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Literature for peptidase C19.030: ubiquitin-specific peptidase 18

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: T Target, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. An,Y., Guo,C., Wang,X., Liu,J., Li,Z., Ding,J., Zhang,Q., Zhou,H., Xia,B., Wang,J., Yu,Y., Wan,C., Wang,J. and Dai,J.<br>USP18 Promotes Cholesterol Efflux and Mitigates Atherosclerosis by Deubiquitinating ABCG1<br>J Cell Mol Med (2025) 29, e70320-e70320. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Bonacci,T., Bolhuis,D.L., Brown,N.G. and Emanuele,M.J.<br>Mechanisms of USP18 specificity towards ISG15 revealed by paralog sequence analysis comparison<br>J Biol Chem (2025) , 110288-110288. PubMed  Europe PubMed DOI
  3. Carey,M.M., O'Donovan,T.R., Coveney,C.M. and McKenna,S.L.<br>Inhibition of USP18 in the presence of IFN-alpha elevates apoptosis, autophagy, and chemosensitivity of oesophageal cancer cell lines<br>Exp Cell Res (2025) 452, 114768-114768. PubMed  Europe PubMed DOI  K
  4. Chai,L., Sun,Y., Wang,Y. and Zhao,C.<br>USP18 Confers Paclitaxel Resistance in Non-Small Cell Lung Cancer by Stabilizing SHANK1 Expression Via Deubiquitination<br>J Biochem Mol Toxicol (2025) 39, e70197-e70197. PubMed  Europe PubMed DOI
  5. Cheng,Y., Liu,G., Yu,L., Li,H., Liu,Y., Yang,H. and Zhang,P.<br>A related mechanism for USP18 regulating diabetic cardiomyopathy procession: promoting activity of AKT signaling pathway by improving Notch1 stability<br>Biochem Biophys Res Commun (2025) 784, 152626-152626. PubMed  Europe PubMed DOI
  6. Davis,G.J., Omole,A.O., Jung,Y., Rut,W., Holewinski,R., Suazo,K.F., Kim,H.R., Yang,M., Andresson,T., Drag,M. and Yoo,E.<br>Chemical tools to define and manipulate interferon-inducible Ubl protease USP18<br>Nat Commun. (2025) 16(1):957, 957-957. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Davis,G.J., Omole,A.O., Jung,Y., Rut,W., Holewinski,R., Suazo,K.F., Kim,H.R., Yang,M., Andresson,T., Drag,M. and Yoo,E.<br>Chemical tools to define and manipulate interferon-inducible Ubl protease USP18<br>Nat Commun (2025) 16, 957-957. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Fang,Y., Wang,J., Fu,B., Yu,Y., Mao,Q., Yao,M., Yu,X. and Cai,J.<br>USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I<br>Am J Cancer Res (2025) 15, 4999-5013. PubMed  Europe PubMed DOI  PMC  EPMC  K
  9. Freimann,K., Brummer,A., Warmerdam,R., Rupall,T.S., Hernandez-Ledesma,A.L., Chiou,J., Holzinger,E.R., Maranville,J.C., Nakic,N., Ongen,H., Stefanucci,L., Turchin,M.C., Franke,L., Vosa,U., Jones,C.P., Medina-Rivera,A., Trynka,G., Kisand,K., Bergmann,S. and Alasoo,K.<br>Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus<br>Nat Commun (2025) 16, 8795-8795. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Kooij,R., Pol,V., Gan,J., van Doodewaerd,B.R., Sapmaz,A., Campos Alonso,M., Fritz,G., Knobeloch,K.P. and Geurink,P.P.<br>High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-Specific Protease mUSP18<br>Angew Chem Int Ed Engl (2025) , e202510941-e202510941. PubMed  Europe PubMed DOI  I
