Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C60.006: sortase A (Streptococcus-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Liu,J., Liu,R., Pan,H., Lu,J., Liu,Q. and Wang,G.
    Luteolin Inhibits Invasion of Listeria monocytogenes by Interacting with SortaseA and InternalinB
    Molecules (2026) 31 PubMed  Europe PubMed DOI  PMC  EPMC  I
  2. Lu,J., Liu,J., Zhou,H., Duan,Y., Wang,Z. and Wang,G.
    Dryocrassin ABBA Inhibits the Function of LLO and SortaseA to Alleviate the Virulence of Listeria monocytogenes
    J Microbiol Biotechnol (2026) 36, e2510021-e2510021. PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2025
  3. Avery,N.G., Tahti,E.F., Spiegel,P.C., Antos,J.M., McCarty,J. and Amacher,J.F.
    A Putative Interaction between the Transmembrane Domains of Streptococcus pyogenes Sortase A and Its Endogenous Substrate M Protein Revealed by Molecular Dynamics Simulations
    J Phys Chem B (2025) 129, 13117-13127. PubMed  Europe PubMed DOI
  4. Zhou,H., Yuan,Z., Guan,X.N., Yue,C., Wu,W., Lan,L., Gan,J., Zhang,T. and Yang,C.G.
    Structure-based development of a covalent inhibitor targeting Streptococcus pyogenes over Staphylococcus aureus sortase A
    Chemistry (2025) , e202500464-e202500464. PubMed  Europe PubMed DOI
  5. Zhou,Y., Huang,F. and Lin,H.
    Berberine chloride hydrate impairs Streptococcus mutans biofilm formation via inhibiting sortase A activity
    NPJ Biofilms Microbiomes (2025) 11, 120-120. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2024
  6. Hintzen,J.C.J., Abujubara,H., Tietze,D. and Tietze,A.
    The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment
    Chemistry (2024) , e202401103-e202401103. PubMed  Europe PubMed DOI  V
  7. Singh,S., Kumar,S. and Dhanasingh,I.
    OVEREXPRESSION, PURIFICATION AND BIOCHEMICAL STUDIES OF SORTASE A FROM Enterococcus faecalis (Ef) AND ITS INHIBITION STUIDES WITH ALOENIN
    Acta Trop (2024) , 107419-107419. PubMed  Europe PubMed DOI  I
  8. Wu,J., Chu,T., Hao,J. and Lin,L.
    SpSrtA-Catalyzed Isopeptide Ligation on Lysine Residues
    Microorganisms (2024) 12 PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2023
  9. Franco,E.M., Alves,L.A., Naveed,H., Freitas,V.A.A., Bastos,D.C. and Mattos-Graner,R.O.
    Amyloid Fibrils Produced by Streptococcus sanguinis Contribute to Biofilm Formation and Immune Evasion
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Lou,F., Huang,H., Li,Y., Yang,S. and Shi,Y.
    Investigation of the inhibitory effect and mechanism of epigallocatechin-3-gallate against Streptococcus suis sortase A
    J Appl Microbiol (2023) 134 PubMed  Europe PubMed DOI  I
  11. Yadav,S., Parijat,P. and Krishnan,V.
    Crystal structure of the pilus-specific sortase from early colonizing oral Streptococcus sanguinis captures an active open-lid conformation
    Int J Biol Macromol (2023) 243, 125183-125183. PubMed  Europe PubMed DOI  I
    12. 2022
  12. Cho,E., Hwang,J.Y., Park,J.S., Oh,D., Oh,D.C., Park,H.G., Shin,J. and Oh,K.B.
    Inhibition of Streptococcus mutans adhesion and biofilm formation with small-molecule inhibitors of sortase A from Juniperus chinensis
    J Oral Microbiol (2022) 14, 2088937-2088937. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Guan,X.N., Zhang,T., Yang,T., Dong,Z., Yang,S., Lan,L., Gan,J. and Yang,C.G.
    Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella
    RSC Med Chem (2022) 13, 138-149. PubMed  Europe PubMed DOI  PMC  EPMC  I
  14. Johnson,D.A., Piper,I.M., Vogel,B.A., Jackson,S.N., Svendsen,J.E., Kodama,H.M., Lee,D.E., Lindblom,K.M., McCarty,J., Antos,J.M. and Amacher,J.F.
    Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition
    J Biol Chem (2022) 298, 102446-102446. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Kumar,V., Murmu,S. and Krishnan,V.
    Deciphering the substrate specificity of housekeeping sortase A and pilus-specific sortase C of probiotic bacterium Lactococcus lactis
    Biochimie (2022) 200, 140-152. PubMed  Europe PubMed DOI
  16. Readnour,B.M., Ayinuola,Y.A., Russo,B.T., Liang,Z., Lee,S.W., Ploplis,V.A., Fischetti,V.A. and Castellino,F.J.
    Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation
    J Biol Chem (2022) 298, 101940-101940. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2021
  17. Awussi,A.A., Roux,E., Humeau,C., Hafeez,Z., Maigret,B., Chang,O.K., Lecomte,X., Humbert,G., Miclo,L., Genay,M., Perrin,C. and Dary-Mourot,A.
