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Literature for peptidase C50.002: separase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

(Topics flags: A Assay, M Mutation, K Knockout, P Specificity, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Anger,M.
    Nuances in the control of separase activity between mitosis and meiosis
    PLoS Biol (2025) 23, e3003206-e3003206. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Bouchoux,C. and Uhlmann,F.
    Why is your separase such a big protease?
    Sci Adv (2025) 11, eaec7431-eaec7431. PubMed  Europe PubMed DOI
  3. El Jailani,S., Cladiere,D., Nikalayevich,E., Touati,S.A., Chesnokova,V., Melmed,S., Buffin,E. and Wassmann,K.
    Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II
    EMBO J (2025) PubMed  Europe PubMed DOI
  4. Yu,J., Schmidt,S., Botto,M., Lee,K., Ghent,C.M., Goodfried,J.M., Howe,A., O'Reilly,F.J., Morgan,D.O. and Boland,A.
    Substrate recognition by human separase
    Sci Adv (2025) 11, eady9807-eady9807. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2024
  5. Picotto,J., Cipressa,F., Busso,D., Cenci,G., Bertrand,P. and Pennarun,G.
    Lamin B1-dependent regulation of human separase in mitosis
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  6. Zhu,Q., Du,L., Wu,J., Li,J. and Lin,Z.
    Walrycin B, as a novel separase inhibitor, exerts potent anticancer efficacy in a mouse xenograft model
    Biochem Pharmacol (2024) 229, 116502-116502. PubMed  Europe PubMed DOI  I
    7. 2023
  7. Konecna,M., Abbasi Sani,S. and Anger,M.
    Separase and Roads to Disengage Sister Chromatids during Anaphase
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  8. Yu,J., Morgan,D.O. and Boland,A.
    The molecular mechanisms of human separase regulation
    Biochem Soc Trans (2023) 51, 1225-1233. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2022
  9. Boukaba,A., Wu,Q., Liu,J., Chen,C., Liang,J., Li,J. and Strunnikov,A.V.
    Mapping separase-mediated cleavage in situ
    NAR Genom Bioinform (2022) 4, lqac085-lqac085. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Chen,J., Gao,C., Luo,M., Zheng,C., Lin,X., Ning,Y., Ma,L., He,W., Xie,D., Liu,K., Hong,K. and Han,C.
    MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage
    EMBO Rep (2022) 23, e54298-e54298. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Nikalayevich,E. and Wassmann,K.
    Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor
    STAR Protoc (2022) 3, 101714-101714. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Nikalayevich,E., El Jailani,S., Dupre,A., Cladiere,D., Gryaznova,Y., Fosse,C., Buffin,E., Touati,S.A. and Wassmann,K.
    Aurora B/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes
    Curr Biol (2022) 32, 2281-2290. PubMed  Europe PubMed DOI
  13. Shindo,N., Kumada,K., Iemura,K., Yasuda,J., Fujimori,H., Mochizuki,M., Tamai,K., Tanaka,K. and Hirota,T.
    Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1
    Cell Rep (2022) 41, 111723-111723. PubMed  Europe PubMed DOI
  14. Vijayakumari,D., Muller,J. and Hauf,S.
    Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase
    Cell Rep (2022) 38, 110554-110554. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Wassmann,K.
    Separase Control and Cohesin Cleavage in Oocytes: Should I Stay or Should I Go?
    Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
  16. Zhou,C.J., Wang,X.Y., Dong,Y.H., Wang,D.H., Han,Z., Zhang,X.J., Sun,Q.Y., Carroll,J. and Liang,C.G.
    CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I
    Nat Commun (2022) 13, 7732-7732. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2021
  17. Aouadi,E., Fornier,M., Gosseye,A., Castillo-Ferrer,C. and Frachet,V.
    [Separase, a key-player of mitosis: A new target for cancer therapy?]
    Med Sci (Paris) (2021) 37, 684-686. PubMed  Europe PubMed DOI
  18. Li,J., Zhang,H.Y., Wang,F., Sun,Q.Y. and Qian,W.P.
    The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II
    Front Cell Dev Biol (2021) 9, 648053-648053. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Maier,N.K., Ma,J., Lampson,M.A. and Cheeseman,I.M.
    Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition
    Dev Cell (2021) 56, 2192-2206. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Raia,P., Yu,J. and Boland,A.
    Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1
    Mol Cell Oncol (2021) 8, 1975473-1975473. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2020
  21. Hellmuth,S. and Stemmann,O.
    Separase-triggered apoptosis enforces minimal length of mitosis
    Nature (2020) 580, 542-547. PubMed  Europe PubMed DOI
  22. Hellmuth,S., Gomez-H,L., Pendas,A.M. and Stemmann,O.
    Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2
    Nature (2020) 580, 536-541. PubMed  Europe PubMed DOI  I
  23. Spiess,B., Kleiner,H., Flach,J., Fabarius,A., Saussele,S., Hofmann,W.K. and Seifarth,W.
    Separase activity distribution can be a marker of major molecular response and proliferation of CD34(+) cells in TKI-treated chronic myeloid leukemia patients
    Ann Hematol (2020) 99, 991-1006. PubMed  Europe PubMed DOI
    24. 2019
  24. Henschke,L., Frese,M., Hellmuth,S., Marx,A., Stemmann,O. and Mayer,T.U.
    Identification of bioactive small molecule inhibitors of separase
    ACS Chem Biol (2019) 14, 2155-2159. PubMed  Europe PubMed DOI  A  I
  25. Rosen,L.E., Klebba,J.E., Asfaha,J.B., Ghent,C.M., Campbell,M.G., Cheng,Y. and Morgan,D.O.
    Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
    Nat Commun (2019) 10, 5189-5189. PubMed  Europe PubMed DOI  PMC  EPMC  P
    26. 2018
  26. Cucco,F., Palumbo,E., Camerini,S., D'Alessio,B., Quarantotti,V., Casella,M.L., Rizzo,I.M., Cukrov,D., Delia,D., Russo,A., Crescenzi,M. and Musio,A.
    Separase prevents genomic instability by controlling replication fork speed
    Nucleic Acids Res (2018) 46, 267-278. PubMed  Europe PubMed DOI
  27. Hellmuth,S., Gutierrez-Caballero,C., Llano,E., Pendas,A.M. and Stemmann,O.
    Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation
    EMBO J (2018) 37, e99184-e99184. PubMed  Europe PubMed DOI
  28. Luo,S. and Tong,L.
    Structural biology of the separase-securin complex with crucial roles in chromosome segregation
    Curr Opin Struct Biol (2018) 49, 114-122. PubMed  Europe PubMed DOI  V
  29. Nikalayevich,E., Bouftas,N. and Wassmann,K.
    Detection of separase activity using a cleavage sensor in live mouse oocytes
    Methods Mol Biol (2018) 1818, 99-112. PubMed  Europe PubMed DOI  L
  30. Revinski,D.R., Zaragosi,L.E., Boutin,C., Ruiz-Garcia,S., Deprez,M., Thome,V., Rosnet,O., Gay,A.S., Mercey,O., Paquet,A., Pons,N., Ponzio,G., Marcet,B., Kodjabachian,L. and Barbry,P.
    CDC20B is required for deuterosome-mediated centriole production in multiciliated cells
    Nat Commun (2018) 9, 4668-4668. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Ruppenthal,S., Kleiner,H., Nolte,F., Fabarius,A., Hofmann,W.K., Nowak,D. and Seifarth,W.
    Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS
    PLoS ONE (2018) 13, e0191734-e0191734. PubMed  Europe PubMed DOI
    32. 2017
  32. Kumar,R.
    Separase: function beyond cohesion cleavage and an emerging oncogene
    J Cell Biochem (2017) 118, 1283-1299. PubMed  Europe PubMed DOI  V
  33. Zhang,N. and Pati,D.
    Biology and insights into the role of cohesin protease separase in human malignancies
    Biol Rev Camb Philos Soc (2017) 92, 2070-2083. PubMed  Europe PubMed DOI
    34. 2016
  34. Agircan,F.G., Hata,S., Nussbaum-Krammer,C., Atorino,E. and Schiebel,E.
    Proximity mapping of human separase by the BioID approach
    Biochem Biophys Res Commun (2016) 478, 656-662. PubMed  Europe PubMed DOI
  35. Do,H.T., Zhang,N., Pati,D. and Gilbertson,S.R.
    Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase
    Bioorg Med Chem Lett (2016) 26, 4446-4450. PubMed  Europe PubMed DOI  I
    36. 2015
  36. Haass,W., Kleiner,H., Weiss,C., Haferlach,C., Schlegelberger,B., Muller,M.C., Hehlmann,R., Hofmann,W.K., Fabarius,A. and Seifarth,W.
