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Literature for peptidase C48.002: SENP1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bragado,L., Pozzi,B., Beckerman,I., Magalnik,M. and Srebrow,A.
    SUMO conjugation to promoter-proximal sequence elements-associated proteins impacts on snRNA transcription
    Proc Natl Acad Sci U S A (2025) 122, e2417409122-e2417409122. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Feng,X., Wu,G. and Zeng,Q.
    SENP1: A perspective from immune cells to disease (Review)
    Oncol Rep (2025) 54 PubMed  Europe PubMed DOI  PMC  EPMC
  3. Jiang,K., Yang,W., Huang,J., Tan,X., Liu,Y., Tu,S. and Luo,J.
    SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance
    Int J Mol Med (2025) 56 PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Zou,J., Chen,J., Deng,L., Xu,B., Yu,T., Wang,J. and He,C.
    Mechanistic Insights into SENP1 and OCT4 Interaction in Promoting Drug Resistance and Stem Cell Features in Colon Cancer
    Am J Physiol Cell Physiol (2025) PubMed  Europe PubMed DOI  K
    5. 2024
  5. Hui,Y., Xia,K., Zhong,J., Zhang,Y., Qiu,Q., Chen,Z., Wang,L. and Liu,X.
    SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1alpha
    J Cell Mol Med (2024) 28, e70043-e70043. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Ikeda,Y., Yuki,R., Saito,Y. and Nakayama,Y.
    DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity
    FASEB J (2024) 38, e70261-e70261. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Kang,L., Wang,X., Wang,J., Guo,J., Zhang,W. and Lei,R.
    SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription
    Biochim Biophys Acta Gen Subj (2024) 1868, 130500-130500. PubMed  Europe PubMed DOI  K
  8. Lin,H., Suzuki,K., Smith,N., Li,X., Nalbach,L., Fuentes,S., Spigelman,A.F., Dai,X.Q., Bautista,A., Ferdaoussi,M., Aggarwal,S., Pepper,A.R., Roma,L.P., Ampofo,E., Li,W.H. and MacDonald,P.E.
    A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding
    Nat Commun (2024) 15, 334-334. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Qi,J., Yan,L., Sun,J., Huang,C., Su,B., Cheng,J. and Shen,L.
    SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5
    Proc Natl Acad Sci U S A (2024) 121, e2314619121-e2314619121. PubMed  Europe PubMed DOI
  10. Stevens,T.A., Tomaleri,G.P., Hazu,M., Wei,S., Nguyen,V.N., DeKalb,C., Voorhees,R.M. and Pleiner,T.
    A nanobody-based strategy for rapid and scalable purification of human protein complexes
    Nat Protoc (2024) 19, 127-158. PubMed  Europe PubMed DOI
  11. Xu,X., Mao,Y., Feng,Z., Dai,F., Gu,T. and Zheng,J.
    SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1
    Oncol Rep (2024) 51 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Zeng,W., Wang,L., Wang,C., Xiong,X., Huang,Q., Chen,S., Liu,C., Liu,W., Wang,Y. and Huang,Q.
    SENP1 prevents high fat diet-induced non-alcoholic fatty liver diseases by regulating mitochondrial dynamics
    Biochim Biophys Acta Mol Basis Dis (2024) 1871, 167527-167527. PubMed  Europe PubMed DOI
    13. 2023
  13. Dai,T., Zhang,L., Ran,Y., Zhang,M., Yang,B., Lu,H., Lin,S., Zhang,L. and Zhou,F.
    MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
    Nat Struct Mol Biol (2023) 30, 785-799. PubMed  Europe PubMed DOI
  14. Lemma,R.B., Ledsaak,M., Fuglerud,B.M., Rodriguez-Castaneda,F., Eskeland,R. and Gabrielsen,O.S.
    MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape
    J Biol Chem (2023) 299, 105062-105062. PubMed  Europe PubMed DOI  PMC  EPMC  K
  15. Liu,W., Wang,Y., Bozi,L.H.M., Fischer,P.D., Jedrychowski,M.P., Xiao,H., Wu,T., Darabedian,N., He,X., Mills,E.L., Burger,N., Shin,S., Reddy,A., Sprenger,H.G., Tran,N., Winther,S., Hinshaw,S.M., Shen,J., Seo,H.S., Song,K., Xu,A.Z., Sebastian,L., Zhao,J.J., Dhe-Paganon,S., Che,J., Gygi,S.P., Arthanari,H. and Chouchani,E.T.
