on gamma-fluorinated alpha-aminocarboxylic and alpha-aminohydroxamic acids Bioorg Med Chem (2015) 23, 3809-3818. PubMed Europe PubMed DOI I
Bianchini,F., Calugi,C., Ruzzolini,J., Menchi,G., Calorini,L., Guarna,A. and Trabocchi,A. A study of a d-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9 MedChemComm (2015) 6, 277-282. DOI I
Diaz,N. and Suarez,D. Extensive simulations of the full-length matrix metalloproteinase-2 enzyme in a prereactive complex with a collagen triple-helical peptide Biochemistry (2015) 54, 1243-1258. PubMed Europe PubMed DOI
Gasparovic,I., Cizmarevic,N.S., Lovrecic,L., Perkovic,O., Lavtar,P., Sepcic,J., Jazbec,S.S., Kapovic,M., Peterlin,B. and Ristic,S. MMP-2 -1575G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS? J Neuroimmunol (2015) 286, 13-15. PubMed Europe PubMed DOI M
Gupta,B., Mai,K., Lowe,S.B., Wakefield,D., Di Girolamo,N., Gaus,K., Reece,P.J. and Gooding,J.J. Ultrasensitive and specific measurement of protease activity using functionalized photonic crystals Anal Chem (2015) 87, 9946-9953. PubMed Europe PubMed DOI A
Hadler-Olsen,E., Solli,A.I., Hafstad,A., Winberg,J.O. and Uhlin-Hansen,L. Intracellular MMP-2 activity in skeletal muscle is associated with type II fibers J Cell Physiol (2015) 230, 160-169. PubMed Europe PubMed DOI
Liu,Q., Pan,D., Cheng,C., Zhang,A., Ma,C., Wang,L., Zhang,D., Liu,H., Jiang,H., Wang,T., Xu,Y., Yang,R., Chen,F., Yang,M. and Zuo,C. Targeting of MMP2 activity in malignant tumors with a 68Ga-labeled gelatinase inhibitor cyclic peptide Nucl Med Biol (2015) 42, 939-944. PubMed Europe PubMed DOI L
Nanjan,P., Nambiar,J., Nair,B.G. and Banerji,A. Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9 Bioorg Med Chem (2015) 23, 3781-3787. PubMed Europe PubMed DOI I
Nuti,E., Cantelmo,A.R., Gallo,C., Bruno,A., Bassani,B., Camodeca,C., Tuccinardi,T., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Martinelli,A., Dive,V., Albini,A. and Rossello,A. N-O-Isopropyl sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors: hit selection and in vivo antiangiogenic activity J Med Chem (2015) 58, 7224-7240. PubMed Europe PubMed DOI I
Santamaria,S., Nuti,E., Cercignani,G., La Regina,G., Silvestri,R., Supuran,C.T. and Rossello,A. Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors J Enzyme Inhib Med Chem (2015) 30, 947-954. PubMed Europe PubMed DOI I
Shen,M., Lee,J., Basu,R., Sakamuri,S.S., Wang,X., Fan,D. and Kassiri,Z. Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm Arterioscler Thromb Vasc Biol (2015) 35, 888-898. PubMed Europe PubMed DOI K
Tveitaras,M.K., Skogstrand,T., Leh,S., Helle,F., Iversen,B.M., Chatziantoniou,C., Reed,R.K. and Hultstrom,M. Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction PLoS ONE (2015) 10, e0143390-e0143390. PubMed Europe PubMed DOI K
Vasilevskaya,T., Khrenova,M.G., Nemukhin,A.V. and Thiel,W. Mechanism of proteolysis in matrix metalloproteinase-2 revealed by QM/MM modeling J Comput Chem (2015) 36, 1621-1630. PubMed Europe PubMed DOI
Wang,P.F., Qiu,H.Y., Baloch,S.K., Gong,H.B., Wang,Z.C. and Zhu,H.L. Synthesis, biological evaluation, and docking of dihydropyrazole sulfonamide containing 2-hydroxyphenyl moiety: a series of novel MMP-2 inhibitors Chem Biol Drug Des (2015) 86, 1405-1410. PubMed Europe PubMed DOI I
Wang,X., Berry,E., Hernandez-Anzaldo,S., Sun,D., Adijiang,A., Li,L., Zhang,D. and Fernandez-Patron,C. MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells FEBS Lett (2015) 589, 490-496. PubMed Europe PubMed DOI
Wanga,S., Ceron,C.S., Delgado,C., Joshi,S.K., Spaulding,K., Walker,J.P., Song,S., Olson,J.L. and Lovett,D.H. Two distinct isoforms of matrix metalloproteinase-2 are associated with human delayed kidney graft function PLoS ONE (2015) 10, e0136276-e0136276. PubMed Europe PubMed DOI R
Yan,X.Q., Wang,Z.C., Li,Z., Wang,P.F., Qiu,H.Y., Chen,L.W., Lu,X.Y., Lv,P.C. and Zhu,H.L. Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: design, synthesis, inhibitory activity and 3D-QSAR analysis Bioorg Med Chem Lett (2015) 25, 4664-4671. PubMed Europe PubMed DOI I
Zapico,J.M., Puckowska,A., Filipiak,K., Coderch,C., de Pascual-Teresa,B. and Ramos,A. Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family Org Biomol Chem (2015) 13, 142-156. PubMed Europe PubMed DOI I

2014

Bencsik,P., Paloczi,J., Kocsis,G.F., Pipis,J., Belecz,I., Varga,Z.V., Csonka,C., Gorbe,A., Csont,T. and Ferdinandy,P. Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective Pharmacol Res (2014) 80, 36-42. PubMed Europe PubMed DOI I
Ekbote,A.V., Danda,S., Zankl,A., Mandal,K., Maguire,T. and Ungerer,K. Patient with mutation in the matrix metalloproteinase 2 (MMP2) gene - a case report and review of the literature J Clin Res Pediatr Endocrinol (2014) 6, 40-46. PubMed Europe PubMed DOI M
Fabre,B., Filipiak,K., Diaz,N., Zapico,J.M., Suarez,D., Ramos,A. and de Pascual-Teresa,B. An integrated computational and experimental approach to gaining selectivity for MMP-2 within the gelatinase subfamily Chembiochem (2014) 15, 399-412. PubMed Europe PubMed DOI I
Fan,G.C., Han,L., Zhu,H., Zhang,J.R. and Zhu,J.J. Ultrasensitive photoelectrochemical immunoassay for matrix metalloproteinase-2 detection based on CdS:Mn/CdTe cosensitized TiO2 nanotubes and signal amplification of SiO2@Ab2 conjugates Anal Chem (2014) 86, 12398-12405. PubMed Europe PubMed DOI A L
Filipiak,K., Kubinski,K., Hellman,U., Ramos,A. and de Pascual-Teresa,B. Human protein kinase CK2 phosphorylates matrix metalloproteinase 2 and inhibits its activity Chembiochem (2014) 15, 1873-1876. PubMed Europe PubMed DOI
Gaublomme,D., Buyens,T., De Groef,L., Stakenborg,M., Janssens,E., Ingvarsen,S., Porse,A., Behrendt,N. and Moons,L. Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells J Neurochem (2014) 129, 966-979. PubMed Europe PubMed DOI
Hua,D., Kong,W., Zheng,X., Zhou,Z., Yu,B., Li,Y., Wang,Y., Yang,X., Liu,C., Tang,L., Li,Y. and Gong,M. Potent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics Drug Des Devel Ther (2014) 8, 1839-1849. PubMed Europe PubMed DOI PMC EPMC
Hughes,B.G., Fan,X., Cho,W.J. and Schulz,R. MMP-2 is localized to the mitochondria-associated membrane of the heart Am J Physiol Heart Circ Physiol (2014) 306, H764-H770. PubMed Europe PubMed DOI
Iwao,Y., Shiga,K., Shiroshita,A., Yoshikawa,T., Sakiie,M., Ueno,T., Ueno,S., Ijiri,T.W. and Sato,K.-I. The need of MMP-2 on the sperm surface for Xenopus fertilization: its role in a fast electrical block to polyspermy Mech Dev (2014) 134, 80-95. PubMed Europe PubMed DOI
Kang,S.G., Araya-Secchi,R., Wang,D., Wang,B., Huynh,T. and Zhou,R. Dual inhibitory pathways of metallofullerenol Gd@C82(OH)22 on matrix metalloproteinase-2: molecular insight into drug-like nanomedicine Sci Rep (2014) 4, 4775-4775. PubMed Europe PubMed DOI PMC EPMC I
Kuntze,L.B., Antonio,R.C., Izidoro-Toledo,T.C., Meschiari,C.A., Tanus-Santos,J.E. and Gerlach,R.F. Captopril and lisinopril only inhibit matrix metalloproteinase-2 (MMP-2) activity at millimolar concentrations Basic Clin Pharmacol Toxicol (2014) 114, 233-239. PubMed Europe PubMed DOI I
Lauer,J.L., Bhowmick,M., Tokmina-Roszyk,D., Lin,Y., Van Doren,S.R. and Fields,G.B. The role of collagen charge clusters in the modulation of matrix metalloproteinase activity J Biol Chem (2014) 289, 1981-1992. PubMed Europe PubMed DOI P
Marcial,B.L., Sousa,S.F., Santos,H.F. and Ramos,M.J. Structural and dynamics analysis of matrix metalloproteinases MMP-2 complexed with chemically modified tetracyclines (CMTs) J Biomol Struct Dyn (2014) 32, 1907-1918. PubMed Europe PubMed DOI I
Qiu,H.-Y., Wang,Z.-C., Wang,P.-F., Yan,X.-Q., Wang,X.-M., Yang,Y.-H. and Zhu,H.-L. Design, synthesis, evaluation and 3D-QSAR analysis of benzosulfonamide benzenesulfonates as potent and selective inhibitors of MMP-2 RSC Adv (2014) 4, 39214-39225. DOI I
Rossano,R., Larocca,M., Riviello,L., Coniglio,M.G., Vandooren,J., Liuzzi,G.M., Opdenakker,G. and Riccio,P. Heterogeneity of serum gelatinases MMP-2 and MMP-9 isoforms and charge variants J Cell Mol Med (2014) 18, 242-252. PubMed Europe PubMed DOI
van Duijnhoven,S.M., Robillard,M.S., Hermann,S., Kuhlmann,M.T., Schafers,M., Nicolay,K. and Grull,H. Imaging of MMP activity in postischemic cardiac remodeling using radiolabeled MMP-2/9 activatable peptide probes Mol Pharm (2014) 11, 1415-1423. PubMed Europe PubMed DOI L
Verma,A., Rizvi,S.M., Shaikh,S., Ansari,M.A., Shakil,S., Ghazal,F., Siddiqui,M.H., Haneef,M. and Rehman,A. Compounds isolated from Ageratum houstonianum inhibit the activity of matrix metalloproteinases (MMP-2 and MMP-9): an oncoinformatics study Pharmacogn Mag (2014) 10, 18-26. PubMed Europe PubMed DOI PMC EPMC I
Wang,C., Zhan,C.L., Cai,Q.F., Du,C.H., Liu,G.M., Su,W.J. and Cao,M.J. Expression and characterization of common carp (Cyprinus carpio) matrix metalloproteinase-2 and its activity against type I collagen J Biotechnol (2014) 177, 45-52. PubMed Europe PubMed DOI
Wang,Z., Li,X., Feng,D., Li,L., Shi,W. and Ma,H. Poly(m-phenylenediamine)-based fluorescent nanoprobe for ultrasensitive detection of matrix metalloproteinase 2 Anal Chem (2014) 86, 7719-7725. PubMed Europe PubMed DOI A L
Wu,J.L., Ge,S.Y., Cai,Z.X., Liu,H., Liu,Y.X., Wang,J.H. and Zhang,Q.Q. Purification and characterization of a gelatinolytic matrix metalloproteinase from the skeletal muscle of grass carp (Ctenopharyngodon idellus) Food Chem (2014) 145, 632-638. PubMed Europe PubMed DOI
Yari,K., Rahimi,Z., Moradi,M.T. and Rahimi,Z. The MMP-2 -735 C allele is a risk factor for susceptibility to breast cancer Asian Pac J Cancer Prev (2014) 15, 6199-6203. PubMed Europe PubMed M
Yari,K., Rahimi,Z., Moradi,M.-T. and Rahimi,Z. The MMP-2-735 C allele is a risk factor for susceptibility to breast cancer Asian Pac J Cancer Prev (2014) 15, 6199-6203. DOI M
Yue,X., Wang,Z., Zhu,L., Wang,Y., Qian,C., Ma,Y., Kiesewetter,D.O., Niu,G. and Chen,X. Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS Mol Pharm (2014) 11, 4208-4217. PubMed Europe PubMed DOI L
Zhang,J., Li,X., Jiang,Y., Feng,J., Li,X., Zhang,Y. and Xu,W. Design, synthesis and preliminary evaluation of alpha-sulfonyl gamma-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors Bioorg Med Chem (2014) 22, 3055-3064. PubMed Europe PubMed DOI I
Zhang,X., Bresee,J., Cheney,P.P., Xu,B., Bhowmick,M., Cudic,M., Fields,G.B. and Edwards,W.B. Evaluation of a triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity Molecules (2014) 19, 8571-8588. PubMed Europe PubMed DOI L
Zhang,X., Bresee,J., Fields,G.B. and Edwards,W.B. Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo Bioorg Med Chem Lett (2014) 24, 3786-3790. PubMed Europe PubMed DOI L

