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Literature for peptidase M01.018: endoplasmic reticulum aminopeptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Su,S.H., Cai,X.Q., Li,Y.H., Xu,A.H., Huang,Q., Niu,H., You,Q.H. and Sun,G.Y.
    The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis
    BMC Infect Dis25, 178-178. PubMed  Europe PubMed DOI  M
    2. 2024
  2. Georgaki,G., Mpakali,A., Trakada,M., Papakyriakou,A. and Stratikos,E.
    Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties
    Front Immunol15, 1415964-1415964. PubMed  Europe PubMed DOI
  3. Luo,Z., Huang,Y., Batra,N., Chen,Y., Huang,H., Wang,Y., Zhang,Z., Li,S., Chen,C.Y., Wang,Z., Sun,J., Wang,Q.J., Yang,D., Lu,B., Conway,J.F., Li,L.Y., Yu,A.M. and Li,S.
    Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
    Nat Commun15, 255-255. PubMed  Europe PubMed DOI
  4. Pande,S. and Guo,H.C.
    Structure-guided discovery of aminopeptidase ERAP1 variants capable of processing antigens with novel PC anchor specificities
    Immunology171, 131-145. PubMed  Europe PubMed DOI
  5. Tiburca,L., Zaha,D.C., Jurca,M.C., Severin,E., Jurca,A. and Jurca,A.D.
    The Role of Aminopeptidase ERAP1 in Human Pathology-A Review
    Curr Issues Mol Biol46, 1651-1667. PubMed  Europe PubMed DOI  V
    6. 2023
  6. Abo El Nazar,S., Ghazy,A.A., Amer,I., Tawfik,S., Nassar,M. and Osman,E.M.
    Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-lambda4) in Egyptian patients with type 1 diabetes mellitus
    Egypt J Immunol30, 116-124. PubMed  Europe PubMed
  7. Evnouchidou,I., Koumantou,D., Nugue,M. and Saveanu,L.
    M1-aminopeptidase family - beyond antigen-trimming activities
    Curr Opin Immunol83, 102337-102337. PubMed  Europe PubMed DOI  V
  8. Limanaqi,F., Vicentini,C., Saulle,I., Clerici,M. and Biasin,M.
    The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus
    Life Sci323, 121701-121701. PubMed  Europe PubMed DOI  V
  9. Schmidt,K., Leisegang,M. and Kloetzel,P.M.
    ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes
    Mol Immunol154, 61-68. PubMed  Europe PubMed DOI
  10. Tedeschi,V., Paldino,G., Alba,J., Molteni,E., Paladini,F., Scrivo,R., Congia,M., Cauli,A., Caccavale,R., Paroli,M., Di Franco,M., Tuosto,L., Sorrentino,R., D'Abramo,M. and Fiorillo,M.T.
    ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes
    Int J Mol Sci24, PubMed  Europe PubMed DOI  M
  11. Temponeras,I., Samiotaki,M., Koumantou,D., Nikopaschou,M., Kuiper,J.J.W., Panayotou,G. and Stratikos,E.
    Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
    Eur J Immunol53, e2350449-e2350449. PubMed  Europe PubMed DOI
    12. 2022
  12. Blake,M.K., O'Connell,P., Pepelyayeva,Y., Godbehere,S., Aldhamen,Y.A. and Amalfitano,A.
    ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses
    BMC Immunol23, 9-9. PubMed  Europe PubMed DOI
  13. Cavers,A., Kugler,M.C., Ozguler,Y., Al-Obeidi,A.F., Hatemi,G., Ueberheide,B.M., Ucar,D., Manches,O. and Nowatzky,J.
    Behcet's disease risk-variant HLA-B51/ERAP1-Hap10 alters human CD8 T cell immunity
    Ann Rheum Dis81, 1603-1611. PubMed  Europe PubMed DOI  M
  14. Liu,H., Hu,B., Huang,J., Wang,Q., Wang,F., Pan,F. and Chen,L.
    Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides
    Front Microbiol13, 829241-829241. PubMed  Europe PubMed DOI  K
  15. Liu,S., Lu,J., Wu,J., Feng,D., Wang,Y., Su,X. and Cao,H.
    Structural and biochemical insights into the association between ERAP1 polymorphism and autoimmune diseases
    Biochem Biophys Res Commun632, 189-194. PubMed  Europe PubMed DOI  V
  16. Martin-Esteban,A., Rodriguez,J.C., Peske,D., Lopez de Castro,J.A., Shastri,N. and Sadegh-Nasseri,S.
    The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
    Front Immunol13, 1066483-1066483. PubMed  Europe PubMed DOI
  17. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol13, 1002375-1002375. PubMed  Europe PubMed DOI  M
  18. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol13, 1002375- PubMed  Europe PubMed
  19. [YEAR:19-11-2022]Müller,L., Burton,A.K., Tayler,C.L., Rowedder,J.E., Hutchinson,J.P., Peace,S., Quayle,J.M., Leveridge,M.V., Annan,R.S., Trost,M., Peltier-Heap,R.E. and Dueñas,M.E.
