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Literature for peptidase C19.010: ubiquitin-specific peptidase 4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, R Splicing, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Jiang,X., Wang,Y., Zhang,X., Deng,H., Fang,L., Tafadzwa,C., Yao,J., Chen,H., Ye,A., Zhou,K., Ling,X. and Xiao,J.<br>Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival<br>Clin Transl Med (2026) 16, e70565-e70565. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Chen,S., Yang,J., Qi,G., Zhao,J., Chen,Y., Guo,X., Zhang,J., Gan,J., Jian,Z. and Jin,J.<br>Evodiamine inhibits colorectal cancer cell stemness by disturbing ubiquitin specific protease 4 mediated SOX9 stabilization<br>Discov Oncol (2025) 16, 403-403. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Li,F., Zhou,Y., Lin,X., Zhang,Y., Hu,Q., Zhao,E., Li,H., Pan,X., Shu,F., Zhang,K., Huang,C., Tang,N. and Liao,W.<br>A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting beta-catenin and Twist1 degradation<br>J Transl Med (2025) 23, 114-114. PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Liu,Z., Li,X., He,Y., Xie,F., Zhang,Y., Huang,M., Wang,Y. and Zhu,W.<br>A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade<br>J Orthop Surg Res (2025) 20, 220-220. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Park,T., Forbush,K., Li,Y., Vivas,O., Rosenthal,K.J., Falcone,J., Wong,C.J., Bruce,J.E., Moreno,C., Dessauer,C.W. and Scott,J.D.<br>Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum<br>J Biol Chem (2025) , 110317-110317. PubMed  Europe PubMed DOI
  6. Tu,Y., Xu,L., Fu,G., Wang,J., Xia,P., Tao,Z., Ye,Y., Hu,J., Cai,W., Zhu,H., Wu,Q. and Ji,J.<br>Lactylation-driven USP4-mediated ANXA2 stabilization and activation promotes maintenance and radioresistance of glioblastoma stem cells<br>Cell Death Differ (2025) PubMed  Europe PubMed DOI
  7. Xie,Z., Lin,H., Wu,Y., Yu,Y., Liu,X., Zheng,Y., Wang,X., Wu,J., Xu,M., Han,Y., Zhang,Q., Deng,Y., Lin,L., Linzhu,Y., Qingyun,L., Lin,X., Huang,Y. and Chi,P.<br>USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer<br>Cell Death Dis (2025) 16, 81-81. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Zhang,J., Allen,J., Ward,S.J., Dekker,L.V. and Dreveny,I.<br>A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)<br>J Biol Chem (2025) , 110342-110342. PubMed  Europe PubMed DOI  I
  9. Zhao,X., Lu,S., Xiang,Z., Yan,M., Zhu,Z.G., Dong,F. and Yan,C.<br>USP4-Mediated deubiquitination of A2AR suppresses autophagy-dependent ferroptosis in gastric cancer<br>Cell Mol Life Sci (2025) 82, 342-342. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zhou,S., Li,Y., Wang,C., Zhao,Y. and Zheng,X.<br>K11- and K29-ubiquitination-mediated nuclear translocation of glycolytic enzyme aldolase A promotes pancreatic cancer progression by NF-kappaB activation<br>Cell Death Differ (2025) PubMed  Europe PubMed DOI
    11. 2024
  11. Chu,F., Hou,P., Zhu,H., Gao,Y., Wang,X., He,W., Ren,J., Li,M., Liu,Y., Chang He,D., Wang,H., Gao,Y. and He,H.<br>PBLD enhances antiviral innate immunity by promoting the p53-USP4-MAVS signaling axis<br>Proc Natl Acad Sci U S A (2024) 121, e2401174121-e2401174121. PubMed  Europe PubMed DOI