2013

Alcantara,M.B. and Dass,C.R. Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer Cell Physiol Biochem (2013) 31, 487-494. PubMed Europe PubMed DOI
Casalini,F., Fugazza,L., Esposito,G., Cabella,C., Brioschi,C., Cordaro,A., D'Angeli,L., Bartoli,A., Filannino,A.M., Gringeri,C.V., Longo,D.L., Muzio,V., Nuti,E., Orlandini,E., Figlia,G., Quattrini,A., Tei,L., Digilio,G., Rossello,A. and Maiocchi,A. Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography J Med Chem (2013) 56, 2676-2689. PubMed Europe PubMed DOI L I
Castro,M.M., Fuah,J., Ali,M., Sung,M., Schulz,J., Kondo,M.Y., Fan,X., Holt,A. and Schulz,R. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2 Biochem Pharmacol (2013) 86, 469-475. PubMed Europe PubMed DOI I
Diaz,N., Suarez,D. and Valdes,H. Unraveling the molecular structure of the catalytic domain of matrix metalloproteinase-2 in complex with a triple-helical peptide by means of molecular dynamics simulations Biochemistry (2013) 52, 8556-8569. PubMed Europe PubMed DOI
Fabre,B., Filipiak,K., Zapico,J.M., Diaz,N., Carbajo,R.J., Schott,A.K., Martinez-Alcazar,M.P., Suarez,D., Pineda-Lucena,A., Ramos,A. and de Pascual-Teresa,B. Progress towards water-soluble triazole-based selective MMP-2 inhibitors Org Biomol Chem (2013) 11, 6623-6641. PubMed Europe PubMed DOI I
Freskos,J.N., Asmelash,B., Gaston,K.R., Karwa,A., Marzan,T.A., Nickols,M.A., Rogers,T.E., Schoenstein,T., Sympson,C.J. and Vu,B. Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes Bioorg Med Chem Lett (2013) 23, 5566-5570. PubMed Europe PubMed DOI L I
Givvimani,S., Kundu,S., Narayanan,N., Armaghan,F., Qipshidze,N., Pushpakumar,S., Vacek,T.P. and Tyagi,S.C. TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV dysfunction and heart failure Arch Physiol Biochem (2013) 119, 65-74. PubMed Europe PubMed DOI K
Gooyit,M., Song,W., Mahasenan,K.V., Lichtenwalter,K., Suckow,M.A., Schroeder,V.A., Wolter,W.R., Mobashery,S. and Chang,M. O-Phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier J Med Chem (2013) 56, 8139-8150. PubMed Europe PubMed DOI I
Halder,A.K., Saha,A. and Jha,T. Exploring QSAR and pharmacophore mapping of structurally diverse selective matrix metalloproteinase-2 inhibitors J Pharm Pharmacol (2013) 65, 1541-1554. PubMed Europe PubMed DOI I
Higashi,S., Hirose,T., Takeuchi,T. and Miyazaki,K. Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2) J Biol Chem (2013) 288, 9066-9076. PubMed Europe PubMed DOI
Hugenberg,V., Riemann,B., Hermann,S., Schober,O., Schafers,M., Szardenings,K., Lebedev,A., Gangadharmath,U., Kolb,H., Walsh,J., Zhang,W., Kopka,K. and Wagner,S. Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (Radio)synthesis, in vitro and first in vivo evaluation J Med Chem (2013) 56, 6858-6870. PubMed Europe PubMed DOI I
Jacob-Ferreira,A.L. and Schulz,R. Activation of intracellular matrix metalloproteinase-2 by reactive oxygen-nitrogen species: consequences and therapeutic strategies in the heart Arch Biochem Biophys (2013) 540, 82-93. PubMed Europe PubMed DOI
Ji,M.K., Shi,Y., Xu,J.W., Lin,X. and Lin,J.Y. Recombinant snake venom metalloproteinase inhibitor BJ46A inhibits invasion and metastasis of B16F10 and MHCC97H cells through reductions of matrix metalloproteinases 2 and 9 activities Anticancer Drugs (2013) 24, 461-472. PubMed Europe PubMed DOI E U
Kreituss,I., Rozenberga,E., Zemitis,J., Trapencieris,P., Romanchikova,N. and Turks,M. Discovery of aziridine-triazole conjugates as selective MMP-2 inhibitors Chem Heterocycl Compd (2013) 49, 1108-1117. DOI I
Lovett,D.H., Mahimkar,R., Raffai,R.L., Cape,L., Zhu,B.Q., Jin,Z.Q., Baker,A.J. and Karliner,J.S. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure PLoS ONE (2013) 8, e68154-e68154. PubMed Europe PubMed DOI PMC EPMC
Marques,S.M., Abate,C.C., Chaves,S., Marques,F., Santos,I., Nuti,E., Rossello,A. and Santos,M.A. New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy J Inorg Biochem (2013) 127, 188-202. PubMed Europe PubMed DOI I
Pizio,A.D., Laghezza,A., Tortorella,P. and Agamennone,M. Probing the S1' site for the identification of non-zinc-binding MMP-2 inhibitors ChemMedChem (2013) 8, 1475-1482. PubMed Europe PubMed DOI I
Rastogi,A., Kim,H., Twomey,J.D. and Hsieh,A.H. MMP-2 mediates local degradation and remodeling of collagen by annulus fibrosus cells of the intervertebral disc Arthritis Res Ther (2013) 15, R57-R57. PubMed Europe PubMed DOI
Ryu,J.H., Shin,J.Y., Kim,S.A., Kang,S.W., Kim,H., Kang,S., Choi,K., Kwon,I.C., Kim,B.S. and Kim,K. Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model Biomaterials (2013) 34, 6871-6881. PubMed Europe PubMed DOI L
Shi,Z.H., Li,N.G., Shi,Q.P., Tang,H., Tang,Y.P., Li,W., Yin,L., Yang,J.P. and Duan,J.A. Design, synthesis and biological evaluation of ferulic acid amides as selective matrix metalloproteinase inhibitors Med Chem (2013) 9, 947-954. PubMed Europe PubMed DOI I
Takahashi,T., Fujimori,C., Hagiwara,A. and Ogiwara,K. Recent advances in the understanding of teleost medaka ovulation: the roles of proteases and prostaglandins Zoolog Sci (2013) 30, 239-247. PubMed Europe PubMed DOI
Tauro,M., Laghezza,A., Loiodice,F., Agamennone,M., Campestre,C. and Tortorella,P. Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors Bioorg Med Chem (2013) 21, 6456-6465. PubMed Europe PubMed DOI I
Verslegers,M., Lemmens,K., Van Hove,I. and Moons,L. Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system Prog Neurobiol (2013) 105, 60-78. PubMed Europe PubMed DOI V
Yoon,H.K. and Yoo,T.H. A novel protease activity assay method based on an engineered autoinhibited protein using an enzyme-linked immunoassay Analyst (2013) 138, 7164-7168. PubMed Europe PubMed DOI A
Zheng,T., Zhang,R., Zhang,Q., Tan,T., Zhang,K., Zhu,J.J. and Wang,H. Ultrasensitive dual-channel detection of matrix metalloproteinase-2 in human serum using gold-quantum dot core-satellite nanoprobes Chem Commun (Camb) (2013) 49, 7881-7883. PubMed Europe PubMed DOI A
Zhong,H.A., Arbiser,J. and Bowen,J.P. Selectivity, binding affinity, and ionization state of matrix metalloproteinase inhibitors Curr Pharm Des (2013) 19, 4701-4713. PubMed Europe PubMed DOI I

