Literature for peptidase C50.002: separase (Homo sapiens-type)

(Topics flags: A Assay, M Mutation, K Knockout, P Specificity, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024
1. Picotto,J., Cipressa,F., Busso,D., Cenci,G., Bertrand,P. and Pennarun,G.
   Lamin B1-dependent regulation of human separase in mitosis
   bioRxiv PubMed  Europe PubMed DOI
2. Zhu,Q., Du,L., Wu,J., Li,J. and Lin,Z.
   Walrycin B, as a novel separase inhibitor, exerts potent anticancer efficacy in a mouse xenograft model
   Biochem Pharmacol229, 116502-116502. PubMed  Europe PubMed DOI  I
2023
3. Konecna,M., Abbasi Sani,S. and Anger,M.
   Separase and Roads to Disengage Sister Chromatids during Anaphase
   Int J Mol Sci24, PubMed  Europe PubMed DOI  V
4. Yu,J., Morgan,D.O. and Boland,A.
   The molecular mechanisms of human separase regulation
   Biochem Soc Trans51, 1225-1233. PubMed  Europe PubMed DOI
2022
5. Boukaba,A., Wu,Q., Liu,J., Chen,C., Liang,J., Li,J. and Strunnikov,A.V.
   Mapping separase-mediated cleavage in situ
   NAR Genom Bioinform4, lqac085-lqac085. PubMed  Europe PubMed DOI
6. Chen,J., Gao,C., Luo,M., Zheng,C., Lin,X., Ning,Y., Ma,L., He,W., Xie,D., Liu,K., Hong,K. and Han,C.
   MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage
   EMBO Rep23, e54298-e54298. PubMed  Europe PubMed DOI
7. Nikalayevich,E., El Jailani,S., Dupre,A., Cladiere,D., Gryaznova,Y., Fosse,C., Buffin,E., Touati,S.A. and Wassmann,K.
   Aurora B/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes
   Curr Biol32, 2281-2290. PubMed  Europe PubMed DOI
8. Nikalayevich,E. and Wassmann,K.
   Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor
   STAR Protoc3, 101714-101714. PubMed  Europe PubMed DOI
9. Shindo,N., Kumada,K., Iemura,K., Yasuda,J., Fujimori,H., Mochizuki,M., Tamai,K., Tanaka,K. and Hirota,T.
   Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1
   Cell Rep41, 111723-111723. PubMed  Europe PubMed DOI
10. Vijayakumari,D., Muller,J. and Hauf,S.
    Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase
    Cell Rep38, 110554-110554. PubMed  Europe PubMed DOI
11. Wassmann,K.
    Separase Control and Cohesin Cleavage in Oocytes: Should I Stay or Should I Go?
    Cells11, PubMed  Europe PubMed DOI  V
12. Zhou,C.J., Wang,X.Y., Dong,Y.H., Wang,D.H., Han,Z., Zhang,X.J., Sun,Q.Y., Carroll,J. and Liang,C.G.
    CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I
    Nat Commun13, 7732-7732. PubMed  Europe PubMed DOI
2021
13. Aouadi,E., Fornier,M., Gosseye,A., Castillo-Ferrer,C. and Frachet,V.
    [Separase, a key-player of mitosis: A new target for cancer therapy?]
