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Literature for peptidase C16.012: coronavirus COVID-19 papain-like peptidase

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: T Target, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bader,M., Calleja,D.J., Devine,S.M., Kuchel,N.W., Lu,B.G.C., Wu,X., Birkinshaw,R.W., Bhandari,R., Loi,K., Volpe,R., Khakham,Y., Au,A.E., Blackmore,T.R., Mackiewicz,L., Dayton,M., Schaefer,J., Scherer,L., Stock,A.T., Cooney,J.P., Schoffer,K., Maluenda,A., Kleeman,E.A., Davidson,K.C., Allison,C.C., Ebert,G., Chen,G., Katneni,K., Klemm,T.A., Nachbur,U., Georgy,S.R., Czabotar,P.E., Hannan,A.J., Putoczki,T.L., Tanzer,M., Pellegrini,M., Lechtenberg,B.C., Charman,S.A., Call,M.J., Mitchell,J.P., Lowes,K.N., Lessene,G., Doerflinger,M. and Komander,D.
    A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
    Nat Commun16, 2900-2900. PubMed  Europe PubMed DOI
  2. De Falco,A., Greene-Cramer,R., Surina,B.A., Zakian,S., Acton,T.B., Ramelot,T.A. and Montelione,G.T.
    From Plasmid to Pure Protein: Production and Characterization of SARS-CoV-2 PL (pro)
    bioRxiv PubMed  Europe PubMed DOI
  3. Gu,X., Zhang,X., Zhang,X., Wang,X., Sun,W., Zhang,Y. and Hu,Z.
    Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
    Nat Prod Bioprospect15, 3-3. PubMed  Europe PubMed DOI  I
  4. Jadhav,P., Liang,X., Ansari,A., Tan,B., Tan,H., Li,K., Chi,X., Ford,A., Ruiz,F.X., Arnold,E., Deng,X. and Wang,J.
    Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates
    Nat Commun16, 1604-1604. PubMed  Europe PubMed DOI  I
  5. Li,K., Jadhav,P., Wen,Y., Tan,H. and Wang,J.
    Development of a Fluorescence Polarization Assay for the SARS-CoV-2 Papain-like Protease
    ACS Pharmacol Transl Sci8, 774-784. PubMed  Europe PubMed DOI
    6. 2024
  6. Akasov,R.A., Chepikova,O.E., Pallaeva,T.N., Gorokhovets,N.V., Siniavin,A.E., Gushchin,V.A., Savvateeva,L.V., Vinokurov,I.A., Khochenkov,D.A., Zamyatnin,A.A., Jr. and Khaydukov,E.V.
    Evaluation of molecular mechanisms of riboflavin anti-COVID-19 action reveals anti-inflammatory efficacy rather than antiviral activity
    Biochim Biophys Acta Gen Subj1868, 130582-130582. PubMed  Europe PubMed DOI
  7. Armstrong,L.A., Lange,S.M., Cesare,V., Matthews,S.P., Nirujogi,R.S., Cole,I., Hope,A., Cunningham,F., Toth,R., Mukherjee,R., Bojkova,D., Gruber,F., Gray,D., Wyatt,P.G., Cinatl,J., Dikic,I., Davies,P. and Kulathu,Y.
    Correction: Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
    PLoS ONE19, e0302418-e0302418. PubMed  Europe PubMed DOI
  8. Cesar Ramos de Jesus,H., Solis,N., Machado,Y., Pablos,I., Bell,P.A., Kappelhoff,R., Grin,P.M., Sorgi,C.A., Butler,G.S. and Overall,C.M.
    Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL(pro) main protease (Mpro) from proteomic identification of P6-P6' active site specificity
    J Virole0004924-e0004924. PubMed  Europe PubMed DOI
  9. Chan,H.T.H., Brewitz,L., Lukacik,P., Strain-Damerell,C., Walsh,M.A., Schofield,C.J. and Duarte,F.
    Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein
    RSC Chem Biol5, 117-130. PubMed  Europe PubMed DOI
  10. Cho,B.H., Kim,J. and Jang,Y.S.
    The Papain-like Protease Domain of Severe Acute Respiratory Syndrome Coronavirus 2 Conjugated with Human Beta-Defensin 2 and Co1 Induces Mucosal and Systemic Immune Responses against the Virus
    Vaccines (Basel)12, PubMed  Europe PubMed DOI
  11. Ciaglia,T., Vestuto,V., Di Sarno,V., Musella,S., Smaldone,G., Di Matteo,F., Napolitano,V., Miranda,M.R., Pepe,G., Basilicata,M.G., Novi,S., Capolupo,I., Bifulco,G., Campiglia,P., Gomez-Monterrey,I., Snoeck,R., Andrei,G., Manfra,M., Ostacolo,C., Lauro,G. and Bertamino,A.
    Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization
    Eur J Med Chem266, 116128-116128. PubMed  Europe PubMed DOI  I
  12. Diogo,M.A., Cabral,A.G.T. and de Oliveira,R.B.
    Advances in the Search for SARS-CoV-2 M(pro) and PL(pro) Inhibitors
    Pathogens13, PubMed  Europe PubMed DOI  V
  13. Jadhav,P., Huang,B., Osipiuk,J., Zhang,X., Tan,H., Tesar,C., Endres,M., Jedrzejczak,R., Tan,B., Deng,X., Joachimiak,A., Cai,J. and Wang,J.
    Structure-based design of SARS-CoV-2 papain-like protease inhibitors
    Eur J Med Chem264, 116011-116011. PubMed  Europe PubMed DOI  I
  14. Kerti,L. and Frecer,V.
    Design of inhibitors of SARS-CoV-2 papain-like protease deriving from GRL0617: Structure-activity relationships
    Bioorg Med Chem113, 117909-117909. PubMed  Europe PubMed DOI  V  I
  15. Kiba,Y., Tanikawa,T. and Kitamura,M.
    Ciclesonide Inhibits SARS-CoV-2 Papain-Like Protease in Vitro
    Biol Pharm Bull47, 965-966. PubMed  Europe PubMed DOI  I
  16. Li,M., Bei,Z.C., Yuan,Y., Wang,B., Zhang,D., Xu,L., Zhao,L., Xu,Q. and Song,Y.
    In-cell bioluminescence resonance energy transfer (BRET)-based assay uncovers ceritinib and CA-074 as SARS-CoV-2 papain-like protease inhibitors
    J Enzyme Inhib Med Chem39, 2387417-2387417. PubMed  Europe PubMed DOI  I
  17. Li,X. and Song,Y.
    Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery
    Drug Discov Today29, 103832-103832. PubMed  Europe PubMed DOI  V
  18. Lu,Y., Yang,Q., Ran,T., Zhang,G., Li,W., Zhou,P., Tang,J., Dai,M., Zhong,J., Chen,H., He,P., Zhou,A., Xue,B., Chen,J., Zhang,J., Yang,S., Wu,K., Wu,X., Tang,M., Zhang,W.K., Guo,D., Chen,X., Chen,H. and Shang,J.
    Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19
    Nat Commun15, 10169-10169. PubMed  Europe PubMed DOI  I
  19. Patel,D.K., Kumar,H. and Sobhia,M.E.
    Exploring the binding dynamics of covalent inhibitors within active site of PL(pro) in SARS-CoV-2
    Comput Biol Chem112, 108132-108132. PubMed  Europe PubMed DOI
  20. Rhamadianti,A.F., Abe,T., Tanaka,T., Ono,C., Katayama,H., Makino,Y., Deng,L., Matsui,C., Moriishi,K., Shima,F., Matsuura,Y. and Shoji,I.
    SARS-CoV-2 papain-like protease inhibits ISGylation of the viral nucleocapsid protein to evade host anti-viral immunity
    J Virole0085524-e0085524. PubMed  Europe PubMed DOI
  21. Shen,S., Guo,H., Li,Y., Zhang,L., Tang,Y., Li,H., Li,X., Wang,P.H., Yu,X.F. and Wei,W.
    SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis
    J Virol98, e0190923-e0190923. PubMed  Europe PubMed DOI
  22. Shinohara,K., Kobayakawa,T., Tsuji,K., Takamatsu,Y., Mitsuya,H. and Tamamura,H.
    Naphthalen-1-ylethanamine-containing small molecule inhibitors of the papain-like protease of SARS-CoV-2
    Eur J Med Chem280, 116963-116963. PubMed  Europe PubMed DOI
  23. Tan,B., Zhang,X., Ansari,A., Jadhav,P., Tan,H., Li,K., Chopra,A., Ford,A., Chi,X., Ruiz,F.X., Arnold,E., Deng,X. and Wang,J.
    Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
    Science383, 1434-1440. PubMed  Europe PubMed DOI
  24. Tan,B., Liang,X., Ansari,A., Jadhav,P., Tan,H., Li,K., Ruiz,F.X., Arnold,E., Deng,X. and Wang,J.
    Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors
    J Med Chem PubMed  Europe PubMed DOI
  25. Taylor,A.J., Amporndanai,K., Rietz,T.A., Zhao,B., Thiruvaipati,A., Wei,Q., South,T.M., Crow,M.M., Apakama,C., Sensintaffar,J.L., Phan,J., Lee,T. and Fesik,S.W.
    Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL(pro))
    ACS Med Chem Lett15, 1351-1357. PubMed  Europe PubMed DOI
    26. 2023
  26. Bello,S.O., Imam,M.U., Bello,M.B., Yunusa,A., Ahmed Adamu,A., Shuaibu,A., Igumbor,E.U., Habib,Z.G., Popoola,M.A., Ochu,C.L., Yahaya Bello,A., Deeni,Y.Y. and Okoye,I.
    Erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin inhibit cytopathic effect, papain-like protease, and M(PRO) enzymes of SARS-CoV-2
    Front Cell Infect Microbiol13, 1273982-1273982. PubMed  Europe PubMed DOI  I
  27. Brewitz,L., Henry Chan,H.T., Lukacik,P., Strain-Damerell,C., Walsh,M.A., Duarte,F. and Schofield,C.J.
    Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification
    Bioorg Med Chem95, 117498-117498. PubMed  Europe PubMed DOI
  28. Brian Chia,C.S. and Pheng Lim,S.
    A Patent Review on SARS Coronavirus Papain-Like Protease (PL(pro) ) Inhibitors
    ChemMedChem18, e202300216-e202300216. PubMed  Europe PubMed DOI  V
  29. Chang,J., Kim,J., Hong,S., Jeong,K., Kim,S. and Lee,W.
    Protocol for in vitro fluorescence assay of papain-like protease and cell-based immunofluorescence assay of coronavirus infection
    STAR Protoc4, 102295-102295. PubMed  Europe PubMed DOI
  30. Duan,L., Tang,B., Luo,S., Xiong,D., Wang,Q., Xu,X. and Zhang,J.Z.H.
    Entropy driven cooperativity effect in multi-site drug optimization targeting SARS-CoV-2 papain-like protease
    Cell Mol Life Sci80, 313-313. PubMed  Europe PubMed DOI
  31. Ghosh,A.K., Shahabi,D., Imhoff,M.E.C., Kovela,S., Sharma,A., Hattori,S.I., Higashi-Kuwata,N., Mitsuya,H. and Mesecar,A.D.
    SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads
    Bioorg Med Chem Lett96, 129489-129489. PubMed  Europe PubMed DOI
  32. He,Z., Yuan,J., Zhang,Y., Li,R., Mo,M., Wang,Y. and Ti,H.
    Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets
    Pharm Biol61, 1186-1210. PubMed  Europe PubMed DOI  V
  33. Kattula,B., Reddi,B., Jangam,A., Naik,L., Adimoolam,B.M., Vavilapalli,S., Are,S., Thota,J.R., Jadav,S.S., Arifuddin,M. and Addlagatta,A.
