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Literature for peptidase M01.018: endoplasmic reticulum aminopeptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kang,J., Teplensky,M.H., Dittmar,J.W., Evangelopoulos,M., Hwang,J. and Mirkin,C.A.<br>Controlling intracellular processing to enhance spherical nucleic acid immune stimulation<br>Proc Natl Acad Sci U S A (2025) 122, e2409554122-e2409554122. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Su,S.H., Cai,X.Q., Li,Y.H., Xu,A.H., Huang,Q., Niu,H., You,Q.H. and Sun,G.Y.<br>The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis<br>BMC Infect Dis (2025) 25, 178-178. PubMed  Europe PubMed DOI  PMC  EPMC  M
    3. 2024
  3. Georgaki,G., Mpakali,A., Trakada,M., Papakyriakou,A. and Stratikos,E.<br>Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties<br>Front Immunol (2024) 15, 1415964-1415964. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Luo,Z., Huang,Y., Batra,N., Chen,Y., Huang,H., Wang,Y., Zhang,Z., Li,S., Chen,C.Y., Wang,Z., Sun,J., Wang,Q.J., Yang,D., Lu,B., Conway,J.F., Li,L.Y., Yu,A.M. and Li,S.<br>Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy<br>Nat Commun (2024) 15, 255-255. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Pande,S. and Guo,H.C.<br>Structure-guided discovery of aminopeptidase ERAP1 variants capable of processing antigens with novel PC anchor specificities<br>Immunology (2024) 171, 131-145. PubMed  Europe PubMed DOI
  6. Tiburca,L., Zaha,D.C., Jurca,M.C., Severin,E., Jurca,A. and Jurca,A.D.<br>The Role of Aminopeptidase ERAP1 in Human Pathology-A Review<br>Curr Issues Mol Biol (2024) 46, 1651-1667. PubMed  Europe PubMed DOI  PMC  EPMC  V
    7. 2023
  7. Abo El Nazar,S., Ghazy,A.A., Amer,I., Tawfik,S., Nassar,M. and Osman,E.M.<br>Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-lambda4) in Egyptian patients with type 1 diabetes mellitus<br>Egypt J Immunol (2023) 30, 116-124. PubMed  Europe PubMed
  8. Evnouchidou,I., Koumantou,D., Nugue,M. and Saveanu,L.<br>M1-aminopeptidase family - beyond antigen-trimming activities<br>Curr Opin Immunol (2023) 83, 102337-102337. PubMed  Europe PubMed DOI  V
  9. Limanaqi,F., Vicentini,C., Saulle,I., Clerici,M. and Biasin,M.<br>The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus<br>Life Sci (2023) 323, 121701-121701. PubMed  Europe PubMed DOI  V
  10. Schmidt,K., Leisegang,M. and Kloetzel,P.M.<br>ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes<br>Mol Immunol (2023) 154, 61-68. PubMed  Europe PubMed DOI
  11. Tedeschi,V., Paldino,G., Alba,J., Molteni,E., Paladini,F., Scrivo,R., Congia,M., Cauli,A., Caccavale,R., Paroli,M., Di Franco,M., Tuosto,L., Sorrentino,R., D'Abramo,M. and Fiorillo,M.T.<br>ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  M
  12. Temponeras,I., Samiotaki,M., Koumantou,D., Nikopaschou,M., Kuiper,J.J.W., Panayotou,G. and Stratikos,E.<br>Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1<br>Eur J Immunol (2023) 53, e2350449-e2350449. PubMed  Europe PubMed DOI
    13. 2022
  13. Blake,M.K., O'Connell,P., Pepelyayeva,Y., Godbehere,S., Aldhamen,Y.A. and Amalfitano,A.<br>ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses<br>BMC Immunol (2022) 23, 9-9. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Cavers,A., Kugler,M.C., Ozguler,Y., Al-Obeidi,A.F., Hatemi,G., Ueberheide,B.M., Ucar,D., Manches,O. and Nowatzky,J.<br>Behcet's disease risk-variant HLA-B51/ERAP1-Hap10 alters human CD8 T cell immunity<br>Ann Rheum Dis (2022) 81, 1603-1611. PubMed  Europe PubMed DOI  PMC  EPMC  M
  15. Liu,H., Hu,B., Huang,J., Wang,Q., Wang,F., Pan,F. and Chen,L.<br>Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides<br>Front Microbiol (2022) 13, 829241-829241. PubMed  Europe PubMed DOI  PMC  EPMC  K
