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Literature for peptidase C19.015: ubiquitin-specific peptidase 14

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hao,X. and Liu,Y.
    Ubiquitin-specific peptidase 14 promotes neuron injury by stabilizing acyl-CoA synthetase long-chain family member 4 through deubiquitination
    Cytojournal22, 11-11. PubMed  Europe PubMed DOI  K
  2. Jha,S., Pispa,J. and Holmberg,C.I.
    Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy
    Biol Open14, PubMed  Europe PubMed DOI  K
  3. Kang,S.W., Park,J.E., Ok,S., Um,M., Son,H., Byun,S., Park,N., Lee,S.J., Tran,T.X.T., Kim,G., Yeom,J., Kim,K., Kim,E.Y. and Kang,M.J.
    Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB
    Commun Biol8, 191-191. PubMed  Europe PubMed DOI  K
  4. Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C.
    Recent advances in small molecule inhibitors of deubiquitinating enzymes
    Eur J Med Chem287, 117324-117324. PubMed  Europe PubMed DOI  V
  5. Qian,J., Zhao,Z., Ma,L., Liu,W. and Song,Y.
    USP14 targets FABP5-mediated ferroptosis to promote proliferation and cisplatin resistance of HNSCC
    Clin Transl Oncol PubMed  Europe PubMed DOI
  6. Qian,Y., Wu,J., Yang,W., Lyu,R., You,Q., Li,J., He,Q., Zhuang,Y., Wang,W., Wang,Y., Zhu,Y., Wu,Z. and Chen,D.
    FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway
    Nat Commun16, 1519-1519. PubMed  Europe PubMed DOI
  7. Salomonsson,J., Sjostrand,L., Eskilson,A., Derbyshire,D., D'Arcy,P., Sunnerhagen,M. and Ahlner,A.
    Dynamic networks connect the USP14 active site region with the proteasome interaction surface
    Protein Sci34, e70077-e70077. PubMed  Europe PubMed DOI
  8. Srinivasan,V., Soliymani,R., Ivanova,L., Eriksson,O., Peitsaro,N., Lalowski,M., Karelson,M. and Lindholm,D.
    USP14 is crucial for proteostasis regulation and alpha-synuclein degradation in human SH-SY5Y dopaminergic cells
    Heliyon11, e42031-e42031. PubMed  Europe PubMed DOI
  9. Wang,Z., Yu,C., Xie,G., Tao,K., Yin,Z. and Lv,Q.
    USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer
    Mol Med31, 163-163. PubMed  Europe PubMed DOI  K
  10. You,L., Wang,Q., Zhang,T., Xiao,H., Lv,M., Lv,H., Deng,L., Zhang,X. and Zhang,Y.
    USP14-IMP2-CXCL2 axis in tumor-associated macrophages facilitates resistance to anti-PD-1 therapy in gastric cancer by recruiting myeloid-derived suppressor cells
    Oncogene PubMed  Europe PubMed DOI
  11. Yu,L., Zheng,X., Wu,Y. and Ge,K.
    USP14-Dependent IGF1R Aggravates High Glucose-Induced Diabetic Retinopathy by Upregulating BAP1
    Appl Biochem Biotechnol PubMed  Europe PubMed DOI
  12. Zhang,A., Zhang,H., Liu,L., Zhang,H., Mo,L., Zhang,W., Harith,H.H., Cheng,L., Lv,J., Tham,C.L. and Yang,P.
    USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy
    Cell Immunol411-412, 104943-104943. PubMed  Europe PubMed DOI
  13. Zhang,Y., Zhou,L., Fu,Q. and Liu,Z.
    FOXG1 promotes osteogenesis of bone marrow-derived mesenchymal stem cells by activating autophagy through regulating USP14
    Commun Biol8, 59-59. PubMed  Europe PubMed DOI  K
  14. Zhao,Q., Wang,X., Zhang,T., Guo,S., Liu,X., Wan,S., Guo,Y., Zhang,Q., Li,J., Wang,S. and Dong,L.
    Piceatannol upregulates USP14-mediated GPX4 deubiquitination to inhibit neuronal ferroptosis caused by cerebral ischemia-reperfusion in mice
