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Literature for peptidase C19.030: ubiquitin-specific peptidase 18

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: T Target, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. An,Y., Guo,C., Wang,X., Liu,J., Li,Z., Ding,J., Zhang,Q., Zhou,H., Xia,B., Wang,J., Yu,Y., Wan,C., Wang,J. and Dai,J.
    USP18 Promotes Cholesterol Efflux and Mitigates Atherosclerosis by Deubiquitinating ABCG1
    J Cell Mol Med (2025) 29, e70320-e70320. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Bonacci,T., Bolhuis,D.L., Brown,N.G. and Emanuele,M.J.
    Mechanisms of USP18 specificity towards ISG15 revealed by paralog sequence analysis comparison
    J Biol Chem (2025) , 110288-110288. PubMed  Europe PubMed DOI
  3. Carey,M.M., O'Donovan,T.R., Coveney,C.M. and McKenna,S.L.
    Inhibition of USP18 in the presence of IFN-alpha elevates apoptosis, autophagy, and chemosensitivity of oesophageal cancer cell lines
    Exp Cell Res (2025) 452, 114768-114768. PubMed  Europe PubMed DOI  K
  4. Chai,L., Sun,Y., Wang,Y. and Zhao,C.
    USP18 Confers Paclitaxel Resistance in Non-Small Cell Lung Cancer by Stabilizing SHANK1 Expression Via Deubiquitination
    J Biochem Mol Toxicol (2025) 39, e70197-e70197. PubMed  Europe PubMed DOI
  5. Cheng,Y., Liu,G., Yu,L., Li,H., Liu,Y., Yang,H. and Zhang,P.
    A related mechanism for USP18 regulating diabetic cardiomyopathy procession: promoting activity of AKT signaling pathway by improving Notch1 stability
    Biochem Biophys Res Commun (2025) 784, 152626-152626. PubMed  Europe PubMed DOI
  6. Davis,G.J., Omole,A.O., Jung,Y., Rut,W., Holewinski,R., Suazo,K.F., Kim,H.R., Yang,M., Andresson,T., Drag,M. and Yoo,E.
    Chemical tools to define and manipulate interferon-inducible Ubl protease USP18
    Nat Commun. (2025) 16(1):957, 957-957. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Davis,G.J., Omole,A.O., Jung,Y., Rut,W., Holewinski,R., Suazo,K.F., Kim,H.R., Yang,M., Andresson,T., Drag,M. and Yoo,E.
    Chemical tools to define and manipulate interferon-inducible Ubl protease USP18
    Nat Commun (2025) 16, 957-957. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Fang,Y., Wang,J., Fu,B., Yu,Y., Mao,Q., Yao,M., Yu,X. and Cai,J.
    USP18 promote tumor immune evasion in pancreatic cancer through enhancing autolysosome-mediated degradation of MHC-I
    Am J Cancer Res (2025) 15, 4999-5013. PubMed  Europe PubMed DOI  PMC  EPMC  K
  9. Freimann,K., Brummer,A., Warmerdam,R., Rupall,T.S., Hernandez-Ledesma,A.L., Chiou,J., Holzinger,E.R., Maranville,J.C., Nakic,N., Ongen,H., Stefanucci,L., Turchin,M.C., Franke,L., Vosa,U., Jones,C.P., Medina-Rivera,A., Trynka,G., Kisand,K., Bergmann,S. and Alasoo,K.
    Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus
    Nat Commun (2025) 16, 8795-8795. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Kooij,R., Pol,V., Gan,J., van Doodewaerd,B.R., Sapmaz,A., Campos Alonso,M., Fritz,G., Knobeloch,K.P. and Geurink,P.P.
    High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-Specific Protease mUSP18
    Angew Chem Int Ed Engl (2025) , e202510941-e202510941. PubMed  Europe PubMed DOI  I
  11. Li,L., Liu,N., Yang,P., Rao,C., Kong,L., Huang,Y., Lei,Q. and Liu,H.
    USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2alpha-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells
    Sci Rep (2025) 15, 15659-15659. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Song,A., Yang,Q.C., Wang,W.D., Wang,S., Li,H., Wu,L. and Sun,Z.J.
