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Literature for peptidase C19.017: ubiquitin-specific peptidase 9X

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,Y., Jia,H., Zhang,X., Zhao,H., Xiao,Y., Li,N., Yao,Y. and Xing,X.
    Disruption of GPSM1/CSF1 signaling reprograms tumor-associated macrophages to overcome anti-PD-1 resistance in colorectal cancer
    J Immunother Cancer13, PubMed  Europe PubMed DOI
  2. Kim,G.W., Cha,M., Ong,H.T.M., Yoo,J., Jeon,Y.H., Lee,S.W., Oh,S.Y., Kang,M.J., Kim,Y. and Kwon,S.H.
    HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
    Adv Sci (Weinh)e2501553-e2501553. PubMed  Europe PubMed DOI
  3. Koo,H., Park,K.C., Sohn,H.A., Kang,M., Kim,D.J., Park,Z.Y., Park,S., Min,S.H., Park,S.H., You,Y.M., Han,Y., Kim,B.K., Lee,C.H., Kim,Y.S., Chung,S.J., Yeom,Y.I. and Lee,D.C.
    Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development
    Nat Commun16, 628-628. PubMed  Europe PubMed DOI
  4. Lei,Y., Hu,J., Zhao,J., Liu,Q., Zhang,S.W., Wu,F., Liu,Y., Ren,H., Qin,X., Wu,X., Gao,F., Hu,J., Ouyang,K., Liu,Q., Zheng,X., Shi,L. and Wang,X.
    Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance
    Dev Cell PubMed  Europe PubMed DOI
  5. Mu,B., Jing,J., Li,R. and Li,C.
    USP9X deubiquitinates TRRAP to promote glioblastoma cell proliferation and migration and M2 macrophage polarization
    Naunyn Schmiedebergs Arch Pharmacol398, 855-865. PubMed  Europe PubMed DOI
  6. Oak,S., Karajgikar,O., Gadewal,N., Sulkshane,P., Verma,T., Gupta,S. and Teni,T.
    The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting
    FEBS J PubMed  Europe PubMed DOI  I
  7. Shao,N., Cai,K., Hong,Y., Wu,L. and Luo,Q.
    USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro
    Ren Fail47, 2458761-2458761. PubMed  Europe PubMed DOI
  8. Tao,J., Wang,Z., Shi,R., Lin,L., Li,M., Meng,Y., Luo,S., Jiang,X., Guo,Z., Shang,Y. and Lu,Z.
    ERK-USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth
    Nat Struct Mol Biol PubMed  Europe PubMed DOI
  9. Xie,C., Zhang,H.L., Yuan,J., Zhang,Y., Liu,Y.C., Xu,Q. and Chen,L.R.
    Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4(+) T Cells
    Clin Exp Pharmacol Physiol52, e70018-e70018. PubMed  Europe PubMed DOI
  10. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
    Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
    World J Surg Oncol23, 60-60. PubMed  Europe PubMed DOI  V
  11. Yang,J., Yao,Y., Fan,S. and Li,X.
    USP9X PROMOTES LPS-INDUCED FIBROBLAST CELL APOPTOSIS, INFLAMMATION, AND OXIDATIVE STRESS BY REGULATION OF TBL1XR1 DEUBIQUITINATION
    Shock63, 210-216. PubMed  Europe PubMed DOI  K
  12. Zhang,Z., Yu,X., Wen,L., Wang,J., Li,Z., Zhang,Y., Cheng,J., Kan,R., Zhang,W., Shen,Y., Yuan,S. and Zhao,L.
    USP9X integrates TGF-beta and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2alpha-maintained stemness
