Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C56.002: DJ-1 putative peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Alipour,M., Hajipour-Verdom,B., Zali,A., Ashrafi,F., Abdolmaleki,P., Oraee-Yazdani,S., Akhlaghdoust,M. and Karimi,N.
    Interaction of alpha-synuclein with DJ-1 in homodimer and L166P mutant monomer forms in Parkinson's disease: a molecular dynamics study
    J Biomol Struct Dyn1-8. PubMed  Europe PubMed DOI
  2. Alshammari,Q.A.
    Redox modulatory role of DJ-1 in Parkinson's disease
    Biogerontology26, 81-81. PubMed  Europe PubMed DOI  V
  3. Zhao,A., Ding,Y., Zhong,M., Niu,M., Wang,L., Jiao,Y., Liu,J. and Li,Y.
    Neuronal DJ-1 regulates microglial activation in Parkinson's disease
    Neural Regen Res PubMed  Europe PubMed DOI  K
    4. 2024
  4. Akhmadi,A., Yeskendir,A., Dey,N., Mussakhmetov,A., Shatkenova,Z., Kulyyassov,A., Andreeva,A. and Utepbergenov,D.
    DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
    Nat Commun15, 2004-2004. PubMed  Europe PubMed DOI
  5. Bekmagambetov,A., Shkraba,E., Yeskendir,A., Akhmadi,A. and Utepbergenov,D.
    cPGA hydrolase assay of DJ-1 in crude cell lysates: Implications for sensing of oxidative stress
    Anal Biochem694, 115631-115631. PubMed  Europe PubMed DOI
  6. Dhinesh Kumar,M., Karthikeyan,M., Kaniraja,G., Muthukumar,K., Muneeswaran,G. and Karunakaran,C.
    Computational modelling and optimization studies of electropentamer for molecular imprinting of DJ-1
    J Mol Graph Model128, 108715-108715. PubMed  Europe PubMed DOI
  7. Ji,Y.W., Wen,X.Y., Tang,H.P., Jin,Z.S., Su,W.T., Zhou,L., Xia,Z.Y., Xia,Z.Y. and Lei,S.Q.
    DJ-1: Potential target for treatment of myocardial ischemia-reperfusion injury
    Biomed Pharmacother179, 117383-117383. PubMed  Europe PubMed DOI  V
  8. Jia,Y., Oyken,M., Kim,R.Q., Tjokrodirijo,R.T.N., de Ru,A.H., Janssen,A.P.A., Hacker,S.M., van Veelen,P.A., Geurink,P.P. and Sapmaz,A.
    Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell
    J Med Chem67, 7935-7953-7953. PubMed  Europe PubMed DOI
  9. Li,Y., Liu,X., Li,Y., Wang,J., Zhang,M., Xue,W. and Zhang,M.
    USP19 exerts a tumor-promoting role in diffuse large B cell lymphoma through stabilizing PARK7
    FEBS J291, 4757-4774. PubMed  Europe PubMed DOI  K
  10. Shih,J.Y. and Hsu,Y.H.
    Peptide Activator Stabilizes DJ-1 Structure and Enhances Its Activity
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  11. Sun,Y., Chen,S., Grin,I.R., Zharkov,D.O., Yu,B. and Li,H.
    The dual role of methylglyoxal in plant stress response and regulation of DJ-1 protein
    Physiol Plant176, e14608-e14608. PubMed  Europe PubMed DOI  V
  12. Watanabe,A., Koyano,F., Imai,K., Hizukuri,Y., Ogiwara,S., Ito,T., Miyamoto,J., Shibuya,C., Kimura,M., Toriumi,K., Motono,C., Arai,M., Tanaka,K., Akiyama,Y., Yamano,K. and Matsuda,N.
    The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA
    J Biol Chem107476-107476. PubMed  Europe PubMed DOI
  13. Zhang,F., Wan,X., Zhan,J., Shen,M. and Li,R.
    Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis
    Front Oncol14, 1361152-1361152. PubMed  Europe PubMed DOI
  14. Zielinski,K.A., Dolamore,C., Dalton,K.M., Smith,N., Termini,J., Henning,R., Srajer,V., Hekstra,D.R., Pollack,L. and Wilson,M.A.
    Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron
    bioRxiv PubMed  Europe PubMed DOI
    15. 2023
  15. Andrews,T., Seravallic,J. and Powers,R.
    The reversible low-temperature instability of human DJ-1 oxidative states
    Biopolymerse23534-e23534. PubMed  Europe PubMed DOI
  16. Chavali,L.N.M., Yddal,I., Bifulco,E., Mannsaker,S., Roise,D., Law,J.O., Froyset,A.K., Grellscheid,S.N. and Fladmark,K.E.
    Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  17. Chien,C.H., Lee,M.J. and Liou,H.C.
    Growth of B16F10 cells is enhanced in DJ-1-deficiency pancreas
    Biochem Biophys Res Commun682, 359-364. PubMed  Europe PubMed DOI
  18. Cho,N., Joo,J., Choi,S., Kang,B.G., Lee,A.J., Youn,S.Y., Park,S.H., Kim,E.M., Masliah,E., Ko,Y., Cha,S.S., Jung,I. and Kim,K.K.
    A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction
    Heliyon9, e14039-e14039. PubMed  Europe PubMed DOI
  19. Choi,J., Tak,S., Jung,H.M., Cha,S., Hwang,E., Lee,D., Lee,J.H., Ryu,K.S. and Park,C.
    Kinetic evidence in favor of glyoxalase III and against deglycase activity of DJ-1
    Protein Sci32, e4641-e4641. PubMed  Europe PubMed DOI
  20. Coukos,J.S., Lee,C.W., Pillai,K.S., Shah,H. and Moellering,R.E.
    PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function
    Biochemistry62, 3126-3133. PubMed  Europe PubMed DOI
  21. De Lazzari,F., Agostini,F., Plotegher,N., Sandre,M., Greggio,E., Megighian,A., Bubacco,L., Sandrelli,F., Whitworth,A.J. and Bisaglia,M.
    DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis
    Neurobiol Dis176, 105941-105941. PubMed  Europe PubMed DOI
  22. Fernandes,S.A., Dasgupta,S., Tupe,R.S. and Pathan,E.K.
    Structure-guided approach to modify the substrate specificity of the protein human deglycase-1 (hDJ-1)
    Biochem Biophys Res Commun679, 122-128. PubMed  Europe PubMed DOI
  23. Lind-Holm Mogensen,F., Scafidi,A., Poli,A. and Michelucci,A.
    PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target
    J Neuroinflammation20, 95-95. PubMed  Europe PubMed DOI  V
  24. Liu,S., Xu,S., Liu,S. and Chen,H.
    Importance of DJ-1 in autophagy regulation and disease
    Arch Biochem Biophys743, 109672-109672. PubMed  Europe PubMed DOI
  25. Niere,F., Uneri,A., McArdle,C.J., Deng,Z., Egido-Betancourt,H.X., Cacheaux,L.P., Namjoshi,S.V., Taylor,W.C., Wang,X., Barth,S.H., Reynoldson,C., Penaranda,J., Stierer,M.P., Heaney,C.F., Craft,S., Keene,C.D., Ma,T. and Raab-Graham,K.F.
    Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease
    Proc Natl Acad Sci U S A120, e2301534120-e2301534120. PubMed  Europe PubMed DOI
  26. Sandrelli,F. and Bisaglia,M.
    Molecular and Physiological Determinants of Amyotrophic Lateral Sclerosis: What the DJ-1 Protein Teaches Us
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  27. Sun,M.E. and Zheng,Q.
