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Literature for peptidase C19.017: ubiquitin-specific peptidase 9X

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Biber,P., Carminati,A., Mohager,W., Ohanna,M., Girard,C.A., Lecacheur,M., Kahil,M., Bouvet,O., Irondelle,M., Audebert,S., Khaled,M., Tartare-Deckert,S. and Deckert,M.
    USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization
    Cell Rep (2025) 44, 116372-116372. PubMed  Europe PubMed DOI  K
  2. Chen,Y., Jia,H., Zhang,X., Zhao,H., Xiao,Y., Li,N., Yao,Y. and Xing,X.
    Disruption of GPSM1/CSF1 signaling reprograms tumor-associated macrophages to overcome anti-PD-1 resistance in colorectal cancer
    J Immunother Cancer (2025) 13 PubMed  Europe PubMed DOI
  3. Chen,Y., Wang,W., Cui,C., Zhang,Y., Li,Z., Yin,H. and Han,S.
    USP9X-triggered ferroptosis mediates follicular atresia via deubiquitinating Beclin1 in chicken
    J Anim Sci Biotechnol (2025) 16, 134-134. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Kim,G.W., Cha,M., Ong,H.T.M., Yoo,J., Jeon,Y.H., Lee,S.W., Oh,S.Y., Kang,M.J., Kim,Y. and Kwon,S.H.
    HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis
    Adv Sci (Weinh) (2025) , e2501553-e2501553. PubMed  Europe PubMed DOI
  5. Koo,H., Park,K.C., Sohn,H.A., Kang,M., Kim,D.J., Park,Z.Y., Park,S., Min,S.H., Park,S.H., You,Y.M., Han,Y., Kim,B.K., Lee,C.H., Kim,Y.S., Chung,S.J., Yeom,Y.I. and Lee,D.C.
    Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development
    Nat Commun (2025) 16, 628-628. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Lei,Y., Hu,J., Zhao,J., Liu,Q., Zhang,S.W., Wu,F., Liu,Y., Ren,H., Qin,X., Wu,X., Gao,F., Hu,J., Ouyang,K., Liu,Q., Zheng,X., Shi,L. and Wang,X.
    Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance
    Dev Cell (2025) PubMed  Europe PubMed DOI
  7. Mu,B., Jing,J., Li,R. and Li,C.
    USP9X deubiquitinates TRRAP to promote glioblastoma cell proliferation and migration and M2 macrophage polarization
    Naunyn Schmiedebergs Arch Pharmacol (2025) 398, 855-865. PubMed  Europe PubMed DOI
  8. Oak,S., Karajgikar,O., Gadewal,N., Sulkshane,P., Verma,T., Gupta,S. and Teni,T.
    The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting
    FEBS J (2025) PubMed  Europe PubMed DOI  I
  9. Shao,N., Cai,K., Hong,Y., Wu,L. and Luo,Q.
    USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro
    Ren Fail (2025) 47, 2458761-2458761. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Song,S.R., Woo,S.M., Seo,S.U., Jeong,Y.J., Chae,J., Hur,G.M. and Kwon,T.K.
    Zerumbone enhances TRAIL-induced apoptosis via USP9x-mediated downregulation of Mcl-1
    Biochem Biophys Res Commun (2025) 775, 152194-152194. PubMed  Europe PubMed DOI
  11. Tao,J., Wang,Z., Shi,R., Lin,L., Li,M., Meng,Y., Luo,S., Jiang,X., Guo,Z., Shang,Y. and Lu,Z.
    ERK-USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth
    Nat Struct Mol Biol (2025) PubMed  Europe PubMed DOI
  12. Xie,C., Zhang,H.L., Yuan,J., Zhang,Y., Liu,Y.C., Xu,Q. and Chen,L.R.
    Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4(+) T Cells
    Clin Exp Pharmacol Physiol (2025) 52, e70018-e70018. PubMed  Europe PubMed DOI
  13. Yan,Z., Siyi,W., Siyu,W., YuanYuan,T. and Jiajia,L.
    USP9X promotes acute myeloid leukemia progression and adriamycin resistance by regulating METTL7A deubiquitination
    Cell Signal (2025) 139, 112314-112314. PubMed  Europe PubMed DOI  K
  14. Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
    Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
    World J Surg Oncol (2025) 23, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC  V
  15. Yang,J., Yao,Y., Fan,S. and Li,X.
    USP9X PROMOTES LPS-INDUCED FIBROBLAST CELL APOPTOSIS, INFLAMMATION, AND OXIDATIVE STRESS BY REGULATION OF TBL1XR1 DEUBIQUITINATION
    Shock (2025) 63, 210-216. PubMed  Europe PubMed DOI  K
  16. Zhang,Z., Yu,X., Wen,L., Wang,J., Li,Z., Zhang,Y., Cheng,J., Kan,R., Zhang,W., Shen,Y., Yuan,S. and Zhao,L.
    USP9X integrates TGF-beta and hypoxia signalings to promote ovarian cancer chemoresistance via HIF-2alpha-maintained stemness
    Cell Death Dis (2025) 16, 312-312. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2024
  17. Becirovic,T., Zhang,B., Lindskog,C., Norberg,E., Vakifahmetoglu-Norberg,H., Kaminskyy,V.O. and Kochetkova,E.
    Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer
    Cell Death Discov (2024) 10, 342-342. PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Chen,W., Shan,Y., Wang,M., Liang,R. and Sa,R.
