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Literature for peptidase C48.002: SENP1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bragado,L., Pozzi,B., Beckerman,I., Magalnik,M. and Srebrow,A.<br>SUMO conjugation to promoter-proximal sequence elements-associated proteins impacts on snRNA transcription<br>Proc Natl Acad Sci U S A (2025) 122, e2417409122-e2417409122. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Feng,X., Wu,G. and Zeng,Q.<br>SENP1: A perspective from immune cells to disease (Review)<br>Oncol Rep (2025) 54 PubMed  Europe PubMed DOI  PMC  EPMC
  3. Jiang,K., Yang,W., Huang,J., Tan,X., Liu,Y., Tu,S. and Luo,J.<br>SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance<br>Int J Mol Med (2025) 56 PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Zou,J., Chen,J., Deng,L., Xu,B., Yu,T., Wang,J. and He,C.<br>Mechanistic Insights into SENP1 and OCT4 Interaction in Promoting Drug Resistance and Stem Cell Features in Colon Cancer<br>Am J Physiol Cell Physiol (2025) PubMed  Europe PubMed DOI  K
    5. 2024
  5. Hui,Y., Xia,K., Zhong,J., Zhang,Y., Qiu,Q., Chen,Z., Wang,L. and Liu,X.<br>SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1alpha<br>J Cell Mol Med (2024) 28, e70043-e70043. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Ikeda,Y., Yuki,R., Saito,Y. and Nakayama,Y.<br>DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity<br>FASEB J (2024) 38, e70261-e70261. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Kang,L., Wang,X., Wang,J., Guo,J., Zhang,W. and Lei,R.<br>SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription<br>Biochim Biophys Acta Gen Subj (2024) 1868, 130500-130500. PubMed  Europe PubMed DOI  K
  8. Lin,H., Suzuki,K., Smith,N., Li,X., Nalbach,L., Fuentes,S., Spigelman,A.F., Dai,X.Q., Bautista,A., Ferdaoussi,M., Aggarwal,S., Pepper,A.R., Roma,L.P., Ampofo,E., Li,W.H. and MacDonald,P.E.<br>A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding<br>Nat Commun (2024) 15, 334-334. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Qi,J., Yan,L., Sun,J., Huang,C., Su,B., Cheng,J. and Shen,L.<br>SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5<br>Proc Natl Acad Sci U S A (2024) 121, e2314619121-e2314619121. PubMed  Europe PubMed DOI
  10. Stevens,T.A., Tomaleri,G.P., Hazu,M., Wei,S., Nguyen,V.N., DeKalb,C., Voorhees,R.M. and Pleiner,T.<br>A nanobody-based strategy for rapid and scalable purification of human protein complexes<br>Nat Protoc (2024) 19, 127-158. PubMed  Europe PubMed DOI
  11. Xu,X., Mao,Y., Feng,Z., Dai,F., Gu,T. and Zheng,J.<br>SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1<br>Oncol Rep (2024) 51 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Zeng,W., Wang,L., Wang,C., Xiong,X., Huang,Q., Chen,S., Liu,C., Liu,W., Wang,Y. and Huang,Q.<br>SENP1 prevents high fat diet-induced non-alcoholic fatty liver diseases by regulating mitochondrial dynamics<br>Biochim Biophys Acta Mol Basis Dis (2024) 1871, 167527-167527. PubMed  Europe PubMed DOI
    13. 2023
  13. Dai,T., Zhang,L., Ran,Y., Zhang,M., Yang,B., Lu,H., Lin,S., Zhang,L. and Zhou,F.<br>MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation<br>Nat Struct Mol Biol (2023) 30, 785-799. PubMed  Europe PubMed DOI
