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Literature for peptidase M01.029: M1 aminopeptidase (Plasmodium spp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Creek,D., Giannangelo,C., Challis,M., Siddiqui,G., Edgar,R., Malcolm,T., Webb,C., Drinkwater,N., Vinh,N., MacRaild,C., Counihan,N., Duffy,S., Wittlin,S., Devine,S., Avery,V., de Koning-Ward,T., Scammells,P. and McGowan,S.
    Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
    Res Sq PubMed  Europe PubMed DOI  I
    2. 2023
  2. Mansouri,M., Daware,K., Webb,C.T. and McGowan,S.
    Understanding the structure and function of Plasmodium aminopeptidases to facilitate drug discovery
    Curr Opin Struct Biol82, 102693-102693. PubMed  Europe PubMed DOI
    3. 2021
  3. Mathew,R., Wunderlich,J., Thivierge,K., Cwiklinski,K., Dumont,C., Tilley,L., Rohrbach,P. and Dalton,J.P.
    Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP)
    Sci Rep11, 2854-2854. PubMed  Europe PubMed DOI
    4. 2019
  4. Vinh,N.B., Drinkwater,N., Malcolm,T.R., Kassiou,M., Lucantoni,L., Grin,P.M., Butler,G.S., Duffy,S., Overall,C.M., Avery,V.M., Scammells,P.J. and McGowan,S.
    Hydroxamic acid inhibitors provide cross-species inhibition of Plasmodium M1 and M17 aminopeptidases
    J Med Chem62, 622-640. PubMed  Europe PubMed DOI  I
  5. Wang,F., Hu,X. and Zhou,B.
    Structural characterization of plasmodial aminopeptidase: a combined molecular docking and QSAR-based in silico approaches
    Mol Divers23, 965-984. PubMed  Europe PubMed DOI
    6. 2018
  6. Moore,D.S., Brines,C., Jewhurst,H., Dalton,J.P. and Tikhonova,I.G.
    Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase
    PLoS Comput Biol14, e1006525-e1006525. PubMed  Europe PubMed DOI  I
  7. Salomon,E., Schmitt,M., Marapaka,A.K., Stamogiannos,A., Revelant,G., Schmitt,C., Alavi,S., Florent,I., Addlagatta,A., Stratikos,E., Tarnus,C. and Albrecht,S.
    Aminobenzosuberone scaffold as a modular chemical tool for the inhibition of therapeutically relevant M1 aminopeptidases
    Molecules23, PubMed  Europe PubMed DOI  I
  8. Yang,W., Riley,B.T., Lei,X., Porebski,B.T., Kass,I., Buckle,A.M. and McGowan,S.
    Mapping the pathway and dynamics of bestatin inhibition of the Plasmodium falciparum M1 aminopeptidase PfA-M1
    ChemMedChem13, 2504-2513. PubMed  Europe PubMed DOI  I
    9. 2017
  9. Gonzalez-Bacerio,J., Maluf,S.E.C., Mendez,Y., Pascual,I., Florent,I., Melo,P.M.S., Budu,A., Ferreira,J.C., Moreno,E., Carmona,A.K., Rivera,D.G., Alonso Del Rivero,M. and Gazarini,M.L.
    KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library
    Bioorg Med Chem25, 4628-4636. PubMed  Europe PubMed DOI  I
  10. Rosati,M., Dalal,S. and Klemba,M.
    Two cap residues in the S1 subsite of a Plasmodium falciparum M1-family aminopeptidase promote broad specificity and enhance catalysis
    Mol Biochem Parasitol217, 7-12. PubMed  Europe PubMed DOI  P
    11. 2016
  11. Drinkwater,N., Vinh,N.B., Mistry,S.N., Bamert,R.S., Ruggeri,C., Holleran,J.P., Loganathan,S., Paiardini,A., Charman,S.A., Powell,A.K., Avery,V.M., McGowan,S. and Scammells,P.J.
    Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions
    Eur J Med Chem110, 43-64. PubMed  Europe PubMed DOI  I
    12. 2015
  12. Drinkwater,N., Bamert,R.S., Sivaraman,K.K., Paiardini,A. and McGowan,S.
    X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17
    Proteins83, 789-795. PubMed  Europe PubMed DOI  S  I
  13. Ruggeri,C., Drinkwater,N., Sivaraman,K.K., Bamert,R.S., McGowan,S. and Paiardini,A.
    Identification and validation of a potent dual inhibitor of the P. falciparum M1 and M17 aminopeptidases using virtual screening
    PLoS ONE10, e0138957-e0138957. PubMed  Europe PubMed DOI  I
    14. 2014
  14. Gonzalez-Bacerio,J., Fando,R., Del Monte-Martinez,A., Charli,J.L. and Chavez,M.L.
    Plasmodium falciparum M1-aminopeptidase: a promising target for the development of antimalarials
