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Literature for peptidase C02.002: calpain-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Binte Hanafi,Z., Mei,Y., Teo,H.Y., Zhu,Y., Yong Lionel,C.C., Chiu,J.W., Lu,J. and Liu,H.
    Calpain 2 regulates IL-1alpha secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment
    Oncoimmunology (2025) 14, 2451444-2451444. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Jeon,K.H., Park,S., Pak,E.S., Kim,J.A., Liu,Y., Hwang,S.Y., Na,Y. and Kwon,Y.
    Calpain 2 Isoform-Specific Cleavage of Filamin A Enhances HIF1alpha Nuclear Translocation, Promoting Metastasis in Triple-Negative Breast Cancer
    MedComm (2020) (2025) 6, e70147-e70147. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Teng,X., Wang,Y., Huang,H., Ding,Y., Wang,J., Liu,M., Song,K., Shao,L., Yu,Y., Yang,Z. and Shen,Z.
    Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
    Adv Sci (Weinh) (2025) , e2501112-e2501112. PubMed  Europe PubMed DOI
    4. 2024
  4. Baudry,M. and Bi,X.
    Revisiting the calpain hypothesis of learning and memory 40 years later
    Front Mol Neurosci (2024) 17, 1337850-1337850. PubMed  Europe PubMed DOI  PMC  EPMC  V
  5. Baudry,M., Wang,Y., Bi,X., Luo,Y.L., Wang,Z., Kamal,Z., Shirokov,A., Sullivan,E., Lagasca,D., Khalil,H., Lee,G., Fosnaugh,K., Bey,P., Mehdi,S. and Coulter,G.
    Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor
    Pharmacol Res Perspect (2024) 12, e1181-e1181. PubMed  Europe PubMed DOI  PMC  EPMC  I
  6. Ma,J., Kummarapurugu,A.B., Zheng,S., Ghio,A.J., Deshpande,L.S. and Voynow,J.A.
    Neutrophil Elastase Activates Macrophage Calpain as a Mechanism for Phagocytic Failure
    Am J Physiol Lung Cell Mol Physiol (2024) PubMed  Europe PubMed DOI
  7. Miyamoto,T., Kim,C., Chow,J., Dugas,J.C., DeGroot,J., Bagdasarian,A.L., Thottumkara,A.P., Larhammar,M., Calvert,M.E., Fox,B.M., Lewcock,J.W. and Kane,L.A.
    SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons
    J Biol Chem (2024) 300, 105630-105630. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Zhang,Y., Wei,S., Chen,Z., Xu,R., Li,S.R., You,L., Wu,R., Zhang,Y., Liao,J.Y., Xu,X., Song,E. and Luo,M.L.
    LncRNA FAISL Inhibits Calpain 2-Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer
    Adv Sci (Weinh) (2024) , e2407493-e2407493. PubMed  Europe PubMed DOI  K
    9. 2023
  9. Chang,Z., Niu,T., Shao,Q., Yue,J., Zhang,H., Tong,L., Gao,X. and Tang,B.
    Pt-Se-Bonded Nanoprobe for High-Fidelity Detection of Non-small Cell Lung Cancer and Enhancement of NIR II Photothermal Therapy
    Anal Chem (2023) 95, 18426-18435. PubMed  Europe PubMed DOI
  10. Chen,Y., Wang,P., Li,Q., Yan,X. and Xu,T.
    The protease calpain2a limits innate immunity by targeting TRAF6 in teleost fish
    Commun Biol (2023) 6, 355-355. PubMed  Europe PubMed DOI  PMC  EPMC  K
  11. Ojima,K., Hata,S., Shinkai-Ouchi,F., Ono,Y. and Muroya,S.
    Calpain-3 not only proteolyzes calpain-1 and -2 but also is a substrate for calpain-1 and -2
    J Biochem (2023) 174, 421-431. PubMed  Europe PubMed DOI
    12. 2022
  12. Bar,J., Popp,Y., Koudelka,T., Tholey,A. and Mikhaylova,M.
    Regulation of microtubule detyrosination by Ca2+ and conventional calpains
    J Cell Sci (2022) 135 PubMed  Europe PubMed DOI
  13. Rey,J., Breiden,M., Lux,V., Bluemke,A., Steindel,M., Ripkens,K., Mollers,B., Bravo Rodriguez,K., Boisguerin,P., Volkmer,R., Mieres-Perez,J., Clausen,T., Sanchez-Garcia,E. and Ehrmann,M.
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    Proc Natl Acad Sci U S A (2022) 119, e2113520119-e2113520119. PubMed  Europe PubMed DOI
    14. 2021
  14. Muniappan,L., Okuyama,M., Javidan,A., Thiagarajan,D., Jiang,W., Moorleghen,J.J., Yang,L., Balakrishnan,A., Howatt,D.A., Uchida,H.A., Saido,T.C. and Subramanian,V.
    Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice
    Arterioscler Thromb Vasc Biol (2021) 41, 1694-1709. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Tang,Y., Li,Y., Yu,G., Ling,Z., Zhong,K., Zilundu,P.L.M., Li,W., Fu,R. and Zhou,L.H.
    MicroRNA-137-3p Protects PC12 Cells Against Oxidative Stress by Downregulation of Calpain-2 and nNOS
    Cell Mol Neurobiol (2021) 41, 1373-1387. PubMed  Europe PubMed DOI
  16. Wang,J., Ciampa,G., Zheng,D., Shi,Q., Chen,B., Abel,E.D., Peng,T., Hall,D.D. and Song,L.S.
    Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy
    Biochem J (2021) 478, 3539-3553. PubMed  Europe PubMed DOI
    17. 2020
  17. Chen,Y., Chen,L., Hong,D., Chen,Z., Zhang,J., Fu,L., Pan,D., Zhang,Y., Xu,Y., Gan,S., Xiao,C., Tao,L. and Shen,X.
    Correction: Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2
    Cell Death Dis (2020) 11, 532-532. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Cicognola,C., Satir,T.M., Brinkmalm,G., Matecko-Burmann,I., Agholme,L., Bergstrom,P., Becker,B., Zetterberg,H., Blennow,K. and Hoglund,K.
    Tauopathy-associated tau fragment ending at amino acid 224 is generated by calpain-2 cleavage
    J Alzheimers Dis (2020) 74, 1143-1156. PubMed  Europe PubMed DOI  A
  19. Dewitt,S. and Hallett,M.B.
    Calpain activation by Ca(2+) and its role in phagocytosis
    Adv Exp Med Biol (2020) 1246, 129-151. PubMed  Europe PubMed DOI
  20. Donkor,I.O., Xu,J., Liu,J. and Cameron,K.
    Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors
    Bioorg Med Chem (2020) , 115433-115433. PubMed  Europe PubMed DOI  I
  21. Goto,S., Ozaki,Y., Ozawa,F., Mizutani,E., Kitaori,T., Suzumori,N., Blomgren,K., Furuno,T. and Sugiura-Ogasawara,M.
    The investigation of calpain in human placenta with fetal growth restriction
    Am J Reprod Immunol (2020) , e13325-e13325. PubMed  Europe PubMed DOI
  22. Ko,Y.U., Song,H.Y., Kim,W.K., Yune,T.Y., Yun,N. and Oh,Y.J.
    Calpain-mediated cleavage of Fbxw7 during excitotoxicity
    Neurosci Lett (2020) 736, 135265-135265. PubMed  Europe PubMed DOI  I
  23. Kwon,S.H., Wi,T., Park,Y.I., Kim,M.W., Lee,G., Higaki,T., Choi,J.H. and Lee,R.
    Noninvasive early detection of calpain 2-enriched non-small cell lung cancer using a human serum albumin-bounded calpain 2 nanosensor
    Bioconjug Chem (2020) 31, 803-812. PubMed  Europe PubMed DOI  L
  24. Lahiri,S.K., Quick,A.P., Samson-Couterie,B., Hulsurkar,M., Elzenaar,I., van Oort,R.J. and Wehrens,X.H.T.
    Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling
    Basic Res Cardiol (2020) 115, 49-49. PubMed  Europe PubMed DOI
  25. Li,Y., He,Z., Lv,H., Chen,W. and Chen,J.
    Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-alpha-induced autophagy in mouse hippocampal neurons
    J Cell Mol Med (2020) PubMed  Europe PubMed DOI  PMC  EPMC
  26. Padmanabha,S. and Vallikannan,B.
    Fatty acids influence the efficacy of lutein in the modulation of alpha-crystallin chaperone function: Evidence from selenite induced cataract rat model
    Biochem Biophys Res Commun (2020) 529, 425-431. PubMed  Europe PubMed DOI
  27. Panico,P., Hiriart,M., Ostrosky-Wegman,P. and Salazar,A.M.
    TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes
    J Mol Endocrinol (2020) 65, 45-57. PubMed  Europe PubMed DOI
  28. Wang,Y., Liu,Y., Bi,X. and Baudry,M.
    Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death
    Cells (2020) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  29. Yi,C., Wu,W., Zheng,D., Peng,G., Huang,H., Shen,Z. and Teng,X.
    Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis
    Cell Death Dis (2020) 11, 533-533. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Zu,S.Q., Feng,Y.B., Zhu,C.J., Wu,X.S., Zhou,R.P., Li,G., Dai,B.B., Wang,Z.S., Xie,Y.Y., Li,Y., Ge,J.F. and Chen,F.H.