    The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
    28. 2022
  28. Das,F., Ghosh-Choudhury,N., Maity,S., Kasinath,B.S. and Choudhury,G.G.
    Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis
    J Biol Chem298, 102246-102246. PubMed  Europe PubMed DOI
  29. Galardon,E., Mathas,N., Padovani,D., Le Corre,L., Poncet,G. and Dairou,J.
    Persulfidation of DJ-1: Mechanism and Consequences
    Biomolecules13, PubMed  Europe PubMed DOI
  30. Neves,M., Graos,M., Anjo,S.I. and Manadas,B.
    Modulation of signaling pathways by DJ-1: An updated overview
    Redox Biol51, 102283-102283. PubMed  Europe PubMed DOI  V
  31. Zhao,X.Y., Ren,J.M., Liu,H.R., Zhou,T.T., Wang,X.Y., Liu,S. and Chen,H.P.
    DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury
    Biochem Biophys Res Commun637, 276-285. PubMed  Europe PubMed DOI  K
    32. 2021
  32. Atieh,T.B., Roth,J., Yang,X., Hoop,C.L. and Baum,J.
    DJ-1 Acts as a Scavenger of alpha-Synuclein Oligomers and Restores Monomeric Glycated alpha-Synuclein
    Biomolecules11, PubMed  Europe PubMed DOI
  33. Chen,X.B., Zhu,H.Y., Bao,K., Jiang,L., Zhu,H., Ying,M.D., He,Q.J., Yang,B., Sheng,R. and Cao,J.
    Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors
    Acta Pharmacol Sin PubMed  Europe PubMed DOI  I
  34. De Lazzari,F., Prag,H.A., Gruszczyk,A.V., Whitworth,A.J. and Bisaglia,M.
    DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury
    Redox Biol41, 101884-101884. PubMed  Europe PubMed DOI  V
  35. Mencke,P., Boussaad,I., Romano,C.D., Kitami,T., Linster,C.L. and Kruger,R.
    The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson's Disease
    Cells10, PubMed  Europe PubMed DOI
  36. Sanchez-Lanzas,R. and Castano,J.G.
    Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants
    Sci Rep11, 7320-7320. PubMed  Europe PubMed DOI
  37. Sircar,E., Rai,S.R., Wilson,M.A., Schlossmacher,M.G. and Sengupta,R.
    Neurodegeneration: Impact of S-nitrosylated Parkin, DJ-1 and PINK1 on the pathogenesis of Parkinson's disease
    Arch Biochem Biophys704, 108869-108869. PubMed  Europe PubMed DOI  V
  38. Song,I.K., Kim,M.S., Ferrell,J.E., Jr., Shin,D.H. and Lee,K.J.
    Stepwise oxidations play key roles in the structural and functional regulations of DJ-1
    Biochem J478, 3505-3525. PubMed  Europe PubMed DOI
  39. Tsoporis,J.N., Drosatos,I.A., Gupta,S., Amatullah,H., Izhar,S., Dos Santos,C.C., Salpeas,V., Rigopoulos,A.G., Toumpoulis,I.K., Triantafyllis,A.S., Sakadakis,E., Kavantzas,N., Marshall,J.C., Rizos,I.K. and Parker,T.G.
    Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology
    Molecules26, PubMed  Europe PubMed DOI  V
    40. 2020
  40. Almikhlafi,M.A., Stauch,K.L., Villeneuve,L.M., Purnell,P.R., Lamberty,B.G. and Fox,H.S.
    Deletion of DJ-1 in rats affects protein abundance and mitochondrial function at the synapse
    Sci Rep10, 13719-13719. PubMed  Europe PubMed DOI
  41. Boussaad,I., Obermaier,C.D., Hanss,Z., Bobbili,D.R., Bolognin,S., Glaab,E., Wolynska,K., Weisschuh,N., De Conti,L., May,C., Giesert,F., Grossmann,D., Lambert,A., Kirchen,S., Biryukov,M., Burbulla,L.F., Massart,F., Bohler,J., Cruciani,G., Schmid,B., Kurz-Drexler,A., May,P., Duga,S., Klein,C., Schwamborn,J.C., Marcus,K., Woitalla,D., Vogt Weisenhorn,D.M., Wurst,W., Baralle,M., Krainc,D., Gasser,T., Wissinger,B. and Kruger,R.
