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Literature for peptidase C56.002: DJ-1 putative peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Alipour,M., Hajipour-Verdom,B., Zali,A., Ashrafi,F., Abdolmaleki,P., Oraee-Yazdani,S., Akhlaghdoust,M. and Karimi,N.
    Interaction of alpha-synuclein with DJ-1 in homodimer and L166P mutant monomer forms in Parkinson's disease: a molecular dynamics study
    J Biomol Struct Dyn (2025) , 1-8. PubMed  Europe PubMed DOI
  2. Alshammari,Q.A.
    Redox modulatory role of DJ-1 in Parkinson's disease
    Biogerontology (2025) 26, 81-81. PubMed  Europe PubMed DOI  V
  3. Chen,Y., Hu,X., Dou,J., Chen,L. and Zhu,L.
    DJ-1 protein ameliorates nonalcoholic fatty liver disease via ER-stress pathway and reduces inflammation
    Biochem Biophys Res Commun (2025) 776, 152175-152175. PubMed  Europe PubMed DOI
  4. Dash,B.K., Urano,Y., Mita,Y., Ashida,Y., Hirose,R. and Noguchi,N.
    Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex
    Proc Natl Acad Sci U S A (2025) 122, e2414790122-e2414790122. PubMed  Europe PubMed DOI
  5. Heineman,A., Linck,J., Eylon,A. and Parmar,M.S.
    Challenges and Opportunities of Early Parkinson's Disease Biomarkers: alpha-Synuclein, Leucine-Rich Repeat Kinase 2 (LRRK2), DJ-1, and microRNAs
    Cureus (2025) 17, e91510-e91510. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Jiang,M., Wang,M., Wan,L., Li,S., Sun,C., Cao,H., Yu,C. and Lin,J.
    Inhibition of DJ-1 protects from lupus onset and severity
    Sci Rep (2025) 15, 31217-31217. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Li,H., Ritsema,Y., Lin,Z., Symasek,A., Wang,Q., Ma,X., Yuan,C. and Zheng,Q.
    Sirtuin 2 Regulates Histone Glycation as a Semi-deglycase
    Biochemistry (2025) PubMed  Europe PubMed DOI
  8. Mathas,N., Braud,E., Galardon,E., Larigot,L., Etheve-Quelquejeu,M., Sari,M.A., LE Grand,B., Blanc,E.B., Coumoul,X. and Dairou,J.
    Park7 (DJ-1), a Parkinson-associated glyoxalase/deglycase: characterization of enzymatic activity in biological samples using fluorescence-based liquid chromatography
    Biochimie (2025) 235, 113-121. PubMed  Europe PubMed DOI
  9. Wang,H., Guo,Y.M., Yang,J.R., Cao,C., Ren,J.N., Ye,H.Y. and Chen,J.Z.
    Mechanistic Investigation of Cysteine-Targeted Covalent Inhibition of DJ-1 via MD, QM/MM, and SAPT Computations
    J Chem Inf Model (2025) PubMed  Europe PubMed DOI
  10. Zhao,A., Ding,Y., Zhong,M., Niu,M., Wang,L., Jiao,Y., Liu,J. and Li,Y.
    Neuronal DJ-1 regulates microglial activation in Parkinson's disease
    Neural Regen Res (2025) PubMed  Europe PubMed DOI  K
  11. Zhou,F., Zhou,J.B., Wei,T.P., Wu,D. and Wang,R.X.
    DJ-1 Serves as a Central Regulator of Diabetes Complications
    Curr Issues Mol Biol (2025) 47 PubMed  Europe PubMed DOI  PMC  EPMC  V
    12. 2024
  12. Akhmadi,A., Yeskendir,A., Dey,N., Mussakhmetov,A., Shatkenova,Z., Kulyyassov,A., Andreeva,A. and Utepbergenov,D.
    DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
    Nat Commun (2024) 15, 2004-2004. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Bekmagambetov,A., Shkraba,E., Yeskendir,A., Akhmadi,A. and Utepbergenov,D.
