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Literature for peptidase C14.019: caspase DRONC (Drosophila melanogaster)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Suthar,K.P., Hounsell,C., Fan,Y. and Bergmann,A.<br>Calcium signaling regulates apoptosis-induced proliferation in Drosophila<br>PLoS Biol (2026) 24, e3003607-e3003607. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Braun,T., Afgin,N., Sapozhnikov,L., Sivan,E., Bergmann,A., Baena-Lopez,L.A., Yacobi-Sharon,K. and Arama,E.<br>Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc<br>Nat Commun (2025) 16, 10871-10871. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Garcia-Arias,J.M., Juarez-Uribe,R.A., Baena-Lopez,L.A., Morata,G. and Sanchez-Herrero,E.<br>The homeodomain-interacting protein kinase Hipk promotes apoptosis by stabilizing the active form of Dronc<br>Cell Death Discov (2025) PubMed  Europe PubMed DOI
  4. Verma,D., Sarkar,B., Singh,J., Singh,A., Mutsuddi,M. and Mukherjee,A.<br>Loss of non-muscle myosin II Zipper leads to apoptosis-induced compensatory proliferation in Drosophila<br>Biochim Biophys Acta Mol Cell Res (2025) 1872, 119939-119939. PubMed  Europe PubMed DOI
    5. 2024
  5. Tian,L., Li,Y. and Shi,Y.<br>Dark and Dronc activation in Drosophila melanogaster<br>Proc Natl Acad Sci U S A (2024) 121, e2312784121-e2312784121. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Kietz,C. and Meinander,A.<br>Drosophila caspases as guardians of host-microbe interactions<br>Cell Death Differ (2023) 30, 227-236. PubMed  Europe PubMed DOI  V
  7. Park,J.E., Lee,J., Ok,S., Byun,S., Chang,E.J., Yoon,S.E., Kim,Y.J. and Kang,M.J.<br>Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model<br>Exp Mol Med (2023) 55, 1544-1555. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2022
  8. Farrell,L., Puig-Barbe,A., Haque,M.I., Amcheslavsky,A., Yu,M., Bergmann,A. and Fan,Y.<br>Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation<br>PLoS Genet (2022) 18, e1010533-e1010533. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Yarikipati,P. and Bergmann,A.<br>In Vitro Cleavage Assays using Purified Recombinant Drosophila Caspases for Substrate Screening<br>J Vis Exp (2022) PubMed  Europe PubMed DOI
    10. 2021
  10. Lindblad,J.L., Tare,M., Amcheslavsky,A., Shields,A. and Bergmann,A.<br>Non-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestine<br>Sci Rep (2021) 11, 2645-2645. PubMed  Europe PubMed DOI  PMC  EPMC  K
  11. Wada,Y., Ohsawa,S. and Igaki,T.<br>Yorkie ensures robust tissue growth in Drosophila ribosomal protein mutants<br>Development (2021) 148 PubMed  Europe PubMed DOI
    12. 2020
  12. Amcheslavsky,A., Lindblad,J.L. and Bergmann,A.<br>Transiently "Undead" Enterocytes Mediate Homeostatic Tissue Turnover in the Adult Drosophila Midgut<br>Cell Rep (2020) 33, 108408-108408. PubMed  Europe PubMed DOI
  13. Arthurton,L., Nahotko,D.A., Alonso,J., Wendler,F. and Baena-Lopez,L.A.<br>Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence<br>EMBO Rep (2020) , e48892-e48892. PubMed  Europe PubMed DOI
  14. Chowdhury,A., Modahl,C.M., Tan,S.T., Wong Wei Xiang,B., Misse,D., Vial,T., Kini,R.M. and Pompon,J.F.<br>JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands<br>PLoS Pathog (2020) 16, e1008754-e1008754. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2017
