$VAR1 = undef;

Summary for peptidase C19.030: ubiquitin-specific peptidase 18

Names
MEROPS Name	ubiquitin-specific peptidase 18
Other names	ISG15-specific peptidase, interferon-stimulated gene factor 15-specific peptidase, ubiquitin-specific protease 18, UBP43 ubiquitin-specific protease (Mus musculus), USP18

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C19 >> Subfamily (none) >> C19.030
Holotype	ubiquitin-specific peptidase 18 (Homo sapiens), Uniprot accession Q9UMW8 (peptidase unit: 17-372), MERNUM MER0005641
History	Identifier created: MEROPS 3.4 (5 November 1999)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity	It is reported that ubiquitin-specific peptidase 18 (as UBP43) efficiently hydrolyses only ISG15 fusion proteins, including native ISG15 conjugates linked via isopeptide bonds (<%Malakhov %etal, 2002[20040908A033]%>).
Activity status	human: putative mouse: putative
Knockout	The phenotype of ubiquitin-specific peptidase 18 knockout mice includes shortened life span, hypersensitivity to interferon and neuronal damage (Tokarz et al., 2004). However, the phenotypic alterations of the knockout mice are not caused by lack of ISG15 deconjugation as at one time proposed (Knobeloch et al., 2005).
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR44658:SF1