  11. Li,L., Liu,N., Yang,P., Rao,C., Kong,L., Huang,Y., Lei,Q. and Liu,H.<br>USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2alpha-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells<br>Sci Rep (2025) 15, 15659-15659. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Song,A., Yang,Q.C., Wang,W.D., Wang,S., Li,H., Wu,L. and Sun,Z.J.<br>Tumor-Intrinsic SIRPA Drives Pyroptosis Evasion in Head and Neck Cancer<br>J Dent Res (2025) , 220345241305590-220345241305590. PubMed  Europe PubMed DOI  K
  13. Vasou,A., Nightingale,K., Cetkovska,V., Scheler,J., Bamford,C.G.G., Andrejeva,J., Rowe,J.C., Swatek,K.N., Schwarz-Linek,U., Randall,R.E., McLauchlan,J., Weekes,M.P., Bogunovic,D. and Hughes,D.J.<br>ISG15-Dependent Stabilisation of USP18 Is Necessary but Not Sufficient to Regulate Type I Interferon Signalling in Humans<br>Eur J Immunol (2025) 55, e202451651-e202451651. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Wang,Q., Ren,S., Pan,Z., Chen,Y. and Liu,X.<br>HOXA5 Derives the Malignant Progression and Cisplatin Resistance of Esophageal Squamous Cell Carcinoma by Regulating USP18-Mediated IFI27 Deubiquitination<br>Thorac Cancer (2025) 16, e70013-e70013. PubMed  Europe PubMed DOI  PMC  EPMC  K
    15. 2024
  15. Arimoto,K.I., Zhang,Y., Matsuura,S., Miyauchi,S. and Zhang,D.E.<br>Hypersensitivity to type I interferon as a cause of hydrocephalus development<br>Brain Res (2024) 1840, 149082-149082. PubMed  Europe PubMed DOI
  16. Bonacci,T., Bolhuis,D.L., Brown,N.G. and Emanuele,M.J.<br>Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41<br>bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  17. Chen,Y., Li,R., Li,Z., Yang,B., He,J., Li,J., Li,P., Zhou,Z., Wu,Y., Zhao,Y. and Guo,G.<br>Bulk and single cells transcriptomes with experimental validation identify USP18 as a novel glioma prognosis and proliferation indicator<br>Exp Ther Med (2024) 27, 229-229. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Feng,Z., Pan,L., Qiao,C., Yang,Y., Yang,X. and Xie,Y.<br>Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18<br>Phytomedicine (2024) 134, 155970-155970. PubMed  Europe PubMed DOI
  19. Geng,L., Liu,F., Yang,L., Liu,Y. and Wu,G.<br>USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1<br>Exp Cell Res (2024) , 114284-114284. PubMed  Europe PubMed DOI  K
  20. Jin,X., Bai,Y., Xu,X., Wu,F., Long,X. and Yao,Y.<br>USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjogren syndrome<br>Immunol Res (2024) 73, 10-10. PubMed  Europe PubMed DOI  K
  21. Lai,J.H., Wu,D.W., Huang,C.Y., Hung,L.F., Wu,C.H. and Ho,L.J.<br>USP18 induction regulates immunometabolism to attenuate M1 signal-polarized macrophages and enhance IL-4-polarized macrophages in systemic lupus erythematosus<br>Clin Immunol (2024) 265, 110285-110285. PubMed  Europe PubMed DOI
  22. Mei,W., Faraj Tabrizi,S., Godina,C., Lovisa,A.F., Isaksson,K., Jernstrom,H. and Tavazoie,S.F.<br>A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor<br>Cell (2024) PubMed  Europe PubMed DOI
  23. Song,M., Yi,F., Zeng,F., Zheng,L., Huang,L., Sun,X., Huang,Q., Deng,J., Wang,H. and Gu,W.<br>USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6<br>Mol Neurobiol (2024) 61, 6658-6674. PubMed  Europe PubMed DOI
  24. Tang,N. and Liu,X.<br>USP18 promotes colon adenocarcinoma progression via targeting the ERK-MNK signaling pathway<br>J Gene Med (2024) 26, e3709-e3709. PubMed  Europe PubMed DOI  K
