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Literature for peptidase C19.010: ubiquitin-specific peptidase 4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, T Target, R Splicing, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Jiang,X., Wang,Y., Zhang,X., Deng,H., Fang,L., Tafadzwa,C., Yao,J., Chen,H., Ye,A., Zhou,K., Ling,X. and Xiao,J.
    Melatonin-engineered MSCs-exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival
    Clin Transl Med (2026) 16, e70565-e70565. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Chen,S., Yang,J., Qi,G., Zhao,J., Chen,Y., Guo,X., Zhang,J., Gan,J., Jian,Z. and Jin,J.
    Evodiamine inhibits colorectal cancer cell stemness by disturbing ubiquitin specific protease 4 mediated SOX9 stabilization
    Discov Oncol (2025) 16, 403-403. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Li,F., Zhou,Y., Lin,X., Zhang,Y., Hu,Q., Zhao,E., Li,H., Pan,X., Shu,F., Zhang,K., Huang,C., Tang,N. and Liao,W.
    A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting beta-catenin and Twist1 degradation
    J Transl Med (2025) 23, 114-114. PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Liu,Z., Li,X., He,Y., Xie,F., Zhang,Y., Huang,M., Wang,Y. and Zhu,W.
    A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade
    J Orthop Surg Res (2025) 20, 220-220. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Park,T., Forbush,K., Li,Y., Vivas,O., Rosenthal,K.J., Falcone,J., Wong,C.J., Bruce,J.E., Moreno,C., Dessauer,C.W. and Scott,J.D.
    Long AKAP18 isoforms anchor ubiquitin specific proteinases and coordinate calcium reuptake at the sarcoplasmic reticulum
    J Biol Chem (2025) , 110317-110317. PubMed  Europe PubMed DOI
  6. Tu,Y., Xu,L., Fu,G., Wang,J., Xia,P., Tao,Z., Ye,Y., Hu,J., Cai,W., Zhu,H., Wu,Q. and Ji,J.
    Lactylation-driven USP4-mediated ANXA2 stabilization and activation promotes maintenance and radioresistance of glioblastoma stem cells
    Cell Death Differ (2025) PubMed  Europe PubMed DOI
  7. Xie,Z., Lin,H., Wu,Y., Yu,Y., Liu,X., Zheng,Y., Wang,X., Wu,J., Xu,M., Han,Y., Zhang,Q., Deng,Y., Lin,L., Linzhu,Y., Qingyun,L., Lin,X., Huang,Y. and Chi,P.
    USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer
    Cell Death Dis (2025) 16, 81-81. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Zhang,J., Allen,J., Ward,S.J., Dekker,L.V. and Dreveny,I.
    A versatile fluorescence polarization based deubiquitination assay using an isopeptide bond substrate mimetic (IsoMim)
    J Biol Chem (2025) , 110342-110342. PubMed  Europe PubMed DOI  I
  9. Zhao,X., Lu,S., Xiang,Z., Yan,M., Zhu,Z.G., Dong,F. and Yan,C.
    USP4-Mediated deubiquitination of A2AR suppresses autophagy-dependent ferroptosis in gastric cancer
    Cell Mol Life Sci (2025) 82, 342-342. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zhou,S., Li,Y., Wang,C., Zhao,Y. and Zheng,X.
    K11- and K29-ubiquitination-mediated nuclear translocation of glycolytic enzyme aldolase A promotes pancreatic cancer progression by NF-kappaB activation
    Cell Death Differ (2025) PubMed  Europe PubMed DOI
    11. 2024
  11. Chu,F., Hou,P., Zhu,H., Gao,Y., Wang,X., He,W., Ren,J., Li,M., Liu,Y., Chang He,D., Wang,H., Gao,Y. and He,H.
    PBLD enhances antiviral innate immunity by promoting the p53-USP4-MAVS signaling axis
    Proc Natl Acad Sci U S A (2024) 121, e2401174121-e2401174121. PubMed  Europe PubMed DOI
