Literature for peptidase C02.001: calpain-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Awad,M.A., Gu,W., Li,S., Wei,Y., Tang,Y., Shi,Y., Juvenal,H., Jiang,Y., Liu,T., Shuai,L., Wang,Z., Wu,B., Zhou,X. and Tang,F. Calpain-1 is required for abnormality of liver function and metabolism in apolipoprotein E knockout mouse evaluated noninvasively by small animal MRI and PET-CT Biochim Biophys Acta Mol Cell Biol Lipids (2025) 1870, 159616-159616. PubMed Europe PubMed DOI
Chukai,Y., Furukawa,N., Kosegawa,O., Bai,L., Sugano,E., Fukuda,T., Tomita,H. and Ozaki,T. Mitochondrial calpain-1 truncates ATP synthase beta subunit Biochem Biophys Res Commun (2025) 765, 151829-151829. PubMed Europe PubMed DOI
Horbach,N., Kalinka,M., Cwilichowska-Puslecka,N., Al Mamun,A., Mikolajczyk-Martinez,A., Turk,B., Snipas,S.J., Kasperkiewicz,P., Groborz,K.M. and Poreba,M. Visualization of calpain-1 activation during cell death and its role in GSDMD cleavage using chemical probes Cell Chem Biol (2025) PubMed Europe PubMed DOI
Najdek,C., Walle,P., Flaig,A., Ayral,A.M., Demiautte,F., Coulon,A., Buiche,V., Lambert,E., Amouyel,P., Gelle,C., Siedlecki-Wullich,D., Dumont,J., Kilinc,D., Eysert,F., Lambert,J.C. and Chapuis,J. Calpain and caspase regulate Abeta peptide production via cleavage of KINDLIN2 encoded by the AD-associated gene FERMT2 Neurobiol Aging (2025) 151, 117-125. PubMed Europe PubMed DOI
Shi,Y., Gu,W., Wei,Y., Li,S., Zhang,S., Jiang,Y., Chen,C., Liu,T., Shuai,L., Zhou,X. and Tang,F. Deficiency of Calpain-1 attenuates atherosclerotic plaque and calcification and improves vasomotor dysfunction in Apolipoprotein E knockout mice through inhibiting inflammation Biochem Biophys Res Commun (2025) 749, 151369-151369. PubMed Europe PubMed DOI
Taylor,K.A., Elgheznawy,A., Adiyaman,R., Horn,T.L., Parkes,S., Hughes,C.E., McGuffin,L.J. and Gibbins,J.M. Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62 Haematologica (2025) PubMed Europe PubMed DOI
Wang,Y., Jiang,L., Li,Q., Li,M., Shi,W., Wang,B., Wang,G., Deng,G., Shi,J., Tian,G., Zeng,X., Chen,H. and Li,C. TRIM45 restricts influenza virus infection through modulating the chaperone-mediated autophagic degradation of viral PB2 protein PLoS Pathog (2025) 21, e1013630-e1013630. PubMed Europe PubMed DOI PMC EPMC

2024

Baudry,M. and Bi,X. Revisiting the calpain hypothesis of learning and memory 40 years later Front Mol Neurosci (2024) 17, 1337850-1337850. PubMed Europe PubMed DOI PMC EPMC V
Biswal,L., Sahu,V.K., Sardoiwala,M.N., Karmakar,S. and Choudhury,S.R. Antibody conjugated targeted nanotherapy epigenetically inhibits calpain-mediated mitochondrial dysfunction to attenuate Parkinson's disease Carbohydr Polym (2024) 346, 122575-122575. PubMed Europe PubMed DOI
Shu,J., Ma,X., Zou,J., Yuan,Z. and Yi,Z. Zika virus infection triggers caspase cleavage of STAT1 Microbiol Spectr (2024) 12, e0360923-e0360923. PubMed Europe PubMed DOI PMC EPMC
Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H. Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1 Signal Transduct Target Ther (2024) 9, 54-54. PubMed Europe PubMed DOI PMC EPMC I

2023

Berna-Erro,A., Ramesh,G., Delgado,E., Corbacho,A.J., Ferrer-Marin,F., Teruel,R., Granados,M.P., Rosado,J.A. and Redondo,P.C. CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets Arterioscler Thromb Vasc Biol (2023) 43, e151-e151. PubMed Europe PubMed DOI
Ojima,K., Hata,S., Shinkai-Ouchi,F., Ono,Y. and Muroya,S. Calpain-3 not only proteolyzes calpain-1 and -2 but also is a substrate for calpain-1 and -2 J Biochem (2023) 174, 421-431. PubMed Europe PubMed DOI
Quinn,J.P., Ethier,E.C., Novielli,A., Malone,A., Ramirez,C.E., Salloum,L., Trombetta,B.A., Kivisakk,P., Bremang,M., Selzer,S., Fournier,M., Das,S., Xing,Y., Arnold,S.E. and Carlyle,B.C. Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease J Am Soc Mass Spectrom (2023) 34, 649-667. PubMed Europe PubMed DOI PMC EPMC

2022

Bar,J., Popp,Y., Koudelka,T., Tholey,A. and Mikhaylova,M. Regulation of microtubule detyrosination by Ca2+ and conventional calpains J Cell Sci (2022) 135 PubMed Europe PubMed DOI
Chen,Q., Thompson,J., Hu,Y. and Lesnefsky,E.J. The mitochondrial electron transport chain contributes to calpain 1 activation during ischemia-reperfusion Biochem Biophys Res Commun (2022) 613, 127-132. PubMed Europe PubMed DOI
Miller,J.A., Drouet,D.E., Yermakov,L.M., Elbasiouny,M.S., Bensabeur,F.Z., Bottomley,M. and Susuki,K. Distinct Changes in Calpain and Calpastatin during PNS Myelination and Demyelination in Rodent Models Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC

2021

Knopp,R.C., Jastaniah,A., Dubrovskyi,O., Gaisina,I., Tai,L. and Thatcher,G.R.J. Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma ACS Pharmacol Transl Sci (2021) 4, 372-385. PubMed Europe PubMed DOI PMC EPMC
Saadane,A., Du,Y., Thoreson,W.B., Miyagi,M., Lessieur,E.M., Kiser,J., Wen,X., Berkowitz,B.A. and Kern,T.S. Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy Am J Pathol (2021) PubMed Europe PubMed DOI K
Wang,J., Ciampa,G., Zheng,D., Shi,Q., Chen,B., Abel,E.D., Peng,T., Hall,D.D. and Song,L.S. Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy Biochem J (2021) 478, 3539-3553. PubMed Europe PubMed DOI

2020

Asano,T., Nagayo,Y., Tsuda,S., Ito,A., Kobayashi,W., Fujita,K., Sato,K., Nishiguchi,K.M., Kunikata,H., Fujioka,H., Kamiya,M., Urano,Y. and Nakazawa,T. Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe Bioconjug Chem (2020) 31, 2241-2251. PubMed Europe PubMed DOI I
Baliova,M. and Jursky,F. Phosphorylation of serine 157 protects the rat glycine transporter GlyT2 from calpain cleavage J Mol Neurosci (2020) PubMed Europe PubMed DOI
Chang,Y.S., Wu,S.Y., Stromer,M.H. and Chou,R.R. Calpain activation and proteolysis in postmortem goose muscles Anim Sci J (2020) 91, e13423-e13423. PubMed Europe PubMed DOI
Dewitt,S. and Hallett,M.B. Calpain activation by Ca(2+) and its role in phagocytosis Adv Exp Med Biol (2020) 1246, 129-151. PubMed Europe PubMed DOI
Ding,Z., Wei,Q., Zhang,C., Zhang,H. and Huang,F. Influence of oxidation on heat shock protein 27 translocation, caspase-3 and calpain activities and myofibrils degradation in postmortem beef muscles Food Chem (2020) 340, 127914-127914. PubMed Europe PubMed DOI
Donkor,I.O., Xu,J., Liu,J. and Cameron,K. Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors Bioorg Med Chem (2020) , 115433-115433. PubMed Europe PubMed DOI I
Edwards,J.J., Brandimarto,J., Hu,D.Q., Jeong,S., Yucel,N., Li,L., Bedi,K.C., Jr., Wada,S., Murashige,D., Hwang,H.T.V., Zhao,M., Margulies,K.B., Bernstein,D., Reddy,S. and Arany,Z. Noncanonical WNT Activation in Human Right Ventricular Heart Failure Front Cardiovasc Med (2020) 7, 582407-582407. PubMed Europe PubMed DOI PMC EPMC
Goto,S., Ozaki,Y., Ozawa,F., Mizutani,E., Kitaori,T., Suzumori,N., Blomgren,K., Furuno,T. and Sugiura-Ogasawara,M. The investigation of calpain in human placenta with fetal growth restriction Am J Reprod Immunol (2020) , e13325-e13325. PubMed Europe PubMed DOI
Gritsyna,Y.V., Ulanova,A.D., Popova,S.S., Bobylev,A.G., Zhalimov,V.K., Nemirovskaya,T.L., Shenkman,B.S. and Vikhlyantsev,I.M. Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading Dokl Biochem Biophys (2020) 495, 338-341. PubMed Europe PubMed DOI
Hatta,D., Shirotani,K., Hori,Y., Kurotaki,N. and Iwata,N. Activity-dependent cleavage of dyskinesia-related proline-rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons FASEB J (2020) 34, 180-191. PubMed Europe PubMed DOI
Jastaniah,A., Gaisina,I.N., Knopp,R.C. and Thatcher,G.R.J. Synthesis of alpha-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents ChemMedChem (2020) PubMed Europe PubMed DOI I
Ko,Y.U., Song,H.Y., Kim,W.K., Yune,T.Y., Yun,N. and Oh,Y.J. Calpain-mediated cleavage of Fbxw7 during excitotoxicity Neurosci Lett (2020) 736, 135265-135265. PubMed Europe PubMed DOI I
Kyselova,A., Elgheznawy,A., Wittig,I., Heidler,J., Mann,A.W., Ruf,W., Fleming,I. and Randriamboavonjy,V. Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes Basic Res Cardiol (2020) 115, 75-75. PubMed Europe PubMed DOI PMC EPMC
Lakshmanan,A., Jin,Z., Nety,S.P., Sawyer,D.P., Lee-Gosselin,A., Malounda,D., Swift,M.B., Maresca,D. and Shapiro,M.G. Acoustic biosensors for ultrasound imaging of enzyme activity Nat Chem Biol (2020) PubMed Europe PubMed DOI
Lopatniuk,P., Puchalska,Z., Mital,A., Mikosik,A., Frackowiak,J., Hellmann,A., Daca,A., Bryl,E., Fulop,T. and Witkowski,J.M. Excessive amount and activity of mu-calpain affects apoptotic machinery in chronic B-cell leukemia cells and influences the course of the disease Acta Biochim Pol (2020) 67, 247-257. PubMed Europe PubMed DOI
Panico,P., Hiriart,M., Ostrosky-Wegman,P. and Salazar,A.M. TUG is a calpain-10 substrate involved in the translocation of GLUT4 in adipocytes J Mol Endocrinol (2020) 65, 45-57. PubMed Europe PubMed DOI
Wang,Y., Liu,Y., Bi,X. and Baudry,M. Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death Cells (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Weber,J.J., Haas,E., Maringer,Y., Hauser,S., Casadei,N.L.P., Chishti,A.H., Riess,O. and Hubener-Schmid,J. Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease Hum Mol Genet (2020) 29, 892-906. PubMed Europe PubMed DOI K
Yi,C., Wu,W., Zheng,D., Peng,G., Huang,H., Shen,Z. and Teng,X. Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis Cell Death Dis (2020) 11, 533-533. PubMed Europe PubMed DOI PMC EPMC

