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Literature for peptidase C13.004: legumain, animal-type

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chen,J., Xu,W., Meng,L., Zhang,X., Lin,M., Zhang,S., Liu,Y. and Guo,F.
    The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism
    J Cell Mol Med29, e70616-e70616. PubMed  Europe PubMed DOI
  2. Liu,Y., Liu,W., Guo,C., Bao,J., Zhang,H., Li,W., Li,Y., Gui,Y., Zeng,Y., Wang,X., Peng,C., Shu,X. and Liu,R.
    AENK ameliorates cognitive impairment and prevents Tau hyperphosphorylation through inhibiting AEP-mediated cleavage of SET in rats with ischemic stroke
    J Neurochem169, e16283-e16283. PubMed  Europe PubMed DOI
  3. McGlinchey,R.P., Ramos,S., Dimitriadis,E.K., Wilson,C.B. and Lee,J.C.
    Defining essential charged residues in fibril formation of a lysosomal derived N-terminal alpha-synuclein truncation
    Nat Commun16, 3825-3825. PubMed  Europe PubMed DOI
  4. Morillo-Huesca,M., Lopez-Cepero,G., Conesa-Bakkali,R., Tome,M., Watts,C., Huertas,P., Moreno-Bueno,G., Duran,R.V. and Martinez-Fabregas,J.
    Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer
    J Exp Clin Cancer Res44, 74-74. PubMed  Europe PubMed DOI
  5. Zhao,J., Wu,L., Cai,G., Ou,D., Liao,K., Yang,J., Zhou,L., Huang,R., Lin,S., Huang,X., Lv,Q., Chen,J., Cao,L., Chen,J. and Lin,Y.
    Targeting PGE2 mediated senescent neuron improves tumour therapy
    Neuro Oncol PubMed  Europe PubMed DOI
    6. 2024
  6. Alexander,M.R. and Harrison,D.G.
    Legumain Regulates Regulatory T Cells in Hypertension
    Circ Res134, 30-32. PubMed  Europe PubMed DOI
  7. Forbord,K.M., Lunde,N.N., Bosnjak-Olsen,T., Johansen,H.T., Solberg,R. and Jafari,A.
    Legumain is a paracrine regulator of osteoblast differentiation and mediates the inhibitory effect of TGF-beta1 on osteoblast maturation
    Front Endocrinol (Lausanne)15, 1445049-1445049. PubMed  Europe PubMed DOI
  8. Hua,D., Xi,H., Xie,Q., Cai,S., Zhou,Y., Hu,X., Qiu,L. and Lin,J.
    Lysosome-targeting and legumain-triggered (68)Ga-labeled probe for enhanced tumor PET imaging
    Biochem Biophys Res Commun703, 149646-149646. PubMed  Europe PubMed DOI
  9. Osoble,N.M.M., Lunde,N.N., Jafari,A., Thoresen,G.H., Solberg,R. and Rustan,A.C.
    The cysteine protease legumain decreases glucose metabolism and enhances fatty acid uptake in human myotubes
    Biochimie PubMed  Europe PubMed DOI
  10. Singh,M., Steinke,I. and Amin,R.H.
    Structure-based computer-aided drug design to identify potential lead molecules for Asparaginyl Endopeptidase inhibitors
    J Biomol Struct Dyn1-19. PubMed  Europe PubMed DOI
  11. Wan,X.C., Zhang,Y.N., Zhang,H., Chen,Y., Cui,Z.H., Zhu,W.J. and Fang,G.M.
    Asparaginyl Endopeptidase-Mediated Peptide Cyclization for Phage Display
    Org Lett26, 2601-2605. PubMed  Europe PubMed DOI
  12. Xie,Y., Zhang,H. and Song,X.
    AEP promotes aberrant RNA splicing through DDX3X cleavage in solid tumors
    J Clin Invest134, PubMed  Europe PubMed DOI
  13. Xiong,M., Xia,D., Yu,H., Meng,L., Zhang,X., Chen,J., Tian,Y., Yuan,X., Niu,X., Nie,S., Zhang,Z., Liu,C., Chen,Q., Ye,K. and Zhang,Z.
