Literature for peptidase C19.015: ubiquitin-specific peptidase 14

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Cai,Z., Wu,H., Jiang,T., Ma,A., Meng,Z., Zhu,J., Lin,H., Liang,Y., Zhang,G. and Tan,M. The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth Neural Regen Res (2026) 21, 1641-1651. PubMed Europe PubMed DOI
Xie,H., Xue,Y., Deng,R., Chen,L., Wang,Y., Xu,J., Liu,H., Li,X., Cui,W. and Zhang,J. Hippocampal miR-124 mediates depression-like behavior via the USP14/REST signaling pathway in CRS- and CUMS-induced mouse models J Affect Disord (2026) 396, 120841-120841. PubMed Europe PubMed DOI

2025

Bao,D., Sha,X., Zhao,C., Xie,X., Lai,Y., Liu,L., Fan,R., Huang,W., Zhang,Y., Wu,G., Ye,D., Li,H. and Lai,C. Coelenterazine alleviates sepsis-associated acute kidney injury by inhibiting ferroptosis via the USP14-NCOA4 pathway Transl Androl Urol (2025) 14, 2606-2621. PubMed Europe PubMed DOI PMC EPMC
Bei,Y.H., Yu,K. and Wang,X. [The miR-30b/USP14 axis regulates mitophagy via a non-PINK1/Parkin pathway in neuronal oxygen-glucose deprivation/reoxygenation injury] Zhongguo Dang Dai Er Ke Za Zhi (2025) 27, 1526-1534. PubMed Europe PubMed DOI PMC EPMC
Chen,X., Ma,T., Chen,Y., Sun,Q., Wang,H. and Wang,Y. USP14 promotes osteoarthritis progression by deubiquitinating FZD8 to activate the Wnt/beta-catenin signaling pathway Immunobiology (2025) 230, 152905-152905. PubMed Europe PubMed DOI K
Ghosh,A. and Singh,J. Deubiquitinase USP-14 controls intestinal distension-induced immune activation in Caenorhabditis elegans via Wnt/beta-catenin signaling bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Hao,X. and Liu,Y. Ubiquitin-specific peptidase 14 promotes neuron injury by stabilizing acyl-CoA synthetase long-chain family member 4 through deubiquitination Cytojournal (2025) 22, 11-11. PubMed Europe PubMed DOI PMC EPMC K
Jha,S., Pispa,J. and Holmberg,C.I. Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy Biol Open (2025) 14 PubMed Europe PubMed DOI K
Kang,S.W., Park,J.E., Ok,S., Um,M., Son,H., Byun,S., Park,N., Lee,S.J., Tran,T.X.T., Kim,G., Yeom,J., Kim,K., Kim,E.Y. and Kang,M.J. Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB Commun Biol (2025) 8, 191-191. PubMed Europe PubMed DOI PMC EPMC K
Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C. Recent advances in small molecule inhibitors of deubiquitinating enzymes Eur J Med Chem (2025) 287, 117324-117324. PubMed Europe PubMed DOI V
Qian,J., Zhao,Z., Ma,L., Liu,W. and Song,Y. USP14 targets FABP5-mediated ferroptosis to promote proliferation and cisplatin resistance of HNSCC Clin Transl Oncol (2025) PubMed Europe PubMed DOI
Qian,Y., Wu,J., Yang,W., Lyu,R., You,Q., Li,J., He,Q., Zhuang,Y., Wang,W., Wang,Y., Zhu,Y., Wu,Z. and Chen,D. FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway Nat Commun (2025) 16, 1519-1519. PubMed Europe PubMed DOI PMC EPMC
Salomonsson,J., Sjostrand,L., Eskilson,A., Derbyshire,D., D'Arcy,P., Sunnerhagen,M. and Ahlner,A. Dynamic networks connect the USP14 active site region with the proteasome interaction surface Protein Sci (2025) 34, e70077-e70077. PubMed Europe PubMed DOI PMC EPMC
Srinivasan,V., Soliymani,R., Ivanova,L., Eriksson,O., Peitsaro,N., Lalowski,M., Karelson,M. and Lindholm,D. USP14 is crucial for proteostasis regulation and alpha-synuclein degradation in human SH-SY5Y dopaminergic cells Heliyon (2025) 11, e42031-e42031. PubMed Europe PubMed DOI PMC EPMC
Wang,Z., Yu,C., Xie,G., Tao,K., Yin,Z. and Lv,Q. USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer Mol Med (2025) 31, 163-163. PubMed Europe PubMed DOI PMC EPMC K
You,L., Wang,Q., Zhang,T., Xiao,H., Lv,M., Lv,H., Deng,L., Zhang,X. and Zhang,Y. USP14-IMP2-CXCL2 axis in tumor-associated macrophages facilitates resistance to anti-PD-1 therapy in gastric cancer by recruiting myeloid-derived suppressor cells Oncogene (2025) PubMed Europe PubMed DOI
Yu,L., Zheng,X., Wu,Y. and Ge,K. USP14-Dependent IGF1R Aggravates High Glucose-Induced Diabetic Retinopathy by Upregulating BAP1 Appl Biochem Biotechnol (2025) PubMed Europe PubMed DOI
Yuan,Y., Niu,Y., Huang,Z., Shi,Y., Lin,Z., Zuo,D., Zhong,C., Li,K., Guan,X.Y., Yuan,Y. and Li,B. USP14-mediated metabolic competition impairs CD8+ T cell immunosurveillance in hepatocellular carcinoma Proc Natl Acad Sci U S A (2025) 122, e2510576122-e2510576122. PubMed Europe PubMed DOI PMC EPMC
Zhang,A., Zhang,H., Liu,L., Zhang,H., Mo,L., Zhang,W., Harith,H.H., Cheng,L., Lv,J., Tham,C.L. and Yang,P. USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy Cell Immunol (2025) 411-412, 104943-104943. PubMed Europe PubMed DOI
Zhang,S., Han,B., Jiang,B., Chen,M., Mu,D., Wang,Q., Sun,S., Xu,T., Song,F., Ren,X., Pan,Z., Huang,P. and Ge,M. USP14 and UCHL5 synergistically deubiquitinate PKCalpha and translocate NF-kappaB to promote the progression of anaplastic thyroid cancer Cell Death Dis (2025) 16, 617-617. PubMed Europe PubMed DOI PMC EPMC K
Zhang,Y., Zhou,L., Fu,Q. and Liu,Z. FOXG1 promotes osteogenesis of bone marrow-derived mesenchymal stem cells by activating autophagy through regulating USP14 Commun Biol (2025) 8, 59-59. PubMed Europe PubMed DOI PMC EPMC K
Zhao,Q., Wang,X., Zhang,T., Guo,S., Liu,X., Wan,S., Guo,Y., Zhang,Q., Li,J., Wang,S. and Dong,L. Piceatannol upregulates USP14-mediated GPX4 deubiquitination to inhibit neuronal ferroptosis caused by cerebral ischemia-reperfusion in mice Food Chem Toxicol (2025) 197, 115281-115281. PubMed Europe PubMed DOI K
Zhou,X., Xia,Q., Wang,B., Li,J., Liu,B., Wang,S., Huang,M., Zhong,R., Cheng,S.Y., Wang,X., Jiang,X. and Huang,T. USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5 Theranostics (2025) 15, 2293-2314. PubMed Europe PubMed DOI PMC EPMC