    Curr Drug Targets15, 1144-1165. PubMed  Europe PubMed  V  T
  15. Gonzalez-Bacerio,J., Osuna,J., Ponce,A., Fando,R., Figarella,K., Mendez,Y., Charli,J.L. and Chavez,M.D.
    High-level expression in Escherichia coli, purification and kinetic characterization of Plasmodium falciparum M1-aminopeptidase
    Protein Expr Purif104C, 103-114. PubMed  Europe PubMed DOI  E
  16. Sahi,S., Rai,S., Chaudhary,M. and Nain,V.
    Modeling of human M1 aminopeptidases for in silico screening of potential Plasmodium falciparum alanine aminopeptidase (PfA-M1) specific inhibitors
    Bioinformation10, 518-525. PubMed  Europe PubMed DOI  I
    17. 2013
  17. McGowan,S.
    Sitagliptin does not inhibit the M1 alanyl aminopeptidase from Plasmodium falciparum
    Bioinformation9, 661-662. PubMed  Europe PubMed DOI  I
    18. 2012
  18. Dalal,S., Ragheb,D.R. and Klemba,M.
    Engagement of the S1, S1' and S2' subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum
    Mol Biochem Parasitol183, 70-77. PubMed  Europe PubMed DOI  P
  19. Deprez-Poulain,R., Flipo,M., Piveteau,C., Leroux,F., Dassonneville,S., Florent,I., Maes,L., Cos,P. and Deprez,B.
    Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors
    J Med Chem55, 10909-10917. PubMed  Europe PubMed DOI  I
  20. Klemba,M.
    PfA-M1 aminopeptidase (Plasmodium falciparum)
    [ISSN:978-0-12-407744-7]3, 445-448. DOI
    21. 2011
  21. Harbut,M.B., Velmourougane,G., Dalal,S., Reiss,G., Whisstock,J.C., Onder,O., Brisson,D., McGowan,S., Klemba,M. and Greenbaum,D.C.
    Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
    Proc Natl Acad Sci U S A108, E526-E534. PubMed  Europe PubMed DOI  I
  22. Jones,P.M., Robinson,M.W., Dalton,J.P. and George,A.M.
    The Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulations
    PLoS ONE6, e28589-e28589. PubMed  Europe PubMed DOI
  23. Ragheb,D., Dalal,S., Bompiani,K.M., Ray,W.K. and Klemba,M.
    Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism
    J Biol Chem286, 27255-27265. PubMed  Europe PubMed DOI
  24. Velmourougane,G., Harbut,M.B., Dalal,S., McGowan,S., Oellig,C.A., Meinhardt,N., Whisstock,J.C., Klemba,M. and Greenbaum,D.C.
    Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase
    J Med Chem54, 1655-1666. PubMed  Europe PubMed DOI  I
    25. 2010
  25. Azimzadeh,O., Sow,C., Geze,M., Nyalwidhe,J. and Florent,I.
    Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole
    Malar J9, 189-189. PubMed  Europe PubMed DOI
  26. Skinner-Adams,T.S., Stack,C.M., Trenholme,K.R., Brown,C.L., Grembecka,J., Lowther,J., Mucha,A., Drag,M., Kafarski,P., McGowan,S., Whisstock,J.C., Gardiner,D.L. and Dalton,J.P.
    Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
    Trends Biochem Sci35, 53-61. PubMed  Europe PubMed DOI  T
    27. 2009
  27. Klemba,M.
    On the location of the aminopeptidase N homolog PfA-M1 in Plasmodium falciparum
    Proc Natl Acad Sci U S A106, E55-E55. PubMed  Europe PubMed DOI
  28. McGowan,S., Porter,C.J., Lowther,J., Stack,C.M., Golding,S.J., Skinner-Adams,T.S., Trenholme,K.R., Teuscher,F., Donnelly,S.M., Grembecka,J., Mucha,A., Kafarski,P., Degori,R., Buckle,A.M., Gardiner,D.L., Whisstock,J.C. and Dalton,J.P.
    Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
    Proc Natl Acad Sci U S A106, 2537-2542. PubMed  Europe PubMed DOI  S  T  I
    29. 2007
  29. Dalal,S. and Klemba,M.
    Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum
    J Biol Chem282, 35978-35987. PubMed  Europe PubMed DOI
  30. Flipo,M., Beghyn,T., Leroux,V., Florent,I., Deprez,B.P. and Deprez-Poulain,R.F.
    Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents
    J Med Chem50, 1322-1334. PubMed  Europe PubMed DOI  T  I
    31. 2003
  31. [YEAR:18-8-2003]Flipo,M., Florent,I., Grellier,P., Sergheraert,C. and Deprez-Poulain,R.
    Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors
    Bioorg Med Chem Lett13, 2659-2662. PubMed  Europe PubMed DOI  I
    32. 2002
  32. Allary,M., Schrevel,J. and Florent,I.
    Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase
    Parasitology125, 1-10. PubMed  Europe PubMed DOI
    33. 1998
  33. [YEAR:30-11-1998]Florent,I., Derhy,Z., Allary,M., Monsigny,M., Mayer,R. and Schrevel,J.
    A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages
    Mol Biochem Parasitol97, 149-160. PubMed  Europe PubMed DOI

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