Literature for peptidase C33.001: equine arteritis virus Nsp2-type cysteine peptidase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Adeyinka,O.S., Barrera,M.D., Metibemu,D.S., Boghdeh,N., Anderson,C.A., Baha,H., Crown,O., Falode,J.A., Bleach,J.L., Bliss,A.R., Hampton,T.P., Ojobor,J.C., Alem,F., Narayanan,A. and Ogungbe,I.V.
    nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice
    ACS Infect Dis11, 181-196. PubMed  Europe PubMed DOI
  2. 2024
  3. Zhao,S., Qian,Q., Chen,X., Lu,Q., Xing,G., Qiao,S., Li,R. and Zhang,G.
    Porcine reproductive and respiratory syndrome virus triggers Golgi apparatus fragmentation-mediated autophagy to facilitate viral self-replication
    J Virol98, e0184223-e0184223. PubMed  Europe PubMed DOI
  4. 2023
  5. Bailey-Elkin,B.A., Knaap,R.C.M., De Silva,A., Boekhoud,I.M., Mous,S., van Vught,N., Khajehpour,M., van den Born,E., Kikkert,M. and Mark,B.L.
    Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis
    PLoS Pathog19, e1011872-e1011872. PubMed  Europe PubMed DOI
  6. Diao,F., Bai,J., Jiang,C., Sun,Y., Gao,Y., Nauwynck,H., Jiang,P. and Liu,X.
    The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1
    J Virol97, e0018823-e0018823. PubMed  Europe PubMed DOI
  7. 2015
  8. van Kasteren,P.B., Knaap,R.C., van den Elzen,P., Snijder,E.J., Balasuriya,U.B., van den Born,E. and Kikkert,M.
    In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2
    Vet Microbiol178, 132-137. PubMed  Europe PubMed DOI
  9. 2014
  10. Deaton,M.K., Spear,A., Faaberg,K.S. and Pegan,S.D.
    The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference
    Virology454-455, 247-253. PubMed  Europe PubMed DOI
  11. 2013
  12. van Kasteren,P.B., Bailey-Elkin,B.A., James,T.W., Ninaber,D.K., Beugeling,C., Khajehpour,M., Snijder,E.J., Mark,B.L. and Kikkert,M.
    Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells
    Proc Natl Acad Sci U S A110, E838-E847. PubMed  Europe PubMed DOI  S
  13. 2012
  14. Kikkert,M., Snijder,E.J. and Gorbalenya,A.E.
    Arterivirus nsp2 cysteine proteinase
    [ISSN:978-0-12-407743-0]3, 2210-2215. DOI
  15. Sun,Z., Li,Y., Ransburgh,R., Snijder,E.J. and Fang,Y.
    Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15
    J Virol86, 3839-3850. PubMed  Europe PubMed DOI
  16. van Kasteren,P.B., Beugeling,C., Ninaber,D.K., Frias-Staheli,N., van Boheemen,S., Garcia-Sastre,A., Snijder,E.J. and Kikkert,M.
    Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling
    J Virol86, 773-785. PubMed  Europe PubMed DOI
  17. 2010
  18. Han,J., Rutherford,M.S. and Faaberg,K.S.
    Proteolytic products of the porcine reproductive and respiratory syndrome virus Nsp2 replicase protein
    J Virol84, 10102-10112. PubMed  Europe PubMed DOI
  19. Li,H., Zheng,Z., Zhou,P., Zhang,B., Shi,Z., Hu,Q. and Wang,H.
    The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation
    J Gen Virol91, 2947-2958. PubMed  Europe PubMed DOI
  20. Sun,Z., Chen,Z., Lawson,S.R. and Fang,Y.
    The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions
    J Virol84, 7832-7846. PubMed  Europe PubMed DOI
  21. 2009
  22. Han,J., Rutherford,M.S. and Faaberg,K.S.
    The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities
    J Virol83, 9449-9463. PubMed  Europe PubMed DOI  P
  23. Qu,H., Li,Y., Hou,Y. and Yan,J.
    [Expression and purification of porcine reproductive and respiratory syndrome virus Nsp2 protein and analysis of cleavage activity]
    Wei Sheng Wu Xue Bao49, 1502-1509. PubMed  Europe PubMed  P
  24. 2007
  25. Frias-Staheli,N., Giannakopoulos,N.V., Kikkert,M., Taylor,S.L., Bridgen,A., Paragas,J., Richt,J.A., Rowland,R.R., Schmaljohn,C.S., Lenschow,D.J., Snijder,E.J., Garcia-Sastre,A. and Virgin,H.W.
    Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses
    Cell Host Microbe2, 404-416. PubMed  Europe PubMed DOI
  26. Han,J., Liu,G., Wang,Y. and Faaberg,K.S.
    Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture
    J Virol81, 9878-9890. PubMed  Europe PubMed DOI
  27. 2004
  28. Gorbalenya,A.E., Wassenaar,A.L.M. and Snijder,E.J.
    Arterivirus Nsp2 cysteine proteinase
    [ISSN:0-12-079610-4]2, 1283-1285.  V
  29. 1995
  30. Palmer,G.A., Kuo,L., Chen,Z., Faaberg,K.S. and Plagemann,P.G.
    Sequence of the genome of lactate dehydrogenase-elevating virus: heterogenicity between strains P and C
    Virology209, 637-642. PubMed  Europe PubMed DOI
  31. Snijder,E.J., Wassenaar,A.L., Spaan,W.J. and Gorbalenya,A.E.
    The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases
    J Biol Chem270, 16671-16676. PubMed  Europe PubMed DOI