    Microglia Process alpha-Synuclein Fibrils and Enhance their Pathogenicity in a TREM2-Dependent Manner
    Adv Sci (Weinh)e2413451-e2413451. PubMed  Europe PubMed DOI
  14. Zhang,X., Zou,L., Tang,L., Xiong,M., Yan,X.X., Meng,L., Chen,G., Xiong,J., Nie,S., Zhang,Z., Chen,Q. and Zhang,Z.
    Bridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice
    PLoS Biol22, e3002470-e3002470. PubMed  Europe PubMed DOI
  15. Zhou,L., Wu,J., Wei,Z. and Zheng,Y.
    Legumain in cardiovascular diseases
    Exp Biol Med (Maywood)249, 10121-10121. PubMed  Europe PubMed DOI  V
  16. Ziegler,A.R., Anderson,B.M., Latorre,R., McQuade,R.M., Dufour,A., Schmidt,B.L., Bunnett,N.W., Scott,N.E. and Edgington-Mitchell,L.E.
    N-terminomics profiling of naive and inflamed murine colon reveals proteolytic signatures of legumain
    J Cell Physiole31466-e31466. PubMed  Europe PubMed DOI
  17. Ziegler,A.R., Dufour,A., Scott,N.E. and Edgington-Mitchell,L.E.
    Ion Mobility-Based Enrichment-Free N-Terminomics Analysis Reveals Novel Legumain Substrates in Murine Spleen
    Mol Cell Proteomics23, 100714-100714. PubMed  Europe PubMed DOI
    18. 2023
  18. Jiang,Y., Li,L., Wu,R., Wu,L., Zhang,B., Wang,J.Z., Liu,R., Liu,F., Wang,J. and Wang,X.
    c-Src regulates delta-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6
    J Biol Chem299, 105462-105462. PubMed  Europe PubMed DOI  K
  19. Ke,B.Y., Qin,Y.S., Cheng,L. and Wang,S.Z.
    Legumain: a potential biomarker for atherosclerosis
    J Pharm Pharmacol75, 1395-1404. PubMed  Europe PubMed DOI  V
  20. Krummenacher,D., He,W., Kuhn,B., Schnider,C., Beurier,A., Brom,V., Sivasothy,T., Marty,C., Tosstorff,A., Hewings,D.S., Mesch,S., Pinard,E., Brandlin,M., Hochstrasser,R., Westwood,P., Rothe,J., Kronenberger,A., Morandi,F., Gutbier,S., Schuler,A., Heer,D., Gloria,L.E., Joedicke,L., Rudolph,M.G., Muller,L., Gruninger,F., Baumann,K., Kaniyappan,S., Manevski,N. and Bartels,B.
    Discovery of Orally Available and Brain Penetrant AEP Inhibitors
    J Med Chem66, 17026-17043. PubMed  Europe PubMed DOI
  21. Mitchell,J., Colon,B., Bayik,D. and Lathia,J.D.
    The missing link? LGMN connects hypoxia and immunosuppression in glioblastoma
    Cell Rep Med4, 101293-101293. PubMed  Europe PubMed DOI
  22. Qiu,Y., Lei,C., Zeng,J., Xie,Y., Cao,Y., Yuan,Q., Su,H., Zhang,Z. and Zhang,C.
    Asparagine endopeptidase protects podocytes in adriamycin-induced nephropathy by regulating actin dynamics through cleaving transgelin
    Mol Ther31, 3337-3354. PubMed  Europe PubMed DOI  K
  23. Wang,M., Tao,M., Zhu,W., Liu,W., Liu,Z. and Hai,Z.
    Tumor-Targeted Fluorescent/Photoacoustic Imaging of Legumain Activity In Vivo
    ACS Sens8, 4473-4477. PubMed  Europe PubMed DOI
  24. Zhang,W., Cao,L., Yang,J., Zhang,S., Zhao,J., Shi,Z., Liao,K., Wang,H., Chen,B., Qian,Z., Xu,H., Wu,L., Liu,H., Wang,H., Ma,C., Qiu,Y., Ge,J., Chen,J. and Lin,Y.
    AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments
    J Clin Invest134, PubMed  Europe PubMed DOI
    25. 2022
  25. Elamin,T., Santos,N.P., Briza,P., Brandstetter,H. and Dall,E.
    Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction
    J Biol Chem298, 102502-102502. PubMed  Europe PubMed DOI
  26. Jiang,S., Xiong,Y., Zhang,W., Zhu,J., Cheng,D., Gong,Y., Wu,Y., Qiao,H. and Fu,H.
    A Novel Legumain-Like Protease in Macrobrachium nipponense: Identification, Characterization, and Function Analysis in Ovary Maturation
    Front Endocrinol (Lausanne)13, 858726-858726. PubMed  Europe PubMed DOI
  27. Kovalyova,Y., Bak,D.W., Gordon,E.M., Fung,C., Shuman,J.H.B., Cover,T.L., Amieva,M.R., Weerapana,E. and Hatzios,S.K.
    An infection-induced oxidation site regulates legumain processing and tumor growth
    Nat Chem Biol18, 698-705. PubMed  Europe PubMed DOI
  28. Lu,C., Wang,X., Wang,Q., Zhang,L., Lin,J. and Qiu,L.
    Development of a Promising (18)F-Radiotracer for PET Imaging Legumain Activity In Vivo
    Pharmaceuticals (Basel)15, PubMed  Europe PubMed DOI
  29. Pan,L., Bai,P., Weng,X., Liu,J., Chen,Y., Chen,S., Ma,X., Hu,K., Sun,A. and Ge,J.
    Legumain Is an Endogenous Modulator of Integrin alphavbeta3 Triggering Vascular Degeneration, Dissection, and Rupture
    Circulation145, 659-674. PubMed  Europe PubMed DOI
  30. Zhang,D., Wang,Z., Hu,S., Chan,N.Y., Liew,H.T., Lescar,J., Tam,J.P. and Liu,C.F.
    Asparaginyl Endopeptidase-Mediated Protein C-Terminal Hydrazinolysis for the Synthesis of Bioconjugates
    Bioconjug Chem33, 238-247. PubMed  Europe PubMed DOI
    31. 2021
  31. Chen,C., Wang,D., Yu,Y., Zhao,T., Min,N., Wu,Y., Kang,L., Zhao,Y., Du,L., Zhang,M., Gong,J., Zhang,Z., Zhang,Y., Mi,X., Yue,S. and Tan,X.
    Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI
    Cell Death Dis12, 65-65. PubMed  Europe PubMed DOI  I
  32. Dall,E., Stanojlovic,V., Demir,F., Briza,P., Dahms,S.O., Huesgen,P.F., Cabrele,C. and Brandstetter,H.
    The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities
    ACS Catal11, 11885-11896. PubMed  Europe PubMed DOI
  33. Wu,Z., Xia,Y., Wang,Z., Su Kang,S., Lei,K., Liu,X., Jin,L., Wang,X., Cheng,L. and Ye,K.
    C/EBPbeta/delta-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of alpha-synuclein and MAOB
