Literature for peptidase C14.003: caspase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Andoh,M., Shinoda,N., Taira,Y., Araki,T., Kasahara,Y., Takeuchi,H., Miura,M., Ikegaya,Y. and Koyama,R.
Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia
Nat Commun16, 918-918. PubMed Europe PubMed DOI
Shen,J., Zhang,Y., Tang,W., Yang,M., Cheng,T., Chen,Y., Yu,S., Guo,Q., Cao,L., Wang,X., Xiao,H., Wang,L., Wang,C., Liu,C.Y. and Meng,G.
Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth
Nat Immunol PubMed Europe PubMed DOI
Vidak,E., Vizovisek,M., Kavcic,N., Biasizzo,M., Fonovic,M. and Turk,B.
Apoptotic Caspases-3 and -7 Cleave Extracellular Domains of Membrane-Bound Proteins from MDA-MB-231 Breast Cancer Cells
Int J Mol Sci26, PubMed Europe PubMed DOI
Wang,X., Xie,X., Ni,J.Y., Li,J.Y., Sun,X.A., Xie,H.Y., Yang,N.H., Guo,H.J., Lu,L., Ning,M., Zhou,L., Liu,J., Xu,C., Zhang,W., Wen,Y., Shen,Q., Xu,H. and Lu,L.M.
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation
Acta Pharmacol Sin46, 159-170. PubMed Europe PubMed DOI
Wu,D., Zhang,S., Wu,Y., Bi,X., Zhou,Y. and Wu,W.
Sulforaphane downregulates mitochondrial TIGAR via inhibiting mitochondrial transmembrane assembly and LONP1/CASP3 axis causing apoptosis
Biochem Biophys Res Commun760, 151689-151689. PubMed Europe PubMed DOI K
Zhang,Z., Lin,X., Yang,Y., Wang,X., Wang,Y., Huang,X., Hong,M., Gao,W., He,H., You,M.J., Yang,Y. and Kong,G.
Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML
Cancer Biol Ther26, 2459426-2459426. PubMed Europe PubMed DOI K

2024

Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
Mol Cell84, 170-179. PubMed Europe PubMed DOI V
Bertani,F.R., Moghaddam,F.D., Panella,C., Giannitelli,S.M., Peluzzi,V., Gerardino,A., Rainer,A., Roscilli,G., De Ninno,A. and Businaro,L.
Kinetic Detection of Apoptosis Events Via Caspase 3/7 Activation in a Tumor-Immune Microenvironment on a Chip
Methods Mol Biol2748, 109-118. PubMed Europe PubMed DOI
Berthenet,K., Aimontche,E., El Mrini,S., Briere,J., Pion,N., Iacono,I., Brejon,S., Monier,K., Catez,F., Ichim,G., Combaret,V., Mertani,H.C., Diaz,J.J. and Albaret,M.A.
Spatial sequestration of activated-caspase 3 in aggresomes mediates resistance of neuroblastoma cell to bortezomib treatment
Sci Rep14, 3768-3768. PubMed Europe PubMed DOI I
Collins,J., Piscopio,R.A., Reyland,M.E., Johansen,C.G., Benninger,R.K.P. and Farnsworth,N.L.
Cleavage of protein kinase c delta by caspase-3 mediates pro-inflammatory cytokine-induced apoptosis in pancreatic islets
J Biol Chem107611-107611. PubMed Europe PubMed DOI
Fernandes,J.P., Branton,W.G., Cohen,E.A., Koopman,G., Kondova,I., Gelman,B.B. and Power,C.
Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder
Brain147, 717-734. PubMed Europe PubMed DOI K
Ge,J., Wang,Y., Li,X., Lu,Q., Yu,H., Liu,H., Ma,K., Deng,X., Luo,Z.Q., Liu,X. and Qiu,J.
Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death
Nat Commun15, 8464-8464. PubMed Europe PubMed DOI
Li,S., Song,J., Liu,J., Zhou,S., Zhao,G., Li,T., Huang,L., Li,J. and Weng,C.
African swine fever virus infection regulates pyroptosis by cleaving gasdermin A (GSDMA) via active caspase-3 and caspase-4
J Biol Chem107307-107307. PubMed Europe PubMed DOI
Pandit,S., Duchow,M., Chao,W., Capasso,A. and Samanta,D.
DNA-Barcoded Plasmonic Nanostructures for Activity-Based Protease Sensing
Angew Chem Int Ed Engl63, e202310964-e202310964. PubMed Europe PubMed DOI
Wright,S.S., Wang,C., Ta,A., Havira,M.S., Ruan,J., Rathinam,V.A. and Vanaja,S.K.
A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis
Cell Rep43, 114004-114004. PubMed Europe PubMed DOI
Xu,H., Yuan,Z., Qin,K., Jiang,S. and Sun,L.
The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
elife12, PubMed Europe PubMed DOI
Yang,J., Li,Y., Li,H., Zhang,H., Guo,H., Zheng,X., Yu,X.F. and Wei,W.
HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43
EMBO Rep25, 4337-4357. PubMed Europe PubMed DOI
Zhuang,Y., Dong,H., Liu,T., Zhao,Y., Xu,Y., Zhao,X. and Sun,D.
Highly sensitive and selective SERS detection of caspase-3 during cell apoptosis based on the target-induced hotspot effect
Analyst149, 490-496. PubMed Europe PubMed DOI