    Acid-sensing ion channel 1a mediates acid-induced pyroptosis through calpain-2/calcineurin pathway in rat articular chondrocytes
    Cell Biol Int (2020) 44, 2140-2152. PubMed  Europe PubMed DOI
    31. 2019
  31. Antoniades,I., Charalambous,A., Christodoulou,N., Zanardelli,S. and Skourides,P.A.
    Methods of calpain inhibition to determine the role of calpains in embryo development in amphibians
    Methods Mol Biol (2019) 1915, 249-259. PubMed  Europe PubMed DOI
  32. Baudry,M.
    Calpain-1 and calpain-2 in the brain: Dr. Jekill and Mr Hyde?
    Curr Neuropharmacol (2019) 17, 823-829. PubMed  Europe PubMed DOI
  33. Biswas,A.K. and Tandon,S.
    Casein zymography for analysis of calpain-1 and calpain-2 activity
    Methods Mol Biol (2019) 1915, 31-38. PubMed  Europe PubMed DOI
  34. Biswas,A.K. and Tandon,S.
    Single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography
    Methods Mol Biol (2019) 1915, 3-11. PubMed  Europe PubMed DOI
  35. Del Carmen Lafita-Navarro,M. and Conacci-Sorrell,M.
    Identification of calpain-activated protein functions
    Methods Mol Biol (2019) 1915, 149-160. PubMed  Europe PubMed DOI
  36. Duverle,D.A. and Mamitsuka,H.
    CalCleaveMKL: a tool for calpain cleavage prediction
    Methods Mol Biol (2019) 1915, 121-147. PubMed  Europe PubMed DOI
  37. Gao,Y., Hall,C., MacLeod,J. and Greer,P.A.
    Genetic models of calpain deficiency and ectopic expression
    Methods Mol Biol (2019) 1915, 261-274. PubMed  Europe PubMed DOI  K
  38. Kitagawa,S.
    Experimental manipulation of calpain activity in vitro
    Methods Mol Biol (2019) 1915, 209-218. PubMed  Europe PubMed DOI  I
  39. Liu,Z.F., Ji,J.J., Zheng,D., Su,L. and Peng,T.
    Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation
    J Cell Physiol (2019) 234, 10761-10770. PubMed  Europe PubMed DOI
  40. Liu,Z.X., Yu,K., Dong,J., Zhao,L., Liu,Z., Zhang,Q., Li,S., Du,Y. and Cheng,H.
    Precise prediction of calpain cleavage sites and their aberrance caused by mutations in cancer
    Front Genet (2019) 10, 715-715. PubMed  Europe PubMed DOI  PMC  EPMC  P
  41. McCartney,C.E. and Davies,P.L.
    Bacterial expression and purification of calpains
    Methods Mol Biol (2019) 1915, 13-27. PubMed  Europe PubMed DOI  E
    42. 2018
  42. Ahmad,F., Das,D., Kommaddi,R.P., Diwakar,L., Gowaikar,R., Rupanagudi,K.V., Bennett,D.A. and Ravindranath,V.
    Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects
    Sci Rep (2018) 8, 13119-13119. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Gao,X., Mao,Y.H., Xiao,C., Li,K., Liu,W., Li,L.Y. and Pang,J.
    Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-kappaB/DNMT1 signaling pathway
    Prostate (2018) 78, 682-690. PubMed  Europe PubMed DOI
  44. Kling,A., Jantos,K., Mack,H., Hornberger,W., Backfisch,G., Lao,Y., Nijsen,M., Rendenbach-Mueller,B. and Moeller,A.
    Mitigating the metabolic liability of carbonyl reduction: novel calpain inhibitors with P1' extension
    ACS Med Chem Lett (2018) 9, 221-226. PubMed  Europe PubMed DOI  PMC  EPMC  I
  45. MacLeod,J.A., Gao,Y., Hall,C., Muller,W.J., Gujral,T.S. and Greer,P.A.
    Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib
    Oncotarget (2018) 9, 33382-33395. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  46. McCartney,C.E., Ye,Q., Campbell,R.L. and Davies,P.L.
    Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide
    J Biol Chem (2018) 293, 17716-17730. PubMed  Europe PubMed DOI
  47. Nguyen,H.H., Volkov,A.N., Vandenbussche,G., Tompa,P. and Pauwels,K.
    In vivo biotinylated calpastatin improves the affinity purification of human m-calpain