    Lactate regulates cell cycle by remodelling the anaphase promoting complex
    Nature (2023) 616, 790-797. PubMed  Europe PubMed DOI
  16. Wei,M., Huang,X., Liao,L., Tian,Y. and Zheng,X.
    SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer
    Cancer Res (2023) 83, 2908-2923. PubMed  Europe PubMed DOI
  17. Xu,M., Wang,S., Zhan,Q. and Lin,Y.
    Conditional protein splicing triggered by SUMO protease
    Biochem Biophys Res Commun (2023) 655, 44-49. PubMed  Europe PubMed DOI
  18. Zhang,R., Liu,Q., Lyu,C., Gao,X. and Ma,W.
    Knockdown SENP1 Suppressed the Angiogenic Potential of Mesenchymal Stem Cells by Impacting CXCR4-Regulated MRTF-A SUMOylation and CCN1 Expression
    Biomedicines (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC  K
    19. 2022
  19. Bailly,C.
    Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora
    Bioorg Med Chem (2022) 70, 116935-116935. PubMed  Europe PubMed DOI  V  I
  20. Brand,M., Bommeli,E.B., Rutimann,M., Lindenmann,U. and Riedl,R.
    Discovery of a Dual SENP1 and SENP2 Inhibitor
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Wang,K., Xiong,J., Lu,Y., Wang,L. and Tian,T.
    SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization
    FEBS J (2022) PubMed  Europe PubMed DOI
  22. Wei,H., Guo,J., Sun,X., Gou,W., Ning,H., Shang,H., Liu,Q., Hou,W. and Li,Y.
    Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study
    J Nat Prod (2022) 85, 1248-1255. PubMed  Europe PubMed DOI  I
  23. Wei,J., Wang,H., Zheng,Q., Zhang,J., Chen,Z., Wang,J., Ouyang,L. and Wang,Y.
    Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers
    Eur J Med Chem (2022) 241, 114650-114650. PubMed  Europe PubMed DOI  V
  24. Yan,L., Zhang,T., Wang,K., Chen,Z., Yang,Y., Shan,B., Sun,Q., Zhang,M., Zhang,Y., Zhong,Y., Liu,N., Gu,J. and Xu,D.
    SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
    Nat Commun (2022) 13, 7153-7153. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2021
  25. Goossens,J.F., Goossens,L. and Bailly,C.
    Hinokiflavone and Related C-O-C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action
    Nat Prod Bioprospect (2021) PubMed  Europe PubMed DOI  PMC  EPMC  V  I
  26. Li,J., Wu,R., Yung,M.M.H., Sun,J., Li,Z., Yang,H., Zhang,Y., Liu,S.S., Cheung,A.N.Y., Ngan,H.Y.S., Braisted,J.C., Zheng,W., Wei,H., Gao,Y., Nemes,P., Pei,H., Chan,D.W., Li,Y. and Zhu,W.
    SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance
    Cell Death Dis (2021) 12, 341-341. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Li,Y.Y., Cen,H., Gong,B.N., Mai,S., Wang,Q.L., Mou,S. and Li,Y.
    TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity
    Front Cell Dev Biol (2021) 9, 789348-789348. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Liu,Y., Shen,Y., Song,Y., Xu,L., Perry,P. and Liao,J.
