Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C56.002: DJ-1 putative peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Alipour,M., Hajipour-Verdom,B., Zali,A., Ashrafi,F., Abdolmaleki,P., Oraee-Yazdani,S., Akhlaghdoust,M. and Karimi,N.<br>Interaction of alpha-synuclein with DJ-1 in homodimer and L166P mutant monomer forms in Parkinson's disease: a molecular dynamics study<br>J Biomol Struct Dyn (2025) , 1-8. PubMed  Europe PubMed DOI
  2. Alshammari,Q.A.<br>Redox modulatory role of DJ-1 in Parkinson's disease<br>Biogerontology (2025) 26, 81-81. PubMed  Europe PubMed DOI  V
  3. Chen,Y., Hu,X., Dou,J., Chen,L. and Zhu,L.<br>DJ-1 protein ameliorates nonalcoholic fatty liver disease via ER-stress pathway and reduces inflammation<br>Biochem Biophys Res Commun (2025) 776, 152175-152175. PubMed  Europe PubMed DOI
  4. Dash,B.K., Urano,Y., Mita,Y., Ashida,Y., Hirose,R. and Noguchi,N.<br>Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex<br>Proc Natl Acad Sci U S A (2025) 122, e2414790122-e2414790122. PubMed  Europe PubMed DOI
  5. Heineman,A., Linck,J., Eylon,A. and Parmar,M.S.<br>Challenges and Opportunities of Early Parkinson's Disease Biomarkers: alpha-Synuclein, Leucine-Rich Repeat Kinase 2 (LRRK2), DJ-1, and microRNAs<br>Cureus (2025) 17, e91510-e91510. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Jiang,M., Wang,M., Wan,L., Li,S., Sun,C., Cao,H., Yu,C. and Lin,J.<br>Inhibition of DJ-1 protects from lupus onset and severity<br>Sci Rep (2025) 15, 31217-31217. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Li,H., Ritsema,Y., Lin,Z., Symasek,A., Wang,Q., Ma,X., Yuan,C. and Zheng,Q.<br>Sirtuin 2 Regulates Histone Glycation as a Semi-deglycase<br>Biochemistry (2025) PubMed  Europe PubMed DOI
  8. Mathas,N., Braud,E., Galardon,E., Larigot,L., Etheve-Quelquejeu,M., Sari,M.A., LE Grand,B., Blanc,E.B., Coumoul,X. and Dairou,J.<br>Park7 (DJ-1), a Parkinson-associated glyoxalase/deglycase: characterization of enzymatic activity in biological samples using fluorescence-based liquid chromatography<br>Biochimie (2025) 235, 113-121. PubMed  Europe PubMed DOI
  9. Wang,H., Guo,Y.M., Yang,J.R., Cao,C., Ren,J.N., Ye,H.Y. and Chen,J.Z.<br>Mechanistic Investigation of Cysteine-Targeted Covalent Inhibition of DJ-1 via MD, QM/MM, and SAPT Computations<br>J Chem Inf Model (2025) PubMed  Europe PubMed DOI
  10. Zhao,A., Ding,Y., Zhong,M., Niu,M., Wang,L., Jiao,Y., Liu,J. and Li,Y.<br>Neuronal DJ-1 regulates microglial activation in Parkinson's disease<br>Neural Regen Res (2025) PubMed  Europe PubMed DOI  K
  11. Zhou,F., Zhou,J.B., Wei,T.P., Wu,D. and Wang,R.X.<br>DJ-1 Serves as a Central Regulator of Diabetes Complications<br>Curr Issues Mol Biol (2025) 47 PubMed  Europe PubMed DOI  PMC  EPMC  V
    12. 2024
  12. Akhmadi,A., Yeskendir,A., Dey,N., Mussakhmetov,A., Shatkenova,Z., Kulyyassov,A., Andreeva,A. and Utepbergenov,D.<br>DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride<br>Nat Commun (2024) 15, 2004-2004. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Bekmagambetov,A., Shkraba,E., Yeskendir,A., Akhmadi,A. and Utepbergenov,D.<br>cPGA hydrolase assay of DJ-1 in crude cell lysates: Implications for sensing of oxidative stress<br>Anal Biochem (2024) 694, 115631-115631. PubMed  Europe PubMed DOI
  14. Dhinesh Kumar,M., Karthikeyan,M., Kaniraja,G., Muthukumar,K., Muneeswaran,G. and Karunakaran,C.<br>Computational modelling and optimization studies of electropentamer for molecular imprinting of DJ-1<br>J Mol Graph Model (2024) 128, 108715-108715. PubMed  Europe PubMed DOI