    Role of the Sortase A in the Release of Cell-Wall Proteinase PrtS in the Growth Medium of Streptococcus thermophilus 4F44
    Microorganisms (2021) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  18. Zhang,H., Zhou,T., Su,L., Wang,H., Zhang,B. and Su,Y.
    Effects of srtA variation on phagocytosis resistance and immune response of Streptococcus equi
    Infect Genet Evol (2021) 89, 104732-104732. PubMed  Europe PubMed DOI
    19. 2020
  19. Biswas,T., Misra,A., Das,S., Yadav,P., Ramakumar,S. and Roy,R.
    Interrogation of 3D-swapped structure and functional attributes of quintessential Sortase A from Streptococcus pneumoniae
    Biochem J (2020) PubMed  Europe PubMed DOI
  20. Zou,Z., Noth,M., Jakob,F. and Schwaneberg,U.
    Designed Streptococcus pyogenes Sortase A Accepts Branched Amines as Nucleophiles in Sortagging
    Bioconjug Chem (2020) 31, 2476-2481. PubMed  Europe PubMed DOI
    21. 2019
  21. Wang,J., Shi,Y., Jing,S., Dong,H., Wang,D. and Wang,T.
    Astilbin Inhibits the activity of sortase A from Streptococcus mutans
    Molecules (2019) 24 PubMed  Europe PubMed DOI  I
    22. 2018
  22. Das,S., Srivastava,V.K., Parray,Z.A., Jyoti,A., Islam,A. and Kaushik,S.
    Identification of potential inhibitors of sortase A: binding studies, in-silico docking and protein-protein interaction studies of sortase A from Enterococcus faecalis
    Int J Biol Macromol (2018) 120, 1906-1916. PubMed  Europe PubMed DOI  I
    23. 2017
  23. Chen,F., Xie,F., Yang,B., Wang,C., Liu,S. and Zhang,Y.
    Streptococcus suis sortase A is Ca2+ independent and is inhibited by acteoside, isoquercitrin and baicalin
    PLoS ONE (2017) 12, e0173767-e0173767. PubMed  Europe PubMed DOI  I
    24. 2016
  24. Douillard,F.P., Rasinkangas,P., Bhattacharjee,A., Palva,A. and de Vos,W.M.
    The N-terminal GYPSY motif is required for pilin-specific sortase SrtC1 functionality in Lactobacillus rhamnosus strain GG
    PLoS ONE (2016) 11, e0153373-e0153373. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2015
  25. Chan,A.H., Yi,S.W., Terwilliger,A.L., Maresso,A.W., Jung,M.E. and Clubb,R.T.
    Structure of the Bacillus anthracis sortase A enzyme bound to its sorting signal: a flexible amino-terminal appendage modulates substrate access
    J Biol Chem (2015) 290, 25461-25474. PubMed  Europe PubMed DOI  S
  26. Rashidieh,B., Madani,Z., Azam,M.K., Maklavani,S.K., Akbari,N.R., Tavakoli,S. and Rigi,G.
    Molecular docking based virtual screening of compounds for inhibiting sortase A in L.monocytogenes
    Bioinformation (2015) 11, 501-505. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Yang,W.Y., Won,T.H., Ahn,C.H., Lee,S.H., Yang,H.C., Shin,J. and Oh,K.B.
    Streptococcus mutans sortase A inhibitory metabolites from the flowers of Sophora japonica
    Bioorg Med Chem Lett (2015) 25, 1394-1397. PubMed  Europe PubMed DOI  I
    28. 2014
  28. Douillard,F.P., Rasinkangas,P., von Ossowski,I., Reunanen,J., Palva,A. and de Vos,W.M.
    Functional identification of conserved residues involved in Lactobacillus rhamnosus strain GG sortase specificity and pilus biogenesis
    J Biol Chem (2014) 289, 15764-15775. PubMed  Europe PubMed DOI
    29. 2012
  29. Matsumoto,T., Takase,R., Tanaka,T., Fukuda,H. and Kondo,A.
    Site-specific protein labeling with amine-containing molecules using Lactobacillus plantarum sortase
    Biotechnol J (2012) 7, 642-648. PubMed  Europe PubMed DOI
  30. McCafferty,D.G. and Melvin,J.A.
    Sortases
    [ISSN:978-0-12-407743-0] (2012) 3, 2459-2465. DOI
  31. Munoz-Provencio,D., Rodriguez-Diaz,J., Collado,M.C., Langella,P., Bermudez-Humaran,L.G. and Monedero,V.
    Functional analysis of the Lactobacillus casei BL23 sortases
    Appl Environ Microbiol (2012) 78, 8684-8693. PubMed  Europe PubMed DOI
    32. 2011
  32. Aucher,W., Davison,S. and Fouet,A.
    Characterization of the sortase repertoire in Bacillus anthracis
    PLoS ONE (2011) 6, e27411-e27411. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Misra,A., Biswas,T., Das,S., Marathe,U., Sehgal,D., Roy,R.P. and Suryanarayanarao,R.