2023

Brunette,S., Sharma,A., Bell,R., Puente,L. and Megeney,L.A.
Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates
Microb Cell10, 157-169. PubMed Europe PubMed DOI
Chakraborty,S., Choudhuri,A., Mishra,A., Bhattacharyya,C., Billiar,T.R., Stoyanovsky,D.A. and Sengupta,R.
Nitric oxide and thioredoxin modulate the activity of caspase 9 in HepG2 cells
Biochim Biophys Acta Gen Subj1867, 130452-130452. PubMed Europe PubMed DOI
Dou,H., Yu,P.Y., Liu,Y.Q., Zhu,Y., Li,F.C., Wang,Y.Y., Chen,X.Y. and Xiao,M.
Recent advances in caspase-3, breast cancer, and traditional Chinese medicine: a review
J Chemother1-19. PubMed Europe PubMed DOI
Duarte-Olivenza,C., Moran,G., Hurle,J.M., Lorda-Diez,C.I. and Montero,J.A.
Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death
Cell Death Dis14, 813-813. PubMed Europe PubMed DOI
Grabert,K., Engskog-Vlachos,P., Skandik,M., Vazquez-Cabrera,G., Murgoci,A.N., Keane,L., Gaetani,M., Joseph,B. and Cheray,M.
Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate
Cell Death Dis14, 192-192. PubMed Europe PubMed DOI
Jiao,C., Zhang,H., Li,H., Fu,X., Lin,Y., Cao,C., Liu,S., Liu,Y. and Li,P.
Caspase-3/GSDME mediated pyroptosis: A potential pathway for sepsis
Int Immunopharmacol124, 111022-111022. PubMed Europe PubMed DOI V
Li,C., Pang,Y., Wang,Y., Zhou,Y., Fang,L., Xiao,S. and Qiu,D.
Cloning, expression of porcine GSDME and identification of its site cleaved by caspase-3
Biochem Biophys Res Commun669, 61-67. PubMed Europe PubMed DOI
Zhang,X., Shan,P., Otterbein,L.E., Alam,J., Flavell,R.A., Davis,R.J., Choi,A.M.K. and Lee,P.J.
Correction: Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
J Biol Chem299, 105304-105304. PubMed Europe PubMed DOI

2022

Bresinsky,M., Strasser,J.M., Vallaster,B., Liu,P., McCue,W.M., Fuller,J., Hubmann,A., Singh,G., Nelson,K.M., Cuellar,M.E., Wilmot,C.M., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S.
Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314
ACS Pharmacol Transl Sci5, 20-40. PubMed Europe PubMed DOI I
De Silva,E., Devine,D.V., Jan,E., Roskelley,C.D. and Kim,H.
Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner
Biochem J479, 2351-2364. PubMed Europe PubMed DOI
Eskandari,E. and Eaves,C.J.
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis
J Cell Biol221, PubMed Europe PubMed DOI V
Ghazavi,F., Huysentruyt,J., De Coninck,J., Kourula,S., Martens,S., Hassannia,B., Wartewig,T., Divert,T., Roelandt,R., Popper,B., Hiergeist,A., Tougaard,P., Vanden Berghe,T., Joossens,M., Berx,G., Takahashi,N., Wahida,A. and Vandenabeele,P.
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state
Proc Natl Acad Sci U S A119, PubMed Europe PubMed DOI
Hung,M.C., Wang,W.P. and Chi,Y.H.
AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer
Cell Biosci12, 122-122. PubMed Europe PubMed DOI
Rahimi,A., Karimipoor,M., Mahdian,R., Alipour,A., Hosseini,S., Kaghazian,H., Abbasi,A., Shahsavarani,H. and Shokrgozar,M.A.
Targeting Caspase-3 Gene in rCHO Cell Line by CRISPR/Cas9 Editing Tool and Its Effect on Protein Production in Manipulated Cell Line
Iran J Pharm Res21, e130236-e130236. PubMed Europe PubMed DOI
Roychowdhury,H. and Romero,P.A.
Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation
Cell Death Discov8, 7-7. PubMed Europe PubMed DOI
Silva,F.F.V.E., Padin-Iruegas,M.E., Caponio,V.C.A., Lorenzo-Pouso,A.I., Saavedra-Nieves,P., Chamorro-Petronacci,C.M., Suarez-Penaranda,J. and Perez-Sayans,M.
Caspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis
Int J Mol Sci23, PubMed Europe PubMed DOI V
Weir,A. and Vince,J.E.
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death
Biochem J479, 1083-1102. PubMed Europe PubMed DOI V
Ye,X., Li,Y., Lv,B., Qiu,B., Zhang,S., Peng,H., Kong,W., Tang,C., Huang,Y., Du,J. and Jin,H.
Endogenous Hydrogen Sulfide Persulfidates Caspase-3 at Cysteine 163 to Inhibit Doxorubicin-Induced Cardiomyocyte Apoptosis
Oxid Med Cell Longev2022, 6153772-6153772. PubMed Europe PubMed DOI
Zichittella,C., Barreca,M.M., Cordaro,A., Corrado,C., Alessandro,R. and Conigliaro,A.
Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells
BMC Cancer22, 567-567. PubMed Europe PubMed DOI

