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Literature for peptidase M01.018: endoplasmic reticulum aminopeptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kang,J., Teplensky,M.H., Dittmar,J.W., Evangelopoulos,M., Hwang,J. and Mirkin,C.A.
    Controlling intracellular processing to enhance spherical nucleic acid immune stimulation
    Proc Natl Acad Sci U S A (2025) 122, e2409554122-e2409554122. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Su,S.H., Cai,X.Q., Li,Y.H., Xu,A.H., Huang,Q., Niu,H., You,Q.H. and Sun,G.Y.
    The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis
    BMC Infect Dis (2025) 25, 178-178. PubMed  Europe PubMed DOI  PMC  EPMC  M
    3. 2024
  3. Georgaki,G., Mpakali,A., Trakada,M., Papakyriakou,A. and Stratikos,E.
    Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties
    Front Immunol (2024) 15, 1415964-1415964. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Luo,Z., Huang,Y., Batra,N., Chen,Y., Huang,H., Wang,Y., Zhang,Z., Li,S., Chen,C.Y., Wang,Z., Sun,J., Wang,Q.J., Yang,D., Lu,B., Conway,J.F., Li,L.Y., Yu,A.M. and Li,S.
    Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy
    Nat Commun (2024) 15, 255-255. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Pande,S. and Guo,H.C.
    Structure-guided discovery of aminopeptidase ERAP1 variants capable of processing antigens with novel PC anchor specificities
    Immunology (2024) 171, 131-145. PubMed  Europe PubMed DOI
  6. Tiburca,L., Zaha,D.C., Jurca,M.C., Severin,E., Jurca,A. and Jurca,A.D.
    The Role of Aminopeptidase ERAP1 in Human Pathology-A Review
    Curr Issues Mol Biol (2024) 46, 1651-1667. PubMed  Europe PubMed DOI  PMC  EPMC  V
    7. 2023
  7. Abo El Nazar,S., Ghazy,A.A., Amer,I., Tawfik,S., Nassar,M. and Osman,E.M.
    Genetic polymorphisms of Endoplasmic reticulum amino peptidase 1 (ERAP1) and Interferon lambda 4 (IFN-lambda4) in Egyptian patients with type 1 diabetes mellitus
    Egypt J Immunol (2023) 30, 116-124. PubMed  Europe PubMed
  8. Evnouchidou,I., Koumantou,D., Nugue,M. and Saveanu,L.
    M1-aminopeptidase family - beyond antigen-trimming activities
    Curr Opin Immunol (2023) 83, 102337-102337. PubMed  Europe PubMed DOI  V
  9. Limanaqi,F., Vicentini,C., Saulle,I., Clerici,M. and Biasin,M.
    The role of endoplasmic reticulum aminopeptidases in type 1 diabetes mellitus
    Life Sci (2023) 323, 121701-121701. PubMed  Europe PubMed DOI  V
  10. Schmidt,K., Leisegang,M. and Kloetzel,P.M.
    ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes
    Mol Immunol (2023) 154, 61-68. PubMed  Europe PubMed DOI
  11. Tedeschi,V., Paldino,G., Alba,J., Molteni,E., Paladini,F., Scrivo,R., Congia,M., Cauli,A., Caccavale,R., Paroli,M., Di Franco,M., Tuosto,L., Sorrentino,R., D'Abramo,M. and Fiorillo,M.T.
    ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  M
  12. Temponeras,I., Samiotaki,M., Koumantou,D., Nikopaschou,M., Kuiper,J.J.W., Panayotou,G. and Stratikos,E.
    Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
    Eur J Immunol (2023) 53, e2350449-e2350449. PubMed  Europe PubMed DOI
    13. 2022
  13. Blake,M.K., O'Connell,P., Pepelyayeva,Y., Godbehere,S., Aldhamen,Y.A. and Amalfitano,A.
    ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses
    BMC Immunol (2022) 23, 9-9. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Cavers,A., Kugler,M.C., Ozguler,Y., Al-Obeidi,A.F., Hatemi,G., Ueberheide,B.M., Ucar,D., Manches,O. and Nowatzky,J.