    A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease
    Sci Transl Med12, PubMed  Europe PubMed DOI
  42. Chen,S.M., Chen,T.H., Chang,H.T., Lin,T.Y., Lin,C.Y., Tsai,P.Y., Imai,K., Chen,C.M. and Lee,J.A.
    Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis
    PLoS ONE15, e0235849-e0235849. PubMed  Europe PubMed DOI
  43. Daida,K., Funayama,M., Li,Y., Yoshino,H., Hayashida,A., Ikeda,A., Ogaki,K., Nishioka,K. and Hattori,N.
    Identification of Disease-Associated Variants by Targeted Gene Panel Resequencing in Parkinson's Disease
    Front Neurol11, 576465-576465. PubMed  Europe PubMed DOI
  44. Ma,J., Wu,R., Zhang,Q., Wu,J.B., Lou,J., Zheng,Z., Ding,J.Q. and Yuan,Z.
    Correction: DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis
    Biochem J477, 4813-4813. PubMed  Europe PubMed DOI
  45. Ozawa,K., Tsumoto,H., Miura,Y., Yamaguchi,J., Iguchi-Ariga,S.M.M., Sakuma,T., Yamamoto,T. and Uchiyama,Y.
    DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria
    Sci Rep10, 4377-4377. PubMed  Europe PubMed DOI
  46. Sun,Y., Sun,X., Zhao,L., Zhang,Z., Wang,Y., Dai,Z., Zhao,X. and Pu,X.
    DJ-1 deficiency causes metabolic abnormality in ornidazole-induced asthenozoospermia
    Reproduction160, 931-941. PubMed  Europe PubMed DOI
  47. Tsai,C.Y., Wu,C.J., Wu,J.C.C., Fang,C., Huang,Y.H. and Dai,K.Y.
    Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication
    Neurochem Int104791-104791. PubMed  Europe PubMed DOI
  48. Upadhyay,M., Milliner,C., Bell,B.A. and Bonilha,V.L.
    Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1
    Redox Biol101623-101623. PubMed  Europe PubMed DOI
  49. Zhang,L., Wang,J., Wang,J., Yang,B., He,Q. and Weng,Q.
    Role of DJ-1 in Immune and Inflammatory Diseases
    Front Immunol11, 994-994. PubMed  Europe PubMed DOI  V
    50. 2019
  50. Andreeva,A., Bekkhozhin,Z., Omertassova,N., Baizhumanov,T., Yeltay,G., Akhmetali,M., Toibazar,D. and Utepbergenov,D.
    The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals
    J Biol Chem294, 18863-18872. PubMed  Europe PubMed DOI  M
  51. Barbieri,L. and Luchinat,E.
    Backbone resonance assignment of human DJ-1 in the reduced state and in the cysteine sulfinic acid state
    Biomol NMR Assign13, 371-376. PubMed  Europe PubMed DOI  S
  52. Kumar,A., Mukherjee,D. and Satpati,P.
    Mutations in Parkinson's disease associated protein DJ-1 alter the energetics of DJ-1 dimerization
    J Chem Inf Model59, 1497-1507. PubMed  Europe PubMed DOI  M
  53. Kumar,R., Kumar,S., Hanpude,P., Singh,A.K., Johari,T., Majumder,S. and Maiti,T.K.
    Partially oxidized DJ-1 inhibits alpha-synuclein nucleation and remodels mature alpha-synuclein fibrils in vitro
    Commun Biol2, 395-395. PubMed  Europe PubMed DOI
  54. Lewandowska,A., Vo,T.N., Nguyen,T.H., Wahni,K., Vertommen,D., Van Breusegem,F., Young,D. and Messens,J.
    Bifunctional chloroplastic DJ-1B from Arabidopsis thaliana is an oxidation-robust holdase and a glyoxalase sensitive to H(2)O(2)