2021

Anson,F., Kanjilal,P., Thayumanavan,S. and Hardy,J.A.
Tracking exogenous intracellular casp-3 using split GFP
Protein Sci30, 366-380. PubMed Europe PubMed DOI
Asadi,M., Taghizadeh,S., Kaviani,E., Vakili,O., Taheri-Anganeh,M., Tahamtan,M. and Savardashtaki,A.
Caspase-3: Structure, function, and biotechnological aspects
Biotechnol Appl Biochem PubMed Europe PubMed DOI V
Awazu,M., Yamaguchi,Y., Nagata,M., Miura,M. and Hida,M.
Caspase-3 regulates ureteric branching in mice via cell migration
Biochem Biophys Res Commun559, 28-34. PubMed Europe PubMed DOI
Burgener,S.S., Brugger,M., Leborgne,N.G.F., Sollberger,S., Basilico,P., Kaufmann,T., Bird,P.I. and Benarafa,C.
Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
Front Cell Dev Biol9, 630166-630166. PubMed Europe PubMed DOI
Du,Y., Taylor,C.G., Aukema,H.M. and Zahradka,P.
Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases
Biochim Biophys Acta Mol Cell Biol Lipids1866, 158902-158902. PubMed Europe PubMed DOI
Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
Int J Mol Sci22, PubMed Europe PubMed DOI
Kim,J.E., Park,H., Kim,T.H. and Kang,T.C.
LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus
Int J Mol Sci22, PubMed Europe PubMed DOI K
Kim,Y.H., Hwang,J.S., Yoon,I.N., Lee,J.H., Lee,J., Park,K.C., Seok,H. and Kim,H.
The insect peptide CopA3 blocks programmed cell death by directly binding caspases and inhibiting their proteolytic activation
Biochem Biophys Res Commun547, 82-88. PubMed Europe PubMed DOI
Maluch,I., Grzymska,J., Snipas,S.J., Salvesen,G.S. and Drag,M.
Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7
Biochem J478, 2233-2245. PubMed Europe PubMed DOI
Mao,Y., Qiao,J.D., Chen,S., Zhou,X., Wang,Z., Cai,S., Li,L. and Luo,Y.
Kallistatin Inhibits Anoikis Resistance and Metastasis of Ectopic Endometrium Cells by Modulating MnSOD and Caspase 3 Signaling
Reprod Sci PubMed Europe PubMed DOI
Ozdemir,A., Ibisoglu,B., Simay Demir,Y.D., Benhur,E., Valipour,F. and Ark,M.
A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2
Biochem Biophys Res Commun547, 118-124. PubMed Europe PubMed DOI
Shao,B., Zheng,L., Shi,J. and Sun,N.
Acetylation of ANXA1 reduces caspase-3 activation by enhancing the phosphorylation of caspase-9 under OGD/R conditions
Cell Signal88, 110157-110157. PubMed Europe PubMed DOI
Soni,I.V. and Hardy,J.A.
Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence
Biochemistry60, 2824-2835. PubMed Europe PubMed DOI
Voss,T.D., Gerget,M., Linkus,B., von Einem,B., Landwehrmeyer,G.B. and Lewerenz,J.
Ubiquitination and the Proteasome rather than Caspase-3-Mediated C-Terminal Cleavage are Involved in the EAAT2 Degradation by Staurosporine-Induced Cellular Stress
J Neurochem157, 1284-1299. PubMed Europe PubMed DOI
Zhang,L.S., Xu,H.L., Xia,Y., Bi,J.P., Zhang,C.Z., Xi,Z., Li,L.Y. and Zhang,Z.S.
Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells
Chem Commun (Camb)57, 797-800. PubMed Europe PubMed DOI
Zhang,Z., Bao,X. and Li,D.
Batroxobin inhibits astrocyte activation following nigrostriatal pathway injury
Neural Regen Res16, 721-726. PubMed Europe PubMed DOI