    cPGA hydrolase assay of DJ-1 in crude cell lysates: Implications for sensing of oxidative stress
    Anal Biochem (2024) 694, 115631-115631. PubMed  Europe PubMed DOI
  14. Dhinesh Kumar,M., Karthikeyan,M., Kaniraja,G., Muthukumar,K., Muneeswaran,G. and Karunakaran,C.
    Computational modelling and optimization studies of electropentamer for molecular imprinting of DJ-1
    J Mol Graph Model (2024) 128, 108715-108715. PubMed  Europe PubMed DOI
  15. Ji,Y.W., Wen,X.Y., Tang,H.P., Jin,Z.S., Su,W.T., Zhou,L., Xia,Z.Y., Xia,Z.Y. and Lei,S.Q.
    DJ-1: Potential target for treatment of myocardial ischemia-reperfusion injury
    Biomed Pharmacother (2024) 179, 117383-117383. PubMed  Europe PubMed DOI  V
  16. Jia,Y., Oyken,M., Kim,R.Q., Tjokrodirijo,R.T.N., de Ru,A.H., Janssen,A.P.A., Hacker,S.M., van Veelen,P.A., Geurink,P.P. and Sapmaz,A.
    Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell
    J Med Chem (2024) 67, 7935-7953-7953. PubMed  Europe PubMed DOI
  17. Li,Y., Liu,X., Li,Y., Wang,J., Zhang,M., Xue,W. and Zhang,M.
    USP19 exerts a tumor-promoting role in diffuse large B cell lymphoma through stabilizing PARK7
    FEBS J (2024) 291, 4757-4774. PubMed  Europe PubMed DOI  K
  18. Shih,J.Y. and Hsu,Y.H.
    Peptide Activator Stabilizes DJ-1 Structure and Enhances Its Activity
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Sun,Y., Chen,S., Grin,I.R., Zharkov,D.O., Yu,B. and Li,H.
    The dual role of methylglyoxal in plant stress response and regulation of DJ-1 protein
    Physiol Plant (2024) 176, e14608-e14608. PubMed  Europe PubMed DOI  V
  20. Watanabe,A., Koyano,F., Imai,K., Hizukuri,Y., Ogiwara,S., Ito,T., Miyamoto,J., Shibuya,C., Kimura,M., Toriumi,K., Motono,C., Arai,M., Tanaka,K., Akiyama,Y., Yamano,K. and Matsuda,N.
    The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA
    J Biol Chem (2024) , 107476-107476. PubMed  Europe PubMed DOI
  21. Zhang,F., Wan,X., Zhan,J., Shen,M. and Li,R.
    Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis
    Front Oncol (2024) 14, 1361152-1361152. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Zielinski,K.A., Dolamore,C., Dalton,K.M., Smith,N., Termini,J., Henning,R., Srajer,V., Hekstra,D.R., Pollack,L. and Wilson,M.A.
    Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2023
  23. Andrews,T., Seravallic,J. and Powers,R.
    The reversible low-temperature instability of human DJ-1 oxidative states
    Biopolymers (2023) , e23534-e23534. PubMed  Europe PubMed DOI
  24. Chavali,L.N.M., Yddal,I., Bifulco,E., Mannsaker,S., Roise,D., Law,J.O., Froyset,A.K., Grellscheid,S.N. and Fladmark,K.E.
    Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  25. Chien,C.H., Lee,M.J. and Liou,H.C.
    Growth of B16F10 cells is enhanced in DJ-1-deficiency pancreas
    Biochem Biophys Res Commun (2023) 682, 359-364. PubMed  Europe PubMed DOI
  26. Cho,N., Joo,J., Choi,S., Kang,B.G., Lee,A.J., Youn,S.Y., Park,S.H., Kim,E.M., Masliah,E., Ko,Y., Cha,S.S., Jung,I. and Kim,K.K.
