Literature for peptidase C14.003: caspase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Qing,Y., Xu,S., Yang,D., Liu,J. and Cao,H. Thalidezine triggers Cathepsin B-mediated cell death in T-cell lymphoma by disrupting lysosomal function Chem Biol Interact (2026) 427, 111932-111932. PubMed Europe PubMed DOI K
Shi,J., Kim,Y.E., DeRuiter,N.J., Kadav,P. and Tessier-Lavigne,M. Caspase-3 cleaves and activates the NADase SARM1 to promote apoptosis, linking two cell death mechanisms Proc Natl Acad Sci U S A (2026) 123, e2528118123-e2528118123. PubMed Europe PubMed DOI PMC EPMC

2025

Andoh,M., Shinoda,N., Taira,Y., Araki,T., Kasahara,Y., Takeuchi,H., Miura,M., Ikegaya,Y. and Koyama,R. Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia Nat Commun (2025) 16, 918-918. PubMed Europe PubMed DOI PMC EPMC
Charli,A., Chang,Y.T., Luo,J., Palanisamy,B., Malovic,E., Riaz,Z., Miller,C., Samidurai,M., Zenitsky,G., Jin,H., Anantharam,V., Kanthasamy,A. and Kanthasamy,A.G. Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCdelta and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases Front Cell Neurosci (2025) 19, 1549265-1549265. PubMed Europe PubMed DOI PMC EPMC K
Ma,J., Zhao,J., Zhang,C., Tan,J., Cheng,A., Niu,Z., Lin,Z., Pan,G., Chen,C., Ding,Y., Zhong,M., Zhuang,Y., Xiong,Y., Zhou,H., Zhou,S., Xu,M., Ye,W., Li,F., Song,Y., Wang,Z. and Hong,X. Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy Nat Commun (2025) 16, 5006-5006. PubMed Europe PubMed DOI PMC EPMC
Shen,J., Zhang,Y., Tang,W., Yang,M., Cheng,T., Chen,Y., Yu,S., Guo,Q., Cao,L., Wang,X., Xiao,H., Wang,L., Wang,C., Liu,C.Y. and Meng,G. Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth Nat Immunol (2025) PubMed Europe PubMed DOI
Vidak,E., Vizovisek,M., Kavcic,N., Biasizzo,M., Fonovic,M. and Turk,B. Apoptotic Caspases-3 and -7 Cleave Extracellular Domains of Membrane-Bound Proteins from MDA-MB-231 Breast Cancer Cells Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC
Wang,X., Xie,X., Ni,J.Y., Li,J.Y., Sun,X.A., Xie,H.Y., Yang,N.H., Guo,H.J., Lu,L., Ning,M., Zhou,L., Liu,J., Xu,C., Zhang,W., Wen,Y., Shen,Q., Xu,H. and Lu,L.M. USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation Acta Pharmacol Sin (2025) 46, 159-170. PubMed Europe PubMed DOI
Wu,D., Zhang,S., Wu,Y., Bi,X., Zhou,Y. and Wu,W. Sulforaphane downregulates mitochondrial TIGAR via inhibiting mitochondrial transmembrane assembly and LONP1/CASP3 axis causing apoptosis Biochem Biophys Res Commun (2025) 760, 151689-151689. PubMed Europe PubMed DOI K
Zhang,Z., Lin,X., Yang,Y., Wang,X., Wang,Y., Huang,X., Hong,M., Gao,W., He,H., You,M.J., Yang,Y. and Kong,G. Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML Cancer Biol Ther (2025) 26, 2459426-2459426. PubMed Europe PubMed DOI PMC EPMC K
Zhong,Z., Mao,X., Zhang,J., Bu,W., Guan,Z., Wang,Y., Xiao,S., Deng,Y. and Jiang,J. ER-localized ERO1alpha and caspase-3-mediated cleavage of mitochondrial NDUFS1 drives trichothecene-induced ROS accumulation in liver Free Radic Biol Med (2025) 244, 452-463. PubMed Europe PubMed DOI

2024

Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X. The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death Mol Cell (2024) 84, 170-179. PubMed Europe PubMed DOI V
Bertani,F.R., Moghaddam,F.D., Panella,C., Giannitelli,S.M., Peluzzi,V., Gerardino,A., Rainer,A., Roscilli,G., De Ninno,A. and Businaro,L. Kinetic Detection of Apoptosis Events Via Caspase 3/7 Activation in a Tumor-Immune Microenvironment on a Chip Methods Mol Biol (2024) 2748, 109-118. PubMed Europe PubMed DOI
Berthenet,K., Aimontche,E., El Mrini,S., Briere,J., Pion,N., Iacono,I., Brejon,S., Monier,K., Catez,F., Ichim,G., Combaret,V., Mertani,H.C., Diaz,J.J. and Albaret,M.A. Spatial sequestration of activated-caspase 3 in aggresomes mediates resistance of neuroblastoma cell to bortezomib treatment Sci Rep (2024) 14, 3768-3768. PubMed Europe PubMed DOI PMC EPMC I
Collins,J., Piscopio,R.A., Reyland,M.E., Johansen,C.G., Benninger,R.K.P. and Farnsworth,N.L. Cleavage of protein kinase c delta by caspase-3 mediates pro-inflammatory cytokine-induced apoptosis in pancreatic islets J Biol Chem (2024) , 107611-107611. PubMed Europe PubMed DOI
Fernandes,J.P., Branton,W.G., Cohen,E.A., Koopman,G., Kondova,I., Gelman,B.B. and Power,C. Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder Brain (2024) 147, 717-734. PubMed Europe PubMed DOI PMC EPMC K
Ge,J., Wang,Y., Li,X., Lu,Q., Yu,H., Liu,H., Ma,K., Deng,X., Luo,Z.Q., Liu,X. and Qiu,J. Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death Nat Commun (2024) 15, 8464-8464. PubMed Europe PubMed DOI PMC EPMC
Li,S., Song,J., Liu,J., Zhou,S., Zhao,G., Li,T., Huang,L., Li,J. and Weng,C. African swine fever virus infection regulates pyroptosis by cleaving gasdermin A (GSDMA) via active caspase-3 and caspase-4 J Biol Chem (2024) , 107307-107307. PubMed Europe PubMed DOI
Pandit,S., Duchow,M., Chao,W., Capasso,A. and Samanta,D. DNA-Barcoded Plasmonic Nanostructures for Activity-Based Protease Sensing Angew Chem Int Ed Engl (2024) 63, e202310964-e202310964. PubMed Europe PubMed DOI
Vesela,B., Sevcikova,A., Holomkova,K., Ramesova,A., Kratochvilova,A., Sharpe,P.T. and Matalova,E. Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells Pflugers Arch (2024) PubMed Europe PubMed DOI
Wright,S.S., Wang,C., Ta,A., Havira,M.S., Ruan,J., Rathinam,V.A. and Vanaja,S.K. A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis Cell Rep (2024) 43, 114004-114004. PubMed Europe PubMed DOI
Xu,H., Yuan,Z., Qin,K., Jiang,S. and Sun,L. The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation elife (2024) 12 PubMed Europe PubMed DOI PMC EPMC
Yang,J., Li,Y., Li,H., Zhang,H., Guo,H., Zheng,X., Yu,X.F. and Wei,W. HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43 EMBO Rep (2024) 25, 4337-4357. PubMed Europe PubMed DOI
Zhuang,Y., Dong,H., Liu,T., Zhao,Y., Xu,Y., Zhao,X. and Sun,D. Highly sensitive and selective SERS detection of caspase-3 during cell apoptosis based on the target-induced hotspot effect Analyst (2024) 149, 490-496. PubMed Europe PubMed DOI

2023

Brunette,S., Sharma,A., Bell,R., Puente,L. and Megeney,L.A. Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates Microb Cell (2023) 10, 157-169. PubMed Europe PubMed DOI PMC EPMC
Chakraborty,S., Choudhuri,A., Mishra,A., Bhattacharyya,C., Billiar,T.R., Stoyanovsky,D.A. and Sengupta,R. Nitric oxide and thioredoxin modulate the activity of caspase 9 in HepG2 cells Biochim Biophys Acta Gen Subj (2023) 1867, 130452-130452. PubMed Europe PubMed DOI PMC EPMC
Dou,H., Yu,P.Y., Liu,Y.Q., Zhu,Y., Li,F.C., Wang,Y.Y., Chen,X.Y. and Xiao,M. Recent advances in caspase-3, breast cancer, and traditional Chinese medicine: a review J Chemother (2023) , 1-19. PubMed Europe PubMed DOI
Duarte-Olivenza,C., Moran,G., Hurle,J.M., Lorda-Diez,C.I. and Montero,J.A. Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death Cell Death Dis (2023) 14, 813-813. PubMed Europe PubMed DOI PMC EPMC
Grabert,K., Engskog-Vlachos,P., Skandik,M., Vazquez-Cabrera,G., Murgoci,A.N., Keane,L., Gaetani,M., Joseph,B. and Cheray,M. Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate Cell Death Dis (2023) 14, 192-192. PubMed Europe PubMed DOI PMC EPMC
Jiao,C., Zhang,H., Li,H., Fu,X., Lin,Y., Cao,C., Liu,S., Liu,Y. and Li,P. Caspase-3/GSDME mediated pyroptosis: A potential pathway for sepsis Int Immunopharmacol (2023) 124, 111022-111022. PubMed Europe PubMed DOI V
Li,C., Pang,Y., Wang,Y., Zhou,Y., Fang,L., Xiao,S. and Qiu,D. Cloning, expression of porcine GSDME and identification of its site cleaved by caspase-3 Biochem Biophys Res Commun (2023) 669, 61-67. PubMed Europe PubMed DOI
Zhang,X., Shan,P., Otterbein,L.E., Alam,J., Flavell,R.A., Davis,R.J., Choi,A.M.K. and Lee,P.J. Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3 J Biol Chem (2023) 299, 105304-105304. PubMed Europe PubMed DOI PMC EPMC

2022

Bresinsky,M., Strasser,J.M., Vallaster,B., Liu,P., McCue,W.M., Fuller,J., Hubmann,A., Singh,G., Nelson,K.M., Cuellar,M.E., Wilmot,C.M., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S. Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314 ACS Pharmacol Transl Sci (2022) 5, 20-40. PubMed Europe PubMed DOI PMC EPMC I
De Silva,E., Devine,D.V., Jan,E., Roskelley,C.D. and Kim,H. Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner Biochem J (2022) 479, 2351-2364. PubMed Europe PubMed DOI
Eskandari,E. and Eaves,C.J. Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis J Cell Biol (2022) 221 PubMed Europe PubMed DOI PMC EPMC V
Ghazavi,F., Huysentruyt,J., De Coninck,J., Kourula,S., Martens,S., Hassannia,B., Wartewig,T., Divert,T., Roelandt,R., Popper,B., Hiergeist,A., Tougaard,P., Vanden Berghe,T., Joossens,M., Berx,G., Takahashi,N., Wahida,A. and Vandenabeele,P. Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state Proc Natl Acad Sci U S A (2022) 119 PubMed Europe PubMed DOI PMC EPMC
Hung,M.C., Wang,W.P. and Chi,Y.H. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer Cell Biosci (2022) 12, 122-122. PubMed Europe PubMed DOI PMC EPMC
Rahimi,A., Karimipoor,M., Mahdian,R., Alipour,A., Hosseini,S., Kaghazian,H., Abbasi,A., Shahsavarani,H. and Shokrgozar,M.A. Targeting Caspase-3 Gene in rCHO Cell Line by CRISPR/Cas9 Editing Tool and Its Effect on Protein Production in Manipulated Cell Line Iran J Pharm Res (2022) 21, e130236-e130236. PubMed Europe PubMed DOI PMC EPMC
Roychowdhury,H. and Romero,P.A. Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation Cell Death Discov (2022) 8, 7-7. PubMed Europe PubMed DOI PMC EPMC
Silva,F.F.V.E., Padin-Iruegas,M.E., Caponio,V.C.A., Lorenzo-Pouso,A.I., Saavedra-Nieves,P., Chamorro-Petronacci,C.M., Suarez-Penaranda,J. and Perez-Sayans,M. Caspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC V
Weir,A. and Vince,J.E. No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death Biochem J (2022) 479, 1083-1102. PubMed Europe PubMed DOI PMC EPMC V
Ye,X., Li,Y., Lv,B., Qiu,B., Zhang,S., Peng,H., Kong,W., Tang,C., Huang,Y., Du,J. and Jin,H. Endogenous Hydrogen Sulfide Persulfidates Caspase-3 at Cysteine 163 to Inhibit Doxorubicin-Induced Cardiomyocyte Apoptosis Oxid Med Cell Longev (2022) 2022, 6153772-6153772. PubMed Europe PubMed DOI PMC EPMC
Zichittella,C., Barreca,M.M., Cordaro,A., Corrado,C., Alessandro,R. and Conigliaro,A. Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells BMC Cancer (2022) 22, 567-567. PubMed Europe PubMed DOI PMC EPMC

2021

Anson,F., Kanjilal,P., Thayumanavan,S. and Hardy,J.A. Tracking exogenous intracellular casp-3 using split GFP Protein Sci (2021) 30, 366-380. PubMed Europe PubMed DOI
Asadi,M., Taghizadeh,S., Kaviani,E., Vakili,O., Taheri-Anganeh,M., Tahamtan,M. and Savardashtaki,A. Caspase-3: Structure, function, and biotechnological aspects Biotechnol Appl Biochem (2021) PubMed Europe PubMed DOI V
Awazu,M., Yamaguchi,Y., Nagata,M., Miura,M. and Hida,M. Caspase-3 regulates ureteric branching in mice via cell migration Biochem Biophys Res Commun (2021) 559, 28-34. PubMed Europe PubMed DOI
Beroske,L., Van den Wyngaert,T., Stroobants,S., Van der Veken,P. and Elvas,F. Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Burgener,S.S., Brugger,M., Leborgne,N.G.F., Sollberger,S., Basilico,P., Kaufmann,T., Bird,P.I. and Benarafa,C. Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells Front Cell Dev Biol (2021) 9, 630166-630166. PubMed Europe PubMed DOI PMC EPMC
Du,Y., Taylor,C.G., Aukema,H.M. and Zahradka,P. Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases Biochim Biophys Acta Mol Cell Biol Lipids (2021) 1866, 158902-158902. PubMed Europe PubMed DOI
Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M. Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2 Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Kim,J.E., Park,H., Kim,T.H. and Kang,T.C. LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC K
Kim,Y.H., Hwang,J.S., Yoon,I.N., Lee,J.H., Lee,J., Park,K.C., Seok,H. and Kim,H. The insect peptide CopA3 blocks programmed cell death by directly binding caspases and inhibiting their proteolytic activation Biochem Biophys Res Commun (2021) 547, 82-88. PubMed Europe PubMed DOI
Maluch,I., Grzymska,J., Snipas,S.J., Salvesen,G.S. and Drag,M. Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7 Biochem J (2021) 478, 2233-2245. PubMed Europe PubMed DOI
Mao,Y., Qiao,J.D., Chen,S., Zhou,X., Wang,Z., Cai,S., Li,L. and Luo,Y. Kallistatin Inhibits Anoikis Resistance and Metastasis of Ectopic Endometrium Cells by Modulating MnSOD and Caspase 3 Signaling Reprod Sci (2021) PubMed Europe PubMed DOI
Ozdemir,A., Ibisoglu,B., Simay Demir,Y.D., Benhur,E., Valipour,F. and Ark,M. A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2 Biochem Biophys Res Commun (2021) 547, 118-124. PubMed Europe PubMed DOI
Shao,B., Zheng,L., Shi,J. and Sun,N. Acetylation of ANXA1 reduces caspase-3 activation by enhancing the phosphorylation of caspase-9 under OGD/R conditions Cell Signal (2021) 88, 110157-110157. PubMed Europe PubMed DOI
Soni,I.V. and Hardy,J.A. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence Biochemistry (2021) 60, 2824-2835. PubMed Europe PubMed DOI
Voss,T.D., Gerget,M., Linkus,B., von Einem,B., Landwehrmeyer,G.B. and Lewerenz,J. Ubiquitination and the Proteasome rather than Caspase-3-Mediated C-Terminal Cleavage are Involved in the EAAT2 Degradation by Staurosporine-Induced Cellular Stress J Neurochem (2021) 157, 1284-1299. PubMed Europe PubMed DOI
Zhang,L.S., Xu,H.L., Xia,Y., Bi,J.P., Zhang,C.Z., Xi,Z., Li,L.Y. and Zhang,Z.S. Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells Chem Commun (Camb) (2021) 57, 797-800. PubMed Europe PubMed DOI
Zhang,Z., Bao,X. and Li,D. Batroxobin inhibits astrocyte activation following nigrostriatal pathway injury Neural Regen Res (2021) 16, 721-726. PubMed Europe PubMed DOI