2024

Alhasan,B.A., Morozov,A.V., Guzhova,I.V. and Margulis,B.A. The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence Biochim Biophys Acta Rev Cancer (2024) 1879, 189119-189119. PubMed Europe PubMed DOI V
Ba,L., E,M., Wang,R., Wu,N., Wang,R., Liu,R., Feng,X., Qi,H., Sun,H. and Qiao,G. Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway Heliyon (2024) 10, e24010-e24010. PubMed Europe PubMed DOI PMC EPMC K
Bai,T., Mai,R.Y., Tang,Z.H., Wang,X.B., Chen,J., Ye,J.Z., Wei,M., Zhang,B., Li,K., Gu,Z.M., Wu,F.X. and Li,L.Q. Ubiquitination of P53 Regulated by Ubiquitin-Specific Protease 14 Delays the Invasion of Hepatitis B Virus and the Development of Hepatitis Viral Immunol (2024) 37, 432-439. PubMed Europe PubMed DOI
Bian,J., Ge,W. and Jiang,Z. miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-kappaB Signaling Pathway J Ophthalmol (2024) 2024, 1470898-1470898. PubMed Europe PubMed DOI PMC EPMC K
Chen,Y., Feng,Y., Lin,Y., Zhou,X., Wang,L., Zhou,Y., Lin,K. and Cai,L. GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4 Br J Cancer (2024) 130, 755-768. PubMed Europe PubMed DOI PMC EPMC
Dash,R., Tran,N.N., Lee,S.B. and Lee,B.H. Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation Cells (2024) 13 PubMed Europe PubMed DOI PMC EPMC
Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M., Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P. Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in Parkinson's disease Cell Mol Life Sci (2024) 81, 232-232. PubMed Europe PubMed DOI PMC EPMC K
Favaro,M., Mauri,S., Bernardo,G., Zordan,M.A., Mazzotta,G.M. and Ziviani,E. Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson's disease Front Neurosci (2024) 18, 1410139-1410139. PubMed Europe PubMed DOI PMC EPMC
Gao,J. and Gao,Z. The regulatory role and mechanism of USP14 in endothelial cell pyroptosis induced by coronary heart disease Clin Hemorheol Microcirc (2024) 86, 495-508. PubMed Europe PubMed DOI
Greta,B., Prado Miguel,A., Roshani,D.A., Favaro,M., Mauri,S., Borsetto,A., Marchesan,E., Paulo,J.A., Gygi,S.P., Finley,D.J. and Ziviani,E. USP14 inhibition enhances Parkin-independent mitophagy in iNeurons Pharmacol Res (2024) , 107484-107484. PubMed Europe PubMed DOI
Gubat,J., Sjostrand,L., Selvaraju,K., Telli,K. and D'Arcy,P. Loss of the proteasomal deubiquitinase USP14 induces growth defects and a senescence phenotype in colorectal cancer cells Sci Rep (2024) 14, 13037-13037. PubMed Europe PubMed DOI PMC EPMC
Kim,H., Kim,H., Lee,S.H., Kwon,J.H., Byun,S., Yoo,J.Y., Park,S.Y. and Yoon,H.G. Deubiquitinase inhibitor bAP-15 suppresses renal epithelial to mesenchymal transition via inhibition of p300 stability Biochem Biophys Res Commun (2024) 741, 151095-151095. PubMed Europe PubMed DOI I
Lei,K., Liang,R., Liang,J., Lu,N., Huang,J., Xu,K., Tan,B., Wang,K., Liang,Y., Wang,W., Lin,H. and Wang,M. CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1 J Exp Clin Cancer Res (2024) 43, 124-124. PubMed Europe PubMed DOI PMC EPMC
Li,G., Zhou,C., Wang,L., Zheng,Y., Zhou,B., Li,G., Ma,Z., Sun,P., Deng,Y., Su,L., Wang,J. and Cui,H. MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14 Pigment Cell Melanoma Res (2024) 37, 316-328. PubMed Europe PubMed DOI I
Li,M., Zhao,Y., Zhang,J., Jiang,W., Peng,S., Hu,J. and Shen,Y. Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro Eur J Histochem (2024) 68 PubMed Europe PubMed DOI
Li,P., Zhu,X., Qu,H., Han,Z., Yao,X., Wei,Y., Li,B. and Chen,H. Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells Onco Targets Ther (2024) 17, 741-753. PubMed Europe PubMed DOI PMC EPMC
Li,Y., Dong,B., Wang,Y., Bi,H., Zhang,J., Ding,C., Wang,C., Ding,X. and Xue,W. Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy Transl Res (2024) 270, 94-103. PubMed Europe PubMed DOI K
Liu,D., Li,M., Zhao,Z., Zhou,L., Zhi,F., Guo,Z. and Cui,J. Targeting the TRIM14/USP14 Axis Enhances Immunotherapy Efficacy by Inducing Autophagic Degradation of PD-L1 Cancer Res (2024) 84, 2806-2819. PubMed Europe PubMed DOI
Liu,Y., Xun,W., Zhao,T., Huang,M., Sun,L., Wen,G., Kang,X., Wang,J. and Han,T. Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma Commun Biol (2024) 7, 1365-1365. PubMed Europe PubMed DOI PMC EPMC
Ma,L.Z., Wang,A., Lai,Y.H., Zhang,J., Zhang,X.F., Chen,S.L. and Zhou,X.Y. USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency J Transl Med (2024) 22, 834-834. PubMed Europe PubMed DOI PMC EPMC I
Nogami,A., Amemiya,H.J., Fujiwara,H., Umezawa,Y., Tohda,S. and Nagao,T. Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC K I
Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M. Deubiquitinases in muscle physiology and disorders Biochem Soc Trans (2024) 52, 1085-1098. PubMed Europe PubMed DOI V
Rong,Q., Xi,Z., Guo,D., Xu,W., Zhang,L. and Wu,Q. Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila J Virol (2024) , e0017724-e0017724. PubMed Europe PubMed DOI
Song,H., Qiu,J. and Hua,K. USP14 promotes the proliferation of cervical cancer via upregulating beta-catenin Environ Toxicol (2024) 39, 1031-1043. PubMed Europe PubMed DOI K
Wang,C., Fu,W., Zhang,Y., Hu,X., Xu,Q. and Tong,X. C-MYC-activated lncRNA SNHG20 accelerates the proliferation of diffuse large B cell lymphoma via USP14-mediated deubiquitination of beta-catenin Biol Direct (2024) 19, 47-47. PubMed Europe PubMed DOI PMC EPMC K
Wei,D., Tian,X., Ren,Z., Liu,Z. and Sun,C. Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity Int J Biol Macromol (2024) 267, 131645-131645. PubMed Europe PubMed DOI K
Xia,X., Liu,X., Xu,Q., Gu,J., Ling,S., Liu,Y., Li,R., Zou,M., Jiang,S., Gao,Z., Chen,C., Liu,S. and Liu,N. USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein Cell Death Discov (2024) 10, 295-295. PubMed Europe PubMed DOI PMC EPMC
Xu,M.H., Zheng,Y.M., Liang,B.G., Xu,W.X., Cao,J., Wang,P., Dong,Z.Y., Zhou,C.H., Sun,H.C., Ren,N., Ke,A.W. and Shen,Y.H. Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma Int J Biol Sci (2024) 20, 3269-3284. PubMed Europe PubMed DOI PMC EPMC K
Yang,C., Shu,J., Yang,X., Miao,Y., Liu,J., Li,J., Xiao,J., Kong,W., Xu,Z. and Feng,H. USP14 negatively regulates IFN signaling by dampening K63-linked ubiquitination of TBK1 in black carp Fish Shellfish Immunol (2024) 149, 109559-109559. PubMed Europe PubMed DOI
Yuan,F., Xu,J., Xuan,L., Deng,C., Wang,W. and Yang,R. USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer Neoplasia (2024) 60, 101101-101101. PubMed Europe PubMed DOI K
Zhang,N., Zhang,H., Yang,X., Xue,Q., Wang,Q., Chang,R., Zhu,L., Chen,Z. and Liu,X. USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axis BMC Cancer (2024) 24, 237-237. PubMed Europe PubMed DOI PMC EPMC
Zhang,X., Geng,L., Tang,Y., Wang,Y., Zhang,Y., Zhu,C., Lei,H., Xu,H., Zhu,Q., Wu,Y. and Gu,W. Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma J Transl Med (2024) 22, 193-193. PubMed Europe PubMed DOI PMC EPMC
Zhang,Z., Guo,Q., Ma,C., Zhao,Z., Shi,Q., Yu,H., Rao,L. and Li,M. USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis Mol Med (2024) 30, 32-32. PubMed Europe PubMed DOI PMC EPMC K
Zhang,Z., Jin,B., Zhang,Y., Yang,M., Wang,C., Zhu,Y., Li,T., Lin,J., Yang,M., Cheng,Y., Xu,S., He,K., Xu,J., Mi,Y., Jiang,J. and Sun,Z. USP14 modulates cell pyroptosis and ameliorates doxorubicin-induced cardiotoxicity by deubiquitinating and stabilizing SIRT3 Free Radic Biol Med (2024) 225, 741-757. PubMed Europe PubMed DOI K