2019

Antoniades,I., Charalambous,A., Christodoulou,N., Zanardelli,S. and Skourides,P.A. Methods of calpain inhibition to determine the role of calpains in embryo development in amphibians Methods Mol Biol (2019) 1915, 249-259. PubMed Europe PubMed DOI
Baudry,M. Calpain-1 and calpain-2 in the brain: Dr. Jekill and Mr Hyde? Curr Neuropharmacol (2019) 17, 823-829. PubMed Europe PubMed DOI
Biswas,A.K. and Tandon,S. Casein zymography for analysis of calpain-1 and calpain-2 activity Methods Mol Biol (2019) 1915, 31-38. PubMed Europe PubMed DOI
Biswas,A.K. and Tandon,S. Single-step purification of calpain-1, calpain-2, and calpastatin using anion-exchange chromatography Methods Mol Biol (2019) 1915, 3-11. PubMed Europe PubMed DOI
Chaimon,S., Limpanont,Y., Reamtong,O., Ampawong,S., Phuphisut,O., Chusongsang,P., Ruangsittichai,J., Boonyuen,U., Watthanakulpanich,D., O'Donoghue,A.J., Caffrey,C.R. and Adisakwattana,P. Molecular characterization and functional analysis of the Schistosoma mekongi Ca(2+)-dependent cysteine protease (calpain) Parasit Vectors (2019) 12, 383-383. PubMed Europe PubMed DOI PMC EPMC
Cotti Piccinelli,S., Bassi,M.T., Citterio,A., Manganelli,F., Tozza,S., Santorelli,F.M., Gallo Cassarino,S., Caria,F., Baldelli,E., Galvagni,A., Santoro,L., Padovani,A. and Filosto,M. A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family Front Neurol (2019) 10, 580-580. PubMed Europe PubMed DOI PMC EPMC M
Davis,M.A., Fairgrieve,M.R., Den Hartigh,A., Yakovenko,O., Duvvuri,B., Lood,C., Thomas,W.E., Fink,S.L. and Gale M Jr Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation Proc Natl Acad Sci U S A (2019) 116, 5061-5070. PubMed Europe PubMed DOI
Del Carmen Lafita-Navarro,M. and Conacci-Sorrell,M. Identification of calpain-activated protein functions Methods Mol Biol (2019) 1915, 149-160. PubMed Europe PubMed DOI
Du,M., Li,X., Li,Z., Shen,Q., Ren,C. and Zhang,D. Calpastatin inhibits the activity of phosphorylated mu-calpain in vitro Food Chem (2019) 274, 743-749. PubMed Europe PubMed DOI
Duverle,D.A. and Mamitsuka,H. CalCleaveMKL: a tool for calpain cleavage prediction Methods Mol Biol (2019) 1915, 121-147. PubMed Europe PubMed DOI
Gao,Y., Hall,C., MacLeod,J. and Greer,P.A. Genetic models of calpain deficiency and ectopic expression Methods Mol Biol (2019) 1915, 261-274. PubMed Europe PubMed DOI K
Jantos,K., Kling,A., Mack,H., Hornberger,W., Moeller,A., Nimmrich,V., Lao,Y. and Nijsen,M. Discovery of ABT-957: 1-benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability Bioorg Med Chem Lett (2019) 29, 1968-1973. PubMed Europe PubMed DOI I
Jennings,S. and Hallett,M.B. Single cell measurement of calpain activity in neutrophils reveals link to cytosolic Ca(2+) elevation and individual phagocytotic events Biochem Biophys Res Commun (2019) 515, 163-168. PubMed Europe PubMed DOI L
Jiang,S., Shao,C., Tang,F., Wang,W. and Zhu,X. Dynamin-like protein 1 cleavage by calpain in Alzheimer's disease Aging Cell (2019) , e12912-e12912. PubMed Europe PubMed DOI I
Jin,S.W., Lee,G.H., Pham,H.T., Choi,J.H. and Jeong,H.G. Polyhexamethylene guanidine phosphate damages tight junctions and the F-actin architecture by activating calpain-1 via the P2RX7/Ca(2+) signaling pathway Cells (2019) 9 PubMed Europe PubMed DOI
Kitagawa,S. Experimental manipulation of calpain activity in vitro Methods Mol Biol (2019) 1915, 209-218. PubMed Europe PubMed DOI I
Liu,X. and Hu,G. In vivo calpain knockdown using delivery of siRNA Methods Mol Biol (2019) 1915, 219-232. PubMed Europe PubMed DOI K
Liu,Z.X., Yu,K., Dong,J., Zhao,L., Liu,Z., Zhang,Q., Li,S., Du,Y. and Cheng,H. Precise prediction of calpain cleavage sites and their aberrance caused by mutations in cancer Front Genet (2019) 10, 715-715. PubMed Europe PubMed DOI PMC EPMC P
Lostal,W., Stockholm,D. and Richard,I. In vivo monitoring of calpain activity by Forster resonance energy transfer Methods Mol Biol (2019) 1915, 57-66. PubMed Europe PubMed DOI L
Matos,A.M., Pinto,F.R., Barros,P., Amaral,M.D., Pepperkok,R. and Matos,P. Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant J Biol Chem (2019) 294, 13396-13410. PubMed Europe PubMed DOI
Ong,S.B., Lee,W.H., Shao,N.Y., Ismail,N.I., Katwadi,K., Lim,M.M., Kwek,X.Y., Michel,N.A., Li,J., Newson,J., Tahmasebi,S., Rehman,J., Kodo,K., Jang,H.R. and Ong,S.G. Calpain inhibition restores autophagy and prevents mitochondrial fragmentation in a human iPSC model of diabetic endotheliopathy Stem Cell Reports (2019) 12, 597-610. PubMed Europe PubMed DOI I
Shams,R., Banik,N.L. and Haque,A. Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease Prog Mol Biol Transl Sci (2019) 167, 107-124. PubMed Europe PubMed DOI
Wang,L., Zhang,C., Sun,S., Chen,Y., Hu,Y., Wang,H., Liu,M., Dong,N. and Wu,Q. Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells Biochem J (2019) 476, 2355-2369. PubMed Europe PubMed DOI

2018

Andersen,P.V., Wold,J.P. and Veiseth-Kent,E. Analyzing mu-Calpain induced proteolysis in a myofibril model system with vibrational and fluorescence spectroscopy Meat Sci (2018) 139, 239-246. PubMed Europe PubMed DOI
Aweida,D., Rudesky,I., Volodin,A., Shimko,E. and Cohen,S. GSK3-beta promotes calpain-1-mediated desmin filament depolymerization and myofibril loss in atrophy J Cell Biol (2018) 217, 3698-3714. PubMed Europe PubMed DOI
Becker,B., Nazir,F.H., Brinkmalm,G., Camporesi,E., Kvartsberg,H., Portelius,E., Bostrom,M., Kalm,M., Hoglund,K., Olsson,M., Zetterberg,H. and Blennow,K. Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by calpain-1 and prolyl endopeptidase Mol Neurodegener (2018) 13, 47-47. PubMed Europe PubMed DOI PMC EPMC
Chen,H.H., Liu,P., Auger,P., Lee,S.H., Adolfsson,O., Rey-Bellet,L., Lafrance-Vanasse,J., Friedman,B.A., Pihlgren,M., Muhs,A., Pfeifer,A., Ernst,J., Ayalon,G., Wildsmith,K.R., Beach,T.G. and van der Brug,M.P. Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression Sci Rep (2018) 8, 16725-16725. PubMed Europe PubMed DOI P
De Tullio,R., Franchi,A., Martines,A., Averna,M., Pedrazzi,M., Melloni,E. and Sparatore,B. Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain Biosci Rep (2018) 38, BSR20180147-BSR20180147. PubMed Europe PubMed DOI
Du,M., Li,X., Li,Z., Shen,Q., Wang,Y., Li,G. and Zhang,D. Phosphorylation regulated by protein kinase A and alkaline phosphatase play positive roles in mu-calpain activity Food Chem (2018) 252, 33-39. PubMed Europe PubMed DOI
Etwebi,Z., Landesberg,G., Preston,K., Eguchi,S. and Scalia,R. Mechanistic role of the calcium-dependent protease calpain in the endothelial dysfunction induced by MPO (myeloperoxidase) Hypertension (2018) 71, 761-770. PubMed Europe PubMed DOI K
Gutierrez,S., Moron,M., Griera,M., Sucunza,D., Calleros,L., Garcia-Jerez,A., Coderch,C., Hermoso,F.J., Burgos,C., Rodriguez-Puyol,M., de Pascual-Teresa,B., Diez-Marques,M.L., Jimenez,A., Toro-Londono,M., Rodriguez-Puyol,D. and Vaquero,J.J. Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold Eur J Med Chem (2018) 157, 946-959. PubMed Europe PubMed DOI I
Ishak,R. and Hallett,M.B. Defective rapid cell shape and transendothelial migration by calpain-1 null neutrophils Biochem Biophys Res Commun (2018) 506, 1065-1070. PubMed Europe PubMed DOI K
Kalash,L., Cresser-Brown,J., Habchi,J., Morgan,C., Miller,D.J., Glen,R.C., Allemann,R.K. and Bender,A. Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space Eur J Med Chem (2018) 157, 1264-1275. PubMed Europe PubMed DOI I
Kling,A., Jantos,K., Mack,H., Hornberger,W., Backfisch,G., Lao,Y., Nijsen,M., Rendenbach-Mueller,B. and Moeller,A. Mitigating the metabolic liability of carbonyl reduction: novel calpain inhibitors with P1' extension ACS Med Chem Lett (2018) 9, 221-226. PubMed Europe PubMed DOI PMC EPMC I
Leal-Gutierrez,J.D., Elzo,M.A., Johnson,D.D., Scheffler,T.L., Scheffler,J.M. and Mateescu,R.G. Association of mu-calpain and calpastatin polymorphisms with meat tenderness in a Brahman-Angus population Front Genet (2018) 9, 56-56. PubMed Europe PubMed DOI PMC EPMC M
MacLeod,J.A., Gao,Y., Hall,C., Muller,W.J., Gujral,T.S. and Greer,P.A. Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib Oncotarget (2018) 9, 33382-33395. PubMed Europe PubMed DOI PMC EPMC K I
Nowak,K., Taubert,R.M., Haberecht,S., Venz,S. and Kruger,E. Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasomal inhibition Biosci Rep (2018) 38, BSR20180393-BSR20180393. PubMed Europe PubMed DOI
Pahima,H., Reina,S., Tadmor,N., Dadon-Klein,D., Shteinfer-Kuzmine,A., Mazure,N.M., Pinto,V. and Shoshan-Barmatz,V. Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities Oncotarget (2018) 9, 12825-12841. PubMed Europe PubMed DOI PMC EPMC I
Salimi,R., Bandaru,S., Devarakonda,S., Gokalp,S., Ala,C., Alvandian,A., Yener,N. and Akyurek,L.M. Blocking the cleavage of filamin A by calpain inhibitor decreases tumor cell growth Anticancer Res (2018) 38, 2079-2085. PubMed Europe PubMed DOI I
Verheijden,K.A.T., Sonneveld,R., Bakker-van Bebber,M., Wetzels,J.F.M., van der Vlag,J. and Nijenhuis,T. The calcium-dependent protease calpain-1 links TRPC6 activity to podocyte injury J Am Soc Nephrol (2018) 29, 2099-2109. PubMed Europe PubMed DOI
Wang,Y., Liu,Y., Lopez,D., Lee,M., Dayal,S., Hurtado,A., Bi,X. and Baudry,M. Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice J Neurotrauma (2018) 35, 105-117. PubMed Europe PubMed DOI I
Wang,Y., Chen,B., Huang,C.K., Guo,A., Wu,J., Zhang,X., Chen,R., Chen,C., Kutschke,W., Weiss,R.M., Boudreau,R.L., Margulies,K.B., Hong,J. and Song,L.S. Targeting calpain for heart failure therapy: implications from multiple murine models JACC Basic Transl Sci (2018) 3, 503-517. PubMed Europe PubMed DOI PMC EPMC I