    Development of 2-chloroquinoline based heterocyclic frameworks as dual inhibitors of SARS-CoV-2 M(Pro) and PL(Pro)
    Int J Biol Macromol242, 124772-124772. PubMed  Europe PubMed DOI  I
  34. Kosenko,M., Onkhonova,G., Susloparov,I. and Ryzhikov,A.
    SARS-CoV-2 proteins structural studies using synchrotron radiation
    Biophys Rev15, 1185-1194. PubMed  Europe PubMed DOI
  35. Liang,Q., Huang,Y., Wang,M., Kuang,D., Yang,J., Yi,Y., Shi,H., Li,J., Yang,J. and Li,G.
    An electrochemical biosensor for SARS-CoV-2 detection via its papain-like cysteine protease and the protease inhibitor screening
    Chem Eng J452, 139646-139646. PubMed  Europe PubMed DOI
  36. Moghadasi,S.A., Heilmann,E., Khalil,A.M., Nnabuife,C., Kearns,F.L., Ye,C., Moraes,S.N., Costacurta,F., Esler,M.A., Aihara,H., von Laer,D., Martinez-Sobrido,L., Palzkill,T., Amaro,R.E. and Harris,R.S.
    Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
    Sci Adv9, eade8778-eade8778. PubMed  Europe PubMed DOI
  37. Shao,Q., Xiong,M., Li,J., Hu,H., Su,H. and Xu,Y.
    Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches
    Chem Sci14, 4681-4696. PubMed  Europe PubMed DOI
  38. Tan,H., Hu,Y. and Wang,J.
    FlipGFP protease assay for evaluating in vitro inhibitory activity against SARS-CoV-2 M(pro) and PL(pro)
    STAR Protoc4, 102323-102323. PubMed  Europe PubMed DOI
  39. Wang,Q., Chen,G., He,J., Li,J., Xiong,M., Su,H., Li,M., Hu,H. and Xu,Y.
    Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  40. Wu,Y., Pegan,S.D., Crich,D., Lou,L., Mullininx,L.N., Starling,E.B., Booth,C., Chishom,A.E., Chang,K.Y. and Xie,Z.R.
    Identifying Drug Candidates for COVID-19 with Large-Scale Drug Screening
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  41. Yang,M., Mariano,J., Su,R., Smith,C.E., Das,S., Gill,C., Andresson,T., Loncarek,J., Tsai,Y.C. and Weissman,A.M.
    SARS-CoV-2 papain-like protease plays multiple roles in regulating cellular proteins in the endoplasmic reticulum
    J Biol Chem299, 105346-105346. PubMed  Europe PubMed DOI
  42. Yevsieieva,L.V., Lohachova,K.O., Kyrychenko,A., Kovalenko,S.M., Ivanov,V.V. and Kalugin,O.N.
    Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2
    RSC Adv13, 35500-35524. PubMed  Europe PubMed DOI  V
  43. Zhao,K., Li,Y., Guo,M., Ma,L. and Dang,B.
    Identification of SARS-CoV-2 PLpro and 3CLpro human proteome substrates using substrate phage display coupled with protein network analysis
    J Biol Chem299, 104831-104831. PubMed  Europe PubMed DOI
    44. 2022
  44. Hu,H., Wang,Q., Su,H., Shao,Q., Zhao,W., Chen,G., Li,M. and Xu,Y.
    Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease
    Angew Chem Int Ed Engl61, e202212378-e202212378. PubMed  Europe PubMed DOI
  45. Jiang,H., Yang,P. and Zhang,J.
    Potential Inhibitors Targeting Papain-Like Protease of SARS-CoV-2: Two Birds With One Stone
    Front Chem10, 822785-822785. PubMed  Europe PubMed DOI  V
  46. Kladnik,J., Dolinar,A., Kljun,J., Perea,D., Grau-Exposito,J., Genesca,M., Novinec,M., Buzon,M.J. and Turel,I.
    Zinc pyrithione is a potent inhibitor of PL(Pro) and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication
    J Enzyme Inhib Med Chem37, 2158-2168. PubMed  Europe PubMed DOI
  47. Majerova,T. and Konvalinka,J.
    Viral proteases as therapeutic targets
    Mol Aspects Med88, 101159-101159. PubMed  Europe PubMed DOI  V  I
  48. Meewan,I., Kattoula,J., Kattoula,J.Y., Skinner,D., Fajtova,P., Giardini,M.A., Woodworth,B., McKerrow,J.H., Lage de Siqueira-Neto,J., O'Donoghue,A.J. and Abagyan,R.
    Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
    Pharmaceuticals (Basel)15, PubMed  Europe PubMed DOI  I
  49. Narayanan,A., Toner,S.A. and Jose,J.
    Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases
    Biochem Soc Trans50, 151-165. PubMed  Europe PubMed DOI
  50. Oki,N., Yamada,S., Tanaka,T., Fukui,H., Hatakeyama,S. and Okumura,F.
    Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylation
    Biochem Biophys Res Commun625, 94-101. PubMed  Europe PubMed DOI  I
  51. Rieder,A.S., Deniz,B.F., Netto,C.A. and Wyse,A.T.S.
    A Review of In Silico Research, SARS-CoV-2, and Neurodegeneration: Focus on Papain-Like Protease
    Neurotox Res40, 1553-1569. PubMed  Europe PubMed DOI  V
  52. Shetler,C.L., Ferreira,J.C., Cardoso,T.H.S., Silva,E.M.A., Saksena,N.K. and Rabeh,W.M.
    Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2
    Biochem J479, 2175-2193. PubMed  Europe PubMed DOI
  53. Tan,H., Hu,Y., Jadhav,P., Tan,B. and Wang,J.
    Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease
    J Med Chem65, 7561-7580. PubMed  Europe PubMed DOI
  54. Tan,J., Wu,Z., Hu,P., Gan,L., Wang,Y. and Zhang,D.
    Association between Mutations in Papain-like Protease (PLpro) of SARS-CoV-2 with COVID-19 Clinical Outcomes
    Pathogens11, PubMed  Europe PubMed DOI
  55. Ullrich,S. and Nitsche,C.
    SARS-CoV-2 Papain-Like Protease: Structure, Function and Inhibition
    Chembiochem23, e202200327-e202200327. PubMed  Europe PubMed DOI  V
  56. Yan,H., Liu,Z., Yan,G., Liu,X., Liu,X., Wang,Y. and Chen,Y.
    A robust high-throughput fluorescence polarization assay for rapid screening of SARS-CoV-2 papain-like protease inhibitors
    Virology574, 18-24. PubMed  Europe PubMed DOI
  57. Yuan,S., Gao,X., Tang,K., Cai,J.P., Hu,M., Luo,P., Wen,L., Ye,Z.W., Luo,C., Tsang,J.O., Chan,C.C., Huang,Y., Cao,J., Liang,R., Qin,Z., Qin,B., Yin,F., Chu,H., Jin,D.Y., Sun,R., Chan,J.F., Cui,S. and Yuen,K.Y.
    Targeting papain-like protease for broad-spectrum coronavirus inhibition
    Protein Cell13, 940-953. PubMed  Europe PubMed DOI
  58. Zapata-Cardona,M.I., Florez-Alvarez,L., Zapata-Builes,W., Guerra-Sandoval,A.L., Guerra-Almonacid,C.M., Hincapie-Garcia,J., Rugeles,M.T. and Hernandez,J.C.
    Atorvastatin Effectively Inhibits Ancestral and Two Emerging Variants of SARS-CoV-2 in vitro
    Front Microbiol13, 721103-721103. PubMed  Europe PubMed DOI
    59. 2021
  59. Alabbas,A.B. and Alamri,M.A.
    Analyzing the Effect of Mutations in SARS-CoV2 Papain-Like Protease from Saudi Isolates on Protein Structure and Drug-Protein Binding: Molecular Modelling and Dynamics Studies
    Saudi J Biol Sci PubMed  Europe PubMed DOI
  60. Amin,S.A., Banerjee,S., Gayen,S. and Jha,T.
    Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?
    Eur J Med Chem215, 113294-113294. PubMed  Europe PubMed DOI
  61. Ayipo,Y.O., Yahaya,S.N., Alananzeh,W.A., Babamale,H.F. and Mordi,M.N.
    Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside
    Infect Genet Evol93, 104944-104944. PubMed  Europe PubMed DOI  V  I
  62. Bhowmik,D., Sharma,R.D., Prakash,A. and Kumar,D.
    Identification of Nafamostat and VR23 as COVID-19 drug candidates by targeting 3CL(pro) and PL(pro)