  15. Ji,Y.W., Wen,X.Y., Tang,H.P., Jin,Z.S., Su,W.T., Zhou,L., Xia,Z.Y., Xia,Z.Y. and Lei,S.Q.<br>DJ-1: Potential target for treatment of myocardial ischemia-reperfusion injury<br>Biomed Pharmacother (2024) 179, 117383-117383. PubMed  Europe PubMed DOI  V
  16. Jia,Y., Oyken,M., Kim,R.Q., Tjokrodirijo,R.T.N., de Ru,A.H., Janssen,A.P.A., Hacker,S.M., van Veelen,P.A., Geurink,P.P. and Sapmaz,A.<br>Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell<br>J Med Chem (2024) 67, 7935-7953-7953. PubMed  Europe PubMed DOI
  17. Li,Y., Liu,X., Li,Y., Wang,J., Zhang,M., Xue,W. and Zhang,M.<br>USP19 exerts a tumor-promoting role in diffuse large B cell lymphoma through stabilizing PARK7<br>FEBS J (2024) 291, 4757-4774. PubMed  Europe PubMed DOI  K
  18. Shih,J.Y. and Hsu,Y.H.<br>Peptide Activator Stabilizes DJ-1 Structure and Enhances Its Activity<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Sun,Y., Chen,S., Grin,I.R., Zharkov,D.O., Yu,B. and Li,H.<br>The dual role of methylglyoxal in plant stress response and regulation of DJ-1 protein<br>Physiol Plant (2024) 176, e14608-e14608. PubMed  Europe PubMed DOI  V
  20. Watanabe,A., Koyano,F., Imai,K., Hizukuri,Y., Ogiwara,S., Ito,T., Miyamoto,J., Shibuya,C., Kimura,M., Toriumi,K., Motono,C., Arai,M., Tanaka,K., Akiyama,Y., Yamano,K. and Matsuda,N.<br>The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA<br>J Biol Chem (2024) , 107476-107476. PubMed  Europe PubMed DOI
  21. Zhang,F., Wan,X., Zhan,J., Shen,M. and Li,R.<br>Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis<br>Front Oncol (2024) 14, 1361152-1361152. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Zielinski,K.A., Dolamore,C., Dalton,K.M., Smith,N., Termini,J., Henning,R., Srajer,V., Hekstra,D.R., Pollack,L. and Wilson,M.A.<br>Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron<br>bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2023
  23. Andrews,T., Seravallic,J. and Powers,R.<br>The reversible low-temperature instability of human DJ-1 oxidative states<br>Biopolymers (2023) , e23534-e23534. PubMed  Europe PubMed DOI
  24. Chavali,L.N.M., Yddal,I., Bifulco,E., Mannsaker,S., Roise,D., Law,J.O., Froyset,A.K., Grellscheid,S.N. and Fladmark,K.E.<br>Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  25. Chien,C.H., Lee,M.J. and Liou,H.C.<br>Growth of B16F10 cells is enhanced in DJ-1-deficiency pancreas<br>Biochem Biophys Res Commun (2023) 682, 359-364. PubMed  Europe PubMed DOI
  26. Cho,N., Joo,J., Choi,S., Kang,B.G., Lee,A.J., Youn,S.Y., Park,S.H., Kim,E.M., Masliah,E., Ko,Y., Cha,S.S., Jung,I. and Kim,K.K.<br>A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction<br>Heliyon (2023) 9, e14039-e14039. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Choi,J., Tak,S., Jung,H.M., Cha,S., Hwang,E., Lee,D., Lee,J.H., Ryu,K.S. and Park,C.<br>Kinetic evidence in favor of glyoxalase III and against deglycase activity of DJ-1<br>Protein Sci (2023) 32, e4641-e4641. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Coukos,J.S., Lee,C.W., Pillai,K.S., Shah,H. and Moellering,R.E.<br>PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function<br>Biochemistry (2023) 62, 3126-3133. PubMed  Europe PubMed DOI  PMC  EPMC
  29. De Lazzari,F., Agostini,F., Plotegher,N., Sandre,M., Greggio,E., Megighian,A., Bubacco,L., Sandrelli,F., Whitworth,A.J. and Bisaglia,M.<br>DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis<br>Neurobiol Dis (2023) 176, 105941-105941. PubMed  Europe PubMed DOI
  30. Fernandes,S.A., Dasgupta,S., Tupe,R.S. and Pathan,E.K.<br>Structure-guided approach to modify the substrate specificity of the protein human deglycase-1 (hDJ-1)<br>Biochem Biophys Res Commun (2023) 679, 122-128. PubMed  Europe PubMed DOI