  15. Jo,J., Im,S.H., Babcock,D.T., Iyer,S.C., Gunawan,F., Cox,D.N. and Galko,M.J.<br>Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization<br>Cell Death Dis (2017) 8, e2786-e2786. PubMed  Europe PubMed DOI
  16. Kamber Kaya,H.E., Ditzel,M., Meier,P. and Bergmann,A.<br>An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways<br>PLoS Genet (2017) 13, e1006438-e1006438. PubMed  Europe PubMed DOI
  17. Khan,C., Muliyil,S., Ayyub,C. and Rao,B.J.<br>The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster<br>J Cell Sci (2017) 130, 2984-2995. PubMed  Europe PubMed DOI
    18. 2016
  18. Lee,T.V., Kamber Kaya,H.E., Simin,R., Baehrecke,E.H. and Bergmann,A.<br>The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila<br>Cell Death Differ (2016) 23, 1555-1564. PubMed  Europe PubMed DOI
    19. 2015
  19. Kale,A., Li,W., Lee,C.H. and Baker,N.E.<br>Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica<br>Cell Death Differ (2015) 22, 1300-1312. PubMed  Europe PubMed DOI
    20. 2014
  20. Ming,M., Obata,F., Kuranaga,E. and Miura,M.<br>Persephone/Spatzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila<br>J Biol Chem (2014) 289, 7558-7568. PubMed  Europe PubMed DOI  K
    21. 2013
  21. Huang,N., Civciristov,S., Hawkins,C.J. and Clem,R.J.<br>SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda<br>Insect Biochem Mol Biol (2013) 43, 444-454. PubMed  Europe PubMed DOI
  22. Kitaguchi,K., Hamajima,R., Yamada,H., Kobayashi,M. and Ikeda,M.<br>Transient expression assay reveals kinetic difference in the proteolytic processing between Dronc proteins from the gypsy moth Lymantria dispar and the silkworm Bombyx mori<br>J Insect Biotechnol Sericology (2013) 82, 49-54. DOI
  23. Yamada,H., Kitaguchi,K., Hamajima,R., Kobayashi,M. and Ikeda,M.<br>Novel apoptosis suppressor Apsup from the baculovirus Lymantria dispar multiple nucleopolyhedrovirus precludes apoptosis by preventing proteolytic processing of initiator caspase Dronc<br>J Virol (2013) 87, 12925-12934. PubMed  Europe PubMed DOI
  24. Zhang,J.Y., Xu,W., Pan,C., Yi,H.S., Hu,Y.F., Song,J., Pan,M.H. and Lu,C.<br>Cloning and characterization of the caspase family member bmdronc from Bombyx mori (Lepidoptera: Bombycidae) embryo cells<br>Ann Entomol Soc Am (2013) 106, 265-272. DOI
    25. 2012
  25. Dorstyn,L. and Kumar,S.<br>Insect caspases<br>[ISSN:978-0-12-407743-0] (2012) 3, 2286-2295. DOI
  26. Verghese,S., Bedi,S. and Kango-Singh,M.<br>Hippo signalling controls Dronc activity to regulate organ size in Drosophila<br>Cell Death Differ (2012) 19, 1664-1676. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2011
  27. Khammari,A., Agnes,F., Gandille,P. and Pret,A.M.<br>Physiological apoptosis of polar cells during Drosophila oogenesis is mediated by Hid-dependent regulation of Diap1<br>Cell Death Differ (2011) 18, 793-805. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Lee,G., Wang,Z., Sehgal,R., Chen,C.H., Kikuno,K., Hay,B. and Park,J.H.<br>Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis<br>J Comp Neurol (2011) 519, 34-48. PubMed  Europe PubMed DOI