    Crystallization and preliminary X-ray diffraction studies of sortase A from Streptococcus pneumoniae
    Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 67, 1195-1198. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Necchi,F., Nardi-Dei,V., Biagini,M., Assfalg,M., Nuccitelli,A., Cozzi,R., Norais,N., Telford,J.L., Rinaudo,C.D., Grandi,G. and Maione,D.
    Sortase A substrate specificity in GBS pilus 2a cell wall anchoring
    PLoS ONE (2011) 6, e25300-e25300. PubMed  Europe PubMed DOI  PMC  EPMC  P
  35. Popp,M.W., Dougan,S.K., Chuang,T.Y., Spooner,E. and Ploegh,H.L.
    Sortase-catalyzed transformations that improve the properties of cytokines
    Proc Natl Acad Sci U S A (2011) 108, 3169-3174. PubMed  Europe PubMed DOI
  36. Tian,B. and Eriksson,L.A.
    Structural changes of Listeria monocytogenes sortase A: a key to understanding the catalytic mechanism
    Proteins (2011) 79, 1564-1572. PubMed  Europe PubMed DOI
    37. 2010
  37. Dieye,Y., Oxaran,V., Ledue-Clier,F., Alkhalaf,W., Buist,G., Juillard,V., Lee,C.W. and Piard,J.C.
    Functionality of sortase A in Lactococcus lactis
    Appl Environ Microbiol (2010) 76, 7332-7337. PubMed  Europe PubMed DOI
  38. Egan,S.A., Kurian,D., Ward,P.N., Hunt,L. and Leigh,J.A.
    Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif
    J Proteome Res (2010) 9, 1088-1095. PubMed  Europe PubMed DOI
  39. Khare,B., Samal,A., Vengadesan,K., Rajashankar,K.R., Ma,X., Huang,I.H., Ton-That,H. and Narayana,S.V.
    Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1
    Acta Crystallograph Sect F Struct Biol Cryst Commun (2010) 66, 1096-1100. PubMed  Europe PubMed DOI
  40. Weiner,E.M., Robson,S., Marohn,M. and Clubb,R.T.
    The sortase A enzyme that attaches proteins to the cell wall of Bacillus anthracis contains an unusual active site architecture
    J Biol Chem (2010) 285, 23433-23443. PubMed  Europe PubMed DOI  S
    41. 2009
  41. Nakata,M., Koller,T., Moritz,K., Ribardo,D., Jonas,L., McIver,K.S., Sumitomo,T., Terao,Y., Kawabata,S., Podbielski,A. and Kreikemeyer,B.
    Mode of expression and functional characterization of FCT-3 pilus region-encoded proteins in Streptococcus pyogenes serotype M49
    Infect Immun (2009) 77, 32-44. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Race,P.R., Bentley,M.L., Melvin,J.A., Crow,A., Hughes,R.K., Smith,W.D., Sessions,R.B., Kehoe,M.A., McCafferty,D.G. and Banfield,M.J.
    Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism
    J Biol Chem (2009) 284, 6924-6933. PubMed  Europe PubMed DOI  PMC  EPMC  S
  43. Wang,C., Li,M., Feng,Y., Zheng,F., Dong,Y., Pan,X., Cheng,G., Dong,R., Hu,D., Feng,X., Ge,J., Liu,D., Wang,J., Cao,M., Hu,F. and Tang,J.
    The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2
    Arch Microbiol (2009) 191, 23-33. PubMed  Europe PubMed DOI
    44. 2008
  44. LeMieux,J., Woody,S. and Camilli,A.
    Roles of the sortases of Streptococcus pneumoniae in assembly of the RlrA pilus
    J Bacteriol (2008) 190, 6002-6013. PubMed  Europe PubMed DOI  PMC  EPMC
    45. 2007
  45. Kemp,K.D., Singh,K.V., Nallapareddy,S.R. and Murray,B.E.
    Relative contributions of Enterococcus faecalis OG1RF sortase-encoding genes, srtA and bps (srtC), to biofilm formation and a murine model of urinary tract infection
    Infect Immun (2007) 75, 5399-5404. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Nobbs,A.H., Vajna,R.M., Johnson,J.R., Zhang,Y., Erlandsen,S.L., Oli,M.W., Kreth,J., Brady,L.J. and Herzberg,M.C.