2020

Akhigbe,R.E., Ajayi,L.O., Adelakun,A.A., Olorunnisola,O.S. and Ajayi,A.F.
Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis
Mol Biol Rep47, 9521-9530. PubMed Europe PubMed DOI
Akpinar,O., Ozsimsek,A., Guzel,M. and Naziroglu,M.
Clostridium botulinum neurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells
J Recept Signal Transduct Res1-13. PubMed Europe PubMed DOI
Almeida,C.P., Silveira,C.O., Ferreira,E.F., Ferreira,M.C., Oliveira,G.G., Veloso,E.S., Silva,F.H.S., Coelho,S.S., Moraes,L.M., Reis,F.M. and Del Puerto,H.L.
Pro-caspase-3 is constitutively expressed in luteinized granulosa cells from women undergoing controlled ovarian stimulation for in vitro fertilization
Acta Histochem123, 151670-151670. PubMed Europe PubMed DOI
Ando,S., Tanaka,M., Chinen,N., Nakamura,S., Shimazawa,M. and Hara,H.
SMN Protein Contributes to Skeletal Muscle Cell Maturation Via Caspase-3 and Akt Activation
In Vivo34, 3247-3254. PubMed Europe PubMed DOI
Balboula,A.Z., Schindler,K., Kotani,T., Kawahara,M. and Takahashi,M.
Vitrification-induced activation of lysosomal cathepsin B perturbs spindle assembly checkpoint function in mouse oocytes
Mol Hum Reprod PubMed Europe PubMed DOI
Benitez-Rangel,E., Olguin-Albuerne,M., Lopez-Mendez,M.C., Dominguez-Macouzet,G., Guerrero-Hernandez,A. and Moran,J.
Caspase-3 Activation Correlates With the Initial Mitochondrial Membrane Depolarization in Neonatal Cerebellar Granule Neurons
Front Cell Dev Biol8, 544-544. PubMed Europe PubMed DOI
Changizi,Z., Moslehi,A., Rohani,A.H. and Eidi,A.
Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice
J Biochem Mol Toxicole22642-e22642. PubMed Europe PubMed DOI
Chao,C.M., Chen,C.L., Niu,K.C., Lin,C.H., Tang,L.Y., Lin,L.S. and Chang,C.P.
Hypobaric hypoxia preconditioning protects against hypothalamic neuron apoptosis in heat-exposed rats by reversing hypothalamic overexpression of matrix metalloproteinase-9 and ischemia
Int J Med Sci17, 2622-2634. PubMed Europe PubMed DOI
Chen,X., Chen,D., Huang,L., Chen,X., Zhou,M., Xi,X., Ma,C., Chen,T. and Wang,L.
Identification and Target-Modification of SL-BBI: A Novel Bowman-Birk Type Trypsin Inhibitor from Sylvirana latouchii
Biomolecules10, PubMed Europe PubMed DOI
Chen,X., Ji,S., Si,J., Zhang,X., Wang,X., Guo,Y. and Zou,X.
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis
Mol Med Rep22, 5243-5250. PubMed Europe PubMed DOI
Chu,Y., Dong,X., Kang,Y., Liu,J., Zhang,T., Yang,C., Wang,Z., Shen,W., Huo,H., Zhuang,M., Lu,J. and Liu,Y.
The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B
iScience23, 101708-101708. PubMed Europe PubMed DOI K
Chuang,H.C., Chen,Y.Y., Hsiao,T.C., Chou,H.C., Kuo,H.P., Feng,P.H., Ho,S.C., Chen,J.K., Chuang,K.J. and Lee,K.Y.
Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats
ERJ Open Res6, PubMed Europe PubMed DOI
Corrigan,T.S., Lotti Diaz,L.M., Border,S.E., Ratigan,S.C., Kasper,K.Q., Sojka,D., Fajtova,P., Caffrey,C.R., Salvesen,G.S., McElroy,C.A., Hadad,C.M. and Dogan Ekici,O.
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
J Enzyme Inhib Med Chem35, 1387-1402. PubMed Europe PubMed DOI I
Cui,X.Y., Park,S.H. and Park,W.H.
Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspasedependent apoptosis
Oncol Rep44, 2715-2724. PubMed Europe PubMed DOI I
de Vasconcelos,N.M., Van Opdenbosch,N., Van Gorp,H., Martin-Perez,R., Zecchin,A., Vandenabeele,P. and Lamkanfi,M.
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Rep32, 107959-107959. PubMed Europe PubMed DOI
Diao,W., Guo,Q., Zhu,C., Song,Y., Feng,H., Cao,Y., Du,M. and Chen,H.
USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway
BMC Cancer20, 741-741. PubMed Europe PubMed DOI
Ding,Z., Wei,Q., Zhang,C., Zhang,H. and Huang,F.
Influence of oxidation on heat shock protein 27 translocation, caspase-3 and calpain activities and myofibrils degradation in postmortem beef muscles
Food Chem340, 127914-127914. PubMed Europe PubMed DOI
Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y.
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer
Onco Targets Ther13, 8495-8510. PubMed Europe PubMed DOI L
Duan,L., Zuo,J., Zhang,F., Li,B., Xu,Z., Zhang,H., Yang,B., Song,W. and Jiang,J.
Magnetic Targeting of HU-MSCs in the Treatment of Glucocorticoid-Associated Osteonecrosis of the Femoral Head Through Akt/Bcl2/Bad/Caspase-3 Pathway
Int J Nanomedicine15, 3605-3620. PubMed Europe PubMed DOI
Eslami,F., Mahdavi,M., Babaei,E., Hussen,B.M., Mostafavi,H., Shahbazi,A. and Hidayat,H.J.
Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family
Toxicol Appl Pharmacol409, 115331-115331. PubMed Europe PubMed DOI
Firoozpour,L., Gao,L., Moghimi,S., Pasalar,P., Davoodi,J., Wang,M.W., Rezaei,Z., Dadgar,A., Yahyavi,H., Amanlou,M. and Foroumadi,A.
Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors
J Enzyme Inhib Med Chem35, 1674-1684. PubMed Europe PubMed DOI I
Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J.
Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection
Fish Shellfish Immunol PubMed Europe PubMed DOI I
Fujisawa,Y., Shinoda,N., Chihara,T. and Miura,M.
ROS Regulate Caspase-Dependent Cell Delamination without Apoptosis in the Drosophila Pupal Notum
iScience23, 101413-101413. PubMed Europe PubMed DOI
Gao,H., Wen,N., Xu,X., Hong,G. and Lai,X.
[Endoplasmic reticulum stress enhances tumor necrosis factor-alpha expression in rat Kupffer cells to trigger hepatic stellate apoptosis cell through TNFR/caspase-8 pathway]
Nan Fang Yi Ke Da Xue Xue Bao40, 632-639. PubMed Europe PubMed DOI
Garcia-Arguello,S.F., Lopez-Lorenzo,B., Cornelissen,B. and Smith,G.
Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
Cancers (Basel)12, PubMed Europe PubMed DOI V
Garcia-Dominguez,I., Suarez-Pereira,I., Santiago,M., Perez-Villegas,E.M., Bravo,L., Lopez-Martin,C., Roca-Ceballos,M.A., Garcia-Revilla,J., Espinosa-Oliva,A.M., Rodriguez-Gomez,J.A., Joseph,B., Berrocoso,E., Armengol,J.A., Venero,J.L., Ruiz,R. and de Pablos,R.M.
Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
Prog Neuropsychopharmacol Biol Psychiatry104, 110030-110030. PubMed Europe PubMed DOI K
Geng,D., Ciavattone,N., Lasola,J.J., Shrestha,R., Sanchez,A., Guo,J., Vlk,A., Younis,R., Wang,L., Brown,A.J., Zhang,Y., Velasco-Gonzalez,C., Tan,A.C. and Davila,E.
Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels
Commun Biol3, 306-306. PubMed Europe PubMed DOI
Gu,J., Zhan,A.J., Jiang,J.L., Chen,Y., Xu,J., Ye,L. and Mao,M.G.
Conserved function of Pacific cod caspase-3 in apoptosis
Gene732, 144370-144370. PubMed Europe PubMed DOI
Guo,X., Bai,X., Zhang,F., Zheng,L., Ding,W. and Yang,S.
Resveratrol protects against apoptosis induced by interleukin-1beta in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3beta/caspase-3 pathways
Biosci Rep40, PubMed Europe PubMed DOI I
Haque,M.E., Akther,M., Azam,S., Choi,D.K. and Kim,I.S.
GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell
Int J Mol Sci21, PubMed Europe PubMed DOI
Hu,Y., Ma,Z., Chen,Z. and Chen,B.
USP47 promotes apoptosis in rat myocardial cells after ischemia/reperfusion injury via NF-kappaB activation
Biotechnol Appl Biochem PubMed Europe PubMed DOI K
Huo,W., Yu,J., Liu,C., Wu,T., Wang,Y., Meng,X., Song,F., Zhang,S., Su,Y., Liu,Y., Liu,J., Yu,X. and Hua,S.
Caspase-3 inhibitor inhibits enterovirus D68 production
J Microbiol58, 812-820. PubMed Europe PubMed DOI I
Ismy,J., Sugandi,S., Rachmadi,D., Hardjowijoto,S. and Mustafa,A.
The Effect of Exogenous Superoxide Dismutase (SOD) on Caspase-3 Activation and Apoptosis Induction in Pc-3 Prostate Cancer Cells
Res Rep Urol12, 503-508. PubMed Europe PubMed DOI
Jantas,D., Chwastek,J., Malarz,J., Stojakowska,A. and Lason,W.
Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition
Biomolecules10, PubMed Europe PubMed DOI
Jin,B., Liu,J., Gao,D., Xu,Y., He,L., Zang,Y., Li,N. and Lin,D.
Detailed studies on the anticancer action of rosmarinic acid in human Hep-G2 liver carcinoma cells: evaluating its effects on cellular apoptosis, caspase activation and suppression of cell migration and invasion
J BUON25, 1383-1389. PubMed Europe PubMed
Jin,Q., Lin,C., Zhu,X., Cao,Y., Guo,C. and Wang,L.
(125)I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts
Radiat Oncol15, 238-238. PubMed Europe PubMed DOI
Ke,H., Wang,X., Zhou,Z., Ai,W., Wu,Z. and Zhang,Y.
Effect of weimaining on apoptosis and Caspase-3 expression in a breast cancer mouse model
J Ethnopharmacol264, 113363-113363. PubMed Europe PubMed DOI
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Wolin,I.A.V., Heinrich,I.A., Nascimento,A.P.M., Welter,P.G., Sosa,L.D.V., De Paul,A.L., Zanotto-Filho,A., Nedel,C.B., Lima,L.D., Osterne,V.J.S., Pinto-Junior,V.R., Nascimento,K.S., Cavada,B.S. and Leal,R.B.
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Yardim,A., Kandemir,F.M., Ozdemir,S., Kucukler,S., Comakli,S., Gur,C. and Celik,H.
Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways
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Yossef,R.R., Al-Yamany,M.F., Saad,M.A. and El-Sahar,A.E.
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Yu,H., Sun,Q., Yun,F., Xu,X., Ding,F., Li,S. and Zhao,P.
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Zhang,Y., Chen,Z., Li,X., He,J., Liu,Z. and Yang,L.
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2019

