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Literature for peptidase C48.003: SENP3 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Wu,Y., Liu,Y., Shan,L., Li,X., Wu,B. and Guo,L.<br>HIF1alpha/PRDX1 axis drives pulmonary vascular remodeling through DRP1 DeSUMOylation and mitochondrial fragmentation<br>Biochim Biophys Acta Mol Basis Dis (2026) 1872, 168094-168094. PubMed  Europe PubMed DOI  K
    2. 2025
  2. Gordon,J., Kaminski,A.M., Bommu,S.R., Skrajna,A., Petrovich,R.M., Pedersen,L.C., McGinty,R.K., Warren,A.J. and Stanley,R.E.<br>PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex<br>Sci Adv (2025) 11, eadw4603-eadw4603. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Chen,J., Sun,X., Liu,Y., Zhang,Y., Zhao,M. and Shao,L.<br>SENP3 attenuates foam cell formation by deSUMOylating NLRP3 in macrophages stimulated with ox-LDL<br>Cell Signal (2024) 117, 111092-111092. PubMed  Europe PubMed DOI  K
  4. Chen,X., Wang,J., Yang,P., Liu,H.Y., Zhong,S., Lu,C., Gao,M., Liu,D., Zhang,J., Wang,J., Ma,S., Wang,W., Zhu,H., Zhang,X. and Liu,Y.<br>SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1<br>Redox Biol (2024) 75, 103267-103267. PubMed  Europe PubMed DOI
  5. Chen,X., Li,D., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Ding,S., Xu,R., Liu,Z., Long,X., Zhang,J., Yang,Z., Qi,Y. and Wu,H.<br>SENP3 mediates the deSUMOylation and degradation of YAP1 to regulate the progression of triple-negative breast cancer<br>J Biol Chem (2024) , 107764-107764. PubMed  Europe PubMed DOI
  6. Shah,R.B., Li,Y., Yu,H., Kini,E. and Sidi,S.<br>Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure<br>Nat Commun (2024) 15, 9195-9195. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Shao,Z., Liu,S., Sun,W., Zhuang,X., Yin,S., Cheng,J., Xia,X., Liao,Y., Liu,J. and Huang,H.<br>SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration<br>Cell Mol Biol Lett (2024) 29, 146-146. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Zhao,S., Xu,Z., Niu,X., Cao,C., Gu,Y., Wang,H., Lu,Q., Wu,Z., Li,L., Du,J. and Liao,M.<br>The role of SUMO specific peptidase 3 in secondary inflammation of ischemic stroke in mice<br>Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167104-167104. PubMed  Europe PubMed DOI
    9. 2023
  9. Donig,J., Mende,H., Davila Gallesio,J., Wagner,K., Hotz,P., Schunck,K., Piller,T., Holper,S., Uhan,S., Kaulich,M., Wirth,M., Keller,U., Tascher,G., Bohnsack,K.E. and Muller,S.<br>Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis<br>Nat Commun (2023) 14, 8121-8121. PubMed  Europe PubMed DOI  PMC  EPMC
  10. He,S., Fan,C., Ji,Y., Su,Q., Zhao,F., Xie,C., Chen,X., Zhang,Y. and Chen,Y.<br>SENP3 facilitates M1 macrophage polarization via the HIF-1alpha/PKM2 axis in lipopolysaccharide-induced acute lung injury<br>Innate Immun (2023) 29, 25-34. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Zhou,H., Feng,W., Yu,J., Shafiq,T.A., Paulo,J.A., Zhang,J., Luo,Z., Gygi,S.P. and Moazed,D.<br>SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions<br>Cell Rep (2023) 42, 112339-112339. PubMed  Europe PubMed DOI
    12. 2022
  12. Han,Y., Huang,X., Cao,X., Li,Y., Gao,L., Jia,J., Li,G., Guo,H., Liu,X., Zhao,H., Guan,H., Zhou,P. and Gao,S.<br>SENP3-mediated TIP60 deSUMOylation is required for DNA-PKcs activity and DNA damage repair<br>MedComm (2020) (2022) 3, e123-e123. PubMed  Europe PubMed DOI  PMC  EPMC  K
  13. Li,Z., Liu,J., Fu,H., Li,Y., Liu,Q., Song,W. and Zeng,M.<br>SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3<br>Aging (Albany NY) (2022) 14, 8032-8045. PubMed  Europe PubMed DOI  PMC  EPMC  K
  14. Nishida,T.<br>SUMO-specific protease SENP3 enhances MDM2-mediated ubiquitination of PARIS/ZNF746 in HeLa cells<br>Biochem Biophys Res Commun (2022) 615, 150-156. PubMed  Europe PubMed DOI  K
