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Literature for peptidase C48.002: SENP1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Hui,Y., Xia,K., Zhong,J., Zhang,Y., Qiu,Q., Chen,Z., Wang,L. and Liu,X.
    SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1alpha
    J Cell Mol Med28, e70043-e70043. PubMed  Europe PubMed DOI
  2. Ikeda,Y., Yuki,R., Saito,Y. and Nakayama,Y.
    DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity
    FASEB J38, e70261-e70261. PubMed  Europe PubMed DOI  K
  3. Kang,L., Wang,X., Wang,J., Guo,J., Zhang,W. and Lei,R.
    SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription
    Biochim Biophys Acta Gen Subj1868, 130500-130500. PubMed  Europe PubMed DOI  K
  4. Qi,J., Yan,L., Sun,J., Huang,C., Su,B., Cheng,J. and Shen,L.
    SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5
    Proc Natl Acad Sci U S A121, e2314619121-e2314619121. PubMed  Europe PubMed DOI
  5. Stevens,T.A., Tomaleri,G.P., Hazu,M., Wei,S., Nguyen,V.N., DeKalb,C., Voorhees,R.M. and Pleiner,T.
    A nanobody-based strategy for rapid and scalable purification of human protein complexes
    Nat Protoc19, 127-158. PubMed  Europe PubMed DOI
  6. Xu,X., Mao,Y., Feng,Z., Dai,F., Gu,T. and Zheng,J.
    SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1
    Oncol Rep51, PubMed  Europe PubMed DOI
  7. Zeng,W., Wang,L., Wang,C., Xiong,X., Huang,Q., Chen,S., Liu,C., Liu,W., Wang,Y. and Huang,Q.
    SENP1 prevents high fat diet-induced non-alcoholic fatty liver diseases by regulating mitochondrial dynamics
    Biochim Biophys Acta Mol Basis Dis1871, 167527-167527. PubMed  Europe PubMed DOI
    8. 2023
  8. Dai,T., Zhang,L., Ran,Y., Zhang,M., Yang,B., Lu,H., Lin,S., Zhang,L. and Zhou,F.
    MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
    Nat Struct Mol Biol30, 785-799. PubMed  Europe PubMed DOI
  9. Lemma,R.B., Ledsaak,M., Fuglerud,B.M., Rodriguez-Castaneda,F., Eskeland,R. and Gabrielsen,O.S.
    MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape
    J Biol Chem299, 105062-105062. PubMed  Europe PubMed DOI  K
  10. Liu,W., Wang,Y., Bozi,L.H.M., Fischer,P.D., Jedrychowski,M.P., Xiao,H., Wu,T., Darabedian,N., He,X., Mills,E.L., Burger,N., Shin,S., Reddy,A., Sprenger,H.G., Tran,N., Winther,S., Hinshaw,S.M., Shen,J., Seo,H.S., Song,K., Xu,A.Z., Sebastian,L., Zhao,J.J., Dhe-Paganon,S., Che,J., Gygi,S.P., Arthanari,H. and Chouchani,E.T.
    Lactate regulates cell cycle by remodelling the anaphase promoting complex
    Nature616, 790-797. PubMed  Europe PubMed DOI
  11. Wei,M., Huang,X., Liao,L., Tian,Y. and Zheng,X.
    SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer
    Cancer Res83, 2908-2923. PubMed  Europe PubMed DOI
  12. Xu,M., Wang,S., Zhan,Q. and Lin,Y.
    Conditional protein splicing triggered by SUMO protease
    Biochem Biophys Res Commun655, 44-49. PubMed  Europe PubMed DOI
  13. Zhang,R., Liu,Q., Lyu,C., Gao,X. and Ma,W.
    Knockdown SENP1 Suppressed the Angiogenic Potential of Mesenchymal Stem Cells by Impacting CXCR4-Regulated MRTF-A SUMOylation and CCN1 Expression