    A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction
    Heliyon (2023) 9, e14039-e14039. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Choi,J., Tak,S., Jung,H.M., Cha,S., Hwang,E., Lee,D., Lee,J.H., Ryu,K.S. and Park,C.
    Kinetic evidence in favor of glyoxalase III and against deglycase activity of DJ-1
    Protein Sci (2023) 32, e4641-e4641. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Coukos,J.S., Lee,C.W., Pillai,K.S., Shah,H. and Moellering,R.E.
    PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function
    Biochemistry (2023) 62, 3126-3133. PubMed  Europe PubMed DOI  PMC  EPMC
  29. De Lazzari,F., Agostini,F., Plotegher,N., Sandre,M., Greggio,E., Megighian,A., Bubacco,L., Sandrelli,F., Whitworth,A.J. and Bisaglia,M.
    DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis
    Neurobiol Dis (2023) 176, 105941-105941. PubMed  Europe PubMed DOI
  30. Fernandes,S.A., Dasgupta,S., Tupe,R.S. and Pathan,E.K.
    Structure-guided approach to modify the substrate specificity of the protein human deglycase-1 (hDJ-1)
    Biochem Biophys Res Commun (2023) 679, 122-128. PubMed  Europe PubMed DOI
  31. Lind-Holm Mogensen,F., Scafidi,A., Poli,A. and Michelucci,A.
    PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target
    J Neuroinflammation (2023) 20, 95-95. PubMed  Europe PubMed DOI  PMC  EPMC  V
  32. Liu,S., Xu,S., Liu,S. and Chen,H.
    Importance of DJ-1 in autophagy regulation and disease
    Arch Biochem Biophys (2023) 743, 109672-109672. PubMed  Europe PubMed DOI
  33. Niere,F., Uneri,A., McArdle,C.J., Deng,Z., Egido-Betancourt,H.X., Cacheaux,L.P., Namjoshi,S.V., Taylor,W.C., Wang,X., Barth,S.H., Reynoldson,C., Penaranda,J., Stierer,M.P., Heaney,C.F., Craft,S., Keene,C.D., Ma,T. and Raab-Graham,K.F.
    Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease
    Proc Natl Acad Sci U S A (2023) 120, e2301534120-e2301534120. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Sandrelli,F. and Bisaglia,M.
    Molecular and Physiological Determinants of Amyotrophic Lateral Sclerosis: What the DJ-1 Protein Teaches Us
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  35. Sun,M.E. and Zheng,Q.
    The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
    36. 2022
  36. Das,F., Ghosh-Choudhury,N., Maity,S., Kasinath,B.S. and Choudhury,G.G.
    Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis
    J Biol Chem (2022) 298, 102246-102246. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Galardon,E., Mathas,N., Padovani,D., Le Corre,L., Poncet,G. and Dairou,J.
    Persulfidation of DJ-1: Mechanism and Consequences
    Biomolecules (2022) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  38. Min,H.K., Kim,S.H., Lee,J.Y., Lee,S.H. and Kim,H.R.
    DJ-1 controls T cell differentiation and osteoclastogenesis in rheumatoid arthritis
    Sci Rep (2022) 12, 12767-12767. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Neves,M., Graos,M., Anjo,S.I. and Manadas,B.
    Modulation of signaling pathways by DJ-1: An updated overview
    Redox Biol (2022) 51, 102283-102283. PubMed  Europe PubMed DOI  PMC  EPMC  V
  40. Zhao,X.Y., Ren,J.M., Liu,H.R., Zhou,T.T., Wang,X.Y., Liu,S. and Chen,H.P.
    DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury
    Biochem Biophys Res Commun (2022) 637, 276-285. PubMed  Europe PubMed DOI  K
    41. 2021
  41. Atieh,T.B., Roth,J., Yang,X., Hoop,C.L. and Baum,J.
    DJ-1 Acts as a Scavenger of alpha-Synuclein Oligomers and Restores Monomeric Glycated alpha-Synuclein
    Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  42. Chen,X.B., Zhu,H.Y., Bao,K., Jiang,L., Zhu,H., Ying,M.D., He,Q.J., Yang,B., Sheng,R. and Cao,J.
    Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors
    Acta Pharmacol Sin (2021) PubMed  Europe PubMed DOI  I
  43. De Lazzari,F., Prag,H.A., Gruszczyk,A.V., Whitworth,A.J. and Bisaglia,M.
    DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury
    Redox Biol (2021) 41, 101884-101884. PubMed  Europe PubMed DOI  PMC  EPMC  V
  44. Mencke,P., Boussaad,I., Romano,C.D., Kitami,T., Linster,C.L. and Kruger,R.
    The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson's Disease
    Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  45. Sanchez-Lanzas,R. and Castano,J.G.
    Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants
    Sci Rep (2021) 11, 7320-7320. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Sircar,E., Rai,S.R., Wilson,M.A., Schlossmacher,M.G. and Sengupta,R.
    Neurodegeneration: Impact of S-nitrosylated Parkin, DJ-1 and PINK1 on the pathogenesis of Parkinson's disease
    Arch Biochem Biophys (2021) 704, 108869-108869. PubMed  Europe PubMed DOI  V
  47. Song,I.K., Kim,M.S., Ferrell,J.E., Jr., Shin,D.H. and Lee,K.J.
    Stepwise oxidations play key roles in the structural and functional regulations of DJ-1
    Biochem J (2021) 478, 3505-3525. PubMed  Europe PubMed DOI
  48. Tsoporis,J.N., Drosatos,I.A., Gupta,S., Amatullah,H., Izhar,S., Dos Santos,C.C., Salpeas,V., Rigopoulos,A.G., Toumpoulis,I.K., Triantafyllis,A.S., Sakadakis,E., Kavantzas,N., Marshall,J.C., Rizos,I.K. and Parker,T.G.
    Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology
    Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC  V
    49. 2020
  49. Almikhlafi,M.A., Stauch,K.L., Villeneuve,L.M., Purnell,P.R., Lamberty,B.G. and Fox,H.S.
    Deletion of DJ-1 in rats affects protein abundance and mitochondrial function at the synapse
    Sci Rep (2020) 10, 13719-13719. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Boussaad,I., Obermaier,C.D., Hanss,Z., Bobbili,D.R., Bolognin,S., Glaab,E., Wolynska,K., Weisschuh,N., De Conti,L., May,C., Giesert,F., Grossmann,D., Lambert,A., Kirchen,S., Biryukov,M., Burbulla,L.F., Massart,F., Bohler,J., Cruciani,G., Schmid,B., Kurz-Drexler,A., May,P., Duga,S., Klein,C., Schwamborn,J.C., Marcus,K., Woitalla,D., Vogt Weisenhorn,D.M., Wurst,W., Baralle,M., Krainc,D., Gasser,T., Wissinger,B. and Kruger,R.
    A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease
    Sci Transl Med (2020) 12 PubMed  Europe PubMed DOI
  51. Chen,S.M., Chen,T.H., Chang,H.T., Lin,T.Y., Lin,C.Y., Tsai,P.Y., Imai,K., Chen,C.M. and Lee,J.A.
    Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis
    PLoS ONE (2020) 15, e0235849-e0235849. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Daida,K., Funayama,M., Li,Y., Yoshino,H., Hayashida,A., Ikeda,A., Ogaki,K., Nishioka,K. and Hattori,N.
    Identification of Disease-Associated Variants by Targeted Gene Panel Resequencing in Parkinson's Disease
    Front Neurol (2020) 11, 576465-576465. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Ma,J., Wu,R., Zhang,Q., Wu,J.B., Lou,J., Zheng,Z., Ding,J.Q. and Yuan,Z.
