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Literature for peptidase C60.006: sortase A (Streptococcus-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Liu,J., Liu,R., Pan,H., Lu,J., Liu,Q. and Wang,G.<br>Luteolin Inhibits Invasion of Listeria monocytogenes by Interacting with SortaseA and InternalinB<br>Molecules (2026) 31 PubMed  Europe PubMed DOI  PMC  EPMC  I
  2. Lu,J., Liu,J., Zhou,H., Duan,Y., Wang,Z. and Wang,G.<br>Dryocrassin ABBA Inhibits the Function of LLO and SortaseA to Alleviate the Virulence of Listeria monocytogenes<br>J Microbiol Biotechnol (2026) 36, e2510021-e2510021. PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2025
  3. Avery,N.G., Tahti,E.F., Spiegel,P.C., Antos,J.M., McCarty,J. and Amacher,J.F.<br>A Putative Interaction between the Transmembrane Domains of Streptococcus pyogenes Sortase A and Its Endogenous Substrate M Protein Revealed by Molecular Dynamics Simulations<br>J Phys Chem B (2025) 129, 13117-13127. PubMed  Europe PubMed DOI
  4. Zhou,H., Yuan,Z., Guan,X.N., Yue,C., Wu,W., Lan,L., Gan,J., Zhang,T. and Yang,C.G.<br>Structure-based development of a covalent inhibitor targeting Streptococcus pyogenes over Staphylococcus aureus sortase A<br>Chemistry (2025) , e202500464-e202500464. PubMed  Europe PubMed DOI
  5. Zhou,Y., Huang,F. and Lin,H.<br>Berberine chloride hydrate impairs Streptococcus mutans biofilm formation via inhibiting sortase A activity<br>NPJ Biofilms Microbiomes (2025) 11, 120-120. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2024
  6. Hintzen,J.C.J., Abujubara,H., Tietze,D. and Tietze,A.<br>The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment<br>Chemistry (2024) , e202401103-e202401103. PubMed  Europe PubMed DOI  V
  7. Singh,S., Kumar,S. and Dhanasingh,I.<br>OVEREXPRESSION, PURIFICATION AND BIOCHEMICAL STUDIES OF SORTASE A FROM Enterococcus faecalis (Ef) AND ITS INHIBITION STUIDES WITH ALOENIN<br>Acta Trop (2024) , 107419-107419. PubMed  Europe PubMed DOI  I
  8. Wu,J., Chu,T., Hao,J. and Lin,L.<br>SpSrtA-Catalyzed Isopeptide Ligation on Lysine Residues<br>Microorganisms (2024) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2023
  9. Franco,E.M., Alves,L.A., Naveed,H., Freitas,V.A.A., Bastos,D.C. and Mattos-Graner,R.O.<br>Amyloid Fibrils Produced by Streptococcus sanguinis Contribute to Biofilm Formation and Immune Evasion<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Lou,F., Huang,H., Li,Y., Yang,S. and Shi,Y.<br>Investigation of the inhibitory effect and mechanism of epigallocatechin-3-gallate against Streptococcus suis sortase A<br>J Appl Microbiol (2023) 134 PubMed  Europe PubMed DOI  I
  11. Yadav,S., Parijat,P. and Krishnan,V.<br>Crystal structure of the pilus-specific sortase from early colonizing oral Streptococcus sanguinis captures an active open-lid conformation<br>Int J Biol Macromol (2023) 243, 125183-125183. PubMed  Europe PubMed DOI  I
    12. 2022
  12. Cho,E., Hwang,J.Y., Park,J.S., Oh,D., Oh,D.C., Park,H.G., Shin,J. and Oh,K.B.<br>Inhibition of Streptococcus mutans adhesion and biofilm formation with small-molecule inhibitors of sortase A from Juniperus chinensis<br>J Oral Microbiol (2022) 14, 2088937-2088937. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Guan,X.N., Zhang,T., Yang,T., Dong,Z., Yang,S., Lan,L., Gan,J. and Yang,C.G.<br>Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella<br>RSC Med Chem (2022) 13, 138-149. PubMed  Europe PubMed DOI  PMC  EPMC  I