  16. Liu,S., Lu,J., Wu,J., Feng,D., Wang,Y., Su,X. and Cao,H.<br>Structural and biochemical insights into the association between ERAP1 polymorphism and autoimmune diseases<br>Biochem Biophys Res Commun (2022) 632, 189-194. PubMed  Europe PubMed DOI  V
  17. Martin-Esteban,A., Rodriguez,J.C., Peske,D., Lopez de Castro,J.A., Shastri,N. and Sadegh-Nasseri,S.<br>The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities<br>Front Immunol (2022) 13, 1066483-1066483. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.<br>The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation<br>Front Immunol (2022) 13, 1002375- PubMed  Europe PubMed
  19. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.<br>The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation<br>Front Immunol (2022) 13, 1002375-1002375. PubMed  Europe PubMed DOI  PMC  EPMC  M
  20. [YEAR:19-11-2022]Müller,L., Burton,A.K., Tayler,C.L., Rowedder,J.E., Hutchinson,J.P., Peace,S., Quayle,J.M., Leveridge,M.V., Annan,R.S., Trost,M., Peltier-Heap,R.E. and Dueñas,M.E.<br>A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1<br>SLAS Discov (19-11-2022) , S2472-5552(22)13707-X-S2472-5552(22)13707-X. PubMed  Europe PubMed
  21. Niu,Y., Jiang,H., Yin,H., Wang,F., Hu,R., Hu,X., Peng,B., Shu,Y., Li,Z., Chen,S. and Guo,F.<br>Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination<br>Diabetes (2022) 71, 921-933. PubMed  Europe PubMed DOI  K
  22. Papakyriakou,A., Mpakali,A. and Stratikos,E.<br>Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation<br>Front Immunol (2022) 13, 863529-863529. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Rahmawati,L.D., Soeroso,J. and Aryati<br>The roles of Single Nucleotide Polymorphism (SNP) Endoplasmic Reticulum Aminopeptidase 1 (ERAP 1) gene in axial spondyloarthritis Indonesian adults<br>Ann Med Surg (Lond) (2022) 77, 103675-103675. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2021
  24. D'Amico,S., Tempora,P., Lucarini,V., Melaiu,O., Gaspari,S., Algeri,M. and Fruci,D.<br>ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
  25. Du,K., Sheng,L., Luo,X., Fan,G., Shen,D., Wu,C. and Shen,R.<br>A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells<br>Spectrochim Acta A Mol Biomol Spectrosc (2021) 249, 119328-119328. PubMed  Europe PubMed DOI
  26. Gelfman,S., Monnet,D., Ligocki,A.J., Tabary,T., Moscati,A., Bai,X., Freudenberg,J., Cooper,B., Kosmicki,J.A., Wolf,S., Ferreira,M.A.R., Overton,J., Weyne,J., Stahl,E.A., Baras,A., Romano,C., Cohen,J.H.M., Coppola,G. and Brezin,A.<br>ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers<br>Invest Ophthalmol Vis Sci (2021) 62, 3-3. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Hutchinson,J.P., Temponeras,I., Kuiper,J., Cortes,A., Korczynska,J., Kitchen,S. and Stratikos,E.<br>Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties<br>J Biol Chem (2021) , 100443-100443. PubMed  Europe PubMed DOI
  28. [YEAR:6-9-2021]Maben,Z., Arya,R., Georgiadis,D., Stratikos,E. and Stern,L.J.<br>Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism<br>Nat Commun (6-9-2021) 12, 5302-5302. PubMed  Europe PubMed
    29. 2020
  29. Chen,L., Shi,H., Koftori,D., Sekine,T., Nicastri,A., Ternette,N. and Bowness,P.<br>Identification of an unconventional subpeptidome bound to the Behcet's disease-associated HLA-B*51:01 that is regulated by endoplasmic reticulum aminopeptidase 1 (ERAP1)<br>Mol Cell Proteomics (2020) 19, 871-883. PubMed  Europe PubMed DOI
  30. Gao,S., Xu,T., Liang,W., Xun,C., Deng,Q., Guo,H. and Sheng,W.<br>Association of rs27044 and rs30187 polymorphisms in endoplasmic reticulum aminopeptidase 1 gene and ankylosing spondylitis susceptibility: A meta-analysis<br>Int J Rheum Dis (2020) 23, 499-510. PubMed  Europe PubMed DOI  M