2012

Alam,M., Ali,S.A., Abbasi,A., Kalbacher,H. and Voelter,W. Design and synthesis of a peptidyl-FRET substrate for tumor marker enzyme human matrix metalloprotease-2 (hMMP-2) Int J Pept Res Ther (2012) 18, 207-215. DOI A
Ali,M.A., Chow,A.K., Kandasamy,A.D., Fan,X., West,L.J., Crawford,B.D., Simmen,T. and Schulz,R. Mechanisms of cytosolic targeting of matrix metalloproteinase-2 J Cell Physiol (2012) 227, 3397-3404. PubMed Europe PubMed DOI
Bu,Z., Pan,Y., Shang,B., Cao,Z., Zhou,Q. and Ruan,C. SZ-117, a monoclonal antibody against matrix metalloproteinase-2 inhibits tumor cell-mediated angiogenesis Hybridoma (Larchmt) (2012) 31, 63-67. PubMed Europe PubMed DOI
Burkhart,J.L., Diehl,B., Schmitt,M.J. and Kazmaier,U. A straightforward approach to MMP-2 and MMP-9 inhibitors based on chelate claisen rearrangements Eur J Org Chem (2012) 2012, 567-575. DOI I
Cheng,X.C., Wang,R.L., Dong,Z.K., Li,J., Li,Y.Y. and Li,R.R. Design, synthesis and evaluation of novel metalloproteinase inhibitors based on l-tyrosine scaffold Bioorg Med Chem (2012) 20, 5738-5744. PubMed Europe PubMed DOI I
Christianson,C.A., Fitzsimmons,B.L., Shim,J.H., Agrawal,A., Cohen,S.M., Hua,X.Y. and Yaksh,T.L. Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism Neuroscience (2012) 200, 199-210. PubMed Europe PubMed DOI I
Chuang,C.H., Chuang,K.H., Wang,H.E., Roffler,S.R., Shiea,J.T., Tzou,S.C., Cheng,T.C., Kao,C.H., Wu,S.Y., Tseng,W.L., Cheng,C.M., Hou,M.F., Wang,J.M. and Cheng,T.L. In vivo positron emission tomography imaging of protease activity by generation of a hydrophobic product from a noninhibitory protease substrate Clin Cancer Res (2012) 18, 238-247. PubMed Europe PubMed DOI L
de Melo,E.B. A QSAR study of matrix metalloproteinases type 2 (MMP-2) inhibitors with cinnamoyl pyrrolidine derivatives Sci Pharm (2012) 80, 265-281. PubMed Europe PubMed DOI PMC EPMC I
Detry,B., Erpicum,C., Paupert,J., Blacher,S., Maillard,C., Bruyere,F., Pendeville,H., Remacle,T., Lambert,V., Balsat,C., Ormenese,S., Lamaye,F., Janssens,E., Moons,L., Cataldo,D., Kridelka,F., Carmeliet,P., Thiry,M., Foidart,J.M., Struman,I. and Noel,A. Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase Blood (2012) 119, 5048-5056. PubMed Europe PubMed DOI
Di Pizio,A., Agamennone,M. and Aschi,M. An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors PLoS ONE (2012) 7, e47774-e47774. PubMed Europe PubMed DOI PMC EPMC I
Frankowski,H., Gu,Y.H., Heo,J.H., Milner,R. and del Zoppo,G.J. Use of gel zymography to examine matrix metalloproteinase (gelatinase) expression in brain tissue or in primary glial cultures Methods Mol Biol (2012) 814, 221-233. PubMed Europe PubMed DOI A
Harney,A.S., Sole,L.B. and Meade,T.J. Kinetics and thermodynamics of irreversible inhibition of matrix metalloproteinase2 by a Co(III) Schiff base complex J Biol Inorg Chem (2012) 17, 853-860. PubMed Europe PubMed DOI I
Koo,B.H., Kim,Y.H., Han,J.H. and Kim,D.S. Dimerization of matrix metalloproteinase-2 (MMP-2): functional implication in MMP-2 activation J Biol Chem (2012) 287, 22643-22653. PubMed Europe PubMed DOI
Lacchini,R., Jacob-Ferreira,A.L., Luizon,M.R., Gasparini,S., Ferreira-Sae,M.C., Schreiber,R., Nadruz,W., Jr. and Tanus-Santos,J.E. Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients J Hum Hypertens (2012) 26, 171-177. PubMed Europe PubMed DOI M
Marcial,B.L., Sousa,S.F., Barbosa,I.L., Dos Santos,H.F. and Ramos,M.J. Chemically modified tetracyclines as inhibitors of MMP-2 matrix metalloproteinase: a molecular and structural study J Phys Chem B (2012) 116, 13644-13654. PubMed Europe PubMed DOI I
Mikhailova,M., Xu,X., Robichaud,T.K., Pal,S., Fields,G.B. and Steffensen,B. Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2) Matrix Biol (2012) 31, 380-388. PubMed Europe PubMed DOI
Murphy,G. Matrix metallopeptidase-2/gelatinase A [ISSN:978-0-12-407744-7] (2012) 3, 747-753. DOI
Nicolotti,O., Catto,M., Giangreco,I., Barletta,M., Leonetti,F., Stefanachi,A., Pisani,L., Cellamare,S., Tortorella,P., Loiodice,F. and Carotti,A. Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 Eur J Med Chem (2012) 58, 368-376. PubMed Europe PubMed DOI I
Peng,H., Wu,Y., Duan,Z., Ciborowski,P. and Zheng,J.C. Proteolytic processing of SDF-1alpha by matrix metalloproteinase-2 impairs CXCR4 signaling and reduces neural progenitor cell migration Protein Cell (2012) 3, 875-882. PubMed Europe PubMed DOI
Rah,B., Amin,H., Yousuf,K., Khan,S., Jamwal,G., Mukherjee,D. and Goswami,A. A novel MMP-2 inhibitor 3-azidowithaferin A (3-azidoWA) abrogates cancer cell invasion and angiogenesis by modulating extracellular Par-4 PLoS ONE (2012) 7, e44039-e44039. PubMed Europe PubMed DOI PMC EPMC I
Serra,P., Bruczko,M., Zapico,J.M., Puckowska,A., Garcia,M.A., Martin-Santamari,S., Ramos,A. and de Pascual-Teresa,B. MMP-2 selectivity in hydroxamate-type inhibitors Curr Med Chem (2012) 19, 1036-1064. PubMed Europe PubMed I
Shi,Z.H., Li,N.G., Shi,Q.P., Hao,T. and Tang,Y.P. Design, synthesis, and preliminary evaluation of substituted cinnamic acid esters as selective matrix metalloproteinase inhibitors Drug Dev Res (2012) 73, 317-324. DOI I
Tanakit,A., Rouffet,M., Martin,D.P. and Cohen,S.M. Investigating chelating sulfonamides and their use in metalloproteinase inhibitors Dalton Trans (2012) 41, 6507-6515. PubMed Europe PubMed DOI I
Thiolloy,S., Edwards,J.R., Fingleton,B., Rifkin,D.B., Matrisian,L.M. and Lynch,C.C. An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment PLoS ONE (2012) 7, e29862-e29862. PubMed Europe PubMed DOI PMC EPMC
Topai,A., Breccia,P., Minissi,F., Padova,A., Marini,S. and Cerbara,I. In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors Bioorg Med Chem (2012) 20, 2323-2337. PubMed Europe PubMed DOI I
Verhille,M., Benachour,H., Ibrahim,A., Achard,M., Arnoux,P., Barberi-Heyob,M., Andre,J.C., Allonas,X., Baros,F., Vanderesse,R. and Frochot,C. Photodynamic molecular beacons triggered by MMP-2 and MMP-9: influence of the distance between photosensitizer and quencher onto photophysical properties and enzymatic activation Curr Med Chem (2012) 19, 5580-5594. PubMed Europe PubMed DOI A
Wang,N., Zhu,M., Tsao,S.W., Man,K., Zhang,Z. and Feng,Y. Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma PLoS ONE (2012) 7, e46318-e46318. PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Shen,P., Li,C., Wang,Y. and Liu,Z. Upconversion fluorescence resonance energy transfer based biosensor for ultrasensitive detection of matrix metalloproteinase-2 in blood Anal Chem (2012) 84, 1466-1473. PubMed Europe PubMed DOI A
Yamamoto,D., Takai,S., Akimoto,T., Hirahara,I., Ito,C., Muto,S. and Kusano,E. Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport Clin Exp Pharmacol Physiol (2012) 39, 864-868. PubMed Europe PubMed DOI I
Yamamoto,N., Bryce,N.S., Metzler-Nolte,N. and Hambley,T.W. Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids Bioconjug Chem (2012) 23, 1110-1118. PubMed Europe PubMed DOI

2011

Choi,S.S., Ji,A.R., Yu,S.W., Cho,B.H., Park,J.D., Park,J.H., Lee,H.S., Ryu,S.E., Kim,D.H., Kang,J.H. and Lee,S.T. Inhibition of invasion and capillary-like tube formation by retrohydroxamate-based MMP inhibitors Bull Korean Chem Soc (2011) 32, 2032-2038. DOI I
Diehl,B., Hoffmann,T.M., Mueller,N.C., Burkhart,J.L., Kazmaier,U. and Schmitt,M.J. Novel yeast bioassay for high-throughput screening of matrix metalloproteinase inhibitors Appl Environ Microbiol (2011) 77, 8573-8577. PubMed Europe PubMed DOI I
Feng,D., Zhang,Y., Feng,T., Shi,W., Li,X. and Ma,H. A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matrix metalloproteinase 2 Chem Commun (Camb) (2011) 47, 10680-10682. PubMed Europe PubMed DOI A
Giangreco,I., Lattanzi,G., Nicolotti,O., Catto,M., Laghezza,A., Leonetti,F., Stefanachi,A. and Carotti,A. Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations PLoS ONE (2011) 6, e25597-e25597. PubMed Europe PubMed DOI PMC EPMC I
Jo,Y.K., Park,S.J., Shin,J.H., Kim,Y., Hwang,J.J., Cho,D.H. and Kim,J.C. ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells Biochem Biophys Res Commun (2011) 404, 1039-1043. PubMed Europe PubMed DOI I
Liu,X. Emerging ideas: matrix metalloproteinase-2 in muscle atrophy Clin Orthop Relat Res (2011) 469, 1797-1799. PubMed Europe PubMed DOI
Moroy,G., Bourguet,E., Decarme,M., Sapi,J., Alix,A.J., Hornebeck,W. and Lorimier,S. Inhibition of human leukocyte elastase, plasmin and matrix metalloproteinases by oleic acid and oleoyl-galardin derivative(s) Biochem Pharmacol (2011) 81, 626-635. PubMed Europe PubMed DOI I
Robichaud,T.K., Steffensen,B. and Fields,G.B. Exosite interactions impact matrix metalloproteinase collagen specificities J Biol Chem (2011) 286, 37535-37542. PubMed Europe PubMed DOI P
Saygili,E., Schauerte,P., Pekassa,M., Saygili,E., Rackauskas,G., Schwinger,R.H.G., Weis,J., Weber,C., Marx,N. and Rana,O.R. Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion Cell Mol Neurobiol (2011) 31, 17-25. PubMed Europe PubMed DOI
Testero,S.A., Lee,M., Staran,R.T., Espahbodi,M., Llarrull,L.I., Toth,M., Mobashery,S. and Chang,M. Sulfonate-containing thiiranes as selective gelatinase inhibitors ACS Med Chem Lett (2011) 2, 177-181. PubMed Europe PubMed DOI I
Testero,S.A., Llarrull,L.I., Fisher,J.F., Chang,M. and Mobashery,S. Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry Arkivoc (2011) 2011, 221-236. I
Tremblay,P., Beaudet,M.J., Tremblay,E., Rueda,N., Thomas,T. and Vallieres,L. Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair J Pathol (2011) 224, 222-233. PubMed Europe PubMed DOI
Wang,J., Medina,C., Radomski,M.W. and Gilmer,J.F. N-Substituted homopiperazine barbiturates as gelatinase inhibitors Bioorg Med Chem (2011) 19, 4985-4999. PubMed Europe PubMed DOI I
Westermann,D., Savvatis,K., Lindner,D., Zietsch,C., Becher,P.M., Hammer,E., Heimesaat,M.M., Bereswill,S., Volker,U., Escher,F., Riad,A., Plendl,J., Klingel,K., Poller,W., Schultheiss,H.P. and Tschope,C. Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy Circulation (2011) 124, 2082-2093. PubMed Europe PubMed DOI K
Wilson,L.J., Wang,B., Yang,S.M., Scannevin,R.H., Burke,S.L., Karnachi,P., Rhodes,K.J. and Murray,W.V. Discovery of novel cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy Bioorg Med Chem Lett (2011) 21, 6485-6490. PubMed Europe PubMed DOI I
Xu,X., Mikhailova,M., Chen,Z., Pal,S., Robichaud,T.K., Lafer,E.M., Baber,S. and Steffensen,B. Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2) Matrix Biol (2011) 30, 404-412. PubMed Europe PubMed DOI
Zapico,J., Serra,P., Sanmartin,J.G., Filipiak,K., Martinez,A., Santamaria,S.M., de Pascual-Teresa,B. and Ramos,A. Synthesis of selective MMP-2 inhibitors using click chemistry An R Acad Farm (2011) 77, 99-117. I

