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Literature for peptidase C48.003: SENP3 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

(Topics flags: A Assay, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Wu,Y., Liu,Y., Shan,L., Li,X., Wu,B. and Guo,L.
    HIF1alpha/PRDX1 axis drives pulmonary vascular remodeling through DRP1 DeSUMOylation and mitochondrial fragmentation
    Biochim Biophys Acta Mol Basis Dis (2026) 1872, 168094-168094. PubMed  Europe PubMed DOI  K
    2. 2025
  2. Gordon,J., Kaminski,A.M., Bommu,S.R., Skrajna,A., Petrovich,R.M., Pedersen,L.C., McGinty,R.K., Warren,A.J. and Stanley,R.E.
    PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex
    Sci Adv (2025) 11, eadw4603-eadw4603. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Chen,J., Sun,X., Liu,Y., Zhang,Y., Zhao,M. and Shao,L.
    SENP3 attenuates foam cell formation by deSUMOylating NLRP3 in macrophages stimulated with ox-LDL
    Cell Signal (2024) 117, 111092-111092. PubMed  Europe PubMed DOI  K
  4. Chen,X., Wang,J., Yang,P., Liu,H.Y., Zhong,S., Lu,C., Gao,M., Liu,D., Zhang,J., Wang,J., Ma,S., Wang,W., Zhu,H., Zhang,X. and Liu,Y.
    SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1
    Redox Biol (2024) 75, 103267-103267. PubMed  Europe PubMed DOI
  5. Chen,X., Li,D., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Ding,S., Xu,R., Liu,Z., Long,X., Zhang,J., Yang,Z., Qi,Y. and Wu,H.
    SENP3 mediates the deSUMOylation and degradation of YAP1 to regulate the progression of triple-negative breast cancer
    J Biol Chem (2024) , 107764-107764. PubMed  Europe PubMed DOI
  6. Shah,R.B., Li,Y., Yu,H., Kini,E. and Sidi,S.
    Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure
    Nat Commun (2024) 15, 9195-9195. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Shao,Z., Liu,S., Sun,W., Zhuang,X., Yin,S., Cheng,J., Xia,X., Liao,Y., Liu,J. and Huang,H.
    SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration
    Cell Mol Biol Lett (2024) 29, 146-146. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Zhao,S., Xu,Z., Niu,X., Cao,C., Gu,Y., Wang,H., Lu,Q., Wu,Z., Li,L., Du,J. and Liao,M.
    The role of SUMO specific peptidase 3 in secondary inflammation of ischemic stroke in mice
    Biochim Biophys Acta Mol Basis Dis (2024) 1870, 167104-167104. PubMed  Europe PubMed DOI
    9. 2023
  9. Donig,J., Mende,H., Davila Gallesio,J., Wagner,K., Hotz,P., Schunck,K., Piller,T., Holper,S., Uhan,S., Kaulich,M., Wirth,M., Keller,U., Tascher,G., Bohnsack,K.E. and Muller,S.
    Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis
    Nat Commun (2023) 14, 8121-8121. PubMed  Europe PubMed DOI  PMC  EPMC
  10. He,S., Fan,C., Ji,Y., Su,Q., Zhao,F., Xie,C., Chen,X., Zhang,Y. and Chen,Y.
    SENP3 facilitates M1 macrophage polarization via the HIF-1alpha/PKM2 axis in lipopolysaccharide-induced acute lung injury
    Innate Immun (2023) 29, 25-34. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Zhou,H., Feng,W., Yu,J., Shafiq,T.A., Paulo,J.A., Zhang,J., Luo,Z., Gygi,S.P. and Moazed,D.
    SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions
    Cell Rep (2023) 42, 112339-112339. PubMed  Europe PubMed DOI
    12. 2022
  12. Han,Y., Huang,X., Cao,X., Li,Y., Gao,L., Jia,J., Li,G., Guo,H., Liu,X., Zhao,H., Guan,H., Zhou,P. and Gao,S.
    SENP3-mediated TIP60 deSUMOylation is required for DNA-PKcs activity and DNA damage repair
    MedComm (2020) (2022) 3, e123-e123. PubMed  Europe PubMed DOI  PMC  EPMC  K
  13. Li,Z., Liu,J., Fu,H., Li,Y., Liu,Q., Song,W. and Zeng,M.
    SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3
    Aging (Albany NY) (2022) 14, 8032-8045. PubMed  Europe PubMed DOI  PMC  EPMC  K
  14. Nishida,T.
    SUMO-specific protease SENP3 enhances MDM2-mediated ubiquitination of PARIS/ZNF746 in HeLa cells
    Biochem Biophys Res Commun (2022) 615, 150-156. PubMed  Europe PubMed DOI  K
  15. Waters,E., Wilkinson,K.A., Harding,A.L., Carmichael,R.E., Robinson,D., Colley,H.E. and Guo,C.
    The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1
    EMBO Rep (2022) 23, e48754-e48754. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Xiao,M., Bian,Q., Lao,Y., Yi,J., Sun,X., Sun,X. and Yang,J.