2020

Akhigbe,R.E., Ajayi,L.O., Adelakun,A.A., Olorunnisola,O.S. and Ajayi,A.F. Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis Mol Biol Rep (2020) 47, 9521-9530. PubMed Europe PubMed DOI
Akpinar,O., Ozsimsek,A., Guzel,M. and Naziroglu,M. Clostridium botulinum neurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells J Recept Signal Transduct Res (2020) , 1-13. PubMed Europe PubMed DOI
Almeida,C.P., Silveira,C.O., Ferreira,E.F., Ferreira,M.C., Oliveira,G.G., Veloso,E.S., Silva,F.H.S., Coelho,S.S., Moraes,L.M., Reis,F.M. and Del Puerto,H.L. Pro-caspase-3 is constitutively expressed in luteinized granulosa cells from women undergoing controlled ovarian stimulation for in vitro fertilization Acta Histochem (2020) 123, 151670-151670. PubMed Europe PubMed DOI
Ando,S., Tanaka,M., Chinen,N., Nakamura,S., Shimazawa,M. and Hara,H. SMN Protein Contributes to Skeletal Muscle Cell Maturation Via Caspase-3 and Akt Activation In Vivo (2020) 34, 3247-3254. PubMed Europe PubMed DOI
Balboula,A.Z., Schindler,K., Kotani,T., Kawahara,M. and Takahashi,M. Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytes Mol Hum Reprod (2020) PubMed Europe PubMed DOI
Benitez-Rangel,E., Olguin-Albuerne,M., Lopez-Mendez,M.C., Dominguez-Macouzet,G., Guerrero-Hernandez,A. and Moran,J. Caspase-3 Activation Correlates With the Initial Mitochondrial Membrane Depolarization in Neonatal Cerebellar Granule Neurons Front Cell Dev Biol (2020) 8, 544-544. PubMed Europe PubMed DOI PMC EPMC
Changizi,Z., Moslehi,A., Rohani,A.H. and Eidi,A. Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice J Biochem Mol Toxicol (2020) , e22642-e22642. PubMed Europe PubMed DOI
Chao,C.M., Chen,C.L., Niu,K.C., Lin,C.H., Tang,L.Y., Lin,L.S. and Chang,C.P. Hypobaric hypoxia preconditioning protects against hypothalamic neuron apoptosis in heat-exposed rats by reversing hypothalamic overexpression of matrix metalloproteinase-9 and ischemia Int J Med Sci (2020) 17, 2622-2634. PubMed Europe PubMed DOI PMC EPMC
Chen,X., Ji,S., Si,J., Zhang,X., Wang,X., Guo,Y. and Zou,X. Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis Mol Med Rep (2020) 22, 5243-5250. PubMed Europe PubMed DOI PMC EPMC
Chen,X., Chen,D., Huang,L., Chen,X., Zhou,M., Xi,X., Ma,C., Chen,T. and Wang,L. Identification and Target-Modification of SL-BBI: A Novel Bowman-Birk Type Trypsin Inhibitor from Sylvirana latouchii Biomolecules (2020) 10 PubMed Europe PubMed DOI
Chu,Y., Dong,X., Kang,Y., Liu,J., Zhang,T., Yang,C., Wang,Z., Shen,W., Huo,H., Zhuang,M., Lu,J. and Liu,Y. The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B iScience (2020) 23, 101708-101708. PubMed Europe PubMed DOI PMC EPMC K
Chuang,H.C., Chen,Y.Y., Hsiao,T.C., Chou,H.C., Kuo,H.P., Feng,P.H., Ho,S.C., Chen,J.K., Chuang,K.J. and Lee,K.Y. Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats ERJ Open Res (2020) 6 PubMed Europe PubMed DOI PMC EPMC
Corrigan,T.S., Lotti Diaz,L.M., Border,S.E., Ratigan,S.C., Kasper,K.Q., Sojka,D., Fajtova,P., Caffrey,C.R., Salvesen,G.S., McElroy,C.A., Hadad,C.M. and Dogan Ekici,O. Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors J Enzyme Inhib Med Chem (2020) 35, 1387-1402. PubMed Europe PubMed DOI I
Cui,X.Y., Park,S.H. and Park,W.H. Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspasedependent apoptosis Oncol Rep (2020) 44, 2715-2724. PubMed Europe PubMed DOI I
de Vasconcelos,N.M., Van Opdenbosch,N., Van Gorp,H., Martin-Perez,R., Zecchin,A., Vandenabeele,P. and Lamkanfi,M. An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages Cell Rep (2020) 32, 107959-107959. PubMed Europe PubMed DOI
Diao,W., Guo,Q., Zhu,C., Song,Y., Feng,H., Cao,Y., Du,M. and Chen,H. USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway BMC Cancer (2020) 20, 741-741. PubMed Europe PubMed DOI PMC EPMC
Ding,Z., Wei,Q., Zhang,C., Zhang,H. and Huang,F. Influence of oxidation on heat shock protein 27 translocation, caspase-3 and calpain activities and myofibrils degradation in postmortem beef muscles Food Chem (2020) 340, 127914-127914. PubMed Europe PubMed DOI
Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y. USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer Onco Targets Ther (2020) 13, 8495-8510. PubMed Europe PubMed DOI PMC EPMC L
Duan,L., Zuo,J., Zhang,F., Li,B., Xu,Z., Zhang,H., Yang,B., Song,W. and Jiang,J. Magnetic Targeting of HU-MSCs in the Treatment of Glucocorticoid-Associated Osteonecrosis of the Femoral Head Through Akt/Bcl2/Bad/Caspase-3 Pathway Int J Nanomedicine (2020) 15, 3605-3620. PubMed Europe PubMed DOI PMC EPMC
Eslami,F., Mahdavi,M., Babaei,E., Hussen,B.M., Mostafavi,H., Shahbazi,A. and Hidayat,H.J. Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family Toxicol Appl Pharmacol (2020) 409, 115331-115331. PubMed Europe PubMed DOI
Firoozpour,L., Gao,L., Moghimi,S., Pasalar,P., Davoodi,J., Wang,M.W., Rezaei,Z., Dadgar,A., Yahyavi,H., Amanlou,M. and Foroumadi,A. Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors J Enzyme Inhib Med Chem (2020) 35, 1674-1684. PubMed Europe PubMed DOI PMC EPMC I
Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J. Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection Fish Shellfish Immunol (2020) PubMed Europe PubMed DOI I
Fujisawa,Y., Shinoda,N., Chihara,T. and Miura,M. ROS Regulate Caspase-Dependent Cell Delamination without Apoptosis in the Drosophila Pupal Notum iScience (2020) 23, 101413-101413. PubMed Europe PubMed DOI PMC EPMC
Gao,H., Wen,N., Xu,X., Hong,G. and Lai,X. [Endoplasmic reticulum stress enhances tumor necrosis factor-alpha expression in rat Kupffer cells to trigger hepatic stellate apoptosis cell through TNFR/caspase-8 pathway] Nan Fang Yi Ke Da Xue Xue Bao (2020) 40, 632-639. PubMed Europe PubMed DOI PMC EPMC
Garcia-Arguello,S.F., Lopez-Lorenzo,B., Cornelissen,B. and Smith,G. Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI PMC EPMC V
Garcia-Dominguez,I., Suarez-Pereira,I., Santiago,M., Perez-Villegas,E.M., Bravo,L., Lopez-Martin,C., Roca-Ceballos,M.A., Garcia-Revilla,J., Espinosa-Oliva,A.M., Rodriguez-Gomez,J.A., Joseph,B., Berrocoso,E., Armengol,J.A., Venero,J.L., Ruiz,R. and de Pablos,R.M. Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour Prog Neuropsychopharmacol Biol Psychiatry (2020) 104, 110030-110030. PubMed Europe PubMed DOI K
Geng,D., Ciavattone,N., Lasola,J.J., Shrestha,R., Sanchez,A., Guo,J., Vlk,A., Younis,R., Wang,L., Brown,A.J., Zhang,Y., Velasco-Gonzalez,C., Tan,A.C. and Davila,E. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels Commun Biol (2020) 3, 306-306. PubMed Europe PubMed DOI PMC EPMC
Gu,J., Zhan,A.J., Jiang,J.L., Chen,Y., Xu,J., Ye,L. and Mao,M.G. Conserved function of Pacific cod caspase-3 in apoptosis Gene (2020) 732, 144370-144370. PubMed Europe PubMed DOI
Guo,X., Bai,X., Zhang,F., Zheng,L., Ding,W. and Yang,S. Resveratrol protects against apoptosis induced by interleukin-1beta in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3beta/caspase-3 pathways Biosci Rep (2020) 40 PubMed Europe PubMed DOI PMC EPMC I
Haque,M.E., Akther,M., Azam,S., Choi,D.K. and Kim,I.S. GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Hu,Y., Ma,Z., Chen,Z. and Chen,B. USP47 promotes apoptosis in rat myocardial cells after ischemia/reperfusion injury via NF-kappaB activation Biotechnol Appl Biochem (2020) PubMed Europe PubMed DOI K
Huo,W., Yu,J., Liu,C., Wu,T., Wang,Y., Meng,X., Song,F., Zhang,S., Su,Y., Liu,Y., Liu,J., Yu,X. and Hua,S. Caspase-3 inhibitor inhibits enterovirus D68 production J Microbiol (2020) 58, 812-820. PubMed Europe PubMed DOI PMC EPMC I
Ismy,J., Sugandi,S., Rachmadi,D., Hardjowijoto,S. and Mustafa,A. The Effect of Exogenous Superoxide Dismutase (SOD) on Caspase-3 Activation and Apoptosis Induction in Pc-3 Prostate Cancer Cells Res Rep Urol (2020) 12, 503-508. PubMed Europe PubMed DOI PMC EPMC
Jantas,D., Chwastek,J., Malarz,J., Stojakowska,A. and Lason,W. Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition Biomolecules (2020) 10 PubMed Europe PubMed DOI
Jin,B., Liu,J., Gao,D., Xu,Y., He,L., Zang,Y., Li,N. and Lin,D. Detailed studies on the anticancer action of rosmarinic acid in human Hep-G2 liver carcinoma cells: evaluating its effects on cellular apoptosis, caspase activation and suppression of cell migration and invasion J BUON (2020) 25, 1383-1389. PubMed Europe PubMed
Jin,Q., Lin,C., Zhu,X., Cao,Y., Guo,C. and Wang,L. (125)I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts Radiat Oncol (2020) 15, 238-238. PubMed Europe PubMed DOI PMC EPMC
Ke,H., Wang,X., Zhou,Z., Ai,W., Wu,Z. and Zhang,Y. Effect of weimaining on apoptosis and Caspase-3 expression in a breast cancer mouse model J Ethnopharmacol (2020) 264, 113363-113363. PubMed Europe PubMed DOI
Kirubhanand,C., Selvaraj,J., Rekha,U.V., Vishnupriya,V., Nalini,D., Mohan,S.K., Vijayalakshmi,P., Rajalakshmi,M. and Ponnulakshmi,R. Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9 Bioinformation (2020) 16, 458-461. PubMed Europe PubMed DOI PMC EPMC
Liang,H., Li,F., Li,H., Wang,R. and Du,M. Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase1/IL1beta Signaling Pathway Inhibition Immunol Invest (2020) , 1-14. PubMed Europe PubMed DOI I
Linares,G.R., Leng,Y., Maric,D. and Chuang,D.M. Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation Cell Biol Int (2020) PubMed Europe PubMed DOI
Liu,L., Chen,M., Lin,K., Xiang,X., Zheng,Y. and Zhu,S. Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes Int J Med Sci (2020) 17, 1936-1945. PubMed Europe PubMed DOI PMC EPMC
Liu,X., Bian,H., Dou,Q.L., Huang,X.W., Tao,W.Y., Liu,W.H., Li,N. and Zhang,W.W. Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway Biomed Res Int (2020) 2020, 1928410-1928410. PubMed Europe PubMed DOI PMC EPMC
Lopatniuk,P., Puchalska,Z., Mital,A., Mikosik,A., Frackowiak,J., Hellmann,A., Daca,A., Bryl,E., Fulop,T. and Witkowski,J.M. Excessive amount and activity of mu-calpain affects apoptotic machinery in chronic B-cell leukemia cells and influences the course of the disease Acta Biochim Pol (2020) 67, 247-257. PubMed Europe PubMed DOI
Loreto,C., Ledda,C., Tumino,R., Lombardo,C., Vitale,E., Filetti,V., Caltabiano,R. and Rapisarda,V. Activation of caspase-3 in malignant mesothelioma induced by asbestiform fiber: an in vivo study J Biol Regul Homeost Agents (2020) 34, 1163-1166. PubMed Europe PubMed DOI
Lozeie,M., Bagheri,M., Rad,I.A., Hossein-Zadeh,N. and Nasir-Zadeh,M. Zinc attenuates ecstasy-induced apoptosis through downregulation of caspase-3 in cultured TM3 cells: An experimental study Int J Reprod Biomed (2020) 18, 777-784. PubMed Europe PubMed DOI PMC EPMC
Masood,N., Dubey,V. and Luqman,S. Activation of caspase-3 by terpenoids and flavonoids in different types of cancer cells Curr Top Med Chem (2020) PubMed Europe PubMed DOI
McKenzie,B.A., Fernandes,J.P., Doan,M.A.L., Schmitt,L.M., Branton,W.G. and Power,C. Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis J Neuroinflammation (2020) 17, 253-253. PubMed Europe PubMed DOI PMC EPMC K
Negara,K.S., Suwiyoga,K., Sudewi,R., Astawa,N.M., Arijana,G.N.K., Tunas,K. and Pemayun,T.G.A. The role of caspase-dependent and caspase-independent pathways of apoptosis in the premature rupture of the membranes: A case-control study Int J Reprod Biomed (Yazd) (2020) 18, 439-448. PubMed Europe PubMed DOI PMC EPMC
Nerlich,A., von Wunsch Teruel,I., Mieth,M., Honzke,K., Ruckert,J.C., Mitchell,T.J., Suttorp,N., Hippenstiel,S. and Hocke,A.C. Reversion of pneumolysin induced executioner caspase activation redirects cells to survival J Infect Dis (2020) PubMed Europe PubMed DOI
Nichani,K., Li,J., Suzuki,M. and Houston,J.P. Evaluation of Caspase-3 Activity During Apoptosis with Fluorescence Lifetime-Based Cytometry Measurements and Phasor Analyses Cytometry A (2020) PubMed Europe PubMed DOI
Noori,A.R., Tashakor,A., Nikkhah,M., Eriksson,L.A., Hosseinkhani,S. and Fearnhead,H.O. Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9 Biochimie (2020) 180, 23-29. PubMed Europe PubMed DOI
Otaka,N., Uchida,H.A., Okuyama,M., Hada,Y., Onishi,Y., Kakio,Y., Takeuchi,H., Umebayashi,R., Tanabe,K., Subramanian,V., Daugherty,A., Sato,Y. and Wada,J. Vasohibin-2 Aggravates Development of Ascending Aortic Aneurysms But Not Abdominal Aortic Aneurysms Nor Atherosclerosis in ApoE Deficient Mice Am J Hypertens (2020) PubMed Europe PubMed DOI
Padmanabha,S. and Vallikannan,B. Fatty acids influence the efficacy of lutein in the modulation of alpha-crystallin chaperone function: Evidence from selenite induced cataract rat model Biochem Biophys Res Commun (2020) 529, 425-431. PubMed Europe PubMed DOI
Park,G., Nhan,H.S., Tyan,S.H., Kawakatsu,Y., Zhang,C., Navarro,M. and Koo,E.H. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease Cell Rep (2020) 31, 107839-107839. PubMed Europe PubMed DOI
Salama,R.M., Mohamed,A.M., Hamed,N.S., Ata,R.M., NourelDeen,A.S. and Hassan,M.A. Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway Toxicol Res (Camb) (2020) 9, 561-568. PubMed Europe PubMed DOI PMC EPMC I
Shokry,D.A., El Nabrawy,N., Yassa,H.D., Gaber,S.S., Batiha,G.E. and Welson,N.N. Pregabalin induced reproductive toxicity and body weight changes by affecting caspase3 and leptin expression: Protective role of wheat germ oil Life Sci (2020) 260, 118344-118344. PubMed Europe PubMed DOI
Sibarani,J., Tjahjodjati,T., Atik,N., Rachmadi,D. and Mustafa,A. Urinary Cytochrome C and Caspase-3 as Novel Biomarker of Renal Function Impairment in Unilateral Ureteropelvic Junction Obstruction Model of Wistar Rats Res Rep Urol (2020) 12, 217-224. PubMed Europe PubMed DOI PMC EPMC
Song,X., Tang,Y., Zhu,J., Tian,Y., Song,Z., Hu,X., Hong,C., Cai,Y. and Kang,F. HIF-1alpha induces hypoxic apoptosis of MLO-Y4 osteocytes via JNK/caspase-3 pathway and the apoptotic-osteocyte-mediated osteoclastogenesis in vitro Tissue Cell (2020) 67, 101402-101402. PubMed Europe PubMed DOI K
Taki,K., Horie,T., Kida,T., Mimura,M., Ikeda,T. and Oku,H. Impairment of Autophagy Causes Superoxide Formation and Caspase Activation in 661 W Cells, a Cell Line for Cone Photoreceptors, under Hyperglycemic Conditions Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Tang,J., Chen,R., Wang,L., Yu,L., Zuo,D., Cui,G. and Gong,X. Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis Inflammation (2020) 43, 1959-1970. PubMed Europe PubMed DOI
Wang,Y., Sun,H., Zhang,J., Xia,Z. and Chen,W. Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways Biosci Biotechnol Biochem (2020) , 1-12. PubMed Europe PubMed DOI
Wang,Y.J., Liu,M.G., Wang,J.H., Cao,W., Wu,C., Wang,Z.Y., Liu,L., Yang,F., Feng,Z.H., Sun,L., Zhang,F., Shen,Y., Zhou,Y.D., Zhuo,M., Luo,J.H., Xu,T.L. and Li,X.Y. Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity Cell Rep (2020) 33, 108369-108369. PubMed Europe PubMed DOI
Wolin,I.A.V., Heinrich,I.A., Nascimento,A.P.M., Welter,P.G., Sosa,L.D.V., De Paul,A.L., Zanotto-Filho,A., Nedel,C.B., Lima,L.D., Osterne,V.J.S., Pinto-Junior,V.R., Nascimento,K.S., Cavada,B.S. and Leal,R.B. ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation Biochimie (2020) 180, 186-204. PubMed Europe PubMed DOI
Xiao,Y., Deng,T. and Wang,D. Davanone terpenoid inhibits cisplatin-resistant acute myeloid leukemia cancer cell growth by inducing caspase-dependent apoptosis, loss of mitochondrial membrane potential, inhibition of cell migration and invasion and targeting PI3K/AKT/MAPK signalling pathway J BUON (2020) 25, 1607-1613. PubMed Europe PubMed
Yan,M., Chen,J., Jiang,H., Xie,Y., Li,C., Chen,L., Yang,B. and Cao,J. Effective inhibition of cancer cells by recombinant adenovirus expressing EGFR-targeting artificial microRNA and reversed-caspase-3 PLoS ONE (2020) 15, e0237098-e0237098. PubMed Europe PubMed DOI PMC EPMC
Yang,L., Eberwine,J.H. and Dmochowski,I.J. Caspase-Activated Oligonucleotide Probe Bioconjug Chem (2020) 31, 2172-2178. PubMed Europe PubMed DOI K
Yardim,A., Kandemir,F.M., Ozdemir,S., Kucukler,S., Comakli,S., Gur,C. and Celik,H. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways Neurotoxicology (2020) 81, 137-146. PubMed Europe PubMed DOI I
Yossef,R.R., Al-Yamany,M.F., Saad,M.A. and El-Sahar,A.E. Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: Role of hippocampal klotho and AKT signaling pathways Eur J Pharmacol (2020) 889, 173612-173612. PubMed Europe PubMed DOI I
Yu,H., Sun,Q., Yun,F., Xu,X., Ding,F., Li,S. and Zhao,P. XCHD Inhibits C6 Cell Growth Primarily via the p53/Caspase Pathway Evid Based Complement Alternat Med (2020) 2020, 7973639-7973639. PubMed Europe PubMed DOI PMC EPMC
Yu,Q.S., Xin,H.R., Qiu,R.L., Deng,Z.L., Deng,F. and Yan,Z.J. Niclosamide: drug repurposing for human chondrosarcoma treatment via the caspase-dependent mitochondrial apoptotic pathway Am J Transl Res (2020) 12, 3688-3701. PubMed Europe PubMed PMC EPMC
Yu,Y., Zhang,Y., Zhang,J., Guan,C., Liu,L. and Ren,L. Cantharidin-induced acute hepatotoxicity: the role of TNF-alpha, IKK-alpha, Bcl-2, Bax and caspase3 J Appl Toxicol (2020) 40, 1526-1533. PubMed Europe PubMed DOI
Zhang,J.W., Long,T.Y., Pan,W., Zhong,Q.Q., Qian,Z.X. and Jing,R. MiR-808 inhibits cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction by regulating TGF-beta1 signaling pathway Eur Rev Med Pharmacol Sci (2020) 24, 6955-6960. PubMed Europe PubMed DOI I
Zhang,Y., Chen,Z., Li,X., He,J., Liu,Z. and Yang,L. Baicalein flavone targets cisplatin resistant human pancreatic cancer cells via inducing S-phase cell cycle arrest, inhibition of cell migration and invasion, caspase activation and mitochondrial-dependent apoptosis J BUON (2020) 25, 1947-1953. PubMed Europe PubMed
Zhao,F., Li,J., Lu,Q., Chen,E. and Yuan,L. [Danggui Niantong decoction induces apoptosis by activating Fas/caspase-8 pathway in rheumatoid arthritis fibroblast-like synoviocytes] Nan Fang Yi Ke Da Xue Xue Bao (2020) 40, 1119-1126. PubMed Europe PubMed DOI PMC EPMC
Zheng,K., Li,Q., Lin,D., Zong,X., Luo,X., Yang,M., Yue,X. and Ma,S. Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites Food Funct (2020) 11, 7481-7494. PubMed Europe PubMed DOI
Zhou,Y., Cheng,X., Wan,Y., Chen,T., Zhou,Q., Wang,Z. and Zhu,H. MicroRNA-421 Inhibits Apoptosis by Downregulating Caspase-3 in Human Colorectal Cancer Cancer Manag Res (2020) 12, 7579-7587. PubMed Europe PubMed DOI PMC EPMC

