Summary for peptidase C26.001: gamma-glutamyl hydrolase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma


MEROPS Namegamma-glutamyl hydrolase
Other namesconjugase, folate conjugase, gamma-Glu-X carboxypeptidase, lysosomal gamma-glutamyl carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, GGH g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PC >> Subclan PC(C) >> Family C26 >> Subfamily (none) >> C26.001
Holotypegamma-glutamyl hydrolase (Rattus norvegicus), Uniprot accession Q62867 (peptidase unit: 25-293), MERNUM MER0002464
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeCysteine
PeplistIncluded in the Peplist with identifier PL00113
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase
EnzymologyBRENDA database
Activity statushuman: active (Chave et al., 2004)
mouse: active (Priest et al., 1982)
PhysiologyHydrolyses poly-gamma-glutamyl forms of folic acid allowing cellular uptake.
Pathways KEGGFolate biosynthesis
Other databases TREEFAM
Relevant inhibitors acivicin
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
GGH 8q12.23-q13.1 ENSG00000137563 8836 GGH 601509
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ggh 4:A3 ENSMUSG00000028242 14590 MGI:1329035