    Clonal evolution and blast crisis correlate with enhanced proteolytic activity of separase in BCR-ABL b3a2 fusion type CML under imatinib therapy
    PLoS ONE (2015) 10, e0129648-e0129648. PubMed  Europe PubMed DOI
  37. Haass,W., Kleiner,H., Muller,M.C., Hofmann,W.K., Fabarius,A. and Seifarth,W.
    Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay
    PLoS ONE (2015) 10, e0133769-e0133769. PubMed  Europe PubMed DOI  A  L
  38. Hellmuth,S., Pohlmann,C., Brown,A., Bottger,F., Sprinzl,M. and Stemmann,O.
    Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable
    J Biol Chem (2015) 290, 8002-8010. PubMed  Europe PubMed DOI
  39. Hellmuth,S., Rata,S., Brown,A., Heidmann,S., Novak,B. and Stemmann,O.
    Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1
    Mol Cell (2015) 58, 495-506. PubMed  Europe PubMed DOI
    40. 2014
  40. Agircan,F.G. and Schiebel,E.
    Sensors at centrosomes reveal determinants of local separase activity
    PLoS Genet (2014) 10, e1004672-e1004672. PubMed  Europe PubMed DOI  PMC  EPMC  L
  41. Hellmuth,S., Bottger,F., Pan,C., Mann,M. and Stemmann,O.
    PP2A delays APC/C-dependent degradation of separase-associated but not free securin
    EMBO J (2014) 33, 1134-1147. PubMed  Europe PubMed DOI
  42. Mukherjee,M., Ge,G., Zhang,N., Edwards,D.G., Sumazin,P., Sharan,S.K., Rao,P.H., Medina,D. and Pati,D.
    MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERalpha)-positive mammary adenocarcinomas
    Oncogene (2014) 33, 5511-5522. PubMed  Europe PubMed DOI
  43. Mukherjee,M., Byrd,T., Brawley,V.S., Bielamowicz,K., Li,X.N., Merchant,F., Maitra,S., Sumazin,P., Fuller,G., Kew,Y., Sun,D., Powell,S.Z., Ahmed,N.M., Zhang,N. and Pati,D.
    Overexpression and constitutive nuclear localization of cohesin protease separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme
    J Neurooncol (2014) 119, 27-35. PubMed  Europe PubMed DOI
  44. Zhang,N., Scorsone,K., Ge,G., Kaffes,C.C., Dobrolecki,L.E., Mukherjee,M., Lewis,M.T., Berg,S., Stephan,C.C. and Pati,D.
    Identification and characterization of separase inhibitors (sepins) for cancer therapy
    J Biomol Screen (2014) 19, 878-889. PubMed  Europe PubMed DOI  I
    45. 2013
  45. Han,X. and Poon,R.Y.
    Critical differences between isoforms of securin reveal mechanisms of separase regulation
    Mol Cell Biol (2013) 33, 3400-3415. PubMed  Europe PubMed DOI
    46. 2012
  46. Haass,W., Stehle,M., Nittka,S., Giehl,M., Schrotz-King,P., Fabarius,A., Hofmann,W.K. and Seifarth,W.
    The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib
    PLoS ONE (2012) 7, e42863-e42863. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Peters,J.M. and Nasmyth,K.
    Separase
    [ISSN:978-0-12-407743-0] (2012) 3, 2344-2350. DOI
    48. 2011
  48. Bacac,M., Fusco,C., Planche,A., Santodomingo,J., Demaurex,N., Leemann-Zakaryan,R., Provero,P. and Stamenkovic,I.
    Securin and separase modulate membrane traffic by affecting endosomal acidification
    Traffic (2011) 12, 615-626. PubMed  Europe PubMed DOI
  49. Chiang,T., Schultz,R.M. and Lampson,M.A.
    Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes
    Biol Reprod (2011) 85, 1279-1283. PubMed  Europe PubMed DOI
  50. Mukherjee,M., Ge,G., Zhang,N., Huang,E., Nakamura,L.V., Minor,M., Fofanov,V., Rao,P.H., Herron,A. and Pati,D.
    Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice
    PLoS ONE (2011) 6, e22167-e22167. PubMed  Europe PubMed DOI  PMC  EPMC  K
  51. Xu,J., Wang,M., Gao,X., Hu,B., Du,Y., Zhou,J., Tian,X. and Huang,X.
    Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis
    PLoS ONE (2011) 6, e18763-e18763. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Yang,X., Boateng,K.A., Yuan,L., Wu,S., Baskin,T.I. and Makaroff,C.A.