2019

Expression of Concern: alpha-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3 Biosci Rep (2019) 40 PubMed Europe PubMed DOI
Checker,R., Pal,D., Patwardhan,R.S., Basu,B., Sharma,D. and Sandur,S.K. Modulation of caspase-3 activity using a redox active vitamin K3 analogue, plumbagin, as a novel strategy for radioprotection Free Radic Biol Med (2019) 143, 560-572. PubMed Europe PubMed DOI I
Chen,Y.L., Han,K., Huang,X., Zhang,Z., Wan,X. and Ren,Q. Caspase-3C gene from red swamp crayfish, Procambarus clarki: characterization and expression in response to pathogenic infection Fish Shellfish Immunol (2019) 94, 792-799. PubMed Europe PubMed DOI
Clark,A.M., Ponniah,K., Warden,M.S., Raitt,E.M., Smith,B.G. and Pascal,S.M. Tetramer formation by the caspase-activated fragment of the Par-4 tumor suppressor FEBS J (2019) 286, 4060-4073. PubMed Europe PubMed DOI
Eda,S.R., Veeramachaneni,G.K., Bondili,J.S. and Jinka,R. Screening of caspase-3 inhibitors from natural molecule database using e-pharmacophore and docking studies Bioinformation (2019) 15, 240-245. PubMed Europe PubMed DOI PMC EPMC I
Huan,L.C., Phuong,C.V., Truc,L.C., Thanh,V.N., Pham-The,H., Huong,L.T., Thuan,N.T., Park,E.J., Ji,A.Y., Kang,J.S., Han,S.B., Tran,P.T. and Nam,N.H. (E)-N'-Arylidene-2-(4-oxoquinazolin-4(3H)-yl) acetohydrazides: synthesis and evaluation of antitumor cytotoxicity and caspase activation activity J Enzyme Inhib Med Chem (2019) 34, 465-478. PubMed Europe PubMed DOI PMC EPMC
Kashaw,S.K., Agarwal,S., Mishra,M., Sau,S. and Iyer,A.K. Molecular docking analysis of caspase-3 activators as potential anticancer agents Curr Comput Aided Drug Des (2019) 15, 55-66. PubMed Europe PubMed DOI
Ostapchenko,V.G., Snir,J., Suchy,M., Fan,J., Cobb,M.R., Chronik,B.A., Kovacs,M., Prado,V.F., Hudson,R.H.E., Pasternak,S.H., Prado,M.A.M. and Bartha,R. Detection of active caspase-3 in mouse models of stroke and Alzheimer's disease with a novel dual positron emission tomography/fluorescent tracer [(68)Ga]Ga-TC3-OGDOTA Contrast Media Mol Imaging (2019) 2019, 6403274-6403274. PubMed Europe PubMed DOI PMC EPMC L
Patel,S., Wall,D.M., Castillo,A. and McCormick,B.A. Caspase-3 cleavage of Salmonella type III secreted effector protein SifA is required for localization of functional domains and bacterial dissemination Gut Microbes (2019) 10, 172-187. PubMed Europe PubMed DOI
Piechowska,K., Switalska,M., Cytarska,J., Jaroch,K., Luczykowski,K., Chalupka,J., Wietrzyk,J., Misiura,K., Bojko,B., Kruszewski,S. and Laczkowski,K.Z. Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: rational design, one-pot tricomponent synthesis, and lipophilicity determination Eur J Med Chem (2019) 175, 162-171. PubMed Europe PubMed DOI
Ponder,K.G. and Boise,L.H. The prodomain of caspase-3 regulates its own removal and caspase activation Cell Death Discov (2019) 5, 56-56. PubMed Europe PubMed DOI PMC EPMC
Solania,A., Gonzalez-Paez,G.E. and Wolan,D.W. Selective and rapid cell-permeable inhibitor of human caspase-3 ACS Chem Biol (2019) 14, 2463-2470. PubMed Europe PubMed DOI I
Van Kersavond,T., Konopatzki,R., Chakrabarty,S., Blank-Landeshammer,B., Sickmann,A. and Verhelst,S.H.L. Short peptides with uncleavable peptide bond mimetics as photoactivatable caspase-3 inhibitors Molecules (2019) 24 PubMed Europe PubMed DOI I
Wagner,H.J. and Weber,W. Design of a human rhinovirus-14 3C protease-inducible caspase-3 Molecules (2019) 24 PubMed Europe PubMed DOI
Wang,Y., Hu,X., Weng,J., Li,J., Fan,Q., Zhang,Y. and Ye,D. A photoacoustic probe for the imaging of tumor apoptosis by caspase-mediated macrocyclization and self-assembly Angew Chem Int Ed Engl (2019) 58, 4886-4890. PubMed Europe PubMed DOI L
Zhang,Q., Schepis,A., Huang,H., Yang,J., Ma,W., Torra,J., Zhang,S.Q., Yang,L., Wu,H., Nonell,S., Dong,Z., Kornberg,T.B., Coughlin,S.R. and Shu,X. Designing a green fluorogenic protease reporter by flipping a beta strand of GFP for imaging apoptosis in animals J Am Chem Soc (2019) 141, 4526-4530. PubMed Europe PubMed DOI L
Zhao,C., Qiu,L., Lv,P., Han,A., Fang,G., Liu,J. and Wang,S. AuNP-peptide probe for caspase-3 detection in living cells by SERS Analyst (2019) 144, 1275-1281. PubMed Europe PubMed DOI L

2018

Akazawa,K., Sugihara,F., Nakamura,T., Mizukami,S. and Kikuchi,K. Highly sensitive detection of caspase-3/7 activity in living mice using enzyme-responsive (19)F MRI nanoprobes Bioconjug Chem (2018) 29, 1720-1728. PubMed Europe PubMed DOI L
Buschhaus,J.M., Humphries,B., Luker,K.E. and Luker,G.D. A caspase-3 reporter for fluorescence lifetime imaging of single-cell apoptosis Cells (2018) 7 PubMed Europe PubMed DOI PMC EPMC L
Engel,B.J., Gammon,S.T., Chaudhari,R., Lu,Z., Pisaneschi,F., Yang,H., Ornelas,A., Yan,V., Kelderhouse,L., Najjar,A.M., Tong,W.P., Zhang,S., Piwnica-Worms,D., Bast RC Jr and Millward,S.W. Caspase-3 substrates for noninvasive pharmacodynamic imaging of apoptosis by PET/CT Bioconjug Chem (2018) 29, 3180-3195. PubMed Europe PubMed DOI L
Herr,A.B. Evolution of an allosteric "off switch" in apoptotic caspases J Biol Chem (2018) 293, 5462-5463. PubMed Europe PubMed DOI PMC EPMC
Pal,A. and Rehemtulla,A. Imaging proteolytic activities in mouse models of cancer (2018) 1731, 247-260. PubMed Europe PubMed DOI L
Qin,X., Lyu,M., Si,Y., Yang,J., Wu,Z. and Li,J. Alkyne-based surface-enhanced Raman scattering nanoprobe for ratiometric imaging analysis of caspase 3 in live cells and tissues Anal Chim Acta (2018) 1043, 115-122. PubMed Europe PubMed DOI L
Thomas ME 3rd, Grinshpon,R., Swartz,P. and Clark,A.C. Modifications to a common phosphorylation network provide individualized control in caspases J Biol Chem (2018) 293, 5447-5461. PubMed Europe PubMed DOI PMC EPMC
Victor,K.G., Heffron,D.S., Sokolowski,J.D., Majumder,U., LeBlanc,A. and Mandell,J.W. Proteomic identification of synaptic caspase substrates Synapse (2018) 72 PubMed Europe PubMed DOI P
Wong,K.S., Mabanglo,M.F., Seraphim,T.V., Mollica,A., Mao,Y.Q., Rizzolo,K., Leung,E., Moutaoufik,M.T., Hoell,L., Phanse,S., Goodreid,J., Barbosa,L.R.S., Ramos,C.H.I., Babu,M., Mennella,V., Batey,R.A., Schimmer,A.D. and Houry,W.A. Acyldepsipeptide analogs dysregulate human mitochondrial ClpP protease activity and cause apoptotic cell death Cell Chem Biol (2018) 25, 1017-1030. PubMed Europe PubMed DOI
Yang,B., Lan,S., Dieude,M., Sabo-Vatasescu,J.P., Karakeussian-Rimbaud,A., Turgeon,J., Qi,S., Gunaratnam,L., Patey,N. and Hebert,M.J. Caspase-3 is a pivotal regulator of microvascular rarefaction and renal fibrosis after ischemia-reperfusion injury J Am Soc Nephrol (2018) 29, 1900-1916. PubMed Europe PubMed DOI
Yang,R., Li,Y., Zou,K., Meng,L., Zhang,X. and Chen,J. A label-free and blocker-free photoelectrochemical strategy for highly sensitive caspase-3 assay Chem Commun (Camb) (2018) 54, 4830-4833. PubMed Europe PubMed DOI A
Zherdeva,V., Kazachkina,N.I., Shcheslavskiy,V. and Savitsky,A.P. Long-term fluorescence lifetime imaging of a genetically encoded sensor for caspase-3 activity in mouse tumor xenografts J Biomed Opt (2018) 23, 1-11. PubMed Europe PubMed DOI L

2017

Cheng,H., Li,S.Y., Zheng,H.R., Li,C.X., Xie,B.R., Chen,K.W., Li,B. and Zhang,X.Z. Multi-Forster resonance energy transfer-based fluorescent probe for spatiotemporal matrix metalloproteinase-2 and caspase-3 imaging Anal Chem (2017) 89, 4349-4354. PubMed Europe PubMed DOI L
Poreba,M., Salvesen,G.S. and Drag,M. Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity Nat Protoc (2017) 12, 2189-2214. PubMed Europe PubMed DOI P I
Rogers,C., Fernandes-Alnemri,T., Mayes,L., Alnemri,D., Cingolani,G. and Alnemri,E.S. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death Nat Commun (2017) 8, 14128-14128. PubMed Europe PubMed DOI PMC EPMC
Rosenblum,L.T., Shamamandri-Markandaiah,S., Ghosh,B., Foran,E., Lepore,A.C., Pasinelli,P. and Trotti,D. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS Exp Neurol (2017) 292, 145-153. PubMed Europe PubMed DOI
Shen,X., Burguillos,M.A. and Joseph,B. Guilt by association, caspase-3 regulates microglia polarization Cell Cycle (2017) 16, 306-307. PubMed Europe PubMed DOI
Smart,A.D., Pache,R.A., Thomsen,N.D., Kortemme,T., Davis,G.W. and Wells,J.A. Engineering a light-activated caspase-3 for precise ablation of neurons in vivo Proc Natl Acad Sci U S A (2017) 114, E8174-E8174. PubMed Europe PubMed DOI
Su,D., Hu,X., Dong,C. and Ren,J. Determination of caspase-3 activity and its inhibition constant by combination of fluorescence correlation spectroscopy with a microwell chip Anal Chem (2017) 89, 9788-9796. PubMed Europe PubMed DOI A
Vaidya,A., Jain,A.K., Prashantha Kumar,B.R., Sastry,G.N., Kashaw,S.K. and Agrawal,R.K. CoMFA, CoMSIA, kNN MFA and docking studies of 1,2,4-oxadiazole derivatives as potent caspase-3 activators Arab J Chem (2017) 10, S3936-S3946. DOI
Wang,Y., Gao,W., Shi,X., Ding,J., Liu,W., He,H., Wang,K. and Shao,F. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin Nature (2017) 547, 99-103. PubMed Europe PubMed DOI
Yang,Y., Liang,Y. and Zhang,C.Y. Label-free and homogenous detection of caspase-3-like proteases by disrupting homodimerization-directed bipartite tetracysteine display Anal Chem (2017) 89, 4055-4061. PubMed Europe PubMed DOI A

2016

Baek,H.J., Lee,Y.M., Kim,T.H., Kim,J.Y., Park,E.J., Iwabuchi,K., Mishra,L. and Kim,S.S. Caspase-3/7-mediated cleavage of beta2-spectrin is required for acetaminophen-induced liver damage Int J Biol Sci (2016) 12, 172-183. PubMed Europe PubMed DOI PMC EPMC
Burgess,J.T., Bolderson,E., Adams,M.N., Baird,A.M., Zhang,S.D., Gately,K.A., Umezawa,K., O'Byrne,K.J. and Richard,D.J. Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response Cell Death Dis (2016) 7, e2469-e2469. PubMed Europe PubMed DOI
Hajimahdi,Z., Safizadeh,F. and Zarghi,A. Qsar analysis for some 1, 2-benzisothiazol-3-one derivatives as caspase-3 inhibitors by stepwise mlr method Iran J Pharm Res (2016) 15, 439-448. PubMed Europe PubMed I
Hwang,D., Kim,S.A., Yang,E.G., Song,H.K. and Chung,H.S. A facile method to prepare large quantities of active caspase-3 overexpressed by auto-induction in the C41(DE3) strain Protein Expr Purif (2016) 126, 104-108. PubMed Europe PubMed DOI E
Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed Europe PubMed DOI P
Khalilzadeh,B., Charoudeh,H.N., Shadjou,N., Mohammad-Rezaei,R., Omidi,Y., Velaei,K., Aliyari,Z. and Rashidi,M.-R. Ultrasensitive caspase-3 activity detection using an electrochemical biosensor engineered by gold nanoparticle functionalized MCM-41: Its application during stem cell differentiation Sens Actuators, B Chem (2016) 231, 561-575. DOI A
Maciag,J.J., MacKenzie,S.H., Tucker,M.B., Schipper,J.L., Swartz,P. and Clark,A.C. Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection Proc Natl Acad Sci U S A (2016) 113, E6080-E6080. PubMed Europe PubMed DOI S
Mackay,M., Perez-Lopez,A.M., Bradley,M. and Lilienkampf,A. Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates Mol Biosyst (2016) 12, 693-696. PubMed Europe PubMed DOI A
Perez-Lopez,A.M., Soria-Gila,M.L., Marsden,E.R., Lilienkampf,A. and Bradley,M. Fluorogenic substrates for in situ monitoring of caspase-3 activity in live cells PLoS ONE (2016) 11, e0153209-e0153209. PubMed Europe PubMed DOI PMC EPMC A L
Seaman,J.E., Julien,O., Lee,P.S., Rettenmaier,T.J., Thomsen,N.D. and Wells,J.A. Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues Cell Death Differ (2016) 23, 1717-1726. PubMed Europe PubMed DOI P
To,T.L., Schepis,A., Ruiz-Gonzalez,R., Zhang,Q., Yu,D., Dong,Z., Coughlin,S.R. and Shu,X. Rational design of a GFP-based fluorogenic caspase reporter for imaging apoptosis in vivo Cell Chem Biol (2016) 23, 875-882. PubMed Europe PubMed DOI L
Tucker,M.B., MacKenzie,S.H., Maciag,J.J., Dirscherl Ackerman,H., Swartz,P., Yoder,J.A., Hamilton,P.T. and Clay Clark,A. Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish Protein Sci (2016) 25, 2076-2088. PubMed Europe PubMed DOI P S
Wang,C., Ye,M., Wei,X., Bian,Y., Cheng,K. and Zou,H. A bead-based cleavage method for large-scale identification of protease substrates Sci Rep (2016) 6, 22645-22645. PubMed Europe PubMed DOI PMC EPMC P
Zlobovskaya,O.A., Sergeeva,T.F., Shirmanova,M.V., Dudenkova,V.V., Sharonov,G.V., Zagaynova,E.V. and Lukyanov,K.A. Genetically encoded far-red fluorescent sensors for caspase-3 activity Biotechniques (2016) 60, 62-68. PubMed Europe PubMed DOI L

2015

Alasia,S., Cocito,C., Merighi,A. and Lossi,L. Real-time visualization of caspase-3 activation by fluorescence resonance energy transfer (FRET) Methods Mol Biol (2015) 1254, 99-113. PubMed Europe PubMed DOI L
Cailliau,K., Lescuyer,A., Burnol,A.F., Cuesta-Marban,A., Widmann,C. and Browaeys-Poly,E. RasGAP shields Akt from deactivating phosphatases in fibroblast growth factor signaling but loses this ability once cleaved by caspase-3 J Biol Chem (2015) 290, 19653-19665. PubMed Europe PubMed DOI P
Chen,B., Ning,J.L., Gu,J.T., Cui,J., Yang,Y., Wang,Z., Zeng,J., Yi,B. and Lu,K.Z. Caspase-3 inhibition prevents the development of hepatopulmonary syndrome in common bile duct ligation rats by alleviating pulmonary injury Liver Int (2015) 35, 1373-1382. PubMed Europe PubMed DOI I
Chen,D.L., Engle,J.T., Griffin,E.A., Miller,J.P., Chu,W., Zhou,D. and Mach,R.H. Imaging caspase-3 activation as a marker of apoptosis-targeted treatment response in cancer Mol Imaging Biol (2015) 17, 384-393. PubMed Europe PubMed DOI L
Chen,H., Zhang,J., Gao,Y., Liu,S., Koh,K., Zhu,X. and Yin,Y. Sensitive cell apoptosis assay based on caspase-3 activity detection with graphene oxide-assisted electrochemical signal amplification Biosens Bioelectron (2015) 68C, 777-782. PubMed Europe PubMed DOI A
Chu,J., Li,J.G., Joshi,Y.B., Giannopoulos,P.F., Hoffman,N.E., Madesh,M. and Pratico,D. Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease Biol Psychiatry (2015) 77, 720-728. PubMed Europe PubMed DOI
Dick,S.A., Chang,N.C., Dumont,N.A., Bell,R.A.V., Putinski,C., Kawabe,Y., Litchfield,D.W., Rudnicki,M.A. and Megeney,L.A. Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells Proc Natl Acad Sci U S A (2015) 112, E5246-E5252. PubMed Europe PubMed DOI
Ferrucci,A., Leboffe,L., Agamennone,M., Di Pizio,A., Fiocchetti,M., Marino,M., Ascenzi,P. and Luisi,G. Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies Amino Acids (2015) 47, 153-162. PubMed Europe PubMed DOI I
Goryashchenko,A.S., Khrenova,M.G., Bochkova,A.A., Ivashina,T.V., Vinokurov,L.M. and Savitsky,A.P. Genetically encoded FRET-sensor based on terbium chelate and red fluorescent protein for detection of caspase-3 activity Int J Mol Sci (2015) 16, 16642-16654. PubMed Europe PubMed DOI PMC EPMC L
Hung,V.W.S., Veloso,A.J., Chow,A.M., Ganesh,H.V.S., Seo,K., Kenduzler,E., Brown,I.R. and Kerman,K. Electrochemical impedance spectroscopy for monitoring caspase-3 activity Electrochim Acta (2015) 162, 79-85. DOI A
Kang,H.J., Kim,J.H. and Chung,S.J. Homogeneous detection of caspase-3 using intrinsic fluorescence resonance energy transfer (iFRET) Biosens Bioelectron (2015) 67, 413-418. PubMed Europe PubMed DOI A
Limpachayaporn,P., Schafers,M. and Haufe,G. Isatin sulfonamides: potent caspases-3 and -7 inhibitors, and promising PET and SPECT radiotracers for apoptosis imaging Future Med Chem (2015) 7, 1173-1196. PubMed Europe PubMed DOI L I
Nejadnik,H., Ye,D., Lenkov,O.D., Donig,J.S., Martin,J.E., Castillo,R., Derugin,N., Sennino,B., Rao,J. and Daldrup-Link,H. Magnetic resonance imaging of stem cell apoptosis in arthritic joints with a caspase activatable contrast agent ACS Nano (2015) 9, 1150-1160. PubMed Europe PubMed DOI L
Suzuki,M., Sakata,I., Sakai,T., Tomioka,H., Nishigaki,K., Tramier,M. and Coppey-Moisan,M. A high-throughput direct fluorescence resonance energy transfer-based assay for analyzing apoptotic proteases using flow cytometry and fluorescence lifetime measurements Anal Biochem (2015) 491, 10-17. PubMed Europe PubMed DOI L
To,T.L., Piggott,B.J., Makhijani,K., Yu,D., Jan,Y.N. and Shu,X. Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo Proc Natl Acad Sci U S A (2015) 112, 3338-3343. PubMed Europe PubMed DOI L
Udemba,A., Smith,G., Nguyen,Q.D., Kaliszczak,M., Carroll,L., Fortt,R., Fuchter,M.J. and Aboagye,E.O. Design, synthesis and initial characterisation of a radiolabelled [(18)F]pyrimidoindolone probe for detecting activated caspase-3/7 Org Biomol Chem (2015) 13, 5418-5423. PubMed Europe PubMed DOI L
Vagner,T., Mouravlev,A. and Young,D. A novel bicistronic sensor vector for detecting caspase-3 activation J Pharmacol Toxicol Methods (2015) 72C, 11-18. PubMed Europe PubMed DOI L
Waldmann,C.M., Hermann,S., Faust,A., Riemann,B., Schober,O., Schafers,M., Haufe,G. and Kopka,K. Novel fluorine-18 labeled 5-(1-pyrrolidinylsulfonyl)-7-azaisatin derivatives as potential PET tracers for in vivo imaging of activated caspases in apoptosis Bioorg Med Chem (2015) 23, 5734-5739. PubMed Europe PubMed DOI L
Wang,F., Liu,Y., Wang,L., Yang,J., Zhao,Y., Wang,N., Cao,Q., Gong,P. and Wu,C. Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis J Cell Mol Med (2015) 19, 1916-1928. PubMed Europe PubMed DOI
Wang,J., Zhang,L., Chen,M., Gao,S. and Zhu,L. Activatable ferritin nanocomplex for real-time monitoring of caspase-3 activation during photodynamic therapy ACS Appl Mater Interfaces (2015) 7, 23248-23256. PubMed Europe PubMed DOI L
Yuan,Y., Sun,H., Ge,S., Wang,M., Zhao,H., Wang,L., An,L., Zhang,J., Zhang,H., Hu,B., Wang,J. and Liang,G. Controlled intracellular self-assembly and disassembly of 19F nanoparticles for MR imaging of caspase 3/7 in zebrafish ACS Nano (2015) 9, 761-768. PubMed Europe PubMed DOI L