  31. Lind-Holm Mogensen,F., Scafidi,A., Poli,A. and Michelucci,A.<br>PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target<br>J Neuroinflammation (2023) 20, 95-95. PubMed  Europe PubMed DOI  PMC  EPMC  V
  32. Liu,S., Xu,S., Liu,S. and Chen,H.<br>Importance of DJ-1 in autophagy regulation and disease<br>Arch Biochem Biophys (2023) 743, 109672-109672. PubMed  Europe PubMed DOI
  33. Niere,F., Uneri,A., McArdle,C.J., Deng,Z., Egido-Betancourt,H.X., Cacheaux,L.P., Namjoshi,S.V., Taylor,W.C., Wang,X., Barth,S.H., Reynoldson,C., Penaranda,J., Stierer,M.P., Heaney,C.F., Craft,S., Keene,C.D., Ma,T. and Raab-Graham,K.F.<br>Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease<br>Proc Natl Acad Sci U S A (2023) 120, e2301534120-e2301534120. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Sandrelli,F. and Bisaglia,M.<br>Molecular and Physiological Determinants of Amyotrophic Lateral Sclerosis: What the DJ-1 Protein Teaches Us<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  35. Sun,M.E. and Zheng,Q.<br>The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
    36. 2022
  36. Das,F., Ghosh-Choudhury,N., Maity,S., Kasinath,B.S. and Choudhury,G.G.<br>Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis<br>J Biol Chem (2022) 298, 102246-102246. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Galardon,E., Mathas,N., Padovani,D., Le Corre,L., Poncet,G. and Dairou,J.<br>Persulfidation of DJ-1: Mechanism and Consequences<br>Biomolecules (2022) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  38. Min,H.K., Kim,S.H., Lee,J.Y., Lee,S.H. and Kim,H.R.<br>DJ-1 controls T cell differentiation and osteoclastogenesis in rheumatoid arthritis<br>Sci Rep (2022) 12, 12767-12767. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Neves,M., Graos,M., Anjo,S.I. and Manadas,B.<br>Modulation of signaling pathways by DJ-1: An updated overview<br>Redox Biol (2022) 51, 102283-102283. PubMed  Europe PubMed DOI  PMC  EPMC  V
  40. Zhao,X.Y., Ren,J.M., Liu,H.R., Zhou,T.T., Wang,X.Y., Liu,S. and Chen,H.P.<br>DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury<br>Biochem Biophys Res Commun (2022) 637, 276-285. PubMed  Europe PubMed DOI  K
    41. 2021
  41. Atieh,T.B., Roth,J., Yang,X., Hoop,C.L. and Baum,J.<br>DJ-1 Acts as a Scavenger of alpha-Synuclein Oligomers and Restores Monomeric Glycated alpha-Synuclein<br>Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  42. Chen,X.B., Zhu,H.Y., Bao,K., Jiang,L., Zhu,H., Ying,M.D., He,Q.J., Yang,B., Sheng,R. and Cao,J.<br>Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors<br>Acta Pharmacol Sin (2021) PubMed  Europe PubMed DOI  I
  43. De Lazzari,F., Prag,H.A., Gruszczyk,A.V., Whitworth,A.J. and Bisaglia,M.<br>DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury<br>Redox Biol (2021) 41, 101884-101884. PubMed  Europe PubMed DOI  PMC  EPMC  V
  44. Mencke,P., Boussaad,I., Romano,C.D., Kitami,T., Linster,C.L. and Kruger,R.<br>The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson's Disease<br>Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  45. Sanchez-Lanzas,R. and Castano,J.G.<br>Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants<br>Sci Rep (2021) 11, 7320-7320. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Sircar,E., Rai,S.R., Wilson,M.A., Schlossmacher,M.G. and Sengupta,R.<br>Neurodegeneration: Impact of S-nitrosylated Parkin, DJ-1 and PINK1 on the pathogenesis of Parkinson's disease<br>Arch Biochem Biophys (2021) 704, 108869-108869. PubMed  Europe PubMed DOI  V