  25. Wang,L., Li,M., Lian,G., Yang,S., Wu,Y. and Cui,J.<br>USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D<br>Research (Wash D C) (2024) 7, 0380-0380. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Xie,Z., Huang,M., Xu,W., Liu,F. and Huang,D.<br>USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway<br>Cardiovasc Toxicol (2024) 24, 576-586. PubMed  Europe PubMed DOI
  27. Zhang,Y., Gao,J., Liu,Y., Zhong,L., He,S. and Qiu,C.<br>Deubiquitinase USP18 inhibits hepatic stellate cells activation and alleviates liver fibrosis via regulation of TAK1 activity<br>Exp Cell Res (2024) 442, 114235-114235. PubMed  Europe PubMed DOI
    28. 2023
  28. Gan,J., Pinto-Fernandez,A., Flierman,D., Akkermans,J.J.L.L., O'Brien,D.P., Greenwood,H., Scott,H.C., Fritz,G., Knobeloch,K.P., Neefjes,J., van Dam,H., Ovaa,H., Ploegh,H.L., Kessler,B.M., Geurink,P.P. and Sapmaz,A.<br>USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism<br>Proc Natl Acad Sci U S A (2023) 120, e2315163120-e2315163120. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Gonzalez-Amor,M., Dorado,B. and Andres,V.<br>Emerging roles of interferon-stimulated gene-15 in age-related telomere attrition, the DNA damage response, and cardiovascular disease<br>Front Cell Dev Biol (2023) 11, 1128594-1128594. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Lai,J.H., Wu,D.W., Wu,C.H., Hung,L.F., Huang,C.Y., Ka,S.M., Chen,A. and Ho,L.J.<br>USP18 enhances dengue virus replication by regulating mitochondrial DNA release<br>Sci Rep (2023) 13, 20126-20126. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Li,L., Yin,Y., Zhang,J., Wu,X., Liu,J., Chai,J., Yang,Y., Li,M., Jia,Q. and Liu,Y.<br>USP18 regulates the malignant phenotypes of glioblastoma stem cells<br>Pathol Res Pract (2023) 247, 154572-154572. PubMed  Europe PubMed DOI
  32. Ma,Z.R., Xiong,Q.W., Cai,S.Z., Ding,L.T., Yin,C.H., Xia,H.L., Liu,W., Dai,S., Zhang,Y., Zhu,Z.H., Huang,Z.J., Wang,Q. and Yan,X.M.<br>USP18 enhances the resistance of BRAF-mutated melanoma cells to vemurafenib by stabilizing cGAS expression to induce cell autophagy<br>Int Immunopharmacol (2023) 122, 110617-110617. PubMed  Europe PubMed DOI
  33. Olie,C.S., Pinto-Fernandez,A., Damianou,A., Vendrell,I., Mei,H., den Hamer,B., van der Wal,E., de Greef,J.C., Raz,V. and Kessler,B.M.<br>USP18 is an essential regulator of muscle cell differentiation and maturation<br>Cell Death Dis (2023) 14, 231-231. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Qi'ao,Z., Zi-Lu,W., Pei-Bo,L. and Jian-Ping,X.<br>USP18-mediated protein deISGylation and its role in tuberculosis and other infectious diseases<br>Yi Chuan (2023) 45, 998-1006. PubMed  Europe PubMed DOI  V
  35. Xie,H., Chen,J., Ma,C., Zhao,J. and Cui,M.<br>UBP43 promotes epithelial ovarian carcinogenesis via activation of beta-catenin signaling pathway<br>Cell Biol Int (2023) 47, 1427-1440. PubMed  Europe PubMed DOI  K
  36. Yuan,L., Xu,J., Qin,F., Yi,X., Zhong,Z., Gu,X. and Gong,G.<br>USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy<br>Neurosci Lett (2023) 810, 137359-137359. PubMed  Europe PubMed DOI
  37. Zhang,X., Gong,S., Li,H., Jiang,J., Jia,Y., Zhang,R., Liu,H., Wang,A., Jin,Y. and Lin,P.<br>USP18 promotes endometrial receptivity via the JAK/STAT1 and the ISGylation pathway<br>Theriogenology (2023) 202, 110-118. PubMed  Europe PubMed DOI
    38. 2022