    Biomedicines11, PubMed  Europe PubMed DOI  K
    14. 2022
  14. Bailly,C.
    Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora
    Bioorg Med Chem70, 116935-116935. PubMed  Europe PubMed DOI  V  I
  15. Brand,M., Bommeli,E.B., Rutimann,M., Lindenmann,U. and Riedl,R.
    Discovery of a Dual SENP1 and SENP2 Inhibitor
    Int J Mol Sci23, PubMed  Europe PubMed DOI  I
  16. Wang,K., Xiong,J., Lu,Y., Wang,L. and Tian,T.
    SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization
    FEBS J PubMed  Europe PubMed DOI
  17. Wei,H., Guo,J., Sun,X., Gou,W., Ning,H., Shang,H., Liu,Q., Hou,W. and Li,Y.
    Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study
    J Nat Prod85, 1248-1255. PubMed  Europe PubMed DOI  I
  18. Wei,J., Wang,H., Zheng,Q., Zhang,J., Chen,Z., Wang,J., Ouyang,L. and Wang,Y.
    Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers
    Eur J Med Chem241, 114650-114650. PubMed  Europe PubMed DOI  V
  19. Yan,L., Zhang,T., Wang,K., Chen,Z., Yang,Y., Shan,B., Sun,Q., Zhang,M., Zhang,Y., Zhong,Y., Liu,N., Gu,J. and Xu,D.
    SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
    Nat Commun13, 7153-7153. PubMed  Europe PubMed DOI
    20. 2021
  20. Goossens,J.F., Goossens,L. and Bailly,C.
    Hinokiflavone and Related C-O-C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action
    Nat Prod Bioprospect PubMed  Europe PubMed DOI  V  I
  21. Li,J., Wu,R., Yung,M.M.H., Sun,J., Li,Z., Yang,H., Zhang,Y., Liu,S.S., Cheung,A.N.Y., Ngan,H.Y.S., Braisted,J.C., Zheng,W., Wei,H., Gao,Y., Nemes,P., Pei,H., Chan,D.W., Li,Y. and Zhu,W.
    SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance
    Cell Death Dis12, 341-341. PubMed  Europe PubMed DOI
  22. Li,Y.Y., Cen,H., Gong,B.N., Mai,S., Wang,Q.L., Mou,S. and Li,Y.
    TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity
    Front Cell Dev Biol9, 789348-789348. PubMed  Europe PubMed DOI
  23. Qing,Z., Huang,H., Yang,S., Lin,J., Zeng,Z., Duan,J., Yuan,B. and Ming,T.
    Hypoxia maintains the fenestration of liver sinusoidal endothelial cells and promotes their proliferation through the SENP1/HIF-1alpha/VEGF signaling axis
    Biochem Biophys Res Commun540, 42-50. PubMed  Europe PubMed DOI
  24. Shangguan,X., He,J., Ma,Z., Zhang,W., Ji,Y., Shen,K., Yue,Z., Li,W., Xin,Z., Zheng,Q., Cao,Y., Pan,J., Dong,B., Cheng,J., Wang,Q. and Xue,W.
    SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
    Nat Commun12, 1812-1812. PubMed  Europe PubMed DOI
  25. Silveirinha,V.C., Lin,H., Tanifuji,S., Mochida,S., Cottrell,G.S., Cimarosti,H. and Stephens,G.J.
    CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways
    Cell Calcium93, 102326-102326. PubMed  Europe PubMed DOI
  26. Wang,J.Q., Lin,Z.C., Li,L.L., Zhang,S.F., Li,W.H., Liu,W., Song,B.L. and Luo,J.
    SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1
    J Biol Chem296, 100032-100032. PubMed  Europe PubMed DOI
    27. 2020
  27. Chauhan,K.M., Chen,Y., Chen,Y., Liu,A.T., Sun,X.X. and Dai,M.S.
    The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity
    J Cell Biochem PubMed  Europe PubMed DOI
  28. Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T. and Salmona,M.