  12. Guo,X., Ma,Y., Zhang,T., Liu,R., Chang,F., Yan,X., Yu,T., Wu,P., Li,Q., Xu,L., Duan,J., Li,L., Su,Y. and Shao,G.<br>The deubiquitinating enzyme USP4 regulates BRCA1 stability and function<br>NPJ Breast Cancer (2024) 10, 35-35. PubMed  Europe PubMed DOI  PMC  EPMC  K
  13. Hu,C., Zhang,W., Jia,Y., Zhao,J., Chen,Q., Hao,C. and Yu,Y.<br>USP4 promotes PTC progression by stabilizing LDHA and activating the MAPK and AKT signaling pathway<br>Aging (Albany NY) (2024) null PubMed  Europe PubMed DOI
  14. Kang,S., Liu,S., Dong,X., Li,H., Qian,Y., Dai,A., He,W., Li,X., Chen,Q., Wang,H. and Ding,P.H.<br>USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis<br>Autophagy (2024) , 1-18. PubMed  Europe PubMed DOI  K
  15. Kim,J., Taketomi,T., Yamada,A., Uematsu,Y., Ueda,K., Chiba,T. and Tsuruta,F.<br>USP4 regulates TUT1 ubiquitination status in concert with SART3<br>Biochem Biophys Res Commun (2024) 701, 149557-149557. PubMed  Europe PubMed DOI
  16. Li,X., Yan,C., Yun,J., Xu,X., Wei,H., Xu,X., Li,Y. and Yi,J.<br>USP4/CARM1 Axis Promotes the Malignant Transformation of Breast Cancer Cells by Upregulating SLC7A11 Expression<br>Clin Breast Cancer (2024) PubMed  Europe PubMed DOI
  17. Liu,B., Zhang,X., Zhou,Y., Liu,H., Wang,Z., Fu,Y., Gao,Q., Cheng,X., Sun,Q. and Ju,Z.<br>USP4 regulates ribosome biogenesis and protein synthesis for hematopoietic stem cell regeneration and leukemia progression<br>Leukemia (2024) 38, 2466-2478. PubMed  Europe PubMed DOI
  18. Mao,M., Xia,Q., Zhan,G., Bing,H., Zhang,C., Wang,J., Tian,W., Lian,H., Li,X. and Chu,Q.<br>Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination<br>Phytomedicine (2024) 124, 155304-155304. PubMed  Europe PubMed DOI  I
  19. Wu,X., Hong,J. and Hong,L.<br>The Deubiquitinating Enzyme USP4 Promotes Trophoblast Dysfunction by Stabilizing RYBP<br>Cell Biochem Biophys (2024) PubMed  Europe PubMed DOI
  20. Zhou,Y., Li,H., Zhang,Y., Zhao,E., Huang,C., Pan,X., Shu,F., Liu,Z., Tang,N., Li,F. and Liao,W.<br>Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer<br>Cancer Lett (2024) 589, 216836-216836. PubMed  Europe PubMed DOI
    21. 2023
  21. Chen,Y., Guo,Y., Yuan,M., Guo,S., Cui,S. and Chen,D.<br>USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2<br>PLoS ONE (2023) 18, e0290688-e0290688. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Zhang,D.G., Kunz,W.S., Lei,X.J., Zito,E., Zhao,T., Xu,Y.C., Wei,X.L., Lv,W.H. and Luo,Z.<br>Selenium Ameliorated Oxidized Fish Oil-Induced Lipotoxicity via the Inhibition of Mitochondrial Oxidative Stress, Remodeling of Usp4-Mediated Deubiquitination, and Stabilization of Pparalpha<br>Antioxid Redox Signal (2023) PubMed  Europe PubMed DOI  K
  23. Zhang,H., Han,Y., Xiao,W., Gao,Y., Sui,Z., Ren,P., Meng,F., Tang,P. and Yu,Z.<br>USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1<br>Cell Death Dis (2023) 14, 730-730. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2022
  24. Bailly,C.<br>Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora<br>Bioorg Med Chem (2022) 70, 116935-116935. PubMed  Europe PubMed DOI  V  I