  14. Johnson,D.A., Piper,I.M., Vogel,B.A., Jackson,S.N., Svendsen,J.E., Kodama,H.M., Lee,D.E., Lindblom,K.M., McCarty,J., Antos,J.M. and Amacher,J.F.<br>Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition<br>J Biol Chem (2022) 298, 102446-102446. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Kumar,V., Murmu,S. and Krishnan,V.<br>Deciphering the substrate specificity of housekeeping sortase A and pilus-specific sortase C of probiotic bacterium Lactococcus lactis<br>Biochimie (2022) 200, 140-152. PubMed  Europe PubMed DOI
  16. Readnour,B.M., Ayinuola,Y.A., Russo,B.T., Liang,Z., Lee,S.W., Ploplis,V.A., Fischetti,V.A. and Castellino,F.J.<br>Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation<br>J Biol Chem (2022) 298, 101940-101940. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2021
  17. Awussi,A.A., Roux,E., Humeau,C., Hafeez,Z., Maigret,B., Chang,O.K., Lecomte,X., Humbert,G., Miclo,L., Genay,M., Perrin,C. and Dary-Mourot,A.<br>Role of the Sortase A in the Release of Cell-Wall Proteinase PrtS in the Growth Medium of Streptococcus thermophilus 4F44<br>Microorganisms (2021) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  18. Zhang,H., Zhou,T., Su,L., Wang,H., Zhang,B. and Su,Y.<br>Effects of srtA variation on phagocytosis resistance and immune response of Streptococcus equi<br>Infect Genet Evol (2021) 89, 104732-104732. PubMed  Europe PubMed DOI
    19. 2020
  19. Biswas,T., Misra,A., Das,S., Yadav,P., Ramakumar,S. and Roy,R.<br>Interrogation of 3D-swapped structure and functional attributes of quintessential Sortase A from Streptococcus pneumoniae<br>Biochem J (2020) PubMed  Europe PubMed DOI
  20. Zou,Z., Noth,M., Jakob,F. and Schwaneberg,U.<br>Designed Streptococcus pyogenes Sortase A Accepts Branched Amines as Nucleophiles in Sortagging<br>Bioconjug Chem (2020) 31, 2476-2481. PubMed  Europe PubMed DOI
    21. 2019
  21. Wang,J., Shi,Y., Jing,S., Dong,H., Wang,D. and Wang,T.<br>Astilbin Inhibits the activity of sortase A from Streptococcus mutans<br>Molecules (2019) 24 PubMed  Europe PubMed DOI  I
    22. 2018
  22. Das,S., Srivastava,V.K., Parray,Z.A., Jyoti,A., Islam,A. and Kaushik,S.<br>Identification of potential inhibitors of sortase A: binding studies, in-silico docking and protein-protein interaction studies of sortase A from Enterococcus faecalis<br>Int J Biol Macromol (2018) 120, 1906-1916. PubMed  Europe PubMed DOI  I
    23. 2017
  23. Chen,F., Xie,F., Yang,B., Wang,C., Liu,S. and Zhang,Y.<br>Streptococcus suis sortase A is Ca2+ independent and is inhibited by acteoside, isoquercitrin and baicalin<br>PLoS ONE (2017) 12, e0173767-e0173767. PubMed  Europe PubMed DOI  I
    24. 2016
  24. Douillard,F.P., Rasinkangas,P., Bhattacharjee,A., Palva,A. and de Vos,W.M.<br>The N-terminal GYPSY motif is required for pilin-specific sortase SrtC1 functionality in Lactobacillus rhamnosus strain GG<br>PLoS ONE (2016) 11, e0153373-e0153373. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2015