  31. Joob,B. and Wiwanitkit,V.<br>Endoplasmic reticulum aminopeptidase protein 1 and Behcet's syndrome<br>Intern Emerg Med (2020) 15, 733-733. PubMed  Europe PubMed DOI  M
  32. Li,C., Li,Y., Yan,Z., Dai,S., Liu,S., Wang,X., Wang,J., Zhang,X., Shi,L. and Yao,Y.<br>Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population<br>BMC Cancer (2020) 20, 341-341. PubMed  Europe PubMed DOI  PMC  EPMC  M
  33. Liddle,J., Hutchinson,J.P., Kitchen,S., Rowland,P., Neu,M., Cecconie,T., Holmes,D.S., Jones,E., Korczynska,J., Koumantou,D., Lea,J.D., Nickels,L., Pemberton,M., Phillipou,A., Schneck,J.L., Sheehan,H., Tinworth,C.P., Uings,I., Wojno-Picon,J., Young,R.J. and Stratikos,E.<br>Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation<br>J Med Chem (2020) 63, 3348-3358. PubMed  Europe PubMed DOI
  34. Maben,Z., Arya,R., Rane,D., An,W.F., Metkar,S., Hickey,M., Bender,S., Ali,A., Nguyen,T.T., Evnouchidou,I., Schilling,R., Stratikos,E., Golden,J. and Stern,L.J.<br>Discovery of selective inhibitors of endoplasmic reticulum aminopeptidase 1<br>J Med Chem (2020) 63, 103-121. PubMed  Europe PubMed DOI  I
  35. Mavridis,G., Arya,R., Domnick,A., Zoidakis,J., Makridakis,M., Vlahou,A., Mpakali,A., Lelis,A., Georgiadis,D., Tampe,R., Papakyriakou,A., Stern,L.J. and Stratikos,E.<br>A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1<br>J Biol Chem (2020) 295, 7193-7210. PubMed  Europe PubMed DOI
  36. Niepieklo-Miniewska,W., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wisniewski,A., Piekarska,K., Nowak,I. and Kusnierczyk,P.<br>Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence<br>Hum Immunol (2020) PubMed  Europe PubMed DOI
  37. Paladini,F., Fiorillo,M.T., Tedeschi,V., Mattorre,B. and Sorrentino,R.<br>The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease<br>Front Immunol (2020) 11, 1576-1576. PubMed  Europe PubMed
  38. Textoris-Taube,K., Cammann,C., Henklein,P., Topfstedt,E., Ebstein,F., Henze,S., Liepe,J., Zhao,F., Schadendorf,D., Dahlmann,B., Uckert,W., Paschen,A., Mishto,M. and Seifert,U.<br>ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope<br>Eur J Immunol (2020) 50, 270-283. PubMed  Europe PubMed DOI
  39. Tsujimoto,M., Aoki,K., Ohnishi,A. and Goto,Y.<br>Endoplasmic reticulum aminopeptidase 1 beyond antigenic peptide-processing enzyme in the endoplasmic reticulum<br>Biol Pharm Bull (2020) 43, 207-214. PubMed  Europe PubMed DOI
  40. Vidal-Castineira,J.R., Lopez-Vazquez,A., Diaz-Bulnes,P., Diaz-Coto,S., Marquez-Kisinousky,L., Martinez-Borra,J., Navascues,C.A., Sanz-Cameno,P., de la Vega,J., Astudillo,A., Rodriguez,M. and Lopez-Larrea,C.<br>Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection<br>J Mol Med (Berl) (2020) 98, 1245-1254. PubMed  Europe PubMed DOI
  41. Zavattaro,E., Ramezani,M. and Sadeghi,M.<br>Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: a systematic review and meta-analysis<br>Gene (2020) 736, 144416-144416. PubMed  Europe PubMed DOI  M
  42. Zhang,S., Liu,S., Liu,N., Li,C., Wang,H., Shi,L., Zhang,X., Bao,L., Yao,Y. and Shi,L.<br>Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese<br>Front Genet (2020) 11, 566190-566190. PubMed  Europe PubMed
    43. 2019
  43. Georgiadis,D., Mpakali,A., Koumantou,D. and Stratikos,E.<br>Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application<br>Curr Med Chem (2019) 26, 2715-2729. PubMed  Europe PubMed DOI  I