    Neuronal Localization of SENP Proteins with Super Resolution Microscopy
    Brain Sci10, PubMed  Europe PubMed DOI
  29. Islam,M.R., Choi,S., Muthamilselvan,T., Shin,K. and Hwang,I.
    In vivo removal of N-terminal fusion domains from recombinant target proteins produced in Nicotiana benthamiana
    Front Plant Sci11, 440-440. PubMed  Europe PubMed DOI
  30. Lindenmann,U., Brand,M., Gall,F., Frasson,D., Hunziker,L., Kroslakova,I., Sievers,M. and Riedl,R.
    Discovery of a class of potent and selective non-competitive sentrin-specific protease 1 inhibitors
    ChemMedChem15, 675-679. PubMed  Europe PubMed DOI  I
  31. Yu,Y., Chen,Y., Liu,K., Cheng,J. and Tu,J.
    SUMOylation enhances the activity of IDH2 under oxidative stress
    Biochem Biophys Res Commun532, 591-597. PubMed  Europe PubMed DOI
    32. 2019
  32. Ambaye,N.D.
    Noncovalent structure of SENP1 in complex with SUMO2
    Acta Crystallogr F Struct Biol Commun75, 332-339. PubMed  Europe PubMed DOI  S
  33. Huang,X., Zuo,Y., Wang,X., Wu,X., Tan,H., Fan,Q., Dong,B., Xue,W., Chen,G.Q. and Cheng,J.
    SUMO-Specific protease 1 is critical for myeloid-derived suppressor cell development and function
    Cancer Res79, 3891-3902. PubMed  Europe PubMed DOI
  34. Lee,A., Zhu,Y., Sabo,Y. and Goff,S.P.
    Embryonic cells redistribute SUMO1 upon forced SUMO1 overexpression
    MBio10, PubMed  Europe PubMed DOI
    35. 2018
  35. Ambaye,N., Chen,C.H., Khanna,S., Li,Y.J. and Chen,Y.
    Streptonigrin inhibits SENP1 and reduces the protein level of hypoxia-inducible factor 1alpha (HIF1alpha) in cells
    Biochemistry57, 1807-1813. PubMed  Europe PubMed DOI  I
  36. Jiao,D., Wu,M., Ji,L., Liu,F. and Liu,Y.
    microRNA-186 suppresses cell proliferation and metastasis through targeting sentrin-specific protease 1 in renal cell carcinoma
    Oncol Res26, 249-259. PubMed  Europe PubMed DOI  K
  37. Rodriguez-Castaneda,F., Lemma,R.B., Cuervo,I., Bengtsen,M., Moen,L.M., Ledsaak,M., Eskeland,R. and Gabrielsen,O.S.
    The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression
    J Biol Chem293, 15439-15454. PubMed  Europe PubMed DOI
  38. Sun,X.X., Chen,Y., Su,Y., Wang,X., Chauhan,K.M., Liang,J., Daniel,C.J., Sears,R.C. and Dai,M.S.
    SUMO protease SENP1 deSUMOylates and stabilizes c-Myc
    Proc Natl Acad Sci U S A115, 10983-10988. PubMed  Europe PubMed DOI
  39. Zhou,G.Q., Han,F., Shi,Z.L., Yu,L., Li,X.F., Yu,C., Shen,C.L., Wan,D.W., Zhu,X.G., Li,R. and He,S.B.
    MiR-133a-3p targets SUMO-specific protease 1 to inhibit cell proliferation and cell cycle progress in colorectal cancer