    Protein Expr Purif (2018) 145, 77-84. PubMed  Europe PubMed DOI
  48. Schwartz,A.D., Hall,C.L., Barney,L.E., Babbitt,C.C. and Peyton,S.R.
    Integrin alpha6 and EGFR signaling converge at mechanosensitive calpain 2
    Biomaterials (2018) 178, 73-82. PubMed  Europe PubMed DOI
  49. Wang,Y., Bi,X. and Baudry,M.
    Calpain-2 as a therapeutic target for acute neuronal injury
    Expert Opin Ther Targets (2018) 22, 19-29. PubMed  Europe PubMed DOI  V  T
  50. Wang,Y., Liu,Y., Lopez,D., Lee,M., Dayal,S., Hurtado,A., Bi,X. and Baudry,M.
    Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice
    J Neurotrauma (2018) 35, 105-117. PubMed  Europe PubMed DOI  I
  51. Zhang,G., Fang,T., Chang,M., Li,J., Hong,Q., Bai,C. and Zhou,J.
    Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling
    Oncol Rep (2018) 40, 1937-1946. PubMed  Europe PubMed DOI  K
    52. 2017
  52. McCartney,C.E., MacLeod,J.A., Greer,P.A. and Davies,P.L.
    An easy-to-use FRET protein substrate to detect calpain cleavage in vitro and in vivo
    Biochim Biophys Acta (2017) 1865, 221-230. PubMed  Europe PubMed DOI  A
  53. Montgomery,D.S., Yu,L., Ghazi,Z.M., Thai,T.L., Al-Khalili,O., Ma,H.P., Eaton,D.C. and Alli,A.A.
    ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins
    Am J Physiol Cell Physiol (2017) 313, C42-C53. PubMed  Europe PubMed DOI
  54. Nagayoshi,T., Isoda,K., Mamiya,N. and Kida,S.
    Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory
    Mol Brain (2017) 10, 61-61. PubMed  Europe PubMed DOI  PMC  EPMC  I
  55. Nguyen,H.H., Varadi,M., Tompa,P. and Pauwels,K.
    Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin
    PLoS ONE (2017) 12, e0174125-e0174125. PubMed  Europe PubMed DOI
  56. Plantier,V. and Brocard,F.
    [Calpain as a new therapeutic target for treating spasticity after a spinal cord injury]
    Med Sci (Paris) (2017) 33, 629-636. PubMed  Europe PubMed DOI  T
  57. Wang,Y., Hall,R.A., Lee,M., Kamgar-Parsi,A., Bi,X. and Baudry,M.
    The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation
    Sci Rep (2017) 7, 11771-11771. PubMed  Europe PubMed DOI  PMC  EPMC
    58. 2016
  58. Abeyrathna,P., Kovacs,L., Han,W. and Su,Y.
    Calpain-2 activates Akt via TGF-beta1-mTORC2 pathway in pulmonary artery smooth muscle cells
    Am J Physiol Cell Physiol (2016) 311, C24-C34. PubMed  Europe PubMed DOI  I
  59. Baek,K.H., Yu,H.V., Kim,E., Na,Y. and Kwon,Y.
    Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway
    Oncotarget (2016) 7, 30831-30844. PubMed  Europe PubMed DOI
  60. Baudry,M. and Bi,X.
    Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration
    Trends Neurosci (2016) 39, 235-245. PubMed  Europe PubMed DOI
  61. Blanc,F., Furio,L., Moisy,D., Yen,H.L., Chignard,M., Letavernier,E., Naffakh,N., Mok,C.K. and Si-Tahar,M.
    Targeting host calpain proteases decreases influenza A virus infection
    Am J Physiol Lung Cell Mol Physiol (2016) 310, L689-L699. PubMed  Europe PubMed DOI
  62. Hudson,I.L., Leemaqz,S.Y., Neffe,A.T. and Abell,A.D.
    Classifying calpain inhibitors for the treatment of cataracts: A self organising map (SOM) ANN/KM approach in drug discovery
    Stud Comput Intell (2016) 628, 161-212. DOI  I
  63. Ji,J., Su,L. and Liu,Z.
    Critical role of calpain in inflammation
    Biomed Rep (2016) 5, 647-652. PubMed  Europe PubMed DOI  PMC  EPMC  V
  64. Liu,Y., Wang,Y., Zhu,G., Sun,J., Bi,X. and Baudry,M.
    A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation
    Neuropharmacology (2016) 105, 471-477. PubMed  Europe PubMed DOI  I
  65. Low,K.E., Ler,S., Chen,K.J., Campbell,R.L., Hickey,J.L., Tan,J., Scully,C.C., Davies,P.L., Yudin,A.K. and Zaretsky,S.
    Rational design of calpain inhibitors based on calpastatin peptidomimetics
    J Med Chem (2016) 59, 5403-5415. PubMed  Europe PubMed DOI  I
  66. Seinfeld,J., Baudry,N., Xu,X., Bi,X. and Baudry,M.
    Differential activation of calpain-1 and calpain-2 following kainate-induced seizure activity in rats and mice
    eNeuro (2016) 3 PubMed  Europe PubMed DOI  PMC  EPMC
  67. Shinkai-Ouchi,F., Koyama,S., Ono,Y., Hata,S., Ojima,K., Shindo,M., duVerle,D., Ueno,M., Kitamura,F., Doi,N., Takigawa,I., Mamitsuka,H. and Sorimachi,H.