  25. Chan,A.H., Yi,S.W., Terwilliger,A.L., Maresso,A.W., Jung,M.E. and Clubb,R.T.<br>Structure of the Bacillus anthracis sortase A enzyme bound to its sorting signal: a flexible amino-terminal appendage modulates substrate access<br>J Biol Chem (2015) 290, 25461-25474. PubMed  Europe PubMed DOI  S
  26. Rashidieh,B., Madani,Z., Azam,M.K., Maklavani,S.K., Akbari,N.R., Tavakoli,S. and Rigi,G.<br>Molecular docking based virtual screening of compounds for inhibiting sortase A in L.monocytogenes<br>Bioinformation (2015) 11, 501-505. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Yang,W.Y., Won,T.H., Ahn,C.H., Lee,S.H., Yang,H.C., Shin,J. and Oh,K.B.<br>Streptococcus mutans sortase A inhibitory metabolites from the flowers of Sophora japonica<br>Bioorg Med Chem Lett (2015) 25, 1394-1397. PubMed  Europe PubMed DOI  I
    28. 2014
  28. Douillard,F.P., Rasinkangas,P., von Ossowski,I., Reunanen,J., Palva,A. and de Vos,W.M.<br>Functional identification of conserved residues involved in Lactobacillus rhamnosus strain GG sortase specificity and pilus biogenesis<br>J Biol Chem (2014) 289, 15764-15775. PubMed  Europe PubMed DOI
    29. 2012
  29. Matsumoto,T., Takase,R., Tanaka,T., Fukuda,H. and Kondo,A.<br>Site-specific protein labeling with amine-containing molecules using Lactobacillus plantarum sortase<br>Biotechnol J (2012) 7, 642-648. PubMed  Europe PubMed DOI
  30. McCafferty,D.G. and Melvin,J.A.<br>Sortases<br>[ISSN:978-0-12-407743-0] (2012) 3, 2459-2465. DOI
  31. Munoz-Provencio,D., Rodriguez-Diaz,J., Collado,M.C., Langella,P., Bermudez-Humaran,L.G. and Monedero,V.<br>Functional analysis of the Lactobacillus casei BL23 sortases<br>Appl Environ Microbiol (2012) 78, 8684-8693. PubMed  Europe PubMed DOI
    32. 2011
  32. Aucher,W., Davison,S. and Fouet,A.<br>Characterization of the sortase repertoire in Bacillus anthracis<br>PLoS ONE (2011) 6, e27411-e27411. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Misra,A., Biswas,T., Das,S., Marathe,U., Sehgal,D., Roy,R.P. and Suryanarayanarao,R.<br>Crystallization and preliminary X-ray diffraction studies of sortase A from Streptococcus pneumoniae<br>Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 67, 1195-1198. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Necchi,F., Nardi-Dei,V., Biagini,M., Assfalg,M., Nuccitelli,A., Cozzi,R., Norais,N., Telford,J.L., Rinaudo,C.D., Grandi,G. and Maione,D.<br>Sortase A substrate specificity in GBS pilus 2a cell wall anchoring<br>PLoS ONE (2011) 6, e25300-e25300. PubMed  Europe PubMed DOI  PMC  EPMC  P
  35. Popp,M.W., Dougan,S.K., Chuang,T.Y., Spooner,E. and Ploegh,H.L.<br>Sortase-catalyzed transformations that improve the properties of cytokines<br>Proc Natl Acad Sci U S A (2011) 108, 3169-3174. PubMed  Europe PubMed DOI
  36. Tian,B. and Eriksson,L.A.<br>Structural changes of Listeria monocytogenes sortase A: a key to understanding the catalytic mechanism<br>Proteins (2011) 79, 1564-1572. PubMed  Europe PubMed DOI
    37. 2010
  37. Dieye,Y., Oxaran,V., Ledue-Clier,F., Alkhalaf,W., Buist,G., Juillard,V., Lee,C.W. and Piard,J.C.<br>Functionality of sortase A in Lactococcus lactis<br>Appl Environ Microbiol (2010) 76, 7332-7337. PubMed  Europe PubMed DOI
