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Literature for peptidase C02.002: calpain-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Binte Hanafi,Z., Mei,Y., Teo,H.Y., Zhu,Y., Yong Lionel,C.C., Chiu,J.W., Lu,J. and Liu,H.
    Calpain 2 regulates IL-1alpha secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment
    Oncoimmunology14, 2451444-2451444. PubMed  Europe PubMed DOI
  2. Jeon,K.H., Park,S., Pak,E.S., Kim,J.A., Liu,Y., Hwang,S.Y., Na,Y. and Kwon,Y.
    Calpain 2 Isoform-Specific Cleavage of Filamin A Enhances HIF1alpha Nuclear Translocation, Promoting Metastasis in Triple-Negative Breast Cancer
    MedComm (2020)6, e70147-e70147. PubMed  Europe PubMed DOI  K
  3. Teng,X., Wang,Y., Huang,H., Ding,Y., Wang,J., Liu,M., Song,K., Shao,L., Yu,Y., Yang,Z. and Shen,Z.
    Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
    Adv Sci (Weinh)e2501112-e2501112. PubMed  Europe PubMed DOI
    4. 2024
  4. Baudry,M. and Bi,X.
    Revisiting the calpain hypothesis of learning and memory 40 years later
    Front Mol Neurosci17, 1337850-1337850. PubMed  Europe PubMed DOI  V
  5. Baudry,M., Wang,Y., Bi,X., Luo,Y.L., Wang,Z., Kamal,Z., Shirokov,A., Sullivan,E., Lagasca,D., Khalil,H., Lee,G., Fosnaugh,K., Bey,P., Mehdi,S. and Coulter,G.
    Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor
    Pharmacol Res Perspect12, e1181-e1181. PubMed  Europe PubMed DOI  I
  6. Ma,J., Kummarapurugu,A.B., Zheng,S., Ghio,A.J., Deshpande,L.S. and Voynow,J.A.
    Neutrophil Elastase Activates Macrophage Calpain as a Mechanism for Phagocytic Failure
    Am J Physiol Lung Cell Mol Physiol PubMed  Europe PubMed DOI
  7. Miyamoto,T., Kim,C., Chow,J., Dugas,J.C., DeGroot,J., Bagdasarian,A.L., Thottumkara,A.P., Larhammar,M., Calvert,M.E., Fox,B.M., Lewcock,J.W. and Kane,L.A.
    SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons
    J Biol Chem300, 105630-105630. PubMed  Europe PubMed DOI
  8. Zhang,Y., Wei,S., Chen,Z., Xu,R., Li,S.R., You,L., Wu,R., Zhang,Y., Liao,J.Y., Xu,X., Song,E. and Luo,M.L.
    LncRNA FAISL Inhibits Calpain 2-Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer
    Adv Sci (Weinh)e2407493-e2407493. PubMed  Europe PubMed DOI  K
    9. 2023
  9. Chang,Z., Niu,T., Shao,Q., Yue,J., Zhang,H., Tong,L., Gao,X. and Tang,B.
    Pt-Se-Bonded Nanoprobe for High-Fidelity Detection of Non-small Cell Lung Cancer and Enhancement of NIR II Photothermal Therapy
    Anal Chem95, 18426-18435. PubMed  Europe PubMed DOI
  10. Chen,Y., Wang,P., Li,Q., Yan,X. and Xu,T.
    The protease calpain2a limits innate immunity by targeting TRAF6 in teleost fish
    Commun Biol6, 355-355. PubMed  Europe PubMed DOI  K
  11. Ojima,K., Hata,S., Shinkai-Ouchi,F., Ono,Y. and Muroya,S.
    Calpain-3 not only proteolyzes calpain-1 and -2 but also is a substrate for calpain-1 and -2
    J Biochem174, 421-431. PubMed  Europe PubMed DOI
    12. 2022
  12. Rey,J., Breiden,M., Lux,V., Bluemke,A., Steindel,M., Ripkens,K., Mollers,B., Bravo Rodriguez,K., Boisguerin,P., Volkmer,R., Mieres-Perez,J., Clausen,T., Sanchez-Garcia,E. and Ehrmann,M.
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    Proc Natl Acad Sci U S A119, e2113520119-e2113520119. PubMed  Europe PubMed DOI
    13. 2021
  13. Muniappan,L., Okuyama,M., Javidan,A., Thiagarajan,D., Jiang,W., Moorleghen,J.J., Yang,L., Balakrishnan,A., Howatt,D.A., Uchida,H.A., Saido,T.C. and Subramanian,V.
    Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice
    Arterioscler Thromb Vasc Biol41, 1694-1709. PubMed  Europe PubMed DOI
  14. Tang,Y., Li,Y., Yu,G., Ling,Z., Zhong,K., Zilundu,P.L.M., Li,W., Fu,R. and Zhou,L.H.
    MicroRNA-137-3p Protects PC12 Cells Against Oxidative Stress by Downregulation of Calpain-2 and nNOS
    Cell Mol Neurobiol41, 1373-1387. PubMed  Europe PubMed DOI
  15. Wang,J., Ciampa,G., Zheng,D., Shi,Q., Chen,B., Abel,E.D., Peng,T., Hall,D.D. and Song,L.S.
    Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy
    Biochem J478, 3539-3553. PubMed  Europe PubMed DOI
    16. 2020
  16. Chen,Y., Chen,L., Hong,D., Chen,Z., Zhang,J., Fu,L., Pan,D., Zhang,Y., Xu,Y., Gan,S., Xiao,C., Tao,L. and Shen,X.
    Correction: Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2
    Cell Death Dis11, 532-532. PubMed  Europe PubMed DOI
  17. Cicognola,C., Satir,T.M., Brinkmalm,G., Matecko-Burmann,I., Agholme,L., Bergstrom,P., Becker,B., Zetterberg,H., Blennow,K. and Hoglund,K.
    Tauopathy-associated tau fragment ending at amino acid 224 is generated by calpain-2 cleavage
    J Alzheimers Dis74, 1143-1156. PubMed  Europe PubMed DOI  A
  18. Dewitt,S. and Hallett,M.B.
    Calpain activation by Ca(2+) and its role in phagocytosis
    Adv Exp Med Biol1246, 129-151. PubMed  Europe PubMed DOI
  19. Donkor,I.O., Xu,J., Liu,J. and Cameron,K.
    Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors
    Bioorg Med Chem115433-115433. PubMed  Europe PubMed DOI  I
  20. Goto,S., Ozaki,Y., Ozawa,F., Mizutani,E., Kitaori,T., Suzumori,N., Blomgren,K., Furuno,T. and Sugiura-Ogasawara,M.
    The investigation of calpain in human placenta with fetal growth restriction
    Am J Reprod Immunole13325-e13325. PubMed  Europe PubMed DOI
  21. Ko,Y.U., Song,H.Y., Kim,W.K., Yune,T.Y., Yun,N. and Oh,Y.J.
    Calpain-mediated cleavage of Fbxw7 during excitotoxicity
    Neurosci Lett736, 135265-135265. PubMed  Europe PubMed DOI  I
  22. Kwon,S.H., Wi,T., Park,Y.I., Kim,M.W., Lee,G., Higaki,T., Choi,J.H. and Lee,R.
    Noninvasive early detection of calpain 2-enriched non-small cell lung cancer using a human serum albumin-bounded calpain 2 nanosensor
    Bioconjug Chem31, 803-812. PubMed  Europe PubMed DOI  L
  23. Lahiri,S.K., Quick,A.P., Samson-Couterie,B., Hulsurkar,M., Elzenaar,I., van Oort,R.J. and Wehrens,X.H.T.
    Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling
    Basic Res Cardiol115, 49-49. PubMed  Europe PubMed DOI
  24. Li,Y., He,Z., Lv,H., Chen,W. and Chen,J.
    Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-alpha-induced autophagy in mouse hippocampal neurons
    J Cell Mol Med PubMed  Europe PubMed DOI
  25. Padmanabha,S. and Vallikannan,B.
    Fatty acids influence the efficacy of lutein in the modulation of alpha-crystallin chaperone function: Evidence from selenite induced cataract rat model