    Cell Death Dis16, 312-312. PubMed  Europe PubMed DOI
    13. 2024
  13. Becirovic,T., Zhang,B., Lindskog,C., Norberg,E., Vakifahmetoglu-Norberg,H., Kaminskyy,V.O. and Kochetkova,E.
    Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer
    Cell Death Discov10, 342-342. PubMed  Europe PubMed DOI  K
  14. Chen,W., Shan,Y., Wang,M., Liang,R. and Sa,R.
    Chicoric acid exerts therapeutic effects in DSS-induced ulcerative colitis by targeting the USP9X/IGF2BP2 axis
    Br J Pharmacol PubMed  Europe PubMed DOI
  15. Chen,Y., Feng,X., Wu,Z., Yang,Y., Rao,X., Meng,R., Zhang,S., Dong,X., Xu,S., Wu,G. and Jie,X.
    USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine gamma-lyase
    J Biomed Sci31, 55-55. PubMed  Europe PubMed DOI  K
  16. Feng,Q., Liu,Q., Liu,Z., Xu,J., Yang,Y., Zhu,Y., Lu,G., Xu,G., Wu,D., Wang,F., Liu,B., Wang,W. and Ding,X.
    USP9X inhibits metastasis in pulmonary sarcomatoid carcinoma by regulating epithelial-mesenchymal transition, angiogenesis and immune infiltration
    Transl Oncol47, 101950-101950. PubMed  Europe PubMed DOI
  17. Feng,Y., Li,Y., Ma,F., Wu,E., Cheng,Z., Zhou,S., Wang,Z., Yang,L., Sun,X. and Zhang,J.
    Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8(+) T cell proportion in tumor-bearing mice through the USP9X signaling pathway
    Chin J Nat Med22, 329-340. PubMed  Europe PubMed DOI
  18. Gao,H., Chen,Z., Zhao,L., Ji,C. and Xing,F.
    Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatment
    Biochim Biophys Acta Rev Cancer1879, 189099-189099. PubMed  Europe PubMed DOI  V
  19. Gong,S., Xiong,H., Lei,Y., Huang,S., Ouyang,Y., Cao,C. and Wang,Y.
    Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-kappab pathway
    Ren Fail46, 2361089-2361089. PubMed  Europe PubMed DOI
  20. Ho,H.H. and Wing,S.S.
    alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies
    Front Mol Neurosci17, 1498459-1498459. PubMed  Europe PubMed DOI  V
  21. Lin,L., Yuan,Q., Gu,J., Bai,G., Cong,X., Hu,Q., Hou,J., Jin,X., Liu,X., Huang,B., Zhang,Y. and Lu,J.
    CARM1-mediated OGT arginine methylation promotes non-small cell lung cancer glycolysis by stabilizing OGT
    Cell Death Dis15, 927-927. PubMed  Europe PubMed DOI
  22. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans52, 1085-1098. PubMed  Europe PubMed DOI  V
  23. Paul,S., Chatterjee,A., Das,K., Ray,A., Basu,A., Mukhopadhyay,S. and Sen,P.
    Thrombin confers chemotherapeutic resistance by promoting transcriptional induction and post-translational stabilization of pro-survival MCL1 in TNBC
    J Biol Chem108025-108025. PubMed  Europe PubMed DOI
  24. Riley,A.K., Grant,M., Snell,A., Cromwell,E., Vichas,A., Moorthi,S., Rominger,C., Modukuri,S.P., Urisman,A., Castel,P., Wan,L. and Berger,A.H.
    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
    iScience27, 110499-110499. PubMed  Europe PubMed DOI
  25. Wang,Y., Wang,C., Yang,F., Chen,Y., Shi,Y., Xu,R., Zhang,Z. and Yan,Y.
    USP9X-enriched MSC-sEV inhibits LSEC angiogenesis in MASH mice by downregulating the IkappaBalpha/NF-kappaB/Ang-2 pathway
    Pharmacol Res209, 107471-107471. PubMed  Europe PubMed DOI
  26. Xiong,S., Liu,F., Sun,J., Gao,S., Wong,C.C.L., Tu,P. and Wang,Y.
    Abrogation of USP9X is a potential strategy to decrease PEG10 levels and impede tumor progression in cutaneous T-cell lymphoma