    A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1
    SLAS DiscovS2472-5552(22)13707-X-S2472-5552(22)13707-X. PubMed  Europe PubMed
  20. Niu,Y., Jiang,H., Yin,H., Wang,F., Hu,R., Hu,X., Peng,B., Shu,Y., Li,Z., Chen,S. and Guo,F.
    Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination
    Diabetes71, 921-933. PubMed  Europe PubMed DOI  K
  21. Papakyriakou,A., Mpakali,A. and Stratikos,E.
    Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
    Front Immunol13, 863529-863529. PubMed  Europe PubMed DOI
  22. Rahmawati,L.D., Soeroso,J. and Aryati
    The roles of Single Nucleotide Polymorphism (SNP) Endoplasmic Reticulum Aminopeptidase 1 (ERAP 1) gene in axial spondyloarthritis Indonesian adults
    Ann Med Surg (Lond)77, 103675-103675. PubMed  Europe PubMed DOI
    23. 2021
  23. D'Amico,S., Tempora,P., Lucarini,V., Melaiu,O., Gaspari,S., Algeri,M. and Fruci,D.
    ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
    Int J Mol Sci22, PubMed  Europe PubMed DOI  V
  24. Du,K., Sheng,L., Luo,X., Fan,G., Shen,D., Wu,C. and Shen,R.
    A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells
    Spectrochim Acta A Mol Biomol Spectrosc249, 119328-119328. PubMed  Europe PubMed DOI
  25. Gelfman,S., Monnet,D., Ligocki,A.J., Tabary,T., Moscati,A., Bai,X., Freudenberg,J., Cooper,B., Kosmicki,J.A., Wolf,S., Ferreira,M.A.R., Overton,J., Weyne,J., Stahl,E.A., Baras,A., Romano,C., Cohen,J.H.M., Coppola,G. and Brezin,A.
    ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers
    Invest Ophthalmol Vis Sci62, 3-3. PubMed  Europe PubMed DOI
  26. Hutchinson,J.P., Temponeras,I., Kuiper,J., Cortes,A., Korczynska,J., Kitchen,S. and Stratikos,E.
    Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties
    J Biol Chem100443-100443. PubMed  Europe PubMed DOI
  27. [YEAR:6-9-2021]Maben,Z., Arya,R., Georgiadis,D., Stratikos,E. and Stern,L.J.
    Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism
    Nat Commun12, 5302-5302. PubMed  Europe PubMed
    28. 2020
  28. Chen,L., Shi,H., Koftori,D., Sekine,T., Nicastri,A., Ternette,N. and Bowness,P.
    Identification of an unconventional subpeptidome bound to the Behcet's disease-associated HLA-B*51:01 that is regulated by endoplasmic reticulum aminopeptidase 1 (ERAP1)
    Mol Cell Proteomics19, 871-883. PubMed  Europe PubMed DOI
  29. Gao,S., Xu,T., Liang,W., Xun,C., Deng,Q., Guo,H. and Sheng,W.
    Association of rs27044 and rs30187 polymorphisms in endoplasmic reticulum aminopeptidase 1 gene and ankylosing spondylitis susceptibility: A meta-analysis
    Int J Rheum Dis23, 499-510. PubMed  Europe PubMed DOI  M
  30. Joob,B. and Wiwanitkit,V.
    Endoplasmic reticulum aminopeptidase protein 1 and Behcet's syndrome
    Intern Emerg Med15, 733-733. PubMed  Europe PubMed DOI  M
  31. Li,C., Li,Y., Yan,Z., Dai,S., Liu,S., Wang,X., Wang,J., Zhang,X., Shi,L. and Yao,Y.
    Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population
    BMC Cancer20, 341-341. PubMed  Europe PubMed DOI  M
  32. Liddle,J., Hutchinson,J.P., Kitchen,S., Rowland,P., Neu,M., Cecconie,T., Holmes,D.S., Jones,E., Korczynska,J., Koumantou,D., Lea,J.D., Nickels,L., Pemberton,M., Phillipou,A., Schneck,J.L., Sheehan,H., Tinworth,C.P., Uings,I., Wojno-Picon,J., Young,R.J. and Stratikos,E.
    Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation
    J Med Chem63, 3348-3358. PubMed  Europe PubMed DOI
  33. Maben,Z., Arya,R., Rane,D., An,W.F., Metkar,S., Hickey,M., Bender,S., Ali,A., Nguyen,T.T., Evnouchidou,I., Schilling,R., Stratikos,E., Golden,J. and Stern,L.J.
    Discovery of selective inhibitors of endoplasmic reticulum aminopeptidase 1
    J Med Chem63, 103-121. PubMed  Europe PubMed DOI  I
  34. Mavridis,G., Arya,R., Domnick,A., Zoidakis,J., Makridakis,M., Vlahou,A., Mpakali,A., Lelis,A., Georgiadis,D., Tampe,R., Papakyriakou,A., Stern,L.J. and Stratikos,E.
    A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1
    J Biol Chem295, 7193-7210. PubMed  Europe PubMed DOI
  35. Niepieklo-Miniewska,W., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wisniewski,A., Piekarska,K., Nowak,I. and Kusnierczyk,P.
    Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence
    Hum Immunol PubMed  Europe PubMed DOI
  36. Paladini,F., Fiorillo,M.T., Tedeschi,V., Mattorre,B. and Sorrentino,R.
    The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
    Front Immunol11, 1576-1576. PubMed  Europe PubMed
  37. Textoris-Taube,K., Cammann,C., Henklein,P., Topfstedt,E., Ebstein,F., Henze,S., Liepe,J., Zhao,F., Schadendorf,D., Dahlmann,B., Uckert,W., Paschen,A., Mishto,M. and Seifert,U.
    ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope
    Eur J Immunol50, 270-283. PubMed  Europe PubMed DOI
  38. Tsujimoto,M., Aoki,K., Ohnishi,A. and Goto,Y.
    Endoplasmic reticulum aminopeptidase 1 beyond antigenic peptide-processing enzyme in the endoplasmic reticulum
    Biol Pharm Bull43, 207-214. PubMed  Europe PubMed DOI
  39. Vidal-Castineira,J.R., Lopez-Vazquez,A., Diaz-Bulnes,P., Diaz-Coto,S., Marquez-Kisinousky,L., Martinez-Borra,J., Navascues,C.A., Sanz-Cameno,P., de la Vega,J., Astudillo,A., Rodriguez,M. and Lopez-Larrea,C.
    Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection
    J Mol Med (Berl)98, 1245-1254. PubMed  Europe PubMed DOI
  40. Zavattaro,E., Ramezani,M. and Sadeghi,M.
    Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: a systematic review and meta-analysis
    Gene736, 144416-144416. PubMed  Europe PubMed DOI  M
  41. Zhang,S., Liu,S., Liu,N., Li,C., Wang,H., Shi,L., Zhang,X., Bao,L., Yao,Y. and Shi,L.
    Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese
    Front Genet11, 566190-566190. PubMed  Europe PubMed
    42. 2019
  42. Georgiadis,D., Mpakali,A., Koumantou,D. and Stratikos,E.
    Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application
    Curr Med Chem26, 2715-2729. PubMed  Europe PubMed DOI  I
  43. Giastas,P., Neu,M., Rowland,P. and Stratikos,E.
    High-resolution crystal structure of endoplasmic reticulum aminopeptidase 1 with bound phosphinic transition-state analogue inhibitor
    ACS Med Chem Lett10, 708-713. PubMed  Europe PubMed DOI  S  I
  44. Giastas,P., Mpakali,A., Papakyriakou,A., Lelis,A., Kokkala,P., Neu,M., Rowland,P., Liddle,J., Georgiadis,D. and Stratikos,E.
    Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
    Proc Natl Acad Sci U S A116, 126709-26716. PubMed  Europe PubMed DOI  S
  45. Goto,Y., Nakamura,T.J., Ogawa,K., Hattori,A. and Tsujimoto,M.
    Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1
    J Biochem165, 159-165. PubMed  Europe PubMed DOI  K
  46. Hanson,A.L., Morton,C.J., Parker,M.W., Bessette,D. and Kenna,T.J.
    The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease
    Hum Immunol80, 281-289. PubMed  Europe PubMed DOI
  47. Koumantou,D., Barnea,E., Martin-Esteban,A., Maben,Z., Papakyriakou,A., Mpakali,A., Kokkala,P., Pratsinis,H., Georgiadis,D., Stern,L.J., Admon,A. and Stratikos,E.
    Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)
    Cancer Immunol Immunother68, 1245-1261. PubMed  Europe PubMed DOI  I
  48. [YEAR:6-12-2019]Li,L., Batliwala,M. and Bouvier,M.
    ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation
    J Biol Chem294, 18534-18544. PubMed  Europe PubMed
  49. Mpakali,A., Maben,Z., Stern,L.J. and Stratikos,E.
    Molecular pathways for antigenic peptide generation by ER aminopeptidase 1
    Mol Immunol113, 50-57. PubMed  Europe PubMed DOI
  50. Niepieklo-Miniewska,W., Mpakali,A., Stratikos,E., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wilczynska,K., Nowak,I., Wisniewski,A., Zwolinska,K., Poninska,J., Ploski,R., Szepietowski,J.C. and Kusnierczyk,P.
    Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro
    J Eur Acad Dermatol Venereol33, 906-911. PubMed  Europe PubMed DOI  M
  51. [YEAR:1-11-2019]Ranjit,S., Wong,J.Y., Tan,J.W., Sin,T.C., Lee,J.M., Yin Han,W.K., Pojoga,L.H., Brooks,D.L., Garza,A.E., Maris,S.A., Katayama,I.A., Williams,J.S., Rivera,A., Adler,G.K., Williams,G.H. and Romero,J.R.
    Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses
    JCI Insight4, e129615-e129615. PubMed  Europe PubMed
    52. 2018
  52. Aoki,K., Furuya,A., Matsumoto,K. and Tsujimoto,M.
    The gene expression of two endoplasmic reticulum aminopeptidase 1 isoforms is regulated by distinct posttranscriptional mechanisms
    Biochem Biophys Res Commun503, 3180-3185. PubMed  Europe PubMed DOI  R
  53. Goto,Y., Ogawa,Y., Tsumoto,H., Miura,Y., Nakamura,T.J., Ogawa,K., Akimoto,Y., Kawakami,H., Endo,T., Yanoshita,R. and Tsujimoto,M.
    Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation
    Biochim Biophys Acta1865, 874-888. PubMed  Europe PubMed DOI
  54. Papakyriakou,A., Reeves,E., Beton,M., Mikolajek,H., Douglas,L., Cooper,G., Elliott,T., Werner,J.M. and James,E.
    The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1
    J Biol Chem293, 7538-7548. PubMed  Europe PubMed DOI
  55. [YEAR:20-8-2018]Pepelyayeva,Y., Rastall,D.P.W., Aldhamen,Y.A., O'Connell,P., Raehtz,S., Alyaqoub,F.S., Blake,M.K., Raedy,A.M., Angarita,A.M., Abbas,A.M., Pereira-Hicks,C.N., Roosa,S.G., McCabe,L. and Amalfitano,A.
    ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis
    Sci Rep8, 12464-12464. PubMed  Europe PubMed
  56. Zhang,J., Yang,S.J., Gonzalez,F., Yang,J., Zhang,Y., He,M., Shastri,N. and Murthy,N.
    A peptide-based fluorescent probe images ERAAP activity in cells and in high throughput assays
    Chem Commun (Camb)54, 7215-7218. PubMed  Europe PubMed DOI  L
    57. 2017
  57. Guasp,P., Barnea,E., Gonzalez-Escribano,M.F., Jimenez-Reinoso,A., Regueiro,J.R., Admon,A. and Lopez de Castro,J.A.
    The Behcet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing
    J Biol Chem292, 9680-9689. PubMed  Europe PubMed DOI  M  P
  58. Romania,P., Cifaldi,L., Pignoloni,B., Starc,N., D'Alicandro,V., Melaiu,O., Pira,G.L., Giorda,E., Carrozzo,R., Bergvall,M., Bergstrom,T., Alfredsson,L., Olsson,T., Kockum,I., Seppala,I., Lehtimaki,T., Hurme,M.A., Hengel,H., Santoni,A., Cerboni,C., Locatelli,F., D'Amato,M. and Fruci,D.
    Identification of a genetic variation in ERAP1 aminopeptidase that prevents human cytomegalovirus miR-UL112-5p-mediated immunoevasion
    Cell Rep20, 846-853. PubMed  Europe PubMed DOI  M
  59. Stamogiannos,A., Maben,Z., Papakyriakou,A., Mpakali,A., Kokkala,P., Georgiadis,D., Stern,L.J. and Stratikos,E.
    Critical role of interdomain interactions in the conformational change and catalytic mechanism of endoplasmic reticulum aminopeptidase 1
