Literature for peptidase C02.002: calpain-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Binte Hanafi,Z., Mei,Y., Teo,H.Y., Zhu,Y., Yong Lionel,C.C., Chiu,J.W., Lu,J. and Liu,H. Calpain 2 regulates IL-1alpha secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment Oncoimmunology (2025) 14, 2451444-2451444. PubMed Europe PubMed DOI PMC EPMC
Jeon,K.H., Park,S., Pak,E.S., Kim,J.A., Liu,Y., Hwang,S.Y., Na,Y. and Kwon,Y. Calpain 2 Isoform-Specific Cleavage of Filamin A Enhances HIF1alpha Nuclear Translocation, Promoting Metastasis in Triple-Negative Breast Cancer MedComm (2020) (2025) 6, e70147-e70147. PubMed Europe PubMed DOI PMC EPMC K
Teng,X., Wang,Y., Huang,H., Ding,Y., Wang,J., Liu,M., Song,K., Shao,L., Yu,Y., Yang,Z. and Shen,Z. Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection Adv Sci (Weinh) (2025) , e2501112-e2501112. PubMed Europe PubMed DOI

2024

Baudry,M. and Bi,X. Revisiting the calpain hypothesis of learning and memory 40 years later Front Mol Neurosci (2024) 17, 1337850-1337850. PubMed Europe PubMed DOI PMC EPMC V
Baudry,M., Wang,Y., Bi,X., Luo,Y.L., Wang,Z., Kamal,Z., Shirokov,A., Sullivan,E., Lagasca,D., Khalil,H., Lee,G., Fosnaugh,K., Bey,P., Mehdi,S. and Coulter,G. Identification and neuroprotective properties of NA-184, a calpain-2 inhibitor Pharmacol Res Perspect (2024) 12, e1181-e1181. PubMed Europe PubMed DOI PMC EPMC I
Ma,J., Kummarapurugu,A.B., Zheng,S., Ghio,A.J., Deshpande,L.S. and Voynow,J.A. Neutrophil Elastase Activates Macrophage Calpain as a Mechanism for Phagocytic Failure Am J Physiol Lung Cell Mol Physiol (2024) PubMed Europe PubMed DOI
Miyamoto,T., Kim,C., Chow,J., Dugas,J.C., DeGroot,J., Bagdasarian,A.L., Thottumkara,A.P., Larhammar,M., Calvert,M.E., Fox,B.M., Lewcock,J.W. and Kane,L.A. SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons J Biol Chem (2024) 300, 105630-105630. PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Wei,S., Chen,Z., Xu,R., Li,S.R., You,L., Wu,R., Zhang,Y., Liao,J.Y., Xu,X., Song,E. and Luo,M.L. LncRNA FAISL Inhibits Calpain 2-Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer Adv Sci (Weinh) (2024) , e2407493-e2407493. PubMed Europe PubMed DOI K

2023

Chang,Z., Niu,T., Shao,Q., Yue,J., Zhang,H., Tong,L., Gao,X. and Tang,B. Pt-Se-Bonded Nanoprobe for High-Fidelity Detection of Non-small Cell Lung Cancer and Enhancement of NIR II Photothermal Therapy Anal Chem (2023) 95, 18426-18435. PubMed Europe PubMed DOI
Chen,Y., Wang,P., Li,Q., Yan,X. and Xu,T. The protease calpain2a limits innate immunity by targeting TRAF6 in teleost fish Commun Biol (2023) 6, 355-355. PubMed Europe PubMed DOI PMC EPMC K
Ojima,K., Hata,S., Shinkai-Ouchi,F., Ono,Y. and Muroya,S. Calpain-3 not only proteolyzes calpain-1 and -2 but also is a substrate for calpain-1 and -2 J Biochem (2023) 174, 421-431. PubMed Europe PubMed DOI

2022

Bar,J., Popp,Y., Koudelka,T., Tholey,A. and Mikhaylova,M. Regulation of microtubule detyrosination by Ca2+ and conventional calpains J Cell Sci (2022) 135 PubMed Europe PubMed DOI
Rey,J., Breiden,M., Lux,V., Bluemke,A., Steindel,M., Ripkens,K., Mollers,B., Bravo Rodriguez,K., Boisguerin,P., Volkmer,R., Mieres-Perez,J., Clausen,T., Sanchez-Garcia,E. and Ehrmann,M. An allosteric HTRA1-calpain 2 complex with restricted activation profile Proc Natl Acad Sci U S A (2022) 119, e2113520119-e2113520119. PubMed Europe PubMed DOI

2021

Muniappan,L., Okuyama,M., Javidan,A., Thiagarajan,D., Jiang,W., Moorleghen,J.J., Yang,L., Balakrishnan,A., Howatt,D.A., Uchida,H.A., Saido,T.C. and Subramanian,V. Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice Arterioscler Thromb Vasc Biol (2021) 41, 1694-1709. PubMed Europe PubMed DOI PMC EPMC
Tang,Y., Li,Y., Yu,G., Ling,Z., Zhong,K., Zilundu,P.L.M., Li,W., Fu,R. and Zhou,L.H. MicroRNA-137-3p Protects PC12 Cells Against Oxidative Stress by Downregulation of Calpain-2 and nNOS Cell Mol Neurobiol (2021) 41, 1373-1387. PubMed Europe PubMed DOI
Wang,J., Ciampa,G., Zheng,D., Shi,Q., Chen,B., Abel,E.D., Peng,T., Hall,D.D. and Song,L.S. Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy Biochem J (2021) 478, 3539-3553. PubMed Europe PubMed DOI

2020

Chen,Y., Chen,L., Hong,D., Chen,Z., Zhang,J., Fu,L., Pan,D., Zhang,Y., Xu,Y., Gan,S., Xiao,C., Tao,L. and Shen,X. Correction: Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2 Cell Death Dis (2020) 11, 532-532. PubMed Europe PubMed DOI PMC EPMC
Cicognola,C., Satir,T.M., Brinkmalm,G., Matecko-Burmann,I., Agholme,L., Bergstrom,P., Becker,B., Zetterberg,H., Blennow,K. and Hoglund,K. Tauopathy-associated tau fragment ending at amino acid 224 is generated by calpain-2 cleavage J Alzheimers Dis (2020) 74, 1143-1156. PubMed Europe PubMed DOI A
Dewitt,S. and Hallett,M.B. Calpain activation by Ca(2+) and its role in phagocytosis Adv Exp Med Biol (2020) 1246, 129-151. PubMed Europe PubMed DOI
Donkor,I.O., Xu,J., Liu,J. and Cameron,K. Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors Bioorg Med Chem (2020) , 115433-115433. PubMed Europe PubMed DOI I
Goto,S., Ozaki,Y., Ozawa,F., Mizutani,E., Kitaori,T., Suzumori,N., Blomgren,K., Furuno,T. and Sugiura-Ogasawara,M. The investigation of calpain in human placenta with fetal growth restriction Am J Reprod Immunol (2020) , e13325-e13325. PubMed Europe PubMed DOI
Ko,Y.U., Song,H.Y., Kim,W.K., Yune,T.Y., Yun,N. and Oh,Y.J. Calpain-mediated cleavage of Fbxw7 during excitotoxicity Neurosci Lett (2020) 736, 135265-135265. PubMed Europe PubMed DOI I
Kwon,S.H., Wi,T., Park,Y.I., Kim,M.W., Lee,G., Higaki,T., Choi,J.H. and Lee,R. Noninvasive early detection of calpain 2-enriched non-small cell lung cancer using a human serum albumin-bounded calpain 2 nanosensor Bioconjug Chem (2020) 31, 803-812. PubMed Europe PubMed DOI L
Lahiri,S.K., Quick,A.P., Samson-Couterie,B., Hulsurkar,M., Elzenaar,I., van Oort,R.J. and Wehrens,X.H.T. Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling Basic Res Cardiol (2020) 115, 49-49. PubMed Europe PubMed DOI
Li,Y., He,Z., Lv,H., Chen,W. and Chen,J. Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-alpha-induced autophagy in mouse hippocampal neurons J Cell Mol Med (2020) PubMed Europe PubMed DOI PMC EPMC
Padmanabha,S. and Vallikannan,B. Fatty acids influence the efficacy of lutein in the modulation of alpha-crystallin chaperone function: Evidence from selenite induced cataract rat model Biochem Biophys Res Commun (2020) 529, 425-431. PubMed Europe PubMed DOI
Panico,P., Hiriart,M., Ostrosky-Wegman,P. and Salazar,A.M. TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes J Mol Endocrinol (2020) 65, 45-57. PubMed Europe PubMed DOI
Wang,Y., Liu,Y., Bi,X. and Baudry,M. Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death Cells (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Yi,C., Wu,W., Zheng,D., Peng,G., Huang,H., Shen,Z. and Teng,X. Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis Cell Death Dis (2020) 11, 533-533. PubMed Europe PubMed DOI PMC EPMC
Zu,S.Q., Feng,Y.B., Zhu,C.J., Wu,X.S., Zhou,R.P., Li,G., Dai,B.B., Wang,Z.S., Xie,Y.Y., Li,Y., Ge,J.F. and Chen,F.H. Acid-sensing ion channel 1a mediates acid-induced pyroptosis through calpain-2/calcineurin pathway in rat articular chondrocytes Cell Biol Int (2020) 44, 2140-2152. PubMed Europe PubMed DOI

