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Literature for peptidase C14.019: caspase DRONC (Drosophila melanogaster)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Suthar,K.P., Hounsell,C., Fan,Y. and Bergmann,A.
    Calcium signaling regulates apoptosis-induced proliferation in Drosophila
    PLoS Biol (2026) 24, e3003607-e3003607. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Braun,T., Afgin,N., Sapozhnikov,L., Sivan,E., Bergmann,A., Baena-Lopez,L.A., Yacobi-Sharon,K. and Arama,E.
    Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc
    Nat Commun (2025) 16, 10871-10871. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Garcia-Arias,J.M., Juarez-Uribe,R.A., Baena-Lopez,L.A., Morata,G. and Sanchez-Herrero,E.
    The homeodomain-interacting protein kinase Hipk promotes apoptosis by stabilizing the active form of Dronc
    Cell Death Discov (2025) PubMed  Europe PubMed DOI
  4. Verma,D., Sarkar,B., Singh,J., Singh,A., Mutsuddi,M. and Mukherjee,A.
    Loss of non-muscle myosin II Zipper leads to apoptosis-induced compensatory proliferation in Drosophila
    Biochim Biophys Acta Mol Cell Res (2025) 1872, 119939-119939. PubMed  Europe PubMed DOI
    5. 2024
  5. Tian,L., Li,Y. and Shi,Y.
    Dark and Dronc activation in Drosophila melanogaster
    Proc Natl Acad Sci U S A (2024) 121, e2312784121-e2312784121. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Kietz,C. and Meinander,A.
    Drosophila caspases as guardians of host-microbe interactions
    Cell Death Differ (2023) 30, 227-236. PubMed  Europe PubMed DOI  V
  7. Park,J.E., Lee,J., Ok,S., Byun,S., Chang,E.J., Yoon,S.E., Kim,Y.J. and Kang,M.J.
    Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model
    Exp Mol Med (2023) 55, 1544-1555. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2022
  8. Farrell,L., Puig-Barbe,A., Haque,M.I., Amcheslavsky,A., Yu,M., Bergmann,A. and Fan,Y.
    Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation
    PLoS Genet (2022) 18, e1010533-e1010533. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Yarikipati,P. and Bergmann,A.
    In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening
    J Vis Exp (2022) PubMed  Europe PubMed DOI
    10. 2021
  10. Lindblad,J.L., Tare,M., Amcheslavsky,A., Shields,A. and Bergmann,A.
    Non-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestine
    Sci Rep (2021) 11, 2645-2645. PubMed  Europe PubMed DOI  PMC  EPMC  K
  11. Wada,Y., Ohsawa,S. and Igaki,T.
    Yorkie ensures robust tissue growth in Drosophila ribosomal protein mutants
    Development (2021) 148 PubMed  Europe PubMed DOI
    12. 2020
  12. Amcheslavsky,A., Lindblad,J.L. and Bergmann,A.
    Transiently "Undead" Enterocytes Mediate Homeostatic Tissue Turnover in the Adult Drosophila Midgut
    Cell Rep (2020) 33, 108408-108408. PubMed  Europe PubMed DOI
  13. Arthurton,L., Nahotko,D.A., Alonso,J., Wendler,F. and Baena-Lopez,L.A.
    Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence
    EMBO Rep (2020) , e48892-e48892. PubMed  Europe PubMed DOI
  14. Chowdhury,A., Modahl,C.M., Tan,S.T., Wong Wei Xiang,B., Misse,D., Vial,T., Kini,R.M. and Pompon,J.F.
    JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands
    PLoS Pathog (2020) 16, e1008754-e1008754. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2017