2017

Du,M., Li,X., Li,Z., Li,M., Gao,L. and Zhang,D. Phosphorylation inhibits the activity of mu-calpain at different incubation temperatures and Ca2+ concentrations in vitro Food Chem (2017) 228, 649-655. PubMed Europe PubMed DOI
Du,M., Li,X., Li,Z., Shen,Q., Wang,Y., Li,G. and Zhang,D. Effects of phosphorylation on mu-calpain activity at different incubation temperature Food Res Int (2017) 100, 318-324. PubMed Europe PubMed DOI
Ferreras,S., Fernandez,G., Danelon,V., Pisano,M.V., Masseroni,L., Chapleau,C.A., Krapacher,F.A., Mlewski,E.C., Masco,D.H., Arias,C., Pozzo-Miller,L. and Paglini,M.G. Cdk5 is essential for amphetamine to increase dendritic spine density in hippocampal pyramidal neurons Front Cell Neurosci (2017) 11, 372-372. PubMed Europe PubMed DOI PMC EPMC I
Hsu,C.Y., Gasc,G., Raymond,A.A., Burlet-Schiltz,O., Takahara,H., Serre,G., Mechin,M.C. and Simon,M. Deimination of human hornerin enhances its processing by calpain-1 and its cross-linking by transglutaminases J Invest Dermatol (2017) 137, 422-429. PubMed Europe PubMed DOI
Kerstein,P.C., Patel,K.M. and Gomez,T.M. Calpain-mediated proteolysis of talin and FAK regulates adhesion dynamics necessary for axon guidance J Neurosci (2017) 37, 1568-1580. PubMed Europe PubMed DOI
Kling,A., Jantos,K., Mack,H., Hornberger,W., Drescher,K., Nimmrich,V., Relo,A., Wicke,K., Hutchins,C.W., Lao,Y., Marsh,K. and Moeller,A. Discovery of novel and highly selective inhibitors of calpain for the treatment of Alzheimer's disease: 2-(3-phenyl-1H-pyrazol-1-yl)-nicotinamides J Med Chem (2017) 60, 7123-7138. PubMed Europe PubMed DOI I
Li,J., Yang,S. and Zhu,G. Postnatal calpain inhibition elicits cerebellar cell death and motor dysfunction Oncotarget (2017) 8, 87997-88007. PubMed Europe PubMed DOI PMC EPMC I
Li,Z., Li,X., Gao,X., Shen,Q.W., Du,M. and Zhang,D. Phosphorylation prevents in vitro myofibrillar proteins degradation by mu-calpain Food Chem (2017) 218, 455-462. PubMed Europe PubMed DOI
Li,Z., Li,X., Gao,X., Du,M. and Zhang,D. Effect of inhibition of mu-calpain on the myofibril structure and myofibrillar protein degradation in postmortem ovine muscle J Sci Food Agric (2017) 97, 2122-2131. PubMed Europe PubMed DOI I
Lin,X.Y. and Chen,S.Z. Calpain inhibitors ameliorate muscle wasting in a cachectic mouse model bearing CT26 colorectal adenocarcinoma Oncol Rep (2017) 37, 1601-1610. PubMed Europe PubMed DOI I
Liu,W., Ma,K., Kwon,S.H., Garg,R., Patta,Y.R., Fujiwara,T. and Gurtner,G.C. The abnormal architecture of healed diabetic ulcers is the result of FAK degradation by calpain 1 J Invest Dermatol (2017) 137, 1155-1165. PubMed Europe PubMed DOI
McCartney,C.E., MacLeod,J.A., Greer,P.A. and Davies,P.L. An easy-to-use FRET protein substrate to detect calpain cleavage in vitro and in vivo Biochim Biophys Acta (2017) 1865, 221-230. PubMed Europe PubMed DOI A
Nagayoshi,T., Isoda,K., Mamiya,N. and Kida,S. Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory Mol Brain (2017) 10, 61-61. PubMed Europe PubMed DOI PMC EPMC I
Plantier,V. and Brocard,F. [Calpain as a new therapeutic target for treating spasticity after a spinal cord injury] Med Sci (Paris) (2017) 33, 629-636. PubMed Europe PubMed DOI T
Randriamboavonjy,V., Kyselova,A., Elgheznawy,A., Zukunft,S., Wittig,I. and Fleming,I. Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice Basic Res Cardiol (2017) 112, 10-10. PubMed Europe PubMed DOI K
Tan,W.J., Tan,Q.Y., Wang,T., Lian,M., Zhang,L. and Cheng,Z.S. Calpain 1 regulates TGF-beta1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway Am J Transl Res (2017) 9, 1402-1409. PubMed Europe PubMed PMC EPMC I
Weber,J.J., Golla,M., Guaitoli,G., Wanichawan,P., Hayer,S.N., Hauser,S., Krahl,A.C., Nagel,M., Samer,S., Aronica,E., Carlson,C.R., Schols,L., Riess,O., Gloeckner,C.J., Nguyen,H.P. and Hubener-Schmid,J. A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3 Brain (2017) 140, 1280-1299. PubMed Europe PubMed DOI P
Yuan,X.C., Wu,C.H., Gao,F., Li,H.P., Xiang,H.C., Zhu,H., Pan,X.L., Lin,L.X., Liu,Y.S., Yu,W., Tian,B., Meng,X.F. and Li,M. Activation and expression of mu-calpain in dorsal root contributes to RTX-induced mechanical allodynia Mol Pain (2017) 13, 1744806917719169-1744806917719169. PubMed Europe PubMed DOI I
Zhu,G., Briz,V., Seinfeld,J., Liu,Y., Bi,X. and Baudry,M. Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction Sci Rep (2017) 7, 42788-42788. PubMed Europe PubMed DOI PMC EPMC K