    Food Chem Toxicol197, 115281-115281. PubMed  Europe PubMed DOI  K
  15. Zhou,X., Xia,Q., Wang,B., Li,J., Liu,B., Wang,S., Huang,M., Zhong,R., Cheng,S.Y., Wang,X., Jiang,X. and Huang,T.
    USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5
    Theranostics15, 2293-2314. PubMed  Europe PubMed DOI
    16. 2024
  16. Alhasan,B.A., Morozov,A.V., Guzhova,I.V. and Margulis,B.A.
    The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence
    Biochim Biophys Acta Rev Cancer1879, 189119-189119. PubMed  Europe PubMed DOI  V
  17. Ba,L., E,M., Wang,R., Wu,N., Wang,R., Liu,R., Feng,X., Qi,H., Sun,H. and Qiao,G.
    Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway
    Heliyon10, e24010-e24010. PubMed  Europe PubMed DOI  K
  18. Bai,T., Mai,R.Y., Tang,Z.H., Wang,X.B., Chen,J., Ye,J.Z., Wei,M., Zhang,B., Li,K., Gu,Z.M., Wu,F.X. and Li,L.Q.
    Ubiquitination of P53 Regulated by Ubiquitin-Specific Protease 14 Delays the Invasion of Hepatitis B Virus and the Development of Hepatitis
    Viral Immunol37, 432-439. PubMed  Europe PubMed DOI
  19. Bian,J., Ge,W. and Jiang,Z.
    miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-kappaB Signaling Pathway
    J Ophthalmol2024, 1470898-1470898. PubMed  Europe PubMed DOI  K
  20. Chen,Y., Feng,Y., Lin,Y., Zhou,X., Wang,L., Zhou,Y., Lin,K. and Cai,L.
    GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4
    Br J Cancer130, 755-768. PubMed  Europe PubMed DOI
  21. Dash,R., Tran,N.N., Lee,S.B. and Lee,B.H.
    Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation
    Cells13, PubMed  Europe PubMed DOI
  22. Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M., Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P.
    Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in Parkinson's disease
    Cell Mol Life Sci81, 232-232. PubMed  Europe PubMed DOI  K
  23. Favaro,M., Mauri,S., Bernardo,G., Zordan,M.A., Mazzotta,G.M. and Ziviani,E.
    Usp14 down-regulation corrects sleep and circadian dysfunction of a Drosophila model of Parkinson's disease
    Front Neurosci18, 1410139-1410139. PubMed  Europe PubMed DOI
  24. Gao,J. and Gao,Z.
    The regulatory role and mechanism of USP14 in endothelial cell pyroptosis induced by coronary heart disease
    Clin Hemorheol Microcirc86, 495-508. PubMed  Europe PubMed DOI
  25. Greta,B., Prado Miguel,A., Roshani,D.A., Favaro,M., Mauri,S., Borsetto,A., Marchesan,E., Paulo,J.A., Gygi,S.P., Finley,D.J. and Ziviani,E.
    USP14 inhibition enhances Parkin-independent mitophagy in iNeurons
    Pharmacol Res107484-107484. PubMed  Europe PubMed DOI
  26. Gubat,J., Sjostrand,L., Selvaraju,K., Telli,K. and D'Arcy,P.
    Loss of the proteasomal deubiquitinase USP14 induces growth defects and a senescence phenotype in colorectal cancer cells
    Sci Rep14, 13037-13037. PubMed  Europe PubMed DOI
  27. Kim,H., Kim,H., Lee,S.H., Kwon,J.H., Byun,S., Yoo,J.Y., Park,S.Y. and Yoon,H.G.
    Deubiquitinase inhibitor bAP-15 suppresses renal epithelial to mesenchymal transition via inhibition of p300 stability