    Antioxidants (Basel)8, PubMed  Europe PubMed DOI
  55. Pandey,S., Dhusia,K., Katara,P., Singh,S. and Gautam,B.
    An in silico analysis of deleterious single nucleotide polymorphisms and molecular dynamics simulation of disease linked mutations in genes responsible for neurodegenerative disorder
    J Biomol Struct Dyn1-14. PubMed  Europe PubMed DOI  M
    56. 2018
  56. Drechsel,J., Mandl,F.A. and Sieber,S.A.
    Chemical probe to monitor the parkinsonism-associated protein DJ-1 in live cells
    ACS Chem Biol13, 2016-2019. PubMed  Europe PubMed DOI
  57. Mussakhmetov,A., Shumilin,I.A., Nugmanova,R., Shabalin,I.G., Baizhumanov,T., Toibazar,D., Khassenov,B., Minor,W. and Utepbergenov,D.
    A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1
    Biochem Biophys Res Commun504, 328-333. PubMed  Europe PubMed DOI
  58. Nair,D.N., Prasad,R., Singhal,N., Bhattacharjee,M., Sudhakar,R., Singh,P., Thanumalayan,S., Kiran,U., Sharma,Y. and Sijwali,P.S.
    A conserved human DJ1-subfamily motif (DJSM) is critical for anti-oxidative and deglycase activities of Plasmodium falciparum DJ1
    Mol Biochem Parasitol222, 70-80. PubMed  Europe PubMed DOI
  59. Strobbe,D., Robinson,A.A., Harvey,K., Rossi,L., Ferraina,C., de Biase,V., Rodolfo,C., Harvey,R.J. and Campanella,M.
    Distinct mechanisms of pathogenic DJ-1 mutations in mitochondrial quality control
    Front Mol Neurosci11, 68-68. PubMed  Europe PubMed DOI  M
  60. Tashiro,S., Caaveiro,J.M.M., Nakakido,M., Tanabe,A., Nagatoishi,S., Tamura,Y., Matsuda,N., Liu,D., Hoang,Q.Q. and Tsumoto,K.
    Discovery and optimization of inhibitors of the Parkinson's disease associated protein DJ-1
    ACS Chem Biol13, 2783-2793. PubMed  Europe PubMed DOI  I
    61. 2017
  61. Biosa,A., Sandrelli,F., Beltramini,M., Greggio,E., Bubacco,L. and Bisaglia,M.
    Recent findings on the physiological function of DJ-1: beyond Parkinson's disease
    Neurobiol Dis108, 65-72. PubMed  Europe PubMed DOI
  62. De Lazzari,F. and Bisaglia,M.
    DJ-1 as a deglycating enzyme: a unique function to explain a multifaceted protein?
    Neural Regen Res12, 1797-1798. PubMed  Europe PubMed DOI
  63. Fu,K., Wang,Y., Guo,D., Wang,G. and Ren,H.
    Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2
    Neurosci Bull33, 685-694. PubMed  Europe PubMed DOI  M
  64. Hijioka,M., Inden,M., Yanagisawa,D. and Kitamura,Y.
    DJ-1/PARK7: a new therapeutic target for neurodegenerative disorders
    Biol Pharm Bull40, 548-552. PubMed  Europe PubMed DOI  M
  65. Kiss,R., Zhu,M., Jojart,B., Czajlik,A., Solti,K., Forizs,B., Nagy,E., Zsila,F., Beke-Somfai,T. and Toth,G.
    Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease
    Biochim Biophys Acta1861, 2619-2629. PubMed  Europe PubMed DOI
  66. Matsuda,N., Kimura,M., Queliconi,B.B., Kojima,W., Mishima,M., Takagi,K., Koyano,F., Yamano,K., Mizushima,T., Ito,Y. and Tanaka,K.
    Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro
    Sci Rep7, 12816-12816. PubMed  Europe PubMed DOI
  67. Pfaff,D.H., Fleming,T., Nawroth,P. and Teleman,A.A.
    Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification
    J Biol Chem292, 685-690. PubMed  Europe PubMed DOI
  68. Richarme,G. and Dairou,J.
    Parkinsonism-associated protein DJ-1 is a bona fide deglycase
    Biochem Biophys Res Commun483, 387-391. PubMed  Europe PubMed DOI
    69. 2016
  69. Fernandez-Caggiano,M., Schroder,E., Cho,H.J., Burgoyne,J., Barallobre-Barreiro,J., Mayr,M. and Eaton,P.
    Oxidant-induced Interprotein disulfide formation in cardiac protein DJ-1 occurs via an interaction with peroxiredoxin 2
    J Biol Chem291, 10399-10410. PubMed  Europe PubMed DOI
  70. Richarme,G., Marguet,E., Forterre,P., Ishino,S. and Ishino,Y.
    DJ-1 family Maillard deglycases prevent acrylamide formation
    Biochem Biophys Res Commun478, 1111-1116. PubMed  Europe PubMed DOI
  71. Vazquez-Mayorga,E., Diaz-Sanchez,A.G., Dagda,R.K., Dominguez-Solis,C.A., Dagda,R.Y., Coronado-Ramirez,C.K. and Martinez-Martinez,A.
    Novel redox-dependent esterase activity (EC 3.1.1.2) for DJ-1: implications for Parkinson's disease
    Int J Mol Sci17, PubMed  Europe PubMed DOI
    72. 2015
  72. Milkovic,N.M., Catazaro,J., Lin,J., Halouska,S., Kizziah,J.L., Basiaga,S., Cerny,R.L., Powers,R. and Wilson,M.A.
    Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature
    Protein Sci24, 1671-1685. PubMed  Europe PubMed DOI  S
  73. Moscovitz,O., Ben-Nissan,G., Fainer,I., Pollack,D., Mizrachi,L. and Sharon,M.
    The Parkinson's-associated protein DJ-1 regulates the 20S proteasome
    Nat Commun6, 6609-6609. PubMed  Europe PubMed DOI
  74. Richarme,G., Mihoub,M., Dairou,J., Bui,L.C., Leger,T. and Lamouri,A.
    Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues
    J Biol Chem290, 1885-1897. PubMed  Europe PubMed DOI
    75. 2014
  75. Prahlad,J., Hauser,D.N., Milkovic,N.M., Cookson,M.R. and Wilson,M.A.
    Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers
    J Neurochem130, 839-853. PubMed  Europe PubMed DOI
  76. Tashiro,S., Caaveiro,J.M., Wu,C.X., Hoang,Q.Q. and Tsumoto,K.
    Thermodynamic and structural characterization of the specific binding of Zn(II) to human protein DJ-1
    Biochemistry53, 2218-2220. PubMed  Europe PubMed DOI
    77. 2013
  77. Hwang,S., Song,S., Hong,Y.K., Choi,G., Suh,Y.S., Han,S.Y., Lee,M., Park,S.H., Lee,J.H., Lee,S., Bang,S.M., Jeong,Y., Chung,W.J., Lee,I.S., Jeong,G., Chung,J. and Cho,K.S.
    Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO
    PLoS Genet9, e1003412-e1003412. PubMed  Europe PubMed DOI
  78. Li,B., Yu,D. and Xu,Z.
    Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease
    J Mol Neurosci51, 539-549. PubMed  Europe PubMed DOI  M
  79. Maita,C., Maita,H., Iguchi-Ariga,S.M. and Ariga,H.
    Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants
    PLoS ONE8, e54087-e54087. PubMed  Europe PubMed DOI
  80. Mitsugi,H., Niki,T., Takahashi-Niki,K., Tanimura,K., Yoshizawa-Kumagaye,K., Tsunemi,M., Iguchi-Ariga,S.M. and Ariga,H.