  38. Chang,Y., Zhou,L., Zhong,X., Shi,Z., Sun,X., Wang,Y., Li,R., Long,Y., Zhou,H., Quan,C., Kermode,A.G., Yu,Q. and Qiu,W.<br>Clinical and genetic analysis of familial neuromyelitis optica spectrum disorder in Chinese: associated with ubiquitin-specific peptidase USP18 gene variants<br>J Neurol Neurosurg Psychiatry (2022) 93, 1269-1275. PubMed  Europe PubMed DOI
  39. Chen,Z., Zheng,L., Chen,Y., Liu,X., Kawakami,M., Mustachio,L.M., Roszik,J., Ferry-Galow,K.V., Parchment,R.E., Liu,X., Andresson,T., Duncan,G., Kurie,J.M., Rodriguez-Canales,J., Liu,X. and Dmitrovsky,E.<br>Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis<br>Cancer Biol Ther (2022) 23, 265-280. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Li,G., Shi,W., Xu,Y., Li,K., Chen,Z., Lv,M., Lv,J., Qiu,T., Qian,Q., Ji,J., Liu,W., Liu,B. and Zhao,Y.<br>The USP18-FBXO6 axis maintains the malignancy of ovarian cancer<br>Biochem Biophys Res Commun (2022) 593, 101-107. PubMed  Europe PubMed DOI
  41. Liu,M., Gao,S., Xu,X., Zhang,L., Xu,B. and Lu,D.<br>USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway<br>Acta Biochim Pol (2022) 69, 417-422. PubMed  Europe PubMed DOI  K
  42. Oki,N., Yamada,S., Tanaka,T., Fukui,H., Hatakeyama,S. and Okumura,F.<br>Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylation<br>Biochem Biophys Res Commun (2022) 625, 94-101. PubMed  Europe PubMed DOI  PMC  EPMC  I
  43. Tanikawa,T., Fujii,K., Sugie,Y. and Tsunekuni,R.<br>Ubiquitin-specific protease 18 in mallard (Anas platyrhynchos) interferes with type I interferon-mediated inhibition of high pathogenicity avian influenza virus replication<br>Virology (2022) 577, 32-42. PubMed  Europe PubMed DOI  K
    44. 2021
  44. Hou,J., Han,L., Zhao,Z., Liu,H., Zhang,L., Ma,C., Yi,F., Liu,B., Zheng,Y. and Gao,C.<br>USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS<br>Nat Commun (2021) 12, 2970-2970. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Hu,B., Ge,C. and Zhu,C.<br>Ubiquitin-specific peptidase 18 negatively regulates and inhibits lipopolysaccharide-induced sepsis by targeting transforming growth factor-beta-activated kinase 1 activity<br>Int Immunol (2021) 33, 461-468. PubMed  Europe PubMed DOI
  46. Jiang,Z., Shen,J., Ding,J., Yuan,Y., Gao,L., Yang,Z. and Zhao,X.<br>USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-kappaB/ROS signaling<br>Toxicol In Vitro (2021) 75, 105181-105181. PubMed  Europe PubMed DOI
  47. Liu,W., Ge,X., Zhou,Z., Jiang,D., Rong,Y., Wang,J., Ji,C., Fan,J., Yin,G. and Cai,W.<br>Deubiquitinase USP18 regulates reactive astrogliosis by stabilizing SOX9<br>Glia (2021) PubMed  Europe PubMed DOI
  48. Lu,R., Wu,G., Chen,M., Ji,D., Liu,Y., Zhou,G.G. and Fu,W.<br>USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells<br>Mol Ther Oncolytics (2021) 23, 477-487. PubMed  Europe PubMed DOI  PMC  EPMC  K
  49. Pan,A., Li,Y., Guan,J., Zhang,P., Zhang,C., Han,Y., Zhang,T., Cheng,Y., Sun,L., Lu,S., Weng,J., Ren,Q., Fan,S., Wang,W. and Wang,J.<br>USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner<br>Oncol Lett (2021) 21, 421-421. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Song,C., Peng,J., Wei,Y., Shao,J., Chen,X., Zhang,X. and Xu,J.<br>USP18 promotes tumor metastasis in esophageal squamous cell carcinomas via deubiquitinating ZEB1<br>Exp Cell Res (2021) 409, 112884-112884. PubMed  Europe PubMed DOI  K
    51. 2020
