$VAR1 = undef;

Summary for peptidase C19.015: ubiquitin-specific peptidase 14

Names
MEROPS Name	ubiquitin-specific peptidase 14
Other names	TGT subunit, tRNA-guanine transglycosylase 60-kDa subunit, USP14 g.p. (Homo sapiens), USP14, ubiquitin-specific protease 14

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C19 >> Subfamily (none) >> C19.015
Holotype	ubiquitin-specific peptidase 14 (Homo sapiens), Uniprot accession P54578 (peptidase unit: 73-494), MERNUM MER0002667
History	Identifier created: MEROPS 3.1 (22 December 1998)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Wilson et al., 2002) mouse: putative
Physiology	There is evidence that ubiquitin-specific peptidase 14 functions to maintain the levels of monomeric ubiquitin in mammalian cells (Anderson et al., 2005).
Knockout	Mutation in mice is reported to account for hereditary ataxia (Wilson et al., 2002). The ataxia (ax(J)) mutation is a spontaneous recessive mutation that results in reduced expression of ubiquitin-specific protease 14. Mice homozygous for the ax(J) mutation are retarded in growth and exhibit several behavioral disorders, including a resting tremor and hindlimb paralysis (Anderson et al., 2005).
Other databases	TREEFAM	http://www.treefam.org/family/TF314494