  15. Waters,E., Wilkinson,K.A., Harding,A.L., Carmichael,R.E., Robinson,D., Colley,H.E. and Guo,C.<br>The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1<br>EMBO Rep (2022) 23, e48754-e48754. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Xiao,M., Bian,Q., Lao,Y., Yi,J., Sun,X., Sun,X. and Yang,J.<br>SENP3 loss promotes M2 macrophage polarization and breast cancer progression<br>Mol Oncol (2022) 16, 1026-1044. PubMed  Europe PubMed DOI
    17. 2021
  17. Cai,Z., Wang,Z., Yuan,R., Cui,M., Lao,Y., Wang,Y., Nie,P., Shen,L., Yi,J. and He,B.<br>Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of beta-catenin and regulation of its stability<br>EBioMedicine (2021) 67, 103386-103386. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Chen,F., Yan,H., Guo,C., Zhu,H., Yi,J., Sun,X. and Yang,J.<br>Assessment of SENP3-interacting proteins in hepatocytes treated with diethylnitrosamine by BioID assay<br>Acta Biochim Biophys Sin (Shanghai) (2021) PubMed  Europe PubMed DOI
  19. Guo,C., Hildick,K.L., Jiang,J., Zhao,A., Guo,W., Henley,J.M. and Wilkinson,K.A.<br>SENP3 Promotes an Mff-Primed Bcl-x L -Drp1 Interaction Involved in Cell Death Following Ischemia<br>Front Cell Dev Biol (2021) 9, 752260-752260. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Hu,Z., Teng,X.L., Zhang,T., Yu,X., Ding,R., Yi,J., Deng,L., Wang,Z. and Zou,Q.<br>SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function<br>Mol Cell (2021) PubMed  Europe PubMed DOI
  21. Yu,B., Lin,Q., Huang,C., Zhang,B., Wang,Y., Jiang,Q., Zhang,C. and Yi,J.<br>SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A<br>J Cell Sci (2021) 134 PubMed  Europe PubMed DOI
    22. 2020
  22. Long,X., Zhao,B., Lu,W., Chen,X., Yang,X., Huang,J., Zhang,Y., An,S., Qin,Y., Xing,Z., Shen,Y., Wu,H. and Qi,Y.<br>The Critical Roles of the SUMO-Specific Protease SENP3 in Human Diseases and Clinical Implications<br>Front Physiol (2020) 11, 558220-558220. PubMed  Europe PubMed DOI  PMC  EPMC  V
    23. 2019
  23. Rawlings,N., Lee,L., Nakamura,Y., Wilkinson,K.A. and Henley,J.M.<br>Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury<br>PLoS ONE (2019) 14, e0213331-e0213331. PubMed  Europe PubMed DOI
    24. 2018
  24. Gao,L., Zhao,Y., He,J., Yan,Y., Xu,L., Lin,N., Ji,Q., Tong,R., Fu,Y., Gao,Y., Su,Y., Yuan,A., He,B. and Pu,J.<br>The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury<br>J Genet Genomics (2018) 45, 125-135. PubMed  Europe PubMed DOI  K
  25. Lao,Y., Yang,K., Wang,Z., Sun,X., Zou,Q., Yu,X., Cheng,J., Tong,X., Yeh,E.T.H., Yang,J. and Yi,J.<br>DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages<br>J Biol Chem (2018) 293, 3965-3980. PubMed  Europe PubMed DOI
  26. Yu,X., Lao,Y., Teng,X.L., Li,S., Zhou,Y., Wang,F., Guo,X., Deng,S., Chang,Y., Wu,X., Liu,Z., Chen,L., Lu,L.M., Cheng,J., Li,B., Su,B., Jiang,J., Li,H.B., Huang,C., Yi,J. and Zou,Q.<br>SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation<br>Nat Commun (2018) 9, 3157-3157. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2017
  27. Nayak,A., Reck,A., Morsczeck,C. and Muller,S.<br>Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes<br>Epigenetics Chromatin (2017) 10, 15-15. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Wang,D.P., Liu,K.J., Kasper,G., Lin,Q. and Hai,J.<br>Inhibition of SENP3 by URB597 ameliorates neurovascular unit dysfunction in rats with chronic cerebral hypoperfusion<br>Biomed Pharmacother (2017) 91, 872-879. PubMed  Europe PubMed DOI  I
    29. 2016
  29. Kunz,K., Wagner,K., Mendler,L., Holper,S., Dehne,N. and Muller,S.<br>SUMO signaling by hypoxic inactivation of SUMO-specific isopeptidases<br>Cell Rep (2016) 16, 3075-3086. PubMed  Europe PubMed DOI
  30. Mendes,A.V., Grou,C.P., Azevedo,J.E. and Pinto,M.P.<br>Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases<br>Biochim Biophys Acta (2016) 1863, 139-147. PubMed  Europe PubMed DOI
  31. Raman,N., Weir,E. and Muller,S.<br>The AAA ATPase MDN1 acts as a SUMO-targeted regulator in mammalian pre-ribosome remodeling<br>Mol Cell (2016) 64, 607-615. PubMed  Europe PubMed DOI
    32. 2015