  51. Alsohime,F., Martin-Fernandez,M., Temsah,M.H., Alabdulhafid,M., Le Voyer,T., Alghamdi,M., Qiu,X., Alotaibi,N., Alkahtani,A., Buta,S., Jouanguy,E., Al-Eyadhy,A., Gruber,C., Hasan,G.M., Bashiri,F.A., Halwani,R., Hassan,H.H., Al-Muhsen,S., Alkhamis,N., Alsum,Z., Casanova,J.L., Bustamante,J., Bogunovic,D. and Alangari,A.A.<br>JAK Inhibitor therapy in a child with inherited USP18 deficiency<br>N Engl J Med (2020) 382, 256-265. PubMed  Europe PubMed DOI  M
  52. Ciccarese,F., Grassi,A., Pasqualini,L., Rosano,S., Noghero,A., Montenegro,F., Bussolino,F., Di Camillo,B., Finesso,L., Toffolo,G.M., Mitola,S. and Indraccolo,S.<br>Genetic perturbation of IFN-alpha transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis<br>Comput Struct Biotechnol J (2020) 18, 3977-3986. PubMed  Europe PubMed DOI  PMC  EPMC  K
  53. Delihas,N.<br>Genesis of Non-Coding RNA Genes in Human Chromosome 22-A Sequence Connection with Protein Genes Separated by Evolutionary Time<br>Noncoding RNA (2020) 6 PubMed  Europe PubMed DOI  PMC  EPMC
  54. Diao,W., Guo,Q., Zhu,C., Song,Y., Feng,H., Cao,Y., Du,M. and Chen,H.<br>USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway<br>BMC Cancer (2020) 20, 741-741. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Feng,L., Wang,K., Tang,P., Chen,S., Liu,T., Lei,J., Yuan,R., Hu,Z., Li,W. and Yu,X.<br>Deubiquitinase USP18 promotes the progression of pancreatic cancer via enhancing the Notch1-c-Myc axis<br>Aging (Albany NY) (2020) 12, 19273-19292. PubMed  Europe PubMed DOI
  56. Huang,F., Zheng,C., Huang,L., Lin,C. and Wang,J.<br>USP18 directly regulates Snail1 protein through ubiquitination pathway in colorectal cancer<br>Cancer Cell Int (2020) 20, 346-346. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Kang,J.A. and Jeon,Y.J.<br>Emerging Roles of USP18: From Biology to Pathophysiology<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  58. Kespohl,M., Bredow,C., Klingel,K., Voss,M., Paeschke,A., Zickler,M., Poller,W., Kaya,Z., Eckstein,J., Fechner,H., Spranger,J., Fahling,M., Wirth,E.K., Radoshevich,L., Thery,F., Impens,F., Berndt,N., Knobeloch,K.P. and Beling,A.<br>Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming<br>Sci Adv (2020) 6, eaay1109-eaay1109. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Li,Y., Yao,M., Duan,X., Ye,H., Li,S., Chen,L., Yang,C. and Chen,Y.<br>The USP18 cysteine protease promotes HBV production independent of its protease activity<br>Virol J (2020) 17, 47-47. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Liu,X., Lu,Y., Chen,Z., Liu,X., Hu,W., Zheng,L., Chen,Y., Kurie,J.M., Shi,M., Mustachio,L.M., Andresson,T., Fox,S., Roszik,J., Kawakami,M., Freemantle,S. and Dmitrovsky,E.<br>The Ubiquitin Specific Protease USP18 Promotes Lipolysis, Fatty Acid Oxidation and Lung Cancer Growth<br>Mol Cancer Res (2020) PubMed  Europe PubMed DOI
  61. Pinto-Fernandez,A., Salio,M., Partridge,T., Chen,J., Vere,G., Greenwood,H., Olie,C.S., Damianou,A., Scott,H.C., Pegg,H.J., Chiarenza,A., Diaz-Saez,L., Smith,P., Gonzalez-Lopez,C., Patel,B., Anderton,E., Jones,N., Hammonds,T.R., Huber,K., Muschel,R., Borrow,P., Cerundolo,V. and Kessler,B.M.<br>Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity<br>Br J Cancer (2020) PubMed  Europe PubMed DOI