2019

Antoniades,I., Charalambous,A., Christodoulou,N., Zanardelli,S. and Skourides,P.A. Methods of calpain inhibition to determine the role of calpains in embryo development in amphibians Methods Mol Biol (2019) 1915, 249-259. PubMed Europe PubMed DOI
Baudry,M. Calpain-1 and calpain-2 in the brain: Dr. Jekill and Mr Hyde? Curr Neuropharmacol (2019) 17, 823-829. PubMed Europe PubMed DOI
Biswas,A.K. and Tandon,S. Casein zymography for analysis of calpain-1 and calpain-2 activity Methods Mol Biol (2019) 1915, 31-38. PubMed Europe PubMed DOI
Biswas,A.K. and Tandon,S. Single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography Methods Mol Biol (2019) 1915, 3-11. PubMed Europe PubMed DOI
Del Carmen Lafita-Navarro,M. and Conacci-Sorrell,M. Identification of calpain-activated protein functions Methods Mol Biol (2019) 1915, 149-160. PubMed Europe PubMed DOI
Duverle,D.A. and Mamitsuka,H. CalCleaveMKL: a tool for calpain cleavage prediction Methods Mol Biol (2019) 1915, 121-147. PubMed Europe PubMed DOI
Gao,Y., Hall,C., MacLeod,J. and Greer,P.A. Genetic models of calpain deficiency and ectopic expression Methods Mol Biol (2019) 1915, 261-274. PubMed Europe PubMed DOI K
Kitagawa,S. Experimental manipulation of calpain activity in vitro Methods Mol Biol (2019) 1915, 209-218. PubMed Europe PubMed DOI I
Liu,Z.F., Ji,J.J., Zheng,D., Su,L. and Peng,T. Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation J Cell Physiol (2019) 234, 10761-10770. PubMed Europe PubMed DOI
Liu,Z.X., Yu,K., Dong,J., Zhao,L., Liu,Z., Zhang,Q., Li,S., Du,Y. and Cheng,H. Precise prediction of calpain cleavage sites and their aberrance caused by mutations in cancer Front Genet (2019) 10, 715-715. PubMed Europe PubMed DOI PMC EPMC P
McCartney,C.E. and Davies,P.L. Bacterial expression and purification of calpains Methods Mol Biol (2019) 1915, 13-27. PubMed Europe PubMed DOI E

2018

Ahmad,F., Das,D., Kommaddi,R.P., Diwakar,L., Gowaikar,R., Rupanagudi,K.V., Bennett,D.A. and Ravindranath,V. Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects Sci Rep (2018) 8, 13119-13119. PubMed Europe PubMed DOI PMC EPMC
Gao,X., Mao,Y.H., Xiao,C., Li,K., Liu,W., Li,L.Y. and Pang,J. Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-kappaB/DNMT1 signaling pathway Prostate (2018) 78, 682-690. PubMed Europe PubMed DOI
Kling,A., Jantos,K., Mack,H., Hornberger,W., Backfisch,G., Lao,Y., Nijsen,M., Rendenbach-Mueller,B. and Moeller,A. Mitigating the metabolic liability of carbonyl reduction: novel calpain inhibitors with P1' extension ACS Med Chem Lett (2018) 9, 221-226. PubMed Europe PubMed DOI PMC EPMC I
MacLeod,J.A., Gao,Y., Hall,C., Muller,W.J., Gujral,T.S. and Greer,P.A. Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib Oncotarget (2018) 9, 33382-33395. PubMed Europe PubMed DOI PMC EPMC K I
McCartney,C.E., Ye,Q., Campbell,R.L. and Davies,P.L. Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide J Biol Chem (2018) 293, 17716-17730. PubMed Europe PubMed DOI
Nguyen,H.H., Volkov,A.N., Vandenbussche,G., Tompa,P. and Pauwels,K. In vivo biotinylated calpastatin improves the affinity purification of human m-calpain Protein Expr Purif (2018) 145, 77-84. PubMed Europe PubMed DOI
Schwartz,A.D., Hall,C.L., Barney,L.E., Babbitt,C.C. and Peyton,S.R. Integrin alpha6 and EGFR signaling converge at mechanosensitive calpain 2 Biomaterials (2018) 178, 73-82. PubMed Europe PubMed DOI
Wang,Y., Bi,X. and Baudry,M. Calpain-2 as a therapeutic target for acute neuronal injury Expert Opin Ther Targets (2018) 22, 19-29. PubMed Europe PubMed DOI V T
Wang,Y., Liu,Y., Lopez,D., Lee,M., Dayal,S., Hurtado,A., Bi,X. and Baudry,M. Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice J Neurotrauma (2018) 35, 105-117. PubMed Europe PubMed DOI I
Zhang,G., Fang,T., Chang,M., Li,J., Hong,Q., Bai,C. and Zhou,J. Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling Oncol Rep (2018) 40, 1937-1946. PubMed Europe PubMed DOI K

2017

McCartney,C.E., MacLeod,J.A., Greer,P.A. and Davies,P.L. An easy-to-use FRET protein substrate to detect calpain cleavage in vitro and in vivo Biochim Biophys Acta (2017) 1865, 221-230. PubMed Europe PubMed DOI A
Montgomery,D.S., Yu,L., Ghazi,Z.M., Thai,T.L., Al-Khalili,O., Ma,H.P., Eaton,D.C. and Alli,A.A. ENaC activity is regulated by calpain-2 proteolysis of MARCKS proteins Am J Physiol Cell Physiol (2017) 313, C42-C53. PubMed Europe PubMed DOI
Nagayoshi,T., Isoda,K., Mamiya,N. and Kida,S. Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory Mol Brain (2017) 10, 61-61. PubMed Europe PubMed DOI PMC EPMC I
Nguyen,H.H., Varadi,M., Tompa,P. and Pauwels,K. Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin PLoS ONE (2017) 12, e0174125-e0174125. PubMed Europe PubMed DOI
Plantier,V. and Brocard,F. [Calpain as a new therapeutic target for treating spasticity after a spinal cord injury] Med Sci (Paris) (2017) 33, 629-636. PubMed Europe PubMed DOI T
Wang,Y., Hall,R.A., Lee,M., Kamgar-Parsi,A., Bi,X. and Baudry,M. The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation Sci Rep (2017) 7, 11771-11771. PubMed Europe PubMed DOI PMC EPMC

2016

Abeyrathna,P., Kovacs,L., Han,W. and Su,Y. Calpain-2 activates Akt via TGF-beta1-mTORC2 pathway in pulmonary artery smooth muscle cells Am J Physiol Cell Physiol (2016) 311, C24-C34. PubMed Europe PubMed DOI I
Baek,K.H., Yu,H.V., Kim,E., Na,Y. and Kwon,Y. Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway Oncotarget (2016) 7, 30831-30844. PubMed Europe PubMed DOI
Baudry,M. and Bi,X. Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration Trends Neurosci (2016) 39, 235-245. PubMed Europe PubMed DOI
Blanc,F., Furio,L., Moisy,D., Yen,H.L., Chignard,M., Letavernier,E., Naffakh,N., Mok,C.K. and Si-Tahar,M. Targeting host calpain proteases decreases influenza A virus infection Am J Physiol Lung Cell Mol Physiol (2016) 310, L689-L699. PubMed Europe PubMed DOI
Hudson,I.L., Leemaqz,S.Y., Neffe,A.T. and Abell,A.D. Classifying calpain inhibitors for the treatment of cataracts: A self organising map (SOM) ANN/KM approach in drug discovery Stud Comput Intell (2016) 628, 161-212. DOI I
Ji,J., Su,L. and Liu,Z. Critical role of calpain in inflammation Biomed Rep (2016) 5, 647-652. PubMed Europe PubMed DOI PMC EPMC V
Liu,Y., Wang,Y., Zhu,G., Sun,J., Bi,X. and Baudry,M. A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation Neuropharmacology (2016) 105, 471-477. PubMed Europe PubMed DOI I
Low,K.E., Ler,S., Chen,K.J., Campbell,R.L., Hickey,J.L., Tan,J., Scully,C.C., Davies,P.L., Yudin,A.K. and Zaretsky,S. Rational design of calpain inhibitors based on calpastatin peptidomimetics J Med Chem (2016) 59, 5403-5415. PubMed Europe PubMed DOI I
Seinfeld,J., Baudry,N., Xu,X., Bi,X. and Baudry,M. Differential activation of calpain-1 and calpain-2 following kainate-induced seizure activity in rats and mice eNeuro (2016) 3 PubMed Europe PubMed DOI PMC EPMC
Shinkai-Ouchi,F., Koyama,S., Ono,Y., Hata,S., Ojima,K., Shindo,M., duVerle,D., Ueno,M., Kitamura,F., Doi,N., Takigawa,I., Mamitsuka,H. and Sorimachi,H. Predictions of cleavability of calpain proteolysis by quantitative structure-activity relationship analysis using newly determined cleavage sites and catalytic efficiencies of an oligopeptide array Mol Cell Proteomics (2016) 15, 1262-1280. PubMed Europe PubMed DOI P
Wang,Y., Lopez,D., Davey,P.G., Cameron,D.J., Nguyen,K., Tran,J., Marquez,E., Liu,Y., Bi,X. and Baudry,M. Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury Neurobiol Dis (2016) 93, 121-128. PubMed Europe PubMed DOI I
Yuasa,T., Amo-Shiinoki,K., Ishikura,S., Takahara,M., Matsuoka,T., Kaneto,H., Kuroda,A., Matsuhisa,M. and Hashida,S. Sequential cleavage of insulin receptor by calpain 2 and gamma-secretase impairs insulin signalling Diabetologia (2016) 59, 2711-2721. PubMed Europe PubMed DOI