2016

Baudry,M. and Bi,X. Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration Trends Neurosci (2016) 39, 235-245. PubMed Europe PubMed DOI
Bi,W., Jang,G.F., Zhang,L., Crabb,J.W., Laird,J., Linetsky,M. and Salomon,R.G. Molecular structures of isolevuglandin-protein cross-links Chem Res Toxicol (2016) 29, 1628-1640. PubMed Europe PubMed DOI I
Blanc,F., Furio,L., Moisy,D., Yen,H.L., Chignard,M., Letavernier,E., Naffakh,N., Mok,C.K. and Si-Tahar,M. Targeting host calpain proteases decreases influenza A virus infection Am J Physiol Lung Cell Mol Physiol (2016) 310, L689-L699. PubMed Europe PubMed DOI
Fa,M., Zhang,H., Staniszewski,A., Saeed,F., Shen,L.W., Schiefer,I.T., Siklos,M.I., Tapadar,S., Litosh,V.A., Libien,J., Petukhov,P.A., Teich,A.F., Thatcher,G.R. and Arancio,O. Novel selective calpain 1 inhibitors as potential therapeutics in Alzheimer's disease J Alzheimers Dis (2016) 49, 707-721. PubMed Europe PubMed DOI I
Gan-Or,Z., Bouslam,N., Birouk,N., Lissouba,A., Chambers,D.B., Veriepe,J., Androschuck,A., Laurent,S.B., Rochefort,D., Spiegelman,D., Dionne-Laporte,A., Szuto,A., Liao,M., Figlewicz,D.A., Bouhouche,A., Benomar,A., Yahyaoui,M., Ouazzani,R., Yoon,G., Dupre,N., Suchowersky,O., Bolduc,F.V., Parker,J.A., Dion,P.A., Drapeau,P., Rouleau,G.A. and Bencheikh,B.O. Mutations in CAPN1 cause autosomal-recessive hereditary spastic paraplegia Am J Hum Genet (2016) 98, 1038-1046. PubMed Europe PubMed DOI PMC EPMC M
Gan-Or,Z. and Rouleau,G.A. Calpain 1 in neurodegeneration: a therapeutic target? Lancet Neurol (2016) 15, 1118-1118. PubMed Europe PubMed DOI M T
Hudson,I.L., Leemaqz,S.Y., Neffe,A.T. and Abell,A.D. Classifying calpain inhibitors for the treatment of cataracts: A self organising map (SOM) ANN/KM approach in drug discovery Stud Comput Intell (2016) 628, 161-212. DOI I
Ji,J., Su,L. and Liu,Z. Critical role of calpain in inflammation Biomed Rep (2016) 5, 647-652. PubMed Europe PubMed DOI PMC EPMC V
Kumar,P., Choonara,Y.E. and Pillay,V. In silico affinity profiling of neuroactive polyphenols for post-traumatic calpain inactivation: a molecular docking and atomistic simulation sensitivity analysis Molecules (2016) 20, 135-168. PubMed Europe PubMed DOI I
Lamothe,S.M., Guo,J., Li,W., Yang,T. and Zhang,S. The human ether-a-go-go-related gene (hERG) potassium channel represents an unusual target for protease-mediated damage J Biol Chem (2016) 291, 20387-20401. PubMed Europe PubMed DOI
Lu,Y.M., Gao,Y.P., Tao,R.R., Liao,M.H., Huang,J.Y., Wu,G., Han,F. and Li,X.M. Calpain-dependent ErbB4 cleavage is involved in brain ischemia-induced neuronal death Mol Neurobiol (2016) 53, 2600-2609. PubMed Europe PubMed DOI
Ni,R., Zheng,D., Xiong,S., Hill,D.J., Sun,T., Gardiner,R.B., Fan,G.C., Lu,Y., Abel,E.D., Greer,P.A. and Peng,T. Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts: a novel mechanism contributing to diabetic cardiomyopathy Diabetes (2016) 65, 255-268. PubMed Europe PubMed DOI
Nwankwo,J.O., Lei,J., Xu,J., Rivera,A., Gupta,K. and Chishti,A.H. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease Haematologica (2016) 101, e397-e397. PubMed Europe PubMed DOI
Saito,M., Suzuki,Y., Yano,S., Miyazaki,T. and Sato,Y. Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells J Biochem (2016) 160, 227-232. PubMed Europe PubMed DOI
Seinfeld,J., Baudry,N., Xu,X., Bi,X. and Baudry,M. Differential activation of calpain-1 and calpain-2 following kainate-induced seizure activity in rats and mice eNeuro (2016) 3 PubMed Europe PubMed DOI PMC EPMC
Shinkai-Ouchi,F., Koyama,S., Ono,Y., Hata,S., Ojima,K., Shindo,M., duVerle,D., Ueno,M., Kitamura,F., Doi,N., Takigawa,I., Mamitsuka,H. and Sorimachi,H. Predictions of cleavability of calpain proteolysis by quantitative structure-activity relationship analysis using newly determined cleavage sites and catalytic efficiencies of an oligopeptide array Mol Cell Proteomics (2016) 15, 1262-1280. PubMed Europe PubMed DOI P
Thompson,J., Hu,Y., Lesnefsky,E.J. and Chen,Q. Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release Am J Physiol Heart Circ Physiol (2016) 310, H376-H384. PubMed Europe PubMed DOI I
Wan,F., Letavernier,E., Abid,S., Houssaini,A., Czibik,G., Marcos,E., Rideau,D., Parpaleix,A., Lipskaia,L., Amsellem,V., Gellen,B., Sawaki,D., Derumeaux,G., Dubois-Rande,J.L., Delcroix,M., Quarck,R., Baud,L. and Adnot,S. Extracellular calpain/calpastatin balance is involved in the progression of pulmonary hypertension Am J Respir Cell Mol Biol (2016) 55, 337-351. PubMed Europe PubMed DOI I
Wang,Y., Lopez,D., Davey,P.G., Cameron,D.J., Nguyen,K., Tran,J., Marquez,E., Liu,Y., Bi,X. and Baudry,M. Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury Neurobiol Dis (2016) 93, 121-128. PubMed Europe PubMed DOI I
Zhang,J.N., Michel,U., Lenz,C., Friedel,C.C., Koster,S., d'Hedouville,Z., Tonges,L., Urlaub,H., Bahr,M., Lingor,P. and Koch,J.C. Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration Sci Rep (2016) 6, 37050-37050. PubMed Europe PubMed DOI I

2015

Adams,S.E., Robinson,E.J., Miller,D.J., Rizkallah,P.J., Hallett,M.B. and Allemann,R.K. Conformationally restricted calpain inhibitors Chem Sci (2015) 6, 6865-6871. PubMed Europe PubMed DOI I
Averna,M., De Tullio,R., Pedrazzi,M., Bavestrello,M., Pellegrini,M., Salamino,F., Pontremoli,S. and Melloni,E. Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease PLoS ONE (2015) 10, e0116738-e0116738. PubMed Europe PubMed DOI PMC EPMC
Averna,M., Pellegrini,M., Cervetto,C., Pedrazzi,M., Bavestrello,M., De Tullio,R., Salamino,F., Pontremoli,S. and Melloni,E. Physiological roles of calpain 1 associated to multiprotein NMDA receptor complex PLoS ONE (2015) 10, e0139750-e0139750. PubMed Europe PubMed DOI PMC EPMC
Cagmat,E.B., Guingab-Cagmat,J.D., Vakulenko,V., Hayes,R.L. and Anagli,J. Potential use of calpain inhibitors as brain injury therapy (2015) PubMed Europe PubMed I
Campbell,J.S. and Hallett,M.B. Active calpain in phagocytically competent human neutrophils: electroinjection of fluorogenic calpain substrate Biochem Biophys Res Commun (2015) 457, 341-346. PubMed Europe PubMed DOI L
Cheng,Z., Jiang,X., Pansuria,M., Fang,P., Mai,J., Mallilankaraman,K., Gandhirajan,R.K., Eguchi,S., Scalia,R., Madesh,M., Yang,X. and Wang,H. Hyperhomocysteinemia and hyperglycemia induce and potentiate endothelial dysfunction via mu-calpain activation Diabetes (2015) 64, 947-959. PubMed Europe PubMed DOI K
Chimura,T., Launey,T. and Yoshida,N. Calpain-mediated degradation of drebrin by excitotoxicity in vitro and in vivo PLoS ONE (2015) 10, e0125119- PubMed Europe PubMed DOI I
Cho,K., Cho,M.H., Seo,J.H., Peak,J., Kong,K.H., Yoon,S.Y. and Kim,D.H. Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease Aging Cell (2015) 14, 878-886. PubMed Europe PubMed DOI
Donkor,I.O. An updated patent review of calpain inhibitors (2012 - 2014) Expert Opin Ther Pat (2015) 25, 17-31. PubMed Europe PubMed DOI I
Elgheznawy,A., Shi,L., Hu,J., Wittig,I., Laban,H., Pircher,J., Mann,A., Provost,P., Randriamboavonjy,V. and Fleming,I. Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes Circ Res (2015) 117, 157-165. PubMed Europe PubMed DOI I
Jin,N., Yin,X., Gu,J., Zhang,X., Shi,J., Qian,W., Ji,Y., Cao,M., Gu,X., Ding,F., Iqbal,K., Gong,C.X. and Liu,F. Truncation and activation of dual specificity tyrosine phosphorylation-regulated kinase 1A by calpain I: a molecular mechanism linked to tau pathology in Alzheimer disease J Biol Chem (2015) 290, 15219-15237. PubMed Europe PubMed DOI
Jin,N., Yin,X., Yu,D., Cao,M., Gong,C.X., Iqbal,K., Ding,F., Gu,X. and Liu,F. Truncation and activation of GSK-3beta by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease Sci Rep (2015) 5, 8187-8187. PubMed Europe PubMed DOI
Kishore,R., Benedict,C. and Cheng,Z. mu-Calpain as a novel target for impairment of nitric oxide-mediated vascular relaxation in diabetes: a mini review J Mol Genet Med (2015) 9 PubMed Europe PubMed DOI PMC EPMC
Lazzara,C.A., Riley,R.R., Rane,A., Andersen,J.K. and Kim,Y.H. The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: relevance for Parkinsons disease therapy Brain Res (2015) 1622, 127-136. PubMed Europe PubMed DOI
Li,F.Z., Cai,P.C., Song,L.J., Zhou,L.L., Zhang,Q., Rao,S.S., Xia,Y., Xiang,F., Xin,J.B., Greer,P.A., Shi,H.Z., Su,Y., Ma,W.L. and Ye,H. Crosstalk between calpain activation and TGF-beta1 augments collagen-I synthesis in pulmonary fibrosis Biochim Biophys Acta (2015) 1852, 1796-1804. PubMed Europe PubMed DOI K
Lu,L., Meehan,M.J., Gu,S., Chen,Z., Zhang,W., Zhang,G., Liu,L., Huang,X., Dorrestein,P.C., Xu,Y., Moore,B.S. and Qian,P.Y. Mechanism of action of thalassospiramides, a new class of calpain inhibitors Sci Rep (2015) 5, 8783-8783. PubMed Europe PubMed DOI PMC EPMC I
Luo,T., Yue,R., Hu,H., Zhou,Z., Yiu,K.H., Zhang,S., Xu,L., Li,K. and Yu,Z. PD150606 protects against ischemia/reperfusion injury by preventing mu-calpain-induced mitochondrial apoptosis Arch Biochem Biophys (2015) 586, 1-9. PubMed Europe PubMed DOI I
Menzies,F.M., Garcia-Arencibia,M., Imarisio,S., O'Sullivan,N.C., Ricketts,T., Kent,B.A., Rao,M.V., Lam,W., Green-Thompson,Z.W., Nixon,R.A., Saksida,L.M., Bussey,T.J., O'Kane,C.J. and Rubinsztein,D.C. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity Cell Death Differ (2015) 22, 433-444. PubMed Europe PubMed DOI
Muralidharan,A.R., Selvaraj,C., Singh,S.K., Sheu,J.R., Thomas,P.A. and Geraldine,P. Structure-based virtual screening and biological evaluation of a calpain inhibitor for prevention of selenite-induced cataractogenesis in an in vitro system J Chem Inf Model (2015) 55, 1686-1697. PubMed Europe PubMed DOI I
Prins,D. and Michalak,M. STIM1 is cleaved by calpain FEBS Lett (2015) 589, 3294-3301. PubMed Europe PubMed DOI
Shu,J.T., Zhang,M., Shan,Y.J., Xu,W.J., Chen,K.W. and Li,H.F. Analysis of the genetic effects of CAPN1 gene polymorphisms on chicken meat tenderness Genet Mol Res (2015) 14, 1393-1403. PubMed Europe PubMed DOI M
Wang,W., Zhang,F., Li,L., Tang,F., Siedlak,S.L., Fujioka,H., Liu,Y., Su,B., Pi,Y. and Wang,X. Mfn2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons J Biol Chem (2015) 290, 168-182. PubMed Europe PubMed DOI T
Wijnker,P.J., Li,Y., Zhang,P., Foster,D.B., Remedios,C.D., Van Eyk,J.E., Stienen,G.J., Murphy,A.M. and van der Velden,J. A novel phosphorylation site, serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis J Mol Cell Cardiol (2015) 82, 93-103. PubMed Europe PubMed DOI
Zheng,D., Wang,G., Li,S., Fan,G.C. and Peng,T. Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation Biochim Biophys Acta (2015) 1852, 882-892. PubMed Europe PubMed DOI