    Tumor-Intrinsic SIRPA Drives Pyroptosis Evasion in Head and Neck Cancer
    J Dent Res (2025) , 220345241305590-220345241305590. PubMed  Europe PubMed DOI  K
  13. Vasou,A., Nightingale,K., Cetkovska,V., Scheler,J., Bamford,C.G.G., Andrejeva,J., Rowe,J.C., Swatek,K.N., Schwarz-Linek,U., Randall,R.E., McLauchlan,J., Weekes,M.P., Bogunovic,D. and Hughes,D.J.
    ISG15-Dependent Stabilisation of USP18 Is Necessary but Not Sufficient to Regulate Type I Interferon Signalling in Humans
    Eur J Immunol (2025) 55, e202451651-e202451651. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Wang,Q., Ren,S., Pan,Z., Chen,Y. and Liu,X.
    HOXA5 Derives the Malignant Progression and Cisplatin Resistance of Esophageal Squamous Cell Carcinoma by Regulating USP18-Mediated IFI27 Deubiquitination
    Thorac Cancer (2025) 16, e70013-e70013. PubMed  Europe PubMed DOI  PMC  EPMC  K
    15. 2024
  15. Arimoto,K.I., Zhang,Y., Matsuura,S., Miyauchi,S. and Zhang,D.E.
    Hypersensitivity to type I interferon as a cause of hydrocephalus development
    Brain Res (2024) 1840, 149082-149082. PubMed  Europe PubMed DOI
  16. Bonacci,T., Bolhuis,D.L., Brown,N.G. and Emanuele,M.J.
    Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  17. Chen,Y., Li,R., Li,Z., Yang,B., He,J., Li,J., Li,P., Zhou,Z., Wu,Y., Zhao,Y. and Guo,G.
    Bulk and single cells transcriptomes with experimental validation identify USP18 as a novel glioma prognosis and proliferation indicator
    Exp Ther Med (2024) 27, 229-229. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Feng,Z., Pan,L., Qiao,C., Yang,Y., Yang,X. and Xie,Y.
    Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18
    Phytomedicine (2024) 134, 155970-155970. PubMed  Europe PubMed DOI
  19. Geng,L., Liu,F., Yang,L., Liu,Y. and Wu,G.
    USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1
    Exp Cell Res (2024) , 114284-114284. PubMed  Europe PubMed DOI  K
  20. Jin,X., Bai,Y., Xu,X., Wu,F., Long,X. and Yao,Y.
    USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjogren syndrome
    Immunol Res (2024) 73, 10-10. PubMed  Europe PubMed DOI  K
  21. Lai,J.H., Wu,D.W., Huang,C.Y., Hung,L.F., Wu,C.H. and Ho,L.J.
    USP18 induction regulates immunometabolism to attenuate M1 signal-polarized macrophages and enhance IL-4-polarized macrophages in systemic lupus erythematosus
    Clin Immunol (2024) 265, 110285-110285. PubMed  Europe PubMed DOI
  22. Mei,W., Faraj Tabrizi,S., Godina,C., Lovisa,A.F., Isaksson,K., Jernstrom,H. and Tavazoie,S.F.
    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
    Cell (2024) PubMed  Europe PubMed DOI
  23. Song,M., Yi,F., Zeng,F., Zheng,L., Huang,L., Sun,X., Huang,Q., Deng,J., Wang,H. and Gu,W.
    USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6
    Mol Neurobiol (2024) 61, 6658-6674. PubMed  Europe PubMed DOI
  24. Tang,N. and Liu,X.
    USP18 promotes colon adenocarcinoma progression via targeting the ERK-MNK signaling pathway
    J Gene Med (2024) 26, e3709-e3709. PubMed  Europe PubMed DOI  K
  25. Wang,L., Li,M., Lian,G., Yang,S., Wu,Y. and Cui,J.
    USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D
    Research (Wash D C) (2024) 7, 0380-0380. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Xie,Z., Huang,M., Xu,W., Liu,F. and Huang,D.