    Med Sci (Paris)37, 684-686. PubMed  Europe PubMed DOI
14. Li,J., Zhang,H.Y., Wang,F., Sun,Q.Y. and Qian,W.P.
    The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II
    Front Cell Dev Biol9, 648053-648053. PubMed  Europe PubMed DOI
15. Maier,N.K., Ma,J., Lampson,M.A. and Cheeseman,I.M.
    Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition
    Dev Cell56, 2192-2206. PubMed  Europe PubMed DOI
16. Raia,P., Yu,J. and Boland,A.
    Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1
    Mol Cell Oncol8, 1975473-1975473. PubMed  Europe PubMed DOI
2020
17. Hellmuth,S., Gomez-H,L., Pendas,A.M. and Stemmann,O.
    Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2
    Nature580, 536-541. PubMed  Europe PubMed DOI  I
18. Hellmuth,S. and Stemmann,O.
    Separase-triggered apoptosis enforces minimal length of mitosis
    Nature580, 542-547. PubMed  Europe PubMed DOI
19. Spiess,B., Kleiner,H., Flach,J., Fabarius,A., Saussele,S., Hofmann,W.K. and Seifarth,W.
    Separase activity distribution can be a marker of major molecular response and proliferation of CD34(+) cells in TKI-treated chronic myeloid leukemia patients
    Ann Hematol99, 991-1006. PubMed  Europe PubMed DOI
2019
20. Henschke,L., Frese,M., Hellmuth,S., Marx,A., Stemmann,O. and Mayer,T.U.
    Identification of bioactive small molecule inhibitors of separase
    ACS Chem Biol14, 2155-2159. PubMed  Europe PubMed DOI  A  I
21. Rosen,L.E., Klebba,J.E., Asfaha,J.B., Ghent,C.M., Campbell,M.G., Cheng,Y. and Morgan,D.O.
    Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
    Nat Commun10, 5189-5189. PubMed  Europe PubMed DOI  P
2018
22. Cucco,F., Palumbo,E., Camerini,S., D'Alessio,B., Quarantotti,V., Casella,M.L., Rizzo,I.M., Cukrov,D., Delia,D., Russo,A., Crescenzi,M. and Musio,A.
    Separase prevents genomic instability by controlling replication fork speed
    Nucleic Acids Res46, 267-278. PubMed  Europe PubMed DOI
23. Hellmuth,S., Gutierrez-Caballero,C., Llano,E., Pendas,A.M. and Stemmann,O.
    Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation
    EMBO J37, e99184-e99184. PubMed  Europe PubMed DOI
24. Luo,S. and Tong,L.
    Structural biology of the separase-securin complex with crucial roles in chromosome segregation
    Curr Opin Struct Biol49, 114-122. PubMed  Europe PubMed DOI  V
25. Nikalayevich,E., Bouftas,N. and Wassmann,K.
    Detection of separase activity using a cleavage sensor in live mouse oocytes
    Methods Mol Biol1818, 99-112. PubMed  Europe PubMed DOI  L
26. Revinski,D.R., Zaragosi,L.E., Boutin,C., Ruiz-Garcia,S., Deprez,M., Thome,V., Rosnet,O., Gay,A.S., Mercey,O., Paquet,A., Pons,N., Ponzio,G., Marcet,B., Kodjabachian,L. and Barbry,P.
    CDC20B is required for deuterosome-mediated centriole production in multiciliated cells
    Nat Commun9, 4668-4668. PubMed  Europe PubMed DOI
27. Ruppenthal,S., Kleiner,H., Nolte,F., Fabarius,A., Hofmann,W.K., Nowak,D. and Seifarth,W.
    Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS
    PLoS ONE13, e0191734-e0191734. PubMed  Europe PubMed DOI
2017
28. Kumar,R.
    Separase: function beyond cohesion cleavage and an emerging oncogene
    J Cell Biochem118, 1283-1299. PubMed  Europe PubMed DOI  V
29. Zhang,N. and Pati,D.
    Biology and insights into the role of cohesin protease separase in human malignancies
    Biol Rev Camb Philos Soc92, 2070-2083. PubMed  Europe PubMed DOI
2016
30. Agircan,F.G., Hata,S., Nussbaum-Krammer,C., Atorino,E. and Schiebel,E.
    Proximity mapping of human separase by the BioID approach
    Biochem Biophys Res Commun478, 656-662. PubMed  Europe PubMed DOI
31. Do,H.T., Zhang,N., Pati,D. and Gilbertson,S.R.
    Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase
    Bioorg Med Chem Lett26, 4446-4450. PubMed  Europe PubMed DOI  I
2015
32. Haass,W., Kleiner,H., Weiss,C., Haferlach,C., Schlegelberger,B., Muller,M.C., Hehlmann,R., Hofmann,W.K., Fabarius,A. and Seifarth,W.