  38. Egan,S.A., Kurian,D., Ward,P.N., Hunt,L. and Leigh,J.A.<br>Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif<br>J Proteome Res (2010) 9, 1088-1095. PubMed  Europe PubMed DOI
  39. Khare,B., Samal,A., Vengadesan,K., Rajashankar,K.R., Ma,X., Huang,I.H., Ton-That,H. and Narayana,S.V.<br>Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1<br>Acta Crystallograph Sect F Struct Biol Cryst Commun (2010) 66, 1096-1100. PubMed  Europe PubMed DOI
  40. Weiner,E.M., Robson,S., Marohn,M. and Clubb,R.T.<br>The sortase A enzyme that attaches proteins to the cell wall of Bacillus anthracis contains an unusual active site architecture<br>J Biol Chem (2010) 285, 23433-23443. PubMed  Europe PubMed DOI  S
    41. 2009
  41. Nakata,M., Koller,T., Moritz,K., Ribardo,D., Jonas,L., McIver,K.S., Sumitomo,T., Terao,Y., Kawabata,S., Podbielski,A. and Kreikemeyer,B.<br>Mode of expression and functional characterization of FCT-3 pilus region-encoded proteins in Streptococcus pyogenes serotype M49<br>Infect Immun (2009) 77, 32-44. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Race,P.R., Bentley,M.L., Melvin,J.A., Crow,A., Hughes,R.K., Smith,W.D., Sessions,R.B., Kehoe,M.A., McCafferty,D.G. and Banfield,M.J.<br>Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism<br>J Biol Chem (2009) 284, 6924-6933. PubMed  Europe PubMed DOI  PMC  EPMC  S
  43. Wang,C., Li,M., Feng,Y., Zheng,F., Dong,Y., Pan,X., Cheng,G., Dong,R., Hu,D., Feng,X., Ge,J., Liu,D., Wang,J., Cao,M., Hu,F. and Tang,J.<br>The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2<br>Arch Microbiol (2009) 191, 23-33. PubMed  Europe PubMed DOI
    44. 2008
  44. LeMieux,J., Woody,S. and Camilli,A.<br>Roles of the sortases of Streptococcus pneumoniae in assembly of the RlrA pilus<br>J Bacteriol (2008) 190, 6002-6013. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2007
  45. Kemp,K.D., Singh,K.V., Nallapareddy,S.R. and Murray,B.E.<br>Relative contributions of Enterococcus faecalis OG1RF sortase-encoding genes, srtA and bps (srtC), to biofilm formation and a murine model of urinary tract infection<br>Infect Immun (2007) 75, 5399-5404. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Nobbs,A.H., Vajna,R.M., Johnson,J.R., Zhang,Y., Erlandsen,S.L., Oli,M.W., Kreth,J., Brady,L.J. and Herzberg,M.C.<br>Consequences of a sortase A mutation in Streptococcus gordonii<br>Microbiology (Reading) (2007) 153, 4088-4097. PubMed  Europe PubMed DOI
    47. 2006
  47. [YEAR:21-9-2006]Paterson,G.K. and Mitchell,T.J.<br>The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis<br>Microbes Infect (21-9-2006) 8, 145-153. PubMed  Europe PubMed DOI
  48. [YEAR:14-9-2006]Yamaguchi,M., Terao,Y., Ogawa,T., Takahashi,T., Hamada,S. and Kawabata,S.<br>Role of Streptococcus sanguinis sortase A in bacterial colonization<br>Microbes Infect (14-9-2006) 8, 2791-2796. PubMed  Europe PubMed DOI
    49. 2005
  49. Lalioui,L., Pellegrini,E., Dramsi,S., Baptista,M., Bourgeois,N., Doucet-Populaire,F., Rusniok,C., Zouine,M., Glaser,P., Kunst,F., Poyart,C. and Trieu-Cuot,P.<br>The SrtA sortase of Streptococcus agalactiae is required for cell wall anchoring of proteins containing the LPXTG motif, for adhesion to epithelial cells, and for colonization of the mouse intestine<br>Infect Immun (2005) 73, 3342-3350. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Zink,S.D. and Burns,D.L.<br>Importance of srtA and srtB for growth of Bacillus anthracis in macrophages<br>Infect Immun (2005) 73, 5222-5228. PubMed  Europe PubMed DOI  PMC  EPMC
