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Literature for peptidase C26.001: gamma-glutamyl hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, M Mutation, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Wang,S.M., Li,M., Wu,W.S., Sun,L.L. and Yan,D.
    The role of transcription factor Sp1 in the regulation of gamma-glutamyl hydrolase gene expression by the rs3758149 polymorphism in CEM/C1 cells
    Pharmazie74, 671-674. PubMed  Europe PubMed DOI  M
    2. 2018
  2. Stamm,R.A., Fazili,Z. and Pfeiffer,C.M.
    Addition of exogenous gamma-glutamyl hydrolase eliminates the need for lengthy incubation of whole-blood lysate for quantitation of folate vitamers by high-performance liquid chromatography-tandem mass spectrometry
    Curr Dev Nutr2, 1-9. PubMed  Europe PubMed DOI
    3. 2013
  3. Chuankhayan,P., Kao,T.T., Lin,C.C., Guan,H.H., Nakagawa,A., Fu,T.F. and Chen,C.J.
    Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish gamma-glutamyl hydrolase
    J Med Chem56, 7625-7635. PubMed  Europe PubMed DOI  S
  4. Kim,S.E., Cole,P.D., Cho,R.C., Ly,A., Ishiguro,L., Sohn,K.J., Croxford,R., Kamen,B.A. and Kim,Y.I.
    gamma-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate
    Br J Cancer109, 2175-2188. PubMed  Europe PubMed DOI
    5. 2012
  5. Chave,K.J.
    gamma-Glutamyl hydrolase
    [ISSN:978-0-12-407743-0]3, 2452-2459. DOI
  6. Koomdee,N., Hongeng,S., Apibal,S. and Pakakasama,S.
    Association between polymorphisms of dihydrofolate reductase and gamma glutamyl hydrolase genes and toxicity of high dose methotrexate in children with acute lymphoblastic leukemia
    Asian Pac J Cancer Prev13, 3461-3464. DOI  M
  7. Zhang,H., Yue,L., Yuan,X., Zheng,M., Hu,C. and Yang,C.
    A novel missense mutation (T191G) identified in gamma-glutamyl hydrolase gene
    Chin J Clin Oncol39, 185-188. DOI  M
    8. 2011
  8. Cheng,H.L., Chiou,S.S., Liao,Y.M., Chen,Y.L. and Wu,S.M.
    Genotyping of single nucleotide polymorphism in gamma-glutamyl hydrolase gene by capillary electrophoresis
    Electrophoresis32, 2021-2027. PubMed  Europe PubMed DOI  M
    9. 2010
  9. Organista-Nava,J., Gomez-Gomez,Y., Saavedra-Herrera,M.V., Rivera-Ramirez,A.B., Teran-Porcayo,M.A., Alarcon-Romero Ldel,C., Illades-Aguiar,B. and Leyva-Vazquez,M.A.
    Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico
    Leuk Res34, 728-732. PubMed  Europe PubMed DOI  M
    10. 2009
  10. Kao,T.T., Chang,W.N., Wu,H.L., Shi,G.Y. and Fu,T.F.
    Recombinant zebrafish {gamma}-glutamyl hydrolase exhibits properties and catalytic activities comparable with those of mammalian enzyme
    Drug Metab Dispos37, 302-309. PubMed  Europe PubMed DOI
    11. 2008
  11. Akhtar,T.A., McQuinn,R.P., Naponelli,V., Gregory,J.F., III, Giovannoni,J.J. and Hanson,A.D.
    Tomato gamma-glutamylhydrolases: expression, characterization, and evidence for heterodimer formation
    Plant Physiol148, 775-785. PubMed  Europe PubMed DOI
  12. Alexander,J.P., Ryan,T.J., Ballou,D.P. and Coward,J.K.
    gamma-Glutamyl hydrolase: kinetic characterization of isopeptide hydrolysis using fluorogenic substrates
    Biochemistry47, 1228-1239. PubMed  Europe PubMed DOI
  13. Coward,J.K. and McGuire,J.J.
    Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target
    Vitam Horm79, 347-373. PubMed  Europe PubMed DOI  T  I
  14. Sakamoto,E., Tsukioka,S., Oie,S., Kobunai,T., Tsujimoto,H., Sakamoto,K., Okayama,Y., Sugimoto,Y., Oka,T., Fukushima,M. and Oka,T.
    Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity
    Biochem Biophys Res Commun365, 801-807. PubMed  Europe PubMed DOI
    15. 2007
  15. Garcia-Bournissen,F., Moghrabi,A. and Krajinovic,M.
    Therapeutic responses in childhood acute lymphoblastic leukemia (ALL) and haplotypes of gamma glutamyl hydrolase (GGH) gene
    Leuk Res31, 1023-1025. PubMed  Europe PubMed DOI
  16. Hayashi,H., Fujimaki,C., Inoue,K., Suzuki,T. and Itoh,K.
    Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population
    Biol Pharm Bull30, 839-841. PubMed  Europe PubMed DOI  M
  17. Shafizadeh,T.B. and Halsted,C.H.
    gamma-Glutamyl hydrolase, not glutamate carboxypeptidase II, hydrolyzes dietary folate in rat small intestine
    J Nutr137, 1149-1153. PubMed  Europe PubMed
    18. 2006
  18. Cheng,Q., Cheng,C., Crews,K.R., Ribeiro,R.C., Pui,C.H., Relling,M.V. and Evans,W.E.
    Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells
    Am J Hum Genet79, 264-274. PubMed  Europe PubMed DOI
  19. Eisele,L.E., Chave,K.J., Lehning,A.C. and Ryan,T.J.
    Characterization of human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer
    Biochim Biophys Acta Proteins Proteom1764, 1479-1486. PubMed  Europe PubMed DOI
  20. [YEAR:10-6-2006]Schneider,E. and Ryan,T.J.
    Gamma-glutamyl hydrolase and drug resistance
    Clin Chim Acta374, 25-32. PubMed  Europe PubMed DOI  V
    21. 2004
  21. Chave,K.J., Galivan,J. and Ryan,T.J.
    gamma-Glutamyl hydrolase
    [ISSN:0-12-079610-4]2, 1396-1399.  V
  22. Cheng,Q., Wu,B., Kager,L., Panetta,J.C., Zheng,J., Pui,C.H., Relling,M.V. and Evans,W.E.
    A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells
    Pharmacogenetics14, 557-567. PubMed  Europe PubMed DOI
  23. Dervieux,T., Kremer,J., Lein,D.O., Capps,R., Barham,R., Meyer,G., Smith,K., Caldwell,J. and Furst,D.E.
    Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis
    Pharmacogenetics14, 733-739. PubMed  Europe PubMed DOI  M
  24. He,P., Varticovski,L., Bowman,E.D., Fukuoka,J., Welsh,J.A., Miura,K., Jen,J., Gabrielson,E., Brambilla,E., Travis,W.D. and Harris,C.C.
    Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray
    Hum Pathol35, 1196-1209. PubMed  Europe PubMed DOI
    25. 2003
  25. [YEAR:13-11-2003]Chave,K.J., Ryan,T.J., Chmura,S.E. and Galivan,J.
    Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms
    Gene319, 167-175. PubMed  Europe PubMed DOI  M
  26. Volk,E.L., Pankuch,J.J., Chave,K.J., Coward,J.K. and Schneider,E.
    A rapid assay for the quantitation of gamma-glutamyl hydrolase using a fluorogenic peptide as substrate
    Biotechniques35, 926-928. PubMed  Europe PubMed  A
  27. [YEAR:17-7-2003]Yin,D., Galivan,J., Ao,W. and Yao,R.
    Characterization of the human gamma-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines
    Gene312, 281-288. PubMed  Europe PubMed DOI
    28. 2002
  28. [YEAR:5-7-2002]Li,H., Ryan,T.J., Chave,K.J. and Van Roey,P.
    Three-dimensional structure of human gamma-glutamyl hydrolase. A class I glutamine amidotransferase adapted for a complex substrate
    J Biol Chem277, 24522-24529. PubMed  Europe PubMed DOI  S
  29. [YEAR:29-5-2002]Masumoto,N., Chen,J. and Sirotnak,F.M.
    Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression
    Gene291, 169-176. PubMed  Europe PubMed DOI
  30. Panetta,J.C., Wall,A., Pui,C.H., Relling,M.V. and Evans,W.E.
    Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity
    Clin Cancer Res8, 2423-2429. PubMed  Europe PubMed
    31. 2001
  31. [YEAR:2-5-2001]Masumoto,N., Esaki,T. and Sirotnak,F.M.
    Additional organizational features of the murine gamma-glutamyl hydrolase gene. Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter
    Gene268, 183-194. PubMed  Europe PubMed DOI
  32. [YEAR:18-6-2001]Pankuch,J.J. and Coward,J.K.