    Behcet's disease risk-variant HLA-B51/ERAP1-Hap10 alters human CD8 T cell immunity
    Ann Rheum Dis (2022) 81, 1603-1611. PubMed  Europe PubMed DOI  PMC  EPMC  M
  15. Liu,H., Hu,B., Huang,J., Wang,Q., Wang,F., Pan,F. and Chen,L.
    Endoplasmic Reticulum Aminopeptidase 1 Is Involved in Anti-viral Immune Response of Hepatitis B Virus by Trimming Hepatitis B Core Antigen to Generate 9-Mers Peptides
    Front Microbiol (2022) 13, 829241-829241. PubMed  Europe PubMed DOI  PMC  EPMC  K
  16. Liu,S., Lu,J., Wu,J., Feng,D., Wang,Y., Su,X. and Cao,H.
    Structural and biochemical insights into the association between ERAP1 polymorphism and autoimmune diseases
    Biochem Biophys Res Commun (2022) 632, 189-194. PubMed  Europe PubMed DOI  V
  17. Martin-Esteban,A., Rodriguez,J.C., Peske,D., Lopez de Castro,J.A., Shastri,N. and Sadegh-Nasseri,S.
    The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
    Front Immunol (2022) 13, 1066483-1066483. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol (2022) 13, 1002375- PubMed  Europe PubMed
  19. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol (2022) 13, 1002375-1002375. PubMed  Europe PubMed DOI  PMC  EPMC  M
  20. [YEAR:19-11-2022]Müller,L., Burton,A.K., Tayler,C.L., Rowedder,J.E., Hutchinson,J.P., Peace,S., Quayle,J.M., Leveridge,M.V., Annan,R.S., Trost,M., Peltier-Heap,R.E. and Dueñas,M.E.
    A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1
    SLAS Discov (19-11-2022) , S2472-5552(22)13707-X-S2472-5552(22)13707-X. PubMed  Europe PubMed
  21. Niu,Y., Jiang,H., Yin,H., Wang,F., Hu,R., Hu,X., Peng,B., Shu,Y., Li,Z., Chen,S. and Guo,F.
    Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination
    Diabetes (2022) 71, 921-933. PubMed  Europe PubMed DOI  K
  22. Papakyriakou,A., Mpakali,A. and Stratikos,E.
    Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
    Front Immunol (2022) 13, 863529-863529. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Rahmawati,L.D., Soeroso,J. and Aryati
    The roles of Single Nucleotide Polymorphism (SNP) Endoplasmic Reticulum Aminopeptidase 1 (ERAP 1) gene in axial spondyloarthritis Indonesian adults
    Ann Med Surg (Lond) (2022) 77, 103675-103675. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2021
  24. D'Amico,S., Tempora,P., Lucarini,V., Melaiu,O., Gaspari,S., Algeri,M. and Fruci,D.
    ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19?
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
  25. Du,K., Sheng,L., Luo,X., Fan,G., Shen,D., Wu,C. and Shen,R.
    A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells
    Spectrochim Acta A Mol Biomol Spectrosc (2021) 249, 119328-119328. PubMed  Europe PubMed DOI
  26. Gelfman,S., Monnet,D., Ligocki,A.J., Tabary,T., Moscati,A., Bai,X., Freudenberg,J., Cooper,B., Kosmicki,J.A., Wolf,S., Ferreira,M.A.R., Overton,J., Weyne,J., Stahl,E.A., Baras,A., Romano,C., Cohen,J.H.M., Coppola,G. and Brezin,A.
    ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers
    Invest Ophthalmol Vis Sci (2021) 62, 3-3. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Hutchinson,J.P., Temponeras,I., Kuiper,J., Cortes,A., Korczynska,J., Kitchen,S. and Stratikos,E.
    Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties
    J Biol Chem (2021) , 100443-100443. PubMed  Europe PubMed DOI
  28. [YEAR:6-9-2021]Maben,Z., Arya,R., Georgiadis,D., Stratikos,E. and Stern,L.J.
    Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism
    Nat Commun (6-9-2021) 12, 5302-5302. PubMed  Europe PubMed
    29. 2020
  29. Chen,L., Shi,H., Koftori,D., Sekine,T., Nicastri,A., Ternette,N. and Bowness,P.
    Identification of an unconventional subpeptidome bound to the Behcet's disease-associated HLA-B*51:01 that is regulated by endoplasmic reticulum aminopeptidase 1 (ERAP1)
    Mol Cell Proteomics (2020) 19, 871-883. PubMed  Europe PubMed DOI
  30. Gao,S., Xu,T., Liang,W., Xun,C., Deng,Q., Guo,H. and Sheng,W.
    Association of rs27044 and rs30187 polymorphisms in endoplasmic reticulum aminopeptidase 1 gene and ankylosing spondylitis susceptibility: A meta-analysis