  25. Das,T., Lee,E.Y., You,H.J., Kim,E.E. and Song,E.J.<br>USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1<br>Cell Death Discov (2022) 8, 24-24. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Pu,J.Y., Zhang,Y., Wang,L.X., Wang,J. and Zhou,J.H.<br>Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type I<br>Curr Med Sci (2022) 42, 1000-1006. PubMed  Europe PubMed DOI  K
  27. Tao,Y. and You,W.<br>The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in Gastric Cancer and Mediates NF-kappaB Signaling by Regulating PRL-3 Expression<br>Front Biosci (Landmark Ed) (2022) 27, 286-286. PubMed  Europe PubMed DOI  K
    28. 2021
  28. Hou,X., Zhu,F., Ni,Y., Chen,T., Du,J., Liu,X., Han,Y., Liu,Y., Du,W., Li,Y., Wang,X., Li,D., Liang,R., Li,B. and Shi,G.<br>USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response<br>Life Sci (2021) 281, 119720-119720. PubMed  Europe PubMed DOI
  29. Hu,B., Zhang,D., Zhao,K., Wang,Y., Pei,L., Fu,Q. and Ma,X.<br>Spotlight on USP4: Structure, Function, and Regulation<br>Front Cell Dev Biol (2021) 9, 595159-595159. PubMed  Europe PubMed DOI  PMC  EPMC  V
  30. Xu,J., Chen,D., Jin,L., Chen,Z., Tu,Y., Huang,X., Xue,F., Xu,J., Chen,M., Wang,X. and Chen,Y.<br>Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling<br>J Cell Mol Med (2021) 25, 1140-1150. PubMed  Europe PubMed DOI  K  I
  31. Yang,Y., Fan,X., Ren,Y., Wu,K., Tian,X., Wen,F., Liu,D., Fan,Y. and Zhao,S.<br>SOX2-Upregulated microRNA-30e Promotes the Progression of Esophageal Cancer via Regulation of the USP4/SMAD4/CK2 Axis<br>Mol Ther Nucleic Acids (2021) 23, 200-214. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2020
  32. Lai,C.Y., Yeh,D.W., Lu,C.H., Liu,Y.L., Chuang,Y.C., Ruan,J.W., Kao,C.Y., Huang,L.R. and Chuang,T.H.<br>Epigenetic silencing of ubiquitin specific protease 4 by Snail1 contributes to macrophage-dependent inflammation and therapeutic resistance in lung cancer<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  33. Li,F., Hu,Q., He,T., Xu,J., Yi,Y., Xie,S., Ding,L., Fu,M., Guo,R., Xiao,Z.J. and Niu,M.<br>The Deubiquitinase USP4 Stabilizes Twist1 Protein to Promote Lung Cancer Cell Stemness<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  34. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.<br>Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  35. Wang,Y., Zhou,L., Lu,J., Jiang,B., Liu,C. and Guo,J.<br>USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target<br>Cancer Cell Int (2020) 20, 298-298. PubMed  Europe PubMed DOI  PMC  EPMC  V
  36. Wang,Y., Zhou,L., Lu,J., Jiang,B., Liu,C., Liang,Z., Zhou,W. and Guo,J.<br>Ubiquitin-specific protease 4 predicts an unfavorable prognosis and promotes malignant behaviors in vitro in pancreatic cancer<br>Exp Cell Res (2020) 396, 112317-112317. PubMed  Europe PubMed DOI  K
    37. 2019
  37. Murali,S.K., Aroankins,T.S., Moeller,H.B. and Fenton,R.A.<br>The deubiquitylase USP4 interacts with the water channel AQP2 to modulate its apical membrane accumulation and cellular abundance<br>Cells (2019) 8 PubMed  Europe PubMed DOI
  38. Nguyen,H.H., Kim,T., Nguyen,T., Hahn,M.J., Yun,S.I. and Kim,K.K.<br>A selective inhibitor of ubiquitin-specific protease 4 suppresses colorectal cancer progression by regulating beta-catenin signaling<br>Cell Physiol Biochem (2019) 53, 157-171. PubMed  Europe PubMed DOI  I
