Literature for peptidase C14.019: caspase DRONC (Drosophila melanogaster)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Tian,L., Li,Y. and Shi,Y.
    Dark and Dronc activation in Drosophila melanogaster
    Proc Natl Acad Sci U S A121, e2312784121-e2312784121. PubMed  Europe PubMed DOI
  2. 2023
  3. Kietz,C. and Meinander,A.
    Drosophila caspases as guardians of host-microbe interactions
    Cell Death Differ30, 227-236. PubMed  Europe PubMed DOI  V
  4. Park,J.E., Lee,J., Ok,S., Byun,S., Chang,E.J., Yoon,S.E., Kim,Y.J. and Kang,M.J.
    Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model
    Exp Mol Med55, 1544-1555. PubMed  Europe PubMed DOI
  5. 2022
  6. Farrell,L., Puig-Barbe,A., Haque,M.I., Amcheslavsky,A., Yu,M., Bergmann,A. and Fan,Y.
    Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation
    PLoS Genet18, e1010533-e1010533. PubMed  Europe PubMed DOI
  7. Yarikipati,P. and Bergmann,A.
    In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening
    J Vis Exp PubMed  Europe PubMed DOI
  8. 2021
  9. Lindblad,J.L., Tare,M., Amcheslavsky,A., Shields,A. and Bergmann,A.
    Non-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestine
    Sci Rep11, 2645-2645. PubMed  Europe PubMed DOI  K
  10. Wada,Y., Ohsawa,S. and Igaki,T.
    Yorkie ensures robust tissue growth in Drosophila ribosomal protein mutants
    Development148, PubMed  Europe PubMed DOI
  11. 2020
  12. Amcheslavsky,A., Lindblad,J.L. and Bergmann,A.
    Transiently "Undead" Enterocytes Mediate Homeostatic Tissue Turnover in the Adult Drosophila Midgut
    Cell Rep33, 108408-108408. PubMed  Europe PubMed DOI
  13. Arthurton,L., Nahotko,D.A., Alonso,J., Wendler,F. and Baena-Lopez,L.A.
    Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence
    EMBO Repe48892-e48892. PubMed  Europe PubMed DOI
  14. Chowdhury,A., Modahl,C.M., Tan,S.T., Wong Wei Xiang,B., Misse,D., Vial,T., Kini,R.M. and Pompon,J.F.
    JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands
    PLoS Pathog16, e1008754-e1008754. PubMed  Europe PubMed DOI
  15. 2017
  16. Jo,J., Im,S.H., Babcock,D.T., Iyer,S.C., Gunawan,F., Cox,D.N. and Galko,M.J.
    Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization
    Cell Death Dis8, e2786-e2786. PubMed  Europe PubMed DOI
  17. Kamber Kaya,H.E., Ditzel,M., Meier,P. and Bergmann,A.
    An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways
    PLoS Genet13, e1006438-e1006438. PubMed  Europe PubMed DOI
  18. Khan,C., Muliyil,S., Ayyub,C. and Rao,B.J.
    The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster
    J Cell Sci130, 2984-2995. PubMed  Europe PubMed DOI
  19. 2016
  20. Lee,T.V., Kamber Kaya,H.E., Simin,R., Baehrecke,E.H. and Bergmann,A.
    The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila
    Cell Death Differ23, 1555-1564. PubMed  Europe PubMed DOI
  21. 2015
  22. Kale,A., Li,W., Lee,C.H. and Baker,N.E.
    Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica
    Cell Death Differ22, 1300-1312. PubMed  Europe PubMed DOI
  23. 2014
  24. Ming,M., Obata,F., Kuranaga,E. and Miura,M.
    Persephone/Spatzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila
    J Biol Chem289, 7558-7568. PubMed  Europe PubMed DOI  K
  25. 2013
  26. Huang,N., Civciristov,S., Hawkins,C.J. and Clem,R.J.
    SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda
    Insect Biochem Mol Biol43, 444-454. PubMed  Europe PubMed DOI
  27. Kitaguchi,K., Hamajima,R., Yamada,H., Kobayashi,M. and Ikeda,M.
    Transient expression assay reveals kinetic difference in the proteolytic processing between Dronc proteins from the gypsy moth Lymantria dispar and the silkworm Bombyx mori