  47. Song,I.K., Kim,M.S., Ferrell,J.E., Jr., Shin,D.H. and Lee,K.J.<br>Stepwise oxidations play key roles in the structural and functional regulations of DJ-1<br>Biochem J (2021) 478, 3505-3525. PubMed  Europe PubMed DOI
  48. Tsoporis,J.N., Drosatos,I.A., Gupta,S., Amatullah,H., Izhar,S., Dos Santos,C.C., Salpeas,V., Rigopoulos,A.G., Toumpoulis,I.K., Triantafyllis,A.S., Sakadakis,E., Kavantzas,N., Marshall,J.C., Rizos,I.K. and Parker,T.G.<br>Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology<br>Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC  V
    49. 2020
  49. Almikhlafi,M.A., Stauch,K.L., Villeneuve,L.M., Purnell,P.R., Lamberty,B.G. and Fox,H.S.<br>Deletion of DJ-1 in rats affects protein abundance and mitochondrial function at the synapse<br>Sci Rep (2020) 10, 13719-13719. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Boussaad,I., Obermaier,C.D., Hanss,Z., Bobbili,D.R., Bolognin,S., Glaab,E., Wolynska,K., Weisschuh,N., De Conti,L., May,C., Giesert,F., Grossmann,D., Lambert,A., Kirchen,S., Biryukov,M., Burbulla,L.F., Massart,F., Bohler,J., Cruciani,G., Schmid,B., Kurz-Drexler,A., May,P., Duga,S., Klein,C., Schwamborn,J.C., Marcus,K., Woitalla,D., Vogt Weisenhorn,D.M., Wurst,W., Baralle,M., Krainc,D., Gasser,T., Wissinger,B. and Kruger,R.<br>A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease<br>Sci Transl Med (2020) 12 PubMed  Europe PubMed DOI
  51. Chen,S.M., Chen,T.H., Chang,H.T., Lin,T.Y., Lin,C.Y., Tsai,P.Y., Imai,K., Chen,C.M. and Lee,J.A.<br>Methylglyoxal and D-lactate in cisplatin-induced acute kidney injury: Investigation of the potential mechanism via fluorogenic derivatization liquid chromatography-tandem mass spectrometry (FD-LC-MS/MS) proteomic analysis<br>PLoS ONE (2020) 15, e0235849-e0235849. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Daida,K., Funayama,M., Li,Y., Yoshino,H., Hayashida,A., Ikeda,A., Ogaki,K., Nishioka,K. and Hattori,N.<br>Identification of Disease-Associated Variants by Targeted Gene Panel Resequencing in Parkinson's Disease<br>Front Neurol (2020) 11, 576465-576465. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Ma,J., Wu,R., Zhang,Q., Wu,J.B., Lou,J., Zheng,Z., Ding,J.Q. and Yuan,Z.<br>Correction: DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis<br>Biochem J (2020) 477, 4813-4813. PubMed  Europe PubMed DOI
  54. Ozawa,K., Tsumoto,H., Miura,Y., Yamaguchi,J., Iguchi-Ariga,S.M.M., Sakuma,T., Yamamoto,T. and Uchiyama,Y.<br>DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria<br>Sci Rep (2020) 10, 4377-4377. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Sun,Y., Sun,X., Zhao,L., Zhang,Z., Wang,Y., Dai,Z., Zhao,X. and Pu,X.<br>DJ-1 deficiency causes metabolic abnormality in ornidazole-induced asthenozoospermia<br>Reproduction (2020) 160, 931-941. PubMed  Europe PubMed DOI
  56. Tsai,C.Y., Wu,C.J., Wu,J.C.C., Fang,C., Huang,Y.H. and Dai,K.Y.<br>Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication<br>Neurochem Int (2020) , 104791-104791. PubMed  Europe PubMed DOI
  57. Upadhyay,M., Milliner,C., Bell,B.A. and Bonilha,V.L.<br>Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1<br>Redox Biol (2020) , 101623-101623. PubMed  Europe PubMed DOI
  58. Zhang,L., Wang,J., Wang,J., Yang,B., He,Q. and Weng,Q.<br>Role of DJ-1 in Immune and Inflammatory Diseases<br>Front Immunol (2020) 11, 994-994. PubMed  Europe PubMed DOI  PMC  EPMC  V
    59. 2019
  59. Andreeva,A., Bekkhozhin,Z., Omertassova,N., Baizhumanov,T., Yeltay,G., Akhmetali,M., Toibazar,D. and Utepbergenov,D.<br>The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals<br>J Biol Chem (2019) 294, 18863-18872. PubMed  Europe PubMed DOI  M