2015

Cagmat,E.B., Guingab-Cagmat,J.D., Vakulenko,V., Hayes,R.L. and Anagli,J. Potential use of calpain inhibitors as brain injury therapy (2015) PubMed Europe PubMed I
Donkor,I.O. An updated patent review of calpain inhibitors (2012 - 2014) Expert Opin Ther Pat (2015) 25, 17-31. PubMed Europe PubMed DOI I
Lei,H.Y., Zhou,X.L., Ruan,Z.R., Sun,W.C., Eriani,G. and Wang,E.D. Calpain cleaves most components in the multiple aminoacyl-tRNA synthetase complex and affects their functions J Biol Chem (2015) 290, 26314-26327. PubMed Europe PubMed DOI
Li,F.Z., Cai,P.C., Song,L.J., Zhou,L.L., Zhang,Q., Rao,S.S., Xia,Y., Xiang,F., Xin,J.B., Greer,P.A., Shi,H.Z., Su,Y., Ma,W.L. and Ye,H. Crosstalk between calpain activation and TGF-beta1 augments collagen-I synthesis in pulmonary fibrosis Biochim Biophys Acta (2015) 1852, 1796-1804. PubMed Europe PubMed DOI K
Menzies,F.M., Garcia-Arencibia,M., Imarisio,S., O'Sullivan,N.C., Ricketts,T., Kent,B.A., Rao,M.V., Lam,W., Green-Thompson,Z.W., Nixon,R.A., Saksida,L.M., Bussey,T.J., O'Kane,C.J. and Rubinsztein,D.C. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity Cell Death Differ (2015) 22, 433-444. PubMed Europe PubMed DOI
Rose,A.H., Huang,Z., Mafnas,C., Hara,J.H., Hoffmann,F.W., Hashimoto,A.S., Bertino,P. and Hoffmann,P.R. Calpain-2 inhibitor therapy reduces murine colitis and colitis-associated cancer Inflamm Bowel Dis (2015) 21, 2005-2015. PubMed Europe PubMed DOI I
Shintani-Ishida,K. and Yoshida,K.I. Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia-reperfusion Int J Cardiol (2015) 197, 26-32. PubMed Europe PubMed DOI

2014

Borras,T. The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review J Ocul Pharmacol Ther (2014) 30, 202-212. PubMed Europe PubMed DOI
Gokhin,D.S., Tierney,M.T., Sui,Z., Sacco,A. and Fowler,V.M. Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle Mol Biol Cell (2014) 25, 852-865. PubMed Europe PubMed DOI
Jones,S.A., Duncan,J., Aitken,S.G., Coxon,J.M. and Abell,A.D. The preparation of macrocyclic calpain inhibitors by ring closing metathesis and cross metathesis Aust J Chem (2014) 67, 1257-1263. DOI I
Kaneko,Y., Murphy,C.R. and Day,M.L. Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites Histochem Cell Biol (2014) 141, 423-430. PubMed Europe PubMed DOI I
Kanzaki,K., Kuratani,M., Matsunaga,S., Yanaka,N. and Wada,M. Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions J Muscle Res Cell Motil (2014) 35, 179-189. PubMed Europe PubMed DOI
Kim,H., Kang,A.-Y., Ko,A.-R., Park,H.C., So,I., Park,J.H., Cheong,H.I., Hwang,Y.-H. and Ahn,C. Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations Exp Cell Res (2014) 320, 62-68. PubMed Europe PubMed DOI
Low,K.E., Karunan Partha,S., Davies,P.L. and Campbell,R.L. Allosteric inhibitors of calpains: reevaluating inhibition by PD150606 and LSEAL Biochim Biophys Acta (2014) 1840, 3367-3373. PubMed Europe PubMed DOI I
Lu,S., Kanekura,K., Hara,T., Mahadevan,J., Spears,L.D., Oslowski,C.M., Martinez,R., Yamazaki-Inoue,M., Toyoda,M., Neilson,A., Blanner,P., Brown,C.M., Semenkovich,C.F., Marshall,B.A., Hershey,T., Umezawa,A., Greer,P.A. and Urano,F. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome Proc Natl Acad Sci U S A (2014) 111, E5292-E5301. PubMed Europe PubMed DOI T
Nakajima,T., Shearer,T.R. and Azuma,M. Loss of calpastatin leads to activation of calpain in human lens epithelial cells Invest Ophthalmol Vis Sci (2014) 55, 5278-5283. PubMed Europe PubMed DOI I
Pawlinski,R. Inhibit the calpain to climb the mountain Blood (2014) 123, 1123-1124. PubMed Europe PubMed DOI PMC EPMC
Piatkov,K.I., Oh,J.H., Liu,Y. and Varshavsky,A. Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway Proc Natl Acad Sci U S A (2014) 111, E817-E826. PubMed Europe PubMed DOI
Tyagi,T., Ahmad,S., Gupta,N., Sahu,A., Ahmad,Y., Nair,V., Chatterjee,T., Bajaj,N., Sengupta,S., Ganju,L., Singh,S.B. and Ashraf,M.Z. Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype Blood (2014) 123, 1250-1260. PubMed Europe PubMed DOI
Yamashita,T. and Kwak,S. [Calpain plays a crucial role in TDP-43 pathology] Rinsho Shinkeigaku (2014) 54, 1151-1154. PubMed Europe PubMed DOI

2013

Amini,M., Ma,C.L., Farazifard,R., Zhu,G., Zhang,Y., Vanderluit,J., Zoltewicz,J.S., Hage,F., Savitt,J.M., Lagace,D.C., Slack,R.S., Beique,J.C., Baudry,M., Greer,P.A., Bergeron,R. and Park,D.S. Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury J Neurosci (2013) 33, 5773-5784. PubMed Europe PubMed DOI K
Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y. Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors Bioorg Chem (2013) 51, 24-30. PubMed Europe PubMed DOI I
Banoczi,Z., Tantos,A., Farkas,A., Majer,Z., Dokus,L.E., Tompa,P. and Hudecz,F. New m-calpain substrate-based azapeptide inhibitors J Pept Sci (2013) 19, 370-376. PubMed Europe PubMed DOI P I
Baudry,M., Chou,M.M. and Bi,X. Targeting calpain in synaptic plasticity Expert Opin Ther Targets (2013) 17, 579-592. PubMed Europe PubMed DOI V
Bhatti,G., Jayanthi,L., Vandevord,P. and Gebremichael,Y. Computational investigation of the key factors affecting the second stage activation mechanisms of domain II m-calpain J Mol Model (2013) 19, 779-792. PubMed Europe PubMed DOI
Briz,V., Hsu,Y.T., Li,Y., Lee,E., Bi,X. and Baudry,M. Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis J Neurosci (2013) 33, 4317-4328. PubMed Europe PubMed DOI
Clinkinbeard,T., Ghoshal,S., Craddock,S., Creed Pettigrew,L. and Guttmann,R.P. Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion Brain Res (2013) 1499, 129-135. PubMed Europe PubMed DOI
Elagib,K.E., Rubinstein,J.D., Delehanty,L.L., Ngoh,V.S., Greer,P.A., Li,S., Lee,J.K., Li,Z., Orkin,S.H., Mihaylov,I.S. and Goldfarb,A.N. Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation Dev Cell (2013) 27, 607-620. PubMed Europe PubMed DOI
Gao,W., Liu,J., Hu,M., Huang,M., Cai,S., Zeng,Z., Lin,B., Cao,X., Chen,J., Zeng,J.Z., Zhou,H. and Zhang,X.K. Regulation of proteolytic cleavage of retinoid X receptor-alpha by GSK-3beta Carcinogenesis (2013) 34, 1208-1215. PubMed Europe PubMed DOI
Hubener,J., Weber,J.J., Richter,C., Honold,L., Weiss,A., Murad,F., Breuer,P., Wullner,U., Bellstedt,P., Paquet-Durand,F., Takano,J., Saido,T.C., Riess,O. and Nguyen,H.P. Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3) Hum Mol Genet (2013) 22, 508-518. PubMed Europe PubMed DOI
Jones,S.A., Neilsen,P.M., Siew,L., Callen,D.F., Goldfarb,N.E., Dunn,B.M. and Abell,A.D. A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease ChemMedChem (2013) 8, 1918-1921. PubMed Europe PubMed DOI I
Saraiva,N., Prole,D.L., Carrara,G., Johnson,B.F., Taylor,C.W., Parsons,M. and Smith,G.L. hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2 J Cell Biol (2013) 202, 699-713. PubMed Europe PubMed DOI PMC EPMC
Shao,H., Travers,T., Camacho,C.J. and Wells,A. The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading Int J Biochem Cell Biol (2013) 45, 1051-1063. PubMed Europe PubMed DOI P
Subramanian,V., Moorleghen,J.J., Balakrishnan,A., Howatt,D.A., Chishti,A.H. and Uchida,H.A. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice PLoS ONE (2013) 8, e72214-e72214. PubMed Europe PubMed DOI PMC EPMC I
Uribe,K.B., Etxebarria,A., Martin,C. and Ostolaza,H. Calpain-mediated processing of adenylate cyclase toxin generates a cytosolic soluble catalytically active N-terminal domain PLoS ONE (2013) 8, e67648-e67648. PubMed Europe PubMed DOI PMC EPMC
Wang,C.Y., Xie,J.W., Wang,T., Xu,Y., Cai,J.H., Wang,X., Zhao,B.L., An,L. and Wang,Z.Y. Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease CNS Neurosci Ther (2013) 19, 820-833. PubMed Europe PubMed DOI
Wang,Y., Briz,V., Chishti,A., Bi,X. and Baudry,M. Distinct roles for mu-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration J Neurosci (2013) 33, 18880-18892. PubMed Europe PubMed DOI
Zanardelli,S., Christodoulou,N. and Skourides,P.A. Calpain2 protease: A new member of the Wnt/Ca(2+) pathway modulating convergent extension movements in Xenopus Dev Biol (2013) 384, 83-100. PubMed Europe PubMed DOI