    N-Me-pAB-Glu-gamma-Glu-gamma-Tyr(3-NO(2)): an internally quenched fluorogenic gamma-glutamyl hydrolase substrate
    Bioorg Med Chem Lett11, 1561-1564. PubMed  Europe PubMed DOI  A
    33. 2000
  33. [YEAR:22-12-2000]Chave,K.J., Auger,I.E., Galivan,J. and Ryan,T.J.
    Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma-glutamyl hydrolase
    J Biol Chem275, 40365-40370. PubMed  Europe PubMed DOI
  34. Galivan,J., Ryan,T.J., Chave,K., Rhee,M., Yao,R. and Yin,D.
    Glutamyl hydrolase. Pharmacological role and enzymatic characterization
    Pharmacol Ther85, 207-215. PubMed  Europe PubMed DOI
    35. 1999
  35. [YEAR:1-11-1999]Chave,K.J., Galivan,J. and Ryan,T.J.
    Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase
    Biochem J343, 551-555. PubMed  Europe PubMed DOI
  36. [YEAR:24-6-1999]Esaki,T., Masumoto,N., Hayes,P., Chen,J. and Sirotnak,F.M.
    Organization and structure of the mouse gamma-glutamyl hydrolase gene and the functional identification of its promoter
    Gene234, 93-100. PubMed  Europe PubMed DOI
  37. Rhee,M.S., Ryan,T.J. and Galivan,J.
    Glutamyl hydrolase and the multitargeted antifolate LY231514
    Cancer Chemother Pharmacol44, 427-432. PubMed  Europe PubMed DOI
  38. Rots,M.G., Pieters,R., Peters,G.J., Noordhuis,P., van Zantwijk,C.H., Kaspers,G.J., Hahlen,K., Creutzig,U., Veerman,A.J. and Jansen,G.
    Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
    Blood93, 1677-1683. PubMed  Europe PubMed
  39. [YEAR:1-10-1999]Yin,D., Chave,K.J., Macaluso,C.R., Galivan,J. and Yao,R.
    Structural organization of the human gamma-glutamyl hydrolase gene
    Gene238, 463-470. PubMed  Europe PubMed DOI  M
    40. 1998
  40. [YEAR:28-9-1998]Esaki,T., Roy,K., Yao,R., Galivan,J. and Sirotnak,F.M.
    Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences
    Gene219, 37-44. PubMed  Europe PubMed DOI
  41. Rhee,M.S., Lindau-Shepard,B., Chave,K.J., Galivan,J. and Ryan,T.J.
    Characterization of human cellular gamma-glutamyl hydrolase
    Mol Pharmacol53, 1040-1046. PubMed  Europe PubMed
  42. [YEAR:16-6-1998]Rodriguez,C.E., Holmes,H.M., Mlodnosky,K.L., Lam,V.Q. and Berkman,C.E.
    Evaluation of phosphorus-containing inhibitors of gamma-glutamyl hydrolase
    Bioorg Med Chem Lett8, 1521-1524. PubMed  Europe PubMed DOI  I
    43. 1997
  43. Waltham,M.C., Lin,S., Li,W.W., Goker,E., Gritsman,H., Tong,W.P. and Bertino,J.R.
    Capillary electrophoresis of methotrexate polyglutamates and its application in evaluation of gamma-glutamyl hydrolase activity
    J Chromatogr B Biomed Sci Appl689, 387-392. PubMed  Europe PubMed DOI
  44. Waltham,M.C., Li,W.W., Gritsman,H., Tong,W.P. and Bertino,J.R.
    gamma-Glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists
    Mol Pharmacol51, 825-832. PubMed  Europe PubMed  I
    45. 1996
  45. Van den Hazel,H.B., Kielland-Brandt,M.C. and Winther,J.R.
    Review: biosynthesis and function of yeast vacuolar proteases
    Yeast12, 1-16. PubMed  Europe PubMed DOI  V
  46. Yao,R., Schneider,E., Ryan,T.J. and Galivan,J.
    Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro
    Proc Natl Acad Sci U S A93, 10134-10138. PubMed  Europe PubMed DOI  E
  47. Yao,R., Nimec,Z., Ryan,T.J. and Galivan,J.
    Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase
    J Biol Chem271, 8525-8528. PubMed  Europe PubMed
    48. 1995
  48. Yao,R., Rhee,M.S. and Galivan,J.
    Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells
    Mol Pharmacol48, 505-511. PubMed  Europe PubMed
    49. 1993
  49. Lin,S., Rogiers,S. and Cossins,E.A.
    Gamma-Glutamyl hydrolase from pea cotyledons
    Phytochemistry32, 1109-1117.