2010

Ali,M.A., Cho,W.J., Hudson,B., Kassiri,Z., Granzier,H. and Schulz,R. Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury Circulation (2010) 122, 2039-2047. PubMed Europe PubMed DOI
Becker,D.P., Barta,T.E., Bedell,L.J., Boehm,T.L., Bond,B.R., Carroll,J., Carron,C.P., Decrescenzo,G.A., Easton,A.M., Freskos,J.N., Funckes-Shippy,C.L., Heron,M., Hockerman,S., Howard,C.P., Kiefer,J.R., Li,M.H., Mathis,K.J., McDonald,J.J., Mehta,P.P., Munie,G.E., Sunyer,T., Swearingen,C.A., Villamil,C.I., Welsch,D., Williams,J.M., Yu,Y. and Yao,J. Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease J Med Chem (2010) 53, 6653-6680. PubMed Europe PubMed DOI I
Bruni-Cardoso,A., Lynch,C.C., Rosa-Ribeiro,R., Matrisian,L.M. and Carvalho,H.F. MMP-2 contributes to the development of the mouse ventral prostate by impacting epithelial growth and morphogenesis Dev Dyn (2010) 239, 2386-2392. PubMed Europe PubMed DOI K
Emara,M. and Wozniak,M. In vitro inhibition of human MMP-2 collagenolytic and gelatinolytic activity by neutralizing monoclonal antibodies Immunol Invest (2010) 39, 833-848. PubMed Europe PubMed DOI
Gioia,M., Fasciglione,G.F., Monaco,S., Iundusi,R., Sbardella,D., Marini,S., Tarantino,U. and Coletta,M. pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain J Biol Inorg Chem (2010) 15, 1219-1232. PubMed Europe PubMed DOI
Hernandez-Guillamon,M., Mawhirt,S., Fossati,S., Blais,S., Pares,M., Penalba,A., Boada,M., Couraud,P.O., Neubert,T.A., Montaner,J., Ghiso,J. and Rostagno,A. Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells J Biol Chem (2010) 285, 27144-27158. PubMed Europe PubMed DOI
Kim,J.H. and Chung,B.H. Proteolytic fluorescent signal amplification on gold nanoparticles for a highly sensitive and rapid protease assay Small (2010) 6, 126-131. PubMed Europe PubMed DOI A
Linke,W.A. Molecular giant vulnerable to oxidative damage: titin joins the club of proteins degraded by matrix metalloproteinase-2 Circulation (2010) 122, 2002-2004. PubMed Europe PubMed DOI
Manso,H., Krug,T., Sobral,J., Albergaria,I., Gaspar,G., Ferro,J.M., Oliveira,S.A. and Vicente,A.M. Variants of the matrix metalloproteinase-2 but not the matrix metalloproteinase-9 genes significantly influence functional outcome after stroke BMC Med Genet (2010) 11, 40-40. PubMed Europe PubMed DOI M
Tao,P., Fisher,J.F., Shi,Q., Mobashery,S. and Schlegel,H.B. Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT J Phys Chem B (2010) 114, 1030-1037. PubMed Europe PubMed DOI I
Ulmer,T.A., Keeler,V., Andre,S., Gabius,H.J., Loh,L. and Laferte,S. The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic cleavage Biochim Biophys Acta (2010) 1800, 336-343. PubMed Europe PubMed DOI

2009

Burns,D.M., Li,Y.L., Shi,E., He,C., Xu,M., Zhuo,J., Zhang,C., Qian,D.Q., Li,Y., Wynn,R., Covington,M.B., Katiyar,K., Marando,C.A., Fridman,J.S., Scherle,P., Friedman,S., Metcalf,B. and Yao,W. Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition Bioorg Med Chem Lett (2009) 19, 3525-3530. PubMed Europe PubMed DOI I
Carvalho,R.V., Ogliari,F.A., de Souza,A.P., Silva,A.F., Petzhold,C.L., Line,S.R., Piva,E. and Etges,A. 2-Hydroxyethyl methacrylate as an inhibitor of matrix metalloproteinase-2 Eur J Oral Sci (2009) 117, 64-67. PubMed Europe PubMed DOI I
Chaussain,C., Eapen,A.S., Huet,E., Floris,C., Ravindran,S., Hao,J., Menashi,S. and George,A. MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell Eur Cell Mater (2009) 18, 84-95. PubMed Europe PubMed
Forbes,C., Shi,Q., Fisher,J.F., Lee,M., Hesek,D., Llarrull,L.I., Toth,M., Gossing,M., Fridman,R. and Mobashery,S. Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases Chem Biol Drug Des (2009) 74, 527-534. PubMed Europe PubMed DOI PMC EPMC I
Gooyit,M., Lee,M., Hesek,D., Boggess,B., Oliver,A.G., Fridman,R., Mobashery,S. and Chang,M. Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors Chem Biol Drug Des (2009) 74, 535-546. PubMed Europe PubMed DOI I
Huang,H., Zhao,W., Tang,Z., Yang,S., Wu,Z., Zhao,S., Cui,W., Mu,Y., Chu,M. and Li,K. Characterization of porcine MMP-2 and its association with immune traits Gene (2009) 435, 63-71. PubMed Europe PubMed DOI
Jastrzebska,B., Lebel,R., Therriault,H., McIntyre,J.O., Escher,E., Guerin,B., Paquette,B., Neugebauer,W.A. and Lepage,M. New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging J Med Chem (2009) 52, 1576-1581. PubMed Europe PubMed DOI L
Jung,J.C., Wang,P.X., Zhang,G., Ezura,Y., Fini,M.E. and Birk,D.E. Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation Cell Tissue Res (2009) 336, 79-89. PubMed Europe PubMed DOI PMC EPMC
Kenny,H.A. and Lengyel,E. MMP-2 functions as an early response protein in ovarian cancer metastasis Cell Cycle (2009) 8, 683-688. PubMed Europe PubMed
Lee,M., Celenza,G., Boggess,B., Blase,J., Shi,Q., Toth,M., Bernardo,M.M., Wolter,W.R., Suckow,M.A., Hesek,D., Noll,B.C., Fridman,R., Mobashery,S. and Chang,M. A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition Chem Biol Drug Des (2009) 73, 189-202. PubMed Europe PubMed DOI PMC EPMC I
Lehmann,H.C., Kohne,A., Bernal,F., Jangouk,P., Meyer Zu Horste,G., Dehmel,T., Hartung,H.P., Previtali,S.C. and Kieseier,B.C. Matrix metalloproteinase-2 is involved in myelination of dorsal root ganglia neurons Glia (2009) 57, 479-489. PubMed Europe PubMed DOI
Murnane,M.J., Cai,J., Shuja,S., McAneny,D., Klepeis,V. and Willett,J.B. Active MMP-2 effectively identifies the presence of colorectal cancer Int J Cancer (2009) 125, 2893-2902. PubMed Europe PubMed DOI PMC EPMC
Song,J.H., Kim,S.H., Cho,D., Lee,I.K., Kim,H.J. and Kim,T.S. Enhanced invasiveness of drug-resistant acute myeloid leukemia cells through increased expression of matrix metalloproteinase-2 Int J Cancer (2009) 125, 1074-1081. PubMed Europe PubMed DOI
Tao,P., Fisher,J.F., Mobashery,S. and Schlegel,H.B. DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2 Org Lett (2009) 11, 2559-2562. PubMed Europe PubMed DOI I
Tao,P., Fisher,J.F., Shi,Q., Vreven,T., Mobashery,S. and Schlegel,H.B. Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue Biochemistry (2009) 48, 9839-9847. PubMed Europe PubMed DOI I
Tuysuz,B., Mosig,R., Altun,G., Sancak,S., Glucksman,M.J. and Martignetti,J.A. A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects Eur J Hum Genet (2009) 17, 565-572. PubMed Europe PubMed DOI PMC EPMC M
Viappiani,S., Nicolescu,A.C., Holt,A., Sawicki,G., Crawford,B.D., Leon,H., van Mulligen,T. and Schulz,R. Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione Biochem Pharmacol (2009) 77, 826-834. PubMed Europe PubMed DOI
Wang,W., Shao,R., Wu,Q., Ke,S., McMurray,J., Lang,F.F., Jr., Charnsangavej,C., Gelovani,J.G. and Li,C. Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide Mol Imaging Biol (2009) 11, 424-433. PubMed Europe PubMed DOI L I
Xu,X., Mikhailova,M., Ilangovan,U., Chen,Z., Yu,A., Pal,S., Hinck,A.P. and Steffensen,B. Nuclear magnetic resonance mapping and functional confirmation of the collagen binding sites of matrix metalloproteinase-2 Biochemistry (2009) 48, 5822-5831. PubMed Europe PubMed DOI PMC EPMC
Zhi,Y.H., Song,M.M., Wang,P.L., Zhang,T. and Yin,Z.Y. Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion World J Gastroenterol (2009) 15, 1072-1078. PubMed Europe PubMed DOI PMC EPMC T

2008

Celenza,G., Villegas-Estrada,A., Lee,M., Boggess,B., Forbes,C., Wolter,W.R., Suckow,M.A., Mobashery,S. and Chang,M. Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor Chem Biol Drug Des (2008) 71, 187-196. PubMed Europe PubMed DOI I
Cheng,X.C., Wang,Q., Fang,H., Tang,W. and Xu,W.F. Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors Eur J Med Chem (2008) 43, 2130-2139. PubMed Europe PubMed DOI I
Diaz,N. and Suarez,D. Peptide hydrolysis catalyzed by matrix metalloproteinase 2: a computational study J Phys Chem B (2008) 112, 8412-8424. PubMed Europe PubMed DOI
Diaz,N., Suarez,D. and Valdes,H. From the X-ray compact structure to the elongated form of the full-length MMP-2 enzyme in solution: a molecular dynamics study J Am Chem Soc (2008) 130, 14070-14071. PubMed Europe PubMed DOI S
Fert-Bober,J., Leon,H., Sawicka,J., Basran,R.S., Devon,R.M., Schulz,R. and Sawicki,G. Inhibiting matrix metalloproteinase-2 reduces protein release into coronary effluent from isolated rat hearts during ischemia-reperfusion Basic Res Cardiol (2008) 103, 431-443. PubMed Europe PubMed DOI
Higashi,S. and Miyazaki,K. Identification of amino acid residues of the matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor J Biol Chem (2008) 283, 10068-10078. PubMed Europe PubMed DOI
Ingvarsen,S., Madsen,D.H., Hillig,T., Lund,L.R., Holmbeck,K., Behrendt,N. and Engelholm,L.H. Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells Biol Chem (2008) 389, 943-953. PubMed Europe PubMed DOI
Lebel,R., Jastrzebska,B., Therriault,H., Cournoyer,M.M., McIntyre,J.O., Escher,E., Neugebauer,W., Paquette,B. and Lepage,M. Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model Magn Reson Med (2008) 60, 1056-1065. PubMed Europe PubMed DOI L
Lee,M., Hesek,D., Shi,Q., Noll,B.C., Fisher,J.F., Chang,M. and Mobashery,S. Conformational analyses of thiirane-based gelatinase inhibitors Bioorg Med Chem Lett (2008) 18, 3064-3067. PubMed Europe PubMed DOI I
Mukai,T., Suganuma,N., Soejima,K., Sasaki,J., Yamamoto,F. and Maeda,M. Synthesis of a beta-tetrapeptide analog as a mother compound for the development of matrix metalloproteinase-2-imaging agents Chem Pharm Bull (Tokyo) (2008) 56, 260-265. PubMed Europe PubMed DOI L I
Naidu,D.G., Tang,M. and Tabibzadeh,S. Lefty peptides, derived by MMP2 cleavage, act as a new class of gelatinase A inhibitor Front Biosci (2008) 13, 7193-7201. PubMed Europe PubMed
Nishida,Y., Miyamori,H., Thompson,E.W., Takino,T., Endo,Y. and Sato,H. Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2 Cancer Res (2008) 68, 9096-9104. PubMed Europe PubMed DOI
Rehault-Godbert,S., Gautron,J., Labas,V., Belghazi,M. and Nys,Y. Identification and characterization of the precursor of chicken matrix metalloprotease 2 (pro-MMP-2) in hen egg J Agric Food Chem (2008) 56, 6294-6303. PubMed Europe PubMed DOI
Tsung,A.J., Kargiotis,O., Chetty,C., Lakka,S.S., Gujrati,M., Spomar,D.G., Dinh,D.H. and Rao,J.S. Downregulation of matrix metalloproteinase-2 (MMP-2) utilizing adenovirus-mediated transfer of small interfering RNA (siRNA) in a novel spinal metastatic melanoma model Int J Oncol (2008) 32, 557-564. PubMed Europe PubMed PMC EPMC
Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Huang,Z., Karnachi,P., Wilson,L.J., Rhodes,K.J., Lagu,B. and Murray,W.V. beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents Bioorg Med Chem Lett (2008) 18, 1140-1145. PubMed Europe PubMed DOI I
Yang,S.M., Scannevin,R.H., Wang,B., Burke,S.L., Wilson,L.J., Karnachi,P., Rhodes,K.J., Lagu,B. and Murray,W.V. beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. design, synthesis, and lead identification Bioorg Med Chem Lett (2008) 18, 1135-1139. PubMed Europe PubMed DOI I
Zheng,J., Wen,R. and Guillaume,D. Three-dimensional quantitative structure-activity relationship (CoMFA and CoMSIA) studies on galardin derivatives as gelatinase A (matrix metalloproteinase 2) inhibitors J Enzyme Inhib Med Chem (2008) 23, 445-453. PubMed Europe PubMed DOI I