2023

Cui,Y., Luo,L., Zeng,Z., Liu,X., Li,T., He,X., Ma,Y., Meng,W., Zeng,H., Long,Y., Zong,D. and Chen,Y. MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells Cell Death Dis (2023) 14, 2-2. PubMed Europe PubMed DOI PMC EPMC
Ding,W., Wang,J.X., Wu,J.Z., Liu,A.C., Jiang,L.L., Zhang,H.C., Meng,Y., Liu,B.Y., Peng,G.J., Lou,E.Z., Mao,Q., Zhou,H., Tang,D.L., Chen,X., Liu,J.B. and Shi,X.P. Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells Acta Pharmacol Sin (2023) 44, 2537-2548. PubMed Europe PubMed DOI
Du,X.H., Ke,S.B., Liang,X.Y., Gao,J., Xie,X.X., Qi,L.Z., Liu,X.Y., Xu,G.Y., Zhang,X.D., Du,R.L. and Li,S.Z. USP14 promotes colorectal cancer progression by targeting JNK for stabilization Cell Death Dis (2023) 14, 56-56. PubMed Europe PubMed DOI PMC EPMC
Fu,Y., Qiu,J., Wu,J., Zhang,L., Wei,F., Lu,L., Wang,C., Zeng,Z., Liang,S. and Zheng,J. USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis Biochim Biophys Acta Mol Cell Biol Lipids (2023) 1868, 159258-159258. PubMed Europe PubMed DOI
Ge,J., Wang,Y., Chen,X., Yu,K., Luo,Z.Q., Liu,X. and Qiu,J. Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome Cell Rep (2023) 42, 112817-112817. PubMed Europe PubMed DOI
Gong,X., Jia,L., Zhou,L. and Hu,T. USP14 predicts poorer survival outcomes and promotes tumor progression in endometrial carcinoma by activating NF-kappaB signaling Aging (Albany NY) (2023) 15, 12120-12135. PubMed Europe PubMed DOI PMC EPMC K
He,F., Chen,Y., He,D. and He,S. USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization Biochem Biophys Res Commun (2023) 646, 19-29. PubMed Europe PubMed DOI
Ji,J., Lv,J., Lv,M., Jing,A., Xu,M., Yuan,Q., Ma,X., Qian,Q., Wang,W., Geng,T., Ding,Y., Qin,J., Liu,Y., Yang,J., Zhou,J., Ma,L., Wang,Y., Zuo,L., Wang,X., Ma,S. and Liu,B. USP14 regulates heme metabolism and ovarian cancer invasion through BACH1 deubiquitination and stabilization Biochem Biophys Res Commun (2023) 667, 186-193. PubMed Europe PubMed DOI K
Jin,S., Tsunematsu,T., Horiguchi,T., Mouri,Y., Shao,W., Miyoshi,K., Hagita,H., Sarubo,M., Fujiwara,N., Qi,G., Ishimaru,N. and Kudo,Y. Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma Cancer Med (2023) 12, 22156-22169. PubMed Europe PubMed DOI PMC EPMC
Lee,M.Y., Kim,M.J., Jin,J.O. and Lee,P.C. USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer BMB Rep (2023) 56, 451-456. PubMed Europe PubMed DOI PMC EPMC K
Lin,C., Li,L., Xu,Q., Xu,S. and Tang,C. Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse Mol Neurobiol (2023) 60, 4273-4287. PubMed Europe PubMed DOI
Morgan,E.L., Toni,T., Viswanathan,R., Robbins,Y., Yang,X., Cheng,H., Gunti,S., Huynh,A., Sowers,A.L., Mitchell,J.B., Allen,C.T., Chen,Z. and Van Waes,C. Inhibition of USP14 promotes TNFalpha-induced cell death in head and neck squamous cell carcinoma (HNSCC) Cell Death Differ (2023) 30, 1382-1396. PubMed Europe PubMed DOI PMC EPMC
Morrow,N.M. and Mulvihill,E.E. Complexity in Hepatic Insulin Resistance - Unraveling the Role of Ubiquitin-Specific Protease 14 in Protein Homeostasis of Metabolic Transcription Factors J Pharmacol Exp Ther (2023) 385, 1-4. PubMed Europe PubMed DOI
Su,Y., Zeng,K., Liu,S., Wu,Y., Wang,C., Wang,S., Lin,L., Zou,R., Sun,G., Luan,R., Zhou,B., Bai,Y., Niu,J., Zhang,Y. and Zhao,Y. Ubiquitin-specific peptidase 14 maintains estrogen receptor alpha stability via its deubiquitination activity in endometrial cancer J Biol Chem (2023) 299, 102734-102734. PubMed Europe PubMed DOI PMC EPMC K
Wang,J., Xiang,Y., Xie,Z., Fan,M., Fang,S., Wan,H., Zhao,R., Zeng,F. and Hua,Q. USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization Cancers (Basel) (2023) 15 PubMed Europe PubMed DOI PMC EPMC
Wei,D., Tian,X., Zhu,L., Wang,H. and Sun,C. USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1 Cell Death Dis (2023) 14, 566-566. PubMed Europe PubMed DOI PMC EPMC K
Wu,J., Pang,X., Yang,X., Zhang,M., Chen,B., Fan,H., Wang,H., Yu,X., Tang,Y. and Liang,X. M1 macrophages induce PD-L1(hi) cell-led collective invasion in HPV-positive head and neck squamous cell carcinoma via TNF-alpha/CDK4/UPS14 J Immunother Cancer (2023) 11 PubMed Europe PubMed DOI PMC EPMC
Xiang,J., Zhang,N., Du,A., Li,J., Luo,M., Wang,Y., Liu,M., Yang,L., Li,X., Wang,L., Liu,Q., Chen,D., Wang,T., Bian,X.W., Qin,Z.Y., Su,L., Wen,L. and Wang,B. A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer Adv Sci (Weinh) (2023) 10, e2305550-e2305550. PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Lu,P., Jin,S., Zhang,J. and Zhou,Y. USP14 promotes the malignant progression and ibrutinib resistance of mantle cell lymphoma by stabilizing XPO1 Int J Med Sci (2023) 20, 616-626. PubMed Europe PubMed DOI PMC EPMC