  39. Qin,N., Han,F., Li,L., Ge,Y., Lin,W., Wang,J., Wu,L., Zhao,G., Deng,Y. and Zhang,J.<br>Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity<br>Oncol Lett (2019) 17, 958-964. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Zhou,J., Qiu,T., Wang,T., Chen,Z., Ma,X., Zhang,L. and Zou,J.<br>USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling<br>Clin Sci (Lond) (2019) 133, 335-349. PubMed  Europe PubMed DOI  K
    41. 2018
  41. Zhao,Y., Wang,F., Gao,L., Xu,L., Tong,R., Lin,N., Su,Y., Yan,Y., Gao,Y., He,J., Kong,L., Yuan,A., Zhuge,Y. and Pu,J.<br>Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease in mice<br>Hepatology (2018) 68, 897-917. PubMed  Europe PubMed DOI
    42. 2017
  42. Guo,Z., Xu,P., Ge,S., Zhang,C., Zheng,X., Xu,J., Liu,Z., Li,B. and Ge,S.<br>Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells<br>Int J Mol Med (2017) 40, 979-986. PubMed  Europe PubMed DOI
  43. Kotani,Y., Morito,D., Sakata,K., Ainuki,S., Sugihara,M., Hatta,T., Iemura,S.I., Takashima,S., Natsume,T. and Nagata,K.<br>Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor<br>Sci Rep (2017) 7, 44293-44293. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Kwon,S.K., Kim,E.H. and Baek,K.H.<br>RNPS1 is modulated by ubiquitin-specific protease 4<br>FEBS Lett (2017) 591, 369-381. PubMed  Europe PubMed DOI
  45. Lin,R., Nie,J., Ren,J., Liang,R., Li,D., Wang,P., Gao,C., Zhuo,C., Yang,C. and Li,B.<br>USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells<br>FEBS Lett (2017) 591, 1677-1686. PubMed  Europe PubMed DOI
  46. Liu,C., Liu,C., Liu,H., Gong,L., Tao,T., Shen,Y., Zhu,S. and Shen,A.<br>Increased expression of ubiquitin-specific protease 4 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats<br>Cell Mol Neurobiol (2017) 37, 427-435. PubMed  Europe PubMed DOI
  47. Yun,S.I. and Kim,K.K.<br>Ubiquitin-specific protease 4 (USP4) suppresses myoblast differentiation by down regulating MyoD activity in a catalytic-independent manner<br>Cell Signal (2017) 35, 48-60. PubMed  Europe PubMed DOI
    48. 2016
  48. He,B., Zhao,Y.C., Gao,L.C., Ying,X.Y., Xu,L.W., Su,Y.Y., Ji,Q.Q., Lin,N. and Pu,J.<br>Ubiquitin-specific protease 4 is an endogenous negative regulator of pathological cardiac hypertrophy<br>Hypertension (2016) 67, 1237-1248. PubMed  Europe PubMed DOI  K
  49. Hwang,S.J., Lee,H.W., Kim,H.R., Lee,H., Shin,C.H., Yun,S.I., Lee,D.H., Kim,D.H., Kim,K.K., Joo,K.M. and Kim,H.H.<br>Ubiquitin-specific protease 4 controls metastatic potential through beta-catenin stabilization in brain metastatic lung adenocarcinoma<br>Sci Rep (2016) 6, 21596-21596. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Li,Y., Jiang,D., Zhang,Q., Liu,X. and Cai,Z.<br>Ubiquitin-specific protease 4 inhibits breast cancer cell growth through the upregulation of PDCD4<br>Int J Mol Med (2016) 38, 803-811. PubMed  Europe PubMed DOI
  51. Li,Z., Hao,Q., Luo,J., Xiong,J., Zhang,S., Wang,T., Bai,L., Wang,W., Chen,M., Wang,W., Gu,L., Lv,K. and Chen,J.<br>USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2<br>Oncogene (2016) 35, 2902-2912. PubMed  Europe PubMed DOI
  52. Park,J.K., Das,T., Song,E.J. and Kim,E.E.<br>Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3<br>Nucleic Acids Res (2016) 44, 5424-5437. PubMed  Europe PubMed DOI