2007

Baraldo,S., Bazzan,E., Zanin,M.E., Turato,G., Garbisa,S., Maestrelli,P., Papi,A., Miniati,M., Fabbri,L.M., Zuin,R. and Saetta,M. Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression Chest (2007) 132, 1733-1740. PubMed Europe PubMed DOI
de Oliveira,C.A., Zissen,M., Mongon,J. and McCammon,J.A. Molecular dynamics simulations of metalloproteinases types 2 and 3 reveal differences in the dynamic behavior of the S1' binding pocket Curr Pharm Des (2007) 13, 3471-3475. PubMed Europe PubMed DOI I
Diaz,N. and Suarez,D. Molecular dynamics simulations of matrix metalloproteinase 2: role of the structural metal ions Biochemistry (2007) 46, 8943-8952. PubMed Europe PubMed DOI
Egeblad,M., Shen,H.C., Behonick,D.J., Wilmes,L., Eichten,A., Korets,L.V., Kheradmand,F., Werb,Z. and Coussens,L.M. Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development Dev Dyn (2007) 236, 1683-1693. PubMed Europe PubMed DOI PMC EPMC K M
Gioia,M., Monaco,S., Fasciglione,G.F., Coletti,A., Modesti,A., Marini,S. and Coletta,M. Characterization of the mechanisms by which gelatinase A, neutrophil collagenase, and membrane-type metalloproteinase MMP-14 recognize collagen I and enzymatically process the two alpha-chains J Mol Biol (2007) 368, 1101-1113. PubMed Europe PubMed DOI
Hanaoka,H., Mukai,T., Habashita,S., Asano,D., Ogawa,K., Kuroda,Y., Akizawa,H., Iida,Y., Endo,K., Saga,T. and Saji,H. Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors Nucl Med Biol (2007) 34, 503-510. PubMed Europe PubMed DOI L I
Hasebe,T., Hartman,R., Fu,L., Amano,T. and Shi,Y.B. Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development Mech Dev (2007) 124, 11-22. PubMed Europe PubMed DOI PMC EPMC
Hayashi,R., Jin,X. and Cook,G.R. Synthesis and evaluation of novel heterocyclic MMP inhibitors Bioorg Med Chem Lett (2007) 17, 6864-6870. PubMed Europe PubMed DOI PMC EPMC I
Iida,J., Wilhelmson,K.L., Ng,J., Lee,P., Morrison,C., Tam,E., Overall,C.M. and McCarthy,J.B. Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A) Biochem J (2007) 403, 553-563. PubMed Europe PubMed DOI PMC EPMC
Lauer-Fields,J., Brew,K., Whitehead,J.K., Li,S., Hammer,R.P. and Fields,G.B. Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors J Am Chem Soc (2007) 129, 10408-10417. PubMed Europe PubMed DOI PMC EPMC I
Lee,M., Villegas-Estrada,A., Celenza,G., Boggess,B., Toth,M., Kreitinger,G., Forbes,C., Fridman,R., Mobashery,S. and Chang,M. Metabolism of a highly selective gelatinase inhibitor generates active metabolite Chem Biol Drug Des (2007) 70, 371-382. PubMed Europe PubMed DOI I
Monaco,S., Gioia,M., Rodriguez,J., Fasciglione,G.F., Di Pierro,D., Lupidi,G., Krippahl,L., Marini,S. and Coletta,M. Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen Biochem J (2007) 402, 503-513. PubMed Europe PubMed DOI PMC EPMC
Mosig,R.A., Dowling,O., DiFeo,A., Ramirez,M.C., Parker,I.C., Abe,E., Diouri,J., Aqeel,A.A., Wylie,J.D., Oblander,S.A., Madri,J., Bianco,P., Apte,S.S., Zaidi,M., Doty,S.B., Majeska,R.J., Schaffler,M.B. and Martignetti,J.A. Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth Hum Mol Genet (2007) 16, 1113-1123. PubMed Europe PubMed DOI PMC EPMC K M
Taniwaki,K., Fukamachi,H., Komori,K., Ohtake,Y., Nonaka,T., Sakamoto,T., Shiomi,T., Okada,Y., Itoh,T., Itohara,S., Seiki,M. and Yana,I. Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice Cancer Res (2007) 67, 4311-4319. PubMed Europe PubMed DOI
Tsukamoto,H., Yokoyama,Y., Suzuki,T., Mizuta,S. and Yoshinaka,R. Molecular cloning and expression of gelatinases (MMP-2 and MMP-9) in the pufferfish Takifugu rubripes Comp Biochem Physiol B Biochem Mol Biol (2007) 148, 295-302. PubMed Europe PubMed DOI

2006

[YEAR:30-10-2006]Bellosta,S., Gomaraschi,M., Canavesi,M., Rossoni,G., Monetti,M., Franceschini,G. and Calabresi,L. Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection FEBS Lett (30-10-2006) 580, 5974-5978. PubMed Europe PubMed DOI T
[YEAR:4-8-2006]Cheng,S., Pollock,A.S., Mahimkar,R., Olson,J.L. and Lovett,D.H. Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury FASEB J (4-8-2006) 20, 1898-1900. PubMed Europe PubMed DOI T
Greenlee,K.J., Corry,D.B., Engler,D.A., Matsunami,R.K., Tessier,P., Cook,R.G., Werb,Z. and Kheradmand,F. Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation J Immunol (2006) 177, 7312-7321. PubMed Europe PubMed PMC EPMC
[YEAR:18-1-2006]Hasebe,T., Hartman,R., Matsuda,H. and Shi,Y.B. Spatial and temporal expression profiles suggest the involvement of gelatinase A and membrane type 1 matrix metalloproteinase in amphibian metamorphosis Cell Tissue Res (18-1-2006) 324, 105-116. PubMed Europe PubMed DOI
[YEAR:27-2-2006]Matsusaka,H., Ide,T., Matsushima,S., Ikeuchi,M., Kubota,T., Sunagawa,K., Kinugawa,S. and Tsutsui,H. Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload Hypertension (27-2-2006) 47, 711-717. PubMed Europe PubMed DOI K
Monaco,S., Sparano,V., Gioia,M., Sbardella,D., Di Pierro,D., Marini,S. and Coletta,M. Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains Protein Sci (2006) 15, 2805-2815. PubMed Europe PubMed DOI PMC EPMC
[YEAR:28-9-2006]Nakaji,K., Ihara,M., Takahashi,C., Itohara,S., Noda,M., Takahashi,R. and Tomimoto,H. Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents Stroke (28-9-2006) 37, 2816-2823. PubMed Europe PubMed DOI T I
Thompson,M. and Cockerill,G. Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis Ann N Y Acad Sci (2006) 1085, 170-174. PubMed Europe PubMed DOI
[YEAR:14-2-2006]Tuccinardi,T., Martinelli,A., Nuti,E., Carelli,P., Balzano,F., Uccello-Barretta,G., Murphy,G. and Rossello,A. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides Bioorg Med Chem (14-2-2006) 14, 4260-4276. PubMed Europe PubMed DOI I
[YEAR:7-6-2006]Yamamoto,S., Nakatani,S., Ikura,M., Sugiura,T., Nishita,Y., Itadani,S., Ogawa,K., Ohno,H., Takahashi,K., Nakai,H. and Toda,M. Design and synthesis of an orally active matrix metalloproteinase inhibitor Bioorg Med Chem (7-6-2006) 14, 6383-6403. PubMed Europe PubMed DOI I
[YEAR:26-9-2006]Zhang,L., Zhang,J., Fang,H., Wang,Q. and Xu,W. Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors Bioorg Med Chem (26-9-2006) 14, 8286-8294. PubMed Europe PubMed DOI I

2005

Agamennone,M., Campestre,C., Preziuso,S., Consalvi,V., Crucianelli,M., Mazza,F., Politi,V., Ragno,R., Tortorella,P. and Gallina,C. Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2 Eur J Med Chem (2005) 40, 271-279. PubMed Europe PubMed DOI I
Al-Aqeel,A.I. Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene Saudi Med J (2005) 26, 24-30. PubMed Europe PubMed M
Ben-Yosef,Y., Miller,A., Shapiro,S. and Lahat,N. Hypoxia of endothelial cells leads to MMP-2-dependent survival and death Am J Physiol Cell Physiol (2005) 289, C1321-C1331. PubMed Europe PubMed DOI
[YEAR:31-5-2005]Bianchini,G., Aschi,M., Cavicchio,G., Crucianelli,M., Preziuso,S., Gallina,C., Nastari,A., Gavuzzo,E. and Mazza,F. Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8 Bioorg Med Chem (31-5-2005) 13, 4740-4749. PubMed Europe PubMed DOI I
[YEAR:6-1-2005]Cao,J., Rehemtulla,A., Pavlaki,M., Kozarekar,P. and Chiarelli,C. Furin directly cleaves proMMP-2 in the trans-golgi network resulting in a nonfunctioning proteinase J Biol Chem (6-1-2005) 280, 10974-10980. PubMed Europe PubMed DOI
[YEAR:29-9-2005]Lee,M., Bernardo,M.M., Meroueh,S.O., Brown,S., Fridman,R. and Mobashery,S. Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors Org Lett (29-9-2005) 7, 4463-4465. PubMed Europe PubMed DOI I
[YEAR:22-7-2005]Lindstad,R.I., Sylte,I., Mikalsen,S.O., Seglen,P.O., Berg,E. and Winberg,J.O. Pancreatic trypsin activates human promatrix metalloproteinase-2 J Mol Biol (22-7-2005) 350, 682-698. PubMed Europe PubMed DOI
[YEAR:3-6-2005]Matsusaka,H., Ikeuchi,M., Matsushima,S., Ide,T., Kubota,T., Feldman,A.M., Takeshita,A., Sunagawa,K. and Tsutsui,H. Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy Am J Physiol Heart Circ Physiol (3-6-2005) 289, H1858-H1864. PubMed Europe PubMed DOI
Oblander,S.A., Zhou,Z., Galvez,B.G., Starcher,B., Shannon,J.M., Durbeej,M., Arroyo,A.G., Tryggvason,K. and Apte,S.S. Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation Dev Biol (2005) 277, 255-269. PubMed Europe PubMed DOI
[YEAR:1-3-2005]Rossello,A., Nuti,E., Carelli,P., Orlandini,E., Macchia,M., Nencetti,S., Zandomeneghi,M., Balzano,F., Uccello Barretta,G., Albini,A., Benelli,R., Cercignani,G., Murphy,G. and Balsamo,A. N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP Bioorg Med Chem Lett (1-3-2005) 15, 1321-1326. PubMed Europe PubMed DOI I
[YEAR:26-7-2005]Sawicki,G., Leon,H., Sawicka,J., Sariahmetoglu,M., Schulze,C.J., Scott,P.G., Szczesna-Cordary,D. and Schulz,R. Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2 Circulation (26-7-2005) 112, 544-552. PubMed Europe PubMed DOI
[YEAR:10-3-2005]Wang,F.Q., So,J., Reierstad,S. and Fishman,D.A. Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase Int J Cancer (10-3-2005) 114, 19-31. PubMed Europe PubMed DOI
[YEAR:12-7-2005]Xu,X., Chen,Z., Wang,Y., Yamada,Y. and Steffensen,B. Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2 Biochem J (12-7-2005) 392, 127-134. PubMed Europe PubMed DOI PMC EPMC
Zankl,A., Bonafe,L., Calcaterra,V., Di Rocco,M. and Superti-Furga,A. Winchester syndrome caused by a homozygous mutation affecting the active site of matrix metalloproteinase 2 Clin Genet (2005) 67, 261-266. PubMed Europe PubMed DOI M