    Isopeptidase Kinetics Determination by a Real Time and Sensitive qFRET Approach
    Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  29. Qing,Z., Huang,H., Yang,S., Lin,J., Zeng,Z., Duan,J., Yuan,B. and Ming,T.
    Hypoxia maintains the fenestration of liver sinusoidal endothelial cells and promotes their proliferation through the SENP1/HIF-1alpha/VEGF signaling axis
    Biochem Biophys Res Commun (2021) 540, 42-50. PubMed  Europe PubMed DOI
  30. Shangguan,X., He,J., Ma,Z., Zhang,W., Ji,Y., Shen,K., Yue,Z., Li,W., Xin,Z., Zheng,Q., Cao,Y., Pan,J., Dong,B., Cheng,J., Wang,Q. and Xue,W.
    SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
    Nat Commun (2021) 12, 1812-1812. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Silveirinha,V.C., Lin,H., Tanifuji,S., Mochida,S., Cottrell,G.S., Cimarosti,H. and Stephens,G.J.
    CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways
    Cell Calcium (2021) 93, 102326-102326. PubMed  Europe PubMed DOI
  32. Wang,J.Q., Lin,Z.C., Li,L.L., Zhang,S.F., Li,W.H., Liu,W., Song,B.L. and Luo,J.
    SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1
    J Biol Chem (2021) 296, 100032-100032. PubMed  Europe PubMed DOI
    33. 2020
  33. Chauhan,K.M., Chen,Y., Chen,Y., Liu,A.T., Sun,X.X. and Dai,M.S.
    The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity
    J Cell Biochem (2020) PubMed  Europe PubMed DOI
  34. Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T. and Salmona,M.
    Neuronal Localization of SENP Proteins with Super Resolution Microscopy
    Brain Sci (2020) 10 PubMed  Europe PubMed DOI
  35. Islam,M.R., Choi,S., Muthamilselvan,T., Shin,K. and Hwang,I.
    In vivo removal of N-terminal fusion domains from recombinant target proteins produced in Nicotiana benthamiana
    Front Plant Sci (2020) 11, 440-440. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Lindenmann,U., Brand,M., Gall,F., Frasson,D., Hunziker,L., Kroslakova,I., Sievers,M. and Riedl,R.
    Discovery of a class of potent and selective non-competitive sentrin-specific protease 1 inhibitors
    ChemMedChem (2020) 15, 675-679. PubMed  Europe PubMed DOI  I
  37. Yu,Y., Chen,Y., Liu,K., Cheng,J. and Tu,J.
    SUMOylation enhances the activity of IDH2 under oxidative stress
    Biochem Biophys Res Commun (2020) 532, 591-597. PubMed  Europe PubMed DOI
    38. 2019
  38. Ambaye,N.D.
    Noncovalent structure of SENP1 in complex with SUMO2
    Acta Crystallogr F Struct Biol Commun (2019) 75, 332-339. PubMed  Europe PubMed DOI  S
  39. Huang,X., Zuo,Y., Wang,X., Wu,X., Tan,H., Fan,Q., Dong,B., Xue,W., Chen,G.Q. and Cheng,J.
    SUMO-Specific protease 1 is critical for myeloid-derived suppressor cell development and function