2012

Campbell,R.L. and Davies,P.L. Structure-function relationships in calpains Biochem J (2012) 447, 335-351. PubMed Europe PubMed DOI V
Chen,H., Jiao,W., Jones,M.A., Coxon,J.M., Morton,J.D., Bickerstaffe,R., Pehere,A.D., Zvarec,O. and Abell,A.D. New tripeptide-based macrocyclic calpain inhibitors formed by N-alkylation of histidine Chem Biodivers (2012) 9, 2473-2484. PubMed Europe PubMed DOI I
Hata,S., Ueno,M., Kitamura,F. and Sorimachi,H. Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature J Biochem (2012) 151, 417-422. PubMed Europe PubMed DOI E
Kawashima,I., Liu,Z., Mullany,L.K., Mihara,T., Richards,J.S. and Shimada,M. EGF-Like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement Endocrinology (2012) 153, 3949-3959. PubMed Europe PubMed DOI
Lal,S., La Du,J., Tanguay,R.L. and Greenwood,J.A. Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment J Neurosci Res (2012) 90, 769-781. PubMed Europe PubMed DOI
Santos,D.M., Xavier,J.M., Morgado,A.L., Sola,S. and Rodrigues,C.M. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation PLoS ONE (2012) 7, e33468-e33468. PubMed Europe PubMed DOI PMC EPMC
Shen,C., Yu,Y., Li,H., Yan,G., Liu,M., Shen,H. and Yang,P. Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network Proteomics (2012) 12, 1917-1927. PubMed Europe PubMed DOI
Sorimachi,H., Hata,S. and Ono,Y. Calpain-2/m-calpain [ISSN:978-0-12-407743-0] (2012) 3, 2007-2011. DOI
Wang,C.F. and Huang,Y.S. Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons Mol Cell Biol (2012) 32, 3321-3332. PubMed Europe PubMed DOI

2011

Bozoky,Z., Rona,G., Klement,E., Medzihradszky,K.F., Merenyi,G., Vertessy,B.G. and Friedrich,P. Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide PLoS ONE (2011) 6, e19546-e19546. PubMed Europe PubMed DOI PMC EPMC P
Caberoy,N.B., Alvarado,G. and Li,W. Identification of calpain substrates by ORF phage display Molecules (2011) 16, 1739-1748. PubMed Europe PubMed DOI
Chou,J.S., Impens,F., Gevaert,K. and Davies,P.L. m-Calpain activation in vitro does not require autolysis or subunit dissociation Biochim Biophys Acta (2011) 1814, 864-872. PubMed Europe PubMed DOI
Donkor,I.O. Calpain inhibitors: a survey of compounds reported in the patent and scientific literature Expert Opin Ther Pat (2011) 21, 601-636. PubMed Europe PubMed DOI I
Huang,Z., Hoffmann,F.W., Norton,R.L., Hashimoto,A.C. and Hoffmann,P.R. Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages J Biol Chem (2011) 286, 34830-34838. PubMed Europe PubMed DOI
Khan,J., Davy,C.E., McIntosh,P.B., Jackson,D.J., Hinz,S., Wang,Q. and Doorbar,J. Role of calpain in the formation of human papillomavirus type 16 E1^E4 amyloid fibers and reorganization of the keratin network J Virol (2011) 85, 9984-9997. PubMed Europe PubMed DOI P
Liu,Z., Cao,J., Gao,X., Ma,Q., Ren,J. and Xue,Y. GPS-CCD: a novel computational program for the prediction of calpain cleavage sites PLoS ONE (2011) 6, e19001-e19001. PubMed Europe PubMed DOI PMC EPMC
Taneike,M., Mizote,I., Morita,T., Watanabe,T., Hikoso,S., Yamaguchi,O., Takeda,T., Oka,T., Tamai,T., Oyabu,J., Murakawa,T., Nakayama,H., Nishida,K., Takeda,J., Mochizuki,N., Komuro,I. and Otsu,K. Calpain protects the heart from hemodynamic stress J Biol Chem (2011) 286, 32170-32177. PubMed Europe PubMed DOI K

2010

Aroca-Aguilar,J.D., Martinez-Redondo,F., Sanchez-Sanchez,F., Coca-Prados,M. and Escribano,J. Functional role of proteolytic processing of recombinant myocilin in self-aggregation Invest Ophthalmol Vis Sci (2010) 51, 72-78. PubMed Europe PubMed DOI
Chakrabarti,S., Rizvi,M., Morin,K., Garg,R. and Freedman,J.E. The role of CD40L and VEGF in the modulation of angiogenesis and inflammation Vascul Pharmacol (2010) 53, 130-137. PubMed Europe PubMed DOI
Chan,K.T., Bennin,D.A. and Huttenlocher,A. Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK) J Biol Chem (2010) 285, 11418-11426. PubMed Europe PubMed DOI P
Farr,C. and Berger,S. Measuring calpain activity in fixed and living cells by flow cytometry J Vis Exp (2010) , 2050-2050. PubMed Europe PubMed DOI A
Huang,C.J., Gurlo,T., Haataja,L., Costes,S., Daval,M., Ryazantsev,S., Wu,X., Butler,A.E. and Butler,P.C. Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes J Biol Chem (2010) 285, 339-348. PubMed Europe PubMed DOI
Jang,H.S., Lal,S. and Greenwood,J.A. Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2 Neurochem Res (2010) 35, 1796-1804. PubMed Europe PubMed DOI K
Kar,P., Samanta,K., Shaikh,S., Chowdhury,A., Chakraborti,T. and Chakraborti,S. Mitochondrial calpain system: an overview Arch Biochem Biophys (2010) 495, 1-7. PubMed Europe PubMed DOI
Leloup,L., Shao,H., Bae,Y.H., Deasy,B., Stolz,D., Roy,P. and Wells,A. m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate J Biol Chem (2010) 285, 33549-33566. PubMed Europe PubMed DOI
Magnaghi-Jaulin,L., Marcilhac,A., Rossel,M., Jaulin,C., Benyamin,Y. and Raynaud,F. Calpain 2 is required for sister chromatid cohesion Chromosoma (2010) 119, 267-274. PubMed Europe PubMed DOI
Ovat,A., Li,Z.Z., Hampton,C.Y., Asress,S.A., Fernandez,F.M., Glass,J.D. and Powers,J.C. Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors J Med Chem (2010) 53, 6326-6336. PubMed Europe PubMed DOI I
Samanta,K., Kar,P., Chakraborti,T., Shaikh,S. and Chakraborti,S. Characteristic properties of endoplasmic reticulum membrane m-calpain, calpastatin and lumen m-calpain: a comparative study between membrane and lumen m-calpains J Biochem (2010) 147, 765-779. PubMed Europe PubMed DOI
Svensson,L., McDowall,A., Giles,K.M., Stanley,P., Feske,S. and Hogg,N. Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes PLoS ONE (2010) 5, e15090-e15090. PubMed Europe PubMed DOI PMC EPMC
Wells,A. and Leloup,L. Calpain Handb of Cell Signaling, 2/e (2010) 2, 999-1008. DOI V

2009

Abell,A.D., Jones,M.A., Coxon,J.M., Morton,J.D., Aitken,S.G., McNabb,S.B., Lee,H.Y., Mehrtens,J.M., Alexander,N.A., Stuart,B.G., Neffe,A.T. and Bickerstaffe,R. Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors Angew Chem Int Ed Engl (2009) 48, 1455-1458. PubMed Europe PubMed DOI I
Bevers,M.B., Lawrence,E., Maronski,M., Starr,N., Amesquita,M. and Neumar,R.W. Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity J Neurochem (2009) 108, 1237-1250. PubMed Europe PubMed DOI PMC EPMC
Camins,A., Crespo-Biel,N., Junyent,F., Verdaguer,E., Canudas,A.M. and Pallas,M. Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium Curr Drug Metab (2009) 10, 433-447. PubMed Europe PubMed DOI V
Doshi,S. and Lynch,D.R. Calpain and the glutamatergic synapse Front Biosci (Schol Ed) (2009) 1, 466-476. PubMed Europe PubMed V
Guyton,M.K., Brahmachari,S., Das,A., Samantaray,S., Inoue,J., Azuma,M., Ray,S.K. and Banik,N.L. Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells J Neurochem (2009) 110, 1895-1907. PubMed Europe PubMed DOI PMC EPMC I
Hayakawa,M., Hayakawa,H., Matsuyama,Y., Tamemoto,H., Okazaki,H. and Tominaga,S. Mature interleukin-33 is produced by calpain-mediated cleavage in vivo Biochem Biophys Res Commun (2009) 387, 218-222. PubMed Europe PubMed DOI
Janssens,V., Derua,R., Zwaenepoel,K., Waelkens,E. and Goris,J. Specific regulation of protein phosphatase 2A PR72/B'' subunits by calpain Biochem Biophys Res Commun (2009) 386, 676-681. PubMed Europe PubMed DOI
Jones,S.A., Jones,M.A., McNabb,S.B., Aitken,S.G., Coxon,J.M. and Abell,A.D. N-heterocyclic dipeptide aldehyde calpain inhibitors Protein Pept Lett (2009) 16, 1466-1472. PubMed Europe PubMed DOI I
Kelly,J.C., Cuerrier,D., Graham,L.A., Campbell,R.L. and Davies,P.L. Profiling of calpain activity with a series of FRET-based substrates Biochim Biophys Acta (2009) 1794, 1505-1509. PubMed Europe PubMed DOI A P
Mellgren,R.L., Miyake,K., Kramerova,I., Spencer,M.J., Bourg,N., Bartoli,M., Richard,I., Greer,P.A. and McNeil,P.L. Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases Biochim Biophys Acta (2009) 1793, 1886-1893. PubMed Europe PubMed DOI
Ozaki,T., Yamashita,T. and Ishiguro,S. Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria Biochim Biophys Acta (2009) 1793, 1848-1859. PubMed Europe PubMed DOI
Ravulapalli,R., Campbell,R.L., Gauthier,S.Y., Dhe-Paganon,S. and Davies,P.L. Distinguishing between calpain heterodimerization and homodimerization FEBS J (2009) 276, 973-982. PubMed Europe PubMed DOI
Wang,H.C., Huang,Y.S., Ho,C.C., Jeng,J.C. and Shih,H.M. SUMO modification modulates the activity of calpain-2 Biochem Biophys Res Commun (2009) 384, 444-449. PubMed Europe PubMed DOI