    Mol Psychiatry26, 568-585. PubMed  Europe PubMed DOI
  34. Xia,Y., Wang,Z.H., Zhang,Z., Liu,X., Yu,S.P., Wang,J.Z., Wang,X.C. and Ye,K.
    Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease
    Prog Neurobiol102113-102113. PubMed  Europe PubMed DOI
  35. Xia,Y., Wang,Z.H., Liu,P., Edgington-Mitchell,L., Liu,X., Wang,X.C. and Ye,K.
    TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies
    Mol Psychiatry26, 2943-2963. PubMed  Europe PubMed DOI
  36. Zhang,W. and Lin,Y.
    The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review
    Cells10, PubMed  Europe PubMed DOI  V
  37. Zhang,X., Tang,L. and Zhang,Z.
    ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase
    Biochem Biophys Res Commun537, 15-21. PubMed  Europe PubMed DOI
  38. Zou,L., Zhang,X., Xiong,M., Meng,L., Tian,Y., Pan,L., Yuan,X., Chen,G., Wang,Z., Bu,L., Yao,Z., Zhang,Z., Ye,K. and Zhang,Z.
    Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease
    Neurobiol Dis154, 105326-105326. PubMed  Europe PubMed DOI
    39. 2020
  39. Amarnath,S. and Brown,M.L.
    Harnessing proteases for T regulatory cell immunotherapy
    Eur J Immunol50, 770-778. PubMed  Europe PubMed DOI
  40. Chen,C., Ahn,E.H., Kang,S.S., Liu,X., Alam,A. and Ye,K.
    Gut dysbiosis contributes to amyloid pathology, associated with C/EBPbeta/AEP signaling activation in Alzheimer's disease mouse model
    Sci Adv6, eaba0466-eaba0466. PubMed  Europe PubMed DOI
  41. Chen,H.C., Rui,W., You,S.Y., Liu,X.W., Huang,J. and Chen,H.Y.
    Evaluation of the anti-cervical cancer effect of a prodrug CBZ-AAN-DOX with hypoxic cell culture and tumor-bearing zebrafish models
    Exp Cell Res111980-111980. PubMed  Europe PubMed DOI
  42. Chen,R., Zhang,Q., Yan,Y., Zhang,Y. and Zhang,T.
    Legumain Knockout Protects Against Abeta1-42-Induced AD-like Cognitive Deficits and Synaptic Plasticity Dysfunction Via Inhibiting Neuroinflammation Without Cleaving APP
    Mol Neurobiol PubMed  Europe PubMed DOI
  43. de Jager,S.C. and Hoefer,I.E.
    Legumain in cardiovascular disease: culprit or ally?
    Atherosclerosis296, 66-67. PubMed  Europe PubMed DOI
  44. English,A.W., Liu,X., Mistretta,O.C., Ward,P.J. and Ye,K.
    Asparagine endopeptidase (delta secretase), an enzyme implicated in Alzheimer's disease pathology, is an inhibitor of axon regeneration in peripheral nerves
    eNeuro PubMed  Europe PubMed DOI
  45. Hou,L., Yan,Y., Tian,C., Huang,Q., Fu,X., Zhang,Z., Zhang,H., Zhang,H. and Zhang,Z.
    Single-dose in situ storage for intensifying anticancer efficacy via combinatorial strategy
    J Control Release319, 438-449. PubMed  Europe PubMed DOI
  46. Kang,S.S., Liu,X., Ahn,E.H., Xiang,J., Manfredsson,F.P., Yang,X., Luo,H.R., Liles,L.C., Weinshenker,D. and Ye,K.
    Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus
    J Clin Invest130, 422-437. PubMed  Europe PubMed DOI
  47. Kang,S.S., Ahn,E.H. and Ye,K.
    Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease
    Exp Mol Med52, 1275-1287. PubMed  Europe PubMed DOI  V
  48. Kim,N. and Lee,H.J.
    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
    Biomed Res Int2020, 2010728-2010728. PubMed  Europe PubMed DOI  V
  49. Kremer,A.N., Bausenwein,J., Lurvink,E., Kremer,A.E., Rutten,C.E., van Bergen,C.A.M., Kretschmann,S., van der Meijden,E., Honders,M.W., Mazzeo,D., Watts,C., Mackensen,A., Falkenburg,J.H.F. and Griffioen,M.