2022

Hai,B., Mao,T., Du,C., Jia,F., Liu,Y., Song,Q., Pan,X., Liu,X. and Zhu,B. USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3 Acta Biochim Biophys Sin (Shanghai) (2022) 54, 1-11. PubMed Europe PubMed DOI PMC EPMC K
Jiang,L., He,Q., Chen,X., Liu,A., Ding,W., Zhang,H., Chen,X., Zhou,H., Meng,Y., Liu,B., Peng,G., Wang,C., Liu,J. and Shi,X. Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia Clin Transl Med (2022) 12, e1038-e1038. PubMed Europe PubMed DOI PMC EPMC I
Jiang,Z.Y., Hong,J., Zhang,J.H., Wang,X.F., Ma,Y.S., Xiong,Z.X., Sun,H.R., Cheng,C., Xie,B.Z., Liu,J.B., Ouyang,Y.G. and Fu,D. Treatment with b-AP15 to Inhibit UCHL5 and USP14 Deubiquitinating Activity and Enhance p27 and Cyclin E1 for Tumors with p53 Deficiency Technol Cancer Res Treat (2022) 21, 15330338221119745-15330338221119745. PubMed Europe PubMed DOI PMC EPMC I
Liu,D., Zhao,Z., She,Y., Zhang,L., Chen,X., Ma,L. and Cui,J. TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation Proc Natl Acad Sci U S A (2022) 119 PubMed Europe PubMed DOI PMC EPMC
Shi,D., Wu,X., Jian,Y., Wang,J., Huang,C., Mo,S., Li,Y., Li,F., Zhang,C., Zhang,D., Zhang,H., Huang,H., Chen,X., Wang,Y.A., Lin,C., Liu,G., Song,L. and Liao,W. USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer Nat Commun (2022) 13, 5644-5644. PubMed Europe PubMed DOI PMC EPMC
van der Wal,L., Bezstarosti,K. and Demmers,J.A.A. A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37 J Proteomics (2022) 262, 104592-104592. PubMed Europe PubMed DOI I
Wang,D., Jin,X., Lei,M., Jiang,Y., Liu,Y., Yu,F., Guo,Y., Han,B., Yang,Y., Sun,W., Liu,Y., Zeng,G., Liu,F., Hu,J. and Chen,X. USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling Int J Biol Sci (2022) 18, 2452-2471. PubMed Europe PubMed DOI PMC EPMC K
Wang,S., Wang,T., Yang,Q., Cheng,S., Liu,F., Yang,G., Wang,F., Wang,R., Yang,D., Zhou,M., Duan,C., Zhang,Y., Liu,H., Dai,Z., Tian,K. and Liu,S. Proteasomal deubiquitylase activity enhances cell surface recycling of the epidermal growth factor receptor in non-small cell lung cancer Cell Oncol (Dordr) (2022) 45, 951-965. PubMed Europe PubMed DOI I
Wu,T., Li,C., Zhou,C., Niu,X., Li,G., Zhou,Y., Gu,X. and Cui,H. Inhibition of USP14 enhances anti-tumor effect in vemurafenib-resistant melanoma by regulation of Skp2 Cell Biol Toxicol (2022) PubMed Europe PubMed DOI K
Zhang,B., Zhang,M., Yang,Y., Li,Q., Yu,J., Zhu,S., Niu,Y. and Shang,Z. Targeting KDM4A-AS1 represses AR/AR-Vs deubiquitination and enhances enzalutamide response in CRPC Oncogene (2022) 41, 387-399. PubMed Europe PubMed DOI K
Zhang,S., Zou,S., Yin,D., Zhao,L., Finley,D., Wu,Z. and Mao,Y. USP14-regulated allostery of the human proteasome by time-resolved cryo-EM Nature (2022) 605, 567-574. PubMed Europe PubMed DOI PMC EPMC

2021

Hang,C., Gong,C., Fang,Y., Chen,L. and Zhu,J. Ubiquitin-specific protease 14 (USP14) promotes proliferation and metastasis in pancreatic ductal adenocarcinoma J Mol Histol (2021) PubMed Europe PubMed DOI K
Huang,C., Cao,H., Qin,J., Xu,L., Hu,F., Gu,Y., Dou,C. and Zhang,S. Ubiquitin-Specific Protease 14 (USP14) Aggravates Inflammatory Response and Apoptosis of Lung Epithelial Cells in Pneumonia by Modulating Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inflammation (2021) PubMed Europe PubMed DOI
Li,H., Quan,J., Zhao,X., Ling,J. and Chen,W. USP14 negatively regulates RIG-I-mediated IL-6 and TNF-alpha production by inhibiting NF-kappaB activation Mol Immunol (2021) 130, 69-76. PubMed Europe PubMed DOI K
Moon,S., Muniyappan,S., Lee,S.B. and Lee,B.H. Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases Int J Mol Sci (2021) 22, 6213-6213. PubMed Europe PubMed DOI PMC EPMC I
Tian,T., McLean,J.W., Wilson,J.A. and Wilson,S.M. Examination of genetic and pharmacological tools to study the proteasomal deubiquitinating enzyme ubiquitin-specific protease 14 in the nervous system J Neurochem (2021) 156, 309-323. PubMed Europe PubMed DOI
Wang,D., Ma,H., Zhao,Y. and Zhao,J. Ubiquitin-specific protease 14 is a new therapeutic target for the treatment of diseases J Cell Physiol (2021) 236, 3396-3405. PubMed Europe PubMed DOI V
Wang,F., Ning,S., Yu,B. and Wang,Y. USP14: Structure, Function, and Target Inhibition Front Pharmacol (2021) 12, 801328-801328. PubMed Europe PubMed DOI PMC EPMC V
Yan,G., Liu,N.A., Wang,J., Tian,J., Liu,H., Li,S., Liu,W., Li,X., Li,K. and Wang,H. Deubiquitylation and stabilization of Acf7 by ubiquitin carboxylterminal hydrolase 14 (USP14) is critical for NSCLC migration J Biosci (2021) 46 PubMed Europe PubMed K
Yang,J.S., Yoon,N., Kong,M., Jung,B.H., Lee,H. and Park,J. USP14 Regulates Cancer Cell Growth in a Fatty Acid Synthase-Independent Manner Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC I