2004

[YEAR:21-9-2004]Belkin,A.M., Zemskov,E.A., Hang,J., Akimov,S.S., Sikora,S. and Strongin,A.Y. Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis Biochemistry (21-9-2004) 43, 11760-11769. PubMed Europe PubMed DOI
[YEAR:19-1-2004]Butler,G.S., Tam,E.M. and Overall,C.M. The canonical methionine 392 of matrix metalloproteinase 2 (gelatinase A) is not required for catalytic efficiency or structural integrity: probing the role of the methionine-turn in the metzincin metalloprotease superfamily J Biol Chem (19-1-2004) 279, 15615-15620. PubMed Europe PubMed DOI I
Duong,T.D. and Erickson,C.A. MMP-2 plays an essential role in producing epithelial-mesenchymal transformations in the avian embryo Dev Dyn (2004) 229, 42-53. PubMed Europe PubMed DOI
Grieu,F., Li,W.Q. and Iacopetta,B. Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype Breast Cancer Res Treat (2004) 88, 197-204. PubMed Europe PubMed DOI M
[YEAR:6-2-2004]Kwan,J.A., Schulze,C.J., Wang,W., Leon,H., Sariahmetoglu,M., Sung,M., Sawicka,J., Sims,D.E., Sawicki,G. and Schulz,R. Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro FASEB J (6-2-2004) 18, 690-692. PubMed Europe PubMed DOI
[YEAR:17-8-2004]Ma,Z., Chang,M.J., Shah,R., Adamski,J., Zhao,X. and Benveniste,E.N. Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene J Biol Chem (17-8-2004) 279, 46326-46334. PubMed Europe PubMed DOI
[YEAR:1-11-2004]Martinez,A., Oh,H.R., Unsworth,E.J., Bregonzio,C., Saavedra,J.M., Stetler-Stevenson,W.G. and Cuttitta,F. Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator Biochem J (1-11-2004) 383, 413-418. PubMed Europe PubMed DOI PMC EPMC
Murphy,G. Gelatinase A [ISSN:0-12-079610-4] (2004) 2, 497-503. V
[YEAR:28-9-2004]Oak,M.H., El Bedoui,J., Anglard,P. and Schini-Kerth,V.B. Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells Circulation (28-9-2004) 110, 1861-1867. PubMed Europe PubMed DOI
[YEAR:5-4-2004]Oh,J., Takahashi,R., Adachi,E., Kondo,S., Kuratomi,S., Noma,A., Alexander,D.B., Motoda,H., Okada,A., Seiki,M., Itoh,T., Itohara,S., Takahashi,C. and Noda,M. Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice Oncogene (5-4-2004) 23, 5041-5048. PubMed Europe PubMed DOI K
[YEAR:1-5-2004]Rossello,A., Nuti,E., Orlandini,E., Carelli,P., Rapposelli,S., Macchia,M., Minutolo,F., Carbonaro,L., Albini,A., Benelli,R., Cercignani,G., Murphy,G. and Balsamo,A. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) Bioorg Med Chem (1-5-2004) 12, 2441-2450. PubMed Europe PubMed DOI I
Svab,I., Alexandru,D., Vitos,G. and Flonta,M.L. Binding affinities for sulfonamide inhibitors with matrix metalloproteinase-2 using a linear response method J Cell Mol Med (2004) 8, 551-562. PubMed Europe PubMed I
[YEAR:19-11-2004]Xu,E., Lai,M., Lv,B., Xing,X., Huang,Q. and Xia,X. A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer Biochem Biophys Res Commun (19-11-2004) 324, 999-1003. PubMed Europe PubMed DOI M
[YEAR:21-2-2004]Zhang,W., Hou,T.J., Qiao,X.B., Huai,S. and Xu,X.J. Binding affinity of hydroxamate inhibitors of matrix metalloproteinase-2 J Mol Model (21-2-2004) 10, 112-120. PubMed Europe PubMed DOI I
[YEAR:16-12-2004]Zhao,H., Bernardo,M.M., Osenkowski,P., Sohail,A., Pei,D., Nagase,H., Kashiwagi,M., Soloway,P.D., DeClerck,Y.A. and Fridman,R. Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation J Biol Chem (16-12-2004) 279, 8592-8601. PubMed Europe PubMed DOI I

2003

[YEAR:19-5-2003]Auge,F., Hornebeck,W., Decarme,M. and Laronze,J.Y. Improved gelatinase A selectivity by novel zinc binding groups containing galardin derivatives Bioorg Med Chem Lett (19-5-2003) 13, 1783-1786. PubMed Europe PubMed DOI I
Chen,E.I., Li,W., Godzik,A., Howard,E.W. and Smith,J.W. A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9 J Biol Chem (2003) 278, 17158-17163. PubMed Europe PubMed DOI
Cheng,D., Shen,Q., Nan,F., Qian,Z. and Ye,Q.Z. Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for high-throughput inhibitor screening Protein Expr Purif (2003) 27, 63-74. PubMed Europe PubMed DOI I
Cheng,S. and Lovett,D.H. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation Am J Pathol (2003) 162, 1937-1949. PubMed Europe PubMed DOI PMC EPMC
[YEAR:7-2-2003]Deshane,J., Garner,C.C. and Sontheimer,H. Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2 J Biol Chem (7-2-2003) 278, 4135-4144. PubMed Europe PubMed DOI
[YEAR:6-6-2003]Harendza,S., Lovett,D.H., Panzer,U., Lukacs,Z., Kuhnl,P. and Stahl,R.A. Linked common polymorphisms in the gelatinase A promoter are associated with diminished transcriptional response to estrogen and genetic fitness J Biol Chem (6-6-2003) 278, 20490-20499. PubMed Europe PubMed DOI M
Hayashidani,S., Tsutsui,H., Ikeuchi,M., Shiomi,T., Matsusaka,H., Kubota,T., Imanaka-Yoshida,K., Itoh,T. and Takeshita,A. Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction Am J Physiol Heart Circ Physiol (2003) 285, H1229-H1235. PubMed Europe PubMed DOI
[YEAR:3-6-2003]Higashi,S. and Miyazaki,K. Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase A Biochemistry (3-6-2003) 42, 6514-6526. PubMed Europe PubMed DOI
[YEAR:18-4-2003]Higashi,S. and Miyazaki,K. Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity J Biol Chem (18-4-2003) 278, 14020-14028. PubMed Europe PubMed DOI
[YEAR:23-10-2003]Lafleur,M.A., Tester,A.M. and Thompson,E.W. Selective involvement of TIMP-2 in the second activational cleavage of pro-MMP-2: refinement of the pro-MMP-2 activation mechanism FEBS Lett (23-10-2003) 553, 457-463. PubMed Europe PubMed DOI
Lauer-Fields,J.L., Sritharan,T., Stack,M.S., Nagase,H. and Fields,G.B. Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9 J Biol Chem (2003) 278, 18140-18145. PubMed Europe PubMed DOI
[YEAR:15-7-2003]Miao,X., Yu,C., Tan,W., Xiong,P., Liang,G., Lu,W. and Lin,D. A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma Cancer Res (15-7-2003) 63, 3987-3990. PubMed Europe PubMed M
Ohno-Matsui,K., Uetama,T., Yoshida,T., Hayano,M., Itoh,T., Morita,I. and Mochizuki,M. Reduced retinal angiogenesis in MMP-2-deficient mice Invest Ophthalmol Vis Sci (2003) 44, 5370-5375. PubMed Europe PubMed DOI K
[YEAR:18-7-2003]Rosenblum,G., Meroueh,S.O., Kleifeld,O., Brown,S., Singson,S.P., Fridman,R., Mobashery,S. and Sagi,I. Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2) J Biol Chem (18-7-2003) 278, 27009-27015. PubMed Europe PubMed DOI
[YEAR:4-4-2003]Trexler,M., Briknarova,K., Gehrmann,M., Llinas,M. and Patthy,L. Peptide ligands for the fibronectin type II modules of matrix metalloproteinase 2 (MMP-2) J Biol Chem (4-4-2003) 278, 12241-12246. PubMed Europe PubMed DOI
Vasku,A., Goldbergova,M., Holla,L.I., Spinarova,L., Spinar,J., Vitovec,J. and Vacha,J. Two MMP-2 promoter polymorphisms (-790T/G and -735C/T) in chronic heart failure Clin Chem Lab Med (2003) 41, 1299-1303. PubMed Europe PubMed DOI M
Zhang,K., McQuibban,G.A., Silva,C., Butler,G.S., Johnston,J.B., Holden,J., Clark-Lewis,I., Overall,C.M. and Power,C. HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration Nat Neurosci (2003) 6, 1064-1071. PubMed Europe PubMed DOI

2002

[YEAR:3-5-2002]Bannikov,G.A., Karelina,T.V., Collier,I.E., Marmer,B.L. and Goldberg,G.I. Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide J Biol Chem (3-5-2002) 277, 16022-16027. PubMed Europe PubMed DOI
[YEAR:8-2-2002]Chen,E.I., Kridel,S.J., Howard,E.W., Li,W., Godzik,A. and Smith,J.W. A unique substrate recognition profile for matrix metalloproteinase-2 J Biol Chem (8-2-2002) 277, 4485-4491. PubMed Europe PubMed DOI
[YEAR:29-7-2002]Feng,Y., Likos,J.J., Zhu,L., Woodward,H., Munie,G., McDonald,J.J., Stevens,A.M., Howard,C.P., De Crescenzo,G.A., Welsch,D., Shieh,H.S. and Stallings,W.C. Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor Biochim Biophys Acta (29-7-2002) 1598, 10-23. PubMed Europe PubMed S I
Gehrmann,M., Briknarova,K., Banyai,L., Patthy,L. and Llinas,M. The col-1 module of human matrix metalloproteinase-2 (MMP-2): Structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains Biol Chem (2002) 383, 137-148. PubMed Europe PubMed DOI
Longo,G.M., Xiong,W., Greiner,T.C., Zhao,Y., Fiotti,N. and Baxter,B.T. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms J Clin Invest (2002) 110, 625-632. PubMed Europe PubMed DOI PMC EPMC
[YEAR:28-5-2002]Morgunova,E., Tuuttila,A., Bergmann,U. and Tryggvason,K. Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2 Proc Natl Acad Sci U S A (28-5-2002) 99, 7414-7419. PubMed Europe PubMed DOI PMC EPMC S