  12. Guo,X., Ma,Y., Zhang,T., Liu,R., Chang,F., Yan,X., Yu,T., Wu,P., Li,Q., Xu,L., Duan,J., Li,L., Su,Y. and Shao,G.
    The deubiquitinating enzyme USP4 regulates BRCA1 stability and function
    NPJ Breast Cancer (2024) 10, 35-35. PubMed  Europe PubMed DOI  PMC  EPMC  K
  13. Hu,C., Zhang,W., Jia,Y., Zhao,J., Chen,Q., Hao,C. and Yu,Y.
    USP4 promotes PTC progression by stabilizing LDHA and activating the MAPK and AKT signaling pathway
    Aging (Albany NY) (2024) null PubMed  Europe PubMed DOI
  14. Kang,S., Liu,S., Dong,X., Li,H., Qian,Y., Dai,A., He,W., Li,X., Chen,Q., Wang,H. and Ding,P.H.
    USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis
    Autophagy (2024) , 1-18. PubMed  Europe PubMed DOI  K
  15. Kim,J., Taketomi,T., Yamada,A., Uematsu,Y., Ueda,K., Chiba,T. and Tsuruta,F.
    USP4 regulates TUT1 ubiquitination status in concert with SART3
    Biochem Biophys Res Commun (2024) 701, 149557-149557. PubMed  Europe PubMed DOI
  16. Li,X., Yan,C., Yun,J., Xu,X., Wei,H., Xu,X., Li,Y. and Yi,J.
    USP4/CARM1 Axis Promotes the Malignant Transformation of Breast Cancer Cells by Upregulating SLC7A11 Expression
    Clin Breast Cancer (2024) PubMed  Europe PubMed DOI
  17. Liu,B., Zhang,X., Zhou,Y., Liu,H., Wang,Z., Fu,Y., Gao,Q., Cheng,X., Sun,Q. and Ju,Z.
    USP4 regulates ribosome biogenesis and protein synthesis for hematopoietic stem cell regeneration and leukemia progression
    Leukemia (2024) 38, 2466-2478. PubMed  Europe PubMed DOI
  18. Mao,M., Xia,Q., Zhan,G., Bing,H., Zhang,C., Wang,J., Tian,W., Lian,H., Li,X. and Chu,Q.
    Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination
    Phytomedicine (2024) 124, 155304-155304. PubMed  Europe PubMed DOI  I
  19. Wu,X., Hong,J. and Hong,L.
    The Deubiquitinating Enzyme USP4 Promotes Trophoblast Dysfunction by Stabilizing RYBP
    Cell Biochem Biophys (2024) PubMed  Europe PubMed DOI
  20. Zhou,Y., Li,H., Zhang,Y., Zhao,E., Huang,C., Pan,X., Shu,F., Liu,Z., Tang,N., Li,F. and Liao,W.
    Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer
    Cancer Lett (2024) 589, 216836-216836. PubMed  Europe PubMed DOI
    21. 2023
  21. Chen,Y., Guo,Y., Yuan,M., Guo,S., Cui,S. and Chen,D.
    USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2
    PLoS ONE (2023) 18, e0290688-e0290688. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Zhang,D.G., Kunz,W.S., Lei,X.J., Zito,E., Zhao,T., Xu,Y.C., Wei,X.L., Lv,W.H. and Luo,Z.
    Selenium Ameliorated Oxidized Fish Oil-Induced Lipotoxicity via the Inhibition of Mitochondrial Oxidative Stress, Remodeling of Usp4-Mediated Deubiquitination, and Stabilization of Pparalpha
    Antioxid Redox Signal (2023) PubMed  Europe PubMed DOI  K
  23. Zhang,H., Han,Y., Xiao,W., Gao,Y., Sui,Z., Ren,P., Meng,F., Tang,P. and Yu,Z.
    USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1
    Cell Death Dis (2023) 14, 730-730. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2022
  24. Bailly,C.
    Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora
    Bioorg Med Chem (2022) 70, 116935-116935. PubMed  Europe PubMed DOI  V  I
  25. Das,T., Lee,E.Y., You,H.J., Kim,E.E. and Song,E.J.
    USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1
    Cell Death Discov (2022) 8, 24-24. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Pu,J.Y., Zhang,Y., Wang,L.X., Wang,J. and Zhou,J.H.
    Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type I
    Curr Med Sci (2022) 42, 1000-1006. PubMed  Europe PubMed DOI  K
  27. Tao,Y. and You,W.
    The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in Gastric Cancer and Mediates NF-kappaB Signaling by Regulating PRL-3 Expression
    Front Biosci (Landmark Ed) (2022) 27, 286-286. PubMed  Europe PubMed DOI  K
    28. 2021
  28. Hou,X., Zhu,F., Ni,Y., Chen,T., Du,J., Liu,X., Han,Y., Liu,Y., Du,W., Li,Y., Wang,X., Li,D., Liang,R., Li,B. and Shi,G.
    USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response
    Life Sci (2021) 281, 119720-119720. PubMed  Europe PubMed DOI
  29. Hu,B., Zhang,D., Zhao,K., Wang,Y., Pei,L., Fu,Q. and Ma,X.
    Spotlight on USP4: Structure, Function, and Regulation
    Front Cell Dev Biol (2021) 9, 595159-595159. PubMed  Europe PubMed DOI  PMC  EPMC  V
  30. Xu,J., Chen,D., Jin,L., Chen,Z., Tu,Y., Huang,X., Xue,F., Xu,J., Chen,M., Wang,X. and Chen,Y.
    Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling
    J Cell Mol Med (2021) 25, 1140-1150. PubMed  Europe PubMed DOI  K  I
  31. Yang,Y., Fan,X., Ren,Y., Wu,K., Tian,X., Wen,F., Liu,D., Fan,Y. and Zhao,S.
    SOX2-Upregulated microRNA-30e Promotes the Progression of Esophageal Cancer via Regulation of the USP4/SMAD4/CK2 Axis
    Mol Ther Nucleic Acids (2021) 23, 200-214. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2020
  32. Lai,C.Y., Yeh,D.W., Lu,C.H., Liu,Y.L., Chuang,Y.C., Ruan,J.W., Kao,C.Y., Huang,L.R. and Chuang,T.H.
    Epigenetic silencing of ubiquitin specific protease 4 by Snail1 contributes to macrophage-dependent inflammation and therapeutic resistance in lung cancer
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  33. Li,F., Hu,Q., He,T., Xu,J., Yi,Y., Xie,S., Ding,L., Fu,M., Guo,R., Xiao,Z.J. and Niu,M.
    The Deubiquitinase USP4 Stabilizes Twist1 Protein to Promote Lung Cancer Cell Stemness
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  34. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  35. Wang,Y., Zhou,L., Lu,J., Jiang,B., Liu,C. and Guo,J.
    USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target
    Cancer Cell Int (2020) 20, 298-298. PubMed  Europe PubMed DOI  PMC  EPMC  V
  36. Wang,Y., Zhou,L., Lu,J., Jiang,B., Liu,C., Liang,Z., Zhou,W. and Guo,J.
    Ubiquitin-specific protease 4 predicts an unfavorable prognosis and promotes malignant behaviors in vitro in pancreatic cancer
    Exp Cell Res (2020) 396, 112317-112317. PubMed  Europe PubMed DOI  K
    37. 2019
  37. Murali,S.K., Aroankins,T.S., Moeller,H.B. and Fenton,R.A.
    The deubiquitylase USP4 interacts with the water channel AQP2 to modulate its apical membrane accumulation and cellular abundance
    Cells (2019) 8 PubMed  Europe PubMed DOI
  38. Nguyen,H.H., Kim,T., Nguyen,T., Hahn,M.J., Yun,S.I. and Kim,K.K.
    A selective inhibitor of ubiquitin-specific protease 4 suppresses colorectal cancer progression by regulating beta-catenin signaling
    Cell Physiol Biochem (2019) 53, 157-171. PubMed  Europe PubMed DOI  I
  39. Qin,N., Han,F., Li,L., Ge,Y., Lin,W., Wang,J., Wu,L., Zhao,G., Deng,Y. and Zhang,J.
    Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity
    Oncol Lett (2019) 17, 958-964. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Zhou,J., Qiu,T., Wang,T., Chen,Z., Ma,X., Zhang,L. and Zou,J.
    USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling
    Clin Sci (Lond) (2019) 133, 335-349. PubMed  Europe PubMed DOI  K
    41. 2018
  41. Zhao,Y., Wang,F., Gao,L., Xu,L., Tong,R., Lin,N., Su,Y., Yan,Y., Gao,Y., He,J., Kong,L., Yuan,A., Zhuge,Y. and Pu,J.
    Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease in mice
    Hepatology (2018) 68, 897-917. PubMed  Europe PubMed DOI
    42. 2017
  42. Guo,Z., Xu,P., Ge,S., Zhang,C., Zheng,X., Xu,J., Liu,Z., Li,B. and Ge,S.
    Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells
    Int J Mol Med (2017) 40, 979-986. PubMed  Europe PubMed DOI
  43. Kotani,Y., Morito,D., Sakata,K., Ainuki,S., Sugihara,M., Hatta,T., Iemura,S.I., Takashima,S., Natsume,T. and Nagata,K.
    Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor
    Sci Rep (2017) 7, 44293-44293. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Kwon,S.K., Kim,E.H. and Baek,K.H.
    RNPS1 is modulated by ubiquitin-specific protease 4
    FEBS Lett (2017) 591, 369-381. PubMed  Europe PubMed DOI
  45. Lin,R., Nie,J., Ren,J., Liang,R., Li,D., Wang,P., Gao,C., Zhuo,C., Yang,C. and Li,B.
    USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells
    FEBS Lett (2017) 591, 1677-1686. PubMed  Europe PubMed DOI
  46. Liu,C., Liu,C., Liu,H., Gong,L., Tao,T., Shen,Y., Zhu,S. and Shen,A.
    Increased expression of ubiquitin-specific protease 4 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats
    Cell Mol Neurobiol (2017) 37, 427-435. PubMed  Europe PubMed DOI
  47. Yun,S.I. and Kim,K.K.
    Ubiquitin-specific protease 4 (USP4) suppresses myoblast differentiation by down regulating MyoD activity in a catalytic-independent manner
    Cell Signal (2017) 35, 48-60. PubMed  Europe PubMed DOI
    48. 2016
  48. He,B., Zhao,Y.C., Gao,L.C., Ying,X.Y., Xu,L.W., Su,Y.Y., Ji,Q.Q., Lin,N. and Pu,J.
    Ubiquitin-specific protease 4 is an endogenous negative regulator of pathological cardiac hypertrophy
    Hypertension (2016) 67, 1237-1248. PubMed  Europe PubMed DOI  K
  49. Hwang,S.J., Lee,H.W., Kim,H.R., Lee,H., Shin,C.H., Yun,S.I., Lee,D.H., Kim,D.H., Kim,K.K., Joo,K.M. and Kim,H.H.
    Ubiquitin-specific protease 4 controls metastatic potential through beta-catenin stabilization in brain metastatic lung adenocarcinoma
    Sci Rep (2016) 6, 21596-21596. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Li,Y., Jiang,D., Zhang,Q., Liu,X. and Cai,Z.
    Ubiquitin-specific protease 4 inhibits breast cancer cell growth through the upregulation of PDCD4