    Biochemistry56, 1546-1558. PubMed  Europe PubMed DOI  I
  60. Wang,X., Ma,J., Ma,J., Wen,Y., Meng,L., Yang,H., Zhang,R. and Hao,D.
    Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis
    Mol Med Rep16, 6532-6543. PubMed  Europe PubMed DOI  M
  61. Xu,S., Liu,H.W., Hu,X.X., Huan,S.Y., Zhang,J., Liu,Y.C., Yuan,L., Qu,F.L., Zhang,X.B. and Tan,W.
    Visualization of endoplasmic reticulum aminopeptidase 1 under different redox conditions with a two-photon fluorescent probe
    Anal Chem89, 7641-7648. PubMed  Europe PubMed DOI  L
    62. 2016
  62. Chen,L., Ridley,A., Hammitzsch,A., Al-Mossawi,M.H., Bunting,H., Georgiadis,D., Chan,A., Kollnberger,S. and Bowness,P.
    Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
    Ann Rheum Dis75, 916-923. PubMed  Europe PubMed DOI  K
  63. Kokkala,P., Mpakali,A., Mauvais,F.X., Papakyriakou,A., Daskalaki,I., Petropoulou,I., Kavvalou,S., Papathanasopoulou,M., Agrotis,S., Fonsou,T.M., van Endert,P., Stratikos,E. and Georgiadis,D.
    Optimization and structure-activity relationships of phosphinic pseudotripeptide inhibitors of aminopeptidases that generate antigenic peptides
    J Med Chem59, 9107-9123. PubMed  Europe PubMed DOI  I
  64. Pedersen,N.C., Dhanota,J.K. and Liu,H.
    Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs
    Vet Immunol Immunopathol179, 46-57. PubMed  Europe PubMed DOI  M
  65. Sezgin,G., Dabak,R., Kaya,F.O., Kotevoglu,N., Uygur-Bayramicli,O. and Nalbant,S.
    The association of endoplasmic reticulum aminopeptidase-1 (ERAP-1) with Familial Mediterranean Fever (FMF)
    United European Gastroenterol J4, 92-96. PubMed  Europe PubMed DOI  M
  66. Stamogiannos,A., Papakyriakou,A., Mauvais,F.X., van Endert,P. and Stratikos,E.
    Screening identifies thimerosal as a selective inhibitor of endoplasmic reticulum aminopeptidase 1
    ACS Med Chem Lett7, 681-685. PubMed  Europe PubMed DOI  I
  67. Sui,L., Gandhi,A. and Guo,H.C.
    Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1
    Mol Immunol80, 41-49. PubMed  Europe PubMed DOI  S
  68. Takeuchi,M., Ombrello,M.J., Kirino,Y., Erer,B., Tugal-Tutkun,I., Seyahi,E., Ozyazgan,Y., Watts,N.R., Gul,A., Kastner,D.L. and Remmers,E.F.
    A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behcet's disease in HLA-B*51 carriers
    Ann Rheum Dis75, 2208-2211. PubMed  Europe PubMed DOI  M
    69. 2015
  69. Aldhamen,Y.A., Pepelyayeva,Y., Rastall,D.P., Seregin,S.S., Zervoudi,E., Koumantou,D., Aylsworth,C.F., Quiroga,D., Godbehere,S., Georgiadis,D., Stratikos,E. and Amalfitano,A.
    Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells
    J Innate Immun7, 275-289. PubMed  Europe PubMed DOI  M
  70. [YEAR:21-5-2015]Cortes,A., Pulit,S.L., Leo,P.J., Pointon,J.J., Robinson,P.C., Weisman,M.H., Ward,M., Gensler,L.S., Zhou,X., Garchon,H.J., Chiocchia,G., Nossent,J., Lie,B.A., Førre,Ø., Tuomilehto,J., Laiho,K., Bradbury,L.A., Elewaut,D., Burgos-Vargas,R., Stebbings,S., Appleton,L., Farrah,C., Lau,J., Haroon,N., Mulero,J., Blanco,F.J., Gonzalez-Gay,M.A., Lopez-Larrea,C., Bowness,P., Gaffney,K., Gaston,H., Gladman,D.D., Rahman,P., Maksymowych,W.P., Crusius,J.B., van der Horst-Bruinsma IE, Valle-Oñate,R., Romero-Sánchez,C., Hansen,I.M., Pimentel-Santos,F.M., Inman,R.D., Martin,J., Breban,M., Wordsworth,B.P., Reveille,J.D., Evans,D.M., de Bakker,P.I. and Brown,M.A.
    Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
    Nat Commun6, 7146-7146. PubMed  Europe PubMed
  71. Goto,Y., Ogawa,K., Nakamura,T.J., Hattori,A. and Tsujimoto,M.
    Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages
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