    J Insect Biotechnol Sericology82, 49-54. DOI
  28. Yamada,H., Kitaguchi,K., Hamajima,R., Kobayashi,M. and Ikeda,M.
    Novel apoptosis suppressor Apsup from the baculovirus Lymantria dispar multiple nucleopolyhedrovirus precludes apoptosis by preventing proteolytic processing of initiator caspase Dronc
    J Virol87, 12925-12934. PubMed  Europe PubMed DOI
  29. Zhang,J.Y., Xu,W., Pan,C., Yi,H.S., Hu,Y.F., Song,J., Pan,M.H. and Lu,C.
    Cloning and characterization of the caspase family member bmdronc from Bombyx mori (Lepidoptera: Bombycidae) embryo cells
    Ann Entomol Soc Am106, 265-272. DOI
  30. 2012
  31. Dorstyn,L. and Kumar,S.
    Insect caspases
    [ISSN:978-0-12-407743-0]3, 2286-2295. DOI
  32. Verghese,S., Bedi,S. and Kango-Singh,M.
    Hippo signalling controls Dronc activity to regulate organ size in Drosophila
    Cell Death Differ19, 1664-1676. PubMed  Europe PubMed DOI
  33. 2011
  34. Khammari,A., Agnes,F., Gandille,P. and Pret,A.M.
    Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1
    Cell Death Differ18, 793-805. PubMed  Europe PubMed DOI
  35. Lee,G., Wang,Z., Sehgal,R., Chen,C.H., Kikuno,K., Hay,B. and Park,J.H.
    Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis
    J Comp Neurol519, 34-48. PubMed  Europe PubMed DOI
  36. Lee,T.V., Fan,Y., Wang,S., Srivastava,M., Broemer,M., Meier,P. and Bergmann,A.
    Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation
    PLoS Genet7, e1002261-e1002261. PubMed  Europe PubMed DOI
  37. Ouyang,Y., Petritsch,C., Wen,H., Jan,L., Jan,Y.N. and Lu,B.
    Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila
    Development138, 2185-2196. PubMed  Europe PubMed DOI
  38. Suganuma,I., Ushiyama,T., Yamada,H., Iwamoto,A., Kobayashi,M. and Ikeda,M.
    Cloning and characterization of a dronc homologue in the silkworm, Bombyx mori
    Insect Biochem Mol Biol41, 909-921. PubMed  Europe PubMed DOI
  39. 2010
  40. Fan,Y. and Bergmann,A.
    The cleaved-caspase-3 antibody is a marker of caspase-9-like DRONC activity in Drosophila
    Cell Death Differ17, 534-539. PubMed  Europe PubMed DOI
  41. Yang,C.S., Thomenius,M.J., Gan,E.C., Tang,W., Freel,C.D., Merritt,T.J., Nutt,L.K. and Kornbluth,S.
    Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc
    EMBO J29, 3196-3207. PubMed  Europe PubMed DOI
  42. 2008
  43. Dorstyn,L. and Kumar,S.
    A biochemical analysis of the activation of the Drosophila caspase DRONC
    Cell Death Differ15, 461-470. PubMed  Europe PubMed DOI
  44. Snipas,S.J., Drag,M., Stennicke,H.R. and Salvesen,G.S.
    Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC
    Cell Death Differ15, 938-945. PubMed  Europe PubMed DOI  P
  45. 2007
  46. Baum,J.S., Arama,E., Steller,H. and McCall,K.
    The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis
    Cell Death Differ14, 1508-1517. PubMed  Europe PubMed DOI
  47. Cooper,D.M., Thi,E.P., Chamberlain,C.M., Pio,F. and Lowenberger,C.
    Aedes Dronc: a novel ecdysone-inducible caspase in the yellow fever mosquito, Aedes aegypti
    Insect Mol Biol16, 563-572. PubMed  Europe PubMed DOI
  48. 2006
  49. Kondo,S., Senoo-Matsuda,N., Hiromi,Y. and Miura,M.
    DRONC coordinates cell death and compensatory proliferation
    Mol Cell Biol26, 7258-7268. PubMed  Europe PubMed DOI
  50. [YEAR:30-1-2006]Yan,N., Huh,J.R., Schirf,V., Demeler,B., Hay,B.A. and Shi,Y.
    Structure and activation mechanism of the Drosophila initiator caspase Dronc
    J Biol Chem281, 8667-8674. PubMed  Europe PubMed DOI  S
  51. 2005
  52. Mills,K., Daish,T. and Kumar,S.
    The function of the Drosophila caspase DRONC in cell death and development
    Cell Cycle4, 744-746. PubMed  Europe PubMed
  53. [YEAR:17-3-2005]Muro,I., Means,J.C. and Clem,R.J.
    Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells
    J Biol Chem280, 18683-18688. PubMed  Europe PubMed DOI
  54. [YEAR:25-5-2005]Waldhuber,M., Emoto,K. and Petritsch,C.
    The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals
    Mech Dev122, 914-927. PubMed  Europe PubMed DOI
  55. Xu,D., Li,Y., Arcaro,M., Lackey,M. and Bergmann,A.
    The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
    Development132, 2125-2134. PubMed  Europe PubMed DOI
  56. 2004
  57. Chew,S.K., Akdemir,F., Chen,P., Lu,W.J., Mills,K., Daish,T., Kumar,S., Rodriguez,A. and Abrams,J.M.
    The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila
    Dev Cell7, 897-907. PubMed  Europe PubMed DOI  K
  58. Daish,T.J., Mills,K. and Kumar,S.
    Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis
    Dev Cell7, 909-915. PubMed  Europe PubMed DOI  K
  59. [YEAR:27-7-2004]Huh,J.R., Guo,M. and Hay,B.A.
    Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase dronc in a nonapoptotic role
    Curr Biol14, 1262-1266. PubMed  Europe PubMed DOI
  60. Kumar,S.
    Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical "apoptotic caspase"
    Sci STKE2004, e49-e49. PubMed  Europe PubMed DOI
  61. Muro,I., Monser,K. and Clem,R.J.
    Mechanism of Dronc activation in Drosophila cells
    J Cell Sci117, 5035-5041. PubMed  Europe PubMed DOI
  62. 2003
  63. Chai,J., Yan,N., Huh,J.R., Wu,J.W., Li,W., Hay,B.A. and Shi,Y.
    Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
    Nat Struct Biol10, 892-898. PubMed  Europe PubMed DOI
  64. [YEAR:29-8-2003]Daish,T.J., Cakouros,D. and Kumar,S.
    Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc
    Cell Death Differ10, 1348-1356. PubMed  Europe PubMed DOI
  65. 2002
  66. [YEAR:10-6-2002]Cakouros,D., Daish,T., Martin,D., Baehrecke,E.H. and Kumar,S.
    Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex
    J Cell Biol157, 985-995. PubMed  Europe PubMed DOI
  67. Igaki,T., Yamamoto-Goto,Y., Tokushige,N., Kanda,H. and Miura,M.
    Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC
    J Biol Chem277, 23103-23106. PubMed  Europe PubMed DOI
  68. [YEAR:20-12-2002]Muro,I., Hay,B.A. and Clem,R.J.
    The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
    J Biol Chem277, 49644-49650. PubMed  Europe PubMed DOI  I
  69. Wilson,R., Goyal,L., Ditzel,M., Zachariou,A., Baker,D.A., Agapite,J., Steller,H. and Meier,P.
    The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
    Nat Cell Biol4, 445-450. PubMed  Europe PubMed DOI
  70. Yu,S.Y., Yoo,S.J., Yang,L., Zapata,C., Srinivasan,A., Hay,B.A. and Baker,N.E.
    A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye
    Development129, 3269-3278. PubMed  Europe PubMed
  71. 2000
  72. [YEAR:1-9-2000]Hawkins,C.J., Yoo,S.J., Peterson,E.P., Wang,S.L., Vernooy,S.Y. and Hay,B.A.
    The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM
    J Biol Chem275, 27084-27093. PubMed  Europe PubMed DOI  P
  73. Kumar,S. and Doumanis,J.
    The fly caspases
    Cell Death Differ7, 1039-1044. PubMed  Europe PubMed DOI
  74. [YEAR:15-2-2000]Meier,P., Silke,J., Leevers,S.J. and Evan,G.I.
    The Drosophila caspase DRONC is regulated by DIAP1
    EMBO J19, 598-611. PubMed  Europe PubMed DOI
  75. [YEAR:22-12-2000]Quinn,L.M., Dorstyn,L., Mills,K., Colussi,P.A., Chen,P., Coombe,M., Abrams,J., Kumar,S. and Richardson,H.
    An essential role for the caspase DRONC in developmentally programmed cell death in Drosophila
    J Biol Chem275, 40416-40424. PubMed  Europe PubMed DOI
  76. 1999
  77. [YEAR:13-4-1999]Dorstyn,L., Colussi,P.A., Quinn,L.M., Richardson,H. and Kumar,S.
    DRONC, an ecdysone-inducible Drosophila caspase
    Proc Natl Acad Sci U S A96, 4307-4312. PubMed  Europe PubMed DOI