    Cancer Res (2019) 79, 3891-3902. PubMed  Europe PubMed DOI
  40. Lee,A., Zhu,Y., Sabo,Y. and Goff,S.P.
    Embryonic cells redistribute SUMO1 upon forced SUMO1 overexpression
    MBio (2019) 10 PubMed  Europe PubMed DOI
    41. 2018
  41. Ambaye,N., Chen,C.H., Khanna,S., Li,Y.J. and Chen,Y.
    Streptonigrin inhibits SENP1 and reduces the protein level of hypoxia-inducible factor 1alpha (HIF1alpha) in cells
    Biochemistry (2018) 57, 1807-1813. PubMed  Europe PubMed DOI  I
  42. Jiao,D., Wu,M., Ji,L., Liu,F. and Liu,Y.
    microRNA-186 suppresses cell proliferation and metastasis through targeting sentrin-specific protease 1 in renal cell carcinoma
    Oncol Res (2018) 26, 249-259. PubMed  Europe PubMed DOI  K
  43. Rodriguez-Castaneda,F., Lemma,R.B., Cuervo,I., Bengtsen,M., Moen,L.M., Ledsaak,M., Eskeland,R. and Gabrielsen,O.S.
    The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression
    J Biol Chem (2018) 293, 15439-15454. PubMed  Europe PubMed DOI
  44. Sun,X.X., Chen,Y., Su,Y., Wang,X., Chauhan,K.M., Liang,J., Daniel,C.J., Sears,R.C. and Dai,M.S.
    SUMO protease SENP1 deSUMOylates and stabilizes c-Myc
    Proc Natl Acad Sci U S A (2018) 115, 10983-10988. PubMed  Europe PubMed DOI
  45. Zhou,G.Q., Han,F., Shi,Z.L., Yu,L., Li,X.F., Yu,C., Shen,C.L., Wan,D.W., Zhu,X.G., Li,R. and He,S.B.
    MiR-133a-3p targets SUMO-specific protease 1 to inhibit cell proliferation and cell cycle progress in colorectal cancer
    Oncol Res (2018) 26, 795-800. PubMed  Europe PubMed DOI
    46. 2017
  46. Bawa-Khalfe,T., Yang,F.M., Ritho,J., Lin,H.K., Cheng,J. and Yeh,E.T.
    SENP1 regulates PTEN stability to dictate prostate cancer development
    Oncotarget (2017) 8, 17651-17664. PubMed  Europe PubMed DOI
    47. 2016
  47. Chen,Y.-Y., Sun,J.-L., Li,S., Zhang,J. and Wu,Y.-L.
    Preliminary study on the synthesis and biological activity of small molecule inhibitor JK043 of SUMO-specific protease 1
    J Shanghai Jiaotong Univ Med Sci (2016) 36, 224-228. DOI  I
  48. Dong,B., Gao,Y., Kang,X., Gao,H., Zhang,J., Guo,H., You,M.J., Xue,W., Cheng,J. and Huang,Y.
    SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis
    Oncotarget (2016) 7, 80435-80449. PubMed  Europe PubMed DOI
  49. Kunz,K., Wagner,K., Mendler,L., Holper,S., Dehne,N. and Muller,S.
    SUMO signaling by hypoxic inactivation of SUMO-specific isopeptidases
    Cell Rep (2016) 16, 3075-3086. PubMed  Europe PubMed DOI
  50. Mendes,A.V., Grou,C.P., Azevedo,J.E. and Pinto,M.P.
    Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases
    Biochim Biophys Acta (2016) 1863, 139-147. PubMed  Europe PubMed DOI
  51. Mirecka,A., Morawiec,Z. and Wozniak,K.
    Genetic polymorphism of SUMO-specific cysteine proteases - SENP1 and SENP2 in breast cancer