  29. Lee,T.V., Fan,Y., Wang,S., Srivastava,M., Broemer,M., Meier,P. and Bergmann,A.<br>Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation<br>PLoS Genet (2011) 7, e1002261-e1002261. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Ouyang,Y., Petritsch,C., Wen,H., Jan,L., Jan,Y.N. and Lu,B.<br>Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila<br>Development (2011) 138, 2185-2196. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Suganuma,I., Ushiyama,T., Yamada,H., Iwamoto,A., Kobayashi,M. and Ikeda,M.<br>Cloning and characterization of a dronc homologue in the silkworm, Bombyx mori<br>Insect Biochem Mol Biol (2011) 41, 909-921. PubMed  Europe PubMed DOI
    32. 2010
  32. Fan,Y. and Bergmann,A.<br>The cleaved-caspase-3 antibody is a marker of caspase-9-like DRONC activity in Drosophila<br>Cell Death Differ (2010) 17, 534-539. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Yang,C.S., Thomenius,M.J., Gan,E.C., Tang,W., Freel,C.D., Merritt,T.J., Nutt,L.K. and Kornbluth,S.<br>Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc<br>EMBO J (2010) 29, 3196-3207. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2008
  34. Dorstyn,L. and Kumar,S.<br>A biochemical analysis of the activation of the Drosophila caspase DRONC<br>Cell Death Differ (2008) 15, 461-470. PubMed  Europe PubMed DOI
  35. Snipas,S.J., Drag,M., Stennicke,H.R. and Salvesen,G.S.<br>Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC<br>Cell Death Differ (2008) 15, 938-945. PubMed  Europe PubMed DOI  P
    36. 2007
  36. Baum,J.S., Arama,E., Steller,H. and McCall,K.<br>The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis<br>Cell Death Differ (2007) 14, 1508-1517. PubMed  Europe PubMed DOI
  37. Cooper,D.M., Thi,E.P., Chamberlain,C.M., Pio,F. and Lowenberger,C.<br>Aedes Dronc: a novel ecdysone-inducible caspase in the yellow fever mosquito, Aedes aegypti<br>Insect Mol Biol (2007) 16, 563-572. PubMed  Europe PubMed DOI
    38. 2006
  38. Kondo,S., Senoo-Matsuda,N., Hiromi,Y. and Miura,M.<br>DRONC coordinates cell death and compensatory proliferation<br>Mol Cell Biol (2006) 26, 7258-7268. PubMed  Europe PubMed DOI  PMC  EPMC
  39. [YEAR:30-1-2006]Yan,N., Huh,J.R., Schirf,V., Demeler,B., Hay,B.A. and Shi,Y.<br>Structure and activation mechanism of the Drosophila initiator caspase Dronc<br>J Biol Chem (30-1-2006) 281, 8667-8674. PubMed  Europe PubMed DOI  S
    40. 2005
  40. Mills,K., Daish,T. and Kumar,S.<br>The function of the Drosophila caspase DRONC in cell death and development<br>Cell Cycle (2005) 4, 744-746. PubMed  Europe PubMed
  41. [YEAR:17-3-2005]Muro,I., Means,J.C. and Clem,R.J.<br>Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells<br>J Biol Chem (17-3-2005) 280, 18683-18688. PubMed  Europe PubMed DOI
  42. [YEAR:25-5-2005]Waldhuber,M., Emoto,K. and Petritsch,C.<br>The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals<br>Mech Dev (25-5-2005) 122, 914-927. PubMed  Europe PubMed DOI
  43. Xu,D., Li,Y., Arcaro,M., Lackey,M. and Bergmann,A.<br>The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila<br>Development (2005) 132, 2125-2134. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2004
  44. Chew,S.K., Akdemir,F., Chen,P., Lu,W.J., Mills,K., Daish,T., Kumar,S., Rodriguez,A. and Abrams,J.M.<br>The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila<br>Dev Cell (2004) 7, 897-907. PubMed  Europe PubMed DOI  K