2020

Adelakun,N., Obaseki,I., Adeniyi,A., Fapohunda,O., Obaseki,E. and Omotuyi,O. Discovery of new promising USP14 inhibitors: computational evaluation of the thumb-palm pocket J Biomol Struct Dyn (2020) , 1-11. PubMed Europe PubMed DOI I
Banerjee,C., Roy,M., Mondal,R. and Chakraborty,J. USP14 as a Therapeutic Target Against Neurodegeneration: A Rat Brain Perspective Front Cell Dev Biol (2020) 8, 727-727. PubMed Europe PubMed DOI PMC EPMC
Dong,F., Ruan,S., Wang,J., Xia,Y., Le,K., Xiao,X., Hu,T. and Wang,Q. M2 macrophage-induced lncRNA PCAT6 facilitates tumorigenesis and angiogenesis of triple-negative breast cancer through modulation of VEGFR2 Cell Death Dis (2020) 11, 728-728. PubMed Europe PubMed DOI PMC EPMC
Gao,L., Zhang,W., Zhang,J., Liu,J., Sun,F., Liu,H., Hu,J., Wang,X., Wang,X., Su,P., Chen,S., Qu,S., Shi,B., Xiong,X., Chen,W., Dong,X. and Han,B. KIF15-mediated stabilization of AR and AR-V7 contributes to enzalutamide resistance in prostate cancer Cancer Res (2020) PubMed Europe PubMed DOI
Geng,L., Chen,X., Zhang,M. and Luo,Z. Ubiquitin-specific protease 14 promotes prostate cancer progression through deubiquitinating the transcriptional factor ATF2 Biochem Biophys Res Commun (2020) 524, 16-21. PubMed Europe PubMed DOI
Huang,L., Zhang,Y., Zheng,J., Ni,N., Qin,Q., Huang,X. and Huang,Y. Grouper ubiquitin-specific protease 14 promotes iridovirus replication through negatively regulating interferon response Fish Shellfish Immunol (2020) 105, 253-262. PubMed Europe PubMed DOI
Kovacs,L., Nagy,A., Pal,M. and Deak,P. Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster J Cell Sci (2020) 133 PubMed Europe PubMed DOI
Ma,Y.S., Wang,X.F., Zhang,Y.J., Luo,P., Long,H.D., Li,L., Yang,H.Q., Xie,R.T., Jia,C.Y., Lu,G.X., Chang,Z.Y., Zhang,J.J., Xue,S.B., Lv,Z.W., Yu,F., Xia,Q. and Fu,D. Inhibition of USP14 deubiquitinating activity as a potential therapy for tumors with p53 deficiency Mol Ther Oncolytics (2020) 16, 147-157. PubMed Europe PubMed DOI PMC EPMC
Ma,Y.S., Wang,X.F., Yu,F., Wu,T.M., Liu,J.B., Zhang,Y.J., Xia,Q., Jiang,Z.Y., Lin,Q.L. and Fu,D. Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency Signal Transduct Target Ther (2020) 5, 30-30. PubMed Europe PubMed DOI PMC EPMC I
Moghadami,A.A., Aboutalebi Vand Beilankouhi,E., Kalantary-Charvadeh,A., Hamzavi,M., Mosayyebi,B., Sedghi,H., Ghorbani Haghjo,A. and Nazari Soltan Ahmad,S. Inhibition of USP14 induces ER stress-mediated autophagy without apoptosis in lung cancer cell line A549 Cell Stress Chaperones (2020) PubMed Europe PubMed DOI K I
Park,J.E., Tran,T.X.T., Park,N., Yeom,J., Kim,K. and Kang,M.J. The Function of Drosophila USP14 in Endoplasmic Reticulum Stress and Retinal Degeneration in a Model for Autosomal Dominant Retinitis Pigmentosa Biology (Basel) (2020) 9 PubMed Europe PubMed DOI
Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H. Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V
Sharma,A., Alswillah,T., Kapoor,I., Debjani,P., Willard,B., Summers,M.K., Gong,Z. and Almasan,A. USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells Nucleic Acids Res (2020) 48, 736-747. PubMed Europe PubMed DOI
Sharma,A. and Almasan,A. USP14 Regulates DNA Damage Response and Is a Target for Radiosensitization in Non-Small Cell Lung Cancer Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC K I
Shen,J., Hong,L. and Chen,L. Ubiquitin-specific protease 14 regulates ovarian cancer cisplatin-resistance by stabilizing BCL6 oncoprotein Biochem Biophys Res Commun (2020) 524, 683-688. PubMed Europe PubMed DOI
Shin,J.Y., Muniyappan,S., Tran,N.N., Park,H., Lee,S.B. and Lee,B.H. Deubiquitination Reactions on the Proteasome for Proteasome Versatility Int J Mol Sci (2020) 21, 5312-5312. PubMed Europe PubMed DOI
Tsai,Y., Xia,C. and Sun,Z. The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro Front Pharmacol (2020) 11, 598555-598555. PubMed Europe PubMed DOI PMC EPMC
Xie,W. and Xu,L. Ubiquitin-specific protease 14 promotes radio-resistance and suppresses autophagy in oral squamous cell carcinoma Exp Cell Res (2020) , 112385-112385. PubMed Europe PubMed DOI K
Xu,L., Wang,J., Yuan,X., Yang,S., Xu,X., Li,K., He,Y., Wei,L., Zhang,J. and Tian,Y. IU1 suppresses proliferation of cervical cancer cells through MDM2 degradation Int J Biol Sci (2020) 16, 2951-2963. PubMed Europe PubMed DOI PMC EPMC I

2019

Castro,I., Ekinci,E., Huang,X., Cheaito,H.A., Ahn,Y.H., Olivero-Verbel,J. and Dou,Q.P. Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds J Cell Biochem (2019) 120, 14065-14075. PubMed Europe PubMed DOI
Chadchankar,J., Korboukh,V., Conway,L.C., Wobst,H.J., Walker,C.A., Doig,P., Jacobsen,S.J., Brandon,N.J., Moss,S.J. and Wang,Q. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells PLoS ONE (2019) 14, e0225145-e0225145. PubMed Europe PubMed DOI PMC EPMC
Han,K.H., Kwak,M., Lee,T.H., Park,M.S., Jeong,I.H., Kim,M.J., Jin,J.O. and Lee,P.C. USP14 Inhibition regulates tumorigenesis by inducing autophagy in lung cancer in vitro Int J Mol Sci (2019) 20 PubMed Europe PubMed DOI I
Li,H., Zhao,Z., Ling,J., Pan,L., Zhao,X., Zhu,H., Yu,J., Xie,B., Shen,J. and Chen,W. USP14 promotes K63-linked RIG-I deubiquitination and suppresses antiviral immune responses Eur J Immunol (2019) 49, 42-53. PubMed Europe PubMed DOI I
Li,M., Zhao,J. and Jia,L. USP14-mediated IkappaBalpha degradation exacerbates NF-kappaB activation and IL-1beta-stimulated chondrocyte dedifferentiation Life Sci (2019) 218, 147-152. PubMed Europe PubMed DOI
Liu,B., Liu,Y., Wang,Y., Xie,C., Gan,M., Han,T., Cao,J. and Wang,J. Cyclin B1 deubiquitination by USP14 regulates cell cycle progression in breast cancer Pathol Res Pract (2019) , 152592-152592. PubMed Europe PubMed DOI
Liu,B., Zhang,Z., Hu,Y., Lu,Y., Li,D., Liu,J., Liao,S., Hu,M., Wang,Y., Zhang,D., Chen,Y., Qian,Q., Lv,X., Wu,D., Tan,M., Hu,C., Xiong,X. and Li,X. Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14 Proc Natl Acad Sci U S A (2019) 116, 21732-21738. PubMed Europe PubMed DOI
Liu,B., Chen,J. and Zhang,S. Emerging role of ubiquitin-specific protease 14 in oncogenesis and development of tumor: therapeutic implication Life Sci (2019) 239, 116875-116875. PubMed Europe PubMed DOI
Luo,H., Wang,X., Ge,H., Zheng,N., Peng,F., Fu,Y., Tao,L. and Wang,Q. Inhibition of ubiquitinspecific protease 14 promotes connexin 32 internalization and counteracts cisplatin cytotoxicity in human ovarian cancer cells Oncol Rep (2019) 42, 1237-1247. PubMed Europe PubMed DOI
Massa,F., Tammaro,R., Prado,M.A., Cesana,M., Lee,B.H., Finley,D., Franco,B. and Morleo,M. The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling Hum Mol Genet (2019) 28, 764-777. PubMed Europe PubMed DOI
Muniyappan,S. and Lee,B.H. In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation Methods Enzymol (2019) 619, 249-268. PubMed Europe PubMed DOI
Wertz,I.E. and Murray,J.M. Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms Drug Discov Today Technol (2019) 31, 109-123. PubMed Europe PubMed DOI V I
Xia,X., Huang,C., Liao,Y., Liu,Y., He,J., Guo,Z., Jiang,L., Wang,X., Liu,J. and Huang,H. Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide J Exp Clin Cancer Res (2019) 38, 220-220. PubMed Europe PubMed DOI I
Yu,Y., Zhao,Y., Fan,Y., Chen,Z., Li,H., Lu,J., Guo,K., Woodfield,S.E., Vasudevan,S.A., Yang,J. and Nuchtern,J.G. Inhibition of ubiquitin-specific protease 14 suppresses cell proliferation and synergizes with chemotherapeutic agents in neuroblastoma Mol Cancer Ther (2019) 18, 1045-1056. PubMed Europe PubMed DOI K I