    Chicoric acid exerts therapeutic effects in DSS-induced ulcerative colitis by targeting the USP9X/IGF2BP2 axis
    Br J Pharmacol (2024) PubMed  Europe PubMed DOI
  19. Chen,Y., Feng,X., Wu,Z., Yang,Y., Rao,X., Meng,R., Zhang,S., Dong,X., Xu,S., Wu,G. and Jie,X.
    USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine gamma-lyase
    J Biomed Sci (2024) 31, 55-55. PubMed  Europe PubMed DOI  PMC  EPMC  K
  20. Feng,Q., Liu,Q., Liu,Z., Xu,J., Yang,Y., Zhu,Y., Lu,G., Xu,G., Wu,D., Wang,F., Liu,B., Wang,W. and Ding,X.
    USP9X inhibits metastasis in pulmonary sarcomatoid carcinoma by regulating epithelial-mesenchymal transition, angiogenesis and immune infiltration
    Transl Oncol (2024) 47, 101950-101950. PubMed  Europe PubMed DOI
  21. Feng,Y., Li,Y., Ma,F., Wu,E., Cheng,Z., Zhou,S., Wang,Z., Yang,L., Sun,X. and Zhang,J.
    Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8(+) T cell proportion in tumor-bearing mice through the USP9X signaling pathway
    Chin J Nat Med (2024) 22, 329-340. PubMed  Europe PubMed DOI
  22. Gao,H., Chen,Z., Zhao,L., Ji,C. and Xing,F.
    Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatment
    Biochim Biophys Acta Rev Cancer (2024) 1879, 189099-189099. PubMed  Europe PubMed DOI  V
  23. Gong,S., Xiong,H., Lei,Y., Huang,S., Ouyang,Y., Cao,C. and Wang,Y.
    Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-kappab pathway
    Ren Fail (2024) 46, 2361089-2361089. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Ho,H.H. and Wing,S.S.
    alpha-Synuclein ubiquitination - functions in proteostasis and development of Lewy bodies
    Front Mol Neurosci (2024) 17, 1498459-1498459. PubMed  Europe PubMed DOI  PMC  EPMC  V
  25. Lin,L., Yuan,Q., Gu,J., Bai,G., Cong,X., Hu,Q., Hou,J., Jin,X., Liu,X., Huang,B., Zhang,Y. and Lu,J.
    CARM1-mediated OGT arginine methylation promotes non-small cell lung cancer glycolysis by stabilizing OGT
    Cell Death Dis (2024) 15, 927-927. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans (2024) 52, 1085-1098. PubMed  Europe PubMed DOI  V
  27. Paul,S., Chatterjee,A., Das,K., Ray,A., Basu,A., Mukhopadhyay,S. and Sen,P.
    Thrombin confers chemotherapeutic resistance by promoting transcriptional induction and post-translational stabilization of pro-survival MCL1 in TNBC
    J Biol Chem (2024) , 108025-108025. PubMed  Europe PubMed DOI
  28. Riley,A.K., Grant,M., Snell,A., Cromwell,E., Vichas,A., Moorthi,S., Rominger,C., Modukuri,S.P., Urisman,A., Castel,P., Wan,L. and Berger,A.H.
    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
    iScience (2024) 27, 110499-110499. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Wang,Y., Wang,C., Yang,F., Chen,Y., Shi,Y., Xu,R., Zhang,Z. and Yan,Y.
    USP9X-enriched MSC-sEV inhibits LSEC angiogenesis in MASH mice by downregulating the IkappaBalpha/NF-kappaB/Ang-2 pathway
    Pharmacol Res (2024) 209, 107471-107471. PubMed  Europe PubMed DOI
  30. Xiong,S., Liu,F., Sun,J., Gao,S., Wong,C.C.L., Tu,P. and Wang,Y.
    Abrogation of USP9X is a potential strategy to decrease PEG10 levels and impede tumor progression in cutaneous T-cell lymphoma