  14. Lemma,R.B., Ledsaak,M., Fuglerud,B.M., Rodriguez-Castaneda,F., Eskeland,R. and Gabrielsen,O.S.<br>MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape<br>J Biol Chem (2023) 299, 105062-105062. PubMed  Europe PubMed DOI  PMC  EPMC  K
  15. Liu,W., Wang,Y., Bozi,L.H.M., Fischer,P.D., Jedrychowski,M.P., Xiao,H., Wu,T., Darabedian,N., He,X., Mills,E.L., Burger,N., Shin,S., Reddy,A., Sprenger,H.G., Tran,N., Winther,S., Hinshaw,S.M., Shen,J., Seo,H.S., Song,K., Xu,A.Z., Sebastian,L., Zhao,J.J., Dhe-Paganon,S., Che,J., Gygi,S.P., Arthanari,H. and Chouchani,E.T.<br>Lactate regulates cell cycle by remodelling the anaphase promoting complex<br>Nature (2023) 616, 790-797. PubMed  Europe PubMed DOI
  16. Wei,M., Huang,X., Liao,L., Tian,Y. and Zheng,X.<br>SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer<br>Cancer Res (2023) 83, 2908-2923. PubMed  Europe PubMed DOI
  17. Xu,M., Wang,S., Zhan,Q. and Lin,Y.<br>Conditional protein splicing triggered by SUMO protease<br>Biochem Biophys Res Commun (2023) 655, 44-49. PubMed  Europe PubMed DOI
  18. Zhang,R., Liu,Q., Lyu,C., Gao,X. and Ma,W.<br>Knockdown SENP1 Suppressed the Angiogenic Potential of Mesenchymal Stem Cells by Impacting CXCR4-Regulated MRTF-A SUMOylation and CCN1 Expression<br>Biomedicines (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC  K
    19. 2022
  19. Bailly,C.<br>Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora<br>Bioorg Med Chem (2022) 70, 116935-116935. PubMed  Europe PubMed DOI  V  I
  20. Brand,M., Bommeli,E.B., Rutimann,M., Lindenmann,U. and Riedl,R.<br>Discovery of a Dual SENP1 and SENP2 Inhibitor<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Wang,K., Xiong,J., Lu,Y., Wang,L. and Tian,T.<br>SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization<br>FEBS J (2022) PubMed  Europe PubMed DOI
  22. Wei,H., Guo,J., Sun,X., Gou,W., Ning,H., Shang,H., Liu,Q., Hou,W. and Li,Y.<br>Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study<br>J Nat Prod (2022) 85, 1248-1255. PubMed  Europe PubMed DOI  I
  23. Wei,J., Wang,H., Zheng,Q., Zhang,J., Chen,Z., Wang,J., Ouyang,L. and Wang,Y.<br>Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers<br>Eur J Med Chem (2022) 241, 114650-114650. PubMed  Europe PubMed DOI  V
  24. Yan,L., Zhang,T., Wang,K., Chen,Z., Yang,Y., Shan,B., Sun,Q., Zhang,M., Zhang,Y., Zhong,Y., Liu,N., Gu,J. and Xu,D.<br>SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation<br>Nat Commun (2022) 13, 7153-7153. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2021
  25. Goossens,J.F., Goossens,L. and Bailly,C.<br>Hinokiflavone and Related C-O-C-Type Biflavonoids as Anti-cancer Compounds: Properties and Mechanism of Action<br>Nat Prod Bioprospect (2021) PubMed  Europe PubMed DOI  PMC  EPMC  V  I