  60. Barbieri,L. and Luchinat,E.<br>Backbone resonance assignment of human DJ-1 in the reduced state and in the cysteine sulfinic acid state<br>Biomol NMR Assign (2019) 13, 371-376. PubMed  Europe PubMed DOI  S
  61. Kumar,A., Mukherjee,D. and Satpati,P.<br>Mutations in Parkinson's disease associated protein DJ-1 alter the energetics of DJ-1 dimerization<br>J Chem Inf Model (2019) 59, 1497-1507. PubMed  Europe PubMed DOI  M
  62. Kumar,R., Kumar,S., Hanpude,P., Singh,A.K., Johari,T., Majumder,S. and Maiti,T.K.<br>Partially oxidized DJ-1 inhibits alpha-synuclein nucleation and remodels mature alpha-synuclein fibrils in vitro<br>Commun Biol (2019) 2, 395-395. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Lewandowska,A., Vo,T.N., Nguyen,T.H., Wahni,K., Vertommen,D., Van Breusegem,F., Young,D. and Messens,J.<br>Bifunctional chloroplastic DJ-1B from Arabidopsis thaliana is an oxidation-robust holdase and a glyoxalase sensitive to H(2)O(2)<br>Antioxidants (Basel) (2019) 8 PubMed  Europe PubMed DOI
  64. Pandey,S., Dhusia,K., Katara,P., Singh,S. and Gautam,B.<br>An in silico analysis of deleterious single nucleotide polymorphisms and molecular dynamics simulation of disease linked mutations in genes responsible for neurodegenerative disorder<br>J Biomol Struct Dyn (2019) , 1-14. PubMed  Europe PubMed DOI  M
    65. 2018
  65. Drechsel,J., Mandl,F.A. and Sieber,S.A.<br>Chemical probe to monitor the parkinsonism-associated protein DJ-1 in live cells<br>ACS Chem Biol (2018) 13, 2016-2019. PubMed  Europe PubMed DOI
  66. Mussakhmetov,A., Shumilin,I.A., Nugmanova,R., Shabalin,I.G., Baizhumanov,T., Toibazar,D., Khassenov,B., Minor,W. and Utepbergenov,D.<br>A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1<br>Biochem Biophys Res Commun (2018) 504, 328-333. PubMed  Europe PubMed DOI
  67. Nair,D.N., Prasad,R., Singhal,N., Bhattacharjee,M., Sudhakar,R., Singh,P., Thanumalayan,S., Kiran,U., Sharma,Y. and Sijwali,P.S.<br>A conserved human DJ1-subfamily motif (DJSM) is critical for anti-oxidative and deglycase activities of Plasmodium falciparum DJ1<br>Mol Biochem Parasitol (2018) 222, 70-80. PubMed  Europe PubMed DOI
  68. Strobbe,D., Robinson,A.A., Harvey,K., Rossi,L., Ferraina,C., de Biase,V., Rodolfo,C., Harvey,R.J. and Campanella,M.<br>Distinct mechanisms of pathogenic DJ-1 mutations in mitochondrial quality control<br>Front Mol Neurosci (2018) 11, 68-68. PubMed  Europe PubMed DOI  PMC  EPMC  M
  69. Tashiro,S., Caaveiro,J.M.M., Nakakido,M., Tanabe,A., Nagatoishi,S., Tamura,Y., Matsuda,N., Liu,D., Hoang,Q.Q. and Tsumoto,K.<br>Discovery and optimization of inhibitors of the Parkinson's disease associated protein DJ-1<br>ACS Chem Biol (2018) 13, 2783-2793. PubMed  Europe PubMed DOI  I
    70. 2017
  70. Biosa,A., Sandrelli,F., Beltramini,M., Greggio,E., Bubacco,L. and Bisaglia,M.<br>Recent findings on the physiological function of DJ-1: beyond Parkinson's disease<br>Neurobiol Dis (2017) 108, 65-72. PubMed  Europe PubMed DOI
  71. De Lazzari,F. and Bisaglia,M.<br>DJ-1 as a deglycating enzyme: a unique function to explain a multifaceted protein?<br>Neural Regen Res (2017) 12, 1797-1798. PubMed  Europe PubMed DOI
  72. Fu,K., Wang,Y., Guo,D., Wang,G. and Ren,H.<br>Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2<br>Neurosci Bull (2017) 33, 685-694. PubMed  Europe PubMed DOI  M
  73. Hijioka,M., Inden,M., Yanagisawa,D. and Kitamura,Y.<br>DJ-1/PARK7: a new therapeutic target for neurodegenerative disorders<br>Biol Pharm Bull (2017) 40, 548-552. PubMed  Europe PubMed DOI  M
