Literature for peptidase C54.001: ATG4 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Actis Dato,V., Fujita,K. and Lange,S.
    Novel links of ATG4 proteases to cytoskeletal adapters of the obscurin protein family
    Autophagy (2025) , 1-3. PubMed  Europe PubMed DOI
  2. 2024
  3. Li,H., Song,J.Z., He,C.W., Xie,M.X., Zhang,Z.T., Zhou,Y., Li,X.J., Cui,L., Zhu,J., Gong,Q. and Xie,Z.
    Temporal dissection of the roles of Atg4 and ESCRT in autophagosome formation in yeast
    Cell Death Differ (2024) PubMed  Europe PubMed DOI
  4. 2022
  5. Hiura,F., Kawabata,Y., Aoki,T., Mizokami,A. and Jimi,E.
    Inhibition of the ATG4-LC3 pathway suppressed osteoclast maturation
    Biochem Biophys Res Commun (2022) 632, 40-47. PubMed  Europe PubMed DOI
  6. 2021
  7. Ketteler,R. and Tooze,S.A.
    ATG4: More Than a Protease?
    Trends Cell Biol (2021) 31, 515-516. PubMed  Europe PubMed DOI
  8. Viret,C. and Faure,M.
    Lipidation status of single membrane-associated ATG8 proteins
    Trends Biochem Sci (2021) PubMed  Europe PubMed DOI
  9. Xia,F., Liu,P. and Li,M.
    The regulatory factors and pathological roles of autophagy-related protein 4 in diverse diseases: Recent research advances
    Med Res Rev (2021) 41, 1644-1675. PubMed  Europe PubMed DOI
  10. 2020
  11. Roberto,T.N., Lima,R.F., Pascon,R.C., Idnurm,A. and Vallim,M.A.
    Biological functions of the autophagy-related proteins Atg4 and Atg8 in Cryptococcus neoformans
    PLoS ONE (2020) 15, e0230981-e0230981. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Zhou,D., Xie,M., Bai,N., Yang,L., Zhang,K.Q. and Yang,J.
    The Autophagy-Related Gene Aolatg4 Regulates Hyphal Growth, Sporulation, Autophagosome Formation, and Pathogenicity in Arthrobotrys oligospora
    Front Microbiol (2020) 11, 592524-592524. PubMed  Europe PubMed DOI  PMC  EPMC
  13. 2019
  14. Herhaus,L., Bhaskara,R.M., Lystad,A.H., Gestal-Mato,U., Covarrubias-Pinto,A., Bonn,F., Simonsen,A., Hummer,G. and Dikic,I.
    TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease
    EMBO Rep (2019) , e48317-e48317. PubMed  Europe PubMed DOI
  15. Liu,N., Ren,W., Li,F., Chen,C. and Ma,Z.
    Involvement of the cysteine protease BcAtg4 in development and virulence of Botrytis cinerea
    Curr Genet (2019) 65, 293-300. PubMed  Europe PubMed DOI
  16. 2018
  17. Liu,P.F., Tsai,K.L., Hsu,C.J., Tsai,W.L., Cheng,J.S., Chang,H.W., Shiau,C.W., Goan,Y.G., Tseng,H.H., Wu,C.H., Reed,J.C., Yang,L.W. and Shu,C.W.
    Drug repurposing screening identifies tioconazole as an ATG4 inhibitor that suppresses autophagy and sensitizes cancer cells to chemotherapy
    Theranostics (2018) 8, 830-845. PubMed  Europe PubMed DOI  PMC  EPMC  I
  18. 2017
  19. Abreu,S., Kriegenburg,F., Gomez-Sanchez,R., Mari,M., Sanchez-Wandelmer,J., Skytte Rasmussen,M., Soares Guimaraes,R., Zens,B., Schuschnig,M., Hardenberg,R., Peter,M., Johansen,T., Kraft,C., Martens,S. and Reggiori,F.
    Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation
    EMBO Rep (2017) 18, 765-780. PubMed  Europe PubMed DOI
  20. Li,M., Fu,Y., Yang,Z. and Yin,X.-M.
    Measurement of the activity of the Atg4 cysteine proteases
    Methods Enzymol (2017) 587, 207-225. DOI  A
  21. Lopez-Otin,C. and Marino,G.
    Tagged ATG8-coding constructs for the in vitro and in vivo assessment of ATG4 activity
    Methods Enzymol (2017) 587, 189-205. PubMed  Europe PubMed DOI  A
  22. Maruyama,T. and Noda,N.N.
    Autophagy-regulating protease Atg4: structure, function, regulation and inhibition
    J Antibiot (Tokyo) (2017) 71, 72-78. PubMed  Europe PubMed DOI
  23. Morishita,H., Kaizuka,T., Hama,Y. and Mizushima,N.
    A new probe to measure autophagic flux in vitro and in vivo
    Autophagy (2017) 13, 757-758. PubMed  Europe PubMed DOI
  24. Sanchez-Wandelmer,J., Kriegenburg,F., Rohringer,S., Schuschnig,M., Gomez-Sanchez,R., Zens,B., Abreu,S., Hardenberg,R., Hollenstein,D., Gao,J., Ungermann,C., Martens,S., Kraft,C. and Reggiori,F.
    Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
    Nat Commun (2017) 8, 295-295. PubMed  Europe PubMed DOI  PMC  EPMC
  25. 2016
  26. Seo,E., Woo,J., Park,E., Bertolani,S.J., Siegel,J.B., Choi,D. and Dinesh-Kumar,S.P.
    Comparative analyses of ubiquitin-like ATG8 and cysteine protease ATG4 autophagy genes in the plant lineage and cross-kingdom processing of ATG8 by ATG4
    Autophagy (2016) 12, 2054-2068. PubMed  Europe PubMed DOI  P
  27. 2014
  28. Frey,S. and Gorlich,D.
    A new set of highly efficient, tag-cleaving proteases for purifying recombinant proteins
    J Chromatogr A (2014) 1337, 95-105. PubMed  Europe PubMed DOI  P
  29. Frey,S. and Gorlich,D.
    Purification of protein complexes of defined subunit stoichiometry using a set of orthogonal, tag-cleaving proteases
    J Chromatogr A (2014) 1337, 106-115. PubMed  Europe PubMed DOI  P
  30. Perez-Perez,M.E., Zaffagnini,M., Marchand,C.H., Crespo,J.L. and Lemaire,S.D.
    The yeast autophagy protease Atg4 is regulated by thioredoxin
    Autophagy (2014) 10, 1953-1964. PubMed  Europe PubMed DOI
  31. 2013
  32. Lopez-Alonso,I., Aguirre,A., Gonzalez-Lopez,A., Fernandez,A.F., Amado-Rodriguez,L., Astudillo,A., Batalla-Solis,E. and Albaiceta,G.M.
    Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NF-kappaB pathway
    Am J Physiol Lung Cell Mol Physiol (2013) 304, L844-L852. PubMed  Europe PubMed DOI  K
  33. Nakatogawa,H.
    Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy
    Essays Biochem (2013) 55, 39-50. PubMed  Europe PubMed DOI
  34. 2012
  35. Li,M., Chen,X., Ye,Q.Z., Vogt,A. and Yin,X.M.
    A high-throughput FRET-based assay for determination of Atg4 activity
    Autophagy (2012) 8, 401-412. PubMed  Europe PubMed DOI  A
  36. Li,Y., Luo,Q., Yuan,L., Miao,C., Mu,X., Xiao,W., Li,J., Sun,T. and Ma,E.
    JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells
    Toxicol Appl Pharmacol (2012) 263, 21-31. PubMed  Europe PubMed DOI
  37. Nakatogawa,H., Ishii,J., Asai,E. and Ohsumi,Y.
    Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis
    Autophagy (2012) 8, 177-186. PubMed  Europe PubMed DOI
  38. Nakatogawa,H. and Ohsumi,Y.
    ATG4 proteases in autophagy
    [ISSN:978-0-12-407743-0] (2012) 3, 2138-2142. DOI
  39. 2011
  40. Choi,K.M., Nam,H.Y., Na,J.H., Kim,S.W., Kim,S.Y., Kim,K., Kwon,I.C. and Ahn,H.J.
    A monitoring method for Atg4 activation in living cells using peptide-conjugated polymeric nanoparticles
    Autophagy (2011) 7, 1052-1062. PubMed  Europe PubMed DOI
  41. 2010
  42. Filomeni,G., Desideri,E., Cardaci,S., Rotilio,G. and Ciriolo,M.R.
    Under the ROS thiol network is the principal suspect for autophagy commitment
    Autophagy (2010) 6, 999-1005. PubMed  Europe PubMed DOI
  43. Liu,T.B., Liu,X.H., Lu,J.P., Zhang,L., Min,H. and Lin,F.C.
    The cysteine protease MoAtg4 interacts with MoAtg8 and is required for differentiation and pathogenesis in Magnaporthe oryzae
    Autophagy (2010) 6, 74-85. PubMed  Europe PubMed DOI
  44. 2007
  45. Scherz-Shouval,R., Shvets,E., Fass,E., Shorer,H., Gil,L. and Elazar,Z.
    Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    EMBO J (2007) 26, 1749-1760. PubMed  Europe PubMed DOI  PMC  EPMC
  46. 2004
  47. Kirisako,T. and Ohsumi,Y.
    The yeast Apg4/Aut2 protease in autophagy
    [ISSN:0-12-079610-4] (2004) 2, 1243-1245.  V
  48. 2003
  49. Klionsky,D.J., Cregg,J.M., Dunn,W.A., Jr., Emr,S.D., Sakai,Y., Sandoval,I.V., Sibirny,A., Subramani,S., Thumm,M., Veenhuis,M. and Ohsumi,Y.
    A unified nomenclature for yeast autophagy-related genes
    Dev Cell (2003) 5, 539-545. PubMed  Europe PubMed DOI
  50. 2000
  51. Kirisako,T., Ichimura,Y., Okada,H., Kabeya,Y., Mizushima,N., Yoshimori,T., Ohsumi,M., Takao,T., Noda,T. and Ohsumi,Y.
    The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway
    J Cell Biol (2000) 151, 263-276. PubMed  Europe PubMed DOI  PMC  EPMC