    Int J Mol Med (2016) 38, 803-811. PubMed  Europe PubMed DOI
  51. Li,Z., Hao,Q., Luo,J., Xiong,J., Zhang,S., Wang,T., Bai,L., Wang,W., Chen,M., Wang,W., Gu,L., Lv,K. and Chen,J.
    USP4 inhibits p53 and NF-kappaB through deubiquitinating and stabilizing HDAC2
    Oncogene (2016) 35, 2902-2912. PubMed  Europe PubMed DOI
  52. Park,J.K., Das,T., Song,E.J. and Kim,E.E.
    Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3
    Nucleic Acids Res (2016) 44, 5424-5437. PubMed  Europe PubMed DOI
  53. Vlasschaert,C., Xia,X. and Gray,D.A.
    Selection preserves ubiquitin specific protease 4 alternative exon skipping in therian mammals
    Sci Rep (2016) 6, 20039-20039. PubMed  Europe PubMed DOI  PMC  EPMC  R
  54. Zhou,F., Li,F., Fang,P., Dai,T., Yang,B., van Dam,H., Jia,J., Zheng,M. and Zhang,L.
    Ubiquitin-specific protease 4 antagonizes osteoblast differentiation through Dishevelled
    J Bone Miner Res (2016) 31, 1888-1898. PubMed  Europe PubMed DOI
    55. 2015
  55. Liu,H., Zhang,H., Wang,X., Tian,Q., Hu,Z., Peng,C., Jiang,P., Wang,T., Guo,W., Chen,Y., Li,X., Zhang,P. and Pei,H.
    The deubiquitylating enzyme USP4 cooperates with CtIP in DNA double-strand break end resection
    Cell Rep (2015) 13, 93-107. PubMed  Europe PubMed DOI
  56. Vlasschaert,C., Xia,X., Coulombe,J. and Gray,D.A.
    Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11
    BMC Evol Biol (2015) 15, 230-230. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Wijnhoven,P., Konietzny,R., Blackford,A.N., Travers,J., Kessler,B.M., Nishi,R. and Jackson,S.P.
    USP4 Auto-Deubiquitylation Promotes Homologous Recombination
    Mol Cell (2015) 60, 362-373. PubMed  Europe PubMed DOI
  58. Yang,J., Xu,P., Han,L., Guo,Z., Wang,X., Chen,Z., Nie,J., Yin,S., Piccioni,M., Tsun,A., Lv,L., Ge,S. and Li,B.
    Cutting edge: ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORgammat
    J Immunol (2015) 194, 4094-4097. PubMed  Europe PubMed DOI  T  I
  59. Yun,S.I., Kim,H.H., Yoon,J.H., Park,W.S., Hahn,M.J., Kim,H.C., Chung,C.H. and Kim,K.K.
    Ubiquitin specific protease 4 positively regulates the WNT/beta-catenin signaling in colorectal cancer
    Mol Oncol (2015) 9, 1834-1851. PubMed  Europe PubMed DOI
    60. 2014
  60. Clerici,M., Luna-Vargas,M.P., Faesen,A.C. and Sixma,T.K.
    The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange
    Nat Commun (2014) 5, 5399-5399. PubMed  Europe PubMed DOI
    61. 2013
  61. Hou,X., Wang,L., Zhang,L., Pan,X. and Zhao,W.
    Ubiquitin-specific protease 4 promotes TNF-alpha-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma
    FEBS Lett (2013) 587, 311-316. PubMed  Europe PubMed DOI
  62. Wang,L., Zhao,W., Zhang,M., Wang,P., Zhao,K., Zhao,X., Yang,S. and Gao,C.
    USP4 positively regulates RIG-I-mediated antiviral response through deubiquitination and stabilization of RIG-I
    J Virol (2013) 87, 4507-4515. PubMed  Europe PubMed DOI
    63. 2012
  63. Faesen,A.C., Luna-Vargas,M.P. and Sixma,T.K.
    The role of UBL domains in ubiquitin-specific proteases
    Biochem Soc Trans (2012) 40, 539-545. PubMed  Europe PubMed DOI
  64. Gray,D.A.
    Ubiquitin-specific proteases 4 and 15
    [ISSN:978-0-12-407743-0] (2012) 3, 2052-2057. DOI
  65. Xiao,N., Li,H., Luo,J., Wang,R., Chen,H., Chen,J. and Wang,P.
    Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFalpha-induced cancer cell migration
    Biochem J (2012) 441, 979-986. PubMed  Europe PubMed DOI
  66. Zhang,L., Zhou,F., Drabsch,Y., Gao,R., Snaar-Jagalska,B.E., Mickanin,C., Huang,H., Sheppard,K.A., Porter,J.A., Lu,C.X. and ten Dijke,P.
    USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-beta type I receptor
    Nat Cell Biol (2012) 14, 717-726. PubMed  Europe PubMed DOI
  67. Zhao,B., Velasco,K., Sompallae,R., Pfirrmann,T., Masucci,M.G. and Lindsten,K.
    The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome
    Biochem Biophys Res Commun (2012) 427, 490-496. PubMed  Europe PubMed DOI
  68. Zhou,F., Zhang,X., van Dam,H., ten Dijke,P., Huang,H. and Zhang,L.
    Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation
    J Biol Chem (2012) 287, 11002-11010. PubMed  Europe PubMed DOI
    69. 2011
  69. Elliott,P.R., Liu,H., Pastok,M.W., Grossmann,G.J., Rigden,D.J., Clague,M.J., Urbe,S. and Barsukov,I.L.
    Structural variability of the ubiquitin specific protease DUSP-UBL double domains
    FEBS Lett (2011) 585, 3385-3390. PubMed  Europe PubMed DOI  S
  70. Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
    The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
    Chem Biol (2011) 18, 1550-1561. PubMed  Europe PubMed DOI
  71. Fan,Y.H., Yu,Y., Mao,R.F., Tan,X.J., Xu,G.F., Zhang,H., Lu,X.B., Fu,S.B. and Yang,J.
    USP4 targets TAK1 to downregulate TNFalpha-induced NF-kappaB activation
    Cell Death Differ (2011) 18, 1547-1560. PubMed  Europe PubMed DOI
  72. Zhang,X., Berger,F.G., Yang,J. and Lu,X.
    USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1
    EMBO J (2011) 30, 2177-2189. PubMed  Europe PubMed DOI
    73. 2010
  73. Song,E.J., Werner,S.L., Neubauer,J., Stegmeier,F., Aspden,J., Rio,D., Harper,J.W., Elledge,S.J., Kirschner,M.W. and Rape,M.
    The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome
    Genes Dev (2010) 24, 1434-1447. PubMed  Europe PubMed DOI
    74. 2009
  74. Zhao,B., Schlesiger,C., Masucci,M.G. and Lindsten,K.
    The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway
    J Cell Mol Med (2009) 13, 1886-1895. PubMed  Europe PubMed DOI
    75. 2008
  75. Liu,L., Spurrier,J., Butt,T.R. and Strickler,J.E.
    Enhanced protein expression in the baculovirus/insect cell system using engineered SUMO fusions
    Protein Expr Purif (2008) 62, 21-28. PubMed  Europe PubMed DOI  PMC  EPMC  E
    76. 2006
  76. Wada,K., Tanji,K. and Kamitani,T.
    Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity
    Biochem Biophys Res Commun (2006) 339, 731-736. PubMed  Europe PubMed DOI
  77. Wada,K. and Kamitani,T.
    UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself
    Biochem Biophys Res Commun (2006) 342, 253-258. PubMed  Europe PubMed DOI
    78. 2005
  78. Soboleva,T.A., Jans,D.A., Johnson-Saliba,M. and Baker,R.T.
    Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme
    J Biol Chem (2005) 280, 745-752. PubMed  Europe PubMed DOI
    79. 2004
  79. Baker,R.T.
    Ubiquitin-specific proteases 4 and 15
    [ISSN:0-12-079610-4] (2004) 2, 1232-1236.  V
    80. 2001
  80. [YEAR:6-9-2001]Blanchette,P., Gilchrist,C.A., Baker,R.T. and Gray,D.A.
    Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130
    Oncogene (6-9-2001) 20, 5533-5537. PubMed  Europe PubMed DOI
  81. [YEAR:6-9-2001]DeSalle,L.M., Latres,E., Lin,D., Graner,E., Montagnoli,A., Baker,R.T., Pagano,M. and Loda,M.
    The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein
    Oncogene (6-9-2001) 20, 5538-5542. PubMed  Europe PubMed DOI
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