  44. Giastas,P., Neu,M., Rowland,P. and Stratikos,E.<br>High-resolution crystal structure of endoplasmic reticulum aminopeptidase 1 with bound phosphinic transition-state analogue inhibitor<br>ACS Med Chem Lett (2019) 10, 708-713. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  45. Giastas,P., Mpakali,A., Papakyriakou,A., Lelis,A., Kokkala,P., Neu,M., Rowland,P., Liddle,J., Georgiadis,D. and Stratikos,E.<br>Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1<br>Proc Natl Acad Sci U S A (2019) 116, 126709-26716. PubMed  Europe PubMed DOI  S
  46. Goto,Y., Nakamura,T.J., Ogawa,K., Hattori,A. and Tsujimoto,M.<br>Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1<br>J Biochem (2019) 165, 159-165. PubMed  Europe PubMed DOI  K
  47. Hanson,A.L., Morton,C.J., Parker,M.W., Bessette,D. and Kenna,T.J.<br>The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease<br>Hum Immunol (2019) 80, 281-289. PubMed  Europe PubMed DOI
  48. Koumantou,D., Barnea,E., Martin-Esteban,A., Maben,Z., Papakyriakou,A., Mpakali,A., Kokkala,P., Pratsinis,H., Georgiadis,D., Stern,L.J., Admon,A. and Stratikos,E.<br>Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)<br>Cancer Immunol Immunother (2019) 68, 1245-1261. PubMed  Europe PubMed DOI  I
  49. [YEAR:6-12-2019]Li,L., Batliwala,M. and Bouvier,M.<br>ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation<br>J Biol Chem (6-12-2019) 294, 18534-18544. PubMed  Europe PubMed
  50. Mpakali,A., Maben,Z., Stern,L.J. and Stratikos,E.<br>Molecular pathways for antigenic peptide generation by ER aminopeptidase 1<br>Mol Immunol (2019) 113, 50-57. PubMed  Europe PubMed DOI
  51. Niepieklo-Miniewska,W., Mpakali,A., Stratikos,E., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wilczynska,K., Nowak,I., Wisniewski,A., Zwolinska,K., Poninska,J., Ploski,R., Szepietowski,J.C. and Kusnierczyk,P.<br>Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro<br>J Eur Acad Dermatol Venereol (2019) 33, 906-911. PubMed  Europe PubMed DOI  M
  52. [YEAR:1-11-2019]Ranjit,S., Wong,J.Y., Tan,J.W., Sin,T.C., Lee,J.M., Yin Han,W.K., Pojoga,L.H., Brooks,D.L., Garza,A.E., Maris,S.A., Katayama,I.A., Williams,J.S., Rivera,A., Adler,G.K., Williams,G.H. and Romero,J.R.<br>Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses<br>JCI Insight (1-11-2019) 4, e129615-e129615. PubMed  Europe PubMed
    53. 2018
  53. Aoki,K., Furuya,A., Matsumoto,K. and Tsujimoto,M.<br>The gene expression of two endoplasmic reticulum aminopeptidase 1 isoforms is regulated by distinct posttranscriptional mechanisms<br>Biochem Biophys Res Commun (2018) 503, 3180-3185. PubMed  Europe PubMed DOI  R
  54. Goto,Y., Ogawa,Y., Tsumoto,H., Miura,Y., Nakamura,T.J., Ogawa,K., Akimoto,Y., Kawakami,H., Endo,T., Yanoshita,R. and Tsujimoto,M.<br>Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation<br>Biochim Biophys Acta (2018) 1865, 874-888. PubMed  Europe PubMed DOI
  55. Papakyriakou,A., Reeves,E., Beton,M., Mikolajek,H., Douglas,L., Cooper,G., Elliott,T., Werner,J.M. and James,E.<br>The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1<br>J Biol Chem (2018) 293, 7538-7548. PubMed  Europe PubMed DOI
  56. [YEAR:20-8-2018]Pepelyayeva,Y., Rastall,D.P.W., Aldhamen,Y.A., O'Connell,P., Raehtz,S., Alyaqoub,F.S., Blake,M.K., Raedy,A.M., Angarita,A.M., Abbas,A.M., Pereira-Hicks,C.N., Roosa,S.G., McCabe,L. and Amalfitano,A.<br>ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis<br>Sci Rep (20-8-2018) 8, 12464-12464. PubMed  Europe PubMed
  57. Zhang,J., Yang,S.J., Gonzalez,F., Yang,J., Zhang,Y., He,M., Shastri,N. and Murthy,N.<br>A peptide-based fluorescent probe images ERAAP activity in cells and in high throughput assays<br>Chem Commun (Camb) (2018) 54, 7215-7218. PubMed  Europe PubMed DOI  L
    58. 2017