2008

Cortesio,C.L., Chan,K.T., Perrin,B.J., Burton,N.O., Zhang,S., Zhang,Z.Y. and Huttenlocher,A. Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion J Cell Biol (2008) 180, 957-971. PubMed Europe PubMed DOI PMC EPMC
Croall,D.E., Vanhooser,L.M. and Cashon,R.E. Detecting the active conformation of calpain with calpastatin-based reagents Biochim Biophys Acta (2008) 1784, 1676-1686. PubMed Europe PubMed DOI PMC EPMC
Hanna,R.A., Campbell,R.L. and Davies,P.L. Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin Nature (2008) 456, 409-412. PubMed Europe PubMed DOI S
Honda,M., Masui,F., Kanzawa,N., Tsuchiya,T. and Toyo-oka,T. Specific knockdown of m-calpain blocks myogenesis with cDNA deduced from the corresponding RNAi Am J Physiol Cell Physiol (2008) 294, C957-C965. PubMed Europe PubMed DOI
Jones,M.A., Morton,J.D., Coxon,J.M., McNabb,S.B., Lee,H.Y., Aitken,S.G., Mehrtens,J.M., Robertson,L.J., Neffe,A.T., Miyamoto,S., Bickerstaffe,R., Gately,K., Wood,J.M. and Abell,A.D. Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors Bioorg Med Chem (2008) 16, 6911-6923. PubMed Europe PubMed DOI I
Lee,H.Y., Morton,J.D., Robertson,L.J., McDermott,J.D., Bickerstaffe,R., Abell,A.D., Jones,M.A., Mehrtens,J.M. and Coxon,J.M. Evaluation of a novel calpain inhibitor as a treatment for cataract Clin Experiment Ophthalmol (2008) 36, 852-860. PubMed Europe PubMed DOI I
Lepage,S.E. and Bruce,A.E. Characterization and comparative expression of zebrafish calpain system genes during early development Dev Dyn (2008) 237, 819-829. PubMed Europe PubMed DOI
Liu,J., Liu,M.C. and Wang,K.K. Calpain in the CNS: from synaptic function to neurotoxicity Sci Signal (2008) 1, re1-re1. PubMed Europe PubMed DOI V
Moldoveanu,T., Gehring,K. and Green,D.R. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains Nature (2008) 456, 404-408. PubMed Europe PubMed DOI S
Nam,D.H., Lee,K.S., Kim,S.H., Kim,S.M., Jung,S.Y., Chung,S.H., Kim,H.J., Kim,N.D., Jin,C. and Lee,Y.S. Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors Bioorg Med Chem Lett (2008) 18, 205-209. PubMed Europe PubMed DOI I
Sprague,C.R., Fraley,T.S., Jang,H.S., Lal,S. and Greenwood,J.A. Phosphoinositide binding to the substrate regulates susceptibility to proteolysis by calpain J Biol Chem (2008) 283, 9217-9223. PubMed Europe PubMed DOI PMC EPMC P
Upla,P., Marjomaki,V., Nissinen,L., Nylund,C., Waris,M., Hyypia,T. and Heino,J. Calpain 1 and 2 are required for RNA replication of echovirus 1 J Virol (2008) 82, 1581-1590. PubMed Europe PubMed DOI PMC EPMC

2007

Abell,A.D., Jones,M.A., Neffe,A.T., Aitken,S.G., Cain,T.P., Payne,R.J., McNabb,S.B., Coxon,J.M., Stuart,B.G., Pearson,D., Lee,H.Y. and Morton,J.D. Investigation into the P3 binding domain of m-calpain using photoswitchable diazo- and triazene-dipeptide aldehydes: new anticataract agents J Med Chem (2007) 50, 2916-2920. PubMed Europe PubMed DOI I
[YEAR:17-1-2007]Banoczi,Z., Tantos,A., Farkas,A., Tompa,P., Friedrich,P. and Hudecz,F. Synthesis of cell-penetrating conjugates of calpain activator peptides Bioconjug Chem (17-1-2007) 18, 130-137. PubMed Europe PubMed DOI
Berg,U., Bang,P. and Carlsson-Skwirut,C. Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1 Biol Chem (2007) 388, 859-863. PubMed Europe PubMed DOI P
Bolshakov,V.Y. SCOPing out proteases in long-term memory Cell (2007) 128, 1029-1030. PubMed Europe PubMed DOI
Cuerrier,D., Moldoveanu,T., Campbell,R.L., Kelly,J., Yoruk,B., Verhelst,S.H., Greenbaum,D., Bogyo,M. and Davies,P.L. Development of calpain-specific inactivators by screening of positional scanning epoxide libraries J Biol Chem (2007) 282, 9600-9611. PubMed Europe PubMed DOI I
Goudenege,S., Dargelos,E., Claverol,S., Bonneu,M., Cottin,P. and Poussard,S. Comparative proteomic analysis of myotube caveolae after milli-calpain deregulation Proteomics (2007) 7, 3289-3298. PubMed Europe PubMed DOI
Mellgren,R.L., Zhang,W., Miyake,K. and McNeil,P.L. Calpain is required for the rapid, calcium-dependent repair of wounded plasma membrane J Biol Chem (2007) 282, 2567-2575. PubMed Europe PubMed DOI
Mellgren,R.L. and Huang,X. Fetuin A stabilizes m-calpain and facilitates plasma membrane repair J Biol Chem (2007) 282, 35868-35877. PubMed Europe PubMed DOI
Saito,M., Li,H., Thompson,V.F., Kunisaki,N. and Goll,D.E. Purification and characterization of calpain and calpastatin from rainbow trout, Oncorhynchus mykiss Comp Biochem Physiol B Biochem Mol Biol (2007) 146, 445-455. PubMed Europe PubMed DOI
Sanchez-Sanchez,F., Martinez-Redondo,F., Aroca-Aguilar,J.D., Coca-Prados,M. and Escribano,J. Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease J Biol Chem (2007) 282, 27810-27824. PubMed Europe PubMed DOI P
Shimizu,K., Phan,T., Mansuy,I.M. and Storm,D.R. Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory Cell (2007) 128, 1219-1229. PubMed Europe PubMed DOI PMC EPMC
Yu,C.G. and Geddes,J.W. Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury Neurochem Res (2007) 32, 2046-2053. PubMed Europe PubMed DOI I
Zakharov,V.V. and Mosevitsky,M.I. M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3 J Neurochem (2007) 101, 1539-1551. PubMed Europe PubMed DOI

2006

[YEAR:24-1-2006]Dutt,P., Croall,D.E., Arthur,J.S., Veyra,T.D., Williams,K., Elce,J.S. and Greer,P.A. m-Calpain is required for preimplantation embryonic development in mice BMC Dev Biol (24-1-2006) 6, 3-3. PubMed Europe PubMed DOI PMC EPMC K
Koohmaraie,M. and Geesink,G.H. Contribution of postmortem muscle biochemistry to the delivery of consistent meat quality with particular focus on the calpain system Meat Sci (2006) 74, 34-43. PubMed Europe PubMed DOI
Wu,H.Y. and Lynch,D.R. Calpain and synaptic function Mol Neurobiol (2006) 33, 215-236. PubMed Europe PubMed DOI V

2005

[YEAR:14-1-2005]Dennison,S.R., Dante,S., Hauss,T., Brandenburg,K., Harris,F. and Phoenix,D.A. Investigations into the membrane interactions of m-calpain domain V Biophys J (14-1-2005) 88, 3008-3017. PubMed Europe PubMed DOI PMC EPMC
[YEAR:26-5-2005]Goudenege,S., Poussard,S., Dulong,S. and Cottin,P. Biologically active milli-calpain associated with caveolae is involved in a spatially compartmentalised signalling involving protein kinase C alpha and myristoylated alanine-rich C-kinase substrate (MARCKS) Int J Biochem Cell Biol (26-5-2005) 37, 1900-1910. PubMed Europe PubMed DOI I
Ma,H., Azuma,M. and Shearer,T.R. Degradation of human aquaporin 0 by m-calpain FEBS Lett (2005) 579, 6745-6748. PubMed Europe PubMed DOI
Salem,M., Nath,J., Rexroad,C.E., Killefer,J. and Yao,J. Identification and molecular characterization of the rainbow trout calpains (Capn1 and Capn2): their expression in muscle wasting during starvation Comp Biochem Physiol B Biochem Mol Biol (2005) 140, 63-71. PubMed Europe PubMed DOI
Wells,A., Huttenlocher,A. and Lauffenburger,D.A. Calpain proteases in cell adhesion and motility Int Rev Cytol (2005) 245, 1-16. PubMed Europe PubMed DOI V
Zakharov,V.V., Bogdanova,M.N. and Mosevitsky,M.I. Specific proteolysis of neuronal protein GAP-43 by calpain: characterization, regulation, and physiological role Biochemistry (Mosc) (2005) 70, 897-907. PubMed Europe PubMed I