    Biochem Biophys Res Commun741, 151095-151095. PubMed  Europe PubMed DOI  I
  28. Lei,K., Liang,R., Liang,J., Lu,N., Huang,J., Xu,K., Tan,B., Wang,K., Liang,Y., Wang,W., Lin,H. and Wang,M.
    CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
    J Exp Clin Cancer Res43, 124-124. PubMed  Europe PubMed DOI
  29. Li,G., Zhou,C., Wang,L., Zheng,Y., Zhou,B., Li,G., Ma,Z., Sun,P., Deng,Y., Su,L., Wang,J. and Cui,H.
    MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14
    Pigment Cell Melanoma Res37, 316-328. PubMed  Europe PubMed DOI  I
  30. Li,M., Zhao,Y., Zhang,J., Jiang,W., Peng,S., Hu,J. and Shen,Y.
    Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro
    Eur J Histochem68, PubMed  Europe PubMed DOI
  31. Li,P., Zhu,X., Qu,H., Han,Z., Yao,X., Wei,Y., Li,B. and Chen,H.
    Synergistic Effect of Ubiquitin-Specific Protease 14 and Poly(ADP-Ribose) Glycohydrolase Co-Inhibition in BRCA1-Mutant, Poly(ADP-Ribose) Polymerase Inhibitor-Resistant Triple-Negative Breast Cancer Cells
    Onco Targets Ther17, 741-753. PubMed  Europe PubMed DOI
  32. Li,Y., Dong,B., Wang,Y., Bi,H., Zhang,J., Ding,C., Wang,C., Ding,X. and Xue,W.
    Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy
    Transl Res270, 94-103. PubMed  Europe PubMed DOI  K
  33. Liu,D., Li,M., Zhao,Z., Zhou,L., Zhi,F., Guo,Z. and Cui,J.
    Targeting the TRIM14/USP14 Axis Enhances Immunotherapy Efficacy by Inducing Autophagic Degradation of PD-L1
    Cancer Res84, 2806-2819. PubMed  Europe PubMed DOI
  34. Liu,Y., Xun,W., Zhao,T., Huang,M., Sun,L., Wen,G., Kang,X., Wang,J. and Han,T.
    Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma
    Commun Biol7, 1365-1365. PubMed  Europe PubMed DOI
  35. Ma,L.Z., Wang,A., Lai,Y.H., Zhang,J., Zhang,X.F., Chen,S.L. and Zhou,X.Y.
    USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency
    J Transl Med22, 834-834. PubMed  Europe PubMed DOI  I
  36. Nogami,A., Amemiya,H.J., Fujiwara,H., Umezawa,Y., Tohda,S. and Nagao,T.
    Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML
    Int J Mol Sci25, PubMed  Europe PubMed DOI  K  I
  37. Olie,C.S., O'Brien,D.P., Jones,H.B.L., Liang,Z., Damianou,A., Sur-Erdem,I., Pinto-Fernandez,A., Raz,V. and Kessler,B.M.
    Deubiquitinases in muscle physiology and disorders
    Biochem Soc Trans52, 1085-1098. PubMed  Europe PubMed DOI  V
  38. Rong,Q., Xi,Z., Guo,D., Xu,W., Zhang,L. and Wu,Q.
    Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 in Drosophila
    J Virole0017724-e0017724. PubMed  Europe PubMed DOI
  39. Song,H., Qiu,J. and Hua,K.
    USP14 promotes the proliferation of cervical cancer via upregulating beta-catenin
    Environ Toxicol39, 1031-1043. PubMed  Europe PubMed DOI  K
  40. Wang,C., Fu,W., Zhang,Y., Hu,X., Xu,Q. and Tong,X.
    C-MYC-activated lncRNA SNHG20 accelerates the proliferation of diffuse large B cell lymphoma via USP14-mediated deubiquitination of beta-catenin
    Biol Direct19, 47-47. PubMed  Europe PubMed DOI  K
  41. Wei,D., Tian,X., Ren,Z., Liu,Z. and Sun,C.
    Mechanistic insights into the role of USP14 in adipose tissue macrophage recruitment and insulin resistance in obesity
    Int J Biol Macromol267, 131645-131645. PubMed  Europe PubMed DOI  K
  42. Xia,X., Liu,X., Xu,Q., Gu,J., Ling,S., Liu,Y., Li,R., Zou,M., Jiang,S., Gao,Z., Chen,C., Liu,S. and Liu,N.
    USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein
    Cell Death Discov10, 295-295. PubMed  Europe PubMed DOI
  43. Xu,M.H., Zheng,Y.M., Liang,B.G., Xu,W.X., Cao,J., Wang,P., Dong,Z.Y., Zhou,C.H., Sun,H.C., Ren,N., Ke,A.W. and Shen,Y.H.
    Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma
    Int J Biol Sci20, 3269-3284. PubMed  Europe PubMed DOI  K
  44. Yang,C., Shu,J., Yang,X., Miao,Y., Liu,J., Li,J., Xiao,J., Kong,W., Xu,Z. and Feng,H.
    USP14 negatively regulates IFN signaling by dampening K63-linked ubiquitination of TBK1 in black carp
    Fish Shellfish Immunol149, 109559-109559. PubMed  Europe PubMed DOI
  45. Yuan,F., Xu,J., Xuan,L., Deng,C., Wang,W. and Yang,R.
    USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer
    Neoplasia60, 101101-101101. PubMed  Europe PubMed DOI  K
  46. Zhang,N., Zhang,H., Yang,X., Xue,Q., Wang,Q., Chang,R., Zhu,L., Chen,Z. and Liu,X.
    USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axis
    BMC Cancer24, 237-237. PubMed  Europe PubMed DOI
  47. Zhang,X., Geng,L., Tang,Y., Wang,Y., Zhang,Y., Zhu,C., Lei,H., Xu,H., Zhu,Q., Wu,Y. and Gu,W.
    Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma
    J Transl Med22, 193-193. PubMed  Europe PubMed DOI
  48. Zhang,Z., Jin,B., Zhang,Y., Yang,M., Wang,C., Zhu,Y., Li,T., Lin,J., Yang,M., Cheng,Y., Xu,S., He,K., Xu,J., Mi,Y., Jiang,J. and Sun,Z.
    USP14 modulates cell pyroptosis and ameliorates doxorubicin-induced cardiotoxicity by deubiquitinating and stabilizing SIRT3
    Free Radic Biol Med225, 741-757. PubMed  Europe PubMed DOI  K
  49. Zhang,Z., Guo,Q., Ma,C., Zhao,Z., Shi,Q., Yu,H., Rao,L. and Li,M.
    USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis
    Mol Med30, 32-32. PubMed  Europe PubMed DOI  K
    50. 2023
  50. Cui,Y., Luo,L., Zeng,Z., Liu,X., Li,T., He,X., Ma,Y., Meng,W., Zeng,H., Long,Y., Zong,D. and Chen,Y.
    MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells
    Cell Death Dis14, 2-2. PubMed  Europe PubMed DOI
  51. Ding,W., Wang,J.X., Wu,J.Z., Liu,A.C., Jiang,L.L., Zhang,H.C., Meng,Y., Liu,B.Y., Peng,G.J., Lou,E.Z., Mao,Q., Zhou,H., Tang,D.L., Chen,X., Liu,J.B. and Shi,X.P.
    Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells
    Acta Pharmacol Sin44, 2537-2548. PubMed  Europe PubMed DOI
  52. Du,X.H., Ke,S.B., Liang,X.Y., Gao,J., Xie,X.X., Qi,L.Z., Liu,X.Y., Xu,G.Y., Zhang,X.D., Du,R.L. and Li,S.Z.
    USP14 promotes colorectal cancer progression by targeting JNK for stabilization
    Cell Death Dis14, 56-56. PubMed  Europe PubMed DOI
  53. Fu,Y., Qiu,J., Wu,J., Zhang,L., Wei,F., Lu,L., Wang,C., Zeng,Z., Liang,S. and Zheng,J.
    USP14-mediated NLRC5 upregulation inhibits endothelial cell activation and inflammation in atherosclerosis
    Biochim Biophys Acta Mol Cell Biol Lipids1868, 159258-159258. PubMed  Europe PubMed DOI
  54. Ge,J., Wang,Y., Chen,X., Yu,K., Luo,Z.Q., Liu,X. and Qiu,J.
    Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome
    Cell Rep42, 112817-112817. PubMed  Europe PubMed DOI
  55. Gong,X., Jia,L., Zhou,L. and Hu,T.
    USP14 predicts poorer survival outcomes and promotes tumor progression in endometrial carcinoma by activating NF-kappaB signaling
    Aging (Albany NY)15, 12120-12135. PubMed  Europe PubMed DOI  K
  56. He,F., Chen,Y., He,D. and He,S.
    USP14-mediated deubiquitination of SIRT1 in macrophage promotes fatty acid oxidation amplification and M2 phenotype polarization
    Biochem Biophys Res Commun646, 19-29. PubMed  Europe PubMed DOI
  57. Ji,J., Lv,J., Lv,M., Jing,A., Xu,M., Yuan,Q., Ma,X., Qian,Q., Wang,W., Geng,T., Ding,Y., Qin,J., Liu,Y., Yang,J., Zhou,J., Ma,L., Wang,Y., Zuo,L., Wang,X., Ma,S. and Liu,B.