  74. Kiss,R., Zhu,M., Jojart,B., Czajlik,A., Solti,K., Forizs,B., Nagy,E., Zsila,F., Beke-Somfai,T. and Toth,G.<br>Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease<br>Biochim Biophys Acta (2017) 1861, 2619-2629. PubMed  Europe PubMed DOI
  75. Matsuda,N., Kimura,M., Queliconi,B.B., Kojima,W., Mishima,M., Takagi,K., Koyano,F., Yamano,K., Mizushima,T., Ito,Y. and Tanaka,K.<br>Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro<br>Sci Rep (2017) 7, 12816-12816. PubMed  Europe PubMed DOI  PMC  EPMC
  76. Pfaff,D.H., Fleming,T., Nawroth,P. and Teleman,A.A.<br>Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification<br>J Biol Chem (2017) 292, 685-690. PubMed  Europe PubMed DOI
  77. Richarme,G. and Dairou,J.<br>Parkinsonism-associated protein DJ-1 is a bona fide deglycase<br>Biochem Biophys Res Commun (2017) 483, 387-391. PubMed  Europe PubMed DOI
    78. 2016
  78. Fernandez-Caggiano,M., Schroder,E., Cho,H.J., Burgoyne,J., Barallobre-Barreiro,J., Mayr,M. and Eaton,P.<br>Oxidant-induced Interprotein disulfide formation in cardiac protein DJ-1 occurs via an interaction with peroxiredoxin 2<br>J Biol Chem (2016) 291, 10399-10410. PubMed  Europe PubMed DOI
  79. Richarme,G., Marguet,E., Forterre,P., Ishino,S. and Ishino,Y.<br>DJ-1 family Maillard deglycases prevent acrylamide formation<br>Biochem Biophys Res Commun (2016) 478, 1111-1116. PubMed  Europe PubMed DOI
  80. Vazquez-Mayorga,E., Diaz-Sanchez,A.G., Dagda,R.K., Dominguez-Solis,C.A., Dagda,R.Y., Coronado-Ramirez,C.K. and Martinez-Martinez,A.<br>Novel redox-dependent esterase activity (EC 3.1.1.2) for DJ-1: implications for Parkinson's disease<br>Int J Mol Sci (2016) 17 PubMed  Europe PubMed DOI  PMC  EPMC
    81. 2015
  81. Milkovic,N.M., Catazaro,J., Lin,J., Halouska,S., Kizziah,J.L., Basiaga,S., Cerny,R.L., Powers,R. and Wilson,M.A.<br>Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature<br>Protein Sci (2015) 24, 1671-1685. PubMed  Europe PubMed DOI  PMC  EPMC  S
  82. Moscovitz,O., Ben-Nissan,G., Fainer,I., Pollack,D., Mizrachi,L. and Sharon,M.<br>The Parkinson's-associated protein DJ-1 regulates the 20S proteasome<br>Nat Commun (2015) 6, 6609-6609. PubMed  Europe PubMed DOI
  83. Richarme,G., Mihoub,M., Dairou,J., Bui,L.C., Leger,T. and Lamouri,A.<br>Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues<br>J Biol Chem (2015) 290, 1885-1897. PubMed  Europe PubMed DOI
    84. 2014
  84. Prahlad,J., Hauser,D.N., Milkovic,N.M., Cookson,M.R. and Wilson,M.A.<br>Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers<br>J Neurochem (2014) 130, 839-853. PubMed  Europe PubMed DOI
  85. Tashiro,S., Caaveiro,J.M., Wu,C.X., Hoang,Q.Q. and Tsumoto,K.<br>Thermodynamic and structural characterization of the specific binding of Zn(II) to human protein DJ-1<br>Biochemistry (2014) 53, 2218-2220. PubMed  Europe PubMed DOI
    86. 2013
  86. Hwang,S., Song,S., Hong,Y.K., Choi,G., Suh,Y.S., Han,S.Y., Lee,M., Park,S.H., Lee,J.H., Lee,S., Bang,S.M., Jeong,Y., Chung,W.J., Lee,I.S., Jeong,G., Chung,J. and Cho,K.S.<br>Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO<br>PLoS Genet (2013) 9, e1003412-e1003412. PubMed  Europe PubMed DOI  PMC  EPMC
  87. Li,B., Yu,D. and Xu,Z.<br>Edaravone prevents neurotoxicity of mutant L166P DJ-1 in Parkinson's disease<br>J Mol Neurosci (2013) 51, 539-549. PubMed  Europe PubMed DOI  M
  88. Maita,C., Maita,H., Iguchi-Ariga,S.M. and Ariga,H.<br>Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants<br>PLoS ONE (2013) 8, e54087-e54087. PubMed  Europe PubMed DOI  PMC  EPMC