2014

Adamova,E., Liskova,M., Matalova,E. and Kleparnik,K. A miniaturized device for bioluminescence analysis of caspase-3/7 activity in a single apoptotic cell Anal Bioanal Chem (2014) 406, 5389-5394. PubMed Europe PubMed DOI L
Ahmad,K., Balaramnavar,V.M., Baig,M.H., Srivastava,A.K., Khan,S. and Kamal,M.A. Identification of potent caspase-3 inhibitors for treatment of multi-neurodegenerative diseases using pharmacophore modeling and docking approaches CNS Neurol Disord Drug Targets (2014) 13, 1346-1353. PubMed Europe PubMed I
Botham,R.C., Fan,T.M., Im,I., Borst,L.B., Dirikolu,L. and Hergenrother,P.J. Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity J Am Chem Soc (2014) 136, 1312-1319. PubMed Europe PubMed DOI
Cade,C., Swartz,P., MacKenzie,S.H. and Clark,A.C. Modifying caspase-3 activity by altering allosteric networks Biochemistry (2014) 53, 7582-7595. PubMed Europe PubMed DOI
Daniel,A.G., Peterson,E.J. and Farrell,N.P. The bioinorganic chemistry of apoptosis: potential inhibitory zinc binding sites in caspase-3 Angew Chem Int Ed Engl (2014) 53, 4098-4101. PubMed Europe PubMed DOI
Flutsch,A., Ackermann,R., Schroeder,T., Lukarska,M., Hausammann,G.J., Weinert,C., Briand,C. and Grutter,M.G. Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise Biochem J (2014) 461, 279-290. PubMed Europe PubMed DOI
Fu,S.C., Imai,K., Sawasaki,T. and Tomii,K. ScreenCap3: improving prediction of caspase-3 cleavage sites using experimentally verified noncleavage sites Proteomics (2014) 14, 2042-2046. PubMed Europe PubMed DOI P
Fuchs,J.E., von Grafenstein,S., Huber,R.G., Wallnoefer,H.G. and Liedl,K.R. Specificity of a protein-protein interface: local dynamics direct substrate recognition of effector caspases Proteins (2014) 82, 546-555. PubMed Europe PubMed DOI P
Guo,Z., Yan,Z., Zhou,X., Wang,Q., Lu,M., Liu,W., Zhou,H., Yang,C. and McClain,E.J. Synthesis and biological evaluation of novel 1,2-benzisothiazol-3-one-derived 1,2,3-triazoles as caspase-3 inhibitors Med Chem Res (2014) 24, 1814-1829. DOI I
Holland-Nell,K., Fernandez-Bachiller,M.I., Ahsanullah and Rademann,J. Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3 Org Lett (2014) 16, 4428-4431. PubMed Europe PubMed DOI I
Hong,Q., Yu,S., Yang,Y., Liu,G. and Shao,Z. A polymorphism in JMJD2C alters the cleavage by caspase-3 and the prognosis of human breast cancer Oncotarget (2014) 5, 4779-4787. PubMed Europe PubMed P
Ishimoto,T., Jigawa,K., Henares,T.G., Sueyoshi,K., Endo,T. and Hisamoto,H. Efficient immobilization of the enzyme and substrate for a single-step caspase-3 inhibitor assay using a combinable PDMS capillary sensor array RSC Adv (2014) 4, 7682-7687. DOI A I
Jolivel,V., Arthaud,S., Botia,B., Portal,C., Delest,B., Clave,G., Leprince,J., Romieu,A., Renard,P.Y., Touzani,O., Ligeret,H., Noack,P., Massonneau,M., Fournier,A., Vaudry,H. and Vaudry,D. Biochemical characterization of a caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis J Mol Neurosci (2014) 54, 451-462. PubMed Europe PubMed DOI L
Kavanagh,E., Rodhe,J., Burguillos,M.A., Venero,J.L. and Joseph,B. Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia Cell Death Dis (2014) 5, e1565-e1565. PubMed Europe PubMed DOI
Kelotra,S., Jain,M., Kelotra,A., Jain,I., Bandaru,S., Nayarisseri,A. and Bidwai,A. An in silico appraisal to identify high affinity anti-apoptotic synthetic tetrapeptide inhibitors targeting the mammalian caspase 3 enzyme Asian Pac J Cancer Prev (2014) 15, 10137-10142. PubMed Europe PubMed DOI I
Khalil,H., Bertrand,M.J.M., Vandenabeele,P. and Widmann,C. Caspase-3 and RasGAP: A stress-sensing survival/demise switch Trends Cell Biol (2014) 24, 83-89. PubMed Europe PubMed DOI
Lee,G.H., Lee,E.J. and Hah,S.S. TAMRA- and Cy5-Labeled Probe for Efficient Kinetic Characterization of Caspase-3 Anal Biochem (2014) 446, 22-24. PubMed Europe PubMed DOI A
Li,B., Blanc,J.M., Sun,Y., Yang,L., Zaorsky,N.G., Giacalone,N.J., Torossian,A. and Lu,B. Assessment of M867, a selective caspase-3 inhibitor, in an orthotopic mouse model for non-small cell lung carcinoma Am J Cancer Res (2014) 4, 161-171. PubMed Europe PubMed PMC EPMC I
Li,Z., Pan,Y., Zhong,W., Zhu,Y., Zhao,Y., Li,L., Liu,W., Zhou,H. and Yang,C. Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors Bioorg Med Chem (2014) 22, 6735-6745. PubMed Europe PubMed DOI I
Ma,J., Zou,C., Guo,L., Seneviratne,D.S., Tan,X., Kwon,Y.K., An,J., Bowser,R., Defrances,M.C. and Zarnegar,R. Novel death defying domain in Met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes Hepatology (2014) 59, 2010-2021. PubMed Europe PubMed DOI
Shen,C., Xiong,W.C. and Mei,L. Caspase-3, shears for synapse pruning Dev Cell (2014) 28, 604-606. PubMed Europe PubMed DOI
Vickers,C.J., Gonzalez-Paez,G.E. and Wolan,D.W. Discovery of a highly selective caspase-3 substrate for imaging live cells ACS Chem Biol (2014) 9, 2199-2203. PubMed Europe PubMed DOI P L
Wang,F., Wang,L., Zhao,Y., Li,Y., Ping,G., Xiao,S., Chen,K., Zhu,W., Gong,P., Yang,J. and Wu,C. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts Mol Oncol (2014) 8, 1640-1652. PubMed Europe PubMed DOI
Wang,J.Y., Chen,F., Fu,X.Q., Ding,C.S., Zhou,L., Zhang,X.H. and Luo,Z.G. Caspase-3 cleavage of Dishevelled induces elimination of postsynaptic structures Dev Cell (2014) 28, 670-684. PubMed Europe PubMed DOI
Wu,L., Lu,M., Yan,Z., Tang,X., Sun,B., Liu,W., Zhou,H. and Yang,C. 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors Bioorg Med Chem (2014) 22, 2416-2426. PubMed Europe PubMed DOI I
Ye,D., Shuhendler,A.J., Cui,L., Tong,L., Tee,S.S., Tikhomirov,G., Felsher,D.W. and Rao,J. Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo Nat Chem (2014) 6, 519-526. PubMed Europe PubMed DOI PMC EPMC L
Ye,D., Shuhendler,A.J., Pandit,P., Brewer,K.D., Tee,S.S., Cui,L., Tikhomirov,G., Rutt,B. and Rao,J. Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis Chem Sci (2014) 4, 3845-3852. PubMed Europe PubMed DOI PMC EPMC L
Yun,N., Lee,Y.M., Kim,C., Shibayama,H., Tanimura,A., Hamanaka,Y., Kanakura,Y., Park,I.S., Jo,A., Shin,J.H., Ju,C., Kim,W.K. and Oh,Y.J. Anamorsin, a novel caspase-3 substrate in neurodegeneration J Biol Chem (2014) 289, 22183-22195. PubMed Europe PubMed DOI P
Zhou,Z., Peng,L., Wang,X., Xiang,Y. and Tong,A. A new colorimetric strategy for monitoring caspase 3 activity by HRP-mimicking DNAzyme-peptide conjugates Analyst (2014) 139, 1178-1183. PubMed Europe PubMed DOI A

2013

Adamova,E., Kleparnik,K. and Matalova,E. Sensitive method of caspase-3 detection in single stem cell Chem Listy (2013) 107, s289-s290. A
Brentnall,M., Rodriguez-Menocal,L., De Guevara,R.L., Cepero,E. and Boise,L.H. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis BMC Cell Biol (2013) 14, 32-32. PubMed Europe PubMed DOI PMC EPMC
Challapalli,A., Kenny,L.M., Hallett,W.A., Kozlowski,K., Tomasi,G., Gudi,M., Al-Nahhas,A., Coombes,R.C. and Aboagye,E.O. 18F-ICMT-11, a caspase-3-specific PET tracer for apoptosis: biodistribution and radiation dosimetry J Nucl Med (2013) 54, 1551-1556. PubMed Europe PubMed DOI L
Chen,Y., Xu,R., Chen,J., Li,X. and He,Q. Cleavage of bleomycin hydrolase by caspase-3 during apoptosis Oncol Rep (2013) 30, 939-944. PubMed Europe PubMed DOI
Fu,Q., Duan,X., Yan,S., Wang,L., Zhou,Y., Jia,S., Du,J., Wang,X., Zhang,Y. and Zhan,L. Bioluminescence imaging of caspase-3 activity in mouse liver Apoptosis (2013) 18, 998-1007. PubMed Europe PubMed DOI L
Galban,S., Jeon,Y.H., Bowman,B.M., Stevenson,J., Sebolt,K.A., Sharkey,L.M., Lafferty,M., Hoff,B.A., Butler,B.L., Wigdal,S.S., Binkowski,B.F., Otto,P., Zimmerman,K., Vidugiris,G., Encell,L.P., Fan,F., Wood,K.V., Galban,C.J., Ross,B.D. and Rehemtulla,A. Imaging proteolytic activity in live cells and animal models PLoS ONE (2013) 8, e66248-e66248. PubMed Europe PubMed DOI PMC EPMC L
Gao,D., Xu,Z., Qiao,P., Liu,S., Zhang,L., He,P., Zhang,X., Wang,Y. and Min,W. Cadmium induces liver cell apoptosis through caspase-3A activation in purse red common carp (Cyprinus carpio) PLoS ONE (2013) 8, e83423-e83423. PubMed Europe PubMed DOI PMC EPMC
Garcia-Faroldi,G., Melo,F.R., Ronnberg,E., Grujic,M. and Pejler,G. Active caspase-3 is stored within secretory compartments of viable mast cells J Immunol (2013) 191, 1445-1452. PubMed Europe PubMed DOI
Iwasaki,T., Katayama,T., Kohama,K., Endo,Y. and Sawasaki,T. Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin phosphatase targeting subunit 1 during apoptosis Mol Biol Cell (2013) 24, 748-756. PubMed Europe PubMed DOI P
Kim,N.N., Lee,J., Habibi,H.R. and Choi,C.Y. Molecular cloning and expression of caspase-3 in the protandrous cinnamon clownfish, Amphiprion melanopus, during sex change Fish Physiol Biochem (2013) 39, 417-429. PubMed Europe PubMed DOI
Krause-Heuer,A.M., Howell,N.R., Matesic,L., Dhand,G., Young,E.L., Burgess,L., Jiang,C.D., Lengkeek,N.A., Fookes,C.J.R., Pham,T.Q., Sobrio,F., Greguric,I. and Fraser,B.H. A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis MedChemComm (2013) 4, 347-352. DOI L I
Limpachayaporn,P., Schafers,M., Schober,O., Kopka,K. and Haufe,G. Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents Bioorg Med Chem (2013) 21, 2025-2036. PubMed Europe PubMed DOI I
Limpachayaporn,P., Riemann,B., Kopka,K., Schober,O., Schafers,M. and Haufe,G. Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7 Eur J Med Chem (2013) 64, 562-578. PubMed Europe PubMed DOI I
Liu,D., Tian,Z., Yan,Z., Wu,L., Ma,Y., Wang,Q., Liu,W., Zhou,H. and Yang,C. Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors Bioorg Med Chem (2013) 21, 2960-2967. PubMed Europe PubMed DOI I
Liu,G.H., Wang,C. and Ding,Z.Y. Overexpression of the truncated form of livin reveals a complex interaction with caspase-3 Int J Oncol (2013) 42, 2037-2045. PubMed Europe PubMed DOI
MacKenzie,S.H. and Clark,A.C. Slow folding and assembly of a procaspase-3 interface variant Biochemistry (2013) 52, 3415-3427. PubMed Europe PubMed DOI
MacKenzie,S.H., Schipper,J.L., England,E.J., Thomas III,M.E., Blackburn,K., Swartz,P. and Clark,A.C. Lengthening the intersubunit linker of procaspase 3 leads to constitutive activation Biochemistry (2013) 52, 6219-6231. PubMed Europe PubMed DOI
Naarmann-de Vries,I.S., Urlaub,H., Ostareck,D.H. and Ostareck-Lederer,A. Caspase-3 cleaves hnRNP K in erythroid differentiation Cell Death Dis (2013) 4, e548-e548. PubMed Europe PubMed DOI P
Schroeder,T., Barandun,J., Flutsch,A., Briand,C., Mittl,P.R. and Grutter,M.G. Specific inhibition of caspase-3 by a competitive DARPin: molecular mimicry between native and designed inhibitors Structure (2013) 21, 277-289. PubMed Europe PubMed DOI S
Sharma,S., Basu,A. and Agrawal,R.K. Pharmacophore modeling and docking studies on some nonpeptide-based caspase-3 inhibitors Biomed Res Int (2013) 2013, 306081-306081. PubMed Europe PubMed DOI PMC EPMC I
Shimizu,K. and Sawasaki,T. Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity FEBS Lett (2013) 587, 2219-2225. PubMed Europe PubMed DOI
Thomsen,N.D., Koerber,J.T. and Wells,J.A. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Proc Natl Acad Sci U S A (2013) 110, 8477-8482. PubMed Europe PubMed DOI S
Vickers,C.J., Gonzalez-Paez,G.E. and Wolan,D.W. Selective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acids ACS Chem Biol (2013) 8, 1558-1566. PubMed Europe PubMed DOI I
Vuojola,J., Syrjanpaa,M., Lamminmaki,U. and Soukka,T. Genetically encoded protease substrate based on lanthanide-binding peptide for time-gated fluorescence detection Anal Chem (2013) 85, 1367-1373. PubMed Europe PubMed DOI A
Witek,M.A. and Fung,L.W. Quantitative studies of caspase-3 catalyzed alphaII-spectrin breakdown Brain Res (2013) 1533, 1-15. PubMed Europe PubMed DOI P
Xia,C.F., Chen,G., Gangadharmath,U., Gomez,L.F., Liang,Q., Mu,F., Mocharla,V.P., Su,H., Szardenings,A.K., Walsh,J.C., Zhao,T. and Kolb,H.C. In vitro and in vivo evaluation of the caspase-3 substrate-based radiotracer [(18)F]-CP18 for PET imaging of apoptosis in tumors Mol Imaging Biol (2013) 15, 748-757. PubMed Europe PubMed DOI L
Yoon,H.K. and Yoo,T.H. A novel protease activity assay method based on an engineered autoinhibited protein using an enzyme-linked immunoassay Analyst (2013) 138, 7164-7168. PubMed Europe PubMed DOI A
Zhang,J., Wang,X., Cui,W., Wang,W., Zhang,H., Liu,L., Zhang,Z., Li,Z., Ying,G., Zhang,N. and Li,B. Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage Nat Commun (2013) 4, 2157-2157. PubMed Europe PubMed DOI L

