Literature for peptidase C14.044: metacaspase TbMCA2

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Duarte,A.C.M., de Oliveira,V.H., Costa,J.P.M.S., Trujilho,M.N.R., de Souza Judice,W.A. and Machado,M.F.M. Calcium dependence and biochemical characterization of metacaspase-3 from Trypanosoma cruzi Biochim Biophys Acta Proteins Proteom (2026) 1874, 141122-141122. PubMed Europe PubMed DOI

2024

Araujo,L.H., Bueno Chagas,T.A., Reis,T., de Morais Borba,J.R.B., Trujilho,M.N.R., Dalzoto,L.A.M., Marcondes,M.F., Juliano,M.A., Judice,W.A.S., Veloso,M.P. and Machado,M.F.M. Oximic compounds as potential inhibitors of metacaspase-2 (TbMCA2) of Trypanosoma brucei Biochem Biophys Res Commun (2024) 735, 150657-150657. PubMed Europe PubMed DOI I

2020

Eyssen,L.E. and Coetzer,T.H. Validation of ligands targeting metacaspase-2 (MCA2) from Trypanosoma brucei brucei and their application to MCA5 from T. congolense as possible trypanocides J Mol Graph Model (2020) 97, 107579-107579. PubMed Europe PubMed DOI

2017

De Castro,E., Reus,T.L., de Aguiar,A.M., Avila,A.R. and de Arruda Campos Brasil de Souza,T. Procaspase-activating compound-1 induces apoptosis in Trypanosoma cruzi Apoptosis (2017) 22, 1564-1577. PubMed Europe PubMed DOI
Gilio,J.M., Marcondes,M.F., Ferrari,D., Juliano,M.A., Juliano,L., Oliveira,V. and Machado,M.F. Processing of metacaspase 2 from Trypanosoma brucei (TbMCA2) broadens its substrate specificity Biochim Biophys Acta (2017) 1865, 388-394. PubMed Europe PubMed DOI

2013

Machado,M.F., Marcondes,M.F., Juliano,M.A., McLuskey,K., Mottram,J.C., Moss,C.X., Juliano,L. and Oliveira,V. Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2 FEBS J (2013) 280, 2608-2621. PubMed Europe PubMed DOI P

2012

Laverriere,M., Cazzulo,J.J. and Alvarez,V.E. Antagonic activities of Trypanosoma cruzi metacaspases affect the balance between cell proliferation, death and differentiation Cell Death Differ (2012) 19, 1358-1369. PubMed Europe PubMed DOI
McLuskey,K., Rudolf,J., Proto,W.R., Isaacs,N.W., Coombs,G.H., Moss,C.X. and Mottram,J.C. Crystal structure of a Trypanosoma brucei metacaspase Proc Natl Acad Sci U S A (2012) 109, 7469-7474. PubMed Europe PubMed DOI S

2011

Meslin,B., Zalila,H., Fasel,N., Picot,S. and Bienvenu,A.L. Are protozoan metacaspases potential parasite killers? Parasit Vectors (2011) 4, 26-26. PubMed Europe PubMed DOI PMC EPMC
Tsiatsiani,L., Van Breusegem,F., Gallois,P., Zavialov,A., Lam,E. and Bozhkov,P.V. Metacaspases Cell Death Differ (2011) 18, 1279-1288. PubMed Europe PubMed DOI V

2010

Berg,M., Van der Veken,P., Joossens,J., Muthusamy,V., Breugelmans,M., Moss,C.X., Rudolf,J., Cos,P., Coombs,G.H., Maes,L., Haemers,A., Mottram,J.C. and Augustyns,K. Design and evaluation of Trypanosoma brucei metacaspase inhibitors Bioorg Med Chem Lett (2010) 20, 2001-2006. PubMed Europe PubMed DOI I

2007

Moss,C.X., Westrop,G.D., Juliano,L., Coombs,G.H. and Mottram,J.C. Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing FEBS Lett (2007) 581, 5635-5639. PubMed Europe PubMed DOI

2006

[YEAR:15-3-2006]Helms,M.J., Ambit,A., Appleton,P., Tetley,L., Coombs,G.H. and Mottram,J.C. Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes J Cell Sci (15-3-2006) 119, 1105-1117. PubMed Europe PubMed DOI
[YEAR:23-9-2006]Kosec,G., Alvarez,V.E., Aguero,F., Sanchez,D., Dolinar,M., Turk,B., Turk,V. and Cazzulo,J.J. Metacaspases of Trypanosoma cruzi: possible candidates for programmed cell death mediators Mol Biochem Parasitol (23-9-2006) 145, 18-28. PubMed Europe PubMed DOI
Kosec,G., Alvarez,V. and Cazzulo,J.J. Cysteine proteinases of Trypanosoma cruzi: from digestive enzymes to programmed cell death mediators Biocell (2006) 30, 479-490. PubMed Europe PubMed