    J Invest Dermatol144, 2778-2788. PubMed  Europe PubMed DOI
  27. Xu,L., Xiong,L., Chen,Y., Chen,J., Liu,X., Xu,Y., Shen,Y., Wang,S., Yu,S. and Xu,X.
    IGFALS suppresses hepatocellular carcinoma progression by stabilizing PPAR-gamma
    Int Immunopharmacol143, 113414-113414. PubMed  Europe PubMed DOI
  28. Xu,W., Zhang,Y., Su,Y., Li,L., Yang,X., Wang,L. and Gao,H.
    USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1
    BMC Gastroenterol24, 239-239. PubMed  Europe PubMed DOI  K
  29. Zheng,S., Zhu,J., Wang,C., Wu,Y., Sun,S., Guo,H., Chang,Y., Ma,R. and Li,G.
    USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice
    Cell Commun Signal22, 516-516. PubMed  Europe PubMed DOI
    30. 2023
  30. Cao,R., Zhu,R., Sha,Z., Qi,S., Zhong,Z., Zheng,F., Lei,Y., Tan,Y., Zhu,Y., Wang,Y., Wang,Y. and Yu,F.X.
    WWC1/2 regulate spinogenesis and cognition in mice by stabilizing AMOT
    Cell Death Dis14, 491-491. PubMed  Europe PubMed DOI
  31. Chappell,D.L., Sandhu,P.K., Wong,J.P., Bhatt,A.P., Liu,X., Buhrlage,S.J., Temple,B.R.S., Major,M.B. and Damania,B.
    KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle
    J Virol97, e0176322-e0176322. PubMed  Europe PubMed DOI  K
  32. Hogh-Binder,S.A., Klein,D., Wolfsperger,F., Huber,S.M., Hennenlotter,J., Stenzl,A. and Rudner,J.
    Protein Levels of Anti-Apoptotic Mcl-1 and the Deubiquitinase USP9x Are Cooperatively Upregulated during Prostate Cancer Progression and Limit Response of Prostate Cancer Cells to Radiotherapy
    Cancers (Basel)15, PubMed  Europe PubMed DOI  K
  33. Liao,L., Zhang,Y.L., Deng,L., Chen,C., Ma,X.Y., Andriani,L., Yang,S.Y., Hu,S.Y., Zhang,F.L., Shao,Z.M. and Li,D.Q.
    Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer
    Cancer Res83, 471-484. PubMed  Europe PubMed DOI
  34. Meng,Y., Hong,C., Yang,S., Qin,Z., Yang,L. and Huang,Y.
    Roles of USP9X in cellular functions and tumorigenesis (Review)
    Oncol Lett26, 506-506. PubMed  Europe PubMed DOI  V
  35. Perurena,N., Lock,R., Davis,R.A., Raghavan,S., Pilla,N.F., Ng,R., Loi,P., Guild,C.J., Miller,A.L., Sicinska,E., Cleary,J.M., Rubinson,D.A., Wolpin,B.M., Gray,N.S., Santagata,S., Hahn,W.C., Morton,J.P., Sansom,O.J., Aguirre,A.J. and Cichowski,K.
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
    Cell Rep Med4, 101007-101007. PubMed  Europe PubMed DOI
  36. Riley,A.K., Grant,M., Snell,A., Vichas,A., Moorthi,S., Urisman,A., Castel,P., Wan,L. and Berger,A.H.
    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
    bioRxiv PubMed  Europe PubMed DOI
  37. Song,N., Deng,L., Zeng,L., He,L., Liu,C., Liu,L. and Fu,R.
    USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle
    Mol Carcinog62, 1487-1503. PubMed  Europe PubMed DOI  I
  38. Wang,P., Wang,J., Yao,S., Cui,M., Cheng,Y., Liu,W., Gao,Z., Hu,J., Zhang,J. and Zhang,H.
    Deubiquitinase USP9X stabilizes RNA m(6)A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival
    J Biol Chem299, 105055-105055. PubMed  Europe PubMed DOI  K
  39. Wang,S., Huo,X., Yang,Y., Mo,Y., Kollipara,R.K. and Kittler,R.
    Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma
    Cancer Lett552, 215984-215984. PubMed  Europe PubMed DOI  I
  40. Xiang,Y., Li,X., Cai,M. and Cai,D.
    USP9X promotes lipopolysaccharide-stimulated acute lung injury by deubiquitination of NLRP3
    Cell Biol Int47, 394-405. PubMed  Europe PubMed DOI
    41. 2022
  41. Guan,T., Yang,X., Liang,H., Chen,J., Chen,Y., Zhu,Y. and Liu,T.
    Deubiquitinating enzyme USP9X regulates metastasis and chemoresistance in triple-negative breast cancer by stabilizing Snail1
    J Cell Physiol237, 2992-3000. PubMed  Europe PubMed DOI
  42. Sheng,L., Chen,J., Tong,Y., Zhang,Y., Feng,Q. and Tang,Z.
    USP9x promotes CD8 (+) T-cell dysfunction in association with autophagy inhibition in septic liver injury
    Acta Biochim Biophys Sin (Shanghai)54, 1-10. PubMed  Europe PubMed DOI  I
  43. Wang,B., Tang,X., Yao,L., Wang,Y., Chen,Z., Li,M., Wu,N., Wu,D., Dai,X., Jiang,H. and Ai,D.
    Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis
    J Clin Invest132, PubMed  Europe PubMed DOI
    44. 2021
  44. Barban do Patrocinio,A., Cabral,F.J., de Paiva,T.H., Magalhaes,L.G., Paula,L.A.L., Brigato,O.M., Guerra-Sa,R. and Rodrigues,V.
    Deubiquitinating enzymes as possible drug targets for schistosomiasis
    Acta Trop217, 105856-105856. PubMed  Europe PubMed DOI  I
  45. Chen,W., Song,J., Liu,S., Tang,B., Shen,L., Zhu,J., Fang,S., Wu,F., Zheng,L., Qiu,R., Chen,C., Gao,Y., Tu,J., Zhao,Z. and Ji,J.
    USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bbeta via deubiquitinating EGLN3
    J Biomed Sci28, 44-44. PubMed  Europe PubMed DOI  K
  46. Jaiswal,A., Murakami,K., Elia,A., Shibahara,Y., Done,S.J., Wood,S.A., Donato,N.J., Ohashi,P.S. and Reedijk,M.
    Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI  K
  47. Jie,X., Fong,W.P., Zhou,R., Zhao,Y., Zhao,Y., Meng,R., Zhang,S., Dong,X., Zhang,T., Yang,K., Wu,G. and Xu,S.
    USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-beta2 transcription
    Cell Death Differ PubMed  Europe PubMed DOI
  48. Macrae,T.A. and Ramalho-Santos,M.
    The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
    Nat Commun12, 1865-1865. PubMed  Europe PubMed DOI
  49. Shimizu,K., Gi,M., Suzuki,S., North,B.J., Watahiki,A., Fukumoto,S., Asara,J.M., Tokunaga,F., Wei,W. and Inuzuka,H.
    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
    Cell Rep37, 109988-109988. PubMed  Europe PubMed DOI
  50. Sulkshane,P., Pawar,S.N., Waghole,R., Pawar,S.S., Rajput,P., Uthale,A., Oak,S., Kalkar,P., Wani,H., Patil,R., Nair,S., Rane,P. and Teni,T.
    Elevated USP9X drives early-to-late-stage oral tumorigenesis via stabilisation of anti-apoptotic MCL-1 protein and impacts outcome in oral cancers
    Br J Cancer PubMed  Europe PubMed DOI
  51. Sun,X.H., Xiao,H.M., Zhang,M., Lin,Z.Y., Yang,Y., Chen,R., Liu,P.Q., Huang,K.P. and Huang,H.Q.
    USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells
    Biochem Pharmacol188, 114562-114562. PubMed  Europe PubMed DOI
    52. 2020
  52. Cheasley,D., Nigam,A., Zethoven,M., Hunter,S., Etemadmoghadam,D., Semple,T., Allan,P., Carey,M.S., Fernandez,M.L., Dawson,A., Kobel,M., Huntsman,D.G., Page,C.L., Mes-Masson,A.M., Provencher,D., Hacker,N., Gao,Y., Bowtell,D., de Fazio,A., Gorringe,K.L. and Campbell,I.G.