    Predictions of cleavability of calpain proteolysis by quantitative structure-activity relationship analysis using newly determined cleavage sites and catalytic efficiencies of an oligopeptide array
    Mol Cell Proteomics (2016) 15, 1262-1280. PubMed  Europe PubMed DOI  P
  68. Wang,Y., Lopez,D., Davey,P.G., Cameron,D.J., Nguyen,K., Tran,J., Marquez,E., Liu,Y., Bi,X. and Baudry,M.
    Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury
    Neurobiol Dis (2016) 93, 121-128. PubMed  Europe PubMed DOI  I
  69. Yuasa,T., Amo-Shiinoki,K., Ishikura,S., Takahara,M., Matsuoka,T., Kaneto,H., Kuroda,A., Matsuhisa,M. and Hashida,S.
    Sequential cleavage of insulin receptor by calpain 2 and gamma-secretase impairs insulin signalling
    Diabetologia (2016) 59, 2711-2721. PubMed  Europe PubMed DOI
    70. 2015
  70. Cagmat,E.B., Guingab-Cagmat,J.D., Vakulenko,V., Hayes,R.L. and Anagli,J.
    Potential use of calpain inhibitors as brain injury therapy
     (2015) PubMed  Europe PubMed  I
  71. Donkor,I.O.
    An updated patent review of calpain inhibitors (2012 - 2014)
    Expert Opin Ther Pat (2015) 25, 17-31. PubMed  Europe PubMed DOI  I
  72. Lei,H.Y., Zhou,X.L., Ruan,Z.R., Sun,W.C., Eriani,G. and Wang,E.D.
    Calpain cleaves most components in the multiple aminoacyl-tRNA synthetase complex and affects their functions
    J Biol Chem (2015) 290, 26314-26327. PubMed  Europe PubMed DOI
  73. Li,F.Z., Cai,P.C., Song,L.J., Zhou,L.L., Zhang,Q., Rao,S.S., Xia,Y., Xiang,F., Xin,J.B., Greer,P.A., Shi,H.Z., Su,Y., Ma,W.L. and Ye,H.
    Crosstalk between calpain activation and TGF-beta1 augments collagen-I synthesis in pulmonary fibrosis
    Biochim Biophys Acta (2015) 1852, 1796-1804. PubMed  Europe PubMed DOI  K
  74. Menzies,F.M., Garcia-Arencibia,M., Imarisio,S., O'Sullivan,N.C., Ricketts,T., Kent,B.A., Rao,M.V., Lam,W., Green-Thompson,Z.W., Nixon,R.A., Saksida,L.M., Bussey,T.J., O'Kane,C.J. and Rubinsztein,D.C.
    Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity
    Cell Death Differ (2015) 22, 433-444. PubMed  Europe PubMed DOI
  75. Rose,A.H., Huang,Z., Mafnas,C., Hara,J.H., Hoffmann,F.W., Hashimoto,A.S., Bertino,P. and Hoffmann,P.R.
    Calpain-2 inhibitor therapy reduces murine colitis and colitis-associated cancer
    Inflamm Bowel Dis (2015) 21, 2005-2015. PubMed  Europe PubMed DOI  I
  76. Shintani-Ishida,K. and Yoshida,K.I.
    Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia-reperfusion
    Int J Cardiol (2015) 197, 26-32. PubMed  Europe PubMed DOI
    77. 2014
  77. Borras,T.
    The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review
    J Ocul Pharmacol Ther (2014) 30, 202-212. PubMed  Europe PubMed DOI
  78. Gokhin,D.S., Tierney,M.T., Sui,Z., Sacco,A. and Fowler,V.M.
    Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle
    Mol Biol Cell (2014) 25, 852-865. PubMed  Europe PubMed DOI
  79. Jones,S.A., Duncan,J., Aitken,S.G., Coxon,J.M. and Abell,A.D.
    The preparation of macrocyclic calpain inhibitors by ring closing metathesis and cross metathesis
    Aust J Chem (2014) 67, 1257-1263. DOI  I
  80. Kaneko,Y., Murphy,C.R. and Day,M.L.
    Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites
    Histochem Cell Biol (2014) 141, 423-430. PubMed  Europe PubMed DOI  I
  81. Kanzaki,K., Kuratani,M., Matsunaga,S., Yanaka,N. and Wada,M.
    Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions
    J Muscle Res Cell Motil (2014) 35, 179-189. PubMed  Europe PubMed DOI
  82. Kim,H., Kang,A.-Y., Ko,A.-R., Park,H.C., So,I., Park,J.H., Cheong,H.I., Hwang,Y.-H. and Ahn,C.
    Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations
    Exp Cell Res (2014) 320, 62-68. PubMed  Europe PubMed DOI
  83. Low,K.E., Karunan Partha,S., Davies,P.L. and Campbell,R.L.
    Allosteric inhibitors of calpains: reevaluating inhibition by PD150606 and LSEAL
    Biochim Biophys Acta (2014) 1840, 3367-3373. PubMed  Europe PubMed DOI  I
  84. Lu,S., Kanekura,K., Hara,T., Mahadevan,J., Spears,L.D., Oslowski,C.M., Martinez,R., Yamazaki-Inoue,M., Toyoda,M., Neilson,A., Blanner,P., Brown,C.M., Semenkovich,C.F., Marshall,B.A., Hershey,T., Umezawa,A., Greer,P.A. and Urano,F.