  26. Li,J., Wu,R., Yung,M.M.H., Sun,J., Li,Z., Yang,H., Zhang,Y., Liu,S.S., Cheung,A.N.Y., Ngan,H.Y.S., Braisted,J.C., Zheng,W., Wei,H., Gao,Y., Nemes,P., Pei,H., Chan,D.W., Li,Y. and Zhu,W.<br>SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance<br>Cell Death Dis (2021) 12, 341-341. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Li,Y.Y., Cen,H., Gong,B.N., Mai,S., Wang,Q.L., Mou,S. and Li,Y.<br>TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity<br>Front Cell Dev Biol (2021) 9, 789348-789348. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Liu,Y., Shen,Y., Song,Y., Xu,L., Perry,P. and Liao,J.<br>Isopeptidase Kinetics Determination by a Real Time and Sensitive qFRET Approach<br>Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  29. Qing,Z., Huang,H., Yang,S., Lin,J., Zeng,Z., Duan,J., Yuan,B. and Ming,T.<br>Hypoxia maintains the fenestration of liver sinusoidal endothelial cells and promotes their proliferation through the SENP1/HIF-1alpha/VEGF signaling axis<br>Biochem Biophys Res Commun (2021) 540, 42-50. PubMed  Europe PubMed DOI
  30. Shangguan,X., He,J., Ma,Z., Zhang,W., Ji,Y., Shen,K., Yue,Z., Li,W., Xin,Z., Zheng,Q., Cao,Y., Pan,J., Dong,B., Cheng,J., Wang,Q. and Xue,W.<br>SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis<br>Nat Commun (2021) 12, 1812-1812. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Silveirinha,V.C., Lin,H., Tanifuji,S., Mochida,S., Cottrell,G.S., Cimarosti,H. and Stephens,G.J.<br>CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways<br>Cell Calcium (2021) 93, 102326-102326. PubMed  Europe PubMed DOI
  32. Wang,J.Q., Lin,Z.C., Li,L.L., Zhang,S.F., Li,W.H., Liu,W., Song,B.L. and Luo,J.<br>SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1<br>J Biol Chem (2021) 296, 100032-100032. PubMed  Europe PubMed DOI
    33. 2020
  33. Chauhan,K.M., Chen,Y., Chen,Y., Liu,A.T., Sun,X.X. and Dai,M.S.<br>The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity<br>J Cell Biochem (2020) PubMed  Europe PubMed DOI
  34. Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T. and Salmona,M.<br>Neuronal Localization of SENP Proteins with Super Resolution Microscopy<br>Brain Sci (2020) 10 PubMed  Europe PubMed DOI
  35. Islam,M.R., Choi,S., Muthamilselvan,T., Shin,K. and Hwang,I.<br>In vivo removal of N-terminal fusion domains from recombinant target proteins produced in Nicotiana benthamiana<br>Front Plant Sci (2020) 11, 440-440. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Lindenmann,U., Brand,M., Gall,F., Frasson,D., Hunziker,L., Kroslakova,I., Sievers,M. and Riedl,R.<br>Discovery of a class of potent and selective non-competitive sentrin-specific protease 1 inhibitors<br>ChemMedChem (2020) 15, 675-679. PubMed  Europe PubMed DOI  I
  37. Yu,Y., Chen,Y., Liu,K., Cheng,J. and Tu,J.<br>SUMOylation enhances the activity of IDH2 under oxidative stress<br>Biochem Biophys Res Commun (2020) 532, 591-597. PubMed  Europe PubMed DOI
    38. 2019
  38. Ambaye,N.D.<br>Noncovalent structure of SENP1 in complex with SUMO2<br>Acta Crystallogr F Struct Biol Commun (2019) 75, 332-339. PubMed  Europe PubMed DOI  S
  39. Huang,X., Zuo,Y., Wang,X., Wu,X., Tan,H., Fan,Q., Dong,B., Xue,W., Chen,G.Q. and Cheng,J.<br>SUMO-Specific protease 1 is critical for myeloid-derived suppressor cell development and function<br>Cancer Res (2019) 79, 3891-3902. PubMed  Europe PubMed DOI
  40. Lee,A., Zhu,Y., Sabo,Y. and Goff,S.P.<br>Embryonic cells redistribute SUMO1 upon forced SUMO1 overexpression<br>MBio (2019) 10 PubMed  Europe PubMed DOI
    41. 2018
  41. Ambaye,N., Chen,C.H., Khanna,S., Li,Y.J. and Chen,Y.<br>Streptonigrin inhibits SENP1 and reduces the protein level of hypoxia-inducible factor 1alpha (HIF1alpha) in cells<br>Biochemistry (2018) 57, 1807-1813. PubMed  Europe PubMed DOI  I