Expression of Concern: alpha-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3
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Checker,R., Pal,D., Patwardhan,R.S., Basu,B., Sharma,D. and Sandur,S.K.
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Chen,Y.L., Han,K., Huang,X., Zhang,Z., Wan,X. and Ren,Q.
Caspase-3C gene from red swamp crayfish, Procambarus clarki: characterization and expression in response to pathogenic infection
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Clark,A.M., Ponniah,K., Warden,M.S., Raitt,E.M., Smith,B.G. and Pascal,S.M.
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Eda,S.R., Veeramachaneni,G.K., Bondili,J.S. and Jinka,R.
Screening of caspase-3 inhibitors from natural molecule database using e-pharmacophore and docking studies
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Huan,L.C., Phuong,C.V., Truc,L.C., Thanh,V.N., Pham-The,H., Huong,L.T., Thuan,N.T., Park,E.J., Ji,A.Y., Kang,J.S., Han,S.B., Tran,P.T. and Nam,N.H.
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Kashaw,S.K., Agarwal,S., Mishra,M., Sau,S. and Iyer,A.K.
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Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: rational design, one-pot tricomponent synthesis, and lipophilicity determination
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Van Kersavond,T., Konopatzki,R., Chakrabarty,S., Blank-Landeshammer,B., Sickmann,A. and Verhelst,S.H.L.
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Zhang,Q., Schepis,A., Huang,H., Yang,J., Ma,W., Torra,J., Zhang,S.Q., Yang,L., Wu,H., Nonell,S., Dong,Z., Kornberg,T.B., Coughlin,S.R. and Shu,X.
Designing a green fluorogenic protease reporter by flipping a beta strand of GFP for imaging apoptosis in animals
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Zhao,C., Qiu,L., Lv,P., Han,A., Fang,G., Liu,J. and Wang,S.
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2018