    SENP3 loss promotes M2 macrophage polarization and breast cancer progression
    Mol Oncol (2022) 16, 1026-1044. PubMed  Europe PubMed DOI
    17. 2021
  17. Cai,Z., Wang,Z., Yuan,R., Cui,M., Lao,Y., Wang,Y., Nie,P., Shen,L., Yi,J. and He,B.
    Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of beta-catenin and regulation of its stability
    EBioMedicine (2021) 67, 103386-103386. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Chen,F., Yan,H., Guo,C., Zhu,H., Yi,J., Sun,X. and Yang,J.
    Assessment of SENP3-interacting proteins in hepatocytes treated with diethylnitrosamine by BioID assay
    Acta Biochim Biophys Sin (Shanghai) (2021) PubMed  Europe PubMed DOI
  19. Guo,C., Hildick,K.L., Jiang,J., Zhao,A., Guo,W., Henley,J.M. and Wilkinson,K.A.
    SENP3 Promotes an Mff-Primed Bcl-x L -Drp1 Interaction Involved in Cell Death Following Ischemia
    Front Cell Dev Biol (2021) 9, 752260-752260. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Hu,Z., Teng,X.L., Zhang,T., Yu,X., Ding,R., Yi,J., Deng,L., Wang,Z. and Zou,Q.
    SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function
    Mol Cell (2021) PubMed  Europe PubMed DOI
  21. Yu,B., Lin,Q., Huang,C., Zhang,B., Wang,Y., Jiang,Q., Zhang,C. and Yi,J.
    SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A
    J Cell Sci (2021) 134 PubMed  Europe PubMed DOI
    22. 2020
  22. Long,X., Zhao,B., Lu,W., Chen,X., Yang,X., Huang,J., Zhang,Y., An,S., Qin,Y., Xing,Z., Shen,Y., Wu,H. and Qi,Y.
    The Critical Roles of the SUMO-Specific Protease SENP3 in Human Diseases and Clinical Implications
    Front Physiol (2020) 11, 558220-558220. PubMed  Europe PubMed DOI  PMC  EPMC  V
    23. 2019
  23. Rawlings,N., Lee,L., Nakamura,Y., Wilkinson,K.A. and Henley,J.M.
    Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury
    PLoS ONE (2019) 14, e0213331-e0213331. PubMed  Europe PubMed DOI
    24. 2018
  24. Gao,L., Zhao,Y., He,J., Yan,Y., Xu,L., Lin,N., Ji,Q., Tong,R., Fu,Y., Gao,Y., Su,Y., Yuan,A., He,B. and Pu,J.
    The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury
    J Genet Genomics (2018) 45, 125-135. PubMed  Europe PubMed DOI  K
  25. Lao,Y., Yang,K., Wang,Z., Sun,X., Zou,Q., Yu,X., Cheng,J., Tong,X., Yeh,E.T.H., Yang,J. and Yi,J.
    DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages
    J Biol Chem (2018) 293, 3965-3980. PubMed  Europe PubMed DOI
  26. Yu,X., Lao,Y., Teng,X.L., Li,S., Zhou,Y., Wang,F., Guo,X., Deng,S., Chang,Y., Wu,X., Liu,Z., Chen,L., Lu,L.M., Cheng,J., Li,B., Su,B., Jiang,J., Li,H.B., Huang,C., Yi,J. and Zou,Q.
    SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
    Nat Commun (2018) 9, 3157-3157. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2017
  27. Nayak,A., Reck,A., Morsczeck,C. and Muller,S.
    Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes
    Epigenetics Chromatin (2017) 10, 15-15. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Wang,D.P., Liu,K.J., Kasper,G., Lin,Q. and Hai,J.
    Inhibition of SENP3 by URB597 ameliorates neurovascular unit dysfunction in rats with chronic cerebral hypoperfusion