    Discovery and differential processing of HLA class II-restricted minor histocompatibility antigen LB-PIP4K2A-1S and its allelic variant by asparagine endopeptidase
    Front Immunol11, 381-381. PubMed  Europe PubMed DOI  P
  50. Lerchen,H.G., Stelte-Ludwig,B., Sommer,A., Berndt,S., Rebstock,A.S., Johannes,S., Mahlert,C., Greven,S., Dietz,L. and Jorissen,H.
    Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads
    Bioconjug Chem PubMed  Europe PubMed DOI
  51. Li,X., Tang,M., Zhu,Q., Wang,X., Lin,Y. and Wang,X.
    The exosomal integrin alpha5beta1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration
    Cell Oncol (Dordr)43, 263-277. PubMed  Europe PubMed DOI
  52. Li,Y., Niu,Y., Zhu,J., Gao,C., Xu,Q., He,Z., Chen,D., Xu,M. and Liu,Y.
    Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release
    Nanoscale12, 2673-2685. PubMed  Europe PubMed DOI
  53. Liao,K., Qian,Z., Zhang,S., Chen,B., Li,Z., Huang,R., Cheng,L., Wang,T., Yang,R., Lan,J., Lu,X., Kong,L., Song,X., Qiu,Y. and Lin,Y.
    The LGMN pseudogene promotes tumor progression by acting as a miR-495-3p sponge in glioblastoma
    Cancer Lett490, 111-123. PubMed  Europe PubMed DOI
  54. Lin,Y., Liao,K., Miao,Y., Qian,Z., Fang,Z., Yang,X., Nie,Q., Jiang,G., Liu,J., Yu,Y., Wan,J., Zhang,X., Hu,Y., Jiang,J. and Qiu,Y.
    Role of asparagine endopeptidase in mediating wild-type p53 inactivation of glioblastoma
    J Natl Cancer Inst112, 343-355. PubMed  Europe PubMed DOI
  55. Liu,Y., Guo,C., Ding,Y., Long,X., Li,W., Ke,D., Wang,Q., Liu,R., Wang,J.Z., Zhang,H. and Wang,X.
    Blockage of AEP attenuates TBI-induced tau hyperphosphorylation and cognitive impairments in rats
    Aging (Albany NY)12, 19421-19439. PubMed  Europe PubMed DOI
  56. Lunde,N.N., Gregersen,I., Ueland,T., Shetelig,C., Holm,S., Kong,X.Y., Michelsen,A.E., Otterdal,K., Yndestad,A., Broch,K., Gullestad,L., Nyman,T.A., Bendz,B., Eritsland,J., Hoffmann,P., Skagen,K., Goncalves,I., Nilsson,J., Grenegard,M., Poreba,M., Drag,M., Seljeflot,I., Sporsheim,B., Espevik,T., Skjelland,M., Johansen,H.T., Solberg,R., Aukrust,P., Bjorkbacka,H., Andersen,G.O. and Halvorsen,B.
    Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
    Atherosclerosis296, 74-82. PubMed  Europe PubMed DOI
  57. Manfredi,J.J.
    Inactivation of wild-type p53 by asparagine endopeptidase in glioblastoma: an opportunity to target the "undruggable"
    J Natl Cancer Inst112, 327-329. PubMed  Europe PubMed DOI  T
  58. Reddy,B.D., Beeraka,N.M., Chitturi,C.M.K. and Madhunapantula,S.V.
    An Overview on Targeting Legumain for Inhibiting Cancers
    Curr Pharm Des PubMed  Europe PubMed DOI  K  V
  59. Ren,Y.C., Zhao,Q., He,Y., Li,B., Wu,Z., Dai,J., Wen,L., Wang,X. and Hu,G.
    Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor beta1
    J Mol Med (Berl) PubMed  Europe PubMed DOI  T  I
  60. Shen,L., Kang,L., Wang,D., Xun,J., Chen,C., Du,L., Zhang,M., Gong,J., Mi,X., Yue,S., Zhang,Y., Song,X., Xiang,R., Zhang,Z. and Tan,X.
    Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation
    Cancer Lett472, 40-49. PubMed  Europe PubMed DOI  K
  61. Soh,W.T., Demir,F., Dall,E., Perrar,A., Dahms,S.O., Kuppusamy,M., Brandstetter,H. and Huesgen,P.F.
    Extending proteome coverage with legumain as a highly specific digestion protease
    Anal Chem92, 2961-2971. PubMed  Europe PubMed DOI
  62. Umei,T.C., Kishimoto,Y., Aoyama,M., Saita,E., Niki,H., Ikegami,Y., Ohmori,R., Kondo,K. and Momiyama,Y.
    High plasma levels of legumain in patients with complex coronary lesions
    J Atheroscler Thromb27, 711-717. PubMed  Europe PubMed DOI
  63. Wang,H., Chen,B., Lin,Y., Zhou,Y. and Li,X.
    Legumain promotes gastric cancer progression through tumor-associated macrophages in vitro and in vivo
    Int J Biol Sci16, 172-180. PubMed  Europe PubMed DOI  K
  64. Wang,J., Wang,Y., Cao,H., Wang,H., Li,J., Li,Y., Li,Y. and Zhang,Z.
    Orally delivered legumain-activated nanovehicles improve tumor accumulation and penetration for combinational photothermal-chemotherapy
    J Control Release323, 59-70. PubMed  Europe PubMed DOI  U
  65. Wang,Y., Zhang,S., Wang,H., Cui,Y., Wang,Z., Cheng,X., Li,W., Hou,J., Ji,Y. and Liu,T.
    High Level of Legumain Was Correlated With Worse Prognosis and Peritoneal Metastasis in Gastric Cancer Patients
    Front Oncol10, 966-966. PubMed  Europe PubMed DOI
  66. Yu,T., Wan,F., Liu,C., Zhang,X., Liu,Z., Zhang,J., Xiong,J., Wang,T. and Zhang,Z.
    Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing alpha-synuclein aggregation and neuroinflammation
    Eur J Pharmacol888, 173586-173586. PubMed  Europe PubMed DOI
  67. Zhan,J., Zhong,J., Ma,S., Ma,W., Wang,Y., Yu,Z., Cai,Y. and Huang,W.
    Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth
    Chem Commun (Camb)56, 6957-6960. PubMed  Europe PubMed DOI
  68. Zhang,Z., Tian,Y. and Ye,K.
    delta-Secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities
    Transl Neurodegener9, 1-1. PubMed  Europe PubMed DOI
  69. Zhao,T., Zhou,H., Lei,L., Guo,C., Yang,Q., Gong,T., Sun,X., Song,X., Gong,T. and Zhang,Z.
    A new tandem peptide modified liposomal doxorubicin for tumor "ecological therapy"
    Nanoscale12, 3359-3369. PubMed  Europe PubMed DOI
    70. 2019
  70. Bai,P., Lyu,L., Yu,T., Zuo,C., Fu,J., He,Y., Wan,Q., Wan,N., Jia,D. and Lyu,A.
    Macrophage-derived legumain promotes pulmonary hypertension by activating the MMP (matrix metalloproteinase)-2/TGF (transforming growth factor)-beta1 signaling
    Arterioscler Thromb Vasc Biol39, e130-e130. PubMed  Europe PubMed DOI
  71. Behrendt,A., Bichmann,M., Ercan-Herbst,E., Haberkant,P., Schondorf,D.C., Wolf,M., Fahim,S.A., Murolo,E. and Ehrnhoefer,D.E.