    Correction: DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis
    Biochem J (2020) 477, 4813-4813. PubMed  Europe PubMed DOI
  54. Ozawa,K., Tsumoto,H., Miura,Y., Yamaguchi,J., Iguchi-Ariga,S.M.M., Sakuma,T., Yamamoto,T. and Uchiyama,Y.
    DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria
    Sci Rep (2020) 10, 4377-4377. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Sun,Y., Sun,X., Zhao,L., Zhang,Z., Wang,Y., Dai,Z., Zhao,X. and Pu,X.
    DJ-1 deficiency causes metabolic abnormality in ornidazole-induced asthenozoospermia
    Reproduction (2020) 160, 931-941. PubMed  Europe PubMed DOI
  56. Tsai,C.Y., Wu,C.J., Wu,J.C.C., Fang,C., Huang,Y.H. and Dai,K.Y.
    Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication
    Neurochem Int (2020) , 104791-104791. PubMed  Europe PubMed DOI
  57. Upadhyay,M., Milliner,C., Bell,B.A. and Bonilha,V.L.
    Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1
    Redox Biol (2020) , 101623-101623. PubMed  Europe PubMed DOI
  58. Zhang,L., Wang,J., Wang,J., Yang,B., He,Q. and Weng,Q.
    Role of DJ-1 in Immune and Inflammatory Diseases
    Front Immunol (2020) 11, 994-994. PubMed  Europe PubMed DOI  PMC  EPMC  V
    59. 2019
  59. Andreeva,A., Bekkhozhin,Z., Omertassova,N., Baizhumanov,T., Yeltay,G., Akhmetali,M., Toibazar,D. and Utepbergenov,D.
    The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals
    J Biol Chem (2019) 294, 18863-18872. PubMed  Europe PubMed DOI  M
  60. Barbieri,L. and Luchinat,E.
    Backbone resonance assignment of human DJ-1 in the reduced state and in the cysteine sulfinic acid state
    Biomol NMR Assign (2019) 13, 371-376. PubMed  Europe PubMed DOI  S
  61. Kumar,A., Mukherjee,D. and Satpati,P.
    Mutations in Parkinson's disease associated protein DJ-1 alter the energetics of DJ-1 dimerization
    J Chem Inf Model (2019) 59, 1497-1507. PubMed  Europe PubMed DOI  M
  62. Kumar,R., Kumar,S., Hanpude,P., Singh,A.K., Johari,T., Majumder,S. and Maiti,T.K.
    Partially oxidized DJ-1 inhibits alpha-synuclein nucleation and remodels mature alpha-synuclein fibrils in vitro
    Commun Biol (2019) 2, 395-395. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Lewandowska,A., Vo,T.N., Nguyen,T.H., Wahni,K., Vertommen,D., Van Breusegem,F., Young,D. and Messens,J.
    Bifunctional chloroplastic DJ-1B from Arabidopsis thaliana is an oxidation-robust holdase and a glyoxalase sensitive to H(2)O(2)
    Antioxidants (Basel) (2019) 8 PubMed  Europe PubMed DOI
  64. Pandey,S., Dhusia,K., Katara,P., Singh,S. and Gautam,B.
    An in silico analysis of deleterious single nucleotide polymorphisms and molecular dynamics simulation of disease linked mutations in genes responsible for neurodegenerative disorder
    J Biomol Struct Dyn (2019) , 1-14. PubMed  Europe PubMed DOI  M
    65. 2018
  65. Drechsel,J., Mandl,F.A. and Sieber,S.A.
    Chemical probe to monitor the parkinsonism-associated protein DJ-1 in live cells
    ACS Chem Biol (2018) 13, 2016-2019. PubMed  Europe PubMed DOI
  66. Mussakhmetov,A., Shumilin,I.A., Nugmanova,R., Shabalin,I.G., Baizhumanov,T., Toibazar,D., Khassenov,B., Minor,W. and Utepbergenov,D.
    A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1
    Biochem Biophys Res Commun (2018) 504, 328-333. PubMed  Europe PubMed DOI
  67. Nair,D.N., Prasad,R., Singhal,N., Bhattacharjee,M., Sudhakar,R., Singh,P., Thanumalayan,S., Kiran,U., Sharma,Y. and Sijwali,P.S.