2014

Adams,S.E., Rizkallah,P.J., Miller,D.J., Robinson,E.J., Hallett,M.B. and Allemann,R.K. The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids J Struct Biol (2014) 187, 236-241. PubMed Europe PubMed DOI S I
Atherton,J., Kurbatskaya,K., Bondulich,M., Croft,C.L., Garwood,C.J., Chhabra,R., Wray,S., Jeromin,A., Hanger,D.P. and Noble,W. Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Abeta in Alzheimer's disease Aging Cell (2014) 13, 49-59. PubMed Europe PubMed DOI
Chai,H.H., Lim,D., Lee,S.H., Chai,H.Y. and Jung,E. Homology modeling study of bovine mu-calpain inhibitor-binding domains Int J Mol Sci (2014) 15, 7897-7938. PubMed Europe PubMed DOI
Chai,H.H., Lim,D., Jung,E., Choi,B.H. and Cho,Y.M. Understanding the interaction determinants of CAPN1 inhibition by CAST4 from bovines using molecular modeling techniques Molecules (2014) 19, 14316-14351. PubMed Europe PubMed DOI
Chung,H., Shin,S. and Chung,E. Effects of genetic variants for the bovine calpain gene on meat tenderness Mol Biol Rep (2014) 41, 2963-2970. PubMed Europe PubMed DOI M
Kanzaki,K., Kuratani,M., Matsunaga,S., Yanaka,N. and Wada,M. Three calpain isoforms are autolyzed in rat fast-twitch muscle after eccentric contractions J Muscle Res Cell Motil (2014) 35, 179-189. PubMed Europe PubMed DOI
Kim,H., Kang,A.-Y., Ko,A.-R., Park,H.C., So,I., Park,J.H., Cheong,H.I., Hwang,Y.-H. and Ahn,C. Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations Exp Cell Res (2014) 320, 62-68. PubMed Europe PubMed DOI
Lewis,K.J., Masterman,B., Laffafian,I., Dewitt,S., Campbell,J.S. and Hallett,M.B. Minimal impact electro-injection of cells undergoing dynamic shape change reveals calpain activation Biochim Biophys Acta (2014) 1843, 1182-1187. PubMed Europe PubMed DOI
Li,X., Luo,R., Chen,R., Song,L., Zhang,S., Hua,W. and Chen,H. Cleavage of IkappaBalpha by calpain induces myocardial NF-kappaB activation, TNF-alpha expression, and cardiac dysfunction in septic mice Am J Physiol Heart Circ Physiol (2014) 306, H833-H843. PubMed Europe PubMed DOI I
Low,K.E., Karunan Partha,S., Davies,P.L. and Campbell,R.L. Allosteric inhibitors of calpains: reevaluating inhibition by PD150606 and LSEAL Biochim Biophys Acta (2014) 1840, 3367-3373. PubMed Europe PubMed DOI I
Miners,J., Renfrew,R., Swirski,M. and Love,S. Accumulation of alpha-synuclein in dementia with Lewy bodies is associated with decline in the alpha-synuclein-degrading enzymes kallikrein-6 and calpain-1 Acta Neuropathol Commun (2014) 2, 164-164. PubMed Europe PubMed DOI
Mohrhauser,D.A., Lonergan,S.M., Huff-Lonergan,E., Underwood,K.R. and Weaver,A.D. Calpain-1 activity in bovine muscle is primarily influenced by temperature, not pH decline J Anim Sci (2014) 92, 1261-1270. PubMed Europe PubMed DOI
Nabeshima,Y., Washida,M., Tamura,M., Maeno,A., Ohnishi,M., Shiroishi,T., Imura,A., Razzaque,M.S. and Nabeshima,Y. Calpain 1 inhibitor BDA-410 ameliorates alpha-klotho-deficiency phenotypes resembling human aging-related syndromes Sci Rep (2014) 4, 5847-5847. PubMed Europe PubMed DOI I
Pawlinski,R. Inhibit the calpain to climb the mountain Blood (2014) 123, 1123-1124. PubMed Europe PubMed DOI PMC EPMC
Piatkov,K.I., Oh,J.H., Liu,Y. and Varshavsky,A. Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway Proc Natl Acad Sci U S A (2014) 111, E817-E826. PubMed Europe PubMed DOI
Stifanese,R., Averna,M., De Tullio,R., Pedrazzi,M., Milanese,M., Bonifacino,T., Bonanno,G., Salamino,F., Pontremoli,S. and Melloni,E. Role of calpain-1 in the early phase of experimental ALS Arch Biochem Biophys (2014) 562, 1-8. PubMed Europe PubMed DOI
Tyagi,T., Ahmad,S., Gupta,N., Sahu,A., Ahmad,Y., Nair,V., Chatterjee,T., Bajaj,N., Sengupta,S., Ganju,L., Singh,S.B. and Ashraf,M.Z. Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype Blood (2014) 123, 1250-1260. PubMed Europe PubMed DOI
Wu,C.Y., Chen,B., Jiang,Y.P., Jia,Z., Martin,D.W., Liu,S., Entcheva,E., Song,L.S. and Lin,R.Z. Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure J Am Heart Assoc (2014) 3, e000527-e000527. PubMed Europe PubMed DOI
Wu,Z., Chen,X., Liu,F., Chen,W., Wu,P., Wieschhaus,A.J., Chishti,A.H., Roche,P.A., Chen,W.M. and Lin,T.J. Calpain-1 contributes to IgE-mediated mast cell activation J Immunol (2014) 192, 5130-5139. PubMed Europe PubMed DOI
Yamashita,T. and Kwak,S. [Calpain plays a crucial role in TDP-43 pathology] Rinsho Shinkeigaku (2014) 54, 1151-1154. PubMed Europe PubMed DOI
Zheng,X., Zhou,A.X., Rouhi,P., Uramoto,H., Boren,J., Cao,Y., Pereira,T., Akyurek,L.M. and Poellinger,L. Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response Proc Natl Acad Sci U S A (2014) 111, 2560-2565. PubMed Europe PubMed DOI

2013

Amini,M., Ma,C.L., Farazifard,R., Zhu,G., Zhang,Y., Vanderluit,J., Zoltewicz,J.S., Hage,F., Savitt,J.M., Lagace,D.C., Slack,R.S., Beique,J.C., Baudry,M., Greer,P.A., Bergeron,R. and Park,D.S. Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury J Neurosci (2013) 33, 5773-5784. PubMed Europe PubMed DOI K
Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y. Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors Bioorg Chem (2013) 51, 24-30. PubMed Europe PubMed DOI I
Baudry,M., Chou,M.M. and Bi,X. Targeting calpain in synaptic plasticity Expert Opin Ther Targets (2013) 17, 579-592. PubMed Europe PubMed DOI V
Cataldo,F., Peche,L.Y., Klaric,E., Brancolini,C., Myers,M.P., Demarchi,F. and Schneider,C. CAPNS1 regulates USP1 stability and maintenance of genome integrity Mol Cell Biol (2013) 33, 2485-2496. PubMed Europe PubMed DOI
Clinkinbeard,T., Ghoshal,S., Craddock,S., Creed Pettigrew,L. and Guttmann,R.P. Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion Brain Res (2013) 1499, 129-135. PubMed Europe PubMed DOI
De Franceschi,L., Franco,R.S., Bertoldi,M., Brugnara,C., Matte,A., Siciliano,A., Wieschhaus,A.J., Chishti,A.H. and Joiner,C.H. Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease FASEB J (2013) 27, 750-759. PubMed Europe PubMed DOI I
Escalante,A.M., McGrath,R.T., Karolak,M.R., Dorr,R.T., Lynch,R.M. and Landowski,T.H. Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo Cancer Chemother Pharmacol (2013) 71, 1567-1576. PubMed Europe PubMed DOI I
Feng,Y., Xia,Y., Yu,G., Shu,X., Ge,H., Zeng,K., Wang,J. and Wang,X. Cleavage of GSK-3beta by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3beta activity induced by H2 O2 J Neurochem (2013) 126, 234-242. PubMed Europe PubMed DOI
Forman,O.P., De Risio,L. and Mellersh,C.S. Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell terrier dog breed PLoS ONE (2013) 8, e64627-e64627. PubMed Europe PubMed DOI PMC EPMC M
Hata,S., Kitamura,F. and Sorimachi,H. Efficient expression and purification of recombinant human mu-calpain using an Escherichia coli expression system Genes Cells (2013) 18, 753-763. PubMed Europe PubMed DOI E
Ishii,Y., Shintani-Ishida,K. and Yoshida,K. Connexin-43 hemichannels contribute to the propagation of mu-calpain-mediated neuronal death in a cortical ablation injury model Biochem Biophys Res Commun (2013) 441, 457-462. PubMed Europe PubMed DOI
Kemp,C.M., Oliver,W.T., Wheeler,T.L., Chishti,A.H. and Koohmaraie,M. The effects of Capn1 gene inactivation on skeletal muscle growth, development, and atrophy, and the compensatory role of other proteolytic systems J Anim Sci (2013) 91, 3155-3167. PubMed Europe PubMed DOI K
Miller,D.J., Adams,S.E., Hallett,M.B. and Allemann,R.K. Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future? Future Med Chem (2013) 5, 2057-2074. PubMed Europe PubMed DOI I
Ozaki,T., Ishiguro,S., Hirano,S., Baba,A., Yamashita,T., Tomita,H. and Nakazawa,M. Inhibitory peptide of mitochondrial mu-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats PLoS ONE (2013) 8, e71650-e71650. PubMed Europe PubMed DOI PMC EPMC I
Schiefer,I.T., Tapadar,S., Litosh,V., Siklos,M., Scism,R., Wijewickrama,G.T., Chandrasena,E.P., Sinha,V., Tavassoli,E., Brunsteiner,M., Fa',M., Arancio,O., Petukhov,P. and Thatcher,G.R. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors J Med Chem (2013) 56, 6054-6068. PubMed Europe PubMed DOI I
Sorrentino,V. A proteolytic cleavage to separate the sarcolemma/T-tubule from the sarcoplasmic reticulum J Physiol (2013) 591, 601-601. PubMed Europe PubMed DOI
Subramanian,V., Moorleghen,J.J., Balakrishnan,A., Howatt,D.A., Chishti,A.H. and Uchida,H.A. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice PLoS ONE (2013) 8, e72214-e72214. PubMed Europe PubMed DOI PMC EPMC I
Van Ba,H. and Inho,H. Significant role of mu-calpain (CANP1) in proliferation/survival of bovine skeletal muscle satellite cells In Vitro Cell Dev Biol Anim (2013) 49, 785-797. PubMed Europe PubMed DOI
Villalpando Rodriguez,G.E. and Torriglia,A. Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2 Biochim Biophys Acta (2013) 1833, 2244-2253. PubMed Europe PubMed DOI
Wang,Y., Briz,V., Chishti,A., Bi,X. and Baudry,M. Distinct roles for mu-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration J Neurosci (2013) 33, 18880-18892. PubMed Europe PubMed DOI
Yu,C.G., Li,Y., Raza,K., Yu,X.X., Ghoshal,S. and Geddes,J.W. Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats J Neurotrauma (2013) 30, 427-433. PubMed Europe PubMed DOI K