    The Radially Swollen 4 separase mutation of Arabidopsis thaliana blocks chromosome disjunction and disrupts the radial microtubule system in meiocytes
    PLoS ONE (2011) 6, e19459-e19459. PubMed  Europe PubMed DOI  PMC  EPMC  M
    53. 2010
  53. Wardlaw,C.P.
    Protein phosphatase 2A contributes to separase regulation and the co-ordination of anaphase
    Biosci Horiz (2010) 3, 66-76. DOI
    54. 2009
  54. Basu,D., Zhang,N., Panigrahi,A.K., Horton,T.M. and Pati,D.
    Development and validation of a fluorogenic assay to measure separase enzyme activity
    Anal Biochem (2009) 392, 133-138. PubMed  Europe PubMed DOI  PMC  EPMC  A
  55. Huang,X., Andreu-Vieyra,C.V., Wang,M., Cooney,A.J., Matzuk,M.M. and Zhang,P.
    Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation
    Mol Cell Biol (2009) 29, 1498-1505. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Kudo,N.R., Anger,M., Peters,A.H., Stemmann,O., Theussl,H.C., Helmhart,W., Kudo,H., Heyting,C. and Nasmyth,K.
    Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I
    J Cell Sci (2009) 122, 2686-2698. PubMed  Europe PubMed DOI
  57. Meyer,R., Fofanov,V., Panigrahi,A., Merchant,F., Zhang,N. and Pati,D.
    Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers
    Clin Cancer Res (2009) 15, 2703-2710. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Sun,Y., Kucej,M., Fan,H.Y., Yu,H., Sun,Q.Y. and Zou,H.
    Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner
    Cell (2009) 137, 123-132. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Yang,X., Boateng,K.A., Strittmatter,L., Burgess,R. and Makaroff,C.A.
    Arabidopsis separase functions beyond the removal of sister chromatid cohesion during meiosis
    Plant Physiol (2009) 151, 323-333. PubMed  Europe PubMed DOI  PMC  EPMC
    60. 2008
  60. Boos,D., Kuffer,C., Lenobel,R., Korner,R. and Stemmann,O.
    Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase
    J Biol Chem (2008) 283, 816-823. PubMed  Europe PubMed DOI
  61. Fujita,T., Epperly,M.W., Zou,H., Greenberger,J.S. and Wan,Y.
    Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells
    Mol Biol Cell (2008) 19, 5446-5455. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Huang,X., Andreu-Vieyra,C.V., York,J.P., Hatcher,R., Lu,T., Matzuk,M.M. and Zhang,P.
    Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells
    PLoS Biol (2008) 6, e15-e15. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Nabti,I., Reis,A., Levasseur,M., Stemmann,O. and Jones,K.T.
    Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs
    Dev Biol (2008) 321, 379-386. PubMed  Europe PubMed DOI
  64. Pati,D.
    Oncogenic activity of separase
    Cell Cycle (2008) 7, 3481-3482. PubMed  Europe PubMed  PMC  EPMC
  65. Sak,A., Fegers,I., Groneberg,M. and Stuschke,M.
    Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines
    Cell Prolif (2008) 41, 660-670. PubMed  Europe PubMed DOI
    66. 2007
  66. Diaz-Martinez,L.A., Gimenez-Abian,J.F. and Clarke,D.J.
    Cohesin is dispensable for centromere cohesion in human cells
    PLoS ONE (2007) 2, e318-e318. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Gerber,S.A., Kettenbach,A.N., Rush,J. and Gygi,S.P.
    The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126
    Methods Mol Biol (2007) 359, 71-86. PubMed  Europe PubMed DOI
  68. Pemberton,H.N., Franklyn,J.A., Boelaert,K., Chan,S.Y., Kim,D.S., Kim,C., Cheng,S.Y., Kilby,M.D. and McCabe,C.J.
    Separase, securin and Rad21 in neural cell growth
    J Cell Physiol (2007) 213, 45-53. PubMed  Europe PubMed DOI
  69. [YEAR:1-1-2007]Shepard,J.L., Amatruda,J.F., Finkelstein,D., Ziai,J., Finley,K.R., Stern,H.M., Chiang,K., Hersey,C., Barut,B., Freeman,J.L., Lee,C., Glickman,J.N., Kutok,J.L., Aster,J.C. and Zon,L.I.
    A mutation in separase causes genome instability and increased susceptibility to epithelial cancer
    Genes Dev (1-1-2007) 21, 55-59. PubMed  Europe PubMed DOI  PMC  EPMC  M
    70. 2006
  70. [YEAR:10-2-2006]Fan,H.Y., Sun,Q.Y. and Zou,H.
    Regulation of separase in meiosis: separase is activated at the metaphase I-II transition in Xenopus oocytes during meiosis
    Cell Cycle (10-2-2006) 5, 198-204. PubMed  Europe PubMed
  71. [YEAR:13-8-2006]Gorr,I.H., Reis,A., Boos,D., Wuhr,M., Madgwick,S., Jones,K.T. and Stemmann,O.
    Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes
    Nat Cell Biol (13-8-2006) 8, 1035-1037. PubMed  Europe PubMed DOI
  72. [YEAR:14-7-2006]Kudo,N.R., Wassmann,K., Anger,M., Schuh,M., Wirth,K.G., Xu,H., Helmhart,W., Kudo,H., McKay,M., Maro,B., Ellenberg,J., de Boer,P. and Nasmyth,K.
    Resolution of chiasmata in oocytes requires separase-mediated proteolysis
    Cell (14-7-2006) 126, 135-146. PubMed  Europe PubMed DOI  K
  73. [YEAR:13-3-2006]Kumada,K., Yao,R., Kawaguchi,T., Karasawa,M., Hoshikawa,Y., Ichikawa,K., Sugitani,Y., Imoto,I., Inazawa,J., Sugawara,M., Yanagida,M. and Noda,T.
    The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase
    J Cell Biol (13-3-2006) 172, 835-846. PubMed  Europe PubMed DOI  PMC  EPMC  K
  74. Sun,Y., Yu,H. and Zou,H.
    Nuclear exclusion of separase prevents cohesin cleavage in interphase cells
    Cell Cycle (2006) 5, 2537-2542. PubMed  Europe PubMed
    75. 2005
  75. [YEAR:7-11-2005]Gimenez-Abian,J.F., Diaz-Martinez,L.A., Waizenegger,I.C., Gimenez-Martin,G. and Clarke,D.J.
    Separase is required at multiple pre-anaphase cell cycle stages in human cells
    Cell Cycle (7-11-2005) 4, 1576-1584. PubMed  Europe PubMed
  76. McGuinness,B.E., Hirota,T., Kudo,N.R., Peters,J.M. and Nasmyth,K.
    Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells
    PLoS Biol (2005) 3, e86-e86. PubMed  Europe PubMed DOI  PMC  EPMC
  77. Queralt,E. and Uhlmann,F.
    More than a separase
    Nat Cell Biol (2005) 7, 930-932. PubMed  Europe PubMed DOI
    78. 2004
  78. Jager,H., Herzig,B., Herzig,A., Sticht,H., Lehner,C.F. and Heidmann,S.
    Structure predictions and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR
    Cell Cycle (2004) 3, 182-188. PubMed  Europe PubMed
  79. Peters,J.M. and Nasmyth,K.
    Separase
    [ISSN:0-12-079610-4] (2004) 2, 1333-1337.  V
  80. Romero,F., Gil-Bernabe,A.M., Saez,C., Japon,M.A., Pintor-Toro,J.A. and Tortolero,M.
    Securin is a target of the UV response pathway in mammalian cells
    Mol Cell Biol (2004) 24, 2720-2733. PubMed  Europe PubMed DOI  PMC  EPMC
    81. 2003
  81. [YEAR:15-4-2003]Chestukhin,A., Pfeffer,C., Milligan,S., DeCaprio,J.A. and Pellman,D.
    Processing, localization, and requirement of human separase for normal anaphase progression
    Proc Natl Acad Sci U S A (15-4-2003) 100, 4574-4579. PubMed  Europe PubMed DOI  PMC  EPMC
  82. [YEAR:14-10-2003]Terret,M.E., Wassmann,K., Waizenegger,I., Maro,B., Peters,J.M. and Verlhac,M.H.
    The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity
    Curr Biol (14-10-2003) 13, 1797-1802. PubMed  Europe PubMed DOI
    83. 2002
  83. [YEAR:20-8-2002]Waizenegger,I., Gimenez-Abian,J.F., Wernic,D. and Peters,J.M.
    Regulation of human separase by securin binding and autocleavage
    Curr Biol (20-8-2002) 12, 1368-1378. PubMed  Europe PubMed DOI
    84. 2001
  84. [YEAR:17-8-2001]Hauf,S., Waizenegger,I.C. and Peters,J.M.
    Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
    Science (17-8-2001) 293, 1320-1323. PubMed  Europe PubMed DOI
  85. [YEAR:18-5-2001]Jallepalli,P.V., Waizenegger,I.C., Bunz,F., Langer,S., Speicher,M.R., Peters,J.M., Kinzler,K.W., Vogelstein,B. and Lengauer,C.
    Securin is required for chromosomal stability in human cells
    Cell (18-5-2001) 105, 445-457. PubMed  Europe PubMed DOI
  86. [YEAR:7-8-2001]Mei,J., Huang,X. and Zhang,P.
    Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts
    Curr Biol (7-8-2001) 11, 1197-1201. PubMed  Europe PubMed DOI
  87. Nasmyth,K.
    Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis
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