Akazawa,K., Sugihara,F., Nakamura,T., Mizukami,S. and Kikuchi,K.
Highly sensitive detection of caspase-3/7 activity in living mice using enzyme-responsive (19)F MRI nanoprobes
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Buschhaus,J.M., Humphries,B., Luker,K.E. and Luker,G.D.
A caspase-3 reporter for fluorescence lifetime imaging of single-cell apoptosis
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Engel,B.J., Gammon,S.T., Chaudhari,R., Lu,Z., Pisaneschi,F., Yang,H., Ornelas,A., Yan,V., Kelderhouse,L., Najjar,A.M., Tong,W.P., Zhang,S., Piwnica-Worms,D., Bast RC Jr and Millward,S.W.
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Yang,B., Lan,S., Dieude,M., Sabo-Vatasescu,J.P., Karakeussian-Rimbaud,A., Turgeon,J., Qi,S., Gunaratnam,L., Patey,N. and Hebert,M.J.
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Zherdeva,V., Kazachkina,N.I., Shcheslavskiy,V. and Savitsky,A.P.
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2017

Cheng,H., Li,S.Y., Zheng,H.R., Li,C.X., Xie,B.R., Chen,K.W., Li,B. and Zhang,X.Z.
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Poreba,M., Salvesen,G.S. and Drag,M.
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
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Rogers,C., Fernandes-Alnemri,T., Mayes,L., Alnemri,D., Cingolani,G. and Alnemri,E.S.
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
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Rosenblum,L.T., Shamamandri-Markandaiah,S., Ghosh,B., Foran,E., Lepore,A.C., Pasinelli,P. and Trotti,D.
Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS
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Shen,X., Burguillos,M.A. and Joseph,B.
Guilt by association, caspase-3 regulates microglia polarization
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Smart,A.D., Pache,R.A., Thomsen,N.D., Kortemme,T., Davis,G.W. and Wells,J.A.
Engineering a light-activated caspase-3 for precise ablation of neurons in vivo
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Su,D., Hu,X., Dong,C. and Ren,J.
Determination of caspase-3 activity and its inhibition constant by combination of fluorescence correlation spectroscopy with a microwell chip
Anal Chem89, 9788-9796. PubMed Europe PubMed DOI A
Vaidya,A., Jain,A.K., Prashantha Kumar,B.R., Sastry,G.N., Kashaw,S.K. and Agrawal,R.K.
CoMFA, CoMSIA, kNN MFA and docking studies of 1,2,4-oxadiazole derivatives as potent caspase-3 activators
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
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Yang,Y., Liang,Y. and Zhang,C.Y.
Label-free and homogenous detection of caspase-3-like proteases by disrupting homodimerization-directed bipartite tetracysteine display
Anal Chem89, 4055-4061. PubMed Europe PubMed DOI A

2016

Baek,H.J., Lee,Y.M., Kim,T.H., Kim,J.Y., Park,E.J., Iwabuchi,K., Mishra,L. and Kim,S.S.
Caspase-3/7-mediated cleavage of beta2-spectrin is required for acetaminophen-induced liver damage
Int J Biol Sci12, 172-183. PubMed Europe PubMed DOI
Burgess,J.T., Bolderson,E., Adams,M.N., Baird,A.M., Zhang,S.D., Gately,K.A., Umezawa,K., O'Byrne,K.J. and Richard,D.J.
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
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Hajimahdi,Z., Safizadeh,F. and Zarghi,A.
Qsar analysis for some 1, 2-benzisothiazol-3-one derivatives as caspase-3 inhibitors by stepwise mlr method
Iran J Pharm Res15, 439-448. PubMed Europe PubMed I
Hwang,D., Kim,S.A., Yang,E.G., Song,H.K. and Chung,H.S.
A facile method to prepare large quantities of active caspase-3 overexpressed by auto-induction in the C41(DE3) strain
Protein Expr Purif126, 104-108. PubMed Europe PubMed DOI E
Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Proc Natl Acad Sci U S A113, E2001-E2010. PubMed Europe PubMed DOI P
Khalilzadeh,B., Charoudeh,H.N., Shadjou,N., Mohammad-Rezaei,R., Omidi,Y., Velaei,K., Aliyari,Z. and Rashidi,M.-R.
Ultrasensitive caspase-3 activity detection using an electrochemical biosensor engineered by gold nanoparticle functionalized MCM-41: Its application during stem cell differentiation
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Maciag,J.J., MacKenzie,S.H., Tucker,M.B., Schipper,J.L., Swartz,P. and Clark,A.C.
Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection
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Mackay,M., Perez-Lopez,A.M., Bradley,M. and Lilienkampf,A.
Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates
Mol Biosyst12, 693-696. PubMed Europe PubMed DOI A
Perez-Lopez,A.M., Soria-Gila,M.L., Marsden,E.R., Lilienkampf,A. and Bradley,M.
Fluorogenic substrates for in situ monitoring of caspase-3 activity in live cells
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Seaman,J.E., Julien,O., Lee,P.S., Rettenmaier,T.J., Thomsen,N.D. and Wells,J.A.
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues
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To,T.L., Schepis,A., Ruiz-Gonzalez,R., Zhang,Q., Yu,D., Dong,Z., Coughlin,S.R. and Shu,X.
Rational design of a GFP-based fluorogenic caspase reporter for imaging apoptosis in vivo
Cell Chem Biol23, 875-882. PubMed Europe PubMed DOI L
Tucker,M.B., MacKenzie,S.H., Maciag,J.J., Dirscherl Ackerman,H., Swartz,P., Yoder,J.A., Hamilton,P.T. and Clay Clark,A.
Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish
Protein Sci25, 2076-2088. PubMed Europe PubMed DOI P S
Wang,C., Ye,M., Wei,X., Bian,Y., Cheng,K. and Zou,H.
A bead-based cleavage method for large-scale identification of protease substrates
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Zlobovskaya,O.A., Sergeeva,T.F., Shirmanova,M.V., Dudenkova,V.V., Sharonov,G.V., Zagaynova,E.V. and Lukyanov,K.A.
Genetically encoded far-red fluorescent sensors for caspase-3 activity
Biotechniques60, 62-68. PubMed Europe PubMed DOI L