2012

Chaudhry,P., Singh,M., Parent,S. and Asselin,E. Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation Mol Cell Biol (2012) 32, 826-839. PubMed Europe PubMed DOI
Elvitigala,D.A., Whang,I., Premachandra,H.K., Umasuthan,N., Oh,M.J., Jung,S.J., Yeo,S.Y., Lim,B.S., Lee,J.H., Park,H.C. and Lee,J. Caspase 3 from rock bream (Oplegnathus fasciatus): genomic characterization and transcriptional profiling upon bacterial and viral inductions Fish Shellfish Immunol (2012) 33, 99-110. PubMed Europe PubMed DOI
Firoozpour,L., Sadatnezhad,K., Dehghani,S., Pourbasheer,E., Foroumadi,A., Shafiee,A. and Amanlou,M. An efficient piecewise linear model for predicting activity of caspase-3 inhibitors Daru (2012) 20, 31-31. PubMed Europe PubMed DOI PMC EPMC I
Glantz,Y., Sabag,O., Lichtenstein,M., Grodzovski,I. and Lorberboum-Galski,H. Eliminating the six N-terminal amino acids of the caspase 3 large subunit improved production of a biologically active IL2-caspase3 chimeric protein Biotechnol Prog (2012) 28, 573-580. PubMed Europe PubMed DOI E
Kang,H.J., Lee,Y.M., Jeong,M.S., Kim,M., Bae,K.H., Kim,S.J. and Chung,S.J. Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci Rep (2012) 32, 305-313. PubMed Europe PubMed DOI
Kushida,Y., Hanaoka,K., Komatsu,T., Terai,T., Ueno,T., Yoshida,K., Uchiyama,M. and Nagano,T. Red fluorescent scaffold for highly sensitive protease activity probes Bioorg Med Chem Lett (2012) 22, 3908-3911. PubMed Europe PubMed DOI A
Liu,Y., Hu,Y., Guo,Y., Ma,H., Li,J. and Jiang,C. Targeted imaging of activated caspase-3 in the central nervous system by a dual functional nano-device J Control Release (2012) 163, 203-210. PubMed Europe PubMed DOI L
Miyauchi,K., Urano,E., Takizawa,M., Ichikawa,R. and Komano,J. Therapeutic potential of HIV protease-activable CASP3 Sci Rep (2012) 2, 359-359. PubMed Europe PubMed DOI PMC EPMC U
Nguyen,Q.D., Challapalli,A., Smith,G., Fortt,R. and Aboagye,E.O. Imaging apoptosis with positron emission tomography: 'Bench to bedside' development of the caspase-3/7 specific radiotracer [(18)F]ICMT-11 Eur J Cancer (2012) 48, 432-440. PubMed Europe PubMed DOI L
Pan,Y., Guo,M., Nie,Z., Huang,Y., Peng,Y., Liu,A., Qing,M. and Yao,S. Colorimetric detection of apoptosis based on caspase-3 activity assay using unmodified gold nanoparticles Chem Commun (Camb) (2012) 48, 997-999. PubMed Europe PubMed DOI A
Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G. Human caspases in vitro: expression, purification and kinetic characterization Protein Expr Purif (2012) 84, 236-246. PubMed Europe PubMed DOI E
Samiulla,D.S., Naidu,A., Rao,G.V. and Ramachandra,M. Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3 Org Med Chem Lett (2012) 2, 27-27. PubMed Europe PubMed DOI I
Smith,G.S., Voyer-Grant,J.A. and Harauz,G. Monitoring cleaved caspase-3 activity and apoptosis of immortalized oligodendroglial cells using live-cell imaging and cleaveable fluorogenic-dye substrates following potassium-induced membrane depolarization J Vis Exp (2012) , 3422-3422. PubMed Europe PubMed DOI L
Vanden Berghe,T., Kersse,K. and Vandenabeele,P. Caspase-3 and caspase-7 [ISSN:978-0-12-407743-0] (2012) 3, 2256-2265. DOI
Vuojola,J., Riuttamaki,T., Kulta,E., Arppe,R. and Soukka,T. Fluorescence-quenching-based homogeneous caspase-3 activity assay using photon upconversion Anal Chim Acta (2012) 725, 67-73. PubMed Europe PubMed DOI A I
Walters,J., Schipper,J.L., Swartz,P., Mattos,C. and Clark,A.C. Allosteric modulation of caspase 3 through mutagenesis Biosci Rep (2012) 32, 401-411. PubMed Europe PubMed DOI
Xie,Y., Zhao,R., Tan,Y., Zhang,X., Liu,F., Jiang,Y. and Tan,C. Conjugated polymer-based real-time fluorescence caspase assays ACS Appl Mater Interfaces (2012) 4, 405-410. PubMed Europe PubMed DOI A
Zhu,Q., Gao,L., Chen,Z., Zheng,S., Shu,H., Li,J., Jiang,H. and Liu,S. A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions Eur J Med Chem (2012) 54, 232-238. PubMed Europe PubMed DOI I

2011

Burguillos,M.A., Deierborg,T., Kavanagh,E., Persson,A., Hajji,N., Garcia-Quintanilla,A., Cano,J., Brundin,P., Englund,E., Venero,J.L. and Joseph,B. Caspase signalling controls microglia activation and neurotoxicity Nature (2011) 472, 319-324. PubMed Europe PubMed DOI
Cao,C.Y., Chen,Y., Wu,F.Z., Deng,Y. and Liang,G.L. Caspase-3 controlled assembly of nanoparticles for fluorescence turn on Chem Commun (Camb) (2011) 47, 10320-10322. PubMed Europe PubMed DOI
Ganesan,R., Jelakovic,S., Mittl,P.R., Caflisch,A. and Grutter,M.G. In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 67, 842-850. PubMed Europe PubMed DOI PMC EPMC S I
Gao,Y.Y., Liu,B.Q., Niu,X.F., Zhuang,Y. and Wang,H.Q. Caspase-dependent cleavage of BAG3 associated with pancreatic cancer cell apoptosis Chin J Cancer Prev Treat (2011) 18, 81-84. I
Gloria,P.M., Coutinho,I., Goncalves,L.M., Baptista,C., Soares,J., Newton,A.S., Moreira,R., Saraiva,L. and Santos,M.M. Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway Eur J Med Chem (2011) 46, 2141-2146. PubMed Europe PubMed DOI I
Hornle,M., Peters,N., Thayaparasingham,B., Vorsmann,H., Kashkar,H. and Kulms,D. Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis Oncogene (2011) 30, 575-587. PubMed Europe PubMed DOI
Jiang,Y. and Hansen,T.V. Isatin 1,2,3-triazoles as potent inhibitors against caspase-3 Bioorg Med Chem Lett (2011) 21, 1626-1629. PubMed Europe PubMed DOI I
Li,M., Ding,Y., Mu,Y., Ao,J. and Chen,X. Molecular cloning and characterization of caspase-3 in large yellow croaker (Pseudosciaena crocea) Fish Shellfish Immunol (2011) 30, 910-916. PubMed Europe PubMed DOI
Liu,M.C., Kobeissy,F., Zheng,W., Zhang,Z., Hayes,R.L. and Wang,K.K. Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions ASN Neuro (2011) 3, e00051-e00051. PubMed Europe PubMed DOI PMC EPMC P I
Scabini,M., Stellari,F., Cappella,P., Rizzitano,S., Texido,G. and Pesenti,E. In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation Apoptosis (2011) 16, 198-207. PubMed Europe PubMed DOI L
Schipper,J.L., MacKenzie,S.H., Sharma,A. and Clark,A.C. A bifunctional allosteric site in the dimer interface of procaspase-3 Biophys Chem (2011) 159, 100-109. PubMed Europe PubMed DOI
Sengupta,S., Rao,G.V. and Dubey,P.K. Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors Indian J Chem Sect B Org Med Chem (2011) 50, 901-905. I
Sengupta,S., Rao,G.V. and Dubey,P.K. Synthesis and evaluation of indole aspartyl ketones as novel caspase-3 inhibitors Asian J Chem (2011) 23, 5517-5520. I
Solier,S. and Pommier,Y. MDC1 cleavage by caspase-3: a novel mechanism for inactivating the DNA damage response during apoptosis Cancer Res (2011) 71, 906-913. PubMed Europe PubMed DOI
Vaishnav,M., MacFarlane,M. and Dickens,M. Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis Exp Cell Res (2011) 317, 1028-1039. PubMed Europe PubMed DOI P
Vegran,F., Boidot,R., Solary,E. and Lizard-Nacol,S. A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly PLoS ONE (2011) 6, e29058-e29058. PubMed Europe PubMed DOI PMC EPMC R
Walters,J., Swartz,P., Mattos,C. and Clark,A.C. Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3 Arch Biochem Biophys (2011) 508, 31-38. PubMed Europe PubMed DOI
Wong,W. Neuroscience: Memory-stealing caspase Sci Signal (2011) 4, ec2- DOI
Wu,Y., Wang,D., Wang,X., Wang,Y., Ren,F., Chang,D., Chang,Z. and Jia,B. Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells Cell Physiol Biochem (2011) 27, 539-546. PubMed Europe PubMed DOI
Yang,B., Hosgood,S.A. and Nicholson,M.L. Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys Transplantation (2011) 91, 501-507. PubMed Europe PubMed DOI
Yang,B., Elias,J.E., Bloxham,M. and Nicholson,M.L. Synthetic small interfering RNA down-regulates caspase-3 and affects apoptosis, IL-1 beta, and viability of porcine proximal tubular cells J Cell Biochem (2011) 112, 1337-1347. PubMed Europe PubMed DOI K
Yates,D. Synaptic plasticity: finely tuning caspase function Nat Rev Neurosci (2011) 12, 371-371. PubMed Europe PubMed DOI
Zorn,J.A., Wille,H., Wolan,D.W. and Wells,J.A. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation J Am Chem Soc (2011) 133, 19630-19633. PubMed Europe PubMed DOI

2010

Chopra,M., Das,P. and Sharma,A.C. Caspase-3 knock-down reverses contractile dysfunction induced by sepsis in adult rat ventricular myocytes Br J Pharmacol (2010) 160, 93-100. PubMed Europe PubMed DOI K
D'Amelio,M., Cavallucci,V. and Cecconi,F. Neuronal caspase-3 signaling: not only cell death Cell Death Differ (2010) 17, 1104-1114. PubMed Europe PubMed DOI
Gray,D.C., Mahrus,S. and Wells,J.A. Activation of specific apoptotic caspases with an engineered small-molecule-activated protease Cell (2010) 142, 637-646. PubMed Europe PubMed DOI
Larsen,B.D., Rampalli,S., Burns,L.E., Brunette,S., Dilworth,F.J. and Megeney,L.A. Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks Proc Natl Acad Sci U S A (2010) 107, 4230-4235. PubMed Europe PubMed DOI PMC EPMC
Luo,M., Lu,Z., Sun,H., Yuan,K., Zhang,Q., Meng,S., Wang,F., Guo,H., Ju,X., Liu,Y., Ye,T., Lu,Z. and Zhai,Z. Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity Cell Res (2010) 20, 211-222. PubMed Europe PubMed DOI
Murphy,D.J., Walker,B., Ryan,C.A. and Martin,S.L. The inhibitor profiling of the caspase family of proteases using substrate-derived peptide glyoxals Biochem Biophys Res Commun (2010) 402, 483-488. PubMed Europe PubMed DOI I
Newton,A.S., Gloria,P.M., Goncalves,L.M., Dos Santos,D.J., Moreira,R., Guedes,R.C. and Santos,M.M. Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study Eur J Med Chem (2010) 45, 3858-3863. PubMed Europe PubMed DOI I
Parker,A., Hardisty-Hughes,R.E., Wisby,L., Joyce,S. and Brown,S.D. Melody, an ENU mutation in caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice Mamm Genome (2010) 21, 565-576. PubMed Europe PubMed DOI M
Peterson,Q.P., Hsu,D.C., Novotny,C.J., West,D.C., Kim,D., Schmit,J.M., Dirikolu,L., Hergenrother,P.J. and Fan,T.M. Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound Cancer Res (2010) 70, 7232-7241. PubMed Europe PubMed DOI
Sirbulescu,R.F. and Zupanc,G.K. Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system Neuroscience (2010) 171, 599-612. PubMed Europe PubMed DOI
Wang,X.H., Zhang,L., Mitch,W.E., Ledoux,J.M., Hu,J. and Du,J. Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity J Biol Chem (2010) 285, 21249-21257. PubMed Europe PubMed DOI P
Yakovlev,A., Khafizova,M., Abdullaev,Z., Loukinov,D. and Kondratyev,A. Epigenetic regulation of caspase-3 gene expression in rat brain development Gene (2010) 450, 103-108. PubMed Europe PubMed DOI K

2009

Agniswamy,J., Fang,B. and Weber,I.T. Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7 Apoptosis (2009) 14, 1135-1144. PubMed Europe PubMed DOI S
Alves,J., Wurdak,H., Garay-Malpartida,H.M., Harris,J.L., Occhiucci,J.M., Belizario,J.E. and Li,J. TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7 Biochem Biophys Res Commun (2009) 384, 495-500. PubMed Europe PubMed DOI P
Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V. Evaluation of recombinant caspase specificity by competitive substrates Anal Biochem (2009) 394, 68-74. PubMed Europe PubMed DOI A P
Boeneman,K., Mei,B.C., Dennis,A.M., Bao,G., Deschamps,J.R., Mattoussi,H. and Medintz,I.L. Sensing caspase 3 activity with quantum dot-fluorescent protein assemblies J Am Chem Soc (2009) 131, 3828-3829. PubMed Europe PubMed DOI PMC EPMC A
Chen,N., Huang,Y., Yang,L., Liu,R. and Yang,J.J. Designing caspase-3 sensors for imaging of apoptosis in living cells Chemistry (2009) 15, 9311-9314. PubMed Europe PubMed DOI
Chen,S.S., Cao,F., Gao,F., Xu,A.J., Tian,X.B., Xiao,X.P., Yang,S.B. and Tian,Y.K. [Construction of rat constitutively active recombinant caspase-3 and investigation of its pro-apoptotic effect in vitro] Zhonghua Yi Xue Za Zhi (2009) 89, 3074-3078. PubMed Europe PubMed E
Chen,S.S., Cao,F., Gao,F., Xu,A.J., Tian,X.B., Xiao,X.P., Yang,S.B. and Tian,Y.K. Construction of rat constitutively active recombinant caspase-3 and investigation of its pro-apoptotic effect in vitro Zhonghua Yi Xue Za Zhi (2009) 89, 3074-3078. DOI
Demon,D., Van Damme,P., Vanden Berghe,T., Deceuninck,A., Van Durme,J., Verspurten,J., Helsens,K., Impens,F., Wejda,M., Schymkowitz,J., Rousseau,F., Madder,A., Vandekerckhove,J., Declercq,W., Gevaert,K. and Vandenabeele,P. Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity Mol Cell Proteomics (2009) 8, 2700-2714. PubMed Europe PubMed DOI P
Fang,B., Fu,G., Agniswamy,J., Harrison,R.W. and Weber,I.T. Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling Apoptosis (2009) 14, 741-752. PubMed Europe PubMed DOI P S I
Guzman,J.R., Fukuda,S. and Pelus,L.M. Inhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2 Gene Ther Mol Biol (2009) 13B, 264-273. PubMed Europe PubMed
Havran,L.M., Chong,D.C., Childers,W.E., Dollings,P.J., Dietrich,A., Harrison,B.L., Marathias,V., Tawa,G., Aulabaugh,A., Cowling,R., Kapoor,B., Xu,W., Mosyak,L., Moy,F., Hum,W.T., Wood,A. and Robichaud,A.J. 3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3 Bioorg Med Chem (2009) 17, 7755-7768. PubMed Europe PubMed DOI I
Herrera-Mendez,C.H., Becila,S., Blanchet,X., Pelissier,P., Delourme,D., Coulis,G., Sentandreu,M.A., Boudjellal,A., Bremaud,L. and Ouali,A. Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3 FEBS Lett (2009) 583, 2743-2748. PubMed Europe PubMed DOI
Janicke,R.U. MCF-7 breast carcinoma cells do not express caspase-3 Breast Cancer Res Treat (2009) 117, 219-221. PubMed Europe PubMed DOI
Kihara,T., Nakamura,C., Suzuki,M., Han,S.W., Fukazawa,K., Ishihara,K. and Miyake,J. Development of a method to evaluate caspase-3 activity in a single cell using a nanoneedle and a fluorescent probe Biosens Bioelectron (2009) 25, 22-27. PubMed Europe PubMed DOI A
Kim,H.Y., Kim,G.Y., Kim,S.S., Nam,M.K. and Rhim,H. Establishment of the expression system for studying the function of active caspase-3 in zebrafish Mol Biol Rep (2009) 36, 405-413. PubMed Europe PubMed DOI
Lee,H., Akers,W.J., Cheney,P.P., Edwards,W.B., Liang,K., Culver,J.P. and Achilefu,S. Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe J Biomed Opt (2009) 14, 040507-040507. PubMed Europe PubMed DOI L
Lozanov,V., Ivanov,I.P., Benkova,B. and Mitev,V. Peptide substrate for caspase-3 with 2-aminoacridone as reporting group Amino Acids (2009) 36, 581-586. PubMed Europe PubMed DOI A
Milam,S.L. and Clark,A.C. Folding and assembly kinetics of procaspase-3 Protein Sci (2009) 18, 2500-2517. PubMed Europe PubMed DOI
Park,K., Yi,S.Y., Kim,U.L., Lee,C.S., Chung,J.W., Chung,S.J. and Kim,M. Monitoring of cleavage preference for caspase-3 using recombinant protein substrates J Microbiol Biotechnol (2009) 19, 911-917. PubMed Europe PubMed DOI
Peterson,Q.P., Goode,D.R., West,D.C., Ramsey,K.N., Lee,J.J. and Hergenrother,P.J. PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition J Mol Biol (2009) 388, 144-158. PubMed Europe PubMed DOI PMC EPMC
Podichetty,A.K., Faust,A., Kopka,K., Wagner,S., Schober,O., Schafers,M. and Haufe,G. Fluorinated isatin derivatives. Part 1: Synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors Bioorg Med Chem (2009) 17, 2680-2688. PubMed Europe PubMed DOI I
Schmidt,M.F., El-Dahshan,A., Keller,S. and Rademann,J. Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor Angew Chem Int Ed Engl (2009) 48, 6346-6349. PubMed Europe PubMed DOI I
Schulz,R., Reszka,P. and Bednarski,P.J. Selectivity of new caspase 3 and 8 tetrapeptide substrates can be explained by automated docking analysis Chem Cent J (2009) 3, 76-76. DOI
Timmer,J.C., Zhu,W., Pop,C., Regan,T., Snipas,S.J., Eroshkin,A.M., Riedl,S.J. and Salvesen,G.S. Structural and kinetic determinants of protease substrates Nat Struct Mol Biol (2009) 16, 1101-1108. PubMed Europe PubMed DOI P
Walters,J., Pop,C., Scott,F.L., Drag,M., Swartz,P., Mattos,C., Salvesen,G.S. and Clark,A.C. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis Biochem J (2009) 424, 335-345. PubMed Europe PubMed DOI S
Wang,Q., Mach,R.H. and Reichert,D.E. Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors J Chem Inf Model (2009) 49, 1963-1973. PubMed Europe PubMed DOI PMC EPMC I
Wolan,D.W., Zorn,J.A., Gray,D.C. and Wells,J.A. Small-molecule activators of a proenzyme Science (2009) 326, 853-858. PubMed Europe PubMed DOI