    Biomed Pharmacother (2017) 91, 872-879. PubMed  Europe PubMed DOI  I
    29. 2016
  29. Kunz,K., Wagner,K., Mendler,L., Holper,S., Dehne,N. and Muller,S.
    SUMO signaling by hypoxic inactivation of SUMO-specific isopeptidases
    Cell Rep (2016) 16, 3075-3086. PubMed  Europe PubMed DOI
  30. Mendes,A.V., Grou,C.P., Azevedo,J.E. and Pinto,M.P.
    Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases
    Biochim Biophys Acta (2016) 1863, 139-147. PubMed  Europe PubMed DOI
  31. Raman,N., Weir,E. and Muller,S.
    The AAA ATPase MDN1 acts as a SUMO-targeted regulator in mammalian pre-ribosome remodeling
    Mol Cell (2016) 64, 607-615. PubMed  Europe PubMed DOI
    32. 2015
  32. Huang,C.J., Wu,D., Khan,F.A. and Huo,L.J.
    The SUMO protease SENP3 orchestrates G2-M transition and spindle assembly in mouse oocytes
    Sci Rep (2015) 5, 15600-15600. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2014
  33. Nayak,A., Viale-Bouroncle,S., Morsczeck,C. and Muller,S.
    The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation
    Mol Cell (2014) 55, 47-58. PubMed  Europe PubMed DOI
  34. Ren,Y.H., Liu,K.J., Wang,M., Yu,Y.N., Yang,K., Chen,Q., Yu,B., Wang,W., Li,Q.W., Wang,J., Hou,Z.Y., Fang,J.Y., Yeh,E.T., Yang,J. and Yi,J.
    De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells
    Oncotarget (2014) 5, 7093-7104. PubMed  Europe PubMed
    35. 2013
  35. Guo,C., Hildick,K.L., Luo,J., Dearden,L., Wilkinson,K.A. and Henley,J.M.
    SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia
    EMBO J (2013) 32, 1514-1528. PubMed  Europe PubMed DOI
  36. Schuldt,A.
    Post-translational modification: A SUMO protease for stress protection
    Nat Rev Mol Cell Biol (2013) 14, 263-263. PubMed  Europe PubMed DOI
  37. Yang,W., Wang,L. and Paschen,W.
    Development of a High-Throughput Screening Assay for Inhibitors of Small Ubiquitin-Like Modifier Proteases
    J Biomol Screen (2013) 18, 621-628. PubMed  Europe PubMed DOI  A
    38. 2012
  38. Lu,L.S. and Yeh,E.T.H.
    SENP3 and SENP5 peptidases
    [ISSN:978-0-12-407743-0] (2012) 3, 2371-2375. DOI
    39. 2011
  39. Finkbeiner,E., Haindl,M. and Muller,S.
    The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex
    EMBO J (2011) 30, 1067-1078. PubMed  Europe PubMed DOI
  40. Nishida,T. and Yamada,Y.
    The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation
    Biochem Biophys Res Commun (2011) 406, 285-291. PubMed  Europe PubMed DOI
    41. 2010
  41. Han,Y., Huang,C., Sun,X., Xiang,B., Wang,M., Yeh,E.T., Chen,Y., Li,H., Shi,G., Cang,H., Sun,Y., Wang,J., Wang,W., Gao,F. and Yi,J.
    SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress
    J Biol Chem (2010) 285, 12906-12915. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Yan,S., Sun,X., Xiang,B., Cang,H., Kang,X., Chen,Y., Li,H., Shi,G., Yeh,E.T., Wang,B., Wang,X. and Yi,J.
    Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90
    EMBO J (2010) 29, 3773-3786. PubMed  Europe PubMed DOI
    43. 2009
  43. Huang,C., Han,Y., Wang,Y., Sun,X., Yan,S., Yeh,E.T., Chen,Y., Cang,H., Li,H., Shi,G., Cheng,J., Tang,X. and Yi,J.
    SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
    EMBO J (2009) 28, 2748-2762. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Wang,Y., Mukhopadhyay,D., Mathew,S., Hasebe,T., Heimeier,R.A., Azuma,Y., Kolli,N., Shi,Y.B., Wilkinson,K.D. and Dasso,M.
    Identification and developmental expression of Xenopus laevis SUMO proteases
    PLoS ONE (2009) 4, e8462-e8462. PubMed  Europe PubMed DOI
    45. 2008
  45. Haindl,M., Harasim,T., Eick,D. and Muller,S.
    The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
    EMBO Rep (2008) 9, 273-279. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Kuo,M.L., den Besten,W., Thomas,M.C. and Sherr,C.J.
    Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3
    Cell Cycle (2008) 7, 3378-3387. PubMed  Europe PubMed
  47. Nishida,T. and Yamada,Y.
    SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin
    Biochem Biophys Res Commun (2008) 374, 382-387. PubMed  Europe PubMed DOI
  48. Yun,C., Wang,Y., Mukhopadhyay,D., Backlund,P., Kolli,N., Yergey,A., Wilkinson,K.D. and Dasso,M.
    Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases
    J Cell Biol (2008) 183, 589-595. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 2000
  49. Nishida,T., Tanaka,H. and Yasuda,H.
    A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase
    Eur J Biochem (2000) 267, 6423-6427. PubMed  Europe PubMed DOI
  50. Yeh,E.T., Gong,L. and Kamitani,T.
    Ubiquitin-like proteins: new wines in new bottles
    Gene (2000) 248, 1-14. PubMed  Europe PubMed DOI

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