    USP18 Curbs the Progression of Metabolic Hypertension by Suppressing JAK/STAT Pathway
    Cardiovasc Toxicol (2024) 24, 576-586. PubMed  Europe PubMed DOI
  27. Zhang,Y., Gao,J., Liu,Y., Zhong,L., He,S. and Qiu,C.
    Deubiquitinase USP18 inhibits hepatic stellate cells activation and alleviates liver fibrosis via regulation of TAK1 activity
    Exp Cell Res (2024) 442, 114235-114235. PubMed  Europe PubMed DOI
    28. 2023
  28. Gan,J., Pinto-Fernandez,A., Flierman,D., Akkermans,J.J.L.L., O'Brien,D.P., Greenwood,H., Scott,H.C., Fritz,G., Knobeloch,K.P., Neefjes,J., van Dam,H., Ovaa,H., Ploegh,H.L., Kessler,B.M., Geurink,P.P. and Sapmaz,A.
    USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism
    Proc Natl Acad Sci U S A (2023) 120, e2315163120-e2315163120. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Gonzalez-Amor,M., Dorado,B. and Andres,V.
    Emerging roles of interferon-stimulated gene-15 in age-related telomere attrition, the DNA damage response, and cardiovascular disease
    Front Cell Dev Biol (2023) 11, 1128594-1128594. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Lai,J.H., Wu,D.W., Wu,C.H., Hung,L.F., Huang,C.Y., Ka,S.M., Chen,A. and Ho,L.J.
    USP18 enhances dengue virus replication by regulating mitochondrial DNA release
    Sci Rep (2023) 13, 20126-20126. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Li,L., Yin,Y., Zhang,J., Wu,X., Liu,J., Chai,J., Yang,Y., Li,M., Jia,Q. and Liu,Y.
    USP18 regulates the malignant phenotypes of glioblastoma stem cells
    Pathol Res Pract (2023) 247, 154572-154572. PubMed  Europe PubMed DOI
  32. Ma,Z.R., Xiong,Q.W., Cai,S.Z., Ding,L.T., Yin,C.H., Xia,H.L., Liu,W., Dai,S., Zhang,Y., Zhu,Z.H., Huang,Z.J., Wang,Q. and Yan,X.M.
    USP18 enhances the resistance of BRAF-mutated melanoma cells to vemurafenib by stabilizing cGAS expression to induce cell autophagy
    Int Immunopharmacol (2023) 122, 110617-110617. PubMed  Europe PubMed DOI
  33. Olie,C.S., Pinto-Fernandez,A., Damianou,A., Vendrell,I., Mei,H., den Hamer,B., van der Wal,E., de Greef,J.C., Raz,V. and Kessler,B.M.
    USP18 is an essential regulator of muscle cell differentiation and maturation
    Cell Death Dis (2023) 14, 231-231. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Qi'ao,Z., Zi-Lu,W., Pei-Bo,L. and Jian-Ping,X.
    USP18-mediated protein deISGylation and its role in tuberculosis and other infectious diseases
    Yi Chuan (2023) 45, 998-1006. PubMed  Europe PubMed DOI  V
  35. Xie,H., Chen,J., Ma,C., Zhao,J. and Cui,M.
    UBP43 promotes epithelial ovarian carcinogenesis via activation of beta-catenin signaling pathway
    Cell Biol Int (2023) 47, 1427-1440. PubMed  Europe PubMed DOI  K
  36. Yuan,L., Xu,J., Qin,F., Yi,X., Zhong,Z., Gu,X. and Gong,G.
    USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy
    Neurosci Lett (2023) 810, 137359-137359. PubMed  Europe PubMed DOI
  37. Zhang,X., Gong,S., Li,H., Jiang,J., Jia,Y., Zhang,R., Liu,H., Wang,A., Jin,Y. and Lin,P.
    USP18 promotes endometrial receptivity via the JAK/STAT1 and the ISGylation pathway
    Theriogenology (2023) 202, 110-118. PubMed  Europe PubMed DOI
    38. 2022
  38. Chang,Y., Zhou,L., Zhong,X., Shi,Z., Sun,X., Wang,Y., Li,R., Long,Y., Zhou,H., Quan,C., Kermode,A.G., Yu,Q. and Qiu,W.