2008

Abdul-Ghani,M. and Megeney,L.A. Rehabilitation of a contract killer: caspase-3 directs stem cell differentiation Cell Stem Cell (2008) 2, 515-516. PubMed Europe PubMed DOI
Akdemir,O., Berksoy,I., Karaoclan,A., Barut,S., Bilguvar,K., Cirakoclu,B., Sahan,E. and Colak,A. Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury J Clin Neurosci (2008) 15, 672-678. PubMed Europe PubMed DOI I
Cen,H., Mao,F., Aronchik,I., Fuentes,R.J. and Firestone,G.L. DEVD-NucView488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells FASEB J (2008) 22, 2243-2252. PubMed Europe PubMed DOI L
Colantonio,P., Leboffe,L., Bolli,A., Marino,M., Ascenzi,P. and Luisi,G. Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation Biochem Biophys Res Commun (2008) 377, 757-762. PubMed Europe PubMed DOI I
Du,J.Q., Wu,J., Zhang,H.J., Zhang,Y.H., Qiu,B.Y., Wu,F., Chen,Y.H., Li,J.Y., Nan,F.J., Ding,J.P. and Li,J. Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species J Biol Chem (2008) 283, 30205-30215. PubMed Europe PubMed DOI PMC EPMC I
Fu,G., Chumanevich,A.A., Agniswamy,J., Fang,B., Harrison,R.W. and Weber,I.T. Structural basis for executioner caspase recognition of P5 position in substrates Apoptosis (2008) 13, 1291-1302. PubMed Europe PubMed DOI P
Huang,H.S. and Lee,E.Y. Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response J Biol Chem (2008) 283, 18135-18146. PubMed Europe PubMed DOI PMC EPMC
Jang,J.S., Kim,K.M., Choi,J.E., Cha,S.I., Kim,C.H., Lee,W.K., Kam,S., Jung,T.H. and Park,J.Y. Identification of polymorphisms in the caspase-3 gene and their association with lung cancer risk Mol Carcinog (2008) 47, 383-390. PubMed Europe PubMed DOI M
Janzen,V., Fleming,H.E., Riedt,T., Karlsson,G., Riese,M.J., Lo Celso,C., Reynolds,G., Milne,C.D., Paige,C.J., Karlsson,S., Woo,M. and Scadden,D.T. Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3 Cell Stem Cell (2008) 2, 584-594. PubMed Europe PubMed DOI
Kang,H.J., Lee,Y.M., Jeong,Y.J., Park,K., Jang,M., Park,S.G., Bae,K.H., Kim,M. and Chung,S.J. Large-scale preparation of active caspase-3 in E. coli by designing its thrombin-activatable precursors BMC Biotechnol (2008) 8, 92-92. PubMed Europe PubMed DOI PMC EPMC E
Kim,K.W., Moretti,L. and Lu,B. M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models PLoS ONE (2008) 3, e2275-e2275. PubMed Europe PubMed DOI PMC EPMC I
McStay,G.P., Salvesen,G.S. and Green,D.R. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways Cell Death Differ (2008) 15, 322-331. PubMed Europe PubMed DOI P
Pereira,N.A. and Song,Z. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity Biochem Biophys Res Commun (2008) 377, 873-877. PubMed Europe PubMed DOI P I
Sakai,J., Yoshimori,A., Nose,Y., Mizoroki,A., Okita,N., Takasawa,R. and Tanuma,S. Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3 Bioorg Med Chem (2008) 16, 4854-4859. PubMed Europe PubMed DOI I
Sharma,S., Sahu,K., Jain,P., Mourya,V.K. and Agrawal,R.K. QSAR study of 1,3-dioxo-4-methyl-2,3-dihydro-1h-pyrrolo[3,4-c]quinolines as caspase-3 inhibitors Med Chem Res (2008) 17, 399-411. DOI I
Tao,Y., Zafar,I., Kim,J., Schrier,R.W. and Edelstein,C.L. Caspase-3 gene deletion prolongs survival in polycystic kidney disease J Am Soc Nephrol (2008) 19, 749-755. PubMed Europe PubMed DOI PMC EPMC
Valanne,A., Malmi,P., Appelblom,H., Niemela,P. and Soukka,T. A dual-step fluorescence resonance energy transfer-based quenching assay for screening of caspase-3 inhibitors Anal Biochem (2008) 375, 71-81. PubMed Europe PubMed DOI A
Vazquez,J., Garcia-Jareno,A., Mondragon,L., Rubio-Martinez,J., Perez-Paya,E. and Albericio,F. Conformationally restricted hydantoin-based peptidomimetics as inhibitors of caspase-3 with basic groups allowed at the S3 enzyme subsite ChemMedChem (2008) 3, 979-985. PubMed Europe PubMed DOI I
Walsh,J.G., Cullen,S.P., Sheridan,C., Luthi,A.U., Gerner,C. and Martin,S.J. Executioner caspase-3 and caspase-7 are functionally distinct proteases Proc Natl Acad Sci U S A (2008) 105, 12815-12819. PubMed Europe PubMed DOI PMC EPMC
Wright,M.H., Farquhar,M.J., Aletrari,M.O., Ladds,G. and Hodgkin,M.N. Identification of caspase 3 motifs and critical aspartate residues in human phospholipase D1b and phospholipase D2a Biochem Biophys Res Commun (2008) 369, 478-484. PubMed Europe PubMed DOI P
Yamashita,M., Mizusawa,N., Hojo,M. and Yabu,T. Extensive apoptosis and abnormal morphogenesis in pro-caspase-3 transgenic zebrafish during development J Exp Biol (2008) 211, 1874-1881. PubMed Europe PubMed DOI

2007

Aulabaugh,A., Kapoor,B., Huang,X., Dollings,P., Hum,W.T., Banker,A., Wood,A. and Ellestad,G. Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry Biochemistry (2007) 46, 9462-9471. PubMed Europe PubMed DOI T I
Auziol,C., Mechali,M. and Maiorano,D. Geminin is cleaved by caspase-3 during apoptosis in Xenopus egg extracts Biochem Biophys Res Commun (2007) 361, 276-280. PubMed Europe PubMed DOI
Chu,W., Rothfuss,J., d'Avignon,A., Zeng,C., Zhou,D., Hotchkiss,R.S. and Mach,R.H. Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors J Med Chem (2007) 50, 3751-3755. PubMed Europe PubMed DOI I
Denault,J.B., Eckelman,B.P., Shin,H., Pop,C. and Salvesen,G.S. Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9 Biochem J (2007) 405, 11-19. PubMed Europe PubMed DOI
Denault,J.B., Drag,M., Salvesen,G.S., Alves,J., Heidt,A.B., Deveraux,Q. and Harris,J.L. Small molecules not direct activators of caspases Nat Chem Biol (2007) 3, 519-520. PubMed Europe PubMed DOI
Halle,M., Liu,Y.C., Hardy,S., Theberge,J.F., Blanchetot,C., Bourdeau,A., Meng,T.C. and Tremblay,M.L. Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response Mol Cell Biol (2007) 27, 1172-1190. PubMed Europe PubMed DOI PMC EPMC
Jahani-Asl,A., Basak,A. and Tsang,B.K. Caspase-3-mediated cleavage of Akt: involvement of non-consensus sites and influence of phosphorylation FEBS Lett (2007) 581, 2883-2888. PubMed Europe PubMed DOI P
Ju,W., Valencia,C.A., Pang,H., Ke,Y., Gao,W., Dong,B. and Liu,R. Proteome-wide identification of family member-specific natural substrate repertoire of caspases Proc Natl Acad Sci U S A (2007) 104, 14294-14299. PubMed Europe PubMed DOI PMC EPMC P
Kuzelova,K., Grebenova,D. and Hrkal,Z. Labeling of apoptotic JURL-MK1 cells by fluorescent caspase-3 inhibitor FAM-DEVD-fmk occurs mainly at site(s) different from caspase-3 active site Cytometry A (2007) 71, 605-611. PubMed Europe PubMed DOI L I
Li,X., Fan,R., Zou,X., Gao,L., Jin,H., Du,R., Xia,L. and Fan,D. Inhibitory effect of recombinant adenovirus carrying immunocaspase-3 on hepatocellular carcinoma Biochem Biophys Res Commun (2007) 358, 489-494. PubMed Europe PubMed DOI
Matsuda,N., Takano,Y., Kageyama,S., Hatakeyama,N., Shakunaga,K., Kitajima,I., Yamazaki,M. and Hattori,Y. Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock Cardiovasc Res (2007) 76, 132-140. PubMed Europe PubMed DOI
Song,Y., Shen,K. and He,C.X. [Construction of autocatalytic caspase-3 driven by amplified human telomerase reverse transcriptase promoter and its enhanced efficacy of inducing apoptosis in human ovarian carcinoma] Zhonghua Fu Chan Ke Za Zhi (2007) 42, 617-622. PubMed Europe PubMed U
Song,Y. and Shen,K. [Construction of autocatalytic caspase-3 and its effects of inducing apoptosis in human ovarian carcinoma] Zhonghua Fu Chan Ke Za Zhi (2007) 42, 846-851. PubMed Europe PubMed
Suzuki,Y., Ohkubo,N., Aoto,M., Maeda,N., Cicha,I., Miki,T. and Mitsuda,N. Participation of caspase-3-like protease in oxidation-induced impairment of erythrocyte membrane properties Biorheology (2007) 44, 179-190. PubMed Europe PubMed
Valencia,C.A., Bailey,C. and Liu,R. Novel zebrafish caspase-3 substrates Biochem Biophys Res Commun (2007) 361, 311-316. PubMed Europe PubMed DOI P
Wong,C.K., Chen,Z., So,K.L., Li,D. and Li,P. Polycomb group protein RING1B is a direct substrate of caspases-3 and -9 Biochim Biophys Acta (2007) 1773, 844-852. PubMed Europe PubMed DOI P
Yoshimori,A., Sakai,J., Sunaga,S., Kobayashi,T., Takahashi,S., Okita,N., Takasawa,R. and Tanuma,S. Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO BMC Pharmacol (2007) 7, 8-8. PubMed Europe PubMed DOI PMC EPMC I

2006

Boston-Howes,W., Gibb,S.L., Williams,E.O., Pasinelli,P., Brown,R.H., Jr. and Trotti,D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2 J Biol Chem (2006) 281, 14076-14084. PubMed Europe PubMed DOI
[YEAR:3-5-2006]Boulware,K.T. and Daugherty,P.S. Protease specificity determination by using cellular libraries of peptide substrates (CLiPS) Proc Natl Acad Sci U S A (3-5-2006) 103, 7583-7588. PubMed Europe PubMed DOI PMC EPMC P
Chakraborty,C., Nandi,S.S., Sinha,S. and Gera,V.K. Zebrafish caspase-3: molecular cloning, characterization, crystallization and phylogenetic analysis Protein Pept Lett (2006) 13, 633-640. PubMed Europe PubMed
Chakraborty,C., Saha,G., Sarkar,B., Pal,S., Chatterjee,T.K. and Sadhu,A.K. Caspase-3 induced apoptosis in transgenic zebrafish Biotechnol Lett (2006) 28, 189-196. PubMed Europe PubMed DOI
[YEAR:9-3-2006]Chen,Y.H., Zhang,Y.H., Zhang,H.J., Liu,D.Z., Gu,M., Li,J.Y., Wu,F., Zhu,X.Z., Li,J. and Nan,F.J. Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors J Med Chem (9-3-2006) 49, 1613-1623. PubMed Europe PubMed DOI I
[YEAR:21-9-2006]Ekici,O.D., Li,Z.Z., Campbell,A.J., James,K.E., Asgian,J.L., Mikolajczyk,J., Salvesen,G.S., Ganesan,R., Jelakovic,S., Grutter,M.G. and Powers,J.C. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10 J Med Chem (21-9-2006) 49, 5728-5749. PubMed Europe PubMed DOI I
Fang,B., Boross,P.I., Tozser,J. and Weber,I.T. Structural and kinetic analysis of caspase-3 reveals role for S5 binding site in substrate recognition J Mol Biol (2006) 360, 654-666. PubMed Europe PubMed DOI P S
Feeney,B., Pop,C., Swartz,P., Mattos,C. and Clark,A.C. Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3 Biochemistry (2006) 45, 13249-13263. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-8-2006]Ganesan,R., Jelakovic,S., Campbell,A.J., Li,Z.Z., Asgian,J.L., Powers,J.C. and Grutter,M.G. Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors Biochemistry (1-8-2006) 45, 9059-9067. PubMed Europe PubMed DOI S I
Ganesan,R., Mittl,P.R., Jelakovic,S. and Grutter,M.G. Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis J Mol Biol (2006) 359, 1378-1388. PubMed Europe PubMed DOI S
Giaime,E., Sunyach,C., Herrant,M., Grosso,S., Auberger,P., McLean,P.J., Checler,F. and da Costa,C.A. Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway J Biol Chem (2006) 281, 11515-11522. PubMed Europe PubMed DOI
[YEAR:21-12-2006]Huesmann,G.R. and Clayton,D.F. Dynamic role of postsynaptic caspase-3 and BIRC4 in Zebra finch song-response habituation Neuron (21-12-2006) 52, 1061-1072. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-11-2006]Kanthasamy,A.G., Anantharam,V., Zhang,D., Latchoumycandane,C., Jin,H., Kaul,S. and Kanthasamy,A. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models Free Radic Biol Med (15-11-2006) 41, 1578-1589. PubMed Europe PubMed DOI P I
[YEAR:16-11-2006]Kopka,K., Faust,A., Keul,P., Wagner,S., Breyholz,H.J., Holtke,C., Schober,O., Schafers,M. and Levkau,B. 5-Pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis J Med Chem (16-11-2006) 49, 6704-6715. PubMed Europe PubMed DOI I
Kravchenko,D.V., Kuzovkova,J.A., Kysil,V.M., Tkachenko,S.E., Malarchuk,S., Okun,I.M. and Ivachtchenko,A.V. Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors: synthesis and SAR of 8-sulfamoyl-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4c]quinolines Lett Drug Des Discov (2006) 3, 61-70. I
[YEAR:10-2-2006]Lakhani,S.A., Masud,A., Kuida,K., Porter,G.A., Jr., Booth,C.J., Mehal,W.Z., Inayat,I. and Flavell,R.A. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis Science (10-2-2006) 311, 847-851. PubMed Europe PubMed DOI K
Menard,I., Gervais,F.G., Nicholson,D.W. and Roy,S. Caspase-3 cleaves the formin-homology-domain-containing protein FHOD1 during apoptosis to generate a C-terminal fragment that is targeted to the nucleolus Apoptosis (2006) 11, 1863-1876. PubMed Europe PubMed DOI
[YEAR:21-11-2006]Mitchell,D.A., Morton,S.U. and Marletta,M.A. Design and characterization of an active site selective caspase-3 transnitrosating agent ACS Chem Biol (21-11-2006) 1, 659-665. PubMed Europe PubMed DOI I
Oomman,S., Strahlendorf,H., Dertien,J. and Strahlendorf,J. Bergmann glia utilize active caspase-3 for differentiation Brain Res (2006) 1078, 19-34. PubMed Europe PubMed DOI
Porter,A.G. Flipping the safety catch of procaspase-3 Nat Chem Biol (2006) 2, 509-510. PubMed Europe PubMed DOI
[YEAR:27-8-2006]Putt,K.S., Chen,G.W., Pearson,J.M., Sandhorst,J.S., Hoagland,M.S., Kwon,J.T., Hwang,S.K., Jin,H., Churchwell,M.I., Cho,M.H., Doerge,D.R., Helferich,W.G. and Hergenrother,P.J. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy Nat Chem Biol (27-8-2006) 2, 543-550. PubMed Europe PubMed DOI
[YEAR:11-4-2006]Salako,M.A., Carter,M.J. and Kass,G.E. Coxsackievirus protein 2BC blocks host cell apoptosis by inhibiting caspase-3 J Biol Chem (11-4-2006) 281, 16296-16304. PubMed Europe PubMed DOI
[YEAR:14-4-2006]Sun,W., Kimura,H., Hattori,N., Tanaka,S., Matsuyama,S. and Shiota,K. Proliferation related acidic leucine-rich protein PAL31 functions as a caspase-3 inhibitor Biochem Biophys Res Commun (14-4-2006) 342, 817-823. PubMed Europe PubMed DOI
[YEAR:13-9-2006]Szymczyk,K.H., Freeman,T.A., Adams,C.S., Srinivas,V. and Steinbeck,M.J. Active caspase-3 is required for osteoclast differentiation J Cell Physiol (13-9-2006) 209, 836-844. PubMed Europe PubMed DOI
Wu,W., Misra,R.S., Russell,J.Q., Flavell,R.A., Rincon,M. and Budd,R.C. Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3 J Biol Chem (2006) 281, 10682-10690. PubMed Europe PubMed DOI
[YEAR:8-5-2006]Wu,X., Simone,J., Hewgill,D., Siegel,R., Lipsky,P.E. and He,L. Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe Cytometry A (8-5-2006) 69, 477-486. PubMed Europe PubMed DOI I
[YEAR:21-4-2006]Yin,Q., Park,H.H., Chung,J.Y., Lin,S.C., Lo,Y.C., da Graca,L.S., Jiang,X. and Wu,H. Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine Mol Cell (21-4-2006) 22, 259-268. PubMed Europe PubMed DOI
Zhang,X.T., Song,T.B., Li,D.M. and Wu,X.L. [Caspase-3 antisense oligodeoxynucleotides inhibit caspase-3 expression and apoptosis of gamma-irradiated HL-60 cells] Fen Zi Xi Bao Sheng Wu Xue Bao (2006) 39, 304-312. PubMed Europe PubMed
[YEAR:4-8-2006]Zhou,D., Chu,W., Rothfuss,J., Zeng,C., Xu,J., Jones,L., Welch,M.J. and Mach,R.H. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis Bioorg Med Chem Lett (4-8-2006) 16, 5041-5046. PubMed Europe PubMed DOI I

2005

Balsam,L.B., Kofidis,T. and Robbins,R.C. Caspase-3 inhibition preserves myocardial geometry and long-term function after infarction J Surg Res (2005) 124, 194-200. PubMed Europe PubMed DOI I
[YEAR:1-12-2005]Chu,W., Zhang,J., Zeng,C., Rothfuss,J., Tu,Z., Chu,Y., Reichert,D.E., Welch,M.J. and Mach,R.H. N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies J Med Chem (1-12-2005) 48, 7637-7647. PubMed Europe PubMed DOI I
[YEAR:3-10-2005]Feeney,B. and Clark,A.C. Reassembly of active caspase-3 is facilitated by the propeptide J Biol Chem (3-10-2005) 280, 39772-39785. PubMed Europe PubMed DOI
[YEAR:4-8-2005]Goode,D.R., Sharma,A.K. and Hergenrother,P.J. Using peptidic inhibitors to systematically probe the S1' site of caspase-3 and caspase-7 Org Lett (4-8-2005) 7, 3529-3532. PubMed Europe PubMed DOI I
[YEAR:15-2-2005]Han,Y., Giroux,A., Colucci,J., Bayly,C.I., McKay,D.J., Roy,S., Xanthoudakis,S., Vaillancourt,J., Rasper,D.M., Tam,J., Tawa,P., Nicholson,D.W. and Zamboni,R.J. Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors Bioorg Med Chem Lett (15-2-2005) 15, 1173-1180. PubMed Europe PubMed DOI I
[YEAR:2-9-2005]Karki,P., Lee,J., Shin,S.Y., Cho,B. and Park,I.S. Kinetic comparison of procaspase-3 and caspase-3 Arch Biochem Biophys (2-9-2005) 442, 125-132. PubMed Europe PubMed DOI
[YEAR:1-4-2005]Kravchenko,D.V., Kysil,V.V., Ilyn,A.P., Tkachenko,S.E., Maliarchouk,S., Okun,I.M. and Ivachtchenko,A.V. 1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors Bioorg Med Chem Lett (1-4-2005) 15, 1841-1845. PubMed Europe PubMed DOI I
[YEAR:2-6-2005]Kravchenko,D.V., Kuzovkova,Y.A., Kysil,V.M., Tkachenko,S.E., Maliarchouk,S., Okun,I.M., Balakin,K.V. and Ivachtchenko,A.V. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3- diones as potent caspase-3 inhibitors J Med Chem (2-6-2005) 48, 3680-3683. PubMed Europe PubMed DOI I
[YEAR:14-9-2005]Kravchenko,D.V., Kysil,V.M., Tkachenko,S.E., Maliarchouk,S., Okun,I.M. and Ivachtchenko,A.V. Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones Eur J Med Chem (14-9-2005) 40, 1377-1383. PubMed Europe PubMed DOI I
[YEAR:16-6-2005]Lo,S.S., Lo,S.H. and Lo,S.H. Cleavage of cten by caspase-3 during apoptosis Oncogene (16-6-2005) 24, 4311-4314. PubMed Europe PubMed DOI
[YEAR:12-7-2005]Mellon,C., Aspiotis,R., Black,C.W., Bayly,C.I., Grimm,E.L., Giroux,A., Han,Y., Isabel,E., McKay,D.J., Nicholson,D.W., Rasper,D.M., Roy,S., Tam,J., Thornberry,N.A., Vaillancourt,J.P., Xanthoudakis,S. and Zamboni,R. Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors Bioorg Med Chem Lett (12-7-2005) 15, 3886-3890. PubMed Europe PubMed DOI I
Mitchell,D.A. and Marletta,M.A. Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine Nat Chem Biol (2005) 1, 154-158. PubMed Europe PubMed DOI
O'Brien,M.A., Daily,W.J., Hesselberth,P.E., Moravec,R.A., Scurria,M.A., Klaubert,D.H., Bulleit,R.F. and Wood,K.V. Homogeneous, bioluminescent protease assays: caspase-3 as a model J Biomol Screen (2005) 10, 137-148. PubMed Europe PubMed DOI A
[YEAR:12-10-2005]Oomman,S., Strahlendorf,H., Finckbone,V. and Strahlendorf,J. Non-lethal active caspase-3 expression in Bergmann glia of postnatal rat cerebellum Brain Res Dev Brain Res (12-10-2005) 160, 130-145. PubMed Europe PubMed DOI
[YEAR:25-4-2005]Pelletier,M., Oliver,L., Meflah,K. and Vallette,F.M. Caspase-3 can be pseudo-activated by a Ca2+-dependent proteolysis at a non-canonical site FEBS Lett (25-4-2005) 579, 2364-2368. PubMed Europe PubMed DOI
Petrassi,H.M., Williams,J.A., Li,J., Tumanut,C., Ek,J., Nakai,T., Masick,B., Backes,B.J. and Harris,J.L. A strategy to profile prime and non-prime proteolytic substrate specificity Bioorg Med Chem Lett (2005) 15, 3162-3166. PubMed Europe PubMed DOI P
[YEAR:7-5-2005]Stucki,J.W. and Simon,H.U. Mathematical modeling of the regulation of caspase-3 activation and degradation J Theor Biol (7-5-2005) 234, 123-131. PubMed Europe PubMed DOI
[YEAR:2-5-2005]Wang,Z.Q., Liao,J. and Diwu,Z. N-DEVD-N'-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay Bioorg Med Chem Lett (2-5-2005) 15, 2335-2338. PubMed Europe PubMed DOI A