    Pathol Oncol Res (2016) 22, 817-823. PubMed  Europe PubMed DOI  M
  52. Wang,F.-F., Liu,M.-Z., Sui,Y., Cao,Q., Yan,B., Jin,M.-L. and Mo,X.
    Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia
    Oncol Lett (2016) 12, 3755-3762. PubMed  Europe PubMed DOI  K
  53. Wang,Z., Jin,J., Zhang,J., Wang,L. and Cao,J.
    Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells
    Oncol Rep (2016) 36, 2071-2078. PubMed  Europe PubMed DOI  K
  54. Wu,J., Lei,H., Zhang,J., Chen,X., Tang,C., Wang,W., Xu,H., Xiao,W., Gu,W. and Wu,Y.
    Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation
    Oncotarget (2016) 7, 58995-59005. PubMed  Europe PubMed DOI  I
  55. Xie,W., Wang,Z., Zhang,J., Wang,L., Zhao,Y. and Zhou,H.
    Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitors
    Bioorg Med Chem Lett (2016) 26, 2124-2128. PubMed  Europe PubMed DOI  A
  56. Yoshioka,Y., Namiki,D., Makiuchi,M., Sugaya,K., Onose,J., Ashida,H. and Abe,N.
    Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-alpha production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity
    Bioorg Med Chem Lett (2016) 26, 4237-4240. PubMed  Europe PubMed DOI  I
    57. 2015
  57. Li,Y.M., Xu,C.S., Li,Z.Y. and Chen,X.
    [Effects of SUMO specific protease 1 on hPXR-mediated P-gp gene expression]
    Yao Xue Xue Bao (2015) 50, 1192-1196. PubMed  Europe PubMed
  58. Xu,J., Sun,H.Y., Xiao,F.J., Wang,H., Yang,Y., Wang,L., Gao,C.J., Guo,Z.K., Wu,C.T. and Wang,L.S.
    SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-kappaB signaling
    Biochem Biophys Res Commun (2015) 460, 409-415. PubMed  Europe PubMed DOI  K
    59. 2014
  59. Chen,C.H., Namanja,A.T. and Chen,Y.
    Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding
    Nat Commun (2014) 5, 4968-4968. PubMed  Europe PubMed DOI
  60. Chow,K.-H., Elgort,S., Dasso,M., Powers,M.A. and Ullman,K.S.
    The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
    Mol Biol Cell (2014) 25, 160-168. PubMed  Europe PubMed DOI
  61. Gu,J., Fan,Y., Liu,X., Zhou,L., Cheng,J., Cai,R. and Xue,S.
    SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1alpha-dependent pathway
    Cardiovasc Res (2014) 104, 83-92. PubMed  Europe PubMed DOI
  62. Lee,W.P., Jena,S., Doherty,D., Ventakesh,J., Schimdt,J., Furmick,J., Widener,T., Lemau,J., Jurutka,P.W. and Thompson,P.D.
    Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling
    PLoS ONE (2014) 9, e89506-e89506. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Liu,B., Wang,T., Mei,W., Li,D., Cai,R., Zuo,Y. and Cheng,J.
    Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation
    J Biol Chem (2014) 289, 22358-22364. PubMed  Europe PubMed DOI
    64. 2013
  64. Jiang,L., Liu,Y., Song,Y., Saavedra,A.N., Pan,S., Xiang,W. and Liao,J.
    Internal calibration Forster resonance energy transfer assay: a real-time approach for determining protease kinetics
    Sensors (2013) 13, 4553-4570. PubMed  Europe PubMed DOI  A
  65. Li,S., Wang,M., Ao,X., Chang,A.K., Yang,C., Zhao,F., Bi,H., Liu,Y., Xiao,L. and Wu,H.
    CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha
    Oncogene (2013) 32, 4883-4891. PubMed  Europe PubMed DOI
  66. Liu,Y. and Liao,J.
    Quantitative FRET (Forster resonance energy transfer) analysis for SENP1 protease kinetics determination
    J Vis Exp (2013) , e4430-e4430. PubMed  Europe PubMed DOI  A
  67. Obata,S., Yuasa,E., Seki,D., Kitano,T. and Saitoh,H.
    Molecular cloning and bacterial expression of the catalytic domain of the SENP1 gene of Oryzias latipes
    Biosci Biotechnol Biochem (2013) 77, 1788-1791. PubMed  Europe PubMed DOI
  68. Shi,T., Han,Y., Li,W., Zhao,Y., Liu,Y., Huang,Z., Lu,S. and Zhang,J.
    Exploring the desumoylation process of SENP1: a study combined MD simulations with QM/MM calculations on SENP1-SUMO1-RanGAP1