2004

[YEAR:19-2-2004]Alexa,A., Bozoky,Z., Farkas,A., Tompa,P. and Friedrich,P. Contribution of distinct structural elements to activation of calpain by Ca2+ ions J Biol Chem (19-2-2004) 279, 20118-20126. PubMed Europe PubMed DOI
[YEAR:10-9-2004]Franco,S., Perrin,B. and Huttenlocher,A. Isoform specific function of calpain 2 in regulating membrane protrusion Exp Cell Res (10-9-2004) 299, 179-187. PubMed Europe PubMed DOI
[YEAR:29-10-2004]Friedrich,P. The intriguing Ca2+ requirement of calpain activation Biochem Biophys Res Commun (29-10-2004) 323, 1131-1133. PubMed Europe PubMed DOI
[YEAR:19-12-2004]Honda,S., Marumoto,T., Hirota,T., Nitta,M., Arima,Y., Ogawa,M. and Saya,H. Activation of m-calpain is required for chromosome alignment on the metaphase plate during mitosis J Biol Chem (19-12-2004) 279, 10615-10623. PubMed Europe PubMed DOI
[YEAR:29-10-2004]Hosfield,C.M., Elce,J.S. and Jia,Z. Activation of calpain by Ca2+: roles of the large subunit N-terminal and domain III-IV linker peptides J Mol Biol (29-10-2004) 343, 1049-1053. PubMed Europe PubMed DOI
Lakshmikuttyamma,A., Selvakumar,P., Sharma,A.R., Anderson,D.H. and Sharma,R.K. In vitro proteolytic degradation of bovine brain calcineurin by m-calpain Neurochem Res (2004) 29, 1913-1921. PubMed Europe PubMed DOI
[YEAR:3-5-2004]Li,H., Thompson,V.F. and Goll,D.E. Effects of autolysis on properties of mu- and m-calpain Biochim Biophys Acta (3-5-2004) 1691, 91-103. PubMed Europe PubMed DOI
Moldoveanu,T., Jia,Z. and Davies,P.L. Calpain activation by cooperative Ca2+ binding at two non-EF-hand sites J Biol Chem (2004) 279, 6106-6114. PubMed Europe PubMed DOI
[YEAR:9-3-2004]Otani,K., Han,D.H., Ford,E.L., Garcia-Roves,P.M., Ye,H., Horikawa,Y., Bell,G.I., Holloszy,J.O. and Polonsky,K.S. Calpain system regulates muscle mass and glucose transporter GLUT4 turnover J Biol Chem (9-3-2004) 279, 20915-20920. PubMed Europe PubMed DOI
Sato,K., Hattori,S., Irie,S., Sorimachi,H., Inomata,M. and Kawashima,S. Degradation of fodrin by m-calpain in fibroblasts adhering to fibrillar collagen I gel J Biochem (2004) 136, 777-785. PubMed Europe PubMed DOI
[YEAR:10-12-2004]Shaw,G., Yang,C., Zhang,L., Cook,P., Pike,B. and Hill,W.D. Characterization of the bovine neurofilament NF-M protein and cDNA sequence, and identification of in vitro and in vivo calpain cleavage sites Biochem Biophys Res Commun (10-12-2004) 325, 619-625. PubMed Europe PubMed DOI
Sorimachi,H. m-Calpain [ISSN:0-12-079610-4] (2004) 2, 1211-1213. V
[YEAR:23-8-2004]Zalewska,T., Thompson,V.F. and Goll,D.E. Effect of phosphatidylinositol and inside-out erythrocyte vesicles on autolysis of mu- and m-calpain from bovine skeletal muscle Biochim Biophys Acta (23-8-2004) 1693, 125-133. PubMed Europe PubMed DOI

2003

[YEAR:1-8-2003]Azuma,M., Tamada,Y., Kanaami,S., Nakajima,E., Nakamura,Y., Fukiage,C., Forsberg,N.E., Duncan,M.K. and Shearer,T.R. Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins Biochem Biophys Res Commun (1-8-2003) 307, 558-563. PubMed Europe PubMed DOI K
[YEAR:19-8-2003]Carragher,N.O., Westhoff,M.A., Fincham,V.J., Schaller,M.D. and Frame,M.C. A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src Curr Biol (19-8-2003) 13, 1442-1450. PubMed Europe PubMed DOI
[YEAR:14-2-2003]Dedieu,S., Mazeres,G., Dourdin,N., Cottin,P. and Brustis,J.J. Transactivation of capn2 by myogenic regulatory factors during myogenesis J Mol Biol (14-2-2003) 326, 453-465. PubMed Europe PubMed DOI
Goll,D.E., Thompson,V.F., Li,H., Wei,W. and Cong,J. The calpain system Physiol Rev (2003) 83, 731-801. PubMed Europe PubMed DOI
[YEAR:27-2-2003]Inoue,J., Nakamura,M., Cui,Y.S., Sakai,Y., Sakai,O., Hill,J.R., Wang,K.K. and Yuen,P.W. Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor J Med Chem (27-2-2003) 46, 868-871. PubMed Europe PubMed DOI I
[YEAR:1-8-2003]Mamoune,A., Luo,J.H., Lauffenburger,D.A. and Wells,A. Calpain-2 as a target for limiting prostate cancer invasion Cancer Res (1-8-2003) 63, 4632-4640. PubMed Europe PubMed
Moldoveanu,T., Hosfield,C.M., Lim,D., Jia,Z. and Davies,P.L. Calpain silencing by a reversible intrinsic mechanism Nat Struct Biol (2003) 10, 371-378. PubMed Europe PubMed DOI S
[YEAR:1-12-2003]Nakamura,M., Miyashita,H., Yamaguchi,M., Shirasaki,Y., Nakamura,Y. and Inoue,J. Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors Bioorg Med Chem (1-12-2003) 11, 5449-5460. PubMed Europe PubMed DOI I
Ray,S.K., Hogan,E.L. and Banik,N.L. Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors Brain Res Brain Res Rev (2003) 42, 169-185. PubMed Europe PubMed DOI I
[YEAR:8-5-2003]Smith,S.D., Jia,Z., Huynh,K.K., Wells,A. and Elce,J.S. Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation FEBS Lett (8-5-2003) 542, 115-118. PubMed Europe PubMed DOI
[YEAR:30-5-2003]Thompson,V.F., Lawson,K.R., Barlow,J. and Goll,D.E. Digestion of mu- and m-calpain by trypsin and chymotrypsin Biochim Biophys Acta (30-5-2003) 1648, 140-153. PubMed Europe PubMed DOI
[YEAR:18-4-2003]Todd,B., Moore,D., Deivanayagam,C.C., Lin,G.D., Chattopadhyay,D., Maki,M., Wang,K.K. and Narayana,S.V. A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor J Mol Biol (18-4-2003) 328, 131-146. PubMed Europe PubMed DOI S I

2002

Adamec,E., Mohan,P., Vonsattel,J.P. and Nixon,R.A. Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2 Acta Neuropathol (Berl) (2002) 104, 92-104. PubMed Europe PubMed DOI
Carragher,N.O. and Frame,M.C. Calpain: a role in cell transformation and migration Int J Biochem Cell Biol (2002) 34, 1539-1543. PubMed Europe PubMed DOI
[YEAR:1-10-2002]Dutt,P., Spriggs,C.N., Davies,P.L., Jia,Z. and Elce,J.S. Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain Biochem J (1-10-2002) 367, 263-269. PubMed Europe PubMed DOI PMC EPMC
Inomata,M., Hayashi,M., Ito,Y., Matsubara,Y., Takehana,M., Kawashima,S. and Shumiya,S. Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR) Curr Eye Res (2002) 25, 207-213. PubMed Europe PubMed DOI

2001

Cao,Y., Zhao,H. and Grunz,H. XCL-2 is a novel m-type calpain and disrupts morphogenetic movements during embryogenesis in Xenopus laevis Dev Growth Differ (2001) 43, 563-571. PubMed Europe PubMed DOI
Cottin,P., Thompson,V.F., Sathe,S.K., Szpacenko,A. and Goll,D.E. Autolysis of mu- and m-calpain from bovine skeletal muscle Biol Chem (2001) 382, 767-776. PubMed Europe PubMed DOI
[YEAR:21-12-2001]Dourdin,N., Bhatt,A.K., Dutt,P., Greer,P.A., Arthur,J.S., Elce,J.S. and Huttenlocher,A. Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts J Biol Chem (21-12-2001) 276, 48382-48388. PubMed Europe PubMed DOI K
[YEAR:20-7-2001]Hata,S., Sorimachi,H., Nakagawa,K., Maeda,T., Abe,K. and Suzuki,K. Domain II of m-calpain is a Ca(2+)-dependent cysteine protease FEBS Lett (20-7-2001) 501, 111-114. PubMed Europe PubMed
[YEAR:9-3-2001]Hosfield,C.M., Moldoveanu,T., Davies,P.L., Elce,J.S. and Jia,Z. Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain J Biol Chem (9-3-2001) 276, 7404-7407. PubMed Europe PubMed DOI
Nakagawa,K., Masumoto,H., Sorimachi,H. and Suzuki,K. Dissociation of m-calpain subunits occurs after autolysis of the N-terminus of the catalytic subunit, and is not required for activation J Biochem (2001) 130, 605-611. PubMed Europe PubMed
Purintrapiban,J., Wang,M. and Forsberg,N.E. Identification of glycogen phosphorylase and creatine kinase as calpain substrates in skeletal muscle Int J Biochem Cell Biol (2001) 33, 531-540. PubMed Europe PubMed DOI
Reverter,D., Strobl,S., Fernandez-Catalan,C., Sorimachi,H., Suzuki,K. and Bode,W. Structural basis for possible calcium-induced activation mechanisms of calpains Biol Chem (2001) 382, 753-766. PubMed Europe PubMed DOI
Reverter,D., Sorimachi,H. and Bode,W. The structure of calcium-free human m-calpain: implications for calcium activation and function Trends Cardiovasc Med (2001) 11, 222-229. PubMed Europe PubMed DOI S
Sato,K. and Kawashima,S. Calpain function in the modulation of signal transduction molecules Biol Chem (2001) 382, 743-751. PubMed Europe PubMed DOI
Shih,M., David,L.L., Lampi,K.J., Ma,H., Fukiage,C., Azuma,M. and Shearer,T.R. Proteolysis by m-calpain enhances in vitro light scattering by crystallins from human and bovine lenses Curr Eye Res (2001) 22, 458-469. PubMed Europe PubMed DOI