2004

[YEAR:15-2-2004]Aouad,S.M., Cohen,L.Y., Sharif-Askari,E., Haddad,E.K., Alam,A. and Sekaly,R.P. Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death J Immunol (15-2-2004) 172, 2316-2323. PubMed Europe PubMed
[YEAR:6-5-2004]Becker,J.W., Rotonda,J., Soisson,S.M., Aspiotis,R., Bayly,C., Francoeur,S., Gallant,M., Garcia-Calvo,M., Giroux,A., Grimm,E., Han,Y., McKay,D., Nicholson,D.W., Peterson,E., Renaud,J., Roy,S., Thornberry,N. and Zamboni,R. Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis J Med Chem (6-5-2004) 47, 2466-2474. PubMed Europe PubMed DOI I
[YEAR:15-4-2004]Chen,F., Arseven,O.K. and Cryns,V.L. Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis J Biol Chem (15-4-2004) 279, 27542-27548. PubMed Europe PubMed DOI P
Cronin,D., Daly,C., O'Doherty,T., Heenan,M., Scanlon,K.J. and Clynes,M. Construction and transfection of a ribozyme targeting human caspase-3 Anticancer Res (2004) 24, 425-431. PubMed Europe PubMed
DeBiasi,R.L., Robinson,B.A., Sherry,B., Bouchard,R., Brown,R.D., Rizeq,M., Long,C. and Tyler,K.L. Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo J Virol (2004) 78, 11040-11050. PubMed Europe PubMed DOI PMC EPMC I
Du,J., Wang,X., Miereles,C., Bailey,J.L., Debigare,R., Zheng,B., Price,S.R. and Mitch,W.E. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions J Clin Invest (2004) 113, 115-123. PubMed Europe PubMed DOI PMC EPMC
[YEAR:25-11-2004]Endo,M., Nakayama,K., Kaida,Y. and Majima,T. Design and synthesis of photochemically controllable caspase-3 Angew Chem Int Ed Engl (25-11-2004) 43, 5643-5645. PubMed Europe PubMed DOI
[YEAR:16-8-2004]Feeney,B., Pop,C., Tripathy,A. and Clark,A.C. Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3 Biochem J (16-8-2004) 384, 515-525. PubMed Europe PubMed DOI PMC EPMC
[YEAR:24-8-2004]Hardy,J.A., Lam,J., Nguyen,J.T., O'Brien,T. and Wells,J.A. Discovery of an allosteric site in the caspases Proc Natl Acad Sci U S A (24-8-2004) 101, 12461-12466. PubMed Europe PubMed DOI PMC EPMC
[YEAR:21-5-2004]Kerr,L.E., McGregor,A.L., Amet,L.E., Asada,T., Spratt,C., Allsopp,T.E., Harmar,A.J., Shen,S., Carlson,G., Logan,N., Kelly,J.S. and Sharkey,J. Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia Cell Death Differ (21-5-2004) 11, 1102-1111. PubMed Europe PubMed DOI
Kerr,L.E., Birse-Archbold,J.L., Simon,A., Logan,N., Scott,F., Carlson,G., Nicholson,D.W., Kelly,J.S. and Sharkey,J. Differential regulation of caspase-3 by pharmacological and developmental stimuli as demonstrated using humanised caspase-3 mice Apoptosis (2004) 9, 739-747. PubMed Europe PubMed DOI K
[YEAR:16-12-2004]Micale,N., Vairagoundar,R., Yakovlev,A.G. and Kozikowski,A.P. Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3 J Med Chem (16-12-2004) 47, 6455-6458. PubMed Europe PubMed DOI I
Miura,M., Chen,X.D., Allen,M.R., Bi,Y., Gronthos,S., Seo,B.M., Lakhani,S., Flavell,R.A., Feng,X.H., Robey,P.G., Young,M. and Shi,S. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells J Clin Invest (2004) 114, 1704-1713. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:15-11-2004]Mueller,T.H., Kienle,K., Beham,A., Geissler,E.K., Jauch,K.W. and Rentsch,M. Caspase 3 inhibition improves survival and reduces early graft injury after ischemia and reperfusion in rat liver transplantation Transplantation (15-11-2004) 78, 1267-1273. PubMed Europe PubMed DOI
Nicholson,D. and Thornberry,N.A. Caspase-3 and caspase-7 [ISSN:0-12-079610-4] (2004) 2, 1298-1302. V
[YEAR:1-7-2004]Park,I.S., Moon,H.R., Seok,H. and Lee,M. Rearrangement of tryptophan residues in caspase-3 active site upon activation Biochim Biophys Acta (1-7-2004) 1700, 5-9. PubMed Europe PubMed DOI
Paroni,G., Mizzau,M., Henderson,C., del Sal,G., Schneider,C. and Brancolini,C. Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis Mol Biol Cell (2004) 15, 2804-2818. PubMed Europe PubMed DOI PMC EPMC P
[YEAR:26-3-2004]Pelletier,M., Cartron,P.F., Delaval,F., Meflah,K., Vallette,F.M. and Oliver,L. Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit Biochem Biophys Res Commun (26-3-2004) 316, 93-99. PubMed Europe PubMed DOI
[YEAR:30-4-2004]Wu,Y.H., Shih,S.F. and Lin,J.Y. Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3 J Biol Chem (30-4-2004) 279, 19264-19275. PubMed Europe PubMed DOI

2003

[YEAR:28-10-2003]Bose,K., Pop,C., Feeney,B. and Clark,A.C. An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3 Biochemistry (28-10-2003) 42, 12298-12310. PubMed Europe PubMed DOI
Chen,L., Smith,L., Wang,Z. and Smith,J.B. Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination Mol Pharmacol (2003) 64, 334-345. PubMed Europe PubMed DOI
Erlanson,D.A., Lam,J.W., Wiesmann,C., Luong,T.N., Simmons,R.L., DeLano,W.L., Choong,I.C., Burdett,M.T., Flanagan,W.M., Lee,D., Gordon,E.M. and O'Brien,T. In situ assembly of enzyme inhibitors using extended tethering Nat Biotechnol (2003) 21, 308-314. PubMed Europe PubMed DOI I
Gianinazzi,C., Grandgirard,D., Imboden,H., Egger,L., Meli,D.N., Bifrare,Y.D., Joss,P.C., Tauber,M.G., Borner,C. and Leib,S.L. Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis Acta Neuropathol (Berl) (2003) 105, 499-507. PubMed Europe PubMed DOI I
Isabel,E., Black,W.C., Bayly,C.I., Grimm,E.L., Janes,M.K., McKay,D.J., Nicholson,D.W., Rasper,D.M., Renaud,J., Roy,S., Tam,J., Thornberry,N.A., Vaillancourt,J.P., Xanthoudakis,S. and Zamboni,R. Nicotinyl aspartyl ketones as inhibitors of caspase-3 Bioorg Med Chem Lett (2003) 13, 2137-2140. PubMed Europe PubMed DOI I
[YEAR:28-3-2003]Kook,S., Kim,D.H., Shim,S.R., Kim,W., Chun,J.S. and Song,W.K. Caspase-dependent cleavage of tensin induces disruption of actin cytoskeleton during apoptosis Biochem Biophys Res Commun (28-3-2003) 303, 37-45. PubMed Europe PubMed DOI P
[YEAR:5-6-2003]McKay,T.R., Bell,S., Tenev,T., Stoll,V., Lopes,R., Lemoine,N.R. and McNeish,I.A. Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy Oncogene (5-6-2003) 22, 3539-3547. PubMed Europe PubMed DOI
Ni,C.Z., Li,C., Wu,J.C., Spada,A.P. and Ely,K.R. Conformational restrictions in the active site of unliganded human caspase-3 J Mol Recognit (2003) 16, 121-124. PubMed Europe PubMed DOI S
[YEAR:28-10-2003]Pop,C., Feeney,B., Tripathy,A. and Clark,A.C. Mutations in the procaspase-3 dimer interface affect the activity of the zymogen Biochemistry (28-10-2003) 42, 12311-12320. PubMed Europe PubMed DOI
[YEAR:1-8-2003]Sulpizi,M., Laio,A., VandeVondele,J., Cattaneo,A., Rothlisberger,U. and Carloni,P. Reaction mechanism of caspases: insights from QM/MM Car-Parrinello simulations Proteins (1-8-2003) 52, 212-224. PubMed Europe PubMed DOI
Sulpizi,M., Rothlisberger,U. and Carloni,P. Molecular dynamics studies of caspase-3 Biophys J (2003) 84, 2207-2215. PubMed Europe PubMed DOI PMC EPMC
Woo,M., Hakem,R., Furlonger,C., Hakem,A., Duncan,G.S., Sasaki,T., Bouchard,D., Lu,L., Wu,G.E., Paige,C.J. and Mak,T.W. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity Nat Immunol (2003) 4, 1016-1022. PubMed Europe PubMed DOI

2002

[YEAR:1-3-2002]Anantharam,V., Kitazawa,M., Wagner,J., Kaul,S. and Kanthasamy,A.G. Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl J Neurosci (1-3-2002) 22, 1738-1751. PubMed Europe PubMed I
Back,S.H., Shin,S. and Jang,S.K. Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis J Biol Chem (2002) 277, 27200-27209. PubMed Europe PubMed DOI
[YEAR:5-12-2002]Chapman,J.G., Magee,W.P., Stukenbrok,H.A., Beckius,G.E., Milici,A.J. and Tracey,W.R. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury Eur J Pharmacol (5-12-2002) 456, 59-68. PubMed Europe PubMed DOI I
[YEAR:7-11-2002]Choong,I.C., Lew,W., Lee,D., Pham,P., Burdett,M.T., Lam,J.W., Wiesmann,C., Luong,T.N., Fahr,B., DeLano,W.L., McDowell,R.S., Allen,D.A., Erlanson,D.A., Gordon,E.M. and O'Brien,T. Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design J Med Chem (7-11-2002) 45, 5005-5022. PubMed Europe PubMed DOI I
[YEAR:29-7-2002]Kyoung,M., Kim,S.Y., Seok,H.Y., Park,I.S. and Lee,M. Probing the caspase-3 active site by fluorescence lifetime measurements Biochim Biophys Acta (29-7-2002) 1598, 74-79. PubMed Europe PubMed
[YEAR:8-3-2002]Liu,W., Wang,G. and Yakovlev,A.G. Identification and functional analysis of the rat caspase-3 gene promoter J Biol Chem (8-3-2002) 277, 8273-8278. PubMed Europe PubMed DOI
McCollum,A.T., Nasr,P. and Estus,S. Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death J Neurochem (2002) 82, 1208-1220. PubMed Europe PubMed DOI I
Pelizon,C., d'Adda di Fagagna,F., Farrace,L. and Laskey,R.A. Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis EMBO Rep (2002) 3, 780-784. PubMed Europe PubMed DOI PMC EPMC
Zeng,L. and Smith,L.D. Caspase-3 colorimetric assay Biotechniques (2002) 33, 1196-1197. PubMed Europe PubMed A
[YEAR:8-8-2002]Zhan,Q., Jin,S., Ng,B., Plisket,J., Shangary,S., Rathi,A., Brown,K.D. and Baskaran,R. Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis Oncogene (8-8-2002) 21, 5335-5345. PubMed Europe PubMed DOI

2001

[YEAR:26-1-2001]Affar,E.B., Germain,M., Winstall,E., Vodenicharov,M., Shah,R.G., Salvesen,G.S. and Poirier,G.G. Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis J Biol Chem (26-1-2001) 276, 2935-2942. PubMed Europe PubMed DOI I
[YEAR:3-4-2001]Barkett,M., Dooher,J.E., Lemonnier,L., Simmons,L., Scarpati,J.N., Wang,Y. and Gilmore,T.D. Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3 Biochim Biophys Acta (3-4-2001) 1526, 25-36. PubMed Europe PubMed DOI
[YEAR:1-3-2001]Bratton,S.B., Walker,G., Srinivasula,S.M., Sun,X.M., Butterworth,M., Alnemri,E.S. and Cohen,G.M. Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes EMBO J (1-3-2001) 20, 998-1009. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-6-2001]Choi,E.K., Zaidi,N.F., Miller,J.S., Crowley,A.C., Merriam,D.E., Lilliehook,C., Buxbaum,J.D. and Wasco,W. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2 J Biol Chem (1-6-2001) 276, 19197-19204. PubMed Europe PubMed DOI
Deckwerth,T.L., Adams,L.M., Wiessner,C., Allegrini,P.R., Rudin,M., Sauter,A., Hengerer,B., Sayers,R.O., Rovelli,G., Aja,T., May,R., Nalley,K., Linton,S., Karanewsky,D.S., Wu,J.C., Roggo,S., Schmitz,A., Contreras,P.C. and Tomaselli,K.J. Long-term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors Drug Dev Res (2001) 52, 579-586. I
Fujita,E., Egashira,J., Urase,K., Kuida,K. and Momoi,T. Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo Cell Death Differ (2001) 8, 335-344. PubMed Europe PubMed DOI
Jiang,D.M., Jha,N., Boonplueang,R. and Andersen,J.K. Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells J Neurochem (2001) 76, 1745-1755. PubMed Europe PubMed DOI
Kang,K.H., Lee,K.H., Kim,M.Y. and Choi,K.H. Caspase-3-mediated cleavage of the NF-kappa B subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis J Biol Chem (2001) 276, 24638-24644. PubMed Europe PubMed DOI
[YEAR:7-6-2001]Lee,D., Long,S.A., Murray,J.H., Adams,J.L., Nuttall,M.E., Nadeau,D.P., Kikly,K., Winkler,J.D., Sung,C.M., Ryan,M.D., Levy,M.A., Keller,P.M. and DeWolf,W.E., Jr. Potent and selective nonpeptide inhibitors of caspases 3 and 7 J Med Chem (7-6-2001) 44, 2015-2026. PubMed Europe PubMed DOI I
[YEAR:1-6-2001]Lee,K.K., Ohyama,T., Yajima,N., Tsubuki,S. and Yonehara,S. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation J Biol Chem (1-6-2001) 276, 19276-19285. PubMed Europe PubMed DOI
[YEAR:10-6-2001]Li,D.W.C., Xiang,H., Mao,Y.W., Wang,J., Fass,U., Zhang,X.Y. and Xu,C. Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis Exp Cell Res (10-6-2001) 266, 279-291. PubMed Europe PubMed DOI
[YEAR:10-6-2001]Marini,M., Frabetti,F., Canaider,S., Dini,L., Falcieri,E. and Poirier,G.G. Modulation of caspase-3 activity by zinc ions and by the cell redox state Exp Cell Res (10-6-2001) 266, 323-332. PubMed Europe PubMed DOI
Matikainen,T., Perez,G.I., Zheng,T.S., Kluzak,T.R., Rueda,B.R., Flavell,R.A. and Tilly,J.L. Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary Endocrinology (2001) 142, 2468-2480. PubMed Europe PubMed DOI
[YEAR:1-6-2001]Morishita,H., Makishima,T., Kaneko,C., Lee,Y.S., Segil,N., Takahashi,K., Kuraoka,A., Nakagawa,T., Nabekura,J., Nakayama,K. and Nakayama,K.I. Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice Biochem Biophys Res Commun (1-6-2001) 284, 142-149. PubMed Europe PubMed DOI
Muneta,Y., Shimoji,Y. and Mori,Y. Porcine caspase-3: Its cloning and activity during apoptosis of PK15 cells induced by porcine Fas ligand J Interferon Cytokine Res (2001) 21, 409-415. PubMed Europe PubMed DOI
[YEAR:12-1-2001]Myohanen,S. and Baylin,S.B. Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter J Biol Chem (12-1-2001) 276, 1634-1642. PubMed Europe PubMed DOI
[YEAR:1-7-2001]Oppenheim,R.W., Flavell,R.A., Vinsant,S., Prevette,D., Kuan,C.Y. and Rakic,P. Programmed cell death of developing mammalian neurons after genetic deletion of caspases J Neurosci (1-7-2001) 21, 4752-4760. PubMed Europe PubMed
[YEAR:27-11-2001]Pop,C., Chen,Y.R., Smith,B., Bose,K., Bobay,B., Tripathy,A., Franzen,S. and Clark,A.C. Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer Biochemistry (27-11-2001) 40, 14224-14235. PubMed Europe PubMed DOI
Rank,K.B., Mildner,A.M., Leone,J.W., Koeplinger,K.A., Chou,K.C., Tomasselli,A.G., Heinrikson,R.L. and Sharma,S.K. [W206R]-procaspase 3: An inactivatable substrate for caspase 8 Protein Expr Purif (2001) 22, 258-266. PubMed Europe PubMed DOI
[YEAR:9-3-2001]Riedl,S.J., Renatus,M., Schwarzenbacher,R., Zhou,Q., Sun,C., Fesik,S.W., Liddington,R.C. and Salvesen,G.S. Structural basis for the inhibition of caspase-3 by XIAP Cell (9-3-2001) 104, 791-800. PubMed Europe PubMed S
[YEAR:22-5-2001]Roy,S., Bayly,C.I., Gareau,Y., Houtzager,V.M., Kargman,S., Keen,S.L., Rowland,K., Seiden,I.M., Thornberry,N.A. and Nicholson,D.W. Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide Proc Natl Acad Sci U S A (22-5-2001) 98, 6132-6137. PubMed Europe PubMed DOI PMC EPMC
Ruetten,H., Badorff,C., Ihling,C., Zeiher,A.M. and Dimmeler,S. Inhibition of caspase-3 improves contractile recovery of stunned myocardium, independent of apoptosis-inhibitory effects J Am Coll Cardiol (2001) 38, 2063-2070. PubMed Europe PubMed DOI
Sandri,M., El Meslemani,A.H., Sandri,C., Schjerling,P., Vissing,K., Andersen,J.L., Rossini,K., Carraro,U. and Angelini,C. Caspase 3 expression correlates with skeletal muscle apoptosis in Duchenne and facioscapulo human muscular dystrophy. A potential target for pharmacological treatment? J Neuropathol Exp Neurol (2001) 60, 302-312. PubMed Europe PubMed
Schrantz,N., Auffredou,M.T., Bourgeade,M.F., Besnault,L., Leca,G. and Vazquez,A. Zinc-mediated regulation of caspases activity: dose-dependent inhibition or activation of caspase-3 in the human Burkitt lymphoma B cells (Ramos) Cell Death Differ (2001) 8, 152-161. PubMed Europe PubMed DOI
[YEAR:20-4-2001]Shearwin-Whyatt,L., Baliga,B., Doumanis,J. and Kumar,S. Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells Biochem Biophys Res Commun (20-4-2001) 282, 1114-1119. PubMed Europe PubMed DOI
[YEAR:15-6-2001]Silke,J., Ekert,P.G., Day,C.L., Hawkins,C.J., Baca,M., Chew,J., Pakusch,M., Verhagen,A.M. and Vaux,D.L. Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP EMBO J (15-6-2001) 20, 3114-3123. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-9-2001]Simpson,M.T., MacLaurin,J.G., Xu,D., Ferguson,K.L., Vanderluit,J.L., Davoli,M.A., Roy,S., Nicholson,D.W., Robertson,G.S., Park,D.S. and Slack,R.S. Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice J Neurosci (15-9-2001) 21, 7089-7098. PubMed Europe PubMed
[YEAR:16-3-2001]Takahashi,K., Kamiya,K., Urase,K., Suga,M., Takizawa,T., Mori,H., Yoshikawa,Y., Ichimura,K., Kuida,K. and Momoi,T. Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss Brain Res (16-3-2001) 894, 359-367. PubMed Europe PubMed DOI K
[YEAR:15-11-2001]Yabu,T., Kishi,S., Okazaki,T. and Yamashita,M. Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo Biochem J (15-11-2001) 360, 39-47. PubMed Europe PubMed DOI PMC EPMC
[YEAR:14-9-2001]Yin,X., Gu,S. and Jiang,J.X. The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II-mediated phosphorylation J Biol Chem (14-9-2001) 276, 34567-34572. PubMed Europe PubMed DOI