2001

Sulfone reverse hydroxamates as matrix metalloproteinase inhibitors Expert Opin Ther Pat (2001) 11, 133-143. DOI V I
[YEAR:2-3-2001]Atkinson,S.J., Patterson,M.L., Butler,M.J. and Murphy,G. Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model FEBS Lett (2-3-2001) 491, 222-226. PubMed Europe PubMed DOI
[YEAR:8-6-2001]Berton,A., Rigot,V., Huet,E., Decarme,M., Eeckhout,Y., Patthy,L., Godeau,G., Hornebeck,W., Bellon,G. and Emonard,H. Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids J Biol Chem (8-6-2001) 276, 20458-20465. PubMed Europe PubMed DOI I
[YEAR:20-7-2001]Briknarova,K., Gehrmann,M., Banyai,L., Tordai,H., Patthy,L. and Llinas,M. Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct J Biol Chem (20-7-2001) 276, 27613-27621. PubMed Europe PubMed DOI
Chen,J.M., Fortunato,M., Stevens,R.A.E. and Barrett,A.J. Activation of progelatinase A by mammalian legumain, a recently discovered cysteine proteinase Biol Chem (2001) 382, 777-783. PubMed Europe PubMed DOI
[YEAR:15-2-2001]Deryugina,E.I., Ratnikov,B., Monosov,E., Postnova,T.I., DiScipio,R., Smith,J.W. and Strongin,A.Y. MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells Exp Cell Res (15-2-2001) 263, 209-223. PubMed Europe PubMed DOI
Fray,M.J., Burslem,M.F. and Dickinson,R.P. Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality Bioorg Med Chem Lett (2001) 11, 567-570. PubMed Europe PubMed DOI I
Han,Y.P., Tuan,T.L., Wu,H., Hughes,M. and Garner,W.L. TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP J Cell Sci (2001) 114, 131-139. PubMed Europe PubMed PMC EPMC
Ihara,M., Tomimoto,H., Kinoshita,M., Oh,J., Noda,M., Wakita,H., Akiguchi,I. and Shibasaki,H. Chronic cerebral hypoperfusion induces MMP-2 but not MMP-9 expression in the microglia and vascular endothelium of white matter J Cereb Blood Flow Metab (2001) 21, 828-834. PubMed Europe PubMed DOI
[YEAR:3-9-2001]Itoh,Y., Takamura,A., Ito,N., Maru,Y., Sato,H., Suenaga,N., Aoki,T. and Seiki,M. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion EMBO J (3-9-2001) 20, 4782-4793. PubMed Europe PubMed DOI PMC EPMC
Jackson,C., Nguyen,M., Arkell,J. and Sambrook,P. Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - Targetting gelatinase A activation Inflamm Res (2001) 50, 183-186. PubMed Europe PubMed DOI
[YEAR:18-5-2001]Kleifeld,O., Kotra,L.P., Gervasi,D.C., Brown,S., Bernardo,M.M., Fridman,R., Mobashery,S. and Sagi,I. X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. Comparison with the latent and active forms of the enzyme J Biol Chem (18-5-2001) 276, 17125-17131. PubMed Europe PubMed DOI S I
Kraft,P.J., Haynes-Johnson,D.E., Patel,L., Lenhart,J.A., Zivin,R.A. and Palmer,S.S. Fluorescence polarization assay and SDS-PAGE confirms matrilysin degrades fibronectin and collagen IV whereas gelatinase a degrades collagen IV but not fibronectin Connect Tissue Res (2001) 42, 149-163. PubMed Europe PubMed
[YEAR:1-7-2001]Lafleur,M.A., Hollenberg,M.D., Atkinson,S.J., Knauper,V., Murphy,G. and Edwards,D.R. Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species Biochem J (1-7-2001) 357, 107-115. PubMed Europe PubMed DOI PMC EPMC
Lijnen,H.R., Maquoi,E., Holvoet,P., Mertens,A., Lupu,F., Morange,P., Alessi,M.C. and Juhan-Vague,I. Adipose tissue expression of gelatinases in mouse models of obesity Thromb Haemost (2001) 85, 1111-1116. PubMed Europe PubMed
Martignetti,J.A., Aqeel,A.A., Sewairi,W.A., Boumah,C.E., Kambouris,M., Mayouf,S.A., Sheth,K.V., Eid,W.A., Dowling,O., Harris,J., Glucksman,M.J., Bahabri,S., Meyer,B.F. and Desnick,R.J. Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome Nat Genet (2001) 28, 261-265. PubMed Europe PubMed DOI
[YEAR:15-5-2001]Medina,O.P., Soderlund,T., Laakkonen,L.J., Tuominen,E.K., Koivunen,E. and Kinnunen,P.K. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro Cancer Res (15-5-2001) 61, 3978-3985. PubMed Europe PubMed I
[YEAR:14-12-2001]Morrison,C.J., Butler,G.S., Bigg,H.F., Roberts,C.R., Soloway,P.D. and Overall,C.M. Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway J Biol Chem (14-12-2001) 276, 47402-47410. PubMed Europe PubMed DOI
Natchus,M.G., Bookland,R.G., Laufersweiler,M.J., Pikul,S., Almstead,N.G., De,B., Janusz,M.J., Hsieh,L.C., Gu,F., Pokross,M.E., Patel,V.S., Garver,S.M., Peng,S.X., Branch,T.M., King,S.L., Baker,T.R., Foltz,D.J. and Mieling,G.E. Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines J Med Chem (2001) 44, 1060-1071. PubMed Europe PubMed DOI I
[YEAR:17-8-2001]Patterson,M.L., Atkinson,S.J., Knauper,V. and Murphy,G. Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain FEBS Lett (17-8-2001) 503, 158-162. PubMed Europe PubMed DOI
[YEAR:6-4-2001]Pekovich,S.R., Bock,P.E. and Hoover,R.L. Thrombin-thrombomodulin activation of protein C facilitates the activation of progelatinase A FEBS Lett (6-4-2001) 494, 129-132. PubMed Europe PubMed DOI
[YEAR:9-3-2001]Price,S.J., Greaves,D.R. and Watkins,H. Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation J Biol Chem (9-3-2001) 276, 7549-7558. PubMed Europe PubMed DOI M
[YEAR:1-1-2001]Puyraimond,A., Fridman,R., Lemesle,M., Arbeille,B. and Menashi,S. MMP-2 colocalizes with caveolae on the surface of endothelial cells Exp Cell Res (1-1-2001) 262, 28-36. PubMed Europe PubMed DOI
Ruangpanit,N., Chan,D., Holmbeck,K., Birkedal-Hansen,H., Polarek,J., Yang,C., Bateman,J.F. and Thompson,E.W. Gelatinase A (MMP-2) activation by skin fibroblasts: dependence on MT1-MMP expression and fibrillar collagen form Matrix Biol (2001) 20, 193-203. PubMed Europe PubMed DOI
Shamamian,P., Schwartz,J.D., Pocock,B.J., Monea,S., Whiting,D., Marcus,S.G. and Mignatti,P. Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: A role for inflammatory cells in tumor invasion and angiogenesis J Cell Physiol (2001) 189, 197-206. PubMed Europe PubMed DOI
[YEAR:16-3-2001]Yang,Z., Strickland,D.K. and Bornstein,P. Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2 J Biol Chem (16-3-2001) 276, 8403-8408. PubMed Europe PubMed DOI

2000

[YEAR:25-8-2000]Caterina,J.J., Yamada,S., Caterina,N.C., Longenecker,G., Holmback,K., Shi,J., Yermovsky,A.E., Engler,J.A. and Birkedal-Hansen,H. Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2 (Timp-2) gene alters proMMP-2 activation J Biol Chem (25-8-2000) 275, 26416-26422. PubMed Europe PubMed DOI
Fasciglione,G.F., Marini,S., D'Alessio,S., Politi,V. and Coletta,M. pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B Biophys J (2000) 79, 2138-2149. PubMed Europe PubMed DOI PMC EPMC
[YEAR:20-9-2000]Gingras,D., Page,M., Annabi,B. and Beliveau,R. Rapid activation of matrix metalloproteinase-2 by glioma cells occurs through a posttranslational MT1-MMP-dependent mechanism Biochim Biophys Acta (20-9-2000) 1497, 341-350. PubMed Europe PubMed DOI
[YEAR:18-8-2000]McQuibban,G.A., Gong,J.H., Tam,E.M., McCulloch,C.A., Clark-Lewis,I. and Overall,C.M. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3 Science (18-8-2000) 289, 1202-1206. PubMed Europe PubMed DOI
[YEAR:15-12-2000]Overall,C.M., Tam,E., McQuibban,G.A., Morrison,C., Wallon,U.M., Bigg,H.F., King,A.E. and Roberts,C.R. Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation J Biol Chem (15-12-2000) 275, 39497-39506. PubMed Europe PubMed DOI

1999

[YEAR:15-10-1999]Briknarova,K., Grishaev,A., Banyai,L., Tordai,H., Patthy,L. and Llinas,M. The second type II module from human matrix metalloproteinase 2: structure, function and dynamics Structure (15-10-1999) 7, 1235-1245. PubMed Europe PubMed DOI
[YEAR:16-4-1999]Butler,G.S., Apte,S.S., Willenbrock,F. and Murphy,G. Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions J Biol Chem (16-4-1999) 274, 10846-10851. PubMed Europe PubMed DOI
[YEAR:12-11-1999]Fernandez-Patron,C., Radomski,M.W. and Davidge,S.T. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor Circ Res (12-11-1999) 85, 906-911. PubMed Europe PubMed
[YEAR:25-8-1999]Makela,M., Larjava,H., Pirila,E., Maisi,P., Salo,T., Sorsa,T. and Uitto,V.J. Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes Exp Cell Res (25-8-1999) 251, 67-78. PubMed Europe PubMed DOI I
[YEAR:4-6-1999]Morgunova,E., Tuuttila,A., Bergmann,U., Isupov,M., Lindqvist,Y., Schneider,G. and Tryggvason,K. Structure of human pro-matrix metalloproteinase-2: Activation mechanism revealed Science (4-6-1999) 284, 1667-1670. PubMed Europe PubMed DOI S
Nguyen,M., Arkell,J. and Jackson,C.J. Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells via a mechanism independent of active MT1 matrix metalloproteinase Lab Invest (1999) 79, 467-475. PubMed Europe PubMed
[YEAR:12-2-1999]Overall,C.M., King,A.E., Sam,D.K., Ong,A.D., Lau,T.T., Wallon,U.M., DeClerck,Y.A. and Atherstone,J. Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site-directed mutagenesis. The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV J Biol Chem (12-2-1999) 274, 4421-4429. PubMed Europe PubMed DOI
[YEAR:30-7-1999]Passi,A., Negrini,D., Albertini,R., Miserocchi,G. and De Luca,G. The sensitivity of versican from rabbit lung to gelatinase A (MMP-2) and B (MMP-9) and its involvement in the development of hydraulic lung edema FEBS Lett (30-7-1999) 456, 93-96. PubMed Europe PubMed DOI

1998

[YEAR:9-1-1998]Butler,G.S., Butler,M.J., Atkinson,S.J., Will,H., Tamura,T., Schade van Westrum,S., Crabbe,T., Clements,J., d'Ortho,M.P. and Murphy,G. The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study J Biol Chem (9-1-1998) 273, 871-880. PubMed Europe PubMed DOI
[YEAR:15-7-1998]Farina,A.R., Tacconelli,A., Teti,A., Gulino,A. and Mackay,A.R. Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate Cancer Res (15-7-1998) 58, 2957-2960. PubMed Europe PubMed
[YEAR:19-6-1998]Ferry,G., Boutin,J.A., Hennig,P., Genton,A., Desmet,C., Fauchere,J.L., Atassi,G. and Tucker,G.C. A zinc chelator inhibiting gelatinases exerts potent in vitro anti-invasive effects Eur J Pharmacol (19-6-1998) 351, 225-233. PubMed Europe PubMed DOI I
Hayashi,K., Osada,S., Shofuda,K., Horikoshi,S., Shirato,I. and Tomino,Y. Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis J Am Soc Nephrol (1998) 9, 2262-2271. PubMed Europe PubMed
[YEAR:14-7-1998]Hutton,M., Willenbrock,F., Brocklehurst,K. and Murphy,G. Kinetic analysis of the mechanism of interaction of full-length TIMP-2 and gelatinase A: Evidence for the existence of a low-affinity intermediate Biochemistry (14-7-1998) 37, 10094-10098. PubMed Europe PubMed DOI
[YEAR:1-3-1998]Itoh,T., Tanioka,M., Yoshida,H., Yoshioka,T., Nishimoto,H. and Itohara,S. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice Cancer Res (1-3-1998) 58, 1048-1051. PubMed Europe PubMed
[YEAR:18-9-1998]Itoh,Y., Ito,A., Iwata,K., Tanzawa,K., Mori,Y. and Nagase,H. Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface J Biol Chem (18-9-1998) 273, 24360-24367. PubMed Europe PubMed DOI
[YEAR:26-6-1998]Kinoshita,T., Sato,H., Okada,A., Ohuchi,E., Imai,K., Okada,Y. and Seiki,M. TIMP-2 promotes activation of progelatinase a by membrane-type 1 matrix metalloproteinase immobilized on agarose beads J Biol Chem (26-6-1998) 273, 16098-16103. PubMed Europe PubMed DOI
[YEAR:1-9-1998]Lehti,K., Lohi,J., Valtanen,H. and Keski-Oja,J. Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface Biochem J (1-9-1998) 334, 345-353. PubMed Europe PubMed PMC EPMC
Lijnen,H.R., Silence,J., Lemmens,G., Frederix,L. and Collen,D. Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system Thromb Haemost (1998) 79, 1171-1176. PubMed Europe PubMed
[YEAR:13-3-1998]Maquoi,E., Noel,A., Frankenne,F., Angliker,H., Murphy,G. and Foidart,J.M. Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor FEBS Lett (13-3-1998) 424, 262-266. PubMed Europe PubMed DOI I
Xuan,J.W., Tuck,A.B., Wilson,S.M., Chin,J.L. and Chambers,A.F. MMP-2 expression is associated with, but not sufficient for, malignant conversion of murine LTA cells Anticancer Res (1998) 18, 743-749. PubMed Europe PubMed