2000

Arthur,J.S., Elce,J.S., Hegadorn,C., Williams,K. and Greer,P.A. Disruption of the murine calpain small subunit gene, Capn4: Calpain is essential for embryonic development but not for cell growth and division Mol Cell Biol (2000) 20, 4474-4481. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:18-1-2000]Strobl,S., Fernandez-Catalan,C., Braun,M., Huber,R., Masumoto,H., Nakagawa,K., Irie,A., Sorimachi,H., Bourenkow,G., Bartunik,H., Suzuki,K. and Bode,W. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium Proc Natl Acad Sci U S A (18-1-2000) 97, 588-592. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:19-1-2000]Thompson,V.F., Lawson,K. and Goll,D.E. Effect of mu-calpain on m-calpain Biochem Biophys Res Commun (19-1-2000) 267, 495-499. PubMed Europe PubMed DOI
[YEAR:15-3-2000]Thompson,V.F., Saldana,S., Cong,J. and Goll,D.E. A BODIPY fluorescent microplate assay for measuring activity of calpains and other proteases Anal Biochem (15-3-2000) 279, 170-178. PubMed Europe PubMed DOI A

1999

[YEAR:15-12-1999]Hosfield,C.M., Elce,J.S., Davies,P.L. and Jia,Z. Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation EMBO J (15-12-1999) 18, 6880-6889. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:22-10-1999]Pfaff,M., Du,X. and Ginsberg,M.H. Calpain cleavage of integrin beta cytoplasmic domains FEBS Lett (22-10-1999) 460, 17-22. PubMed Europe PubMed DOI
[YEAR:2-4-1999]Suo,S., Koike,H., Sorimachi,H., Ishiura,S. and Suzuki,K. Association and dissociation of the calcium-binding domains of calpain by Ca2+ Biochem Biophys Res Commun (2-4-1999) 257, 63-66. PubMed Europe PubMed DOI

1998

Balcerzak,D., Cottin,P., Poussard,S., Cucuron,A., Brustis,J.J. and Ducastaing,A. Calpastatin-modulation of m-calpain activity is required for myoblast fusion Eur J Cell Biol (1998) 75, 247-253. PubMed Europe PubMed DOI
[YEAR:13-10-1998]Huang,J. and Forsberg,N.E. Role of calpain in skeletal-muscle protein degradation Proc Natl Acad Sci U S A (13-10-1998) 95, 12100-12105. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-1-1998]James,T., Matzelle,D., Bartus,R., Hogan,E.L. and Banik,N.L. New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro J Neurosci Res (15-1-1998) 51, 218-222. PubMed Europe PubMed DOI I
Kawashima,S., Akanuma,H. and Asaoka,K. Comparison of calpains from rabbit, monkey, human and rat Biol Chem (1998) 379, 201-204. PubMed Europe PubMed
Masumoto,H., Yoshizawa,T., Sorimachi,H., Nishino,T., Ishiura,S. and Suzuki,K. Overexpression, purification, and characterization of human m-calpain and its active site mutant, m-C105S-calpain, using a baculovirus expression system J Biochem (1998) 124, 957-961. PubMed Europe PubMed E
[YEAR:27-2-1998]Shih,M., Lampi,K.J., Shearer,T.R. and David,L.L. Cleavage of beta crystallins during maturation of bovine lens Mol Vis (27-2-1998) 4, 4-4. PubMed Europe PubMed
Wells,G.J. and Bihovsky,R. Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments Expert Opin Ther Pat (1998) 8, 1707-1727. V I

1997

Blanchard,H., Grochulski,P., Li,Y., Arthur,J.S., Davies,P.L., Elce,J.S. and Cygler,M. Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes Nat Struct Biol (1997) 4, 532-538. PubMed Europe PubMed DOI S
Elce,J.S., Hegadorn,C. and Arthur,J.S. Autolysis, Ca2+ requirement, and heterodimer stability in m-calpain J Biol Chem (1997) 272, 11268-11275. PubMed Europe PubMed DOI
Fukiage,C., Azuma,M., Nakamura,Y., Tamada,Y., Nakamura,M. and Shearer,T.R. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses Biochim Biophys Acta (1997) 1361, 304-312. PubMed Europe PubMed DOI I
Lin,G.D., Chattopadhyay,D., Maki,M., Takano,E., Hatanaka,M., DeLucas,L. and Narayana,S.V. Purification, crystallization and preliminary X-ray diffraction studies of recombinant calcium-binding domain of the small subunit of porcine calpain Acta Crystallogr D Biol Crystallogr (1997) 53, 474-476. PubMed Europe PubMed DOI
Lin,G.D., Chattopadhyay,D., Maki,M., Wang,K.K., Carson,M., Jin,L., Yuen,P.W., Takano,E., Hatanaka,M., DeLucas,L.J. and Narayana,S.V. Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding Nat Struct Biol (1997) 4, 539-547. PubMed Europe PubMed DOI S I

1996

Arthur,J.S. and Crawford,C. Investigation of the interaction of m-calpain with phospholipids: calpain-phospholipid interactions Biochim Biophys Acta (1996) 1293, 201-206. PubMed Europe PubMed DOI
Arthur,J.S. and Elce,J.S. Interaction of aspartic acid-104 and proline-287 with the active site of m-calpain Biochem J (1996) 319, 535-541. PubMed Europe PubMed PMC EPMC
Li,Z., Ortega-Vilain,A.C., Patil,G.S., Chu,D.L., Foreman,J.E., Eveleth,D.D. and Powers,J.C. Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases J Med Chem (1996) 39, 4089-4098. PubMed Europe PubMed DOI I
[YEAR:25-6-1996]Wang,K.K., Nath,R., Posner,A., Raser,K.J., Buroker-Kilgore,M., Hajimohammadreza,I., Probert,A., Marcoux,F.W., Ye,Q., Takano,E., Hatanaka,M., Maki,M., Caner,H., Collins,J.L., Fergus,A., Lee,K.S., Lunney,E.A., Hays,S.J. and Yuen,P. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective Proc Natl Acad Sci U S A (25-6-1996) 93, 6687-6692. PubMed Europe PubMed DOI PMC EPMC I
Wang,K.K., Nath,R., Raser,K.J. and Hajimohammadreza,I. Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures Arch Biochem Biophys (1996) 331, 208-214. PubMed Europe PubMed DOI I

1995

Arthur,J.S., Gauthier,S. and Elce,J.S. Active site residues in m-calpain: identification by site-directed mutagenesis FEBS Lett (1995) 368, 397-400. PubMed Europe PubMed DOI
Du,X., Saido,T.C., Tsubuki,S., Indig,F.E., Williams,M.J. and Ginsberg,M.H. Calpain cleavage of the cytoplasmic domain of the integrin beta3 subunit J Biol Chem (1995) 270, 26146-26151. PubMed Europe PubMed DOI
Elce,J.S., Hegadorn,C., Gauthier,S., Vince,J.W. and Davies,P.L. Recombinant calpain II: improved expression systems and production of a C105A active-site mutant for crystallography Protein Eng (1995) 8, 843-848. PubMed Europe PubMed E
Tompa,P., Schad,E., Baki,A., Alexa,A., Batke,J. and Friedrich,P. An ultrasensitive, continuous fluorometric assay for calpain activity Anal Biochem (1995) 228, 287-293. PubMed Europe PubMed DOI A

1994

Croall,D.E. and McGrody,K.S. Domain structure of calpain: mapping the binding site for calpastatin Biochemistry (1994) 33, 13223-13230. PubMed Europe PubMed
Figueiredo-Pereira,M.E., Banik,N. and Wilk,S. Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain J Neurochem (1994) 62, 1989-1994. PubMed Europe PubMed I
Graham-Siegenthaler,K., Gauthier,S., Davies,P.L. and Elce,J.S. Active recombinant rat calpain II. Bacterially produced large and small subunits associate both in vivo and in vitro J Biol Chem (1994) 269, 30457-30460. PubMed Europe PubMed
[YEAR:13-6-1994]Saido,T.C., Nagao,S., Shiramine,M., Tsukaguchi,M., Yoshizawa,T., Sorimachi,H., Ito,H., Tsuchiya,T., Kawashima,S. and Suzuki,K. Distinct kinetics of subunit autolysis in mammalian m-calpain activation FEBS Lett (13-6-1994) 346, 263-267. PubMed Europe PubMed DOI