    J Invest Dermatol (2024) 144, 2778-2788. PubMed  Europe PubMed DOI
  31. Xu,L., Xiong,L., Chen,Y., Chen,J., Liu,X., Xu,Y., Shen,Y., Wang,S., Yu,S. and Xu,X.
    IGFALS suppresses hepatocellular carcinoma progression by stabilizing PPAR-gamma
    Int Immunopharmacol (2024) 143, 113414-113414. PubMed  Europe PubMed DOI
  32. Xu,W., Zhang,Y., Su,Y., Li,L., Yang,X., Wang,L. and Gao,H.
    USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1
    BMC Gastroenterol (2024) 24, 239-239. PubMed  Europe PubMed DOI  PMC  EPMC  K
  33. Zheng,S., Zhu,J., Wang,C., Wu,Y., Sun,S., Guo,H., Chang,Y., Ma,R. and Li,G.
    USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice
    Cell Commun Signal (2024) 22, 516-516. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2023
  34. Cao,R., Zhu,R., Sha,Z., Qi,S., Zhong,Z., Zheng,F., Lei,Y., Tan,Y., Zhu,Y., Wang,Y., Wang,Y. and Yu,F.X.
    WWC1/2 regulate spinogenesis and cognition in mice by stabilizing AMOT
    Cell Death Dis (2023) 14, 491-491. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Chappell,D.L., Sandhu,P.K., Wong,J.P., Bhatt,A.P., Liu,X., Buhrlage,S.J., Temple,B.R.S., Major,M.B. and Damania,B.
    KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle
    J Virol (2023) 97, e0176322-e0176322. PubMed  Europe PubMed DOI  PMC  EPMC  K
  36. Hogh-Binder,S.A., Klein,D., Wolfsperger,F., Huber,S.M., Hennenlotter,J., Stenzl,A. and Rudner,J.
    Protein Levels of Anti-Apoptotic Mcl-1 and the Deubiquitinase USP9x Are Cooperatively Upregulated during Prostate Cancer Progression and Limit Response of Prostate Cancer Cells to Radiotherapy
    Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC  K
  37. Liao,L., Zhang,Y.L., Deng,L., Chen,C., Ma,X.Y., Andriani,L., Yang,S.Y., Hu,S.Y., Zhang,F.L., Shao,Z.M. and Li,D.Q.
    Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer
    Cancer Res (2023) 83, 471-484. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Meng,Y., Hong,C., Yang,S., Qin,Z., Yang,L. and Huang,Y.
    Roles of USP9X in cellular functions and tumorigenesis (Review)
    Oncol Lett (2023) 26, 506-506. PubMed  Europe PubMed DOI  PMC  EPMC  V
  39. Perurena,N., Lock,R., Davis,R.A., Raghavan,S., Pilla,N.F., Ng,R., Loi,P., Guild,C.J., Miller,A.L., Sicinska,E., Cleary,J.M., Rubinson,D.A., Wolpin,B.M., Gray,N.S., Santagata,S., Hahn,W.C., Morton,J.P., Sansom,O.J., Aguirre,A.J. and Cichowski,K.
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
    Cell Rep Med (2023) 4, 101007-101007. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Riley,A.K., Grant,M., Snell,A., Vichas,A., Moorthi,S., Urisman,A., Castel,P., Wan,L. and Berger,A.H.
    The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes
    bioRxiv (2023) PubMed  Europe PubMed DOI  PMC  EPMC
  41. Saha,S., Huang,S.N., Yang,X., Saha,L.K., Sun,Y., Khandagale,P., Jenkins,L.M. and Pommier,Y.
    The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes
    Nat Commun (2023) 14, 7524-7524. PubMed  Europe PubMed DOI  PMC  EPMC  K
  42. Song,N., Deng,L., Zeng,L., He,L., Liu,C., Liu,L. and Fu,R.
    USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle
    Mol Carcinog (2023) 62, 1487-1503. PubMed  Europe PubMed DOI  I
  43. Wang,P., Wang,J., Yao,S., Cui,M., Cheng,Y., Liu,W., Gao,Z., Hu,J., Zhang,J. and Zhang,H.
    Deubiquitinase USP9X stabilizes RNA m(6)A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival
    J Biol Chem (2023) 299, 105055-105055. PubMed  Europe PubMed DOI  PMC  EPMC  K
  44. Wang,S., Huo,X., Yang,Y., Mo,Y., Kollipara,R.K. and Kittler,R.
    Ablation of EWS-FLI1 by USP9X inhibition suppresses cancer cell growth in Ewing sarcoma
    Cancer Lett (2023) 552, 215984-215984. PubMed  Europe PubMed DOI  I
  45. Xiang,Y., Li,X., Cai,M. and Cai,D.
    USP9X promotes lipopolysaccharide-stimulated acute lung injury by deubiquitination of NLRP3