    A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome
    Proc Natl Acad Sci U S A (2014) 111, E5292-E5301. PubMed  Europe PubMed DOI  T
  85. Nakajima,T., Shearer,T.R. and Azuma,M.
    Loss of calpastatin leads to activation of calpain in human lens epithelial cells
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  86. Pawlinski,R.
    Inhibit the calpain to climb the mountain
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  87. Piatkov,K.I., Oh,J.H., Liu,Y. and Varshavsky,A.
    Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway
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  88. Tyagi,T., Ahmad,S., Gupta,N., Sahu,A., Ahmad,Y., Nair,V., Chatterjee,T., Bajaj,N., Sengupta,S., Ganju,L., Singh,S.B. and Ashraf,M.Z.
    Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype
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  89. Yamashita,T. and Kwak,S.
    [Calpain plays a crucial role in TDP-43 pathology]
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    90. 2013
  90. Amini,M., Ma,C.L., Farazifard,R., Zhu,G., Zhang,Y., Vanderluit,J., Zoltewicz,J.S., Hage,F., Savitt,J.M., Lagace,D.C., Slack,R.S., Beique,J.C., Baudry,M., Greer,P.A., Bergeron,R. and Park,D.S.
    Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury
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  91. Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y.
    Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors
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  92. Banoczi,Z., Tantos,A., Farkas,A., Majer,Z., Dokus,L.E., Tompa,P. and Hudecz,F.
    New m-calpain substrate-based azapeptide inhibitors
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  93. Baudry,M., Chou,M.M. and Bi,X.
    Targeting calpain in synaptic plasticity
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  94. Bhatti,G., Jayanthi,L., Vandevord,P. and Gebremichael,Y.
    Computational investigation of the key factors affecting the second stage activation mechanisms of domain II m-calpain
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  95. Briz,V., Hsu,Y.T., Li,Y., Lee,E., Bi,X. and Baudry,M.
    Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis
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  96. Clinkinbeard,T., Ghoshal,S., Craddock,S., Creed Pettigrew,L. and Guttmann,R.P.
    Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion
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  97. Elagib,K.E., Rubinstein,J.D., Delehanty,L.L., Ngoh,V.S., Greer,P.A., Li,S., Lee,J.K., Li,Z., Orkin,S.H., Mihaylov,I.S. and Goldfarb,A.N.
    Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation
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  98. Gao,W., Liu,J., Hu,M., Huang,M., Cai,S., Zeng,Z., Lin,B., Cao,X., Chen,J., Zeng,J.Z., Zhou,H. and Zhang,X.K.
    Regulation of proteolytic cleavage of retinoid X receptor-alpha by GSK-3beta
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  99. Hubener,J., Weber,J.J., Richter,C., Honold,L., Weiss,A., Murad,F., Breuer,P., Wullner,U., Bellstedt,P., Paquet-Durand,F., Takano,J., Saido,T.C., Riess,O. and Nguyen,H.P.
    Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3)
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  100. Jones,S.A., Neilsen,P.M., Siew,L., Callen,D.F., Goldfarb,N.E., Dunn,B.M. and Abell,A.D.
    A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease
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  101. Saraiva,N., Prole,D.L., Carrara,G., Johnson,B.F., Taylor,C.W., Parsons,M. and Smith,G.L.
    hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2
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  102. Shao,H., Travers,T., Camacho,C.J. and Wells,A.
    The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading
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  103. Subramanian,V., Moorleghen,J.J., Balakrishnan,A., Howatt,D.A., Chishti,A.H. and Uchida,H.A.
    Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice
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  104. Uribe,K.B., Etxebarria,A., Martin,C. and Ostolaza,H.
    Calpain-mediated processing of adenylate cyclase toxin generates a cytosolic soluble catalytically active N-terminal domain
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  105. Wang,C.Y., Xie,J.W., Wang,T., Xu,Y., Cai,J.H., Wang,X., Zhao,B.L., An,L. and Wang,Z.Y.
    Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease
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  106. Wang,Y., Briz,V., Chishti,A., Bi,X. and Baudry,M.
    Distinct roles for mu-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration
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  107. Zanardelli,S., Christodoulou,N. and Skourides,P.A.
    Calpain2 protease: A new member of the Wnt/Ca(2+) pathway modulating convergent extension movements in Xenopus
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    108. 2012
  108. Campbell,R.L. and Davies,P.L.
    Structure-function relationships in calpains
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  109. Chen,H., Jiao,W., Jones,M.A., Coxon,J.M., Morton,J.D., Bickerstaffe,R., Pehere,A.D., Zvarec,O. and Abell,A.D.
    New tripeptide-based macrocyclic calpain inhibitors formed by N-alkylation of histidine
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  110. Hata,S., Ueno,M., Kitamura,F. and Sorimachi,H.
    Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature
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  111. Kawashima,I., Liu,Z., Mullany,L.K., Mihara,T., Richards,J.S. and Shimada,M.
    EGF-Like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement
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  112. Lal,S., La Du,J., Tanguay,R.L. and Greenwood,J.A.
    Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment
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  113. Santos,D.M., Xavier,J.M., Morgado,A.L., Sola,S. and Rodrigues,C.M.
    Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation
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  114. Shen,C., Yu,Y., Li,H., Yan,G., Liu,M., Shen,H. and Yang,P.
    Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network
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    Calpain-2/m-calpain
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    Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons
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    117. 2011
  117. Bozoky,Z., Rona,G., Klement,E., Medzihradszky,K.F., Merenyi,G., Vertessy,B.G. and Friedrich,P.
    Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide
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  118. Caberoy,N.B., Alvarado,G. and Li,W.
    Identification of calpain substrates by ORF phage display
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  119. Chou,J.S., Impens,F., Gevaert,K. and Davies,P.L.
    m-Calpain activation in vitro does not require autolysis or subunit dissociation
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  120. Donkor,I.O.
    Calpain inhibitors: a survey of compounds reported in the patent and scientific literature
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  121. Huang,Z., Hoffmann,F.W., Norton,R.L., Hashimoto,A.C. and Hoffmann,P.R.
    Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages
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  122. Khan,J., Davy,C.E., McIntosh,P.B., Jackson,D.J., Hinz,S., Wang,Q. and Doorbar,J.
    Role of calpain in the formation of human papillomavirus type 16 E1^E4 amyloid fibers and reorganization of the keratin network
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  123. Liu,Z., Cao,J., Gao,X., Ma,Q., Ren,J. and Xue,Y.
    GPS-CCD: a novel computational program for the prediction of calpain cleavage sites
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  124. Taneike,M., Mizote,I., Morita,T., Watanabe,T., Hikoso,S., Yamaguchi,O., Takeda,T., Oka,T., Tamai,T., Oyabu,J., Murakawa,T., Nakayama,H., Nishida,K., Takeda,J., Mochizuki,N., Komuro,I. and Otsu,K.
    Calpain protects the heart from hemodynamic stress
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    125. 2010
  125. Aroca-Aguilar,J.D., Martinez-Redondo,F., Sanchez-Sanchez,F., Coca-Prados,M. and Escribano,J.
    Functional role of proteolytic processing of recombinant myocilin in self-aggregation
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  126. Chakrabarti,S., Rizvi,M., Morin,K., Garg,R. and Freedman,J.E.
    The role of CD40L and VEGF in the modulation of angiogenesis and inflammation
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  127. Chan,K.T., Bennin,D.A. and Huttenlocher,A.
    Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK)
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  128. Farr,C. and Berger,S.
    Measuring calpain activity in fixed and living cells by flow cytometry
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  129. Huang,C.J., Gurlo,T., Haataja,L., Costes,S., Daval,M., Ryazantsev,S., Wu,X., Butler,A.E. and Butler,P.C.
    Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes
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  130. Jang,H.S., Lal,S. and Greenwood,J.A.
    Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2
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  131. Kar,P., Samanta,K., Shaikh,S., Chowdhury,A., Chakraborti,T. and Chakraborti,S.
    Mitochondrial calpain system: an overview
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  132. Leloup,L., Shao,H., Bae,Y.H., Deasy,B., Stolz,D., Roy,P. and Wells,A.
    m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate
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  133. Magnaghi-Jaulin,L., Marcilhac,A., Rossel,M., Jaulin,C., Benyamin,Y. and Raynaud,F.
    Calpain 2 is required for sister chromatid cohesion
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  134. Ovat,A., Li,Z.Z., Hampton,C.Y., Asress,S.A., Fernandez,F.M., Glass,J.D. and Powers,J.C.
    Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors
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  135. Samanta,K., Kar,P., Chakraborti,T., Shaikh,S. and Chakraborti,S.
    Characteristic properties of endoplasmic reticulum membrane m-calpain, calpastatin and lumen m-calpain: a comparative study between membrane and lumen m-calpains
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  136. Svensson,L., McDowall,A., Giles,K.M., Stanley,P., Feske,S. and Hogg,N.
    Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes
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  137. Wells,A. and Leloup,L.
    Calpain
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    Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors
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  139. Bevers,M.B., Lawrence,E., Maronski,M., Starr,N., Amesquita,M. and Neumar,R.W.
    Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity
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  140. Camins,A., Crespo-Biel,N., Junyent,F., Verdaguer,E., Canudas,A.M. and Pallas,M.
    Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium
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  141. Doshi,S. and Lynch,D.R.
    Calpain and the glutamatergic synapse
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  142. Guyton,M.K., Brahmachari,S., Das,A., Samantaray,S., Inoue,J., Azuma,M., Ray,S.K. and Banik,N.L.
    Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells
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  143. Hayakawa,M., Hayakawa,H., Matsuyama,Y., Tamemoto,H., Okazaki,H. and Tominaga,S.
    Mature interleukin-33 is produced by calpain-mediated cleavage in vivo
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  144. Janssens,V., Derua,R., Zwaenepoel,K., Waelkens,E. and Goris,J.
    Specific regulation of protein phosphatase 2A PR72/B'' subunits by calpain
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  145. Jones,S.A., Jones,M.A., McNabb,S.B., Aitken,S.G., Coxon,J.M. and Abell,A.D.
    N-heterocyclic dipeptide aldehyde calpain inhibitors
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  146. Kelly,J.C., Cuerrier,D., Graham,L.A., Campbell,R.L. and Davies,P.L.
    Profiling of calpain activity with a series of FRET-based substrates
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    Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases
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  148. Ozaki,T., Yamashita,T. and Ishiguro,S.
    Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria
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  149. Ravulapalli,R., Campbell,R.L., Gauthier,S.Y., Dhe-Paganon,S. and Davies,P.L.
    Distinguishing between calpain heterodimerization and homodimerization
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  150. Wang,H.C., Huang,Y.S., Ho,C.C., Jeng,J.C. and Shih,H.M.
    SUMO modification modulates the activity of calpain-2
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    151. 2008
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    Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion
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  152. Croall,D.E., Vanhooser,L.M. and Cashon,R.E.
    Detecting the active conformation of calpain with calpastatin-based reagents
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  153. Hanna,R.A., Campbell,R.L. and Davies,P.L.
    Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
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  154. Honda,M., Masui,F., Kanzawa,N., Tsuchiya,T. and Toyo-oka,T.
    Specific knockdown of m-calpain blocks myogenesis with cDNA deduced from the corresponding RNAi
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  155. Jones,M.A., Morton,J.D., Coxon,J.M., McNabb,S.B., Lee,H.Y., Aitken,S.G., Mehrtens,J.M., Robertson,L.J., Neffe,A.T., Miyamoto,S., Bickerstaffe,R., Gately,K., Wood,J.M. and Abell,A.D.
    Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors
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  156. Lee,H.Y., Morton,J.D., Robertson,L.J., McDermott,J.D., Bickerstaffe,R., Abell,A.D., Jones,M.A., Mehrtens,J.M. and Coxon,J.M.
    Evaluation of a novel calpain inhibitor as a treatment for cataract
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  157. Lepage,S.E. and Bruce,A.E.
    Characterization and comparative expression of zebrafish calpain system genes during early development
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    Calpain in the CNS: from synaptic function to neurotoxicity
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    Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains
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  160. Nam,D.H., Lee,K.S., Kim,S.H., Kim,S.M., Jung,S.Y., Chung,S.H., Kim,H.J., Kim,N.D., Jin,C. and Lee,Y.S.
    Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors
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  161. Sprague,C.R., Fraley,T.S., Jang,H.S., Lal,S. and Greenwood,J.A.
    Phosphoinositide binding to the substrate regulates susceptibility to proteolysis by calpain
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  162. Upla,P., Marjomaki,V., Nissinen,L., Nylund,C., Waris,M., Hyypia,T. and Heino,J.
    Calpain 1 and 2 are required for RNA replication of echovirus 1
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    163. 2007
  163. Abell,A.D., Jones,M.A., Neffe,A.T., Aitken,S.G., Cain,T.P., Payne,R.J., McNabb,S.B., Coxon,J.M., Stuart,B.G., Pearson,D., Lee,H.Y. and Morton,J.D.
    Investigation into the P3 binding domain of m-calpain using photoswitchable diazo- and triazene-dipeptide aldehydes: new anticataract agents
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  164. [YEAR:17-1-2007]Banoczi,Z., Tantos,A., Farkas,A., Tompa,P., Friedrich,P. and Hudecz,F.
    Synthesis of cell-penetrating conjugates of calpain activator peptides
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  165. Berg,U., Bang,P. and Carlsson-Skwirut,C.
    Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1
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  166. Bolshakov,V.Y.
    SCOPing out proteases in long-term memory
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    Development of calpain-specific inactivators by screening of positional scanning epoxide libraries
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  168. Goudenege,S., Dargelos,E., Claverol,S., Bonneu,M., Cottin,P. and Poussard,S.
    Comparative proteomic analysis of myotube caveolae after milli-calpain deregulation
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    Calpain is required for the rapid, calcium-dependent repair of wounded plasma membrane
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  170. Mellgren,R.L. and Huang,X.
    Fetuin A stabilizes m-calpain and facilitates plasma membrane repair
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  171. Saito,M., Li,H., Thompson,V.F., Kunisaki,N. and Goll,D.E.
    Purification and characterization of calpain and calpastatin from rainbow trout, Oncorhynchus mykiss
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    Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease
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