  53. Vlasschaert,C., Xia,X. and Gray,D.A.<br>Selection preserves ubiquitin specific protease 4 alternative exon skipping in therian mammals<br>Sci Rep (2016) 6, 20039-20039. PubMed  Europe PubMed DOI  PMC  EPMC  R
  54. Zhou,F., Li,F., Fang,P., Dai,T., Yang,B., van Dam,H., Jia,J., Zheng,M. and Zhang,L.<br>Ubiquitin-specific protease 4 antagonizes osteoblast differentiation through Dishevelled<br>J Bone Miner Res (2016) 31, 1888-1898. PubMed  Europe PubMed DOI
    55. 2015
  55. Liu,H., Zhang,H., Wang,X., Tian,Q., Hu,Z., Peng,C., Jiang,P., Wang,T., Guo,W., Chen,Y., Li,X., Zhang,P. and Pei,H.<br>The deubiquitylating enzyme USP4 cooperates with CtIP in DNA double-strand break end resection<br>Cell Rep (2015) 13, 93-107. PubMed  Europe PubMed DOI
  56. Vlasschaert,C., Xia,X., Coulombe,J. and Gray,D.A.<br>Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11<br>BMC Evol Biol (2015) 15, 230-230. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Wijnhoven,P., Konietzny,R., Blackford,A.N., Travers,J., Kessler,B.M., Nishi,R. and Jackson,S.P.<br>USP4 Auto-Deubiquitylation Promotes Homologous Recombination<br>Mol Cell (2015) 60, 362-373. PubMed  Europe PubMed DOI
  58. Yang,J., Xu,P., Han,L., Guo,Z., Wang,X., Chen,Z., Nie,J., Yin,S., Piccioni,M., Tsun,A., Lv,L., Ge,S. and Li,B.<br>Cutting edge: ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORgammat<br>J Immunol (2015) 194, 4094-4097. PubMed  Europe PubMed DOI  T  I
  59. Yun,S.I., Kim,H.H., Yoon,J.H., Park,W.S., Hahn,M.J., Kim,H.C., Chung,C.H. and Kim,K.K.<br>Ubiquitin specific protease 4 positively regulates the WNT/beta-catenin signaling in colorectal cancer<br>Mol Oncol (2015) 9, 1834-1851. PubMed  Europe PubMed DOI
    60. 2014
  60. Clerici,M., Luna-Vargas,M.P., Faesen,A.C. and Sixma,T.K.<br>The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange<br>Nat Commun (2014) 5, 5399-5399. PubMed  Europe PubMed DOI
    61. 2013
  61. Hou,X., Wang,L., Zhang,L., Pan,X. and Zhao,W.<br>Ubiquitin-specific protease 4 promotes TNF-alpha-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma<br>FEBS Lett (2013) 587, 311-316. PubMed  Europe PubMed DOI
  62. Wang,L., Zhao,W., Zhang,M., Wang,P., Zhao,K., Zhao,X., Yang,S. and Gao,C.<br>USP4 positively regulates RIG-I-mediated antiviral response through deubiquitination and stabilization of RIG-I<br>J Virol (2013) 87, 4507-4515. PubMed  Europe PubMed DOI
    63. 2012
  63. Faesen,A.C., Luna-Vargas,M.P. and Sixma,T.K.<br>The role of UBL domains in ubiquitin-specific proteases<br>Biochem Soc Trans (2012) 40, 539-545. PubMed  Europe PubMed DOI
  64. Gray,D.A.<br>Ubiquitin-specific proteases 4 and 15<br>[ISSN:978-0-12-407743-0] (2012) 3, 2052-2057. DOI
  65. Xiao,N., Li,H., Luo,J., Wang,R., Chen,H., Chen,J. and Wang,P.<br>Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFalpha-induced cancer cell migration<br>Biochem J (2012) 441, 979-986. PubMed  Europe PubMed DOI
  66. Zhang,L., Zhou,F., Drabsch,Y., Gao,R., Snaar-Jagalska,B.E., Mickanin,C., Huang,H., Sheppard,K.A., Porter,J.A., Lu,C.X. and ten Dijke,P.<br>USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-beta type I receptor<br>Nat Cell Biol (2012) 14, 717-726. PubMed  Europe PubMed DOI