    USP14 regulates heme metabolism and ovarian cancer invasion through BACH1 deubiquitination and stabilization
    Biochem Biophys Res Commun667, 186-193. PubMed  Europe PubMed DOI  K
  58. Jin,S., Tsunematsu,T., Horiguchi,T., Mouri,Y., Shao,W., Miyoshi,K., Hagita,H., Sarubo,M., Fujiwara,N., Qi,G., Ishimaru,N. and Kudo,Y.
    Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma
    Cancer Med12, 22156-22169. PubMed  Europe PubMed DOI
  59. Lee,M.Y., Kim,M.J., Jin,J.O. and Lee,P.C.
    USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer
    BMB Rep56, 451-456. PubMed  Europe PubMed DOI  K
  60. Lin,C., Li,L., Xu,Q., Xu,S. and Tang,C.
    Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse
    Mol Neurobiol60, 4273-4287. PubMed  Europe PubMed DOI
  61. Morgan,E.L., Toni,T., Viswanathan,R., Robbins,Y., Yang,X., Cheng,H., Gunti,S., Huynh,A., Sowers,A.L., Mitchell,J.B., Allen,C.T., Chen,Z. and Van Waes,C.
    Inhibition of USP14 promotes TNFalpha-induced cell death in head and neck squamous cell carcinoma (HNSCC)
    Cell Death Differ30, 1382-1396. PubMed  Europe PubMed DOI
  62. Morrow,N.M. and Mulvihill,E.E.
    Complexity in Hepatic Insulin Resistance - Unraveling the Role of Ubiquitin-Specific Protease 14 in Protein Homeostasis of Metabolic Transcription Factors
    J Pharmacol Exp Ther385, 1-4. PubMed  Europe PubMed DOI
  63. Su,Y., Zeng,K., Liu,S., Wu,Y., Wang,C., Wang,S., Lin,L., Zou,R., Sun,G., Luan,R., Zhou,B., Bai,Y., Niu,J., Zhang,Y. and Zhao,Y.
    Ubiquitin-specific peptidase 14 maintains estrogen receptor alpha stability via its deubiquitination activity in endometrial cancer
    J Biol Chem299, 102734-102734. PubMed  Europe PubMed DOI  K
  64. Wang,J., Xiang,Y., Xie,Z., Fan,M., Fang,S., Wan,H., Zhao,R., Zeng,F. and Hua,Q.
    USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization
    Cancers (Basel)15, PubMed  Europe PubMed DOI
  65. Wei,D., Tian,X., Zhu,L., Wang,H. and Sun,C.
    USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1
    Cell Death Dis14, 566-566. PubMed  Europe PubMed DOI  K
  66. Wu,J., Pang,X., Yang,X., Zhang,M., Chen,B., Fan,H., Wang,H., Yu,X., Tang,Y. and Liang,X.
    M1 macrophages induce PD-L1(hi) cell-led collective invasion in HPV-positive head and neck squamous cell carcinoma via TNF-alpha/CDK4/UPS14
    J Immunother Cancer11, PubMed  Europe PubMed DOI
  67. Xiang,J., Zhang,N., Du,A., Li,J., Luo,M., Wang,Y., Liu,M., Yang,L., Li,X., Wang,L., Liu,Q., Chen,D., Wang,T., Bian,X.W., Qin,Z.Y., Su,L., Wen,L. and Wang,B.