2018

Ahmed,Z.S.O., Li,X., Li,F., Cheaito,H.A., Patel,K., Mosallam,E.M., Elbargeesy,G.A.E.H. and Dou,Q.P. Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells J Cell Biochem (2018) 119, 9006-9016. PubMed Europe PubMed DOI I
Chakraborty,J., von Stockum,S., Marchesan,E., Caicci,F., Ferrari,V., Rakovic,A., Klein,C., Antonini,A., Bubacco,L. and Ziviani,E. USP14 inhibition corrects an in vivo model of impaired mitophagy EMBO Mol Med (2018) 10, e9014-e9014. PubMed Europe PubMed DOI I
Didier,R., Mallavialle,A., Ben Jouira,R., Domdom,M.A., Tichet,M., Auberger,P., Luciano,F., Ohanna,M., Tartare-Deckert,S. and Deckert,M. Targeting the proteasome-associated deubiquitinating enzyme USP14 impairs melanoma cell survival and overcomes resistance to MAPK-targeting therapies Mol Cancer Ther (2018) 17, 1416-1429. PubMed Europe PubMed DOI
Kim,E., Park,S., Lee,J.H., Mun,J.Y., Choi,W.H., Yun,Y., Lee,J., Kim,J.H., Kang,M.J. and Lee,M.J. Dual function of USP14 deubiquitinase in cellular proteasomal activity and autophagic flux Cell Rep (2018) 24, 732-743. PubMed Europe PubMed DOI
Kim,H.T. and Goldberg,A.L. UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells Proc Natl Acad Sci U S A (2018) 115, E11642-E11642. PubMed Europe PubMed DOI
Lee,J.H., Park,S., Yun,Y., Choi,W.H., Kang,M.J. and Lee,M.J. Inactivation of USP14 perturbs ubiquitin homeostasis and delays the cell cycle in mouse embryonic fibroblasts and in fruit fly Drosophila Cell Physiol Biochem (2018) 47, 67-82. PubMed Europe PubMed DOI M
Liu,B., Jiang,S., Li,M., Xiong,X., Zhu,M., Li,D., Zhao,L., Qian,L., Zhai,L., Li,J., Lu,H., Sun,S., Lin,J., Lu,Y., Li,X. and Tan,M. Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN Nat Commun (2018) 9, 4770-4770. PubMed Europe PubMed DOI PMC EPMC
Liu,Q., Wu,Y., Qin,Y., Hu,J., Xie,W., Qin,F.X. and Cui,J. Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses Sci Adv (2018) 4, eaar2824-eaar2824. PubMed Europe PubMed DOI PMC EPMC
Palmer,A.L., de Jong,A., Leestemaker,Y., Geurink,P.P., Wijdeven,R.H., Ovaa,H. and Dolan,B.P. Inhibition of the deubiquitinase Usp14 diminishes direct MHC class I antigen presentation J Immunol (2018) 200, 928-936. PubMed Europe PubMed DOI
Sharma,A., Alswillah,T., Singh,K., Chatterjee,P., Willard,B., Venere,M., Summers,M.K. and Almasan,A. USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination Autophagy (2018) 14, 1976-1990. PubMed Europe PubMed DOI
Wang,Y., Jiang,Y., Ding,S., Li,J., Song,N., Ren,Y., Hong,D., Wu,C., Li,B., Wang,F., He,W., Wang,J. and Mei,Z. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade Cell Res (2018) 28, 1186-1194. PubMed Europe PubMed DOI I
Yu,F., Liu,J.B., Wu,Z.J., Xie,W.T., Zhong,X.J., Hou,L.K., Wu,W., Lu,H.M., Jiang,X.H., Jiang,J.J., Cao,Z.Y., Cong,G.J., Shi,M.X., Jia,C.Y., Lu,G.X., Song,Y.C., Chai,L., Lv,Z.W., Wu,C.Y., Ma,Y.S. and Fu,D. Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14 Cancer Lett (2018) 427, 74-84. PubMed Europe PubMed DOI