    Biochem Biophys Res Commun529, 425-431. PubMed  Europe PubMed DOI
  26. Panico,P., Hiriart,M., Ostrosky-Wegman,P. and Salazar,A.M.
    TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes
    J Mol Endocrinol65, 45-57. PubMed  Europe PubMed DOI
  27. Wang,Y., Liu,Y., Bi,X. and Baudry,M.
    Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death
    Cells9, PubMed  Europe PubMed DOI
  28. Yi,C., Wu,W., Zheng,D., Peng,G., Huang,H., Shen,Z. and Teng,X.
    Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis
    Cell Death Dis11, 533-533. PubMed  Europe PubMed DOI
  29. Zu,S.Q., Feng,Y.B., Zhu,C.J., Wu,X.S., Zhou,R.P., Li,G., Dai,B.B., Wang,Z.S., Xie,Y.Y., Li,Y., Ge,J.F. and Chen,F.H.
    Acid-sensing ion channel 1a mediates acid-induced pyroptosis through calpain-2/calcineurin pathway in rat articular chondrocytes
    Cell Biol Int44, 2140-2152. PubMed  Europe PubMed DOI
    30. 2019
  30. Antoniades,I., Charalambous,A., Christodoulou,N., Zanardelli,S. and Skourides,P.A.
    Methods of calpain inhibition to determine the role of calpains in embryo development in amphibians
    Methods Mol Biol1915, 249-259. PubMed  Europe PubMed DOI
  31. Baudry,M.
    Calpain-1 and calpain-2 in the brain: Dr. Jekill and Mr Hyde?
    Curr Neuropharmacol17, 823-829. PubMed  Europe PubMed DOI
  32. Biswas,A.K. and Tandon,S.
    Casein zymography for analysis of calpain-1 and calpain-2 activity
    Methods Mol Biol1915, 31-38. PubMed  Europe PubMed DOI
  33. Biswas,A.K. and Tandon,S.
    Single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography
    Methods Mol Biol1915, 3-11. PubMed  Europe PubMed DOI
  34. Del Carmen Lafita-Navarro,M. and Conacci-Sorrell,M.
    Identification of calpain-activated protein functions
    Methods Mol Biol1915, 149-160. PubMed  Europe PubMed DOI
  35. Duverle,D.A. and Mamitsuka,H.
    CalCleaveMKL: a tool for calpain cleavage prediction
    Methods Mol Biol1915, 121-147. PubMed  Europe PubMed DOI
  36. Gao,Y., Hall,C., MacLeod,J. and Greer,P.A.
    Genetic models of calpain deficiency and ectopic expression
    Methods Mol Biol1915, 261-274. PubMed  Europe PubMed DOI  K
  37. Kitagawa,S.
    Experimental manipulation of calpain activity in vitro
    Methods Mol Biol1915, 209-218. PubMed  Europe PubMed DOI  I
  38. Liu,Z.F., Ji,J.J., Zheng,D., Su,L. and Peng,T.
    Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation
    J Cell Physiol234, 10761-10770. PubMed  Europe PubMed DOI
  39. Liu,Z.X., Yu,K., Dong,J., Zhao,L., Liu,Z., Zhang,Q., Li,S., Du,Y. and Cheng,H.
    Precise prediction of calpain cleavage sites and their aberrance caused by mutations in cancer
    Front Genet10, 715-715. PubMed  Europe PubMed DOI  P
  40. McCartney,C.E. and Davies,P.L.
    Bacterial expression and purification of calpains
    Methods Mol Biol1915, 13-27. PubMed  Europe PubMed DOI  E
    41. 2018
  41. Ahmad,F., Das,D., Kommaddi,R.P., Diwakar,L., Gowaikar,R., Rupanagudi,K.V., Bennett,D.A. and Ravindranath,V.
    Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects
    Sci Rep8, 13119-13119. PubMed  Europe PubMed DOI
  42. Gao,X., Mao,Y.H., Xiao,C., Li,K., Liu,W., Li,L.Y. and Pang,J.
    Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-kappaB/DNMT1 signaling pathway
    Prostate78, 682-690. PubMed  Europe PubMed DOI
  43. Kling,A., Jantos,K., Mack,H., Hornberger,W., Backfisch,G., Lao,Y., Nijsen,M., Rendenbach-Mueller,B. and Moeller,A.
    Mitigating the metabolic liability of carbonyl reduction: novel calpain inhibitors with P1' extension