    Clonal evolution and blast crisis correlate with enhanced proteolytic activity of separase in BCR-ABL b3a2 fusion type CML under imatinib therapy
    PLoS ONE10, e0129648-e0129648. PubMed  Europe PubMed DOI
33. Haass,W., Kleiner,H., Muller,M.C., Hofmann,W.K., Fabarius,A. and Seifarth,W.
    Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay
    PLoS ONE10, e0133769-e0133769. PubMed  Europe PubMed DOI  A  L
34. Hellmuth,S., Rata,S., Brown,A., Heidmann,S., Novak,B. and Stemmann,O.
    Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1
    Mol Cell58, 495-506. PubMed  Europe PubMed DOI
35. Hellmuth,S., Pohlmann,C., Brown,A., Bottger,F., Sprinzl,M. and Stemmann,O.
    Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable
    J Biol Chem290, 8002-8010. PubMed  Europe PubMed DOI
2014
36. Agircan,F.G. and Schiebel,E.
    Sensors at centrosomes reveal determinants of local separase activity
    PLoS Genet10, e1004672-e1004672. PubMed  Europe PubMed DOI  L
37. Hellmuth,S., Bottger,F., Pan,C., Mann,M. and Stemmann,O.
    PP2A delays APC/C-dependent degradation of separase-associated but not free securin
    EMBO J33, 1134-1147. PubMed  Europe PubMed DOI
38. Mukherjee,M., Ge,G., Zhang,N., Edwards,D.G., Sumazin,P., Sharan,S.K., Rao,P.H., Medina,D. and Pati,D.
    MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERalpha)-positive mammary adenocarcinomas
    Oncogene33, 5511-5522. PubMed  Europe PubMed DOI
39. Mukherjee,M., Byrd,T., Brawley,V.S., Bielamowicz,K., Li,X.N., Merchant,F., Maitra,S., Sumazin,P., Fuller,G., Kew,Y., Sun,D., Powell,S.Z., Ahmed,N.M., Zhang,N. and Pati,D.
    Overexpression and constitutive nuclear localization of cohesin protease separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme
    J Neurooncol119, 27-35. PubMed  Europe PubMed DOI
40. Zhang,N., Scorsone,K., Ge,G., Kaffes,C.C., Dobrolecki,L.E., Mukherjee,M., Lewis,M.T., Berg,S., Stephan,C.C. and Pati,D.
    Identification and characterization of separase inhibitors (sepins) for cancer therapy
    J Biomol Screen19, 878-889. PubMed  Europe PubMed DOI  I
2013
41. Han,X. and Poon,R.Y.
    Critical differences between isoforms of securin reveal mechanisms of separase regulation
    Mol Cell Biol33, 3400-3415. PubMed  Europe PubMed DOI
2012
42. Haass,W., Stehle,M., Nittka,S., Giehl,M., Schrotz-King,P., Fabarius,A., Hofmann,W.K. and Seifarth,W.
    The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib
    PLoS ONE7, e42863-e42863. PubMed  Europe PubMed DOI
43. Peters,J.M. and Nasmyth,K.
    Separase
    [ISSN:978-0-12-407743-0]3, 2344-2350. DOI
2011
44. Bacac,M., Fusco,C., Planche,A., Santodomingo,J., Demaurex,N., Leemann-Zakaryan,R., Provero,P. and Stamenkovic,I.
    Securin and separase modulate membrane traffic by affecting endosomal acidification
    Traffic12, 615-626. PubMed  Europe PubMed DOI
45. Chiang,T., Schultz,R.M. and Lampson,M.A.
    Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes
    Biol Reprod85, 1279-1283. PubMed  Europe PubMed DOI
46. Mukherjee,M., Ge,G., Zhang,N., Huang,E., Nakamura,L.V., Minor,M., Fofanov,V., Rao,P.H., Herron,A. and Pati,D.
    Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice
    PLoS ONE6, e22167-e22167. PubMed  Europe PubMed DOI  K
47. Xu,J., Wang,M., Gao,X., Hu,B., Du,Y., Zhou,J., Tian,X. and Huang,X.
    Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis
    PLoS ONE6, e18763-e18763. PubMed  Europe PubMed DOI
48. Yang,X., Boateng,K.A., Yuan,L., Wu,S., Baskin,T.I. and Makaroff,C.A.
    The Radially Swollen 4 separase mutation of Arabidopsis thaliana blocks chromosome disjunction and disrupts the radial microtubule system in meiocytes
    PLoS ONE6, e19459-e19459. PubMed  Europe PubMed DOI  M
2010
49. Wardlaw,C.P.
    Protein phosphatase 2A contributes to separase regulation and the co-ordination of anaphase