    Oncol Res26, 795-800. PubMed  Europe PubMed DOI
    40. 2017
  40. Bawa-Khalfe,T., Yang,F.M., Ritho,J., Lin,H.K., Cheng,J. and Yeh,E.T.
    SENP1 regulates PTEN stability to dictate prostate cancer development
    Oncotarget8, 17651-17664. PubMed  Europe PubMed DOI
    41. 2016
  41. Chen,Y.-Y., Sun,J.-L., Li,S., Zhang,J. and Wu,Y.-L.
    Preliminary study on the synthesis and biological activity of small molecule inhibitor JK043 of SUMO-specific protease 1
    J Shanghai Jiaotong Univ Med Sci36, 224-228. DOI  I
  42. Dong,B., Gao,Y., Kang,X., Gao,H., Zhang,J., Guo,H., You,M.J., Xue,W., Cheng,J. and Huang,Y.
    SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis
    Oncotarget7, 80435-80449. PubMed  Europe PubMed DOI
  43. Kunz,K., Wagner,K., Mendler,L., Holper,S., Dehne,N. and Muller,S.
    SUMO signaling by hypoxic inactivation of SUMO-specific isopeptidases
    Cell Rep16, 3075-3086. PubMed  Europe PubMed DOI
  44. Mendes,A.V., Grou,C.P., Azevedo,J.E. and Pinto,M.P.
    Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases
    Biochim Biophys Acta1863, 139-147. PubMed  Europe PubMed DOI
  45. Mirecka,A., Morawiec,Z. and Wozniak,K.
    Genetic polymorphism of SUMO-specific cysteine proteases - SENP1 and SENP2 in breast cancer
    Pathol Oncol Res22, 817-823. PubMed  Europe PubMed DOI  M
  46. Wang,F.-F., Liu,M.-Z., Sui,Y., Cao,Q., Yan,B., Jin,M.-L. and Mo,X.
    Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia
    Oncol Lett12, 3755-3762. PubMed  Europe PubMed DOI  K
  47. Wang,Z., Jin,J., Zhang,J., Wang,L. and Cao,J.
    Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells
    Oncol Rep36, 2071-2078. PubMed  Europe PubMed DOI  K
  48. Wu,J., Lei,H., Zhang,J., Chen,X., Tang,C., Wang,W., Xu,H., Xiao,W., Gu,W. and Wu,Y.
    Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation
    Oncotarget7, 58995-59005. PubMed  Europe PubMed DOI  I
  49. Xie,W., Wang,Z., Zhang,J., Wang,L., Zhao,Y. and Zhou,H.
    Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitors
    Bioorg Med Chem Lett26, 2124-2128. PubMed  Europe PubMed DOI  A
  50. Yoshioka,Y., Namiki,D., Makiuchi,M., Sugaya,K., Onose,J., Ashida,H. and Abe,N.
    Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-alpha production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity
    Bioorg Med Chem Lett26, 4237-4240. PubMed  Europe PubMed DOI  I
    51. 2015
  51. Li,Y.M., Xu,C.S., Li,Z.Y. and Chen,X.
    [Effects of SUMO specific protease 1 on hPXR-mediated P-gp gene expression]
    Yao Xue Xue Bao50, 1192-1196. PubMed  Europe PubMed
  52. Xu,J., Sun,H.Y., Xiao,F.J., Wang,H., Yang,Y., Wang,L., Gao,C.J., Guo,Z.K., Wu,C.T. and Wang,L.S.
    SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-kappaB signaling
    Biochem Biophys Res Commun460, 409-415. PubMed  Europe PubMed DOI  K
    53. 2014
  53. Chen,C.H., Namanja,A.T. and Chen,Y.
    Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding
    Nat Commun5, 4968-4968. PubMed  Europe PubMed DOI
  54. Chow,K.-H., Elgort,S., Dasso,M., Powers,M.A. and Ullman,K.S.
    The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
    Mol Biol Cell25, 160-168. PubMed  Europe PubMed DOI
  55. Gu,J., Fan,Y., Liu,X., Zhou,L., Cheng,J., Cai,R. and Xue,S.
    SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1alpha-dependent pathway
    Cardiovasc Res104, 83-92. PubMed  Europe PubMed DOI
  56. Lee,W.P., Jena,S., Doherty,D., Ventakesh,J., Schimdt,J., Furmick,J., Widener,T., Lemau,J., Jurutka,P.W. and Thompson,P.D.
    Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling
    PLoS ONE9, e89506-e89506. PubMed  Europe PubMed DOI
  57. Liu,B., Wang,T., Mei,W., Li,D., Cai,R., Zuo,Y. and Cheng,J.
    Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation
    J Biol Chem289, 22358-22364. PubMed  Europe PubMed DOI
    58. 2013
  58. Jiang,L., Liu,Y., Song,Y., Saavedra,A.N., Pan,S., Xiang,W. and Liao,J.
    Internal calibration Forster resonance energy transfer assay: a real-time approach for determining protease kinetics
    Sensors13, 4553-4570. PubMed  Europe PubMed DOI  A
  59. Li,S., Wang,M., Ao,X., Chang,A.K., Yang,C., Zhao,F., Bi,H., Liu,Y., Xiao,L. and Wu,H.
    CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha
    Oncogene32, 4883-4891. PubMed  Europe PubMed DOI
  60. Liu,Y. and Liao,J.
    Quantitative FRET (Forster resonance energy transfer) analysis for SENP1 protease kinetics determination
    J Vis Expe4430-e4430. PubMed  Europe PubMed DOI  A
  61. Obata,S., Yuasa,E., Seki,D., Kitano,T. and Saitoh,H.
    Molecular cloning and bacterial expression of the catalytic domain of the SENP1 gene of Oryzias latipes
    Biosci Biotechnol Biochem77, 1788-1791. PubMed  Europe PubMed DOI
  62. Shi,T., Han,Y., Li,W., Zhao,Y., Liu,Y., Huang,Z., Lu,S. and Zhang,J.
    Exploring the desumoylation process of SENP1: a study combined MD simulations with QM/MM calculations on SENP1-SUMO1-RanGAP1
    J Chem Inf Model53, 2360-2368. PubMed  Europe PubMed DOI
  63. Sommer,S., Weikart,N.D., Linne,U. and Mootz,H.D.
    Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition
    Bioorg Med Chem21, 2511-2517. PubMed  Europe PubMed DOI  I
  64. Yang,W., Wang,L. and Paschen,W.
    Development of a High-Throughput Screening Assay for Inhibitors of Small Ubiquitin-Like Modifier Proteases
    J Biomol Screen18, 621-628. PubMed  Europe PubMed DOI  A
    65. 2012
  65. Cai,R., Yu,T., Huang,C., Xia,X., Liu,X., Gu,J., Xue,S., Yeh,E.T. and Cheng,J.
    SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1alpha
    J Biol Chem287, 44464-44470. PubMed  Europe PubMed DOI
  66. Chen,Y., Wen,D., Huang,Z., Huang,M., Luo,Y., Liu,B., Lu,H., Wu,Y., Peng,Y. and Zhang,J.
    2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: virtual screening, synthesis and biological evaluation
    Bioorg Med Chem Lett22, 6867-6870. PubMed  Europe PubMed DOI  I
  67. Era,S., Abe,T., Arakawa,H., Kobayashi,S., Szakal,B., Yoshikawa,Y., Motegi,A., Takeda,S. and Branzei,D.
    The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment
    Biochem Biophys Res Commun426, 310-316. PubMed  Europe PubMed DOI  K
  68. Huang,B.B., Gao,Q.M., Liang,W., Xiu,B., Zhang,W.J. and Liang,A.B.
    Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells
    Asian Pac J Cancer Prev13, 2045-2049. PubMed  Europe PubMed DOI  K
  69. Huang,X., Wu,J. and Cheng,J.K.
    Role of SUMO-specific protease 1 in pathogenesis of atherosclerosis
    J Shanghai Jiaotong Univ Med Sci32, 1056-1061. DOI  K
  70. Ishihara,K., Fatma,N., Bhargavan,B., Chhunchha,B., Kubo,E., Dey,S., Takamura,Y., Kumar,A. and Singh,D.P.
    Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response
    FEBS J279, 3048-3070. PubMed  Europe PubMed DOI
  71. Liu,Y., Song,Y., Madahar,V. and Liao,J.
    Quantitative Forster resonance energy transfer analysis for kinetic determinations of SUMO-specific protease