    A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer
    Adv Sci (Weinh)10, e2305550-e2305550. PubMed  Europe PubMed DOI
  68. Zhang,Y., Lu,P., Jin,S., Zhang,J. and Zhou,Y.
    USP14 promotes the malignant progression and ibrutinib resistance of mantle cell lymphoma by stabilizing XPO1
    Int J Med Sci20, 616-626. PubMed  Europe PubMed DOI
    69. 2022
  69. Hai,B., Mao,T., Du,C., Jia,F., Liu,Y., Song,Q., Pan,X., Liu,X. and Zhu,B.
    USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3
    Acta Biochim Biophys Sin (Shanghai)54, 1-11. PubMed  Europe PubMed DOI  K
  70. Jiang,L., He,Q., Chen,X., Liu,A., Ding,W., Zhang,H., Chen,X., Zhou,H., Meng,Y., Liu,B., Peng,G., Wang,C., Liu,J. and Shi,X.
    Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia
    Clin Transl Med12, e1038-e1038. PubMed  Europe PubMed DOI  I
  71. Jiang,Z.Y., Hong,J., Zhang,J.H., Wang,X.F., Ma,Y.S., Xiong,Z.X., Sun,H.R., Cheng,C., Xie,B.Z., Liu,J.B., Ouyang,Y.G. and Fu,D.
    Treatment with b-AP15 to Inhibit UCHL5 and USP14 Deubiquitinating Activity and Enhance p27 and Cyclin E1 for Tumors with p53 Deficiency
    Technol Cancer Res Treat21, 15330338221119745-15330338221119745. PubMed  Europe PubMed DOI  I
  72. Liu,D., Zhao,Z., She,Y., Zhang,L., Chen,X., Ma,L. and Cui,J.
    TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation
    Proc Natl Acad Sci U S A119, PubMed  Europe PubMed DOI
  73. Shi,D., Wu,X., Jian,Y., Wang,J., Huang,C., Mo,S., Li,Y., Li,F., Zhang,C., Zhang,D., Zhang,H., Huang,H., Chen,X., Wang,Y.A., Lin,C., Liu,G., Song,L. and Liao,W.
    USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
    Nat Commun13, 5644-5644. PubMed  Europe PubMed DOI
  74. van der Wal,L., Bezstarosti,K. and Demmers,J.A.A.
    A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37
    J Proteomics262, 104592-104592. PubMed  Europe PubMed DOI  I
  75. Wang,D., Jin,X., Lei,M., Jiang,Y., Liu,Y., Yu,F., Guo,Y., Han,B., Yang,Y., Sun,W., Liu,Y., Zeng,G., Liu,F., Hu,J. and Chen,X.
    USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling
    Int J Biol Sci18, 2452-2471. PubMed  Europe PubMed DOI  K
  76. Wu,T., Li,C., Zhou,C., Niu,X., Li,G., Zhou,Y., Gu,X. and Cui,H.
    Inhibition of USP14 enhances anti-tumor effect in vemurafenib-resistant melanoma by regulation of Skp2
    Cell Biol Toxicol PubMed  Europe PubMed DOI  K
  77. Zhang,B., Zhang,M., Yang,Y., Li,Q., Yu,J., Zhu,S., Niu,Y. and Shang,Z.
    Targeting KDM4A-AS1 represses AR/AR-Vs deubiquitination and enhances enzalutamide response in CRPC
    Oncogene41, 387-399. PubMed  Europe PubMed DOI  K
  78. Zhang,S., Zou,S., Yin,D., Zhao,L., Finley,D., Wu,Z. and Mao,Y.
    USP14-regulated allostery of the human proteasome by time-resolved cryo-EM
    Nature605, 567-574. PubMed  Europe PubMed DOI
    79. 2021
  79. Hang,C., Gong,C., Fang,Y., Chen,L. and Zhu,J.
    Ubiquitin-specific protease 14 (USP14) promotes proliferation and metastasis in pancreatic ductal adenocarcinoma
    J Mol Histol PubMed  Europe PubMed DOI  K
  80. Huang,C., Cao,H., Qin,J., Xu,L., Hu,F., Gu,Y., Dou,C. and Zhang,S.
    Ubiquitin-Specific Protease 14 (USP14) Aggravates Inflammatory Response and Apoptosis of Lung Epithelial Cells in Pneumonia by Modulating Poly (ADP-Ribose) Polymerase-1 (PARP-1)
    Inflammation PubMed  Europe PubMed DOI
  81. Li,H., Quan,J., Zhao,X., Ling,J. and Chen,W.
    USP14 negatively regulates RIG-I-mediated IL-6 and TNF-alpha production by inhibiting NF-kappaB activation
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