  45. Daish,T.J., Mills,K. and Kumar,S.<br>Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis<br>Dev Cell (2004) 7, 909-915. PubMed  Europe PubMed DOI  K
  46. [YEAR:27-7-2004]Huh,J.R., Guo,M. and Hay,B.A.<br>Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase dronc in a nonapoptotic role<br>Curr Biol (27-7-2004) 14, 1262-1266. PubMed  Europe PubMed DOI
  47. Kumar,S.<br>Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical "apoptotic caspase"<br>Sci STKE (2004) 2004, e49-e49. PubMed  Europe PubMed DOI
  48. Muro,I., Monser,K. and Clem,R.J.<br>Mechanism of Dronc activation in Drosophila cells<br>J Cell Sci (2004) 117, 5035-5041. PubMed  Europe PubMed DOI
    49. 2003
  49. Chai,J., Yan,N., Huh,J.R., Wu,J.W., Li,W., Hay,B.A. and Shi,Y.<br>Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination<br>Nat Struct Biol (2003) 10, 892-898. PubMed  Europe PubMed DOI
  50. [YEAR:29-8-2003]Daish,T.J., Cakouros,D. and Kumar,S.<br>Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc<br>Cell Death Differ (29-8-2003) 10, 1348-1356. PubMed  Europe PubMed DOI
    51. 2002
  51. [YEAR:10-6-2002]Cakouros,D., Daish,T., Martin,D., Baehrecke,E.H. and Kumar,S.<br>Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex<br>J Cell Biol (10-6-2002) 157, 985-995. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Igaki,T., Yamamoto-Goto,Y., Tokushige,N., Kanda,H. and Miura,M.<br>Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC<br>J Biol Chem (2002) 277, 23103-23106. PubMed  Europe PubMed DOI
  53. [YEAR:20-12-2002]Muro,I., Hay,B.A. and Clem,R.J.<br>The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC<br>J Biol Chem (20-12-2002) 277, 49644-49650. PubMed  Europe PubMed DOI  I
  54. Wilson,R., Goyal,L., Ditzel,M., Zachariou,A., Baker,D.A., Agapite,J., Steller,H. and Meier,P.<br>The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis<br>Nat Cell Biol (2002) 4, 445-450. PubMed  Europe PubMed DOI
  55. Yu,S.Y., Yoo,S.J., Yang,L., Zapata,C., Srinivasan,A., Hay,B.A. and Baker,N.E.<br>A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye<br>Development (2002) 129, 3269-3278. PubMed  Europe PubMed
    56. 2000
  56. [YEAR:1-9-2000]Hawkins,C.J., Yoo,S.J., Peterson,E.P., Wang,S.L., Vernooy,S.Y. and Hay,B.A.<br>The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM<br>J Biol Chem (1-9-2000) 275, 27084-27093. PubMed  Europe PubMed DOI  P
  57. Kumar,S. and Doumanis,J.<br>The fly caspases<br>Cell Death Differ (2000) 7, 1039-1044. PubMed  Europe PubMed DOI
  58. [YEAR:15-2-2000]Meier,P., Silke,J., Leevers,S.J. and Evan,G.I.<br>The Drosophila caspase DRONC is regulated by DIAP1<br>EMBO J (15-2-2000) 19, 598-611. PubMed  Europe PubMed DOI  PMC  EPMC
  59. [YEAR:22-12-2000]Quinn,L.M., Dorstyn,L., Mills,K., Colussi,P.A., Chen,P., Coombe,M., Abrams,J., Kumar,S. and Richardson,H.<br>An essential role for the caspase DRONC in developmentally programmed cell death in Drosophila<br>J Biol Chem (22-12-2000) 275, 40416-40424. PubMed  Europe PubMed DOI
    60. 1999
  60. [YEAR:13-4-1999]Dorstyn,L., Colussi,P.A., Quinn,L.M., Richardson,H. and Kumar,S.<br>DRONC, an ecdysone-inducible Drosophila caspase<br>Proc Natl Acad Sci U S A (13-4-1999) 96, 4307-4312. PubMed  Europe PubMed DOI  PMC  EPMC

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