    J Mol Struct1233, 130094-130094. PubMed  Europe PubMed DOI  I
  63. Hariyono,P., Patramurti,C., Candrasari,D.S. and Hariono,M.
    An integrated virtual screening of compounds from Carica papaya leaves against multiple protein targets of SARS-Coronavirus-2
    Results Chem3, 100113-100113. PubMed  Europe PubMed DOI
  64. Jamalan,M., Barzegari,E. and Gholami-Borujeni,F.
    Structure-Based Screening to Discover New Inhibitors for Papain-like Proteinase of SARS-CoV-2: An In Silico Study
    J Proteome Res20, 1015-1026. PubMed  Europe PubMed DOI
  65. Kumar,A., Loharch,S., Kumar,S., Ringe,R.P. and Parkesh,R.
    Exploiting cheminformatic and machine learning to navigate the available chemical space of potential small molecule inhibitors of SARS-CoV-2
    Comput Struct Biotechnol J19, 424-438. PubMed  Europe PubMed DOI  I
  66. Kuo,C.J., Chao,T.L., Kao,H.C., Tsai,Y.M., Liu,Y.K., Wang,L.H., Hsieh,M.C., Chang,S.Y. and Liang,P.H.
    Kinetic characterization and inhibitor screening for the proteases leading to identification of drugs against SARS-CoV-2
    Antimicrob Agents Chemother PubMed  Europe PubMed DOI
  67. Lim,C.T., Tan,K.W., Wu,M., Ulferts,R., Armstrong,L.A., Ozono,E., Drury,L.S., Milligan,J.C., Zeisner,T.U., Zeng,J., Weissmann,F., Canal,B., Bineva-Todd,G., Howell,M., O'Reilly,N., Beale,R., Kulathu,Y., Labib,K. and Diffley,J.F.X.
    Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease
    Biochem J478, 2517-2531. PubMed  Europe PubMed DOI
  68. Liu,G., Lee,J.H., Parker,Z.M., Acharya,D., Chiang,J.J., van Gent,M., Riedl,W., Davis-Gardner,M.E., Wies,E., Chiang,C. and Gack,M.U.
    ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
    Nat Microbiol6, 467-478. PubMed  Europe PubMed DOI
  69. Lv,Z., Cano,K.E., Jia,L., Drag,M., Huang,T.T. and Olsen,S.K.
    Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development
    Front Chem9, 819165-819165. PubMed  Europe PubMed DOI  V
  70. Meyer,B., Chiaravalli,J., Gellenoncourt,S., Brownridge,P., Bryne,D.P., Daly,L.A., Grauslys,A., Walter,M., Agou,F., Chakrabarti,L.A., Craik,C.S., Eyers,C.E., Eyers,P.A., Gambin,Y., Jones,A.R., Sierecki,E., Verdin,E., Vignuzzi,M. and Emmott,E.
    Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
    Nat Commun12, 5553-5553. PubMed  Europe PubMed DOI  K
  71. Mohamud,Y., Xue,Y.C., Liu,H., Ng,C.S., Bahreyni,A., Jan,E. and Luo,H.
    The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy
    Biochem Biophys Res Commun540, 75-82. PubMed  Europe PubMed DOI
  72. Rajpoot,S., Alagumuthu,M. and Baig,M.S.
    Dual targeting of 3CL(pro) and PL(pro) of SARS-CoV-2: A novel structure-based design approach to treat COVID-19
    Curr Res Struct Biol3, 9-18. PubMed  Europe PubMed DOI
  73. Reynolds,N.D., Aceves,N.M., Liu,J.L., Compton,J.R., Leary,D.H., Freitas,B.T., Pegan,S.D., Doctor,K.Z., Wu,F.Y., Hu,X. and Legler,P.M.
    The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease
    ACS Infect Dis7, 1483-1502. PubMed  Europe PubMed DOI
  74. Shah,A., Patel,V. and Parmar,B.
    Discovery of Some Antiviral Natural products to fight against Novel Corona Virus (SARS-CoV-2) using Insilico approach
    Comb Chem High Throughput Screen24, 1271-1280. PubMed  Europe PubMed DOI  I
  75. Sharma,A., Kaliya,K. and Maurya,S.K.
    Recent Advances in Discovery of Potent Proteases Inhibitors Targeting the SARS Coronaviruses
    Curr Top Med Chem21, 307-328. PubMed  Europe PubMed DOI  V
  76. Sivakumar,D. and Stein,M.
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