    J Chem Inf Model (2013) 53, 2360-2368. PubMed  Europe PubMed DOI
  69. Sommer,S., Weikart,N.D., Linne,U. and Mootz,H.D.
    Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition
    Bioorg Med Chem (2013) 21, 2511-2517. PubMed  Europe PubMed DOI  I
  70. Yang,W., Wang,L. and Paschen,W.
    Development of a High-Throughput Screening Assay for Inhibitors of Small Ubiquitin-Like Modifier Proteases
    J Biomol Screen (2013) 18, 621-628. PubMed  Europe PubMed DOI  A
    71. 2012
  71. Cai,R., Yu,T., Huang,C., Xia,X., Liu,X., Gu,J., Xue,S., Yeh,E.T. and Cheng,J.
    SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1alpha
    J Biol Chem (2012) 287, 44464-44470. PubMed  Europe PubMed DOI
  72. Chen,Y., Wen,D., Huang,Z., Huang,M., Luo,Y., Liu,B., Lu,H., Wu,Y., Peng,Y. and Zhang,J.
    2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: virtual screening, synthesis and biological evaluation
    Bioorg Med Chem Lett (2012) 22, 6867-6870. PubMed  Europe PubMed DOI  I
  73. Era,S., Abe,T., Arakawa,H., Kobayashi,S., Szakal,B., Yoshikawa,Y., Motegi,A., Takeda,S. and Branzei,D.
    The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment
    Biochem Biophys Res Commun (2012) 426, 310-316. PubMed  Europe PubMed DOI  K
  74. Huang,B.B., Gao,Q.M., Liang,W., Xiu,B., Zhang,W.J. and Liang,A.B.
    Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells
    Asian Pac J Cancer Prev (2012) 13, 2045-2049. PubMed  Europe PubMed DOI  K
  75. Huang,X., Wu,J. and Cheng,J.K.
    Role of SUMO-specific protease 1 in pathogenesis of atherosclerosis
    J Shanghai Jiaotong Univ Med Sci (2012) 32, 1056-1061. DOI  K
  76. Ishihara,K., Fatma,N., Bhargavan,B., Chhunchha,B., Kubo,E., Dey,S., Takamura,Y., Kumar,A. and Singh,D.P.
    Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response
    FEBS J (2012) 279, 3048-3070. PubMed  Europe PubMed DOI
  77. Liu,Y., Song,Y., Madahar,V. and Liao,J.
    Quantitative Forster resonance energy transfer analysis for kinetic determinations of SUMO-specific protease
    Anal Biochem (2012) 422, 14-21. PubMed  Europe PubMed DOI  A
  78. Uno,M., Koma,Y., Ban,H.S. and Nakamura,H.
    Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
    Bioorg Med Chem Lett (2012) 22, 5169-5173. PubMed  Europe PubMed DOI  I
  79. Van Nguyen,T., Angkasekwinai,P., Dou,H., Lin,F.M., Lu,L.S., Cheng,J., Chin,Y.E., Dong,C. and Yeh,E.T.
    SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation
    Mol Cell (2012) 45, 210-221. PubMed  Europe PubMed DOI  PMC  EPMC
  80. Yeh,E.T.H. and Dou,H.
    SENP1 and SENP2 peptidases
    [ISSN:978-0-12-407743-0] (2012) 3, 2365-2370. DOI
    81. 2011
  81. Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M.
    Development of small molecule inhibitors and probes of human SUMO deconjugating proteases
    Chem Biol (2011) 18, 722-732. PubMed  Europe PubMed DOI  I
  82. Rimsa,V., Eadsforth,T. and Hunter,W.N.
    The role of Co2+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols
    Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 67, 442-445. PubMed  Europe PubMed DOI
  83. Satakarni,M. and Curtis,R.
    Production of recombinant peptides as fusions with SUMO
    Protein Expr Purif (2011) 78, 113-119. PubMed  Europe PubMed DOI
  84. Xu,Y., Li,J., Zuo,Y., Deng,J., Wang,L.S. and Chen,G.Q.
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