    A conserved human DJ1-subfamily motif (DJSM) is critical for anti-oxidative and deglycase activities of Plasmodium falciparum DJ1
    Mol Biochem Parasitol (2018) 222, 70-80. PubMed  Europe PubMed DOI
  68. Strobbe,D., Robinson,A.A., Harvey,K., Rossi,L., Ferraina,C., de Biase,V., Rodolfo,C., Harvey,R.J. and Campanella,M.
    Distinct mechanisms of pathogenic DJ-1 mutations in mitochondrial quality control
    Front Mol Neurosci (2018) 11, 68-68. PubMed  Europe PubMed DOI  PMC  EPMC  M
  69. Tashiro,S., Caaveiro,J.M.M., Nakakido,M., Tanabe,A., Nagatoishi,S., Tamura,Y., Matsuda,N., Liu,D., Hoang,Q.Q. and Tsumoto,K.
    Discovery and optimization of inhibitors of the Parkinson's disease associated protein DJ-1
    ACS Chem Biol (2018) 13, 2783-2793. PubMed  Europe PubMed DOI  I
    70. 2017
  70. Biosa,A., Sandrelli,F., Beltramini,M., Greggio,E., Bubacco,L. and Bisaglia,M.
    Recent findings on the physiological function of DJ-1: beyond Parkinson's disease
    Neurobiol Dis (2017) 108, 65-72. PubMed  Europe PubMed DOI
  71. De Lazzari,F. and Bisaglia,M.
    DJ-1 as a deglycating enzyme: a unique function to explain a multifaceted protein?
    Neural Regen Res (2017) 12, 1797-1798. PubMed  Europe PubMed DOI
  72. Fu,K., Wang,Y., Guo,D., Wang,G. and Ren,H.
    Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2
    Neurosci Bull (2017) 33, 685-694. PubMed  Europe PubMed DOI  M
  73. Hijioka,M., Inden,M., Yanagisawa,D. and Kitamura,Y.
    DJ-1/PARK7: a new therapeutic target for neurodegenerative disorders
    Biol Pharm Bull (2017) 40, 548-552. PubMed  Europe PubMed DOI  M
  74. Kiss,R., Zhu,M., Jojart,B., Czajlik,A., Solti,K., Forizs,B., Nagy,E., Zsila,F., Beke-Somfai,T. and Toth,G.
    Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease
    Biochim Biophys Acta (2017) 1861, 2619-2629. PubMed  Europe PubMed DOI
  75. Matsuda,N., Kimura,M., Queliconi,B.B., Kojima,W., Mishima,M., Takagi,K., Koyano,F., Yamano,K., Mizushima,T., Ito,Y. and Tanaka,K.
    Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro
    Sci Rep (2017) 7, 12816-12816. PubMed  Europe PubMed DOI  PMC  EPMC
  76. Pfaff,D.H., Fleming,T., Nawroth,P. and Teleman,A.A.
    Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification
    J Biol Chem (2017) 292, 685-690. PubMed  Europe PubMed DOI
  77. Richarme,G. and Dairou,J.
    Parkinsonism-associated protein DJ-1 is a bona fide deglycase
    Biochem Biophys Res Commun (2017) 483, 387-391. PubMed  Europe PubMed DOI
    78. 2016
  78. Fernandez-Caggiano,M., Schroder,E., Cho,H.J., Burgoyne,J., Barallobre-Barreiro,J., Mayr,M. and Eaton,P.
    Oxidant-induced Interprotein disulfide formation in cardiac protein DJ-1 occurs via an interaction with peroxiredoxin 2
    J Biol Chem (2016) 291, 10399-10410. PubMed  Europe PubMed DOI
  79. Richarme,G., Marguet,E., Forterre,P., Ishino,S. and Ishino,Y.
    DJ-1 family Maillard deglycases prevent acrylamide formation
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