    Anal Biochem422, 14-21. PubMed  Europe PubMed DOI  A
  72. Uno,M., Koma,Y., Ban,H.S. and Nakamura,H.
    Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
    Bioorg Med Chem Lett22, 5169-5173. PubMed  Europe PubMed DOI  I
  73. Van Nguyen,T., Angkasekwinai,P., Dou,H., Lin,F.M., Lu,L.S., Cheng,J., Chin,Y.E., Dong,C. and Yeh,E.T.
    SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation
    Mol Cell45, 210-221. PubMed  Europe PubMed DOI
  74. Yeh,E.T.H. and Dou,H.
    SENP1 and SENP2 peptidases
    [ISSN:978-0-12-407743-0]3, 2365-2370. DOI
    75. 2011
  75. Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M.
    Development of small molecule inhibitors and probes of human SUMO deconjugating proteases
    Chem Biol18, 722-732. PubMed  Europe PubMed DOI  I
  76. Rimsa,V., Eadsforth,T. and Hunter,W.N.
    The role of Co2+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols
    Acta Crystallogr Sect F Struct Biol Cryst Commun67, 442-445. PubMed  Europe PubMed DOI
  77. Satakarni,M. and Curtis,R.
    Production of recombinant peptides as fusions with SUMO
    Protein Expr Purif78, 113-119. PubMed  Europe PubMed DOI
  78. Xu,Y., Li,J., Zuo,Y., Deng,J., Wang,L.S. and Chen,G.Q.
    SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors
    Cancer Lett309, 78-84. PubMed  Europe PubMed DOI  K
    79. 2010
  79. Bawa-Khalfe,T. and Yeh,E.T.H.
    SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression
    Genes Cancer1, 748-752. PubMed  Europe PubMed DOI  T
  80. Bawa-Khalfe,T., Cheng,J., Lin,S.H., Ittmann,M.M. and Yeh,E.T.
    SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms
    J Biol Chem285, 25859-25866. PubMed  Europe PubMed DOI
  81. Witty,J., Aguilar-Martinez,E. and Sharrocks,A.D.
    SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
    Biochem J428, 247-254. PubMed  Europe PubMed DOI
  82. Xu,Y., Zuo,Y., Zhang,H., Kang,X., Yue,F., Yi,Z., Liu,M., Yeh,E.T., Chen,G. and Cheng,J.
    Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis
    J Biol Chem285, 36682-36688. PubMed  Europe PubMed DOI
  83. Yu,L., Ji,W., Zhang,H., Renda,M.J., He,Y., Lin,S., Cheng,E.C., Chen,H., Krause,D.S. and Min,W.
    SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
    J Exp Med207, 1183-1195. PubMed  Europe PubMed DOI  K
  84. Zhao,X.Y., Chen,T.T., Xia,L., Guo,M., Xu,Y., Yue,F., Jiang,Y., Chen,G.Q. and Zhao,K.W.
    Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells
    Carcinogenesis31, 1367-1375. PubMed  Europe PubMed DOI  K
    85. 2009
  85. Guo,B. and Sharrocks,A.D.
    Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3
    Mol Cell Biol29, 3204-3218. PubMed  Europe PubMed DOI
  86. Kaikkonen,S., Jaaskelainen,T., Karvonen,U., Rytinki,M.M., Makkonen,H., Gioeli,D., Paschal,B.M. and Palvimo,J.J.
    SUMO-Specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells
    Mol Endocrinol23, 292-307. PubMed  Europe PubMed DOI
  87. Kruse,M., Schulze-Bahr,E., Corfield,V., Beckmann,A., Stallmeyer,B., Kurtbay,G., Ohmert,I., Schulze-Bahr,E., Brink,P. and Pongs,O.
    Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I
    J Clin Invest119, 2737-2744. PubMed  Europe PubMed DOI
  88. Wang,Y., Mukhopadhyay,D., Mathew,S., Hasebe,T., Heimeier,R.A., Azuma,Y., Kolli,N., Shi,Y.B., Wilkinson,K.D. and Dasso,M.
    Identification and developmental expression of Xenopus laevis SUMO proteases
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