    Cell Biol Int (2023) 47, 394-405. PubMed  Europe PubMed DOI
    46. 2022
  46. Guan,T., Yang,X., Liang,H., Chen,J., Chen,Y., Zhu,Y. and Liu,T.
    Deubiquitinating enzyme USP9X regulates metastasis and chemoresistance in triple-negative breast cancer by stabilizing Snail1
    J Cell Physiol (2022) 237, 2992-3000. PubMed  Europe PubMed DOI
  47. Sheng,L., Chen,J., Tong,Y., Zhang,Y., Feng,Q. and Tang,Z.
    USP9x promotes CD8 (+) T-cell dysfunction in association with autophagy inhibition in septic liver injury
    Acta Biochim Biophys Sin (Shanghai) (2022) 54, 1-10. PubMed  Europe PubMed DOI  I
  48. Wang,B., Tang,X., Yao,L., Wang,Y., Chen,Z., Li,M., Wu,N., Wu,D., Dai,X., Jiang,H. and Ai,D.
    Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis
    J Clin Invest (2022) 132 PubMed  Europe PubMed DOI  PMC  EPMC
    49. 2021
  49. Barban do Patrocinio,A., Cabral,F.J., de Paiva,T.H., Magalhaes,L.G., Paula,L.A.L., Brigato,O.M., Guerra-Sa,R. and Rodrigues,V.
    Deubiquitinating enzymes as possible drug targets for schistosomiasis
    Acta Trop (2021) 217, 105856-105856. PubMed  Europe PubMed DOI  I
  50. Chen,W., Song,J., Liu,S., Tang,B., Shen,L., Zhu,J., Fang,S., Wu,F., Zheng,L., Qiu,R., Chen,C., Gao,Y., Tu,J., Zhao,Z. and Ji,J.
    USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bbeta via deubiquitinating EGLN3
    J Biomed Sci (2021) 28, 44-44. PubMed  Europe PubMed DOI  PMC  EPMC  K
  51. Jaiswal,A., Murakami,K., Elia,A., Shibahara,Y., Done,S.J., Wood,S.A., Donato,N.J., Ohashi,P.S. and Reedijk,M.
    Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer
    Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI  K
  52. Jie,X., Fong,W.P., Zhou,R., Zhao,Y., Zhao,Y., Meng,R., Zhang,S., Dong,X., Zhang,T., Yang,K., Wu,G. and Xu,S.
    USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-beta2 transcription
    Cell Death Differ (2021) PubMed  Europe PubMed DOI
  53. Macrae,T.A. and Ramalho-Santos,M.
    The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
    Nat Commun (2021) 12, 1865-1865. PubMed  Europe PubMed DOI  PMC  EPMC
  54. Shimizu,K., Gi,M., Suzuki,S., North,B.J., Watahiki,A., Fukumoto,S., Asara,J.M., Tokunaga,F., Wei,W. and Inuzuka,H.
    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
    Cell Rep (2021) 37, 109988-109988. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Sulkshane,P., Pawar,S.N., Waghole,R., Pawar,S.S., Rajput,P., Uthale,A., Oak,S., Kalkar,P., Wani,H., Patil,R., Nair,S., Rane,P. and Teni,T.
    Elevated USP9X drives early-to-late-stage oral tumorigenesis via stabilisation of anti-apoptotic MCL-1 protein and impacts outcome in oral cancers
    Br J Cancer (2021) PubMed  Europe PubMed DOI
  56. Sun,X.H., Xiao,H.M., Zhang,M., Lin,Z.Y., Yang,Y., Chen,R., Liu,P.Q., Huang,K.P. and Huang,H.Q.
    USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells
    Biochem Pharmacol (2021) 188, 114562-114562. PubMed  Europe PubMed DOI
    57. 2020
  57. Cheasley,D., Nigam,A., Zethoven,M., Hunter,S., Etemadmoghadam,D., Semple,T., Allan,P., Carey,M.S., Fernandez,M.L., Dawson,A., Kobel,M., Huntsman,D.G., Page,C.L., Mes-Masson,A.M., Provencher,D., Hacker,N., Gao,Y., Bowtell,D., de Fazio,A., Gorringe,K.L. and Campbell,I.G.
    Genomic analysis of low-grade serous ovarian carcinoma to identify key drivers and therapeutic vulnerabilities
    J Pathol (2020) PubMed  Europe PubMed DOI
  58. Downey,A., Olcott,M., Spector,D., Bird,K., Ter Doest,A., Pierce,Z., Quach,E., Sparks,S., Super,C., Naifeh,J., Powers,A., White,M. and Hensley,K.
    Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes
    Free Radic Biol Med (2020) 161, 115-124. PubMed  Europe PubMed DOI
  59. Jia,J., Bissa,B., Brecht,L., Allers,L., Choi,S.W., Gu,Y., Zbinden,M., Burge,M.R., Timmins,G., Hallows,K., Behrends,C. and Deretic,V.
    AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system
    Autophagy (2020) 16, 1550-1552. PubMed  Europe PubMed DOI
  60. Shahriyar,S.A., Seo,S.U., Min,K.J., Kubatka,P., Min,D.S., Chang,J.S., Kim,D.E., Woo,S.M. and Kwon,T.K.
    Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  61. Song,X., Yang,W., Wu,C., Han,Y. and Lu,Y.
    USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling
    Oncol Lett (2020) 20, 2897-2905. PubMed  Europe PubMed DOI  PMC  EPMC  K
  62. Wrobel,L., Siddiqi,F.H., Hill,S.M., Son,S.M., Karabiyik,C., Kim,H. and Rubinsztein,D.C.
    mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR
    Cell Rep (2020) 33, 108564-108564. PubMed  Europe PubMed DOI
    63. 2019
  63. Akiyama,H., Umezawa,Y., Ishida,S., Okada,K., Nogami,A. and Miura,O.
    Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress
    Cancer Lett (2019) 453, 84-94. PubMed  Europe PubMed DOI  I
  64. Lu,Q., Zhang,F.L., Lu,D.Y., Shao,Z.M. and Li,D.Q.
    USP9X stabilizes BRCA1 and confers resistance to DNA-damaging agents in human cancer cells
    Cancer Med (2019) 8, 6730-6740. PubMed  Europe PubMed DOI  M  I
  65. Paudel,P., Zhang,Q., Leung,C., Greenberg,H.C., Guo,Y., Chern,Y.H., Dong,A., Li,Y., Vedadi,M., Zhuang,Z. and Tong,Y.
    Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X
    Proc Natl Acad Sci U S A (2019) 116, 7288-7297. PubMed  Europe PubMed DOI  P  S
  66. Zhang,J., Wang,J., Luan,T., Zuo,Y., Chen,J., Zhang,H., Ye,Z., Wang,H. and Hai,B.
    Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics
    Oncol Rep (2019) 41, 3292-3304. PubMed  Europe PubMed DOI
    67. 2018
  67. Chen,X., Yu,C., Gao,J., Zhu,H., Cui,B., Zhang,T., Zhou,Y., Liu,Q., He,H., Xiao,R., Huang,R., Xie,H., Gao,D. and Zhou,H.
    A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer
    Theranostics (2018) 8, 2348-2360. PubMed  Europe PubMed DOI  PMC  EPMC
  68. Han,K.J., Wu,Z., Pearson,C.G., Peng,J., Song,K. and Liu,C.W.
    Deubiquitinase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein
    J Cell Sci (2018) 132, jcs221663-jcs221663. PubMed  Europe PubMed DOI
  69. Li,Z., Cheng,Z., Raghothama,C., Cui,Z., Liu,K., Li,X., Jiang,C., Jiang,W., Tan,M., Ni,X., Pandey,A., Liu,J.O. and Dang,Y.
    USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1
    Nucleic Acids Res (2018) 46, 823-839. PubMed  Europe PubMed DOI
  70. Ma,T., Chen,W., Zhi,X., Liu,H., Zhou,Y., Chen,B.W., Hu,L., Shen,J., Zheng,X., Zhang,S., Zhang,B., Li,H. and Liang,T.
    USP9X inhibition improves gemcitabine sensitivity in pancreatic cancer by inhibiting autophagy
    Cancer Lett (2018) 436, 129-138. PubMed  Europe PubMed DOI  I
  71. Miotto,B., Marchal,C., Adelmant,G., Guinot,N., Xie,P., Marto,J.A., Zhang,L. and Defossez,P.A.
    Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells
    Nucleic Acids Res (2018) 46, 4392-4404. PubMed  Europe PubMed DOI
  72. Zhang,Y., Duan,C., Yang,J., Chen,S., Liu,Q., Zhou,L., Huang,Z., Xu,Y. and Xu,G.
    Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1
    Biochem J (2018) 475, 1507-1522. PubMed  Europe PubMed DOI
  73. Zhu,C., Ji,X., Zhang,H., Zhou,Q., Cao,X., Tang,M., Si,Y., Yan,H., Li,L., Liang,T., Feng,X.H. and Zhao,B.
    Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway
    J Biol Chem (2018) 293, 1178-1191. PubMed  Europe PubMed DOI
    74. 2017
  74. Au,P.Y.B., Huang,L., Broley,S., Gallagher,L., Creede,E., Lahey,D., Ordorica,S., Mina,K., Boycott,K.M., Baynam,G. and Dyment,D.A.
    Two females with mutations in USP9X highlight the variable expressivity of the intellectual disability syndrome
    Eur J Med Genet (2017) 60, 359-364. PubMed  Europe PubMed DOI  M
  75. Bridges,C.R., Tan,M.C., Premarathne,S., Nanayakkara,D., Bellette,B., Zencak,D., Domingo,D., Gecz,J., Murtaza,M., Jolly,L.A. and Wood,S.A.
    USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors
    Sci Rep (2017) 7, 391-391. PubMed  Europe PubMed DOI
  76. Kishi,K., Uchida,A., Takase,H.M., Suzuki,H., Kurohmaru,M., Tsunekawa,N., Kanai-Azuma,M., Wood,S.A. and Kanai,Y.
    Spermatogonial deubiquitinase USP9X is essential for proper spermatogenesis in mice
    Reproduction (2017) 154, 135-143. PubMed  Europe PubMed DOI
  77. Wang,Q., Tang,Y., Xu,Y., Xu,S., Jiang,Y., Dong,Q., Zhou,Y. and Ge,W.
    The X-linked deubiquitinase USP9X is an integral component of centrosome
    J Biol Chem (2017) 292, 12874-12884. PubMed  Europe PubMed DOI
    78. 2016
  78. Karpel-Massler,G., Banu,M.A., Shu,C., Halatsch,M.E., Westhoff,M.A., Bruce,J.N., Canoll,P. and Siegelin,M.D.
    Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo
    Oncotarget (2016) 7, 12791-12805. PubMed  Europe PubMed DOI  I
  79. Kim,M., Kim,M., Park,S.J., Lee,C. and Lim,D.S.
    Role of angiomotin-like 2 mono-ubiquitination on YAP inhibition
    EMBO Rep (2016) 17, 64-78. PubMed  Europe PubMed DOI
  80. Naik,E. and Dixit,V.M.
    Usp9X is required for lymphocyte activation and homeostasis through its control of ZAP70 ubiquitination and PKCbeta kinase activity
    J Immunol (2016) 196, 3438-3451. PubMed  Europe PubMed DOI
  81. Reijnders,M.R., Zachariadis,V., Latour,B., Jolly,L., Mancini,G.M., Pfundt,R., Wu,K.M., van Ravenswaaij-Arts,C.M., Veenstra-Knol,H.E., Anderlid,B.M., Wood,S.A., Cheung,S.W., Barnicoat,A., Probst,F., Magoulas,P., Brooks,A.S., Malmgren,H., Harila-Saari,A., Marcelis,C.M., Vreeburg,M., Hobson,E., Sutton,V.R., Stark,Z., Vogt,J., Cooper,N., Lim,J.Y., Price,S., Lai,A.H., Domingo,D., Reversade,B., Gecz,J., Gilissen,C., Brunner,H.G., Kini,U., Roepman,R., Nordgren,A. and Kleefstra,T.
    De novo loss-of-function mutations in USP9X cause a female-specific recognizable syndrome with developmental delay and congenital malformations
    Am J Hum Genet (2016) 98, 373-381. PubMed  Europe PubMed DOI  M
  82. Wolfsperger,F., Hogh-Binder,S.A., Schittenhelm,J., Psaras,T., Ritter,V., Bornes,L., Huber,S.M., Jendrossek,V. and Rudner,J.
    Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms
    Cell Death Dis (2016) 7, e2039-e2039. PubMed  Europe PubMed DOI
  83. Yang,B., Zhang,S., Wang,Z., Yang,C., Ouyang,W., Zhou,F., Zhou,Y. and Xie,C.
    Deubiquitinase USP9X deubiquitinates beta-catenin and promotes high grade glioma cell growth
    Oncotarget (2016) 7, 79515-79525. PubMed  Europe PubMed DOI
    84. 2015
  84. Kushwaha,D., O'Leary,C., Cron,K.R., Deraska,P., Zhu,K., D'Andrea,A.D. and Kozono,D.
    USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1
    Cancer Biol Ther (2015) 16, 392-401. PubMed  Europe PubMed DOI  I
  85. Lawson,A.P., Long,M.J., Coffey,R.T., Qian,Y., Weerapana,E., El Oualid,F. and Hedstrom,L.
    Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes
    Cancer Res (2015) 75, 5130-5142. PubMed  Europe PubMed DOI  I
  86. Murtaza,M., Jolly,L.A., Gecz,J. and Wood,S.A.
    La FAM fatale: USP9X in development and disease
    Cell Mol Life Sci (2015) 72, 2075-2089. PubMed  Europe PubMed DOI  V
  87. Paemka,L., Mahajan,V.B., Ehaideb,S.N., Skeie,J.M., Tan,M.C., Wu,S., Cox,A.J., Sowers,L.P., Gecz,J., Jolly,L., Ferguson,P.J., Darbro,B., Schneider,A., Scheffer,I.E., Carvill,G.L., Mefford,H.C., El-Shanti,H., Wood,S.A., Manak,J.R. and Bassuk,A.G.
    Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase
    PLoS Genet (2015) 11, e1005022-e1005022. PubMed  Europe PubMed DOI
  88. Peterson,L.F., Sun,H., Liu,Y., Potu,H., Kandarpa,M., Ermann,M., Courtney,S.M., Young,M., Showalter,H.D., Sun,D., Jakubowiak,A., Malek,S.N., Talpaz,M. and Donato,N.J.
    Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies
    Blood (2015) 125, 3588-3597. PubMed  Europe PubMed DOI  I
  89. Zhao,Y., Majid,M.C., Soll,J.M., Brickner,J.R., Dango,S. and Mosammaparast,N.
    Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase
    EMBO J (2015) 34, 1687-1703. PubMed  Europe PubMed DOI
  90. Zhou,M., Wang,T., Lai,H., Zhao,X., Yu,Q., Zhou,J. and Yang,Y.
    Targeting of the deubiquitinase USP9X attenuates B-cell acute lymphoblastic leukemia cell survival and overcomes glucocorticoid resistance
    Biochem Biophys Res Commun (2015) 459, 333-339. PubMed  Europe PubMed DOI
    91. 2014
  91. Homan,C.C., Kumar,R., Nguyen,L.S., Haan,E., Raymond,F.L., Abidi,F., Raynaud,M., Schwartz,C.E., Wood,S.A., Gecz,J. and Jolly,L.A.
    Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth
    Am J Hum Genet (2014) 94, 470-478. PubMed  Europe PubMed DOI  PMC  EPMC  M
  92. Naik,E., Webster,J.D., Devoss,J., Liu,J., Suriben,R. and Dixit,V.M.
    Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X
    J Exp Med (2014) 211, 1947-1955. PubMed  Europe PubMed DOI  K
  93. Oosterkamp,H.M., Hijmans,E.M., Brummelkamp,T.R., Canisius,S., Wessels,L.F., Zwart,W. and Bernards,R.
    USP9X downregulation renders breast cancer cells resistant to tamoxifen
    Cancer Res (2014) 74, 3810-3820. PubMed  Europe PubMed DOI
  94. Peng,Z., Maxwell,D.S., Sun,D., Bhanu Prasad,B.A., Schuber,P.T., Jr., Pal,A., Ying,Y., Han,D., Gao,L., Wang,S., Levitzki,A., Kapuria,V., Talpaz,M., Young,M., Showalter,H.D., Donato,N.J. and Bornmann,W.G.
    Degrasyn-like symmetrical compounds: possible therapeutic agents for multiple myeloma (MM-I)
    Bioorg Med Chem (2014) 22, 1450-1458. PubMed  Europe PubMed DOI  I
  95. Wang,S., Kollipara,R.K., Srivastava,N., Li,R., Ravindranathan,P., Hernandez,E., Freeman,E., Humphries,C.G., Kapur,P., Lotan,Y., Fazli,L., Gleave,M.E., Plymate,S.R., Raj,G.V., Hsieh,J.T. and Kittler,R.
    Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer
    Proc Natl Acad Sci U S A (2014) 111, 4251-4256. PubMed  Europe PubMed DOI  I
    96. 2013
  96. Stegeman,S., Jolly,L.A., Premarathne,S., Gecz,J., Richards,L.J., Mackay-Sim,A. and Wood,S.A.
    Loss of USP9X disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis
    PLoS ONE (2013) 8, e68287-e68287. PubMed  Europe PubMed DOI  PMC  EPMC  K
    97. 2012
  97. Han,K.J., Foster,D.G., Zhang,N.Y., Kanisha,K., Dzieciatkowska,M., Sclafani,R.A., Hansen,K.C., Peng,J. and Liu,C.W.
    Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron
    J Biol Chem (2012) 287, 43741-43752. PubMed  Europe PubMed DOI
  98. Perez-Mancera,P.A., Rust,A.G., van der Weyden,L., Kristiansen,G., Li,A., Sarver,A.L., Silverstein,K.A., Grutzmann,R., Aust,D., Rummele,P., Knosel,T., Herd,C., Stemple,D.L., Kettleborough,R., Brosnan,J.A., Li,A., Morgan,R., Knight,S., Yu,J., Stegeman,S., Collier,L.S., ten Hoeve,J.J., de Ridder,J., Klein,A.P., Goggins,M., Hruban,R.H., Chang,D.K., Biankin,A.V., Grimmond,S.M., Wessels,L.F., Wood,S.A., Iacobuzio-Donahue,C.A., Pilarsky,C., Largaespada,D.A., Adams,D.J. and Tuveson,D.A.
