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Literature for peptidase C33.001: equine arteritis virus Nsp2-type cysteine peptidase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Adeyinka,O.S., Barrera,M.D., Metibemu,D.S., Boghdeh,N., Anderson,C.A., Baha,H., Crown,O., Falode,J.A., Bleach,J.L., Bliss,A.R., Hampton,T.P., Ojobor,J.C., Alem,F., Narayanan,A. and Ogungbe,I.V.
    nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice
    ACS Infect Dis (2025) 11, 181-196. PubMed  Europe PubMed DOI
  2. Fu,X., Xu,W., Yang,Y., Li,D., Shi,W., Li,X., Chen,N., Lv,Q., Shi,Y., Xu,J., Xu,J., Yan,Y., Shi,F. and Li,X.
    Diverse strategies utilized by coronaviruses to evade antiviral responses and suppress pyroptosis
    Int J Biol Macromol (2025) 296, 139743-139743. PubMed  Europe PubMed DOI
    3. 2024
  3. Zhao,S., Qian,Q., Chen,X., Lu,Q., Xing,G., Qiao,S., Li,R. and Zhang,G.
    Porcine reproductive and respiratory syndrome virus triggers Golgi apparatus fragmentation-mediated autophagy to facilitate viral self-replication
    J Virol (2024) 98, e0184223-e0184223. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2023
  4. Bailey-Elkin,B.A., Knaap,R.C.M., De Silva,A., Boekhoud,I.M., Mous,S., van Vught,N., Khajehpour,M., van den Born,E., Kikkert,M. and Mark,B.L.
    Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis
    PLoS Pathog (2023) 19, e1011872-e1011872. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Diao,F., Bai,J., Jiang,C., Sun,Y., Gao,Y., Nauwynck,H., Jiang,P. and Liu,X.
    The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1
    J Virol (2023) 97, e0018823-e0018823. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2015
  6. van Kasteren,P.B., Knaap,R.C., van den Elzen,P., Snijder,E.J., Balasuriya,U.B., van den Born,E. and Kikkert,M.
    In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2
    Vet Microbiol (2015) 178, 132-137. PubMed  Europe PubMed DOI
    7. 2014
  7. Deaton,M.K., Spear,A., Faaberg,K.S. and Pegan,S.D.
    The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference
    Virology (2014) 454-455, 247-253. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2013
  8. van Kasteren,P.B., Bailey-Elkin,B.A., James,T.W., Ninaber,D.K., Beugeling,C., Khajehpour,M., Snijder,E.J., Mark,B.L. and Kikkert,M.
    Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells
    Proc Natl Acad Sci U S A (2013) 110, E838-E847. PubMed  Europe PubMed DOI  S
    9. 2012
  9. Kikkert,M., Snijder,E.J. and Gorbalenya,A.E.
    Arterivirus nsp2 cysteine proteinase
    [ISSN:978-0-12-407743-0] (2012) 3, 2210-2215. DOI
  10. Sun,Z., Li,Y., Ransburgh,R., Snijder,E.J. and Fang,Y.
    Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15
    J Virol (2012) 86, 3839-3850. PubMed  Europe PubMed DOI
  11. van Kasteren,P.B., Beugeling,C., Ninaber,D.K., Frias-Staheli,N., van Boheemen,S., Garcia-Sastre,A., Snijder,E.J. and Kikkert,M.
    Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling
    J Virol (2012) 86, 773-785. PubMed  Europe PubMed DOI
    12. 2010
  12. Han,J., Rutherford,M.S. and Faaberg,K.S.
    Proteolytic products of the porcine reproductive and respiratory syndrome virus Nsp2 replicase protein
    J Virol (2010) 84, 10102-10112. PubMed  Europe PubMed DOI
  13. Li,H., Zheng,Z., Zhou,P., Zhang,B., Shi,Z., Hu,Q. and Wang,H.
    The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation
    J Gen Virol (2010) 91, 2947-2958. PubMed  Europe PubMed DOI
  14. Sun,Z., Chen,Z., Lawson,S.R. and Fang,Y.
    The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions
    J Virol (2010) 84, 7832-7846. PubMed  Europe PubMed DOI
    15. 2009
  15. Han,J., Rutherford,M.S. and Faaberg,K.S.
    The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities
    J Virol (2009) 83, 9449-9463. PubMed  Europe PubMed DOI  PMC  EPMC  P
  16. Qu,H., Li,Y., Hou,Y. and Yan,J.
    [Expression and purification of porcine reproductive and respiratory syndrome virus Nsp2 protein and analysis of cleavage activity]
    Wei Sheng Wu Xue Bao (2009) 49, 1502-1509. PubMed  Europe PubMed  P
    17. 2007
  17. Frias-Staheli,N., Giannakopoulos,N.V., Kikkert,M., Taylor,S.L., Bridgen,A., Paragas,J., Richt,J.A., Rowland,R.R., Schmaljohn,C.S., Lenschow,D.J., Snijder,E.J., Garcia-Sastre,A. and Virgin,H.W.
    Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses
    Cell Host Microbe (2007) 2, 404-416. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Han,J., Liu,G., Wang,Y. and Faaberg,K.S.
    Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture
    J Virol (2007) 81, 9878-9890. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2004
  19. Gorbalenya,A.E., Wassenaar,A.L.M. and Snijder,E.J.
    Arterivirus Nsp2 cysteine proteinase
    [ISSN:0-12-079610-4] (2004) 2, 1283-1285.  V
    20. 1995
  20. Palmer,G.A., Kuo,L., Chen,Z., Faaberg,K.S. and Plagemann,P.G.
    Sequence of the genome of lactate dehydrogenase-elevating virus: heterogenicity between strains P and C
    Virology (1995) 209, 637-642. PubMed  Europe PubMed DOI
  21. Snijder,E.J., Wassenaar,A.L., Spaan,W.J. and Gorbalenya,A.E.
    The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases
    J Biol Chem (1995) 270, 16671-16676. PubMed  Europe PubMed DOI

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