    Genomic analysis of low-grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities
    J Pathol PubMed  Europe PubMed DOI
  53. Downey,A., Olcott,M., Spector,D., Bird,K., Ter Doest,A., Pierce,Z., Quach,E., Sparks,S., Super,C., Naifeh,J., Powers,A., White,M. and Hensley,K.
    Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes
    Free Radic Biol Med161, 115-124. PubMed  Europe PubMed DOI
  54. Jia,J., Bissa,B., Brecht,L., Allers,L., Choi,S.W., Gu,Y., Zbinden,M., Burge,M.R., Timmins,G., Hallows,K., Behrends,C. and Deretic,V.
    AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system
    Autophagy16, 1550-1552. PubMed  Europe PubMed DOI
  55. Shahriyar,S.A., Seo,S.U., Min,K.J., Kubatka,P., Min,D.S., Chang,J.S., Kim,D.E., Woo,S.M. and Kwon,T.K.
    Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
    Cancers (Basel)12, PubMed  Europe PubMed DOI
  56. Song,X., Yang,W., Wu,C., Han,Y. and Lu,Y.
    USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling
    Oncol Lett20, 2897-2905. PubMed  Europe PubMed DOI  K
  57. Wrobel,L., Siddiqi,F.H., Hill,S.M., Son,S.M., Karabiyik,C., Kim,H. and Rubinsztein,D.C.
    mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR
    Cell Rep33, 108564-108564. PubMed  Europe PubMed DOI
    58. 2019
  58. Akiyama,H., Umezawa,Y., Ishida,S., Okada,K., Nogami,A. and Miura,O.
    Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress
    Cancer Lett453, 84-94. PubMed  Europe PubMed DOI  I
  59. Lu,Q., Zhang,F.L., Lu,D.Y., Shao,Z.M. and Li,D.Q.
    USP9X stabilizes BRCA1 and confers resistance to DNA-damaging agents in human cancer cells
    Cancer Med8, 6730-6740. PubMed  Europe PubMed DOI  M  I
  60. Paudel,P., Zhang,Q., Leung,C., Greenberg,H.C., Guo,Y., Chern,Y.H., Dong,A., Li,Y., Vedadi,M., Zhuang,Z. and Tong,Y.
    Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X
    Proc Natl Acad Sci U S A116, 7288-7297. PubMed  Europe PubMed DOI  P  S
  61. Zhang,J., Wang,J., Luan,T., Zuo,Y., Chen,J., Zhang,H., Ye,Z., Wang,H. and Hai,B.
    Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics
    Oncol Rep41, 3292-3304. PubMed  Europe PubMed DOI
    62. 2018
  62. Chen,X., Yu,C., Gao,J., Zhu,H., Cui,B., Zhang,T., Zhou,Y., Liu,Q., He,H., Xiao,R., Huang,R., Xie,H., Gao,D. and Zhou,H.
    A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer
    Theranostics8, 2348-2360. PubMed  Europe PubMed DOI
  63. Han,K.J., Wu,Z., Pearson,C.G., Peng,J., Song,K. and Liu,C.W.
    Deubiquitinase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein
    J Cell Sci132, jcs221663-jcs221663. PubMed  Europe PubMed DOI
  64. Li,Z., Cheng,Z., Raghothama,C., Cui,Z., Liu,K., Li,X., Jiang,C., Jiang,W., Tan,M., Ni,X., Pandey,A., Liu,J.O. and Dang,Y.
    USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1
    Nucleic Acids Res46, 823-839. PubMed  Europe PubMed DOI
  65. Ma,T., Chen,W., Zhi,X., Liu,H., Zhou,Y., Chen,B.W., Hu,L., Shen,J., Zheng,X., Zhang,S., Zhang,B., Li,H. and Liang,T.
    USP9X inhibition improves gemcitabine sensitivity in pancreatic cancer by inhibiting autophagy
    Cancer Lett436, 129-138. PubMed  Europe PubMed DOI  I
  66. Miotto,B., Marchal,C., Adelmant,G., Guinot,N., Xie,P., Marto,J.A., Zhang,L. and Defossez,P.A.
    Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells
    Nucleic Acids Res46, 4392-4404. PubMed  Europe PubMed DOI
  67. Zhang,Y., Duan,C., Yang,J., Chen,S., Liu,Q., Zhou,L., Huang,Z., Xu,Y. and Xu,G.
    Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1
    Biochem J475, 1507-1522. PubMed  Europe PubMed DOI
  68. Zhu,C., Ji,X., Zhang,H., Zhou,Q., Cao,X., Tang,M., Si,Y., Yan,H., Li,L., Liang,T., Feng,X.H. and Zhao,B.
    Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway
    J Biol Chem293, 1178-1191. PubMed  Europe PubMed DOI
    69. 2017
  69. Au,P.Y.B., Huang,L., Broley,S., Gallagher,L., Creede,E., Lahey,D., Ordorica,S., Mina,K., Boycott,K.M., Baynam,G. and Dyment,D.A.
    Two females with mutations in USP9X highlight the variable expressivity of the intellectual disability syndrome
    Eur J Med Genet60, 359-364. PubMed  Europe PubMed DOI  M
  70. Bridges,C.R., Tan,M.C., Premarathne,S., Nanayakkara,D., Bellette,B., Zencak,D., Domingo,D., Gecz,J., Murtaza,M., Jolly,L.A. and Wood,S.A.
    USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors
    Sci Rep7, 391-391. PubMed  Europe PubMed DOI
  71. Kishi,K., Uchida,A., Takase,H.M., Suzuki,H., Kurohmaru,M., Tsunekawa,N., Kanai-Azuma,M., Wood,S.A. and Kanai,Y.
    Spermatogonial deubiquitinase USP9X is essential for proper spermatogenesis in mice
    Reproduction154, 135-143. PubMed  Europe PubMed DOI
  72. Wang,Q., Tang,Y., Xu,Y., Xu,S., Jiang,Y., Dong,Q., Zhou,Y. and Ge,W.
    The X-linked deubiquitinase USP9X is an integral component of centrosome
    J Biol Chem292, 12874-12884. PubMed  Europe PubMed DOI
    73. 2016
  73. Karpel-Massler,G., Banu,M.A., Shu,C., Halatsch,M.E., Westhoff,M.A., Bruce,J.N., Canoll,P. and Siegelin,M.D.
    Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo
    Oncotarget7, 12791-12805. PubMed  Europe PubMed DOI  I
  74. Kim,M., Kim,M., Park,S.J., Lee,C. and Lim,D.S.
    Role of angiomotin-like 2 mono-ubiquitination on YAP inhibition
    EMBO Rep17, 64-78. PubMed  Europe PubMed DOI
  75. Naik,E. and Dixit,V.M.
    Usp9X is required for lymphocyte activation and homeostasis through its control of ZAP70 ubiquitination and PKCbeta kinase activity
    J Immunol196, 3438-3451. PubMed  Europe PubMed DOI
  76. Reijnders,M.R., Zachariadis,V., Latour,B., Jolly,L., Mancini,G.M., Pfundt,R., Wu,K.M., van Ravenswaaij-Arts,C.M., Veenstra-Knol,H.E., Anderlid,B.M., Wood,S.A., Cheung,S.W., Barnicoat,A., Probst,F., Magoulas,P., Brooks,A.S., Malmgren,H., Harila-Saari,A., Marcelis,C.M., Vreeburg,M., Hobson,E., Sutton,V.R., Stark,Z., Vogt,J., Cooper,N., Lim,J.Y., Price,S., Lai,A.H., Domingo,D., Reversade,B., Gecz,J., Gilissen,C., Brunner,H.G., Kini,U., Roepman,R., Nordgren,A. and Kleefstra,T.
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