  42. Jiao,D., Wu,M., Ji,L., Liu,F. and Liu,Y.<br>microRNA-186 suppresses cell proliferation and metastasis through targeting sentrin-specific protease 1 in renal cell carcinoma<br>Oncol Res (2018) 26, 249-259. PubMed  Europe PubMed DOI  K
  43. Rodriguez-Castaneda,F., Lemma,R.B., Cuervo,I., Bengtsen,M., Moen,L.M., Ledsaak,M., Eskeland,R. and Gabrielsen,O.S.<br>The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression<br>J Biol Chem (2018) 293, 15439-15454. PubMed  Europe PubMed DOI
  44. Sun,X.X., Chen,Y., Su,Y., Wang,X., Chauhan,K.M., Liang,J., Daniel,C.J., Sears,R.C. and Dai,M.S.<br>SUMO protease SENP1 deSUMOylates and stabilizes c-Myc<br>Proc Natl Acad Sci U S A (2018) 115, 10983-10988. PubMed  Europe PubMed DOI
  45. Zhou,G.Q., Han,F., Shi,Z.L., Yu,L., Li,X.F., Yu,C., Shen,C.L., Wan,D.W., Zhu,X.G., Li,R. and He,S.B.<br>MiR-133a-3p targets SUMO-specific protease 1 to inhibit cell proliferation and cell cycle progress in colorectal cancer<br>Oncol Res (2018) 26, 795-800. PubMed  Europe PubMed DOI
    46. 2017
  46. Bawa-Khalfe,T., Yang,F.M., Ritho,J., Lin,H.K., Cheng,J. and Yeh,E.T.<br>SENP1 regulates PTEN stability to dictate prostate cancer development<br>Oncotarget (2017) 8, 17651-17664. PubMed  Europe PubMed DOI
    47. 2016
  47. Chen,Y.-Y., Sun,J.-L., Li,S., Zhang,J. and Wu,Y.-L.<br>Preliminary study on the synthesis and biological activity of small molecule inhibitor JK043 of SUMO-specific protease 1<br>J Shanghai Jiaotong Univ Med Sci (2016) 36, 224-228. DOI  I
  48. Dong,B., Gao,Y., Kang,X., Gao,H., Zhang,J., Guo,H., You,M.J., Xue,W., Cheng,J. and Huang,Y.<br>SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis<br>Oncotarget (2016) 7, 80435-80449. PubMed  Europe PubMed DOI
  49. Kunz,K., Wagner,K., Mendler,L., Holper,S., Dehne,N. and Muller,S.<br>SUMO signaling by hypoxic inactivation of SUMO-specific isopeptidases<br>Cell Rep (2016) 16, 3075-3086. PubMed  Europe PubMed DOI
  50. Mendes,A.V., Grou,C.P., Azevedo,J.E. and Pinto,M.P.<br>Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases<br>Biochim Biophys Acta (2016) 1863, 139-147. PubMed  Europe PubMed DOI
  51. Mirecka,A., Morawiec,Z. and Wozniak,K.<br>Genetic polymorphism of SUMO-specific cysteine proteases - SENP1 and SENP2 in breast cancer<br>Pathol Oncol Res (2016) 22, 817-823. PubMed  Europe PubMed DOI  M
  52. Wang,F.-F., Liu,M.-Z., Sui,Y., Cao,Q., Yan,B., Jin,M.-L. and Mo,X.<br>Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia<br>Oncol Lett (2016) 12, 3755-3762. PubMed  Europe PubMed DOI  K
  53. Wang,Z., Jin,J., Zhang,J., Wang,L. and Cao,J.<br>Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells<br>Oncol Rep (2016) 36, 2071-2078. PubMed  Europe PubMed DOI  K
  54. Wu,J., Lei,H., Zhang,J., Chen,X., Tang,C., Wang,W., Xu,H., Xiao,W., Gu,W. and Wu,Y.<br>Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation<br>Oncotarget (2016) 7, 58995-59005. PubMed  Europe PubMed DOI  I
  55. Xie,W., Wang,Z., Zhang,J., Wang,L., Zhao,Y. and Zhou,H.<br>Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitors<br>Bioorg Med Chem Lett (2016) 26, 2124-2128. PubMed  Europe PubMed DOI  A