  89. Mitsugi,H., Niki,T., Takahashi-Niki,K., Tanimura,K., Yoshizawa-Kumagaye,K., Tsunemi,M., Iguchi-Ariga,S.M. and Ariga,H.<br>Identification of the recognition sequence and target proteins for DJ-1 protease<br>FEBS Lett (2013) 587, 2493-2499. PubMed  Europe PubMed DOI  P
    90. 2012
  90. Girotto,S., Sturlese,M., Bellanda,M., Tessari,I., Cappellini,R., Bisaglia,M., Bubacco,L. and Mammi,S.<br>Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53<br>J Biol Chem (2012) 287, 18738-18749. PubMed  Europe PubMed DOI
  91. Jung,H.J., Kim,S., Kim,Y.J., Kim,M.K., Kang,S.G., Lee,J.H., Kim,W. and Cha,S.S.<br>Dissection of the dimerization modes in the DJ-1 superfamily<br>Mol Cells (2012) 33, 163-171. PubMed  Europe PubMed DOI
  92. Lee,J.Y., Song,J., Kwon,K., Jang,S., Kim,C., Baek,K., Kim,J. and Park,C.<br>Human DJ-1 and its homologs are novel glyoxalases<br>Hum Mol Genet (2012) 21, 3215-3225. PubMed  Europe PubMed DOI
  93. Lin,J., Prahlad,J. and Wilson,M.A.<br>Conservation of oxidative protein stabilization in an insect homologue of Parkinsonism-associated protein DJ-1<br>Biochemistry (2012) 51, 3799-3807. PubMed  Europe PubMed DOI
  94. Madzelan,P., Labunska,T. and Wilson,M.A.<br>Influence of peptide dipoles and hydrogen bonds on reactive cysteine pKa values in fission yeast DJ-1<br>FEBS J (2012) 279, 4111-4120. PubMed  Europe PubMed DOI
  95. Stefanatos,R., Sriram,A., Kiviranta,E., Mohan,A., Ayala,V., Jacobs,H.T., Pamplona,R. and Sanz,A.<br>dj-1beta regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster<br>Cell Cycle (2012) 11, 3876-3886. PubMed  Europe PubMed DOI
    96. 2011
  96. Lin,J., Nazarenus,T.J., Frey,J.L., Liang,X., Wilson,M.A. and Stone,J.M.<br>A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development<br>PLoS ONE (2011) 6, e23731-e23731. PubMed  Europe PubMed DOI  PMC  EPMC
  97. Wilson,M.A.<br>The role of cysteine oxidation in DJ-1 function and dysfunction<br>Antioxid Redox Signal (2011) 15, 111-122. PubMed  Europe PubMed DOI
    98. 2010
  98. Chen,J., Li,L. and Chin,L.S.<br>Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage<br>Hum Mol Genet (2010) 19, 2395-2408. PubMed  Europe PubMed DOI
  99. Giaime,E., Sunyach,C., Druon,C., Scarzello,S., Robert,G., Grosso,S., Auberger,P., Goldberg,M.S., Shen,J., Heutink,P., Pouyssegur,J., Pages,G., Checler,F. and Alves da Costa,C.<br>Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6<br>Cell Death Differ (2010) 17, 158-169. PubMed  Europe PubMed DOI
  100. Ramsey,C.P. and Giasson,B.I.<br>L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments<br>J Neurosci Res (2010) 88, 3111-3124. PubMed  Europe PubMed DOI
    101. 2008
  101. Lakshminarasimhan,M., Maldonado,M.T., Zhou,W., Fink,A.L. and Wilson,M.A.<br>Structural impact of three Parkinsonism-associated missense mutations on human DJ-1<br>Biochemistry (2008) 47, 1381-1392. PubMed  Europe PubMed DOI  PMC  EPMC  M  S
    102. 2007
  102. Koide-Yoshida,S., Niki,T., Ueda,M., Himeno,S., Taira,T., Iguchi-Ariga,S.M., Ando,Y. and Ariga,H.<br>DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy<br>Int J Mol Med (2007) 19, 885-893. PubMed  Europe PubMed
  103. Zhang,D., Lim,S.G. and Koay,E.S.<br>Proteomic identification of down-regulation of oncoprotein DJ-1 and proteasome activator subunit 1 in hepatitis B virus-infected well-differentiated hepatocellular carcinoma<br>Int J Oncol (2007) 31, 577-584. PubMed  Europe PubMed
    104. 2006
  104. Gosal,D., Ross,O.A. and Toft,M.<br>Parkinson's disease: the genetics of a heterogeneous disorder<br>Eur J Neurol (2006) 13, 616-627. PubMed  Europe PubMed DOI