    Identification of the recognition sequence and target proteins for DJ-1 protease
    FEBS Lett587, 2493-2499. PubMed  Europe PubMed DOI  P
    81. 2012
  81. Girotto,S., Sturlese,M., Bellanda,M., Tessari,I., Cappellini,R., Bisaglia,M., Bubacco,L. and Mammi,S.
    Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53
    J Biol Chem287, 18738-18749. PubMed  Europe PubMed DOI
  82. Jung,H.J., Kim,S., Kim,Y.J., Kim,M.K., Kang,S.G., Lee,J.H., Kim,W. and Cha,S.S.
    Dissection of the dimerization modes in the DJ-1 superfamily
    Mol Cells33, 163-171. PubMed  Europe PubMed DOI
  83. Lee,J.Y., Song,J., Kwon,K., Jang,S., Kim,C., Baek,K., Kim,J. and Park,C.
    Human DJ-1 and its homologs are novel glyoxalases
    Hum Mol Genet21, 3215-3225. PubMed  Europe PubMed DOI
  84. Lin,J., Prahlad,J. and Wilson,M.A.
    Conservation of oxidative protein stabilization in an insect homologue of Parkinsonism-associated protein DJ-1
    Biochemistry51, 3799-3807. PubMed  Europe PubMed DOI
  85. Madzelan,P., Labunska,T. and Wilson,M.A.
    Influence of peptide dipoles and hydrogen bonds on reactive cysteine pKa values in fission yeast DJ-1
    FEBS J279, 4111-4120. PubMed  Europe PubMed DOI
  86. Stefanatos,R., Sriram,A., Kiviranta,E., Mohan,A., Ayala,V., Jacobs,H.T., Pamplona,R. and Sanz,A.
    dj-1beta regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster
    Cell Cycle11, 3876-3886. PubMed  Europe PubMed DOI
    87. 2011
  87. Lin,J., Nazarenus,T.J., Frey,J.L., Liang,X., Wilson,M.A. and Stone,J.M.
    A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development
    PLoS ONE6, e23731-e23731. PubMed  Europe PubMed DOI
  88. Wilson,M.A.
    The role of cysteine oxidation in DJ-1 function and dysfunction
    Antioxid Redox Signal15, 111-122. PubMed  Europe PubMed DOI
    89. 2010
  89. Chen,J., Li,L. and Chin,L.S.
    Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage
    Hum Mol Genet19, 2395-2408. PubMed  Europe PubMed DOI
  90. Giaime,E., Sunyach,C., Druon,C., Scarzello,S., Robert,G., Grosso,S., Auberger,P., Goldberg,M.S., Shen,J., Heutink,P., Pouyssegur,J., Pages,G., Checler,F. and Alves da Costa,C.
    Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6
    Cell Death Differ17, 158-169. PubMed  Europe PubMed DOI
  91. Ramsey,C.P. and Giasson,B.I.
    L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments
    J Neurosci Res88, 3111-3124. PubMed  Europe PubMed DOI
    92. 2008
  92. Lakshminarasimhan,M., Maldonado,M.T., Zhou,W., Fink,A.L. and Wilson,M.A.
    Structural impact of three Parkinsonism-associated missense mutations on human DJ-1
    Biochemistry47, 1381-1392. PubMed  Europe PubMed DOI  M  S
    93. 2007
  93. Koide-Yoshida,S., Niki,T., Ueda,M., Himeno,S., Taira,T., Iguchi-Ariga,S.M., Ando,Y. and Ariga,H.
    DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy
    Int J Mol Med19, 885-893. PubMed  Europe PubMed
  94. Zhang,D., Lim,S.G. and Koay,E.S.
    Proteomic identification of down-regulation of oncoprotein DJ-1 and proteasome activator subunit 1 in hepatitis B virus-infected well-differentiated hepatocellular carcinoma
    Int J Oncol31, 577-584. PubMed  Europe PubMed
    95. 2006
  95. Gosal,D., Ross,O.A. and Toft,M.
    Parkinson's disease: the genetics of a heterogeneous disorder
    Eur J Neurol13, 616-627. PubMed  Europe PubMed DOI
  96. Sekito,A., Koide-Yoshida,S., Niki,T., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
    DJ-1 interacts with HIPK1 and affects H2O2-induced cell death
    Free Radic Res40, 155-165. PubMed  Europe PubMed DOI
    97. 2004
  97. [YEAR:19-2-2004]Bandyopadhyay,S. and Cookson,M.R.