2012

Adams,S.E., Parr,C., Miller,D.J., Allemann,R.K. and Hallett,M.B. Potent inhibition of Ca2+-dependent activation of calpain-1 by novel mercaptoacrylates MedChemComm (2012) 3, 566-570. DOI I
Buddhala,C., Suarez,M., Modi,J., Prentice,H., Ma,Z., Tao,R. and Wu,J.Y. Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission PLoS ONE (2012) 7, e33002-e33002. PubMed Europe PubMed DOI PMC EPMC
Hnatowich,M., Le,H.D., Demoissac,D., Ranson,K., Yurkov,V., Gilchrist,J.S., Omelchenko,A. and Hryshko,L.V. mu-Calpain-mediated deregulation of cardiac, brain, and kidney NCX1 splice variants Cell Calcium (2012) 51, 164-170. PubMed Europe PubMed DOI
Kuchay,S.M., Wieschhaus,A.J., Marinkovic,M., Herman,I.M. and Chishti,A.H. Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading J Thromb Haemost (2012) 10, 1120-1132. PubMed Europe PubMed DOI
Liang,J.L., Cha,H.C., Lee,S.H., Son,J.K., Chang,H.W., Eom,J.E., Kwon,Y. and Jahng,Y. A facile synthesis of emodin derivatives, emodin carbaldehyde, citreorosein, and their 10-deoxygenated derivatives and their inhibitory activities on mu-calpain Arch Pharm Res (2012) 35, 447-454. PubMed Europe PubMed DOI I
McRobert,E.A., Young,A.N. and Bach,L.A. Advanced glycation end-products induce calpain-mediated degradation of ezrin FEBS J (2012) 279, 3240-3250. PubMed Europe PubMed DOI
Ozaki,T., Nakazawa,M., Yamashita,T., Sorimachi,H., Hata,S., Tomita,H., Isago,H., Baba,A. and Ishiguro,S. Intravitreal injection or topical eye-drop application of a mu-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa Biochim Biophys Acta (2012) 1822, 1783-1795. PubMed Europe PubMed DOI I
Rudel,T. To die or not to die: Shigella has an answer Cell Host Microbe (2012) 11, 219-221. PubMed Europe PubMed DOI
Santos,D.M., Xavier,J.M., Morgado,A.L., Sola,S. and Rodrigues,C.M. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation PLoS ONE (2012) 7, e33468-e33468. PubMed Europe PubMed DOI PMC EPMC
Sorimachi,H., Hata,S. and Ono,Y. Calpain-1/mu-calpain [ISSN:978-0-12-407743-0] (2012) 3, 1995-2007. DOI
Valero,J.G., Cornut-Thibaut,A., Juge,R., Debaud,A.L., Gimenez,D., Gillet,G., Bonnefoy-Berard,N., Salgado,J., Salles,G., Aouacheria,A. and Kucharczak,J. mu-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis PLoS ONE (2012) 7, e38620-e38620. PubMed Europe PubMed DOI PMC EPMC
Wang,J.C., Zhao,Y., Li,X.D., Zhou,N.N., Sun,H. and Sun,Y.Y. Proteolysis by endogenous calpain I leads to the activation of calcineurin in human heart Clin Lab (2012) 58, 1145-1152. PubMed Europe PubMed DOI
Wei,G., Yin,Y., Li,W., Bito,H., She,H. and Mao,Z. Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors J Biol Chem (2012) 287, 5797-5805. PubMed Europe PubMed DOI
Wieschhaus,A., Khan,A., Zaidi,A., Rogalin,H., Hanada,T., Liu,F., De Franceschi,L., Brugnara,C., Rivera,A. and Chishti,A.H. Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology Biochem J (2012) 448, 141-152. PubMed Europe PubMed DOI K
Yamada,K.H., Kozlowski,D.A., Seidl,S.E., Lance,S., Wieschhaus,A.J., Sundivakkam,P., Tiruppathi,C., Chishti,I., Herman,I.M., Kuchay,S.M. and Chishti,A.H. Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress J Biol Chem (2012) 287, 13182-13193. PubMed Europe PubMed DOI K
Yamashita,T., Hideyama,T., Hachiga,K., Teramoto,S., Takano,J., Iwata,N., Saido,T.C. and Kwak,S. A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology Nat Commun (2012) 3, 1307-1307. PubMed Europe PubMed DOI
Yokoyama,S., Arakawa,R., Wu,C.A., Iwamoto,N., Lu,R., Tsujita,M. and Abe-Dohmae,S. Calpain-mediated ABCA1 degradation: post-translational regulation of ABCA1 for HDL biogenesis Biochim Biophys Acta (2012) 1821, 547-551. PubMed Europe PubMed DOI
Zhao,Y., Malinin,N.L., Meller,J., Ma,Y., West,X.Z., Bledzka,K., Qin,J., Podrez,E.A. and Byzova,T.V. Regulation of cell adhesion and migration by kindlin-3 cleavage by calpain J Biol Chem (2012) 287, 40012-40020. PubMed Europe PubMed DOI P
Zhou,H.Y., Chen,S.R., Byun,H.S., Chen,H., Li,L., Han,H.D., Lopez-Berestein,G., Sood,A.K. and Pan,H.L. N-Methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain J Biol Chem (2012) 287, 33853-33864. PubMed Europe PubMed DOI T

2011

Chen,Q., Paillard,M., Gomez,L., Ross,T., Hu,Y., Xu,A. and Lesnefsky,E.J. Activation of mitochondrial mu-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion Biochem Biophys Res Commun (2011) 415, 533-538. PubMed Europe PubMed DOI I
Donkor,I.O. Calpain inhibitors: a survey of compounds reported in the patent and scientific literature Expert Opin Ther Pat (2011) 21, 601-636. PubMed Europe PubMed DOI I
Feng,Z.H., Hao,J., Ye,L., Dayao,C., Yan,N., Yan,Y., Chu,L. and Shi,F.D. Overexpression of mu-calpain in the anterior temporal neocortex of patients with intractable epilepsy correlates with clinicopathological characteristics Seizure (2011) 20, 395-401. PubMed Europe PubMed DOI
Hsu,C.Y., Henry,J., Raymond,A.A., Mechin,M.C., Pendaries,V., Nassar,D., Hansmann,B., Balica,S., Burlet-Schiltz,O., Schmitt,A.M., Takahara,H., Paul,C., Serre,G. and Simon,M. Deimination of human filaggrin-2 promotes its proteolysis by calpain 1 J Biol Chem (2011) 286, 23222-23233. PubMed Europe PubMed DOI
Iglesias,P.P., Caffaro,M.E., Amadio,A.F., Arias Manotti,A. and Poli,M.A. CAPN1 markers in three Argentinean cattle breeds: report of a new InDel polymorphism within intron 17 Mol Biol Rep (2011) 38, 1645-1649. PubMed Europe PubMed DOI
Kopil,C.M., Vais,H., Cheung,K.H., Siebert,A.P., Mak,D.O., Foskett,J.K. and Neumar,R.W. Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis J Biol Chem (2011) 286, 35998-36010. PubMed Europe PubMed DOI
Lai,Y., Riley,K., Cai,A., Leong,J.M. and Herman,I.M. Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli Front Microbiol (2011) 2, 222-222. PubMed Europe PubMed DOI
Lee,E., Jang,I., Shin,M.J., Cho,H.J., Kim,J., Eom,J.E., Kwon,Y. and Na,Y. Chalcones as novel non-peptidic mu-calpain inhibitors Bull Korean Chem Soc (2011) 32, 3459-3464. DOI I
Liu,M.C., Kobeissy,F., Zheng,W., Zhang,Z., Hayes,R.L. and Wang,K.K. Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions ASN Neuro (2011) 3, e00051-e00051. PubMed Europe PubMed DOI PMC EPMC P I
Liu,Z., Cao,J., Gao,X., Ma,Q., Ren,J. and Xue,Y. GPS-CCD: a novel computational program for the prediction of calpain cleavage sites PLoS ONE (2011) 6, e19001-e19001. PubMed Europe PubMed DOI PMC EPMC
Mohrhauser,D.A., Underwood,K.R. and Weaver,A.D. In vitro degradation of bovine myofibrils is caused by mu-calpain, not caspase-3 J Anim Sci (2011) 89, 798-808. PubMed Europe PubMed DOI
Panigrahi,A.K., Zhang,N., Mao,Q. and Pati,D. Calpain-1 cleaves Rad21 to promote sister chromatid separation Mol Cell Biol (2011) 31, 4335-4347. PubMed Europe PubMed DOI
Stuart,B.G., Coxon,J.M., Morton,J.D., Abell,A.D., McDonald,D.Q., Aitken,S.G., Jones,M.A. and Bickerstaffe,R. Molecular modeling: a search for a calpain inhibitor as a new treatment for cataractogenesis J Med Chem (2011) 54, 7503-7522. PubMed Europe PubMed DOI I
Taneike,M., Mizote,I., Morita,T., Watanabe,T., Hikoso,S., Yamaguchi,O., Takeda,T., Oka,T., Tamai,T., Oyabu,J., Murakawa,T., Nakayama,H., Nishida,K., Takeda,J., Mochizuki,N., Komuro,I. and Otsu,K. Calpain protects the heart from hemodynamic stress J Biol Chem (2011) 286, 32170-32177. PubMed Europe PubMed DOI K
Yoo,Y.J., Nam,D.H., Jung,S.Y., Jang,J.W., Kim,H.J., Jin,C., Pae,A.N. and Lee,Y.S. Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors Bioorg Med Chem Lett (2011) 21, 2850-2854. PubMed Europe PubMed DOI I