  50. Rhee,M.S., Wang,Y., Nair,M.G. and Galivan,J.
    Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity
    Cancer Res53, 2227-2230. PubMed  Europe PubMed
  51. Wang,Y., Nimec,Z., Ryan,T.J., Dias,J.A. and Galivan,J.
    The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells
    Biochim Biophys Acta1164, 227-235. PubMed  Europe PubMed DOI
    52. 1992
  52. Wagh,P.V. and Kalman,T.I.
    A rapid colorimetric assay for gamma-glutamyl hydrolase (conjugase)
    Anal Biochem207, 1-5. PubMed  Europe PubMed DOI
    53. 1987
  53. Krungkrai,J., Yuthavong,Y. and Webster,H.K.
    High-performance liquid chromatographic assay for pteroylpolyglutamate hydrolase
    J Chromatogr417, 47-56. PubMed  Europe PubMed  A
    54. 1986
  54. Samuels,L.L., Goutas,L.J., Priest,D.G., Piper,J.R. and Sirotnak,F.M.
    Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse
    Cancer Res46, 2230-2235. PubMed  Europe PubMed
  55. [YEAR:15-10-1986]Wang,T.T., Chandler,C.J. and Halsted,C.H.
    Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization
    J Biol Chem261, 13551-13555. PubMed  Europe PubMed
    56. 1982
  56. [YEAR:19-3-1982]Priest,D.G., Veronee,C.D., Mangum,M., Bednarek,J.M. and Doig,M.T.
    Comparison of folylpolyglutamate hydrolases of mouse liver, kidney, muscle and brain
    Mol Cell Biochem43, 81-87. PubMed  Europe PubMed DOI
    57. 1981
  57. Horne,D.W., Krumdieck,C.L. and Wagner,C.
    Properties of folic acid gamma-glutamyl hydrolase (conjugase) in rat bile and plasma
    J Nutr111, 442-449. PubMed  Europe PubMed
    58. 1979
  58. Jagerstad,M. and Olsson,I.
    Pteroylpolyglutamate hydrolase of human granulocytes. I. Partial purification and kinetic studies
    Scand J Clin Lab Invest39, 343-349. PubMed  Europe PubMed
    59. 1977
  59. Leichter,J., Butterworth,C.E., Jr. and Krumdieck,C.L.
    Partial purification and some properties of pteroylpolyglutamate hydrolase (conjugase) from chicken pancreas
    Proc Soc Exp Biol Med154, 98-101. PubMed  Europe PubMed
  60. [YEAR:12-4-1977]Rao,K.N. and Noronha,J.M.
    Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-gamma-glutamyl carboxypeptidase. II. Structural studies
    Biochim Biophys Acta481, 608-615. PubMed  Europe PubMed
  61. Rao,K.N. and Noronha,J.M.
    Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-gamma-glutamyl carboxypeptidase. I. Intracellular localization, purification and partial characterization of the enzyme
    Biochim Biophys Acta481, 594-607. PubMed  Europe PubMed
    62. 1976
  62. Eichner,E.R., Loewenstein,J.E. and Cox,E.
    Effect of ethanol on activity of folate conjugase and on serum binding and cellular uptake of radiolabelled folates
    Biochem Soc Trans4, 908-910. PubMed  Europe PubMed
    63. 1975
  63. [YEAR:13-1-1975]Silink,M. and Rowe,P.B.
    The localization of glutamate carboxypeptidase in rat liver lysosomes
    Biochim Biophys Acta381, 28-36. PubMed  Europe PubMed
    64. 1972
  64. Jagerstad,M., Lindstrand,K. and Westesson,A.K.
    Hydrolysis of conjugated folic acid by pancreatic "conjugase"
    Scand J Gastroenterol7, 593-597. PubMed  Europe PubMed
    65. 1970
  65. Bernstein,L.H., Gutstein,S. and Weiner,S.V.
    Gamma glutamyl carboxypeptidase (conjugase), the folic acid-releasing enzyme of intestinal mucosa
    Am J Clin Nutr23, 919-925. PubMed  Europe PubMed
  66. Krumdieck,C.L. and Baugh,C.M.
    Radioactive assay of folic acid polyglutamate conjugase(s)
    Anal Biochem35, 123-129. PubMed  Europe PubMed  A

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