    Clinical and genetic analysis of familial neuromyelitis optica spectrum disorder in Chinese: associated with ubiquitin-specific peptidase USP18 gene variants
    J Neurol Neurosurg Psychiatry (2022) 93, 1269-1275. PubMed  Europe PubMed DOI
  39. Chen,Z., Zheng,L., Chen,Y., Liu,X., Kawakami,M., Mustachio,L.M., Roszik,J., Ferry-Galow,K.V., Parchment,R.E., Liu,X., Andresson,T., Duncan,G., Kurie,J.M., Rodriguez-Canales,J., Liu,X. and Dmitrovsky,E.
    Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis
    Cancer Biol Ther (2022) 23, 265-280. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Li,G., Shi,W., Xu,Y., Li,K., Chen,Z., Lv,M., Lv,J., Qiu,T., Qian,Q., Ji,J., Liu,W., Liu,B. and Zhao,Y.
    The USP18-FBXO6 axis maintains the malignancy of ovarian cancer
    Biochem Biophys Res Commun (2022) 593, 101-107. PubMed  Europe PubMed DOI
  41. Liu,M., Gao,S., Xu,X., Zhang,L., Xu,B. and Lu,D.
    USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway
    Acta Biochim Pol (2022) 69, 417-422. PubMed  Europe PubMed DOI  K
  42. Oki,N., Yamada,S., Tanaka,T., Fukui,H., Hatakeyama,S. and Okumura,F.
    Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylation
    Biochem Biophys Res Commun (2022) 625, 94-101. PubMed  Europe PubMed DOI  PMC  EPMC  I
  43. Tanikawa,T., Fujii,K., Sugie,Y. and Tsunekuni,R.
    Ubiquitin-specific protease 18 in mallard (Anas platyrhynchos) interferes with type I interferon-mediated inhibition of high pathogenicity avian influenza virus replication
    Virology (2022) 577, 32-42. PubMed  Europe PubMed DOI  K
    44. 2021
  44. Hou,J., Han,L., Zhao,Z., Liu,H., Zhang,L., Ma,C., Yi,F., Liu,B., Zheng,Y. and Gao,C.
    USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
    Nat Commun (2021) 12, 2970-2970. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Hu,B., Ge,C. and Zhu,C.
    Ubiquitin-specific peptidase 18 negatively regulates and inhibits lipopolysaccharide-induced sepsis by targeting transforming growth factor-beta-activated kinase 1 activity
    Int Immunol (2021) 33, 461-468. PubMed  Europe PubMed DOI
  46. Jiang,Z., Shen,J., Ding,J., Yuan,Y., Gao,L., Yang,Z. and Zhao,X.
    USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-kappaB/ROS signaling
    Toxicol In Vitro (2021) 75, 105181-105181. PubMed  Europe PubMed DOI
  47. Liu,W., Ge,X., Zhou,Z., Jiang,D., Rong,Y., Wang,J., Ji,C., Fan,J., Yin,G. and Cai,W.
    Deubiquitinase USP18 regulates reactive astrogliosis by stabilizing SOX9
    Glia (2021) PubMed  Europe PubMed DOI
  48. Lu,R., Wu,G., Chen,M., Ji,D., Liu,Y., Zhou,G.G. and Fu,W.
    USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells
    Mol Ther Oncolytics (2021) 23, 477-487. PubMed  Europe PubMed DOI  PMC  EPMC  K
  49. Pan,A., Li,Y., Guan,J., Zhang,P., Zhang,C., Han,Y., Zhang,T., Cheng,Y., Sun,L., Lu,S., Weng,J., Ren,Q., Fan,S., Wang,W. and Wang,J.
    USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner
    Oncol Lett (2021) 21, 421-421. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Song,C., Peng,J., Wei,Y., Shao,J., Chen,X., Zhang,X. and Xu,J.