2010

Bastian,Y., Roa-Espitia,A.L., Mujica,A. and Hernandez-Gonzalez,E.O. Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton Reproduction (2010) 140, 673-684. PubMed Europe PubMed DOI
Bevers,M.B., Ingleton,L.P., Che,D., Cole,J.T., Li,L., Da,T., Kopil,C.M., Cohen,A.S. and Neumar,R.W. RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia Exp Neurol (2010) 224, 170-177. PubMed Europe PubMed DOI K
Esteves,A.R., Arduino,D.M., Swerdlow,R.H., Oliveira,C.R. and Cardoso,S.M. Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology Neurobiol Dis (2010) 37, 723-730. PubMed Europe PubMed DOI
Farr,C. and Berger,S. Measuring calpain activity in fixed and living cells by flow cytometry J Vis Exp (2010) , 2050-2050. PubMed Europe PubMed DOI A
Kar,P., Samanta,K., Shaikh,S., Chowdhury,A., Chakraborti,T. and Chakraborti,S. Mitochondrial calpain system: an overview Arch Biochem Biophys (2010) 495, 1-7. PubMed Europe PubMed DOI
Kim,K.A., Lee,Y.A. and Shin,M.H. Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica Parasite Immunol (2010) 32, 176-183. PubMed Europe PubMed DOI I
Kulkarni,S., Reddy,K.B., Esteva,F.J., Moore,H.C., Budd,G.T. and Tubbs,R.R. Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer Oncogene (2010) 29, 1339-1350. PubMed Europe PubMed DOI
Murphy,R.M. Calpains, skeletal muscle function and exercise Clin Exp Pharmacol Physiol (2010) 37, 385-391. PubMed Europe PubMed DOI
Ovat,A., Li,Z.Z., Hampton,C.Y., Asress,S.A., Fernandez,F.M., Glass,J.D. and Powers,J.C. Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors J Med Chem (2010) 53, 6326-6336. PubMed Europe PubMed DOI I
Sahara,S. and Yamashima,T. Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death Biochem Biophys Res Commun (2010) 393, 806-811. PubMed Europe PubMed DOI
Wells,A. and Leloup,L. Calpain Handb of Cell Signaling, 2/e (2010) 2, 999-1008. DOI V
Zhang,P., Sridharan,D. and Lambert,M.W. Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair Biochemistry (2010) 49, 5570-5581. PubMed Europe PubMed DOI K

2009

Averna,M., Stifanese,R., De Tullio,R., Beccaria,F., Salamino,F., Pontremoli,S. and Melloni,E. Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells J Neurochem (2009) 110, 412-421. PubMed Europe PubMed DOI
Aviles,C., Azor,P.J., Pannier,L., Hamill,R.M., Membrillo,A. and Molina,A. New single nucleotide polymorphisms in the mu-calpain gene in Spanish maternal beef breeds Anim Biotechnol (2009) 20, 161-164. PubMed Europe PubMed DOI M
Baliova,M., Knab,A., Franekova,V. and Jursky,F. Modification of the cytosolic regions of GABA transporter GAT1 by calpain Neurochem Int (2009) 55, 288-294. PubMed Europe PubMed DOI
Camins,A., Crespo-Biel,N., Junyent,F., Verdaguer,E., Canudas,A.M. and Pallas,M. Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium Curr Drug Metab (2009) 10, 433-447. PubMed Europe PubMed DOI V
Doshi,S. and Lynch,D.R. Calpain and the glutamatergic synapse Front Biosci (Schol Ed) (2009) 1, 466-476. PubMed Europe PubMed V
Gafni,J., Cong,X., Chen,S.F., Gibson,B.W. and Ellerby,L.M. Calpain-1 cleaves and activates caspase-7 J Biol Chem (2009) 284, 25441-25449. PubMed Europe PubMed DOI PMC EPMC
Gerencser,A.A., Mark,K.A., Hubbard,A.E., Divakaruni,A.S., Mehrabian,Z., Nicholls,D.G. and Polster,B.M. Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity J Neurochem (2009) 110, 990-1004. PubMed Europe PubMed DOI PMC EPMC
Guyton,M.K., Brahmachari,S., Das,A., Samantaray,S., Inoue,J., Azuma,M., Ray,S.K. and Banik,N.L. Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells J Neurochem (2009) 110, 1895-1907. PubMed Europe PubMed DOI PMC EPMC I
Hayakawa,M., Hayakawa,H., Matsuyama,Y., Tamemoto,H., Okazaki,H. and Tominaga,S. Mature interleukin-33 is produced by calpain-mediated cleavage in vivo Biochem Biophys Res Commun (2009) 387, 218-222. PubMed Europe PubMed DOI
Joshi,A., Bondada,V. and Geddes,J.W. Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor Exp Neurol (2009) 218, 221-227. PubMed Europe PubMed DOI PMC EPMC
Kang,D.H., Jun,K.Y., Lee,J.P., Pak,C.S., Na,Y. and Kwon,Y. Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity J Med Chem (2009) 52, 3093-3097. PubMed Europe PubMed DOI I
Kelly,J.C., Cuerrier,D., Graham,L.A., Campbell,R.L. and Davies,P.L. Profiling of calpain activity with a series of FRET-based substrates Biochim Biophys Acta (2009) 1794, 1505-1509. PubMed Europe PubMed DOI A P
Lee,K.Y., Lee,K.S., Jin,C. and Lee,Y.S. Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives Eur J Med Chem (2009) 44, 1331-1334. PubMed Europe PubMed DOI I
Li,Y., Li,Y., Feng,Q., Arnold,M. and Peng,T. Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes Cardiovasc Res (2009) 84, 100-110. PubMed Europe PubMed DOI
Lisa,C. and Di Stasio,L. Variability of mu-calpain and calpastatin genes in cattle Ital J Anim Sci (2009) 8, 99-101.
McClung,J.M., Judge,A.R., Talbert,E.E. and Powers,S.K. Calpain-1 is required for hydrogen peroxide-induced myotube atrophy Am J Physiol Cell Physiol (2009) 296, C363-C371. PubMed Europe PubMed DOI PMC EPMC
Mellgren,R.L., Miyake,K., Kramerova,I., Spencer,M.J., Bourg,N., Bartoli,M., Richard,I., Greer,P.A. and McNeil,P.L. Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases Biochim Biophys Acta (2009) 1793, 1886-1893. PubMed Europe PubMed DOI
Passiatore,G., Rom,S., Eletto,D. and Peruzzi,F. HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity Biochim Biophys Acta (2009) 1793, 378-387. PubMed Europe PubMed DOI PMC EPMC I
Ravulapalli,R., Campbell,R.L., Gauthier,S.Y., Dhe-Paganon,S. and Davies,P.L. Distinguishing between calpain heterodimerization and homodimerization FEBS J (2009) 276, 973-982. PubMed Europe PubMed DOI
Vaisid,T., Barnoy,S. and Kosower,N.S. Calpain activates caspase-8 in neuron-like differentiated PC12 cells via the amyloid-beta-peptide and CD95 pathways Int J Biochem Cell Biol (2009) 41, 2450-2458. PubMed Europe PubMed DOI
Zhang,Y., Jung,S.Y., Jin,C., Kim,N.D., Gong,P. and Lee,Y.S. Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors Bioorg Med Chem Lett (2009) 19, 502-507. PubMed Europe PubMed DOI I

2008

Azuma,M. and Shearer,T.R. The role of calcium-activated protease calpain in experimental retinal pathology Surv Ophthalmol (2008) 53, 150-163. PubMed Europe PubMed DOI PMC EPMC I
Badugu,R., Garcia,M., Bondada,V., Joshi,A. and Geddes,J.W. N Terminus of calpain 1 is a mitochondrial targeting sequence J Biol Chem (2008) 283, 3409-3417. PubMed Europe PubMed DOI
Cheong,H.S., Yoon,D.H., Park,B.L., Kim,L.H., Bae,J.S., Namgoong,S., Lee,H.W., Han,C.S., Kim,J.O., Cheong,I.C. and Shin,H.D. A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle BMC Genet (2008) 9, 33-33. PubMed Europe PubMed DOI PMC EPMC
Dargelos,E., Poussard,S., Brule,C., Daury,L. and Cottin,P. Calcium-dependent proteolytic system and muscle dysfunctions: a possible role of calpains in sarcopenia Biochimie (2008) 90, 359-368. PubMed Europe PubMed DOI
Donkor,I.O., Assefa,H. and Liu,J. Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids J Med Chem (2008) 51, 4346-4350. PubMed Europe PubMed DOI PMC EPMC I
Donkor,I.O. and Korukonda,R. Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position Bioorg Med Chem Lett (2008) 18, 4806-4808. PubMed Europe PubMed DOI PMC EPMC I
Jones,M.A., Morton,J.D., Coxon,J.M., McNabb,S.B., Lee,H.Y., Aitken,S.G., Mehrtens,J.M., Robertson,L.J., Neffe,A.T., Miyamoto,S., Bickerstaffe,R., Gately,K., Wood,J.M. and Abell,A.D. Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors Bioorg Med Chem (2008) 16, 6911-6923. PubMed Europe PubMed DOI I
Koumura,A., Nonaka,Y., Hyakkoku,K., Oka,T., Shimazawa,M., Hozumi,I., Inuzuka,T. and Hara,H. A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl )-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice Neuroscience (2008) 157, 309-318. PubMed Europe PubMed DOI I
Kuznetsov,S. and Khokhlatchev,A.V. The growth and tumor suppressors NORE1A and RASSF1A are targets for calpain-mediated proteolysis PLoS ONE (2008) 3, e3997-e3997. PubMed Europe PubMed DOI PMC EPMC
Liu,J., Liu,M.C. and Wang,K.K. Calpain in the CNS: from synaptic function to neurotoxicity Sci Signal (2008) 1, re1-re1. PubMed Europe PubMed DOI V
Pfizer,J., Assfalg-Machleidt,I., Machleidt,W. and Schaschke,N. Inhibition of human mu-calpain by conformationally constrained calpastatin peptides Biol Chem (2008) 389, 83-90. PubMed Europe PubMed DOI
Qian,J., Cuerrier,D., Davies,P.L., Li,Z., Powers,J.C. and Campbell,R.L. Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions J Med Chem (2008) 51, 5264-5270. PubMed Europe PubMed DOI PMC EPMC S I
Sha,D., Jin,Y., Wu,H., Wei,J., Lin,C.H., Lee,Y.H., Buddhala,C., Kuchay,S., Chishti,A.H. and Wu,J.Y. Role of mu-calpain in proteolytic cleavage of brain l-glutamic acid decarboxylase Brain Res (2008) 1207, 9-18. PubMed Europe PubMed DOI PMC EPMC P
Sprague,C.R., Fraley,T.S., Jang,H.S., Lal,S. and Greenwood,J.A. Phosphoinositide binding to the substrate regulates susceptibility to proteolysis by calpain J Biol Chem (2008) 283, 9217-9223. PubMed Europe PubMed DOI PMC EPMC P
Upla,P., Marjomaki,V., Nissinen,L., Nylund,C., Waris,M., Hyypia,T. and Heino,J. Calpain 1 and 2 are required for RNA replication of echovirus 1 J Virol (2008) 82, 1581-1590. PubMed Europe PubMed DOI PMC EPMC