    ACS Med Chem Lett9, 221-226. PubMed  Europe PubMed DOI  I
  44. MacLeod,J.A., Gao,Y., Hall,C., Muller,W.J., Gujral,T.S. and Greer,P.A.
    Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib
    Oncotarget9, 33382-33395. PubMed  Europe PubMed DOI  K  I
  45. McCartney,C.E., Ye,Q., Campbell,R.L. and Davies,P.L.
    Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide
    J Biol Chem293, 17716-17730. PubMed  Europe PubMed DOI
  46. Nguyen,H.H., Volkov,A.N., Vandenbussche,G., Tompa,P. and Pauwels,K.
    In vivo biotinylated calpastatin improves the affinity purification of human m-calpain
    Protein Expr Purif145, 77-84. PubMed  Europe PubMed DOI
  47. Schwartz,A.D., Hall,C.L., Barney,L.E., Babbitt,C.C. and Peyton,S.R.
    Integrin alpha6 and EGFR signaling converge at mechanosensitive calpain 2
    Biomaterials178, 73-82. PubMed  Europe PubMed DOI
  48. Wang,Y., Bi,X. and Baudry,M.
    Calpain-2 as a therapeutic target for acute neuronal injury
    Expert Opin Ther Targets22, 19-29. PubMed  Europe PubMed DOI  V  T
  49. Wang,Y., Liu,Y., Lopez,D., Lee,M., Dayal,S., Hurtado,A., Bi,X. and Baudry,M.
    Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice
    J Neurotrauma35, 105-117. PubMed  Europe PubMed DOI  I
  50. Zhang,G., Fang,T., Chang,M., Li,J., Hong,Q., Bai,C. and Zhou,J.
    Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling
    Oncol Rep40, 1937-1946. PubMed  Europe PubMed DOI  K
    51. 2017
  51. McCartney,C.E., MacLeod,J.A., Greer,P.A. and Davies,P.L.
    An easy-to-use FRET protein substrate to detect calpain cleavage in vitro and in vivo
    Biochim Biophys Acta1865, 221-230. PubMed  Europe PubMed DOI  A
  52. Montgomery,D.S., Yu,L., Ghazi,Z.M., Thai,T.L., Al-Khalili,O., Ma,H.P., Eaton,D.C. and Alli,A.A.
    ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins
    Am J Physiol Cell Physiol313, C42-C53. PubMed  Europe PubMed DOI
  53. Nagayoshi,T., Isoda,K., Mamiya,N. and Kida,S.
    Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory
    Mol Brain10, 61-61. PubMed  Europe PubMed DOI  I
  54. Nguyen,H.H., Varadi,M., Tompa,P. and Pauwels,K.
    Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin
    PLoS ONE12, e0174125-e0174125. PubMed  Europe PubMed DOI
  55. Plantier,V. and Brocard,F.
    [Calpain as a new therapeutic target for treating spasticity after a spinal cord injury]
    Med Sci (Paris)33, 629-636. PubMed  Europe PubMed DOI  T
  56. Wang,Y., Hall,R.A., Lee,M., Kamgar-Parsi,A., Bi,X. and Baudry,M.
    The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation
    Sci Rep7, 11771-11771. PubMed  Europe PubMed DOI
    57. 2016
  57. Abeyrathna,P., Kovacs,L., Han,W. and Su,Y.
    Calpain-2 activates Akt via TGF-beta1-mTORC2 pathway in pulmonary artery smooth muscle cells
    Am J Physiol Cell Physiol311, C24-C34. PubMed  Europe PubMed DOI  I
  58. Baek,K.H., Yu,H.V., Kim,E., Na,Y. and Kwon,Y.
    Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway
    Oncotarget7, 30831-30844. PubMed  Europe PubMed DOI
  59. Baudry,M. and Bi,X.
    Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration
    Trends Neurosci39, 235-245. PubMed  Europe PubMed DOI
  60. Blanc,F., Furio,L., Moisy,D., Yen,H.L., Chignard,M., Letavernier,E., Naffakh,N., Mok,C.K. and Si-Tahar,M.
    Targeting host calpain proteases decreases influenza A virus infection
    Am J Physiol Lung Cell Mol Physiol310, L689-L699. PubMed  Europe PubMed DOI
  61. Hudson,I.L., Leemaqz,S.Y., Neffe,A.T. and Abell,A.D.
    Classifying calpain inhibitors for the treatment of cataracts: A self organising map (SOM) ANN/KM approach in drug discovery
    Stud Comput Intell628, 161-212. DOI  I
  62. Ji,J., Su,L. and Liu,Z.
    Critical role of calpain in inflammation
    Biomed Rep5, 647-652. PubMed  Europe PubMed DOI  V
  63. Liu,Y., Wang,Y., Zhu,G., Sun,J., Bi,X. and Baudry,M.
    A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation
    Neuropharmacology105, 471-477. PubMed  Europe PubMed DOI  I
  64. Low,K.E., Ler,S., Chen,K.J., Campbell,R.L., Hickey,J.L., Tan,J., Scully,C.C., Davies,P.L., Yudin,A.K. and Zaretsky,S.