  67. Zhao,B., Velasco,K., Sompallae,R., Pfirrmann,T., Masucci,M.G. and Lindsten,K.<br>The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome<br>Biochem Biophys Res Commun (2012) 427, 490-496. PubMed  Europe PubMed DOI
  68. Zhou,F., Zhang,X., van Dam,H., ten Dijke,P., Huang,H. and Zhang,L.<br>Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation<br>J Biol Chem (2012) 287, 11002-11010. PubMed  Europe PubMed DOI
    69. 2011
  69. Elliott,P.R., Liu,H., Pastok,M.W., Grossmann,G.J., Rigden,D.J., Clague,M.J., Urbe,S. and Barsukov,I.L.<br>Structural variability of the ubiquitin specific protease DUSP-UBL double domains<br>FEBS Lett (2011) 585, 3385-3390. PubMed  Europe PubMed DOI  S
  70. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.<br>The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types<br>Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
  71. Fan,Y.H., Yu,Y., Mao,R.F., Tan,X.J., Xu,G.F., Zhang,H., Lu,X.B., Fu,S.B. and Yang,J.<br>USP4 targets TAK1 to downregulate TNFalpha-induced NF-kappaB activation<br>Cell Death Differ (2011) 18, 1547-1560. PubMed  Europe PubMed DOI
  72. Zhang,X., Berger,F.G., Yang,J. and Lu,X.<br>USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1<br>EMBO J (2011) 30, 2177-2189. PubMed  Europe PubMed DOI
    73. 2010
  73. Song,E.J., Werner,S.L., Neubauer,J., Stegmeier,F., Aspden,J., Rio,D., Harper,J.W., Elledge,S.J., Kirschner,M.W. and Rape,M.<br>The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome<br>Genes Dev (2010) 24, 1434-1447. PubMed  Europe PubMed DOI
    74. 2009
  74. Zhao,B., Schlesiger,C., Masucci,M.G. and Lindsten,K.<br>The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway<br>J Cell Mol Med (2009) 13, 1886-1895. PubMed  Europe PubMed DOI
    75. 2008
  75. Liu,L., Spurrier,J., Butt,T.R. and Strickler,J.E.<br>Enhanced protein expression in the baculovirus/insect cell system using engineered SUMO fusions<br>Protein Expr Purif (2008) 62, 21-28. PubMed  Europe PubMed DOI  PMC  EPMC  E
    76. 2006
  76. Wada,K., Tanji,K. and Kamitani,T.<br>Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity<br>Biochem Biophys Res Commun (2006) 339, 731-736. PubMed  Europe PubMed DOI
  77. Wada,K. and Kamitani,T.<br>UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself<br>Biochem Biophys Res Commun (2006) 342, 253-258. PubMed  Europe PubMed DOI
    78. 2005
  78. Soboleva,T.A., Jans,D.A., Johnson-Saliba,M. and Baker,R.T.<br>Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme<br>J Biol Chem (2005) 280, 745-752. PubMed  Europe PubMed DOI
    79. 2004
  79. Baker,R.T.<br>Ubiquitin-specific proteases 4 and 15<br>[ISSN:0-12-079610-4] (2004) 2, 1232-1236.  V
    80. 2001
  80. [YEAR:6-9-2001]Blanchette,P., Gilchrist,C.A., Baker,R.T. and Gray,D.A.<br>Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130<br>Oncogene (6-9-2001) 20, 5533-5537. PubMed  Europe PubMed DOI
  81. [YEAR:6-9-2001]DeSalle,L.M., Latres,E., Lin,D., Graner,E., Montagnoli,A., Baker,R.T., Pagano,M. and Loda,M.<br>The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein<br>Oncogene (6-9-2001) 20, 5538-5542. PubMed  Europe PubMed DOI
    82. 2000
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