  56. Yoshioka,Y., Namiki,D., Makiuchi,M., Sugaya,K., Onose,J., Ashida,H. and Abe,N.<br>Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-alpha production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity<br>Bioorg Med Chem Lett (2016) 26, 4237-4240. PubMed  Europe PubMed DOI  I
    57. 2015
  57. Li,Y.M., Xu,C.S., Li,Z.Y. and Chen,X.<br>[Effects of SUMO specific protease 1 on hPXR-mediated P-gp gene expression]<br>Yao Xue Xue Bao (2015) 50, 1192-1196. PubMed  Europe PubMed
  58. Xu,J., Sun,H.Y., Xiao,F.J., Wang,H., Yang,Y., Wang,L., Gao,C.J., Guo,Z.K., Wu,C.T. and Wang,L.S.<br>SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-kappaB signaling<br>Biochem Biophys Res Commun (2015) 460, 409-415. PubMed  Europe PubMed DOI  K
    59. 2014
  59. Chen,C.H., Namanja,A.T. and Chen,Y.<br>Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding<br>Nat Commun (2014) 5, 4968-4968. PubMed  Europe PubMed DOI
  60. Chow,K.-H., Elgort,S., Dasso,M., Powers,M.A. and Ullman,K.S.<br>The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function<br>Mol Biol Cell (2014) 25, 160-168. PubMed  Europe PubMed DOI
  61. Gu,J., Fan,Y., Liu,X., Zhou,L., Cheng,J., Cai,R. and Xue,S.<br>SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1alpha-dependent pathway<br>Cardiovasc Res (2014) 104, 83-92. PubMed  Europe PubMed DOI
  62. Lee,W.P., Jena,S., Doherty,D., Ventakesh,J., Schimdt,J., Furmick,J., Widener,T., Lemau,J., Jurutka,P.W. and Thompson,P.D.<br>Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling<br>PLoS ONE (2014) 9, e89506-e89506. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Liu,B., Wang,T., Mei,W., Li,D., Cai,R., Zuo,Y. and Cheng,J.<br>Small ubiquitin-like modifier (SUMO) protein-specific protease 1 de-SUMOylates Sharp-1 protein and controls adipocyte differentiation<br>J Biol Chem (2014) 289, 22358-22364. PubMed  Europe PubMed DOI
    64. 2013
  64. Jiang,L., Liu,Y., Song,Y., Saavedra,A.N., Pan,S., Xiang,W. and Liao,J.<br>Internal calibration Forster resonance energy transfer assay: a real-time approach for determining protease kinetics<br>Sensors (2013) 13, 4553-4570. PubMed  Europe PubMed DOI  A
  65. Li,S., Wang,M., Ao,X., Chang,A.K., Yang,C., Zhao,F., Bi,H., Liu,Y., Xiao,L. and Wu,H.<br>CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha<br>Oncogene (2013) 32, 4883-4891. PubMed  Europe PubMed DOI
  66. Liu,Y. and Liao,J.<br>Quantitative FRET (Forster resonance energy transfer) analysis for SENP1 protease kinetics determination<br>J Vis Exp (2013) , e4430-e4430. PubMed  Europe PubMed DOI  A
  67. Obata,S., Yuasa,E., Seki,D., Kitano,T. and Saitoh,H.<br>Molecular cloning and bacterial expression of the catalytic domain of the SENP1 gene of Oryzias latipes<br>Biosci Biotechnol Biochem (2013) 77, 1788-1791. PubMed  Europe PubMed DOI
  68. Shi,T., Han,Y., Li,W., Zhao,Y., Liu,Y., Huang,Z., Lu,S. and Zhang,J.<br>Exploring the desumoylation process of SENP1: a study combined MD simulations with QM/MM calculations on SENP1-SUMO1-RanGAP1<br>J Chem Inf Model (2013) 53, 2360-2368. PubMed  Europe PubMed DOI
  69. Sommer,S., Weikart,N.D., Linne,U. and Mootz,H.D.<br>Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition<br>Bioorg Med Chem (2013) 21, 2511-2517. PubMed  Europe PubMed DOI  I