    Rational design of calpain inhibitors based on calpastatin peptidomimetics
    J Med Chem59, 5403-5415. PubMed  Europe PubMed DOI  I
  65. Seinfeld,J., Baudry,N., Xu,X., Bi,X. and Baudry,M.
    Differential activation of calpain-1 and calpain-2 following kainate-induced seizure activity in rats and mice
    eNeuro3, PubMed  Europe PubMed DOI
  66. Shinkai-Ouchi,F., Koyama,S., Ono,Y., Hata,S., Ojima,K., Shindo,M., duVerle,D., Ueno,M., Kitamura,F., Doi,N., Takigawa,I., Mamitsuka,H. and Sorimachi,H.
    Predictions of cleavability of calpain proteolysis by quantitative structure-activity relationship analysis using newly determined cleavage sites and catalytic efficiencies of an oligopeptide array
    Mol Cell Proteomics15, 1262-1280. PubMed  Europe PubMed DOI  P
  67. Wang,Y., Lopez,D., Davey,P.G., Cameron,D.J., Nguyen,K., Tran,J., Marquez,E., Liu,Y., Bi,X. and Baudry,M.
    Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury
    Neurobiol Dis93, 121-128. PubMed  Europe PubMed DOI  I
  68. Yuasa,T., Amo-Shiinoki,K., Ishikura,S., Takahara,M., Matsuoka,T., Kaneto,H., Kuroda,A., Matsuhisa,M. and Hashida,S.
    Sequential cleavage of insulin receptor by calpain 2 and gamma-secretase impairs insulin signalling
    Diabetologia59, 2711-2721. PubMed  Europe PubMed DOI
    69. 2015
  69. Cagmat,E.B., Guingab-Cagmat,J.D., Vakulenko,V., Hayes,R.L. and Anagli,J.
    Potential use of calpain inhibitors as brain injury therapy
     PubMed  Europe PubMed  I
  70. Donkor,I.O.
    An updated patent review of calpain inhibitors (2012 - 2014)
    Expert Opin Ther Pat25, 17-31. PubMed  Europe PubMed DOI  I
  71. Lei,H.Y., Zhou,X.L., Ruan,Z.R., Sun,W.C., Eriani,G. and Wang,E.D.
    Calpain cleaves most components in the multiple aminoacyl-tRNA synthetase complex and affects their functions
    J Biol Chem290, 26314-26327. PubMed  Europe PubMed DOI
  72. Li,F.Z., Cai,P.C., Song,L.J., Zhou,L.L., Zhang,Q., Rao,S.S., Xia,Y., Xiang,F., Xin,J.B., Greer,P.A., Shi,H.Z., Su,Y., Ma,W.L. and Ye,H.
    Crosstalk between calpain activation and TGF-beta1 augments collagen-I synthesis in pulmonary fibrosis
    Biochim Biophys Acta1852, 1796-1804. PubMed  Europe PubMed DOI  K
  73. Menzies,F.M., Garcia-Arencibia,M., Imarisio,S., O'Sullivan,N.C., Ricketts,T., Kent,B.A., Rao,M.V., Lam,W., Green-Thompson,Z.W., Nixon,R.A., Saksida,L.M., Bussey,T.J., O'Kane,C.J. and Rubinsztein,D.C.
    Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity
    Cell Death Differ22, 433-444. PubMed  Europe PubMed DOI
  74. Rose,A.H., Huang,Z., Mafnas,C., Hara,J.H., Hoffmann,F.W., Hashimoto,A.S., Bertino,P. and Hoffmann,P.R.
    Calpain-2 inhibitor therapy reduces murine colitis and colitis-associated cancer
    Inflamm Bowel Dis21, 2005-2015. PubMed  Europe PubMed DOI  I
  75. Shintani-Ishida,K. and Yoshida,K.I.
    Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia-reperfusion
    Int J Cardiol197, 26-32. PubMed  Europe PubMed DOI
    76. 2014
  76. Borras,T.
    The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review
    J Ocul Pharmacol Ther30, 202-212. PubMed  Europe PubMed DOI
  77. Gokhin,D.S., Tierney,M.T., Sui,Z., Sacco,A. and Fowler,V.M.
    Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle
    Mol Biol Cell25, 852-865. PubMed  Europe PubMed DOI
  78. Jones,S.A., Duncan,J., Aitken,S.G., Coxon,J.M. and Abell,A.D.
    The preparation of macrocyclic calpain inhibitors by ring closing metathesis and cross metathesis
    Aust J Chem67, 1257-1263. DOI  I
  79. Kaneko,Y., Murphy,C.R. and Day,M.L.
    Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites
    Histochem Cell Biol141, 423-430. PubMed  Europe PubMed DOI  I
  80. Kanzaki,K., Kuratani,M., Matsunaga,S., Yanaka,N. and Wada,M.
    Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions
    J Muscle Res Cell Motil35, 179-189. PubMed  Europe PubMed DOI
  81. Kim,H., Kang,A.-Y., Ko,A.-R., Park,H.C., So,I., Park,J.H., Cheong,H.I., Hwang,Y.-H. and Ahn,C.
    Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations
    Exp Cell Res320, 62-68. PubMed  Europe PubMed DOI
  82. Low,K.E., Karunan Partha,S., Davies,P.L. and Campbell,R.L.
    Allosteric inhibitors of calpains: reevaluating inhibition by PD150606 and LSEAL
    Biochim Biophys Acta1840, 3367-3373. PubMed  Europe PubMed DOI  I
  83. Lu,S., Kanekura,K., Hara,T., Mahadevan,J., Spears,L.D., Oslowski,C.M., Martinez,R., Yamazaki-Inoue,M., Toyoda,M., Neilson,A., Blanner,P., Brown,C.M., Semenkovich,C.F., Marshall,B.A., Hershey,T., Umezawa,A., Greer,P.A. and Urano,F.
    A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome
    Proc Natl Acad Sci U S A111, E5292-E5301. PubMed  Europe PubMed DOI  T
  84. Nakajima,T., Shearer,T.R. and Azuma,M.
    Loss of calpastatin leads to activation of calpain in human lens epithelial cells
    Invest Ophthalmol Vis Sci55, 5278-5283. PubMed  Europe PubMed DOI  I
  85. Pawlinski,R.
    Inhibit the calpain to climb the mountain
    Blood123, 1123-1124. PubMed  Europe PubMed DOI
  86. Piatkov,K.I., Oh,J.H., Liu,Y. and Varshavsky,A.
    Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway
    Proc Natl Acad Sci U S A111, E817-E826. PubMed  Europe PubMed DOI
  87. Tyagi,T., Ahmad,S., Gupta,N., Sahu,A., Ahmad,Y., Nair,V., Chatterjee,T., Bajaj,N., Sengupta,S., Ganju,L., Singh,S.B. and Ashraf,M.Z.
    Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype
    Blood123, 1250-1260. PubMed  Europe PubMed DOI
  88. Yamashita,T. and Kwak,S.
    [Calpain plays a crucial role in TDP-43 pathology]
    Rinsho Shinkeigaku54, 1151-1154. PubMed  Europe PubMed DOI
    89. 2013
  89. Amini,M., Ma,C.L., Farazifard,R., Zhu,G., Zhang,Y., Vanderluit,J., Zoltewicz,J.S., Hage,F., Savitt,J.M., Lagace,D.C., Slack,R.S., Beique,J.C., Baudry,M., Greer,P.A., Bergeron,R. and Park,D.S.
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  97. Gao,W., Liu,J., Hu,M., Huang,M., Cai,S., Zeng,Z., Lin,B., Cao,X., Chen,J., Zeng,J.Z., Zhou,H. and Zhang,X.K.
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  98. Hubener,J., Weber,J.J., Richter,C., Honold,L., Weiss,A., Murad,F., Breuer,P., Wullner,U., Bellstedt,P., Paquet-Durand,F., Takano,J., Saido,T.C., Riess,O. and Nguyen,H.P.
    Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3)
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  100. Saraiva,N., Prole,D.L., Carrara,G., Johnson,B.F., Taylor,C.W., Parsons,M. and Smith,G.L.
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  102. Subramanian,V., Moorleghen,J.J., Balakrishnan,A., Howatt,D.A., Chishti,A.H. and Uchida,H.A.
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  103. Uribe,K.B., Etxebarria,A., Martin,C. and Ostolaza,H.
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