1997

Bigg,H.F., Shi,Y.E., Liu,Y.E., Steffensen,B. and Overall,C.M. Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2 J Biol Chem (1997) 272, 15496-15500. PubMed Europe PubMed DOI
Burns,E.H., Jr., Marciel,A.M. and Musser,J.M. Structure-function and pathogenesis studies of Streptococcus pyogenes extracellular cysteine protease Adv Exp Med Biol (1997) 418, 589-592. PubMed Europe PubMed
Deryugina,E.I., Luo,G.X., Reisfeld,R.A., Bourdon,M.A. and Strongin,A. Tumor cell invasion through Matrigel is regulated by activated matrix metalloproteinase-2 Anticancer Res (1997) 17, 3201-3210. PubMed Europe PubMed
Kolkenbrock,H., Hecker-Kia,A., Orgel,D., Ulbrich,N. and Will,H. Activation of progelatinase A and progelatinase A/TIMP-2 complex by membrane type 2-matrix metalloproteinase Biol Chem (1997) 378, 71-76. PubMed Europe PubMed
Okada,A., Tomasetto,C., Lutz,Y., Bellocq,J.P., Rio,M.C. and Basset,P. Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A J Cell Biol (1997) 137, 67-77. PubMed Europe PubMed DOI PMC EPMC
Quesada,A.R., Barbacid,M.M., Mira,E., Fernandez-Resa,P., Marquez,G. and Aracil,M. Evaluation of fluorometric and zymographic methods as activity assays for stromelysins and gelatinases Clin Exp Metastasis (1997) 15, 26-32. PubMed Europe PubMed DOI A
Ueno,H., Nakamura,H., Inoue,M., Imai,K., Noguchi,M., Sato,H., Seiki,M. and Okada,Y. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas Cancer Res (1997) 57, 2055-2060. PubMed Europe PubMed

1996

[YEAR:31-5-1996]Brooks,P.C., Stromblad,S., Sanders,L.C., von Schalscha,T.L., Aimes,R.T., Stetler-Stevenson,W.G., Quigley,J.P. and Cheresh,D.A. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 Cell (31-5-1996) 85, 683-693. PubMed Europe PubMed DOI
Fishman,D.A., Bafetti,L.M. and Stack,M.S. Membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation in primary human ovarian epithelial carcinoma cells Invasion Metastasis (1996) 16, 150-159. PubMed Europe PubMed
Gohlke,U., Gomis-Ruth,F.X., Crabbe,T., Murphy,G., Docherty,A.J. and Bode,W. The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function FEBS Lett (1996) 378, 126-130. PubMed Europe PubMed DOI

1995

Atkinson,S.J., Crabbe,T., Cowell,S., Ward,R.V., Butler,M.J., Sato,H., Seiki,M., Reynolds,J.J. and Murphy,G. Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes J Biol Chem (1995) 270, 30479-30485. PubMed Europe PubMed DOI
Chander,S.K., Antoniw,P., Beeley,N.R., Boyce,B., Crabbe,T., Docherty,A.J., Leonard,J., Mason,B., Millar,K. and Millican,A.T. An in vivo model for screening peptidomimetic inhibitors of gelatinase A J Pharm Sci (1995) 84, 404-409. PubMed Europe PubMed DOI I
[YEAR:15-6-1995]Fridman,R., Toth,M., Pena,D. and Mobashery,S. Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2) Cancer Res (15-6-1995) 55, 2548-2555. PubMed Europe PubMed
[YEAR:1-6-1995]Itoh,Y., Binner,S. and Nagase,H. Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenylmercuric acetate Biochem J (1-6-1995) 308, 645-651. PubMed Europe PubMed PMC EPMC
Libson,A.M., Gittis,A.G., Collier,I.E., Marmer,B.L., Goldberg,G.I. and Lattman,E.E. Crystal structure of the haemopexin-like C-terminal domain of gelatinase A Nat Struct Biol (1995) 2, 938-942. PubMed Europe PubMed S
Murphy,G. and Crabbe,T. Gelatinases A and B Methods Enzymol (1995) 248, 470-484. PubMed Europe PubMed DOI V

1994

Aimes,R.T., French,D.L. and Quigley,J.P. Cloning of a 72 kDa matrix metalloproteinase (gelatinase) from chicken embryo fibroblasts using gene family PCR: Expression of the gelatinase increases upon malignant transformation Biochem J (1994) 300, 729-736. PubMed Europe PubMed PMC EPMC
Brown,F.K., Brown,P.J., Bickett,D.M., Chambers,C.L., Davies,H.G., Deaton,D.N., Drewry,D., Foley,M., McElroy,A.B., Gregson,M., McGeehan,G.M., Myers,P.L., Norton,D., Salovich,J.M., Schoenen,F.J. and Ward,P. Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: modification of the P1 and P2' residues J Med Chem (1994) 37, 674-688. PubMed Europe PubMed I
Crabbe,T., Zucker,S., Cockett,M.I., Willenbrock,F., Tickle,S., O'Connell,J.P., Scothern,J.M., Murphy,G. and Docherty,A.J. Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1 Biochemistry (1994) 33, 6684-6690. PubMed Europe PubMed DOI
[YEAR:23-5-1994]Crabbe,T., Smith,B., O'Connell,J. and Docherty,A. Human progelatinase A can be activated by matrilysin FEBS Lett (23-5-1994) 345, 14-16. PubMed Europe PubMed DOI
Crabbe,T., O'Connell,J.P., Smith,B.J. and Docherty,A.J. Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A Biochemistry (1994) 33, 14419-14425. PubMed Europe PubMed
[YEAR:14-10-1994]Fowlkes,J.L., Enghild,J.J., Suzuki,K. and Nagase,H. Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures J Biol Chem (14-10-1994) 269, 25742-25746. PubMed Europe PubMed P
[YEAR:1-11-1994]Monsky,W.L., Lin,C.Y., Aoyama,A., Kelly,T., Akiyama,S.K., Mueller,S.C. and Chen,W.T. A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells Cancer Res (1-11-1994) 54, 5702-5710. PubMed Europe PubMed
Nguyen,Q., Willenbrock,F., Cockett,M.I., O'Shea,M., Docherty,A.J. and Murphy,G. Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A Biochemistry (1994) 33, 2089-2095. PubMed Europe PubMed
[YEAR:29-11-1994]Ochieng,J., Fridman,R., Nangia-Makker,P., Kleiner,D.E., Liotta,L.A., Stetler-Stevenson,W.G. and Raz,A. Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9 Biochemistry (29-11-1994) 33, 14109-14114. PubMed Europe PubMed DOI
Roher,A.E., Kasunic,T.C., Woods,A.S., Cotter,R.J., Ball,M.J. and Fridman,R. Proteolysis of Abeta peptide from Alzheimer disease brain by gelatinase A Biochem Biophys Res Commun (1994) 205, 1755-1761. PubMed Europe PubMed DOI
Sato,H., Takino,T., Okada,Y., Cao,J., Shinagawa,A., Yamamoto,E. and Seiki,M. A matrix metalloproteinase expressed on the surface of invasive tumour cells Nature (1994) 370, 61-65. PubMed Europe PubMed DOI

1993

Brown,P.D., Bloxidge,R.E., Stuart,N.S., Gatter,K.C. and Carmichael,J. Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma J Natl Cancer Inst (1993) 85, 574-578. PubMed Europe PubMed
Brown,P.D., Bloxidge,R.E., Anderson,E. and Howell,A. Expression of activated gelatinase in human invasive breast carcinoma Clin Exp Metastasis (1993) 11, 183-189. PubMed Europe PubMed
Crabbe,T., Ioannou,C. and Docherty,A.J. Human progelatinase A can be activated by autolysis at a rate that is concentration-dependent and enhanced by heparin bound to the C-terminal domain Eur J Biochem (1993) 218, 431-438. PubMed Europe PubMed DOI
Fridman,R., Bird,R.E., Hoyhtya,M., Oelkuct,M., Komarek,D., Liang,C.M., Berman,M.L., Liotta,L.A., Stetler-Stevenson,W.G. and Fuerst,T.R. Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme Biochem J (1993) 289, 411-416. PubMed Europe PubMed PMC EPMC E
Strongin,A.Y., Marmer,B.L., Grant,G.A. and Goldberg,G.I. Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP- 2 J Biol Chem (1993) 268, 14033-14039. PubMed Europe PubMed
[YEAR:27-4-1993]Willenbrock,F., Crabbe,T., Slocombe,P.M., Sutton,C.W., Docherty,A.J., Cockett,M.I., O'Shea,M., Brocklehurst,K., Phillips,I.R. and Murphy,G. The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A Biochemistry (27-4-1993) 32, 4330-4337. PubMed Europe PubMed

1992

Kleiner,D.E., Jr., Unsworth,E.J., Krutzsch,H.C. and Stetler-Stevenson,W.G. Higher-order complex formation between the 72-kilodalton type IV collagenase and tissue inhibitor of metalloproteinases- 2 Biochemistry (1992) 31, 1665-1672. PubMed Europe PubMed
Murphy,G., Willenbrock,F., Ward,R.V., Cockett,M.I., Eaton,D. and Docherty,A.J. The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases Biochem J (1992) 283, 637-641. PubMed Europe PubMed PMC EPMC
Reponen,P., Sahlberg,C., Huhtala,P., Hurskainen,T., Thesleff,I. and Tryggvason,K. Molecular cloning of murine 72-kDa type IV collagenase and its expression during mouse development J Biol Chem (1992) 267, 7856-7862. PubMed Europe PubMed

1991

Chen,J.M., Aimes,R.T., Ward,G.R., Youngleib,G.L. and Quigley,J.P. Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts J Biol Chem (1991) 266, 5113-5121. PubMed Europe PubMed
Howard,E.W. and Banda,M.J. Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site J Biol Chem (1991) 266, 17972-17977. PubMed Europe PubMed
Kolkenbrock,H., Orgel,D., Hecker-Kia,A., Noack,W. and Ulbrich,N. The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor Eur J Biochem (1991) 198, 775-781. PubMed Europe PubMed
Mast,A.E., Enghild,J.J., Nagase,H., Suzuki,K., Pizzo,S.V. and Salvesen,G. Kinetics and physiologic relevance of the inactivation of alpha1- proteinase inhibitor, alpha1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin) J Biol Chem (1991) 266, 15810-15816. PubMed Europe PubMed
Ward,R.V., Hembry,R.M., Reynolds,J.J. and Murphy,G. The purification of tissue inhibitor of metalloproteinases- 2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases- 2 and tissue inhibitor of metalloproteinases-1 Biochem J (1991) 278, 179-187. PubMed Europe PubMed PMC EPMC
Woessner,J.F., Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling FASEB J (1991) 5, 2145-2154. PubMed Europe PubMed

1990

Okada,Y., Morodomi,T., Enghild,J.J., Suzuki,K., Yasui,A., Nakanishi,I., Salvesen,G. and Nagase,H. Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties Eur J Biochem (1990) 194, 721-730. PubMed Europe PubMed

1988

Collier,I.E., Wilhelm,S.M., Eisen,A.Z., Marmer,B.L., Grant,G.A., Seltzer,J.L., Kronberger,A., He,C.S., Bauer,E.A. and Goldberg,G.I. H-ras oncogene-transformed human bronchial epithelial cells (TBE- 1) secrete a single metalloprotease capable of degrading basement membrane collagen J Biol Chem (1988) 263, 6579-6587. PubMed Europe PubMed

1985

Murphy,G., McAlpine,C.G., Poll,C.T. and Reynolds,J.J. Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen Biochim Biophys Acta (1985) 831, 49-58. PubMed Europe PubMed