    Consequences of a sortase A mutation in Streptococcus gordonii
    Microbiology (Reading) (2007) 153, 4088-4097. PubMed  Europe PubMed DOI
    47. 2006
  47. [YEAR:21-9-2006]Paterson,G.K. and Mitchell,T.J.
    The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis
    Microbes Infect (21-9-2006) 8, 145-153. PubMed  Europe PubMed DOI
  48. [YEAR:14-9-2006]Yamaguchi,M., Terao,Y., Ogawa,T., Takahashi,T., Hamada,S. and Kawabata,S.
    Role of Streptococcus sanguinis sortase A in bacterial colonization
    Microbes Infect (14-9-2006) 8, 2791-2796. PubMed  Europe PubMed DOI
    49. 2005
  49. Lalioui,L., Pellegrini,E., Dramsi,S., Baptista,M., Bourgeois,N., Doucet-Populaire,F., Rusniok,C., Zouine,M., Glaser,P., Kunst,F., Poyart,C. and Trieu-Cuot,P.
    The SrtA sortase of Streptococcus agalactiae is required for cell wall anchoring of proteins containing the LPXTG motif, for adhesion to epithelial cells, and for colonization of the mouse intestine
    Infect Immun (2005) 73, 3342-3350. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Zink,S.D. and Burns,D.L.
    Importance of srtA and srtB for growth of Bacillus anthracis in macrophages
    Infect Immun (2005) 73, 5222-5228. PubMed  Europe PubMed DOI  PMC  EPMC
    51. 2004
  51. Comfort,D. and Clubb,R.T.
    A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria
    Infect Immun (2004) 72, 2710-2722. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Igarashi,T.
    Deletion in sortase gene of Streptococcus mutans Ingbritt
    Oral Microbiol Immunol (2004) 19, 210-213. PubMed  Europe PubMed DOI
  53. Igarashi,T., Asaga,E., Sato,Y. and Goto,N.
    Inactivation of srtA gene of Streptococcus mutans inhibits dextran-dependent aggregation by glucan-binding protein C
    Oral Microbiol Immunol (2004) 19, 57-60. PubMed  Europe PubMed DOI
  54. Igarashi,T., Asaga,E. and Goto,N.
    Roles of Streptococcus mutans dextranase anchored to the cell wall by sortase
    Oral Microbiol Immunol (2004) 19, 102-105. PubMed  Europe PubMed DOI
    55. 2003
  55. Igarashi,T., Asaga,E. and Goto,N.
    The sortase of Streptococcus mutans mediates cell wall anchoring of a surface protein antigen
    Oral Microbiol Immunol (2003) 18, 266-269. PubMed  Europe PubMed DOI
  56. Kharat,A.S. and Tomasz,A.
    Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro
    Infect Immun (2003) 71, 2758-2765. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Lee,S.F. and Boran,T.L.
    Roles of sortase in surface expression of the major protein adhesin P1, saliva-induced aggregation and adherence, and cariogenicity of Streptococcus mutans
    Infect Immun (2003) 71, 676-681. PubMed  Europe PubMed DOI  PMC  EPMC
  58. [YEAR:28-2-2003]Osaki,M., Takamatsu,D., Shimoji,Y. and Sekizaki,T.
    Allelic variation in srtAs of Streptococcus suis strains
    FEMS Microbiol Lett (28-2-2003) 219, 195-201. PubMed  Europe PubMed DOI
    59. 2002
  59. Barnett,T.C. and Scott,J.R.
    Differential recognition of surface proteins in Streptococcus pyogenes by two sortase gene homologs
    J Bacteriol (2002) 184, 2181-2191. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Bierne,H., Mazmanian,S.K., Trost,M., Pucciarelli,M.G., Liu,G., Dehoux,P., Jansch,L., Garcia-del Portillo,F., Schneewind,O. and Cossart,P.
    Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Mol Microbiol (2002) 43, 869-881. PubMed  Europe PubMed DOI
  61. Garandeau,C., Reglier-Poupet,H., Dubail,I., Beretti,J.L., Berche,P. and Charbit,A.
    The sortase SrtA of Listeria monocytogenes is involved in processing of internalin and in virulence
    Infect Immun (2002) 70, 1382-1390. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Osaki,M., Takamatsu,D., Shimoji,Y. and Sekizaki,T.
    Characterization of Streptococcus suis genes encoding proteins homologous to sortase of gram-positive bacteria
    J Bacteriol (2002) 184, 971-982. PubMed  Europe PubMed DOI  PMC  EPMC
    63. 2001
  63. Bolken,T.C., Franke,C.A., Jones,K.F., Zeller,G.O., Jones,C.H., Dutton,E.K. and Hruby,D.E.
    Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion
    Infect Immun (2001) 69, 75-80. PubMed  Europe PubMed DOI  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use