2015

Alasia,S., Cocito,C., Merighi,A. and Lossi,L.
Real-time visualization of caspase-3 activation by fluorescence resonance energy transfer (FRET)
Methods Mol Biol1254, 99-113. PubMed Europe PubMed DOI L
Cailliau,K., Lescuyer,A., Burnol,A.F., Cuesta-Marban,A., Widmann,C. and Browaeys-Poly,E.
RasGAP shields Akt from deactivating phosphatases in fibroblast growth factor signaling but loses this ability once cleaved by caspase-3
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2014

Adamova,E., Liskova,M., Matalova,E. and Kleparnik,K.
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2013

Adamova,E., Kleparnik,K. and Matalova,E.
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2012

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2011

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2009

Agniswamy,J., Fang,B. and Weber,I.T.
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2008

Abdul-Ghani,M. and Megeney,L.A.
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Kim,K.W., Moretti,L. and Lu,B.
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Sharma,S., Sahu,K., Jain,P., Mourya,V.K. and Agrawal,R.K.
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2007

Aulabaugh,A., Kapoor,B., Huang,X., Dollings,P., Hum,W.T., Banker,A., Wood,A. and Ellestad,G.
Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry
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Geminin is cleaved by caspase-3 during apoptosis in Xenopus egg extracts
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Chu,W., Rothfuss,J., d'Avignon,A., Zeng,C., Zhou,D., Hotchkiss,R.S. and Mach,R.H.
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Halle,M., Liu,Y.C., Hardy,S., Theberge,J.F., Blanchetot,C., Bourdeau,A., Meng,T.C. and Tremblay,M.L.
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Ju,W., Valencia,C.A., Pang,H., Ke,Y., Gao,W., Dong,B. and Liu,R.
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Kuzelova,K., Grebenova,D. and Hrkal,Z.
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Li,X., Fan,R., Zou,X., Gao,L., Jin,H., Du,R., Xia,L. and Fan,D.
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2006

Boston-Howes,W., Gibb,S.L., Williams,E.O., Pasinelli,P., Brown,R.H., Jr. and Trotti,D.
Caspase-3 cleaves and inactivates the glutamate transporter EAAT2
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Protease specificity determination by using cellular libraries of peptide substrates (CLiPS)
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Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors
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Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10
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Fang,B., Boross,P.I., Tozser,J. and Weber,I.T.
Structural and kinetic analysis of caspase-3 reveals role for S5 binding site in substrate recognition
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Ganesan,R., Mittl,P.R., Jelakovic,S. and Grutter,M.G.
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
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2005

Balsam,L.B., Kofidis,T. and Robbins,R.C.
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[YEAR:1-12-2005]Chu,W., Zhang,J., Zeng,C., Rothfuss,J., Tu,Z., Chu,Y., Reichert,D.E., Welch,M.J. and Mach,R.H.
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies
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Using peptidic inhibitors to systematically probe the S1' site of caspase-3 and caspase-7
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Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors
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1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors
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Mitchell,D.A. and Marletta,M.A.
Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine
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Petrassi,H.M., Williams,J.A., Li,J., Tumanut,C., Ek,J., Nakai,T., Masick,B., Backes,B.J. and Harris,J.L.
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2004

[YEAR:15-2-2004]Aouad,S.M., Cohen,L.Y., Sharif-Askari,E., Haddad,E.K., Alam,A. and Sekaly,R.P.
Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death
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J Med Chem47, 2466-2474. PubMed Europe PubMed DOI I
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Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis
J Biol Chem279, 27542-27548. PubMed Europe PubMed DOI P
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Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo
J Virol78, 11040-11050. PubMed Europe PubMed DOI I
Du,J., Wang,X., Miereles,C., Bailey,J.L., Debigare,R., Zheng,B., Price,S.R. and Mitch,W.E.
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Design and synthesis of photochemically controllable caspase-3
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Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3
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Discovery of an allosteric site in the caspases
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Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia
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Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3
J Med Chem47, 6455-6458. PubMed Europe PubMed DOI I
Miura,M., Chen,X.D., Allen,M.R., Bi,Y., Gronthos,S., Seo,B.M., Lakhani,S., Flavell,R.A., Feng,X.H., Robey,P.G., Young,M. and Shi,S.
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
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[YEAR:15-11-2004]Mueller,T.H., Kienle,K., Beham,A., Geissler,E.K., Jauch,K.W. and Rentsch,M.
Caspase 3 inhibition improves survival and reduces early graft injury after ischemia and reperfusion in rat liver transplantation
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Nicholson,D. and Thornberry,N.A.
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Rearrangement of tryptophan residues in caspase-3 active site upon activation
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Paroni,G., Mizzau,M., Henderson,C., del Sal,G., Schneider,C. and Brancolini,C.
Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis
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Caspase 3 activation is controlled by a sequence located in the N-terminus of its large subunit
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Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3
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2003