  105. Sekito,A., Koide-Yoshida,S., Niki,T., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.<br>DJ-1 interacts with HIPK1 and affects H2O2-induced cell death<br>Free Radic Res (2006) 40, 155-165. PubMed  Europe PubMed DOI
    106. 2004
  106. [YEAR:19-2-2004]Bandyopadhyay,S. and Cookson,M.R.<br>Evolutionary and functional relationships within the DJ1 superfamily<br>BMC Evol Biol (19-2-2004) 4, 6-6. PubMed  Europe PubMed DOI  PMC  EPMC
  107. [YEAR:8-1-2004]Bonifati,V., Oostra,B.A. and Heutink,P.<br>Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease<br>J Mol Med (8-1-2004) 82, 163-174. PubMed  Europe PubMed DOI
  108. Hicks,P.M., Chang,L.S. and Kelly,R.M.<br>Pyrococcus furiosus protease I<br>[ISSN:0-12-079610-4] (2004) 2, 1393-1395.  V
  109. [YEAR:9-12-2004]Olzmann,J.A., Brown,K., Wilkinson,K.D., Rees,H.D., Huai,Q., Ke,H., Levey,A.I., Li,L. and Chin,L.S.<br>Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function<br>J Biol Chem (9-12-2004) 279, 8506-8515. PubMed  Europe PubMed DOI
  110. Rizzu,P., Hinkle,D.A., Zhukareva,V., Bonifati,V., Severijnen,L.A., Martinez,D., Ravid,R., Kamphorst,W., Eberwine,J.H., Lee,V.M., Trojanowski,J.Q. and Heutink,P.<br>DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia<br>Ann Neurol (2004) 55, 113-118. PubMed  Europe PubMed DOI
  111. [YEAR:23-7-2004]Takahashi-Niki,K., Niki,T., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.<br>Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients<br>Biochem Biophys Res Commun (23-7-2004) 320, 389-397. PubMed  Europe PubMed DOI
    112. 2003
  112. Hague,S., Rogaeva,E., Hernandez,D., Gulick,C., Singleton,A., Hanson,M., Johnson,J., Weiser,R., Gallardo,M., Ravina,B., Gwinn-Hardy,K., Crawley,A., St George-Hyslop,P.H., Lang,A.E., Heutink,P., Bonifati,V., Hardy,J. and Singleton,A.<br>Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation<br>Ann Neurol (2003) 54, 271-274. PubMed  Europe PubMed DOI
  113. [YEAR:7-11-2003]Lee,S.J., Kim,S.J., Kim,I.K., Ko,J., Jeong,C.S., Kim,G.H., Park,C., Kang,S.O., Suh,P.G., Lee,H.S. and Cha,S.S.<br>Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain<br>J Biol Chem (7-11-2003) 278, 44552-44559. PubMed  Europe PubMed DOI  S
    114. 2001
  114. [YEAR:24-1-2001]Taira,T., Takahashi,K., Kitagawa,R., Iguchi-Ariga,S.M. and Ariga,H.<br>Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter<br>Gene (24-1-2001) 263, 285-292. PubMed  Europe PubMed DOI
  115. [YEAR:5-10-2001]Takahashi,K., Taira,T., Niki,T., Seino,C., Iguchi-Ariga,S.M. and Ariga,H.<br>DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor<br>J Biol Chem (5-10-2001) 276, 37556-37563. PubMed  Europe PubMed DOI
    116. 2000
  116. Wagenfeld,A., Yeung,C.H., Shivaji,S., Sundareswaran,V.R., Ariga,H. and Cooper,T.G.<br>Expression and cellular localization of contraception-associated protein<br>J Androl (2000) 21, 954-963. PubMed  Europe PubMed
    117. 1999
  117. [YEAR:1-3-1999]Hod,Y., Pentyala,S.N., Whyard,T.C. and El-Maghrabi,M.R.<br>Identification and characterization of a novel protein that regulates RNA-protein interaction<br>J Cell Biochem (1-3-1999) 72, 435-444. PubMed  Europe PubMed DOI
    118. 1998
  118. [YEAR:20-10-1998]Wagenfeld,A., Gromoll,J. and Cooper,T.G.<br>Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization<br>Biochem Biophys Res Commun (20-10-1998) 251, 545-549. PubMed  Europe PubMed DOI
    119. 1997
  119. [YEAR:13-2-1997]Nagakubo,D., Taira,T., Kitaura,H., Ikeda,M., Tamai,K., Iguchi-Ariga,S.M. and Ariga,H.<br>DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras<br>Biochem Biophys Res Commun (13-2-1997) 231, 509-513. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use