  70. Yang,W., Wang,L. and Paschen,W.<br>Development of a High-Throughput Screening Assay for Inhibitors of Small Ubiquitin-Like Modifier Proteases<br>J Biomol Screen (2013) 18, 621-628. PubMed  Europe PubMed DOI  A
    71. 2012
  71. Cai,R., Yu,T., Huang,C., Xia,X., Liu,X., Gu,J., Xue,S., Yeh,E.T. and Cheng,J.<br>SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1alpha<br>J Biol Chem (2012) 287, 44464-44470. PubMed  Europe PubMed DOI
  72. Chen,Y., Wen,D., Huang,Z., Huang,M., Luo,Y., Liu,B., Lu,H., Wu,Y., Peng,Y. and Zhang,J.<br>2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: virtual screening, synthesis and biological evaluation<br>Bioorg Med Chem Lett (2012) 22, 6867-6870. PubMed  Europe PubMed DOI  I
  73. Era,S., Abe,T., Arakawa,H., Kobayashi,S., Szakal,B., Yoshikawa,Y., Motegi,A., Takeda,S. and Branzei,D.<br>The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment<br>Biochem Biophys Res Commun (2012) 426, 310-316. PubMed  Europe PubMed DOI  K
  74. Huang,B.B., Gao,Q.M., Liang,W., Xiu,B., Zhang,W.J. and Liang,A.B.<br>Down-regulation of SENP1 expression increases apoptosis of Burkitt lymphoma cells<br>Asian Pac J Cancer Prev (2012) 13, 2045-2049. PubMed  Europe PubMed DOI  K
  75. Huang,X., Wu,J. and Cheng,J.K.<br>Role of SUMO-specific protease 1 in pathogenesis of atherosclerosis<br>J Shanghai Jiaotong Univ Med Sci (2012) 32, 1056-1061. DOI  K
  76. Ishihara,K., Fatma,N., Bhargavan,B., Chhunchha,B., Kubo,E., Dey,S., Takamura,Y., Kumar,A. and Singh,D.P.<br>Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response<br>FEBS J (2012) 279, 3048-3070. PubMed  Europe PubMed DOI
  77. Liu,Y., Song,Y., Madahar,V. and Liao,J.<br>Quantitative Forster resonance energy transfer analysis for kinetic determinations of SUMO-specific protease<br>Anal Biochem (2012) 422, 14-21. PubMed  Europe PubMed DOI  A
  78. Uno,M., Koma,Y., Ban,H.S. and Nakamura,H.<br>Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors<br>Bioorg Med Chem Lett (2012) 22, 5169-5173. PubMed  Europe PubMed DOI  I
  79. Van Nguyen,T., Angkasekwinai,P., Dou,H., Lin,F.M., Lu,L.S., Cheng,J., Chin,Y.E., Dong,C. and Yeh,E.T.<br>SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation<br>Mol Cell (2012) 45, 210-221. PubMed  Europe PubMed DOI  PMC  EPMC
  80. Yeh,E.T.H. and Dou,H.<br>SENP1 and SENP2 peptidases<br>[ISSN:978-0-12-407743-0] (2012) 3, 2365-2370. DOI
    81. 2011
  81. Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M.<br>Development of small molecule inhibitors and probes of human SUMO deconjugating proteases<br>Chem Biol (2011) 18, 722-732. PubMed  Europe PubMed DOI  I
  82. Rimsa,V., Eadsforth,T. and Hunter,W.N.<br>The role of Co2+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols<br>Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 67, 442-445. PubMed  Europe PubMed DOI
  83. Satakarni,M. and Curtis,R.<br>Production of recombinant peptides as fusions with SUMO<br>Protein Expr Purif (2011) 78, 113-119. PubMed  Europe PubMed DOI
  84. Xu,Y., Li,J., Zuo,Y., Deng,J., Wang,L.S. and Chen,G.Q.<br>SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors<br>Cancer Lett (2011) 309, 78-84. PubMed  Europe PubMed DOI  K
    85. 2010
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