[YEAR:28-10-2003]Bose,K., Pop,C., Feeney,B. and Clark,A.C.
An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3
Biochemistry42, 12298-12310. PubMed Europe PubMed DOI
Chen,L., Smith,L., Wang,Z. and Smith,J.B.
Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination
Mol Pharmacol64, 334-345. PubMed Europe PubMed DOI
Erlanson,D.A., Lam,J.W., Wiesmann,C., Luong,T.N., Simmons,R.L., DeLano,W.L., Choong,I.C., Burdett,M.T., Flanagan,W.M., Lee,D., Gordon,E.M. and O'Brien,T.
In situ assembly of enzyme inhibitors using extended tethering
Nat Biotechnol21, 308-314. PubMed Europe PubMed DOI I
Gianinazzi,C., Grandgirard,D., Imboden,H., Egger,L., Meli,D.N., Bifrare,Y.D., Joss,P.C., Tauber,M.G., Borner,C. and Leib,S.L.
Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis
Acta Neuropathol (Berl)105, 499-507. PubMed Europe PubMed DOI I
Isabel,E., Black,W.C., Bayly,C.I., Grimm,E.L., Janes,M.K., McKay,D.J., Nicholson,D.W., Rasper,D.M., Renaud,J., Roy,S., Tam,J., Thornberry,N.A., Vaillancourt,J.P., Xanthoudakis,S. and Zamboni,R.
Nicotinyl aspartyl ketones as inhibitors of caspase-3
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[YEAR:28-3-2003]Kook,S., Kim,D.H., Shim,S.R., Kim,W., Chun,J.S. and Song,W.K.
Caspase-dependent cleavage of tensin induces disruption of actin cytoskeleton during apoptosis
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[YEAR:5-6-2003]McKay,T.R., Bell,S., Tenev,T., Stoll,V., Lopes,R., Lemoine,N.R. and McNeish,I.A.
Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A; a combination gene therapy strategy
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Ni,C.Z., Li,C., Wu,J.C., Spada,A.P. and Ely,K.R.
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Mutations in the procaspase-3 dimer interface affect the activity of the zymogen
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Reaction mechanism of caspases: insights from QM/MM Car-Parrinello simulations
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Sulpizi,M., Rothlisberger,U. and Carloni,P.
Molecular dynamics studies of caspase-3
Biophys J84, 2207-2215. PubMed Europe PubMed DOI
Woo,M., Hakem,R., Furlonger,C., Hakem,A., Duncan,G.S., Sasaki,T., Bouchard,D., Lu,L., Wu,G.E., Paige,C.J. and Mak,T.W.
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
Nat Immunol4, 1016-1022. PubMed Europe PubMed DOI

2002

[YEAR:1-3-2002]Anantharam,V., Kitazawa,M., Wagner,J., Kaul,S. and Kanthasamy,A.G.
Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl
J Neurosci22, 1738-1751. PubMed Europe PubMed I
Back,S.H., Shin,S. and Jang,S.K.
Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis
J Biol Chem277, 27200-27209. PubMed Europe PubMed DOI
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A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury
Eur J Pharmacol456, 59-68. PubMed Europe PubMed DOI I
[YEAR:7-11-2002]Choong,I.C., Lew,W., Lee,D., Pham,P., Burdett,M.T., Lam,J.W., Wiesmann,C., Luong,T.N., Fahr,B., DeLano,W.L., McDowell,R.S., Allen,D.A., Erlanson,D.A., Gordon,E.M. and O'Brien,T.
Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design
J Med Chem45, 5005-5022. PubMed Europe PubMed DOI I
[YEAR:29-7-2002]Kyoung,M., Kim,S.Y., Seok,H.Y., Park,I.S. and Lee,M.
Probing the caspase-3 active site by fluorescence lifetime measurements
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Identification and functional analysis of the rat caspase-3 gene promoter
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McCollum,A.T., Nasr,P. and Estus,S.
Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death
J Neurochem82, 1208-1220. PubMed Europe PubMed DOI I
Pelizon,C., d'Adda di Fagagna,F., Farrace,L. and Laskey,R.A.
Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis
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Zeng,L. and Smith,L.D.
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Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis
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2001

[YEAR:26-1-2001]Affar,E.B., Germain,M., Winstall,E., Vodenicharov,M., Shah,R.G., Salvesen,G.S. and Poirier,G.G.
Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis
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[YEAR:3-4-2001]Barkett,M., Dooher,J.E., Lemonnier,L., Simmons,L., Scarpati,J.N., Wang,Y. and Gilmore,T.D.
Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3
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Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes
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Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2
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Long-term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors
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Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo
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Jiang,D.M., Jha,N., Boonplueang,R. and Andersen,J.K.
Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells
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Kang,K.H., Lee,K.H., Kim,M.Y. and Choi,K.H.
Caspase-3-mediated cleavage of the NF-kappa B subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis
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Potent and selective nonpeptide inhibitors of caspases 3 and 7
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MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
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Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis
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2000

Bushell,M., Poncet,D., Marissen,W.E., Flotow,H., Lloyd,R.E., Clemens,M.J. and Morley,S.J.
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1999

Bajusz,S., Fauszt,I., Nemeth,K., Barabas,E., Juhasz,A., Patthy,M. and Bauer,P.I.
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1998

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1997

Akita,K., Ohtsuki,T., Nukada,Y., Tanimoto,T., Namba,M., Okura,T., Takakura-Yamamoto,R., Torigoe,K., Gu,Y., Su,M.S., Fujii,M., Satoh-Itoh,M., Yamamoto,K., Kohno,K., Ikeda,M. and Kurimoto,M.
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1996

Bullrich,F., Fernandes-Alnemri,T., Litwack,G., Alnemri,E.S. and Croce,C.M.
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1995

Nicholson,D.W., Ali,A., Thornberry,N.A., Vaillancourt,J.P., Ding,C.K., Gallant,M., Gareau,Y., Griffin,P.R., Labelle,M., Lazebnik,Y.A., Munday,N.A., Raju,S.M., Smulson,M.E., Yamin,T.T., Yu,V.L. and Miller,D.K.
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1994

Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
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