    The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
    Nature (2012) 486, 266-270. PubMed  Europe PubMed DOI  PMC  EPMC
  99. Trivigno,D., Essmann,F., Huber,S.M. and Rudner,J.
    Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1
    Neoplasia (2012) 14, 893-904. PubMed  Europe PubMed  PMC  EPMC
    100. 2011
  100. Rott,R., Szargel,R., Haskin,J., Bandopadhyay,R., Lees,A.J., Shani,V. and Engelender,S.
    alpha-Synuclein fate is determined by USP9X-regulated monoubiquitination
    Proc Natl Acad Sci U S A (2011) 108, 18666-18671. PubMed  Europe PubMed DOI
    101. 2010
  101. Schwickart,M., Huang,X., Lill,J.R., Liu,J., Ferrando,R., French,D.M., Maecker,H., O'Rourke,K., Bazan,F., Eastham-Anderson,J., Yue,P., Dornan,D., Huang,D.C. and Dixit,V.M.
    Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
    Nature (2010) 463, 103-107. PubMed  Europe PubMed DOI
  102. Theard,D., Labarrade,F., Partisani,M., Milanini,J., Sakagami,H., Fon,E.A., Wood,S.A., Franco,M. and Luton,F.
    USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly
    EMBO J (2010) 29, 1499-1509. PubMed  Europe PubMed DOI
    103. 2009
  103. Dupont,S., Mamidi,A., Cordenonsi,M., Montagner,M., Zacchigna,L., Adorno,M., Martello,G., Stinchfield,M.J., Soligo,S., Morsut,L., Inui,M., Moro,S., Modena,N., Argenton,F., Newfeld,S.J. and Piccolo,S.
    FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
    Cell (2009) 136, 123-135. PubMed  Europe PubMed DOI
  104. Nagai,H., Noguchi,T., Homma,K., Katagiri,K., Takeda,K., Matsuzawa,A. and Ichijo,H.
    Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death
    Mol Cell (2009) 36, 805-818. PubMed  Europe PubMed DOI
    105. 2008
  105. Al-Hakim,A.K., Zagorska,A., Chapman,L., Deak,M., Peggie,M. and Alessi,D.R.
    Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains
    Biochem J (2008) 411, 249-260. PubMed  Europe PubMed DOI
  106. Nathan,J.A., Sengupta,S., Wood,S.A., Admon,A., Markson,G., Sanderson,C. and Lehner,P.J.
    The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X
    Traffic (2008) 9, 1130-1145. PubMed  Europe PubMed DOI
    107. 2006
  107. Mouchantaf,R., Azakir,B.A., McPherson,P.S., Millard,S.M., Wood,S.A. and Angers,A.
    The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X
    J Biol Chem (2006) 281, 38738-38747. PubMed  Europe PubMed DOI
    108. 2005
  108. Friocourt,G., Kappeler,C., Saillour,Y., Fauchereau,F., Rodriguez,M.S., Bahi,N., Vinet,M.C., Chafey,P., Poirier,K., Taya,S., Wood,S.A., Dargemont,C., Francis,F. and Chelly,J.
    Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes
    Mol Cell Neurosci (2005) 28, 153-164. PubMed  Europe PubMed DOI
  109. [YEAR:18-2-2005]Xu,J., Taya,S., Kaibuchi,K. and Arnold,A.P.
    Spatially and temporally specific expression in mouse hippocampus of Usp9x, a ubiquitin-specific protease involved in synaptic development
    J Neurosci Res (18-2-2005) 80, 47-55. PubMed  Europe PubMed DOI
  110. Xu,J., Taya,S., Kaibuchi,K. and Arnold,A.P.
    Sexually dimorphic expression of Usp9x is related to sex chromosome complement in adult mouse brain
    Eur J Neurosci (2005) 21, 3017-3022. PubMed  Europe PubMed DOI
  111. [YEAR:12-7-2005]Xu,J.
    Age-related changes in Usp9x protein expression and DNA methylation in mouse brain
    Brain Res Mol Brain Res (12-7-2005) 140, 17-24. PubMed  Europe PubMed DOI
    112. 2003
  112. Lee,K.H., Song,G.J., Kang,I.S., Kim,S.W., Paick,J.S., Chung,C.H. and Rhee,K.
    Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome
    Reprod Fertil Dev (2003) 15, 129-133. PubMed  Europe PubMed
    113. 1998
  113. Taya,S., Yamamoto,T., Kano,K., Kawano,Y., Iwamatsu,A., Tsuchiya,T., Tanaka,K., Kanai-Azuma,M., Wood,S.A., Mattick,J.S. and Kaibuchi,K.
    The Ras target AF-6 is a substrate of the Fam deubiquitinating enzyme
    J Cell Biol (1998) 142, 1053-1062. PubMed  Europe PubMed DOI  PMC  EPMC
    114. 1996
  114. Jones,M.H., Furlong,R.A., Burkin,H., Chalmers,I.J., Brown,G.M., Khwaja,O. and Affara,N.A.
    The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2
    Hum Mol Genet (1996) 5, 1695-1701. PubMed  Europe PubMed DOI

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