2017

Chen,X., Yang,Q., Xiao,L., Tang,D., Dou,Q.P. and Liu,J. Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents Cancer Metastasis Rev (2017) 36, 655-668. PubMed Europe PubMed DOI I
De Poot,S.A.H., Tian,G. and Finley,D. Meddling with fate: the proteasomal deubiquitinating enzymes J Mol Biol (2017) 429, 3525-3545. PubMed Europe PubMed DOI
Kim,H.T. and Goldberg,A.L. The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis J Biol Chem (2017) 292, 9830-9839. PubMed Europe PubMed DOI
Kuo,C.L. and Goldberg,A.L. Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c Proc Natl Acad Sci U S A (2017) 114, E3404-E3413. PubMed Europe PubMed DOI
Liao,Y., Liu,N., Hua,X., Cai,J., Xia,X., Wang,X., Huang,H. and Liu,J. Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor Cell Death Dis (2017) 8, e2585-e2585. PubMed Europe PubMed DOI
Liu,N., Kong,T., Chen,X., Hu,H., Gu,H., Liu,S., Chen,X., Yang,Q., Li,A., Xiong,X. and Zhang,Z. Ubiquitin-specific protease 14 regulates LPS-induced inflammation by increasing ERK1/2 phosphorylation and NF-kappaB activation Mol Cell Biochem (2017) 431, 87-96. PubMed Europe PubMed DOI
Min,J.W., Lu,L., Freeling,J.L., Martin,D.S. and Wang,H. USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice J Neurochem (2017) 140, 826-833. PubMed Europe PubMed DOI I
Song,C., Ma,R., Yang,X. and Pang,S. The deubiquitinating enzyme USP14 regulates leukemic chemotherapy drugs-induced cell apoptosis by suppressing ubiquitination of Aurora Kinase B Cell Physiol Biochem (2017) 42, 965-973. PubMed Europe PubMed DOI I
Xu,X., Liu,J., Shen,C., Ding,L., Zhong,F., Ouyang,Y., Wang,Y. and He,S. The role of ubiquitin-specific protease 14 (USP14) in cell adhesion-mediated drug resistance (CAM-DR) of multiple myeloma cells Eur J Haematol (2017) 98, 4-12. PubMed Europe PubMed DOI
Yue,X., Zuo,Y., Ke,H., Luo,J., Lou,L., Qin,W., Wang,Y., Liu,Z., Chen,D., Sun,H., Zheng,W., Zhu,C., Wang,R., Wen,G., Du,J., Zhou,B. and Bu,X. Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase Biochem Pharmacol (2017) 137, 29-50. PubMed Europe PubMed DOI I
Zhang,J., Zhang,D. and Sun,L. Knockdown of ubiquitin-specific protease 14 (USP14) inhibits the proliferation and tumorigenesis in esophageal squamous cell carcinoma cells Oncol Res (2017) 25, 249-257. PubMed Europe PubMed DOI K

2016

Flierman,D., van der Heden van Noort,G.J., Ekkebus,R., Geurink,P.P., Mevissen,T.E., Hospenthal,M.K., Komander,D. and Ovaa,H. Non-hydrolyzable diubiquitin probes reveal linkage-specific reactivity of deubiquitylating enzymes mediated by S2 pockets Cell Chem Biol (2016) 23, 472-482. PubMed Europe PubMed DOI
Huang,X., Luan,B., Wu,J. and Shi,Y. An atomic structure of the human 26S proteasome Nat Struct Mol Biol (2016) 23, 778-785. PubMed Europe PubMed DOI S
Lahaie,N., Kralikova,M., Prezeau,L., Blahos,J. and Bouvier,M. Post-endocytotic deubiquitination and degradation of the metabotropic gamma-aminobutyric acid receptor by the ubiquitin-specific protease 14 J Biol Chem (2016) 291, 7156-7170. PubMed Europe PubMed DOI I
Lee,B.H., Lu,Y., Prado,M.A., Shi,Y., Tian,G., Sun,S., Elsasser,S., Gygi,S.P., King,R.W. and Finley,D. USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites Nature (2016) 532, 398-401. PubMed Europe PubMed DOI PMC EPMC
Ortuno,D., Carlisle,H.J. and Miller,S. Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases? F1000Res (2016) 5, 137-137. PubMed Europe PubMed DOI PMC EPMC
Sareen-Khanna,K., Papillon,J., Wing,S.S. and Cybulsky,A.V. Role of the deubiquitinating enzyme ubiquitin-specific protease-14 in proteostasis in renal cells Am J Physiol Renal Physiol (2016) 311, F1035-F1035. PubMed Europe PubMed DOI
Xu,D., Shan,B., Sun,H., Xiao,J., Zhu,K., Xie,X., Li,X., Liang,W., Lu,X., Qian,L. and Yuan,J. USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1 Genes Dev (2016) 30, 1718-1730. PubMed Europe PubMed DOI
Zhao,C., Chen,X., Zang,D., Lan,X., Liao,S., Yang,C., Zhang,P., Wu,J., Li,X., Liu,N., Liao,Y., Huang,H., Shi,X., Jiang,L., Liu,X., He,Z., Dou,Q.P., Wang,X. and Liu,J. A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy Oncogene (2016) 35, 5916-5927. PubMed Europe PubMed DOI I

2015

D'Arcy,P., Wang,X. and Linder,S. Deubiquitinase inhibition as a cancer therapeutic strategy Pharmacol Ther (2015) 147C, 32-54. PubMed Europe PubMed DOI I
Homma,T., Ishibashi,D., Nakagaki,T., Fuse,T., Mori,T., Satoh,K., Atarashi,R. and Nishida,N. Ubiquitin-specific protease 14 modulates degradation of cellular prion protein Sci Rep (2015) 5, 11028-11028. PubMed Europe PubMed DOI PMC EPMC
Huang,G., Li,L. and Zhou,W. USP14 activation promotes tumor progression in hepatocellular carcinoma Oncol Rep (2015) 34, 2917-2924. PubMed Europe PubMed DOI
Lee,J.H., Shin,S.K., Jiang,Y., Choi,W.H., Hong,C., Kim,D.E. and Lee,M.J. Facilitated tau degradation by USP14 aptamers via enhanced proteasome activity Sci Rep (2015) 5, 10757-10757. PubMed Europe PubMed DOI PMC EPMC I
Selvaraju,K., Mazurkiewicz,M., Wang,X., Gullbo,J., Linder,S. and D'Arcy,P. Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors? Drug Resist Updat (2015) 21-22, 20-29. PubMed Europe PubMed DOI
Vaden,J.H., Bhattacharyya,B.J., Chen,P.C., Watson,J.A., Marshall,A.G., Phillips,S.E., Wilson,J.A., King,G.D., Miller,R.J. and Wilson,S.M. Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction Mol Neurodegener (2015) 10, 3-3. PubMed Europe PubMed DOI
Vaden,J.H., Watson,J.A., Howard,A.D., Chen,P.C., Wilson,J.A. and Wilson,S.M. Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14 Front Mol Neurosci (2015) 8, 11- PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Wang,J., Zhong,J., Deng,Y., Xi,Q., He,S., Yang,S., Jiang,L., Huang,M., Tang,C. and Liu,R. Ubiquitin-specific protease 14 (USP14) regulates cellular proliferation and apoptosis in epithelial ovarian cancer Med Oncol (2015) 32, 379-379. PubMed Europe PubMed DOI T
Xu,D., Shan,B., Lee,B.H., Zhu,K., Zhang,T., Sun,H., Liu,M., Shi,L., Liang,W., Qian,L., Xiao,J., Wang,L., Pan,L., Finley,D. and Yuan,J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system elife (2015) 4, e10510-e10510. PubMed Europe PubMed DOI

2014

Jarome,T.J., Kwapis,J.L., Hallengren,J.J., Wilson,S.M. and Helmstetter,F.J. The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation Learn Mem (2014) 21, 9-13. PubMed Europe PubMed DOI
Liu,N., Li,X., Huang,H., Zhao,C., Liao,S., Yang,C., Liu,S., Song,W., Lu,X., Lan,X., Chen,X., Yi,S., Xu,L., Jiang,L., Zhao,C., Dong,X., Zhou,P., Li,S., Wang,S., Shi,X., Dou,P.Q., Wang,X. and Liu,J. Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth Oncotarget (2014) 5, 5453-5471. PubMed Europe PubMed I
Tian,Z., D'Arcy,P., Wang,X., Ray,A., Tai,Y.T., Hu,Y., Carrasco,R.D., Richardson,P., Linder,S., Chauhan,D. and Anderson,K.C. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance Blood (2014) 123, 706-716. PubMed Europe PubMed DOI I