  62. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.<br>Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  63. Rubino,E., Cruciani,M., Tchitchek,N., Le Tortorec,A., Rolland,A.D., Veli,O., Vallet,L., Gaggi,G., Michel,F., Dejucq-Rainsford,N. and Pellegrini,S.<br>Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21<br>Front Genet (2020) 11, 627007-627007. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Wang,B., Li,Y., Wang,H., Zhao,J., Zhao,Y., Liu,Z. and Ma,H.<br>FOXO3a is stabilized by USP18-mediated de-ISGylation and inhibits TGF-beta1-induced fibronectin expression<br>J Investig Med (2020) 68, 786-791. PubMed  Europe PubMed DOI
    65. 2019
  65. Dziamalek-Macioszczyk,P., Harazna,J. and Stompor,T.<br>Versatility of USP18 in physiology and pathophysiology<br>Acta Biochim Pol (2019) 66, 389-392. PubMed  Europe PubMed DOI
  66. Jimenez Fernandez,D., Hess,S. and Knobeloch,K.P.<br>Strategies to target ISG15 and USP18 toward therapeutic applications<br>Front Chem (2019) 7, 923-923. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Li,Y., Ma,M.X., Qin,B., Lin,L.T., Richardson,C.D., Feld,J., McGilvray,I.D. and Chen,L.<br>The ubiquitin-specific protease 18 promotes hepatitis C virus production by increasing viral infectivity<br>Mediators Inflamm (2019) 2019, 3124745-3124745. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Osei Kuffour,E., Konig,R., Haussinger,D., Schulz,W.A. and Munk,C.<br>ISG15 Deficiency enhances HIV-1 infection by accumulating misfolded p53<br>MBio (2019) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  69. Xiang,J., Zhang,X., Fu,J., Wang,H. and Zhao,Y.<br>USP18 Overexpression protects against focal cerebral ischemia injury in mice by suppressing microglial activation<br>Neuroscience (2019) 419, 121-128. PubMed  Europe PubMed DOI
    70. 2018
  70. Basters,A., Knobeloch,K.P. and Fritz,G.<br>How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease<br>FEBS J (2018) 285, 1024-1029. PubMed  Europe PubMed DOI  P
  71. Basters,A., Knobeloch,K.P. and Fritz,G.<br>USP18 - a multifunctional component in the Interferon response<br>Biosci Rep (2018) 38, BSR20180250-BSR20180250. PubMed  Europe PubMed DOI
  72. Mustachio,L.M., Lu,Y., Kawakami,M., Roszik,J., Freemantle,S.J., Liu,X. and Dmitrovsky,E.<br>Evidence for the ISG15-specific deubiquitinase USP18 as an antineoplastic target<br>Cancer Res (2018) 78, 587-592. PubMed  Europe PubMed DOI
  73. Tan,Y., Zhou,G., Wang,X., Chen,W. and Gao,H.<br>USP18 promotes breast cancer growth by upregulating EGFR and activating the AKT/Skp2 pathway<br>Int J Oncol (2018) 53, 371-383. PubMed  Europe PubMed DOI
    74. 2017
  74. Basters,A., Geurink,P.P., Rocker,A., Witting,K.F., Tadayon,R., Hess,S., Semrau,M.S., Storici,P., Ovaa,H., Knobeloch,K.P. and Fritz,G.<br>Structural basis of the specificity of USP18 toward ISG15<br>Nat Struct Mol Biol (2017) 24, 270-278. PubMed  Europe PubMed DOI
  75. Jiao,B., Shi,X., Chen,Y., Ye,H., Yao,M., Hong,W., Li,S., Duan,X., Li,Y., Wang,Y. and Chen,L.<br>Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway<br>Oncotarget (2017) 8, 105923-105935. PubMed  Europe PubMed DOI  PMC  EPMC
  76. Mustachio,L.M., Kawakami,M., Lu,Y., Rodriguez-Canales,J., Mino,B., Behrens,C., Wistuba,I., Bota-Rabassedas,N., Yu,J., Lee,J.J., Roszik,J., Zheng,L., Liu,X., Freemantle,S.J. and Dmitrovsky,E.<br>The ISG15-specific protease USP18 regulates stability of PTEN<br>Oncotarget (2017) 8, 3-14. PubMed  Europe PubMed DOI
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