    51. 2004
  51. Comfort,D. and Clubb,R.T.<br>A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria<br>Infect Immun (2004) 72, 2710-2722. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Igarashi,T.<br>Deletion in sortase gene of Streptococcus mutans Ingbritt<br>Oral Microbiol Immunol (2004) 19, 210-213. PubMed  Europe PubMed DOI
  53. Igarashi,T., Asaga,E., Sato,Y. and Goto,N.<br>Inactivation of srtA gene of Streptococcus mutans inhibits dextran-dependent aggregation by glucan-binding protein C<br>Oral Microbiol Immunol (2004) 19, 57-60. PubMed  Europe PubMed DOI
  54. Igarashi,T., Asaga,E. and Goto,N.<br>Roles of Streptococcus mutans dextranase anchored to the cell wall by sortase<br>Oral Microbiol Immunol (2004) 19, 102-105. PubMed  Europe PubMed DOI
    55. 2003
  55. Igarashi,T., Asaga,E. and Goto,N.<br>The sortase of Streptococcus mutans mediates cell wall anchoring of a surface protein antigen<br>Oral Microbiol Immunol (2003) 18, 266-269. PubMed  Europe PubMed DOI
  56. Kharat,A.S. and Tomasz,A.<br>Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro<br>Infect Immun (2003) 71, 2758-2765. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Lee,S.F. and Boran,T.L.<br>Roles of sortase in surface expression of the major protein adhesin P1, saliva-induced aggregation and adherence, and cariogenicity of Streptococcus mutans<br>Infect Immun (2003) 71, 676-681. PubMed  Europe PubMed DOI  PMC  EPMC
  58. [YEAR:28-2-2003]Osaki,M., Takamatsu,D., Shimoji,Y. and Sekizaki,T.<br>Allelic variation in srtAs of Streptococcus suis strains<br>FEMS Microbiol Lett (28-2-2003) 219, 195-201. PubMed  Europe PubMed DOI
    59. 2002
  59. Barnett,T.C. and Scott,J.R.<br>Differential recognition of surface proteins in Streptococcus pyogenes by two sortase gene homologs<br>J Bacteriol (2002) 184, 2181-2191. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Bierne,H., Mazmanian,S.K., Trost,M., Pucciarelli,M.G., Liu,G., Dehoux,P., Jansch,L., Garcia-del Portillo,F., Schneewind,O. and Cossart,P.<br>Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence<br>Mol Microbiol (2002) 43, 869-881. PubMed  Europe PubMed DOI
  61. Garandeau,C., Reglier-Poupet,H., Dubail,I., Beretti,J.L., Berche,P. and Charbit,A.<br>The sortase SrtA of Listeria monocytogenes is involved in processing of internalin and in virulence<br>Infect Immun (2002) 70, 1382-1390. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Osaki,M., Takamatsu,D., Shimoji,Y. and Sekizaki,T.<br>Characterization of Streptococcus suis genes encoding proteins homologous to sortase of gram-positive bacteria<br>J Bacteriol (2002) 184, 971-982. PubMed  Europe PubMed DOI  PMC  EPMC
    63. 2001
  63. Bolken,T.C., Franke,C.A., Jones,K.F., Zeller,G.O., Jones,C.H., Dutton,E.K. and Hruby,D.E.<br>Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion<br>Infect Immun (2001) 69, 75-80. PubMed  Europe PubMed DOI  PMC  EPMC

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