    Asparagine endopeptidase cleaves tau at N167 after uptake into microglia
    Neurobiol Dis130, 104518-104518. PubMed  Europe PubMed DOI
  72. Chen,X., Wang,C., Liao,K., Zhou,S., Cao,L., Chen,J., Xu,C. and Lin,Y.
    USP17 suppresses tumorigenesis and tumor growth through deubiquitinating AEP
    Int J Biol Sci15, 738-748. PubMed  Europe PubMed DOI
  73. Eddie,S.L., Gregson,A., Graham,E., Burton,S., Harrison,T., Burden,R., Scott,C.J., Mullan,P.B. and Williams,R.
    Identification and SAR exploration of a novel series of legumain inhibitors
    Bioorg Med Chem Lett29, 1546-1548. PubMed  Europe PubMed DOI  I
  74. Fang,Y., Duan,C., Chen,S., Xie,P., Ai,W., Wang,L., Liu,R. and Fang,H.
    Increased legumain/Smad3 expression in atherosclerotic plaque of rat thoracic aorta
    Biomed Pharmacother119, 109353-109353. PubMed  Europe PubMed DOI
  75. Fuchigami,T., Itagaki,K., Ishikawa,N., Yoshida,S. and Nakayama,M.
    Synthesis and evaluation of radioactive/fluorescent peptide probes for imaging of legumain activity
    Bioorg Med Chem Lett126629-126629. PubMed  Europe PubMed DOI  L
  76. Kang,L., Shen,L., Lu,L., Wang,D., Zhao,Y., Chen,C., Du,L., Gong,J., Zhang,Y., Mi,X., Xiang,R., Zhang,M. and Tan,X.
    Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1
    Biochim Biophys Acta Mol Basis Dis1865, 2267-2275. PubMed  Europe PubMed DOI
  77. Lerchen,H.G., Stelte-Ludwig,B., Berndt,S., Sommer,A., Dietz,L., Rebstock,A.S., Johannes,S., Marx,L., Jorissen,H., Mahlert,C. and Greven,S.
    Antibody-prodrug conjugates with KSP inhibitors and legumain-mediated metabolite formation
    Chemistry25, 8208-8213. PubMed  Europe PubMed DOI
  78. Li,X., Liu,Q., Ye,S., Wang,S., Li,K., Lv,G., Peng,Y., Qiu,L. and Lin,J.
    A protease-responsive fluorescent probe for sensitive imaging of legumain activity in living tumor cells
    Chem Biol Drug Des94, 1494-1503. PubMed  Europe PubMed DOI  L
  79. Lunde,N.N., Bosnjak,T., Solberg,R. and Johansen,H.T.
    Mammalian legumain - a lysosomal cysteine protease with extracellular functions?
    Biochimie166, 77-83. PubMed  Europe PubMed DOI  V
  80. Ozawa,N., Sato,Y., Mori,Y., Masuda,H., Yamane,M., Yamamoto,Y., Shirai,R., Watanabe,R., Sato,K., Mori,Y., Hirano,T. and Watanabe,T.
    Legumain Promotes Atherosclerotic Vascular Remodeling
    Int J Mol Sci20, PubMed  Europe PubMed DOI
  81. Poreba,M.
    Recent advances in the development of legumain-selective chemical probes and peptide prodrugs
    Biol Chem400, 1529-1550. PubMed  Europe PubMed DOI  V  I
  82. Ruan,S., Xie,R., Qin,L., Yu,M., Xiao,W., Hu,C., Yu,W., Qian,Z., Ouyang,L., He,Q. and Gao,H.
    Aggregable nanoparticles-enabled chemotherapy and autophagy inhibition combined with anti-PD-L1 antibody for improved glioma treatment
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  83. Schlegel,K., Awwad,K., Heym,R.G., Holzinger,D., Doell,A., Barghorn,S., Jahn,T.R., Klein,C., Mordashova,Y., Schulz,M. and Gasparini,L.
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