    Evolutionary and functional relationships within the DJ1 superfamily
    BMC Evol Biol4, 6-6. PubMed  Europe PubMed DOI
  98. [YEAR:8-1-2004]Bonifati,V., Oostra,B.A. and Heutink,P.
    Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease
    J Mol Med82, 163-174. PubMed  Europe PubMed DOI
  99. Hicks,P.M., Chang,L.S. and Kelly,R.M.
    Pyrococcus furiosus protease I
    [ISSN:0-12-079610-4]2, 1393-1395.  V
  100. [YEAR:9-12-2004]Olzmann,J.A., Brown,K., Wilkinson,K.D., Rees,H.D., Huai,Q., Ke,H., Levey,A.I., Li,L. and Chin,L.S.
    Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
    J Biol Chem279, 8506-8515. PubMed  Europe PubMed DOI
  101. Rizzu,P., Hinkle,D.A., Zhukareva,V., Bonifati,V., Severijnen,L.A., Martinez,D., Ravid,R., Kamphorst,W., Eberwine,J.H., Lee,V.M., Trojanowski,J.Q. and Heutink,P.
    DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia
    Ann Neurol55, 113-118. PubMed  Europe PubMed DOI
  102. [YEAR:23-7-2004]Takahashi-Niki,K., Niki,T., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
    Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients
    Biochem Biophys Res Commun320, 389-397. PubMed  Europe PubMed DOI
    103. 2003
  103. Hague,S., Rogaeva,E., Hernandez,D., Gulick,C., Singleton,A., Hanson,M., Johnson,J., Weiser,R., Gallardo,M., Ravina,B., Gwinn-Hardy,K., Crawley,A., St George-Hyslop,P.H., Lang,A.E., Heutink,P., Bonifati,V., Hardy,J. and Singleton,A.
    Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation
    Ann Neurol54, 271-274. PubMed  Europe PubMed DOI
  104. [YEAR:7-11-2003]Lee,S.J., Kim,S.J., Kim,I.K., Ko,J., Jeong,C.S., Kim,G.H., Park,C., Kang,S.O., Suh,P.G., Lee,H.S. and Cha,S.S.
    Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain
    J Biol Chem278, 44552-44559. PubMed  Europe PubMed DOI  S
    105. 2001
  105. [YEAR:24-1-2001]Taira,T., Takahashi,K., Kitagawa,R., Iguchi-Ariga,S.M. and Ariga,H.
    Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter
    Gene263, 285-292. PubMed  Europe PubMed DOI
  106. [YEAR:5-10-2001]Takahashi,K., Taira,T., Niki,T., Seino,C., Iguchi-Ariga,S.M. and Ariga,H.
    DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
    J Biol Chem276, 37556-37563. PubMed  Europe PubMed DOI
    107. 2000
  107. Wagenfeld,A., Yeung,C.H., Shivaji,S., Sundareswaran,V.R., Ariga,H. and Cooper,T.G.
    Expression and cellular localization of contraception-associated protein
    J Androl21, 954-963. PubMed  Europe PubMed
    108. 1999
  108. [YEAR:1-3-1999]Hod,Y., Pentyala,S.N., Whyard,T.C. and El-Maghrabi,M.R.
    Identification and characterization of a novel protein that regulates RNA-protein interaction
    J Cell Biochem72, 435-444. PubMed  Europe PubMed DOI
    109. 1998
  109. [YEAR:20-10-1998]Wagenfeld,A., Gromoll,J. and Cooper,T.G.
    Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization
    Biochem Biophys Res Commun251, 545-549. PubMed  Europe PubMed DOI
    110. 1997
  110. [YEAR:13-2-1997]Nagakubo,D., Taira,T., Kitaura,H., Ikeda,M., Tamai,K., Iguchi-Ariga,S.M. and Ariga,H.
    DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras
    Biochem Biophys Res Commun231, 509-513. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use