    Biosci Horiz3, 66-76. DOI
2009
50. Basu,D., Zhang,N., Panigrahi,A.K., Horton,T.M. and Pati,D.
    Development and validation of a fluorogenic assay to measure separase enzyme activity
    Anal Biochem392, 133-138. PubMed  Europe PubMed DOI  A
51. Huang,X., Andreu-Vieyra,C.V., Wang,M., Cooney,A.J., Matzuk,M.M. and Zhang,P.
    Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation
    Mol Cell Biol29, 1498-1505. PubMed  Europe PubMed DOI
52. Kudo,N.R., Anger,M., Peters,A.H., Stemmann,O., Theussl,H.C., Helmhart,W., Kudo,H., Heyting,C. and Nasmyth,K.
    Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I
    J Cell Sci122, 2686-2698. PubMed  Europe PubMed DOI
53. Meyer,R., Fofanov,V., Panigrahi,A., Merchant,F., Zhang,N. and Pati,D.
    Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers
    Clin Cancer Res15, 2703-2710. PubMed  Europe PubMed DOI
54. Sun,Y., Kucej,M., Fan,H.Y., Yu,H., Sun,Q.Y. and Zou,H.
    Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner
    Cell137, 123-132. PubMed  Europe PubMed DOI
55. Yang,X., Boateng,K.A., Strittmatter,L., Burgess,R. and Makaroff,C.A.
    Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis
    Plant Physiol151, 323-333. PubMed  Europe PubMed DOI
2008
56. Boos,D., Kuffer,C., Lenobel,R., Korner,R. and Stemmann,O.
    Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase
    J Biol Chem283, 816-823. PubMed  Europe PubMed DOI
57. Fujita,T., Epperly,M.W., Zou,H., Greenberger,J.S. and Wan,Y.
    Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells
    Mol Biol Cell19, 5446-5455. PubMed  Europe PubMed DOI
58. Huang,X., Andreu-Vieyra,C.V., York,J.P., Hatcher,R., Lu,T., Matzuk,M.M. and Zhang,P.
    Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells
    PLoS Biol6, e15-e15. PubMed  Europe PubMed DOI
59. Nabti,I., Reis,A., Levasseur,M., Stemmann,O. and Jones,K.T.
    Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs
    Dev Biol321, 379-386. PubMed  Europe PubMed DOI
60. Pati,D.
    Oncogenic activity of separase
    Cell Cycle7, 3481-3482. PubMed  Europe PubMed
61. Sak,A., Fegers,I., Groneberg,M. and Stuschke,M.
    Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines
    Cell Prolif41, 660-670. PubMed  Europe PubMed DOI
2007
62. Diaz-Martinez,L.A., Gimenez-Abian,J.F. and Clarke,D.J.
    Cohesin is dispensable for centromere cohesion in human cells
    PLoS ONE2, e318-e318. PubMed  Europe PubMed DOI
63. Gerber,S.A., Kettenbach,A.N., Rush,J. and Gygi,S.P.
    The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126
    Methods Mol Biol359, 71-86. PubMed  Europe PubMed DOI
64. Pemberton,H.N., Franklyn,J.A., Boelaert,K., Chan,S.Y., Kim,D.S., Kim,C., Cheng,S.Y., Kilby,M.D. and McCabe,C.J.
    Separase, securin and Rad21 in neural cell growth
    J Cell Physiol213, 45-53. PubMed  Europe PubMed DOI
65. [YEAR:1-1-2007]Shepard,J.L., Amatruda,J.F., Finkelstein,D., Ziai,J., Finley,K.R., Stern,H.M., Chiang,K., Hersey,C., Barut,B., Freeman,J.L., Lee,C., Glickman,J.N., Kutok,J.L., Aster,J.C. and Zon,L.I.
    A mutation in separase causes genome instability and increased susceptibility to epithelial cancer
    Genes Dev21, 55-59. PubMed  Europe PubMed DOI  M
2006
66. [YEAR:10-2-2006]Fan,H.Y., Sun,Q.Y. and Zou,H.
    Regulation of separase in meiosis: separase is activated at the metaphase I-II transition in Xenopus oocytes during meiosis
    Cell Cycle5, 198-204. PubMed  Europe PubMed
67. [YEAR:13-8-2006]Gorr,I.H., Reis,A., Boos,D., Wuhr,M., Madgwick,S., Jones,K.T. and Stemmann,O.
    Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes
    Nat Cell Biol8, 1035-1037. PubMed  Europe PubMed DOI
68. [YEAR:14-7-2006]Kudo,N.R., Wassmann,K., Anger,M., Schuh,M., Wirth,K.G., Xu,H., Helmhart,W., Kudo,H., McKay,M., Maro,B., Ellenberg,J., de Boer,P. and Nasmyth,K.
    Resolution of chiasmata in oocytes requires separase-mediated proteolysis
    Cell126, 135-146. PubMed  Europe PubMed DOI  K
69. [YEAR:13-3-2006]Kumada,K., Yao,R., Kawaguchi,T., Karasawa,M., Hoshikawa,Y., Ichikawa,K., Sugitani,Y., Imoto,I., Inazawa,J., Sugawara,M., Yanagida,M. and Noda,T.
    The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase
    J Cell Biol172, 835-846. PubMed  Europe PubMed DOI  K
70. Sun,Y., Yu,H. and Zou,H.
    Nuclear exclusion of separase prevents cohesin cleavage in interphase cells
    Cell Cycle5, 2537-2542. PubMed  Europe PubMed
2005
71. [YEAR:7-11-2005]Gimenez-Abian,J.F., Diaz-Martinez,L.A., Waizenegger,I.C., Gimenez-Martin,G. and Clarke,D.J.
    Separase is required at multiple pre-anaphase cell cycle stages in human cells
    Cell Cycle4, 1576-1584. PubMed  Europe PubMed
72. McGuinness,B.E., Hirota,T., Kudo,N.R., Peters,J.M. and Nasmyth,K.
    Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells
    PLoS Biol3, e86-e86. PubMed  Europe PubMed DOI
73. Queralt,E. and Uhlmann,F.
    More than a separase
    Nat Cell Biol7, 930-932. PubMed  Europe PubMed DOI
2004
74. Jager,H., Herzig,B., Herzig,A., Sticht,H., Lehner,C.F. and Heidmann,S.
    Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR
    Cell Cycle3, 182-188. PubMed  Europe PubMed
75. Peters,J.M. and Nasmyth,K.
    Separase
    [ISSN:0-12-079610-4]2, 1333-1337.  V
76. Romero,F., Gil-Bernabe,A.M., Saez,C., Japon,M.A., Pintor-Toro,J.A. and Tortolero,M.
    Securin is a target of the UV response pathway in mammalian cells
    Mol Cell Biol24, 2720-2733. PubMed  Europe PubMed DOI
2003
77. [YEAR:15-4-2003]Chestukhin,A., Pfeffer,C., Milligan,S., DeCaprio,J.A. and Pellman,D.
    Processing, localization, and requirement of human separase for normal anaphase progression
    Proc Natl Acad Sci U S A100, 4574-4579. PubMed  Europe PubMed DOI
78. [YEAR:14-10-2003]Terret,M.E., Wassmann,K., Waizenegger,I., Maro,B., Peters,J.M. and Verlhac,M.H.
    The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity
    Curr Biol13, 1797-1802. PubMed  Europe PubMed DOI
2002
79. [YEAR:20-8-2002]Waizenegger,I., Gimenez-Abian,J.F., Wernic,D. and Peters,J.M.
    Regulation of human separase by securin binding and autocleavage
    Curr Biol12, 1368-1378. PubMed  Europe PubMed DOI
2001
80. [YEAR:17-8-2001]Hauf,S., Waizenegger,I.C. and Peters,J.M.
    Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
    Science293, 1320-1323. PubMed  Europe PubMed DOI
81. [YEAR:18-5-2001]Jallepalli,P.V., Waizenegger,I.C., Bunz,F., Langer,S., Speicher,M.R., Peters,J.M., Kinzler,K.W., Vogelstein,B. and Lengauer,C.
    Securin is required for chromosomal stability in human cells
    Cell105, 445-457. PubMed  Europe PubMed DOI
82. [YEAR:7-8-2001]Mei,J., Huang,X. and Zhang,P.
    Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts
    Curr Biol11, 1197-1201. PubMed  Europe PubMed DOI
83. Nasmyth,K.
    Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis
    Annu Rev Genet35, 673-745. PubMed  Europe PubMed DOI  V
2000
84. [YEAR:27-10-2000]Waizenegger,I.C., Hauf,S., Meinke,A. and Peters,J.M.
    Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
    Cell103, 399-410. PubMed  Europe PubMed