    Int J Rheum Dis (2020) 23, 499-510. PubMed  Europe PubMed DOI  M
  31. Joob,B. and Wiwanitkit,V.
    Endoplasmic reticulum aminopeptidase protein 1 and Behcet's syndrome
    Intern Emerg Med (2020) 15, 733-733. PubMed  Europe PubMed DOI  M
  32. Li,C., Li,Y., Yan,Z., Dai,S., Liu,S., Wang,X., Wang,J., Zhang,X., Shi,L. and Yao,Y.
    Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population
    BMC Cancer (2020) 20, 341-341. PubMed  Europe PubMed DOI  PMC  EPMC  M
  33. Liddle,J., Hutchinson,J.P., Kitchen,S., Rowland,P., Neu,M., Cecconie,T., Holmes,D.S., Jones,E., Korczynska,J., Koumantou,D., Lea,J.D., Nickels,L., Pemberton,M., Phillipou,A., Schneck,J.L., Sheehan,H., Tinworth,C.P., Uings,I., Wojno-Picon,J., Young,R.J. and Stratikos,E.
    Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation
    J Med Chem (2020) 63, 3348-3358. PubMed  Europe PubMed DOI
  34. Maben,Z., Arya,R., Rane,D., An,W.F., Metkar,S., Hickey,M., Bender,S., Ali,A., Nguyen,T.T., Evnouchidou,I., Schilling,R., Stratikos,E., Golden,J. and Stern,L.J.
    Discovery of selective inhibitors of endoplasmic reticulum aminopeptidase 1
    J Med Chem (2020) 63, 103-121. PubMed  Europe PubMed DOI  I
  35. Mavridis,G., Arya,R., Domnick,A., Zoidakis,J., Makridakis,M., Vlahou,A., Mpakali,A., Lelis,A., Georgiadis,D., Tampe,R., Papakyriakou,A., Stern,L.J. and Stratikos,E.
    A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1
    J Biol Chem (2020) 295, 7193-7210. PubMed  Europe PubMed DOI
  36. Niepieklo-Miniewska,W., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wisniewski,A., Piekarska,K., Nowak,I. and Kusnierczyk,P.
    Synergy of endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) polymorphisms in atopic dermatitis: Effects on disease prevalence
    Hum Immunol (2020) PubMed  Europe PubMed DOI
  37. Paladini,F., Fiorillo,M.T., Tedeschi,V., Mattorre,B. and Sorrentino,R.
    The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
    Front Immunol (2020) 11, 1576-1576. PubMed  Europe PubMed
  38. Textoris-Taube,K., Cammann,C., Henklein,P., Topfstedt,E., Ebstein,F., Henze,S., Liepe,J., Zhao,F., Schadendorf,D., Dahlmann,B., Uckert,W., Paschen,A., Mishto,M. and Seifert,U.
    ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope
    Eur J Immunol (2020) 50, 270-283. PubMed  Europe PubMed DOI
  39. Tsujimoto,M., Aoki,K., Ohnishi,A. and Goto,Y.
    Endoplasmic reticulum aminopeptidase 1 beyond antigenic peptide-processing enzyme in the endoplasmic reticulum
    Biol Pharm Bull (2020) 43, 207-214. PubMed  Europe PubMed DOI
  40. Vidal-Castineira,J.R., Lopez-Vazquez,A., Diaz-Bulnes,P., Diaz-Coto,S., Marquez-Kisinousky,L., Martinez-Borra,J., Navascues,C.A., Sanz-Cameno,P., de la Vega,J., Astudillo,A., Rodriguez,M. and Lopez-Larrea,C.
    Genetic contribution of endoplasmic reticulum aminopeptidase 1 polymorphisms to liver fibrosis progression in patients with HCV infection
    J Mol Med (Berl) (2020) 98, 1245-1254. PubMed  Europe PubMed DOI
  41. Zavattaro,E., Ramezani,M. and Sadeghi,M.
    Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: a systematic review and meta-analysis
    Gene (2020) 736, 144416-144416. PubMed  Europe PubMed DOI  M
  42. Zhang,S., Liu,S., Liu,N., Li,C., Wang,H., Shi,L., Zhang,X., Bao,L., Yao,Y. and Shi,L.
    Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese
    Front Genet (2020) 11, 566190-566190. PubMed  Europe PubMed
    43. 2019
  43. Georgiadis,D., Mpakali,A., Koumantou,D. and Stratikos,E.
    Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application
    Curr Med Chem (2019) 26, 2715-2729. PubMed  Europe PubMed DOI  I
  44. Giastas,P., Neu,M., Rowland,P. and Stratikos,E.
    High-resolution crystal structure of endoplasmic reticulum aminopeptidase 1 with bound phosphinic transition-state analogue inhibitor
    ACS Med Chem Lett (2019) 10, 708-713. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  45. Giastas,P., Mpakali,A., Papakyriakou,A., Lelis,A., Kokkala,P., Neu,M., Rowland,P., Liddle,J., Georgiadis,D. and Stratikos,E.
    Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
    Proc Natl Acad Sci U S A (2019) 116, 126709-26716. PubMed  Europe PubMed DOI  S
  46. Goto,Y., Nakamura,T.J., Ogawa,K., Hattori,A. and Tsujimoto,M.
    Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1
    J Biochem (2019) 165, 159-165. PubMed  Europe PubMed DOI  K
  47. Hanson,A.L., Morton,C.J., Parker,M.W., Bessette,D. and Kenna,T.J.
    The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease
    Hum Immunol (2019) 80, 281-289. PubMed  Europe PubMed DOI
  48. Koumantou,D., Barnea,E., Martin-Esteban,A., Maben,Z., Papakyriakou,A., Mpakali,A., Kokkala,P., Pratsinis,H., Georgiadis,D., Stern,L.J., Admon,A. and Stratikos,E.
    Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)
    Cancer Immunol Immunother (2019) 68, 1245-1261. PubMed  Europe PubMed DOI  I
  49. [YEAR:6-12-2019]Li,L., Batliwala,M. and Bouvier,M.
    ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation
    J Biol Chem (6-12-2019) 294, 18534-18544. PubMed  Europe PubMed
  50. Mpakali,A., Maben,Z., Stern,L.J. and Stratikos,E.
    Molecular pathways for antigenic peptide generation by ER aminopeptidase 1
    Mol Immunol (2019) 113, 50-57. PubMed  Europe PubMed DOI
  51. Niepieklo-Miniewska,W., Mpakali,A., Stratikos,E., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wilczynska,K., Nowak,I., Wisniewski,A., Zwolinska,K., Poninska,J., Ploski,R., Szepietowski,J.C. and Kusnierczyk,P.
    Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro
    J Eur Acad Dermatol Venereol (2019) 33, 906-911. PubMed  Europe PubMed DOI  M
  52. [YEAR:1-11-2019]Ranjit,S., Wong,J.Y., Tan,J.W., Sin,T.C., Lee,J.M., Yin Han,W.K., Pojoga,L.H., Brooks,D.L., Garza,A.E., Maris,S.A., Katayama,I.A., Williams,J.S., Rivera,A., Adler,G.K., Williams,G.H. and Romero,J.R.
    Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses
    JCI Insight (1-11-2019) 4, e129615-e129615. PubMed  Europe PubMed
    53. 2018
  53. Aoki,K., Furuya,A., Matsumoto,K. and Tsujimoto,M.
    The gene expression of two endoplasmic reticulum aminopeptidase 1 isoforms is regulated by distinct posttranscriptional mechanisms
    Biochem Biophys Res Commun (2018) 503, 3180-3185. PubMed  Europe PubMed DOI  R
  54. Goto,Y., Ogawa,Y., Tsumoto,H., Miura,Y., Nakamura,T.J., Ogawa,K., Akimoto,Y., Kawakami,H., Endo,T., Yanoshita,R. and Tsujimoto,M.
    Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation
    Biochim Biophys Acta (2018) 1865, 874-888. PubMed  Europe PubMed DOI
  55. Papakyriakou,A., Reeves,E., Beton,M., Mikolajek,H., Douglas,L., Cooper,G., Elliott,T., Werner,J.M. and James,E.
    The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1
    J Biol Chem (2018) 293, 7538-7548. PubMed  Europe PubMed DOI
  56. [YEAR:20-8-2018]Pepelyayeva,Y., Rastall,D.P.W., Aldhamen,Y.A., O'Connell,P., Raehtz,S., Alyaqoub,F.S., Blake,M.K., Raedy,A.M., Angarita,A.M., Abbas,A.M., Pereira-Hicks,C.N., Roosa,S.G., McCabe,L. and Amalfitano,A.
    ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis
    Sci Rep (20-8-2018) 8, 12464-12464. PubMed  Europe PubMed
  57. Zhang,J., Yang,S.J., Gonzalez,F., Yang,J., Zhang,Y., He,M., Shastri,N. and Murthy,N.
    A peptide-based fluorescent probe images ERAAP activity in cells and in high throughput assays
    Chem Commun (Camb) (2018) 54, 7215-7218. PubMed  Europe PubMed DOI  L
    58. 2017
  58. Guasp,P., Barnea,E., Gonzalez-Escribano,M.F., Jimenez-Reinoso,A., Regueiro,J.R., Admon,A. and Lopez de Castro,J.A.
    The Behcet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing
    J Biol Chem (2017) 292, 9680-9689. PubMed  Europe PubMed DOI  M  P
  59. Romania,P., Cifaldi,L., Pignoloni,B., Starc,N., D'Alicandro,V., Melaiu,O., Pira,G.L., Giorda,E., Carrozzo,R., Bergvall,M., Bergstrom,T., Alfredsson,L., Olsson,T., Kockum,I., Seppala,I., Lehtimaki,T., Hurme,M.A., Hengel,H., Santoni,A., Cerboni,C., Locatelli,F., D'Amato,M. and Fruci,D.
    Identification of a genetic variation in ERAP1 aminopeptidase that prevents human cytomegalovirus miR-UL112-5p-mediated immunoevasion
    Cell Rep (2017) 20, 846-853. PubMed  Europe PubMed DOI  M
  60. Stamogiannos,A., Maben,Z., Papakyriakou,A., Mpakali,A., Kokkala,P., Georgiadis,D., Stern,L.J. and Stratikos,E.
    Critical role of interdomain interactions in the conformational change and catalytic mechanism of endoplasmic reticulum aminopeptidase 1
    Biochemistry (2017) 56, 1546-1558. PubMed  Europe PubMed DOI  I
  61. Wang,X., Ma,J., Ma,J., Wen,Y., Meng,L., Yang,H., Zhang,R. and Hao,D.
    Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis
    Mol Med Rep (2017) 16, 6532-6543. PubMed  Europe PubMed DOI  M
  62. Xu,S., Liu,H.W., Hu,X.X., Huan,S.Y., Zhang,J., Liu,Y.C., Yuan,L., Qu,F.L., Zhang,X.B. and Tan,W.
    Visualization of endoplasmic reticulum aminopeptidase 1 under different redox conditions with a two-photon fluorescent probe
    Anal Chem (2017) 89, 7641-7648. PubMed  Europe PubMed DOI  L
    63. 2016
  63. Chen,L., Ridley,A., Hammitzsch,A., Al-Mossawi,M.H., Bunting,H., Georgiadis,D., Chan,A., Kollnberger,S. and Bowness,P.
    Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
    Ann Rheum Dis (2016) 75, 916-923. PubMed  Europe PubMed DOI  K
  64. Kokkala,P., Mpakali,A., Mauvais,F.X., Papakyriakou,A., Daskalaki,I., Petropoulou,I., Kavvalou,S., Papathanasopoulou,M., Agrotis,S., Fonsou,T.M., van Endert,P., Stratikos,E. and Georgiadis,D.
    Optimization and structure-activity relationships of phosphinic pseudotripeptide inhibitors of aminopeptidases that generate antigenic peptides
    J Med Chem (2016) 59, 9107-9123. PubMed  Europe PubMed DOI  I
  65. Pedersen,N.C., Dhanota,J.K. and Liu,H.
    Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs
    Vet Immunol Immunopathol (2016) 179, 46-57. PubMed  Europe PubMed DOI  M
  66. Sezgin,G., Dabak,R., Kaya,F.O., Kotevoglu,N., Uygur-Bayramicli,O. and Nalbant,S.
    The association of endoplasmic reticulum aminopeptidase-1 (ERAP-1) with Familial Mediterranean Fever (FMF)
    United European Gastroenterol J (2016) 4, 92-96. PubMed  Europe PubMed DOI  PMC  EPMC  M
  67. Stamogiannos,A., Papakyriakou,A., Mauvais,F.X., van Endert,P. and Stratikos,E.
    Screening identifies thimerosal as a selective inhibitor of endoplasmic reticulum aminopeptidase 1
    ACS Med Chem Lett (2016) 7, 681-685. PubMed  Europe PubMed DOI  PMC  EPMC  I
  68. Sui,L., Gandhi,A. and Guo,H.C.
    Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1
    Mol Immunol (2016) 80, 41-49. PubMed  Europe PubMed DOI  S
  69. Takeuchi,M., Ombrello,M.J., Kirino,Y., Erer,B., Tugal-Tutkun,I., Seyahi,E., Ozyazgan,Y., Watts,N.R., Gul,A., Kastner,D.L. and Remmers,E.F.
    A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behcet's disease in HLA-B*51 carriers
    Ann Rheum Dis (2016) 75, 2208-2211. PubMed  Europe PubMed DOI  M
    70. 2015
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