2000

Bushell,M., Poncet,D., Marissen,W.E., Flotow,H., Lloyd,R.E., Clemens,M.J. and Morley,S.J. Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage Cell Death Differ (2000) 7, 628-636. PubMed Europe PubMed DOI
[YEAR:1-1-2000]Eldadah,B.A., Ren,R.F. and Faden,A.I. Ribozyme-mediated inhibition of caspase-3 protects cerebellar granule cells from apoptosis induced by serum-potassium deprivation J Neurosci (1-1-2000) 20, 179-186. PubMed Europe PubMed K
Flygare,J., Hellgren,D. and Wennborg,A. Caspase-3 mediated cleavage of HsRad51 at an unconventional site Eur J Biochem (2000) 267, 5977-5982. PubMed Europe PubMed DOI
[YEAR:8-9-2000]Huston,E., Beard,M., McCallum,F., Pyne,N.J., Vandenabeele,P., Scotland,G. and Houslay,M.D. The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution J Biol Chem (8-9-2000) 275, 28063-28074. PubMed Europe PubMed DOI
[YEAR:26-12-2000]Krebs,J.F., Srinivasan,A., Wong,A.M., Tomaselli,K.J., Fritz,L.C. and Wu,J.C. Heavy membrane-associated caspase 3: identification, isolation, and characterization Biochemistry (26-12-2000) 39, 16056-16063. PubMed Europe PubMed DOI
[YEAR:26-5-2000]Lee,D., Long,S.A., Adams,J.L., Chan,G., Vaidya,K.S., Francis,T.A., Kikly,K., Winkler,J.D., Sung,C.M., Debouck,C., Richardson,S., Levy,M.A., DeWolf,W.E., Jr., Keller,P.M., Tomaszek,T., Head,M.S., Ryan,M.D., Haltiwanger,R.C., Liang,P.H., Janson,C.A., McDevitt,P.J., Johanson,K., Concha,N.O., Chan,W., Abdel-Meguid,S.S., Badger,A.M., Lark,M.W., Nadeau,D.P., Suva,L.J., Gowen,M. and Nuttall,M.E. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality J Biol Chem (26-5-2000) 275, 16007-16014. PubMed Europe PubMed DOI S I
[YEAR:1-11-2000]Liu,W. and Linn,S. Proteolysis of the human DNA polymerase epsilon catalytic subunit by caspase-3 and calpain specifically during apoptosis Nucleic Acids Res (1-11-2000) 28, 4180-4188. PubMed Europe PubMed PMC EPMC
Liu,X. and Wang,X. In vitro assays for caspase-3 activation and DNA fragmentation Methods Enzymol (2000) 322, 177-182. PubMed Europe PubMed A V
[YEAR:31-3-2000]Marissen,W.E., Guo,Y., Thomas,A.A., Matts,R.L. and Lloyd,R.E. Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis J Biol Chem (31-3-2000) 275, 9314-9323. PubMed Europe PubMed DOI I
Meergans,T., Hildebrandt,A.K., Horak,D., Haenisch,C. and Wendel,A. The short prodomain influences caspase-3 activation in HeLa cells Biochem J (2000) 349, 135-140. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-7-2000]Mukerjee,N., McGinnis,K.M., Park,Y.H., Gnegy,M.E. and Wang,K.K. Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells Arch Biochem Biophys (15-7-2000) 379, 337-343. PubMed Europe PubMed DOI
[YEAR:12-10-2000]Nicholson,D.W. From bench to clinic with apoptosis-based therapeutic agents Nature (12-10-2000) 407, 810-816. PubMed Europe PubMed DOI
[YEAR:15-8-2000]Saunders,P.A., Cooper,J.A., Roodell,M.M., Schroeder,D.A., Borchert,C.J., Isaacson,A.L., Schendel,M.J., Godfrey,K.G., Cahill,D.R., Walz,A.M., Loegering,R.T., Gaylord,H., Woyno,I.J., Kaluyzhny,A.E., Krzyzek,R.A., Mortari,F., Tsang,M. and Roff,C.F. Quantification of active caspase 3 in apoptotic cells Anal Biochem (15-8-2000) 284, 114-124. PubMed Europe PubMed DOI
[YEAR:26-5-2000]Steinhusen,U., Badock,V., Bauer,A., Behrens,J., Wittman-Liebold,B., Dorken,B. and Bommert,K. Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential J Biol Chem (26-5-2000) 275, 16345-16353. PubMed Europe PubMed DOI
[YEAR:1-9-2000]Stennicke,H.R., Renatus,M., Meldal,M. and Salvesen,G.S. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8 Biochem J (1-9-2000) 350, 563-568. PubMed Europe PubMed DOI PMC EPMC A P
Wellington,C.L., Leavitt,B.R. and Hayden,M.R. Huntington disease: new insights on the role of huntingtin cleavage J Neural Transm Suppl (2000) 2000, 1-17. PubMed Europe PubMed P
Wellington,C.L., Singaraja,R., Ellerby,L., Savill,J., Roy,S., Leavitt,B., Cattaneo,E., Hackam,A., Sharp,A., Thornberry,N., Nicholson,D.W., Bredesen,D.E. and Hayden,M.R. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells J Biol Chem (2000) 275, 19831-19838. PubMed Europe PubMed DOI
Zheng,T.S., Hunot,S., Kuida,K., Momoi,T., Srinivasan,A., Nicholson,D.W., Lazebnik,Y. and Flavell,R.A. Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation Nat Med (2000) 6, 1241-1247. PubMed Europe PubMed DOI

1999

Bajusz,S., Fauszt,I., Nemeth,K., Barabas,E., Juhasz,A., Patthy,M. and Bauer,P.I. Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases Biopolymers (1999) 51, 109-118. PubMed Europe PubMed DOI I
[YEAR:1-10-1999]Deveraux,Q.L., Leo,E., Stennicke,H.R., Welsh,K., Salvesen,G.S. and Reed,J.C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases EMBO J (1-10-1999) 18, 5242-5251. PubMed Europe PubMed DOI PMC EPMC
Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A. Purification and catalytic properties of human caspase family members Cell Death Differ (1999) 6, 362-369. PubMed Europe PubMed DOI
[YEAR:1-4-1999]Gastman,B.R., Johnson,D.E., Whiteside,T.L. and Rabinowich,H. Caspase-mediated degradation of T-cell receptor zeta-chain Cancer Res (1-4-1999) 59, 1422-1427. PubMed Europe PubMed
[YEAR:15-11-1999]Liu,J., Bhalgat,M., Zhang,C., Diwu,Z., Hoyland,B. and Klaubert,D.H. Fluorescent molecular probes V: A sensitive caspase-3 substrate for fluorometric assays Bioorg Med Chem Lett (15-11-1999) 9, 3231-3236. PubMed Europe PubMed A
[YEAR:9-9-1999]Sahara,S., Aoto,M., Eguchi,Y., Imamoto,N., Yoneda,Y. and Tsujimoto,Y. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation Nature (9-9-1999) 401, 168-173. PubMed Europe PubMed DOI
[YEAR:15-8-1999]Satoh,S., Hijikata,M., Handa,H. and Shimotohno,K. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha Biochem J (15-8-1999) 342, 65-70. PubMed Europe PubMed DOI PMC EPMC
Sgorbissa,A., Benetti,R., Marzinotto,S., Schneider,C. and Brancolini,C. Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis J Cell Sci (1999) 112, 4475-4482. PubMed Europe PubMed
Swanton,E., Bishop,N. and Woodman,P. Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis J Biol Chem (1999) 274, 37583-37590. PubMed Europe PubMed DOI

1998

[YEAR:9-10-1998]Colussi,P.A., Harvey,N.L., Shearwin-Whyatt,L.M. and Kumar,S. Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain J Biol Chem (9-10-1998) 273, 26566-26570. PubMed Europe PubMed DOI
Jones,B., Roberts,P.J., Faubion,W.A., Kominami,E. and Gores,G.J. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line Am J Physiol (1998) 275, G723-G730. PubMed Europe PubMed
[YEAR:23-3-1998]Mancini,M., Nicholson,D.W., Roy,S., Thornberry,N.A., Peterson,E.P., Casciola-Rosen,L.A. and Rosen,A. The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling J Cell Biol (23-3-1998) 140, 1485-1495. PubMed Europe PubMed DOI PMC EPMC
[YEAR:7-8-1998]McGinnis,K.M., Whitton,M.M., Gnegy,M.E. and Wang,K.K. Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis J Biol Chem (7-8-1998) 273, 19993-20000. PubMed Europe PubMed DOI
Park,J.A., Kim,K.W., Kim,S.I. and Lee,S.K. Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells Eur J Biochem (1998) 257, 242-248. PubMed Europe PubMed DOI P
[YEAR:18-12-1998]Yang,X., Stennicke,H.R., Wang,B., Green,D.R., Janicke,R.U., Srinivasan,A., Seth,P., Salvesen,G.S. and Froelich,C.J. Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7 J Biol Chem (18-12-1998) 273, 34278-34283. PubMed Europe PubMed DOI
[YEAR:9-1-1998]Zhang,Y., Center,D.M., Wu,D.M., Cruikshank,W.W., Yuan,J., Andrews,D.W. and Kornfeld,H. Processing and activation of pro-interleukin-16 by caspase-3 J Biol Chem (9-1-1998) 273, 1144-1149. PubMed Europe PubMed DOI

1997

Akita,K., Ohtsuki,T., Nukada,Y., Tanimoto,T., Namba,M., Okura,T., Takakura-Yamamoto,R., Torigoe,K., Gu,Y., Su,M.S., Fujii,M., Satoh-Itoh,M., Yamamoto,K., Kohno,K., Ikeda,M. and Kurimoto,M. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells J Biol Chem (1997) 272, 26595-26603. PubMed Europe PubMed DOI I
Alnemri,E.S. Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases J Cell Biochem (1997) 64, 33-42. PubMed Europe PubMed DOI V
[YEAR:21-11-1997]Barkett,M., Xue,D., Horvitz,H.R. and Gilmore,T.D. Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro J Biol Chem (21-11-1997) 272, 29419-29422. PubMed Europe PubMed DOI
[YEAR:2-5-1997]Beyaert,R., Kidd,V.J., Cornelis,S., Van de Craen,M., Denecker,G., Lahti,J.M., Gururajan,R., Vandenabeele,P. and Fiers,W. Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor J Biol Chem (2-5-1997) 272, 11694-11697. PubMed Europe PubMed DOI
[YEAR:21-11-1997]Cryns,V.L., Byun,Y., Rana,A., Mellor,H., Lustig,K.D., Ghanem,L., Parker,P.J., Kirschner,M.W. and Yuan,J. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy J Biol Chem (21-11-1997) 272, 29449-29453. PubMed Europe PubMed DOI
Han,Z., Hendrickson,E.A., Bremner,T.A. and Wyche,J.H. A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro J Biol Chem (1997) 272, 13432-13436. PubMed Europe PubMed DOI I
[YEAR:18-4-1997]Liu,X., Zou,H., Slaughter,C. and Wang,X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis Cell (18-4-1997) 89, 175-184. PubMed Europe PubMed
[YEAR:7-3-1997]Mittl,P.R., Di Marco,S., Krebs,J.F., Bai,X., Karanewsky,D.S., Priestle,J.P., Tomaselli,K.J. and Grutter,M.G. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone J Biol Chem (7-3-1997) 272, 6539-6547. PubMed Europe PubMed DOI S I
[YEAR:3-11-1997]Rheaume,E., Cohen,L.Y., Uhlmann,F., Lazure,C., Alam,A., Hurwitz,J., Sekaly,R.P. and Denis,F. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis EMBO J (3-11-1997) 16, 6346-6354. PubMed Europe PubMed DOI PMC EPMC
[YEAR:10-10-1997]Stennicke,H.R. and Salvesen,G.S. Biochemical characteristics of caspases-3, -6, -7, and -8 J Biol Chem (10-10-1997) 272, 25719-25723. PubMed Europe PubMed DOI
Sun,J., Bottomley,S.P., Kumar,S. and Bird,P.I. Recombinant caspase-3 expressed in Pichia pastoris is fully activated and kinetically indistinguishable from the native enzyme Biochem Biophys Res Commun (1997) 238, 920-924. PubMed Europe PubMed DOI I
[YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W. Substrate specificities of caspase family proteases J Biol Chem (11-4-1997) 272, 9677-9682. PubMed Europe PubMed DOI P
[YEAR:18-7-1997]Thornberry,N.A., Rano,T.A., Peterson,E.P., Rasper,D.M., Timkey,T., Garcia-Calvo,M., Houtzager,V.M., Nordstrom,P.A., Roy,S., Vaillancourt,J.P., Chapman,K.T. and Nicholson,D.W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis J Biol Chem (18-7-1997) 272, 17907-17911. PubMed Europe PubMed DOI P
Van de Craen,M., Vandenabeele,P., Declercq,W., van den Brande,I., Van Loo,G., Molemans,F., Schotte,P., van Criekinge,W., Beyaert,R. and Fiers,W. Characterization of seven murine caspase family members FEBS Lett (1997) 403, 61-69. PubMed Europe PubMed DOI
[YEAR:7-11-1997]Vito,P., Ghayur,T. and D'Adamio,L. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage J Biol Chem (7-11-1997) 272, 28315-28320. PubMed Europe PubMed DOI
Zou,H., Henzel,W.J., Liu,X., Lutschg,A. and Wang,X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 Cell (1997) 90, 405-413. PubMed Europe PubMed DOI

1996

Bullrich,F., Fernandes-Alnemri,T., Litwack,G., Alnemri,E.S. and Croce,C.M. Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3 Genomics (1996) 36, 362-365. PubMed Europe PubMed DOI
[YEAR:1-5-1996]Casciola-Rosen,L., Nicholson,D.W., Chong,T., Rowan,K.R., Thornberry,N.A., Miller,D.K. and Rosen,A. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death J Exp Med (1-5-1996) 183, 1957-1964. PubMed Europe PubMed DOI PMC EPMC
Fernandes-Alnemri,T., Armstrong,R.C., Krebs,J., Srinivasula,S.M., Wang,L., Bullrich,F., Fritz,L.C., Trapani,J.A., Tomaselli,K.J., Litwack,G. and Alnemri,E.S. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains Proc Natl Acad Sci U S A (1996) 93, 7464-7469. PubMed Europe PubMed DOI PMC EPMC I
Juan,T.S., McNiece,I.K., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Fletcher,F.A. Molecular characterization of mouse and rat CPP32beta gene encoding a cysteine protease resembling interleukin-1beta converting enzyme and CED-3 Oncogene (1996) 13, 749-755. PubMed Europe PubMed
[YEAR:28-11-1996]Kuida,K., Zheng,T.S., Na,S., Kuan,C., Yang,D., Karasuyama,H., Rakic,P. and Flavell,R.A. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice Nature (28-11-1996) 384, 368-372. PubMed Europe PubMed DOI K
Martin,S.J., Amarante-Mendes,G.P., Shi,L., Chuang,T.H., Casiano,C.A., O'Brien,G.A., Fitzgerald,P., Tan,E.M., Bokoch,G.M., Greenberg,A.H. and Green,D.R. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease,CPP32, via a novel two- step mechanism EMBO J (1996) 15, 2407-2416. PubMed Europe PubMed PMC EPMC
Quan,L.T., Tewari,M., O'Rourke,K., Dixit,V., Snipas,S.J., Poirier,G.G., Ray,C., Pickup,D.J. and Salvesen,G.S. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B Proc Natl Acad Sci U S A (1996) 93, 1972-1976. PubMed Europe PubMed PMC EPMC
Rotonda,J., Nicholson,D.W., Fazil,K.M., Gallant,M., Gareau,Y., Labelle,M., Peterson,E.P., Rasper,D.M., Ruel,R., Vaillancourt,J.P., Thornberry,N.A. and Becker,J.W. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis Nat Struct Biol (1996) 3, 619-625. PubMed Europe PubMed DOI S I
[YEAR:26-1-1996]Schlegel,J., Peters,I., Orrenius,S., Miller,D.K., Thornberry,N.A., Yamin,T.T. and Nicholson,D.W. CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis J Biol Chem (26-1-1996) 271, 1841-1844. PubMed Europe PubMed DOI I

1995

Nicholson,D.W., Ali,A., Thornberry,N.A., Vaillancourt,J.P., Ding,C.K., Gallant,M., Gareau,Y., Griffin,P.R., Labelle,M., Lazebnik,Y.A., Munday,N.A., Raju,S.M., Smulson,M.E., Yamin,T.T., Yu,V.L. and Miller,D.K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis Nature (1995) 376, 37-43. PubMed Europe PubMed DOI I
Tewari,M., Quan,L.T., O'Rourke,K., Desnoyers,S., Zeng,Z., Beidler,D.R., Poirier,G.G., Salvesen,G.S. and Dixit,V.M. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase Cell (1995) 81, 801-809. PubMed Europe PubMed
[YEAR:28-7-1995]Wang,X., Pai,J.T., Wiedenfeld,E.A., Medina,J.C., Slaughter,C.A., Goldstein,J.L. and Brown,M.S. Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains J Biol Chem (28-7-1995) 270, 18044-18050. PubMed Europe PubMed DOI

1994

Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1beta-converting enzyme J Biol Chem (1994) 269, 30761-30764. PubMed Europe PubMed