  15. Jo,J., Im,S.H., Babcock,D.T., Iyer,S.C., Gunawan,F., Cox,D.N. and Galko,M.J.
    Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization
    Cell Death Dis (2017) 8, e2786-e2786. PubMed  Europe PubMed DOI
  16. Kamber Kaya,H.E., Ditzel,M., Meier,P. and Bergmann,A.
    An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways
    PLoS Genet (2017) 13, e1006438-e1006438. PubMed  Europe PubMed DOI
  17. Khan,C., Muliyil,S., Ayyub,C. and Rao,B.J.
    The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster
    J Cell Sci (2017) 130, 2984-2995. PubMed  Europe PubMed DOI
    18. 2016
  18. Lee,T.V., Kamber Kaya,H.E., Simin,R., Baehrecke,E.H. and Bergmann,A.
    The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila
    Cell Death Differ (2016) 23, 1555-1564. PubMed  Europe PubMed DOI
    19. 2015
  19. Kale,A., Li,W., Lee,C.H. and Baker,N.E.
    Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica
    Cell Death Differ (2015) 22, 1300-1312. PubMed  Europe PubMed DOI
    20. 2014
  20. Ming,M., Obata,F., Kuranaga,E. and Miura,M.
    Persephone/Spatzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila
    J Biol Chem (2014) 289, 7558-7568. PubMed  Europe PubMed DOI  K
    21. 2013
  21. Huang,N., Civciristov,S., Hawkins,C.J. and Clem,R.J.
    SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda
    Insect Biochem Mol Biol (2013) 43, 444-454. PubMed  Europe PubMed DOI
  22. Kitaguchi,K., Hamajima,R., Yamada,H., Kobayashi,M. and Ikeda,M.
    Transient expression assay reveals kinetic difference in the proteolytic processing between Dronc proteins from the gypsy moth Lymantria dispar and the silkworm Bombyx mori
    J Insect Biotechnol Sericology (2013) 82, 49-54. DOI
  23. Yamada,H., Kitaguchi,K., Hamajima,R., Kobayashi,M. and Ikeda,M.
    Novel apoptosis suppressor Apsup from the baculovirus Lymantria dispar multiple nucleopolyhedrovirus precludes apoptosis by preventing proteolytic processing of initiator caspase Dronc
    J Virol (2013) 87, 12925-12934. PubMed  Europe PubMed DOI
  24. Zhang,J.Y., Xu,W., Pan,C., Yi,H.S., Hu,Y.F., Song,J., Pan,M.H. and Lu,C.
    Cloning and characterization of the caspase family member bmdronc from Bombyx mori (Lepidoptera: Bombycidae) embryo cells
    Ann Entomol Soc Am (2013) 106, 265-272. DOI
    25. 2012
  25. Dorstyn,L. and Kumar,S.
    Insect caspases
    [ISSN:978-0-12-407743-0] (2012) 3, 2286-2295. DOI
  26. Verghese,S., Bedi,S. and Kango-Singh,M.
    Hippo signalling controls Dronc activity to regulate organ size in Drosophila
    Cell Death Differ (2012) 19, 1664-1676. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2011
  27. Khammari,A., Agnes,F., Gandille,P. and Pret,A.M.
    Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1
    Cell Death Differ (2011) 18, 793-805. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Lee,G., Wang,Z., Sehgal,R., Chen,C.H., Kikuno,K., Hay,B. and Park,J.H.
    Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis
    J Comp Neurol (2011) 519, 34-48. PubMed  Europe PubMed DOI
  29. Lee,T.V., Fan,Y., Wang,S., Srivastava,M., Broemer,M., Meier,P. and Bergmann,A.
    Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation
    PLoS Genet (2011) 7, e1002261-e1002261. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Ouyang,Y., Petritsch,C., Wen,H., Jan,L., Jan,Y.N. and Lu,B.
    Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila
    Development (2011) 138, 2185-2196. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Suganuma,I., Ushiyama,T., Yamada,H., Iwamoto,A., Kobayashi,M. and Ikeda,M.
    Cloning and characterization of a dronc homologue in the silkworm, Bombyx mori
    Insect Biochem Mol Biol (2011) 41, 909-921. PubMed  Europe PubMed DOI
    32. 2010
  32. Fan,Y. and Bergmann,A.
    The cleaved-caspase-3 antibody is a marker of caspase-9-like DRONC activity in Drosophila
    Cell Death Differ (2010) 17, 534-539. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Yang,C.S., Thomenius,M.J., Gan,E.C., Tang,W., Freel,C.D., Merritt,T.J., Nutt,L.K. and Kornbluth,S.
    Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc
    EMBO J (2010) 29, 3196-3207. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2008
  34. Dorstyn,L. and Kumar,S.
    A biochemical analysis of the activation of the Drosophila caspase DRONC
    Cell Death Differ (2008) 15, 461-470. PubMed  Europe PubMed DOI
  35. Snipas,S.J., Drag,M., Stennicke,H.R. and Salvesen,G.S.
    Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC
    Cell Death Differ (2008) 15, 938-945. PubMed  Europe PubMed DOI  P
    36. 2007
  36. Baum,J.S., Arama,E., Steller,H. and McCall,K.
    The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis
    Cell Death Differ (2007) 14, 1508-1517. PubMed  Europe PubMed DOI
  37. Cooper,D.M., Thi,E.P., Chamberlain,C.M., Pio,F. and Lowenberger,C.
    Aedes Dronc: a novel ecdysone-inducible caspase in the yellow fever mosquito, Aedes aegypti
    Insect Mol Biol (2007) 16, 563-572. PubMed  Europe PubMed DOI
    38. 2006
  38. Kondo,S., Senoo-Matsuda,N., Hiromi,Y. and Miura,M.
    DRONC coordinates cell death and compensatory proliferation
    Mol Cell Biol (2006) 26, 7258-7268. PubMed  Europe PubMed DOI  PMC  EPMC
  39. [YEAR:30-1-2006]Yan,N., Huh,J.R., Schirf,V., Demeler,B., Hay,B.A. and Shi,Y.
    Structure and activation mechanism of the Drosophila initiator caspase Dronc
    J Biol Chem (30-1-2006) 281, 8667-8674. PubMed  Europe PubMed DOI  S
    40. 2005
  40. Mills,K., Daish,T. and Kumar,S.
    The function of the Drosophila caspase DRONC in cell death and development
    Cell Cycle (2005) 4, 744-746. PubMed  Europe PubMed
  41. [YEAR:17-3-2005]Muro,I., Means,J.C. and Clem,R.J.
    Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells
    J Biol Chem (17-3-2005) 280, 18683-18688. PubMed  Europe PubMed DOI
  42. [YEAR:25-5-2005]Waldhuber,M., Emoto,K. and Petritsch,C.
    The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals
    Mech Dev (25-5-2005) 122, 914-927. PubMed  Europe PubMed DOI
  43. Xu,D., Li,Y., Arcaro,M., Lackey,M. and Bergmann,A.
    The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
    Development (2005) 132, 2125-2134. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2004
  44. Chew,S.K., Akdemir,F., Chen,P., Lu,W.J., Mills,K., Daish,T., Kumar,S., Rodriguez,A. and Abrams,J.M.
    The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila
    Dev Cell (2004) 7, 897-907. PubMed  Europe PubMed DOI  K
  45. Daish,T.J., Mills,K. and Kumar,S.
    Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis
    Dev Cell (2004) 7, 909-915. PubMed  Europe PubMed DOI  K
  46. [YEAR:27-7-2004]Huh,J.R., Guo,M. and Hay,B.A.
    Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase dronc in a nonapoptotic role
    Curr Biol (27-7-2004) 14, 1262-1266. PubMed  Europe PubMed DOI
  47. Kumar,S.
    Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical "apoptotic caspase"
    Sci STKE (2004) 2004, e49-e49. PubMed  Europe PubMed DOI
  48. Muro,I., Monser,K. and Clem,R.J.
    Mechanism of Dronc activation in Drosophila cells
    J Cell Sci (2004) 117, 5035-5041. PubMed  Europe PubMed DOI
    49. 2003
  49. Chai,J., Yan,N., Huh,J.R., Wu,J.W., Li,W., Hay,B.A. and Shi,Y.
    Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
    Nat Struct Biol (2003) 10, 892-898. PubMed  Europe PubMed DOI
  50. [YEAR:29-8-2003]Daish,T.J., Cakouros,D. and Kumar,S.
    Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc
    Cell Death Differ (29-8-2003) 10, 1348-1356. PubMed  Europe PubMed DOI
    51. 2002
  51. [YEAR:10-6-2002]Cakouros,D., Daish,T., Martin,D., Baehrecke,E.H. and Kumar,S.
    Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex
    J Cell Biol (10-6-2002) 157, 985-995. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Igaki,T., Yamamoto-Goto,Y., Tokushige,N., Kanda,H. and Miura,M.
    Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC
    J Biol Chem (2002) 277, 23103-23106. PubMed  Europe PubMed DOI
  53. [YEAR:20-12-2002]Muro,I., Hay,B.A. and Clem,R.J.
    The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
    J Biol Chem (20-12-2002) 277, 49644-49650. PubMed  Europe PubMed DOI  I
  54. Wilson,R., Goyal,L., Ditzel,M., Zachariou,A., Baker,D.A., Agapite,J., Steller,H. and Meier,P.
    The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
    Nat Cell Biol (2002) 4, 445-450. PubMed  Europe PubMed DOI
  55. Yu,S.Y., Yoo,S.J., Yang,L., Zapata,C., Srinivasan,A., Hay,B.A. and Baker,N.E.
    A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye
    Development (2002) 129, 3269-3278. PubMed  Europe PubMed
    56. 2000
  56. [YEAR:1-9-2000]Hawkins,C.J., Yoo,S.J., Peterson,E.P., Wang,S.L., Vernooy,S.Y. and Hay,B.A.
    The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM
    J Biol Chem (1-9-2000) 275, 27084-27093. PubMed  Europe PubMed DOI  P
  57. Kumar,S. and Doumanis,J.
    The fly caspases
    Cell Death Differ (2000) 7, 1039-1044. PubMed  Europe PubMed DOI
  58. [YEAR:15-2-2000]Meier,P., Silke,J., Leevers,S.J. and Evan,G.I.
    The Drosophila caspase DRONC is regulated by DIAP1
    EMBO J (15-2-2000) 19, 598-611. PubMed  Europe PubMed DOI  PMC  EPMC
  59. [YEAR:22-12-2000]Quinn,L.M., Dorstyn,L., Mills,K., Colussi,P.A., Chen,P., Coombe,M., Abrams,J., Kumar,S. and Richardson,H.
    An essential role for the caspase DRONC in developmentally programmed cell death in Drosophila
    J Biol Chem (22-12-2000) 275, 40416-40424. PubMed  Europe PubMed DOI
    60. 1999
  60. [YEAR:13-4-1999]Dorstyn,L., Colussi,P.A., Quinn,L.M., Richardson,H. and Kumar,S.
    DRONC, an ecdysone-inducible Drosophila caspase
    Proc Natl Acad Sci U S A (13-4-1999) 96, 4307-4312. PubMed  Europe PubMed DOI  PMC  EPMC

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