    USP18 promotes tumor metastasis in esophageal squamous cell carcinomas via deubiquitinating ZEB1
    Exp Cell Res (2021) 409, 112884-112884. PubMed  Europe PubMed DOI  K
    51. 2020
  51. Alsohime,F., Martin-Fernandez,M., Temsah,M.H., Alabdulhafid,M., Le Voyer,T., Alghamdi,M., Qiu,X., Alotaibi,N., Alkahtani,A., Buta,S., Jouanguy,E., Al-Eyadhy,A., Gruber,C., Hasan,G.M., Bashiri,F.A., Halwani,R., Hassan,H.H., Al-Muhsen,S., Alkhamis,N., Alsum,Z., Casanova,J.L., Bustamante,J., Bogunovic,D. and Alangari,A.A.
    JAK Inhibitor therapy in a child with inherited USP18 deficiency
    N Engl J Med (2020) 382, 256-265. PubMed  Europe PubMed DOI  M
  52. Ciccarese,F., Grassi,A., Pasqualini,L., Rosano,S., Noghero,A., Montenegro,F., Bussolino,F., Di Camillo,B., Finesso,L., Toffolo,G.M., Mitola,S. and Indraccolo,S.
    Genetic perturbation of IFN-alpha transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis
    Comput Struct Biotechnol J (2020) 18, 3977-3986. PubMed  Europe PubMed DOI  PMC  EPMC  K
  53. Delihas,N.
    Genesis of Non-Coding RNA Genes in Human Chromosome 22-A Sequence Connection with Protein Genes Separated by Evolutionary Time
    Noncoding RNA (2020) 6 PubMed  Europe PubMed DOI  PMC  EPMC
  54. Diao,W., Guo,Q., Zhu,C., Song,Y., Feng,H., Cao,Y., Du,M. and Chen,H.
    USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway
    BMC Cancer (2020) 20, 741-741. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Feng,L., Wang,K., Tang,P., Chen,S., Liu,T., Lei,J., Yuan,R., Hu,Z., Li,W. and Yu,X.
    Deubiquitinase USP18 promotes the progression of pancreatic cancer via enhancing the Notch1-c-Myc axis
    Aging (Albany NY) (2020) 12, 19273-19292. PubMed  Europe PubMed DOI
  56. Huang,F., Zheng,C., Huang,L., Lin,C. and Wang,J.
    USP18 directly regulates Snail1 protein through ubiquitination pathway in colorectal cancer
    Cancer Cell Int (2020) 20, 346-346. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Kang,J.A. and Jeon,Y.J.
    Emerging Roles of USP18: From Biology to Pathophysiology
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  58. Kespohl,M., Bredow,C., Klingel,K., Voss,M., Paeschke,A., Zickler,M., Poller,W., Kaya,Z., Eckstein,J., Fechner,H., Spranger,J., Fahling,M., Wirth,E.K., Radoshevich,L., Thery,F., Impens,F., Berndt,N., Knobeloch,K.P. and Beling,A.
    Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming
    Sci Adv (2020) 6, eaay1109-eaay1109. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Li,Y., Yao,M., Duan,X., Ye,H., Li,S., Chen,L., Yang,C. and Chen,Y.
    The USP18 cysteine protease promotes HBV production independent of its protease activity
    Virol J (2020) 17, 47-47. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Liu,X., Lu,Y., Chen,Z., Liu,X., Hu,W., Zheng,L., Chen,Y., Kurie,J.M., Shi,M., Mustachio,L.M., Andresson,T., Fox,S., Roszik,J., Kawakami,M., Freemantle,S. and Dmitrovsky,E.
    The Ubiquitin Specific Protease USP18 Promotes Lipolysis, Fatty Acid Oxidation and Lung Cancer Growth
    Mol Cancer Res (2020) PubMed  Europe PubMed DOI
  61. Pinto-Fernandez,A., Salio,M., Partridge,T., Chen,J., Vere,G., Greenwood,H., Olie,C.S., Damianou,A., Scott,H.C., Pegg,H.J., Chiarenza,A., Diaz-Saez,L., Smith,P., Gonzalez-Lopez,C., Patel,B., Anderton,E., Jones,N., Hammonds,T.R., Huber,K., Muschel,R., Borrow,P., Cerundolo,V. and Kessler,B.M.
    Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity
    Br J Cancer (2020) PubMed  Europe PubMed DOI
  62. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  63. Rubino,E., Cruciani,M., Tchitchek,N., Le Tortorec,A., Rolland,A.D., Veli,O., Vallet,L., Gaggi,G., Michel,F., Dejucq-Rainsford,N. and Pellegrini,S.
    Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21
    Front Genet (2020) 11, 627007-627007. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Wang,B., Li,Y., Wang,H., Zhao,J., Zhao,Y., Liu,Z. and Ma,H.
    FOXO3a is stabilized by USP18-mediated de-ISGylation and inhibits TGF-beta1-induced fibronectin expression
    J Investig Med (2020) 68, 786-791. PubMed  Europe PubMed DOI
    65. 2019
  65. Dziamalek-Macioszczyk,P., Harazna,J. and Stompor,T.
    Versatility of USP18 in physiology and pathophysiology
    Acta Biochim Pol (2019) 66, 389-392. PubMed  Europe PubMed DOI
  66. Jimenez Fernandez,D., Hess,S. and Knobeloch,K.P.
    Strategies to target ISG15 and USP18 toward therapeutic applications
    Front Chem (2019) 7, 923-923. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Li,Y., Ma,M.X., Qin,B., Lin,L.T., Richardson,C.D., Feld,J., McGilvray,I.D. and Chen,L.
    The ubiquitin-specific protease 18 promotes hepatitis C virus production by increasing viral infectivity
    Mediators Inflamm (2019) 2019, 3124745-3124745. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Osei Kuffour,E., Konig,R., Haussinger,D., Schulz,W.A. and Munk,C.
    ISG15 Deficiency enhances HIV-1 infection by accumulating misfolded p53
    MBio (2019) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  69. Xiang,J., Zhang,X., Fu,J., Wang,H. and Zhao,Y.
    USP18 Overexpression protects against focal cerebral ischemia injury in mice by suppressing microglial activation
    Neuroscience (2019) 419, 121-128. PubMed  Europe PubMed DOI
    70. 2018
  70. Basters,A., Knobeloch,K.P. and Fritz,G.
    How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease
    FEBS J (2018) 285, 1024-1029. PubMed  Europe PubMed DOI  P
  71. Basters,A., Knobeloch,K.P. and Fritz,G.
    USP18 - a multifunctional component in the Interferon response
    Biosci Rep (2018) 38, BSR20180250-BSR20180250. PubMed  Europe PubMed DOI
  72. Mustachio,L.M., Lu,Y., Kawakami,M., Roszik,J., Freemantle,S.J., Liu,X. and Dmitrovsky,E.
    Evidence for the ISG15-specific deubiquitinase USP18 as an antineoplastic target
    Cancer Res (2018) 78, 587-592. PubMed  Europe PubMed DOI
  73. Tan,Y., Zhou,G., Wang,X., Chen,W. and Gao,H.
    USP18 promotes breast cancer growth by upregulating EGFR and activating the AKT/Skp2 pathway
    Int J Oncol (2018) 53, 371-383. PubMed  Europe PubMed DOI
    74. 2017
  74. Basters,A., Geurink,P.P., Rocker,A., Witting,K.F., Tadayon,R., Hess,S., Semrau,M.S., Storici,P., Ovaa,H., Knobeloch,K.P. and Fritz,G.
    Structural basis of the specificity of USP18 toward ISG15
    Nat Struct Mol Biol (2017) 24, 270-278. PubMed  Europe PubMed DOI
  75. Jiao,B., Shi,X., Chen,Y., Ye,H., Yao,M., Hong,W., Li,S., Duan,X., Li,Y., Wang,Y. and Chen,L.
    Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway
    Oncotarget (2017) 8, 105923-105935. PubMed  Europe PubMed DOI  PMC  EPMC
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