  32. Huang,C.J., Wu,D., Khan,F.A. and Huo,L.J.<br>The SUMO protease SENP3 orchestrates G2-M transition and spindle assembly in mouse oocytes<br>Sci Rep (2015) 5, 15600-15600. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2014
  33. Nayak,A., Viale-Bouroncle,S., Morsczeck,C. and Muller,S.<br>The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation<br>Mol Cell (2014) 55, 47-58. PubMed  Europe PubMed DOI
  34. Ren,Y.H., Liu,K.J., Wang,M., Yu,Y.N., Yang,K., Chen,Q., Yu,B., Wang,W., Li,Q.W., Wang,J., Hou,Z.Y., Fang,J.Y., Yeh,E.T., Yang,J. and Yi,J.<br>De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells<br>Oncotarget (2014) 5, 7093-7104. PubMed  Europe PubMed
    35. 2013
  35. Guo,C., Hildick,K.L., Luo,J., Dearden,L., Wilkinson,K.A. and Henley,J.M.<br>SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia<br>EMBO J (2013) 32, 1514-1528. PubMed  Europe PubMed DOI
  36. Schuldt,A.<br>Post-translational modification: A SUMO protease for stress protection<br>Nat Rev Mol Cell Biol (2013) 14, 263-263. PubMed  Europe PubMed DOI
  37. Yang,W., Wang,L. and Paschen,W.<br>Development of a High-Throughput Screening Assay for Inhibitors of Small Ubiquitin-Like Modifier Proteases<br>J Biomol Screen (2013) 18, 621-628. PubMed  Europe PubMed DOI  A
    38. 2012
  38. Lu,L.S. and Yeh,E.T.H.<br>SENP3 and SENP5 peptidases<br>[ISSN:978-0-12-407743-0] (2012) 3, 2371-2375. DOI
    39. 2011
  39. Finkbeiner,E., Haindl,M. and Muller,S.<br>The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex<br>EMBO J (2011) 30, 1067-1078. PubMed  Europe PubMed DOI
  40. Nishida,T. and Yamada,Y.<br>The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation<br>Biochem Biophys Res Commun (2011) 406, 285-291. PubMed  Europe PubMed DOI
    41. 2010
  41. Han,Y., Huang,C., Sun,X., Xiang,B., Wang,M., Yeh,E.T., Chen,Y., Li,H., Shi,G., Cang,H., Sun,Y., Wang,J., Wang,W., Gao,F. and Yi,J.<br>SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress<br>J Biol Chem (2010) 285, 12906-12915. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Yan,S., Sun,X., Xiang,B., Cang,H., Kang,X., Chen,Y., Li,H., Shi,G., Yeh,E.T., Wang,B., Wang,X. and Yi,J.<br>Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90<br>EMBO J (2010) 29, 3773-3786. PubMed  Europe PubMed DOI
    43. 2009
  43. Huang,C., Han,Y., Wang,Y., Sun,X., Yan,S., Yeh,E.T., Chen,Y., Cang,H., Li,H., Shi,G., Cheng,J., Tang,X. and Yi,J.<br>SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation<br>EMBO J (2009) 28, 2748-2762. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Wang,Y., Mukhopadhyay,D., Mathew,S., Hasebe,T., Heimeier,R.A., Azuma,Y., Kolli,N., Shi,Y.B., Wilkinson,K.D. and Dasso,M.<br>Identification and developmental expression of Xenopus laevis SUMO proteases<br>PLoS ONE (2009) 4, e8462-e8462. PubMed  Europe PubMed DOI
    45. 2008
  45. Haindl,M., Harasim,T., Eick,D. and Muller,S.<br>The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing<br>EMBO Rep (2008) 9, 273-279. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Kuo,M.L., den Besten,W., Thomas,M.C. and Sherr,C.J.<br>Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3<br>Cell Cycle (2008) 7, 3378-3387. PubMed  Europe PubMed
  47. Nishida,T. and Yamada,Y.<br>SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin<br>Biochem Biophys Res Commun (2008) 374, 382-387. PubMed  Europe PubMed DOI
  48. Yun,C., Wang,Y., Mukhopadhyay,D., Backlund,P., Kolli,N., Yergey,A., Wilkinson,K.D. and Dasso,M.<br>Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases<br>J Cell Biol (2008) 183, 589-595. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 2000
  49. Nishida,T., Tanaka,H. and Yasuda,H.<br>A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase<br>Eur J Biochem (2000) 267, 6423-6427. PubMed  Europe PubMed DOI
  50. Yeh,E.T., Gong,L. and Kamitani,T.<br>Ubiquitin-like proteins: new wines in new bottles<br>Gene (2000) 248, 1-14. PubMed  Europe PubMed DOI

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