Literature for peptidase C48.032: ChlaDub1 peptidase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zimmermann,T., Feng,J., Fischer,S., de Campos,L.J., Pinheiro,F.R., Sotriffer,C., Conda-Sheridan,M. and Decker,M.<br>Structural Optimization of Covalent Inhibitors for Deubiquitinase ChlaDUB1 of Chlamydia trachomatis as Antibiotic Agents<br>J Med Chem (2025) PubMed  Europe PubMed DOI
  2. 2024
  3. Bastidas,R.J., Kedzior,M., Davidson,R.K., Walsh,S.C., Dolat,L., Sixt,B.S., Pruneda,J.N., Coers,J. and Valdivia,R.H.<br>The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation<br>elife (2024) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Zimmermann,T., Feng,J., de Campos,L.J., Knight,L.A., Schlotzer,J., Ramirez,Y.A., Schwickert,K., Zehe,M., Adler,T.B., Schirmeister,T., Kisker,C., Sotriffer,C., Conda-Sheridan,M. and Decker,M.<br>Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis<br>J Med Chem (2024) 67, 10710-10742. PubMed  Europe PubMed DOI
  5. 2020
  6. Hausman,J.M., Kenny,S., Iyer,S., Babar,A., Qiu,J., Fu,J., Luo,Z.Q. and Das,C.<br>The two deubiquitinating enzymes from Chlamydia trachomatis have distinct ubiquitin recognition properties<br>Biochemistry (2020) 59, 1604-1617. PubMed  Europe PubMed DOI
  7. 2019
  8. Auer,D., Hugelschaffer,S.D., Fischer,A.B. and Rudel,T.<br>The chlamydial deubiquitinase Cdu1 supports recruitment of Golgi vesicles to the inclusion<br>Cell Microbiol (2019) , e13136-e13136. PubMed  Europe PubMed DOI
  9. 2018
  10. Pruneda,J.N., Bastidas,R.J., Bertsoulaki,E., Swatek,K.N., Santhanam,B., Clague,M.J., Valdivia,R.H., Urbe,S. and Komander,D.<br>A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation<br>Nat Microbiol (2018) 3, 1377-1384. PubMed  Europe PubMed DOI
  11. Ramirez,Y.A., Adler,T.B., Altmann,E., Klemm,T., Tiesmeyer,C., Sauer,F., Kathman,S.G., Statsyuk,A.V., Sotriffer,C. and Kisker,C.<br>Structural basis of substrate recognition and covalent inhibition of Cdu1 from Chlamydia trachomatis<br>ChemMedChem (2018) 13, 2014-2023. PubMed  Europe PubMed DOI  I
  12. 2016
  13. Pruneda,J.N., Durkin,C.H., Geurink,P.P., Ovaa,H., Santhanam,B., Holden,D.W. and Komander,D.<br>The molecular basis for ubiquitin and ubiquitin-like specificities in bacterial effector proteases<br>Mol Cell (2016) 63, 261-276. PubMed  Europe PubMed DOI  V  S
  14. 2008
  15. Le Negrate,G., Krieg,A., Faustin,B., Loeffler,M., Godzik,A., Krajewski,S. and Reed,J.C.<br>ChlaDub1 of Chlamydia trachomatis suppresses NF-kappaB activation and inhibits IkappaBalpha ubiquitination and degradation<br>Cell Microbiol (2008) 10, 1879-1892. PubMed  Europe PubMed DOI
  16. 2006
  17. Misaghi,S., Balsara,Z.R., Catic,A., Spooner,E., Ploegh,H.L. and Starnbach,M.N.<br>Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection<br>Mol Microbiol (2006) 61, 142-150. PubMed  Europe PubMed DOI