2013

Jung,H., Kim,B.G., Han,W.H., Lee,J.H., Cho,J.Y., Park,W.S., Maurice,M.M., Han,J.K., Lee,M.J., Finley,D. and Jho,E.H. Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling Oncogenesis (2013) 2, e64-e64. PubMed Europe PubMed DOI
Marshall,A.G., Watson,J.A., Hallengren,J.J., Walters,B.J., Dobrunz,L.E., Francillon,L., Wilson,J.A., Phillips,S.E. and Wilson,S.M. Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14) PLoS ONE (2013) 8, e84042-e84042. PubMed Europe PubMed DOI PMC EPMC
Peth,A., Kukushkin,N., Bosse,M. and Goldberg,A.L. Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs J Biol Chem (2013) 288, 7781-7790. PubMed Europe PubMed DOI
Ponnappan,S., Palmieri,M., Sullivan,D.H. and Ponnappan,U. Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging Mech Ageing Dev (2013) 134, 53-59. PubMed Europe PubMed DOI I

2012

Bhattacharyya,B.J., Wilson,S.M., Jung,H. and Miller,R.J. Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14 Am J Physiol Cell Physiol (2012) 302, C698-C708. PubMed Europe PubMed DOI K
Faesen,A.C., Luna-Vargas,M.P. and Sixma,T.K. The role of UBL domains in ubiquitin-specific proteases Biochem Soc Trans (2012) 40, 539-545. PubMed Europe PubMed DOI
Lee,B.H., Finley,D. and King,R.W. A high-throughput screening method for identification of inhibitors of the deubiquitinating enzyme USP14 Curr Protoc Chem Biol (2012) 4, 311-330. PubMed Europe PubMed DOI PMC EPMC I
Perry,J.W., Ahmed,M., Chang,K.O., Donato,N.J., Showalter,H.D. and Wobus,C.E. Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response PLoS Pathog (2012) 8, e1002783-e1002783. PubMed Europe PubMed DOI PMC EPMC I
Ploegh,H. Ubiquitin-specific peptidases 14 and 6 [ISSN:978-0-12-407743-0] (2012) 3, 2086-2089. DOI

2011

D'Arcy,P., Brnjic,S., Olofsson,M.H., Fryknas,M., Lindsten,K., De Cesare,M., Perego,P., Sadeghi,B., Hassan,M., Larsson,R. and Linder,S. Inhibition of proteasome deubiquitinating activity as a new cancer therapy Nat Med (2011) 17, 1636-1640. PubMed Europe PubMed DOI I
Lee,M.J., Lee,B.H., Hanna,J., King,R.W. and Finley,D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes Mol Cell Proteomics (2011) 10, R110-R110. PubMed Europe PubMed DOI P

2010

Lee,B.H., Lee,M.J., Park,S., Oh,D.C., Elsasser,S., Chen,P.C., Gartner,C., Dimova,N., Hanna,J., Gygi,S.P., Wilson,S.M., King,R.W. and Finley,D. Enhancement of proteasome activity by a small-molecule inhibitor of USP14 Nature (2010) 467, 179-184. PubMed Europe PubMed DOI PMC EPMC I

2009

Chen,P.C., Qin,L.N., Li,X.M., Walters,B.J., Wilson,J.A., Mei,L. and Wilson,S.M. The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions J Neurosci (2009) 29, 10909-10919. PubMed Europe PubMed DOI PMC EPMC
Mines,M.A., Goodwin,J.S., Limbird,L.E., Cui,F.F. and Fan,G.H. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation J Biol Chem (2009) 284, 5742-5752. PubMed Europe PubMed DOI PMC EPMC
Nagai,A., Kadowaki,H., Maruyama,T., Takeda,K., Nishitoh,H. and Ichijo,H. USP14 inhibits ER-associated degradation via interaction with IRE1alpha Biochem Biophys Res Commun (2009) 379, 995-1000. PubMed Europe PubMed DOI
Peth,A., Besche,H.C. and Goldberg,A.L. Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening Mol Cell (2009) 36, 794-804. PubMed Europe PubMed DOI
Siefke,C., Loebrich,S., Hevers,W., Waidmann,O.B., Schweizer,M., Fehr,S., Fritschy,J.M., Dikic,I., Eilers,J., Wilson,S.M. and Kneussel,M. The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice PLoS Genet (2009) 5, e1000631-e1000631. PubMed Europe PubMed DOI M

2008

Koulich,E., Li,X. and DeMartino,G.N. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome Mol Biol Cell (2008) 19, 1072-1082. PubMed Europe PubMed DOI PMC EPMC
Walters,B.J., Campbell,S.L., Chen,P.C., Taylor,A.P., Schroeder,D.G., Dobrunz,L.E., Artavanis-Tsakonas,K., Ploegh,H.L., Wilson,J.A., Cox,G.A. and Wilson,S.M. Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity Mol Cell Neurosci (2008) 39, 539-548. PubMed Europe PubMed DOI PMC EPMC M

2007

Catic,A., Fiebiger,E., Korbel,G.A., Blom,D., Galardy,P.J. and Ploegh,H.L. Screen for ISG15-crossreactive deubiquitinases PLoS ONE (2007) 2, e679-e679. PubMed Europe PubMed DOI PMC EPMC

2006

[YEAR:1-11-2006]Crimmins,S., Jin,Y., Wheeler,C., Huffman,A.K., Chapman,C., Dobrunz,L.E., Levey,A., Roth,K.A., Wilson,J.A. and Wilson,S.M. Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14 J Neurosci (1-11-2006) 26, 11423-11431. PubMed Europe PubMed DOI M U
Shinji,S., Naito,Z., Ishiwata,S., Ishiwata,T., Tanaka,N., Furukawa,K., Suzuki,H., Seya,T., Matsuda,A., Katsuta,M. and Tajiri,T. Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases Oncol Rep (2006) 15, 539-543. PubMed Europe PubMed

2005

[YEAR:27-9-2005]Anderson,C., Crimmins,S., Wilson,J.A., Korbel,G.A., Ploegh,H.L. and Wilson,S.M. Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice J Neurochem (27-9-2005) 95, 724-731. PubMed Europe PubMed DOI
[YEAR:6-10-2005]Hu,M., Li,P., Song,L., Jeffrey,P.D., Chenova,T.A., Wilkinson,K.D., Cohen,R.E. and Shi,Y. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14 EMBO J (6-10-2005) 24, 3747-3756. PubMed Europe PubMed DOI PMC EPMC S I

2002

Wilson,S.M., Bhattacharyya,B., Rachel,R.A., Coppola,V., Tessarollo,L., Householder,D.B., Fletcher,C.F., Miller,R.J., Copeland,N.G. and Jenkins,N.A. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease Nat Genet (2002) 32, 420-425. PubMed Europe PubMed DOI

2001

[YEAR:17-9-2001]Borodovsky,A., Kessler,B.M., Casagrande,R., Overkleeft,H.S., Wilkinson,K.D. and Ploegh,H.L. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 EMBO J (17-9-2001) 20, 5187-5196. PubMed Europe PubMed DOI PMC EPMC I

1996

[YEAR:1-2-1996]Deshpande,K.L., Seubert,P.H., Tillman,D.M., Farkas,W.R. and Katze,J.R. Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit Arch Biochem Biophys (1-2-1996) 326, 1-7. PubMed Europe PubMed DOI