  58. Guasp,P., Barnea,E., Gonzalez-Escribano,M.F., Jimenez-Reinoso,A., Regueiro,J.R., Admon,A. and Lopez de Castro,J.A.<br>The Behcet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing<br>J Biol Chem (2017) 292, 9680-9689. PubMed  Europe PubMed DOI  M  P
  59. Romania,P., Cifaldi,L., Pignoloni,B., Starc,N., D'Alicandro,V., Melaiu,O., Pira,G.L., Giorda,E., Carrozzo,R., Bergvall,M., Bergstrom,T., Alfredsson,L., Olsson,T., Kockum,I., Seppala,I., Lehtimaki,T., Hurme,M.A., Hengel,H., Santoni,A., Cerboni,C., Locatelli,F., D'Amato,M. and Fruci,D.<br>Identification of a genetic variation in ERAP1 aminopeptidase that prevents human cytomegalovirus miR-UL112-5p-mediated immunoevasion<br>Cell Rep (2017) 20, 846-853. PubMed  Europe PubMed DOI  M
  60. Stamogiannos,A., Maben,Z., Papakyriakou,A., Mpakali,A., Kokkala,P., Georgiadis,D., Stern,L.J. and Stratikos,E.<br>Critical role of interdomain interactions in the conformational change and catalytic mechanism of endoplasmic reticulum aminopeptidase 1<br>Biochemistry (2017) 56, 1546-1558. PubMed  Europe PubMed DOI  I
  61. Wang,X., Ma,J., Ma,J., Wen,Y., Meng,L., Yang,H., Zhang,R. and Hao,D.<br>Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis<br>Mol Med Rep (2017) 16, 6532-6543. PubMed  Europe PubMed DOI  M
  62. Xu,S., Liu,H.W., Hu,X.X., Huan,S.Y., Zhang,J., Liu,Y.C., Yuan,L., Qu,F.L., Zhang,X.B. and Tan,W.<br>Visualization of endoplasmic reticulum aminopeptidase 1 under different redox conditions with a two-photon fluorescent probe<br>Anal Chem (2017) 89, 7641-7648. PubMed  Europe PubMed DOI  L
    63. 2016
  63. Chen,L., Ridley,A., Hammitzsch,A., Al-Mossawi,M.H., Bunting,H., Georgiadis,D., Chan,A., Kollnberger,S. and Bowness,P.<br>Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis<br>Ann Rheum Dis (2016) 75, 916-923. PubMed  Europe PubMed DOI  K
  64. Kokkala,P., Mpakali,A., Mauvais,F.X., Papakyriakou,A., Daskalaki,I., Petropoulou,I., Kavvalou,S., Papathanasopoulou,M., Agrotis,S., Fonsou,T.M., van Endert,P., Stratikos,E. and Georgiadis,D.<br>Optimization and structure-activity relationships of phosphinic pseudotripeptide inhibitors of aminopeptidases that generate antigenic peptides<br>J Med Chem (2016) 59, 9107-9123. PubMed  Europe PubMed DOI  I
  65. Pedersen,N.C., Dhanota,J.K. and Liu,H.<br>Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs<br>Vet Immunol Immunopathol (2016) 179, 46-57. PubMed  Europe PubMed DOI  M
  66. Sezgin,G., Dabak,R., Kaya,F.O., Kotevoglu,N., Uygur-Bayramicli,O. and Nalbant,S.<br>The association of endoplasmic reticulum aminopeptidase-1 (ERAP-1) with Familial Mediterranean Fever (FMF)<br>United European Gastroenterol J (2016) 4, 92-96. PubMed  Europe PubMed DOI  PMC  EPMC  M
  67. Stamogiannos,A., Papakyriakou,A., Mauvais,F.X., van Endert,P. and Stratikos,E.<br>Screening identifies thimerosal as a selective inhibitor of endoplasmic reticulum aminopeptidase 1<br>ACS Med Chem Lett (2016) 7, 681-685. PubMed  Europe PubMed DOI  PMC  EPMC  I
  68. Sui,L., Gandhi,A. and Guo,H.C.<br>Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1<br>Mol Immunol (2016) 80, 41-49. PubMed  Europe PubMed DOI  S
  69. Takeuchi,M., Ombrello,M.J., Kirino,Y., Erer,B., Tugal-Tutkun,I., Seyahi,E., Ozyazgan,Y., Watts,N.R., Gul,A., Kastner,D.L. and Remmers,E.F.<br>A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behcet's disease in HLA-B*51 carriers<br>Ann Rheum Dis (2016) 75, 2208-2211. PubMed  Europe PubMed DOI  M
    70. 2015
  70. Aldhamen,Y.A., Pepelyayeva,Y., Rastall,D.P., Seregin,S.S., Zervoudi,E., Koumantou,D., Aylsworth,C.F., Quiroga,D., Godbehere,S., Georgiadis,D., Stratikos,E. and Amalfitano,A.<br>Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells<br>J Innate Immun (2015) 7, 275-289. PubMed  Europe PubMed DOI  M
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