1993

[YEAR:19-10-1993]DeLuca,C.I., Davies,P.L., Samis,J.A. and Elce,J.S. Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunit Biochim Biophys Acta (19-10-1993) 1216, 81-93. PubMed Europe PubMed DOI S
Sun,W., Ji,S.Q., Ebert,P.J., Bidwell,C.A. and Hancock,D.L. Cloning the partial cDNAs of mu-calpain and m-calpain from porcine skeletal muscle Biochimie (1993) 75, 931-936. PubMed Europe PubMed DOI
Ye,S.Q., Reardon,C.A. and Getz,G.S. Inhibition of apolipoprotein E degradation in a post-Golgi compartment by a cysteine protease inhibitor J Biol Chem (1993) 268, 8497-8502. PubMed Europe PubMed I

1992

Goll,D.E., Thompson,V.F., Taylor,R.G. and Zalewska,T. Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin? Bioessays (1992) 14, 549-556. PubMed Europe PubMed DOI

1991

Mellgren,R.L. Proteolysis of nuclear proteins by mu-calpain and m-calpain J Biol Chem (1991) 266, 13920-13924. PubMed Europe PubMed
Nishimura,T. and Goll,D.E. Binding of calpain fragments to calpastatin J Biol Chem (1991) 266, 11842-11850. PubMed Europe PubMed
Pontremoli,S., Melloni,E., Viotti,P.L., Michetti,M., Salamino,F. and Horecker,B.L. Identification of two calpastatin forms in rat skeletal muscle and their susceptibility to digestion by homologous calpains Arch Biochem Biophys (1991) 288, 646-652. PubMed Europe PubMed DOI

1990

Bradford,H.N., Schmaier,A.H. and Colman,R.W. Kinetics of inhibition of platelet calpain II by human kininogens Biochem J (1990) 270, 83-90. PubMed Europe PubMed PMC EPMC

1989

McCelland,P., Lash,J.A. and Hathaway,D.R. Identification of major autolytic cleavage sites in the regulatory subunit of vascular calpain II. A comparison of partial amino-terminal sequences to deduced sequence from complementary DNA J Biol Chem (1989) 264, 17428-17431. PubMed Europe PubMed
Murachi,T. Intracellular regulatory system involving calpain and calpastatin Biochem Int (1989) 18, 263-294. PubMed Europe PubMed

1988

Crawford,C., Mason,R.W., Wikstrom,P. and Shaw,E. The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B Biochem J (1988) 253, 751-758. PubMed Europe PubMed PMC EPMC I
Imajoh,S., Aoki,K., Ohno,S., Emori,Y., Kawasaki,H., Sugihara,H. and Suzuki,K. Molecular cloning of the cDNA for the large subunit of the high- Ca2+-requiring form of human Ca2+-activated neutral protease Biochemistry (1988) 27, 8122-8128. PubMed Europe PubMed

1987

Crawford,C. Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha2-macroglobulin Biochem J (1987) 248, 589-594. PubMed Europe PubMed PMC EPMC I

1986

Glaser,T. and Kosower,N.S. Calpain-calpastatin and fusion. Fusibility of erythrocytes is determined by a protease-protease inhibitor [calpain-calpastatin] balance FEBS Lett (1986) 206, 115-120. PubMed Europe PubMed
Parkes,C., Kembhavi,A.A. and Barrett,A.J. Calpain inhibition by peptide epoxides and the effect of autolysis (1986) , 631-632. I
Sasaki,T., Kikuchi,T., Fukui,I. and Murachi,T. Inactivation of calpain I and calpain II by specificity-oriented tripeptidyl chloromethyl ketones J Biochem (1986) 99, 173-179. PubMed Europe PubMed I

1985

Hatanaka,M., Yumoto,N., Sakihama,T. and Murachi,T. Evidence for heterodimeric nature of calpain molecules as studied by cross-linking modification Biochem Int (1985) 10, 187-193. PubMed Europe PubMed
McDermott,J.R., Mantle,D., Biggins,J.A., Kidd,A.M., Davison,K., Lauffart,B. and Pennington,R.J. Specificity of neuropeptide degradation by two calcium-activated neutral proteases from human skeletal muscle Life Sci (1985) 37, 725-730. PubMed Europe PubMed DOI
Parkes,C., Kembhavi,A.A. and Barrett,A.J. Calpain inhibition by peptide epoxides Biochem J (1985) 230, 509-516. PubMed Europe PubMed PMC EPMC I
Sakamoto,S.-I., Yamada,Y. and Seki,N. Comparison of enzymatic properties of calpain II from carp and rabbit muscles Nippon Suisan Gakkaishi Jpn Ed (1985) 51, 825-831. DOI
Sakihama,T., Kakidani,H., Zenita,K., Yumoto,N., Kikuchi,T., Sasaki,T., Kannagi,R., Nakanishi,S., Ohmori,M., Takio,K., Titani,K. and Murachi,T. A putative Ca2+-binding protein: structure of the light subunit of porcine calpain elucidated by molecular cloning and protein sequence analysis Proc Natl Acad Sci U S A (1985) 82, 6075-6079. PubMed Europe PubMed PMC EPMC

1984

[YEAR:25-10-1984]Sasaki,T., Kikuchi,T., Yumoto,N., Yoshimura,N. and Murachi,T. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates J Biol Chem (25-10-1984) 259, 12489-12494. PubMed Europe PubMed
[YEAR:10-4-1984]Yoshida,H., Murachi,T. and Tsukahara,I. Limited proteolysis of bovine lens alpha-crystallin by calpain, a Ca2+-dependent cysteine proteinase, isolated from the same tissue Biochim Biophys Acta (10-4-1984) 798, 252-259. PubMed Europe PubMed DOI

1983

[YEAR:16-3-1983]Cottin,P., Vidalenc,P.L., Merdaci,N. and Ducastaing,A. Evidence for non-competitive inhibition between two calcium-dependent activated neutral proteinases and their specific inhibitor Biochim Biophys Acta (16-3-1983) 743, 299-302. PubMed Europe PubMed
[YEAR:14-1-1983]Sasaki,M., Taniguchi,K., Suzuki,K. and Imahori,K. Human plasma alpha 1- and alpha 2-thiol proteinase inhibitors strongly inhibit Ca-activated neutral protease from muscle Biochem Biophys Res Commun (14-1-1983) 110, 256-261. PubMed Europe PubMed
Suzuki,K., Hayashi,H., Hayashi,T. and Iwai,K. Amino acid sequence around the active site cysteine residue of calcium-activated neutral protease (CANP) FEBS Lett (1983) 152, 67-70. PubMed Europe PubMed
Suzuki,K. Reaction of calcium-activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid J Biochem (1983) 93, 1305-1312. PubMed Europe PubMed I
[YEAR:25-7-1983]Yoshimura,N., Kikuchi,T., Sasaki,T., Kitahara,A., Hatanaka,M. and Murachi,T. Two distinct Ca2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney J Biol Chem (25-7-1983) 258, 8883-8889. PubMed Europe PubMed

1982

[YEAR:20-12-1982]Dayton,W.R. Comparison of low- and high-calcium-requiring forms of the calcium-activated protease with their autocatalytic breakdown products Biochim Biophys Acta (20-12-1982) 709, 166-172. PubMed Europe PubMed
[YEAR:10-8-1982]Hathaway,D.R., Werth,D.K. and Haeberle,J.R. Limited autolysis reduces the Ca2+ requirement of a smooth muscle Ca2+-activated protease J Biol Chem (10-8-1982) 257, 9072-9077. PubMed Europe PubMed
[YEAR:25-6-1982]Mellgren,R.L., Repetti,A., Muck,T.C. and Easly,J. Rabbit skeletal muscle calcium-dependent protease requiring millimolar Ca2+. Purification, subunit structure, and Ca2+-dependent autoproteolysis J Biol Chem (25-6-1982) 257, 7203-7209. PubMed Europe PubMed

1981

Suzuki,K., Tsuji,S., Kubota,S., Kimura,Y. and Imahori,K. Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions J Biochem (1981) 90, 275-278. PubMed Europe PubMed
Suzuki,K., Tsuji,S. and Ishiura,S. Effect of Ca2+ on the inhibition of calcium-activated neutral protease by leupeptin, antipain and epoxysuccinate derivatives FEBS Lett (1981) 136, 119-122. PubMed Europe PubMed DOI I
Waxman,L. Calcium-activated proteases in mammalian tissues Methods Enzymol (1981) 80, 664-680. PubMed Europe PubMed DOI V

1980

[YEAR:1-1-1980]Mellgren,R.L. Canine cardiac calcium-dependent proteases: resolution of two forms with different requirements for calcium FEBS Lett (1-1-1980) 109, 129-133. PubMed Europe PubMed

1978

[YEAR:30-5-1978]Toyo-oka,T., Shimizu,T. and Masaki,T. Inhibition of proteolytic activity of calcium activated neutral protease by leupeptin and antipain Biochem Biophys Res Commun (30-5-1978) 82, 484-491. PubMed Europe PubMed I

1976

[YEAR:18-5-1976]Dayton,W.R., Goll,D.E., Zeece,M.G., Robson,R.M. and Reville,W.J. A Ca2+-activated protease possibly involved in myofibrillar protein turnover. Purification from porcine muscle Biochemistry (18-5-1976) 15, 2150-2158. PubMed Europe PubMed

1975

Reddy,M.K., Etlinger,J.D., Rabinowitz,M., Fischman,D.A. and Zak,R. Removal of Z-lines and alpha-actinin from isolated myofibrils by a calcium-activated neutral protease J Biol Chem (1975) 250, 4278-4284. PubMed Europe PubMed

1972

Busch,W.A., Stromer,M.H., Goll,D.E. and Suzuki,A. Ca2+-specific removal of Z-lines from rabbit skeletal muscle J Cell Biol (1972) 52, 367-381. PubMed Europe PubMed PMC EPMC