2007

Bolshakov,V.Y. SCOPing out proteases in long-term memory Cell (2007) 128, 1029-1030. PubMed Europe PubMed DOI
Cao,G., Xing,J., Xiao,X., Liou,A.K., Gao,Y., Yin,X.M., Clark,R.S., Graham,S.H. and Chen,J. Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury J Neurosci (2007) 27, 9278-9293. PubMed Europe PubMed DOI
Cuerrier,D., Moldoveanu,T., Campbell,R.L., Kelly,J., Yoruk,B., Verhelst,S.H., Greenbaum,D., Bogyo,M. and Davies,P.L. Development of calpain-specific inactivators by screening of positional scanning epoxide libraries J Biol Chem (2007) 282, 9600-9611. PubMed Europe PubMed DOI I
Davis,T.L., Walker,J.R., Finerty,P.J., Jr., Mackenzie,F., Newman,E.M. and Dhe-Paganon,S. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition J Mol Biol (2007) 366, 216-229. PubMed Europe PubMed DOI S
Dufty,B.M., Warner,L.R., Hou,S.T., Jiang,S.X., Gomez-Isla,T., Leenhouts,K.M., Oxford,J.T., Feany,M.B., Masliah,E. and Rohn,T.T. Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation Am J Pathol (2007) 170, 1725-1738. PubMed Europe PubMed DOI PMC EPMC
Goni-Oliver,P., Lucas,J.J., Avila,J. and Hernandez,F. N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation J Biol Chem (2007) 282, 22406-22413. PubMed Europe PubMed DOI
Haacke,A., Hartl,F.U. and Breuer,P. Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3 J Biol Chem (2007) 282, 18851-18856. PubMed Europe PubMed DOI
Harper,A.G. and Sage,S.O. A role for the intracellular protease calpain in the activation of store-operated calcium entry in human platelets Cell Calcium (2007) 41, 169-178. PubMed Europe PubMed DOI
Kuchay,S.M., Kim,N., Grunz,E.A., Fay,W.P. and Chishti,A.H. Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets Mol Cell Biol (2007) 27, 6038-6052. PubMed Europe PubMed DOI PMC EPMC K
Mellgren,R.L., Zhang,W., Miyake,K. and McNeil,P.L. Calpain is required for the rapid, calcium-dependent repair of wounded plasma membrane J Biol Chem (2007) 282, 2567-2575. PubMed Europe PubMed DOI
Saito,M., Li,H., Thompson,V.F., Kunisaki,N. and Goll,D.E. Purification and characterization of calpain and calpastatin from rainbow trout, Oncorhynchus mykiss Comp Biochem Physiol B Biochem Mol Biol (2007) 146, 445-455. PubMed Europe PubMed DOI
Shimizu,K., Phan,T., Mansuy,I.M. and Storm,D.R. Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory Cell (2007) 128, 1219-1229. PubMed Europe PubMed DOI PMC EPMC
Struewing,I.T., Barnett,C.D., Zhang,W., Yadav,S. and Mao,C.D. Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+)-dependent protease calpain-1 Exp Cell Res (2007) 313, 3526-3541. PubMed Europe PubMed DOI
Wu,Y., Liang,S., Oda,Y., Ohmori,I., Nishiki,T., Takei,K., Matsui,H. and Tomizawa,K. Truncations of amphiphysin I by calpain inhibit vesicle endocytosis during neural hyperexcitation EMBO J (2007) 26, 2981-2990. PubMed Europe PubMed DOI PMC EPMC
Yaroslavskiy,B.B., Sharrow,A.C., Wells,A., Robinson,L.J. and Blair,H.C. Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility J Cell Sci (2007) 120, 2884-2894. PubMed Europe PubMed DOI
Yu,C.G. and Geddes,J.W. Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury Neurochem Res (2007) 32, 2046-2053. PubMed Europe PubMed DOI I

2006

Casas,E., White,S.N., Wheeler,T.L., Shackelford,S.D., Koohmaraie,M., Riley,D.G., Chase,C.C., Jr., Johnson,D.D. and Smith,T.P. Effects of calpastatin and micro-calpain markers in beef cattle on tenderness traits J Anim Sci (2006) 84, 520-525. PubMed Europe PubMed
Chicharro,R., Alonso,M., Mazo,M.T., Aran,V.J. and Herradon,B. Derivatives of 3-sec-butyl-1-oxo-2,3-dihydroisoquinoline as inhibitors of mu-calpain ChemMedChem (2006) 1, 710-714. PubMed Europe PubMed DOI I
[YEAR:20-6-2006]Cuerrier,D., Moldoveanu,T., Inoue,J., Davies,P.L. and Campbell,R.L. Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography Biochemistry (20-6-2006) 45, 7446-7452. PubMed Europe PubMed DOI S I
Geesink,G.H., Kuchay,S., Chishti,A.H. and Koohmaraie,M. Micro-calpain is essential for postmortem proteolysis of muscle proteins J Anim Sci (2006) 84, 2834-2840. PubMed Europe PubMed DOI K
Guan,N., Korukonda,R., Hurh,E., Schmittgen,T.D., Donkor,I.O. and Dalton,J.T. Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines Int J Oncol (2006) 29, 655-663. PubMed Europe PubMed I
Koohmaraie,M. and Geesink,G.H. Contribution of postmortem muscle biochemistry to the delivery of consistent meat quality with particular focus on the calpain system Meat Sci (2006) 74, 34-43. PubMed Europe PubMed DOI
[YEAR:24-8-2006]Korukonda,R., Guan,N., Dalton,J.T., Liu,J. and Donkor,I.O. Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides J Med Chem (24-8-2006) 49, 5282-5290. PubMed Europe PubMed DOI I
Lebart,M.C. and Benyamin,Y. Calpain involvement in the remodeling of cytoskeletal anchorage complexes FEBS J (2006) 273, 3415-3426. PubMed Europe PubMed DOI
[YEAR:24-1-2006]Li,Q., Hanzlik,R.P., Weaver,R.F. and Schonbrunn,E. Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core Biochemistry (24-1-2006) 45, 701-708. PubMed Europe PubMed DOI S I
[YEAR:24-3-2006]Nakatsu,Y., Kotake,Y. and Ohta,S. Tributyltin-induced cell death is mediated by calpain in PC12 cells Neurotoxicology (24-3-2006) 27, 587-593. PubMed Europe PubMed DOI I
[YEAR:27-10-2006]Raynaud,F., Fabrice,R., Jond-Necand,C., Carole,J.N., Marcilhac,A., Anne,M., Furst,D., Dieter,F., Benyamin,Y. and Yves,B. Calpain 1-gamma filamin interaction in muscle cells: a possible in situ regulation by PKC-alpha Int J Biochem Cell Biol (27-10-2006) 38, 404-413. PubMed Europe PubMed DOI
[YEAR:10-1-2006]Sanders,M.L. and Donkor,I.O. A novel series of urea-based peptidomimetic calpain inhibitors Bioorg Med Chem Lett (10-1-2006) 16, 1965-1968. PubMed Europe PubMed DOI I
[YEAR:29-6-2006]Shirasaki,Y., Nakamura,M., Yamaguchi,M., Miyashita,H., Sakai,O. and Inoue,J. Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives J Med Chem (29-6-2006) 49, 3926-3932. PubMed Europe PubMed DOI I
[YEAR:29-4-2006]Shirasaki,Y., Miyashita,H. and Yamaguchi,M. Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl alpha-ketoamide derivatives containing pyridine moiety Bioorg Med Chem (29-4-2006) 14, 5691-5698. PubMed Europe PubMed DOI I
Shirasaki,Y., Yamaguchi,M. and Miyashita,H. Retinal penetration of calpain inhibitors in rats after oral administration J Ocul Pharmacol Ther (2006) 22, 417-424. PubMed Europe PubMed DOI I
Weyermann,P., Herzner,H., Lescop,C., Siendt,H., Bolliger,R., Hennebohle,M., Rummey,C. and Meier,T. Synthesis and evaluation of calpain inhibitors carrying muscle cell targeting groups Lett Drug Des Discov (2006) 3, 152-158. I
Wu,H.Y. and Lynch,D.R. Calpain and synaptic function Mol Neurobiol (2006) 33, 215-236. PubMed Europe PubMed DOI V
[YEAR:26-9-2006]Zhang,Z., Biesiadecki,B.J. and Jin,J.P. Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage Biochemistry (26-9-2006) 45, 11681-11694. PubMed Europe PubMed DOI

2005

Arataki,S., Tomizawa,K., Moriwaki,A., Nishida,K., Matsushita,M., Ozaki,T., Kunisada,T., Yoshida,A., Inoue,H. and Matsui,H. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats J Neurotrauma (2005) 22, 398-406. PubMed Europe PubMed DOI I
[YEAR:13-5-2005]Chen,M. and Fernandez,H.L. mu-Calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein Biochem Biophys Res Commun (13-5-2005) 330, 714-721. PubMed Europe PubMed DOI U
[YEAR:10-10-2005]Cuerrier,D., Moldoveanu,T. and Davies,P.L. Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions J Biol Chem (10-10-2005) 280, 40632-40641. PubMed Europe PubMed DOI P
[YEAR:20-6-2005]Das,A., Sribnick,E.A., Wingrave,J.M., Del Re,A.M., Woodward,J.J., Appel,S.H., Banik,N.L. and Ray,S.K. Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection J Neurosci Res (20-6-2005) 81, 551-562. PubMed Europe PubMed DOI I
[YEAR:24-10-2005]Garcia,M., Bondada,V. and Geddes,J.W. Mitochondrial localization of mu-calpain Biochem Biophys Res Commun (24-10-2005) 338, 1241-1247. PubMed Europe PubMed DOI
[YEAR:5-9-2005]Grammer,M., Kuchay,S., Chishti,A. and Baudry,M. Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice Neurobiol Learn Mem (5-9-2005) 84, 222-227. PubMed Europe PubMed DOI K
Hayashi,M., Koshihara,Y., Ishibashi,H., Yamamoto,S., Tsubuki,S., Saido,T.C., Kawashima,S. and Inomata,M. Involvement of calpain in osteoclastic bone resorption J Biochem (2005) 137, 331-338. PubMed Europe PubMed DOI
Higuchi,M., Tomioka,M., Takano,J., Shirotani,K., Iwata,N., Masumoto,H., Maki,M., Itohara,S. and Saido,T.C. Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors J Biol Chem (2005) 280, 15229-15237. PubMed Europe PubMed DOI
[YEAR:2-6-2005]Lee,K.S., Seo,S.H., Lee,Y.H., Kim,H.D., Son,M.H., Chung,B.Y., Lee,J.Y., Jin,C. and Lee,Y.S. Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors Bioorg Med Chem Lett (2-6-2005) 15, 2857-2860. PubMed Europe PubMed DOI I
Liu,F., Grundke-Iqbal,I., Iqbal,K., Oda,Y., Tomizawa,K. and Gong,C.X. Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain J Biol Chem (2005) 280, 37755-37762. PubMed Europe PubMed DOI
[YEAR:31-5-2005]Mishizen-Eberz,A.J., Norris,E.H., Giasson,B.I., Hodara,R., Ischiropoulos,H., Lee,V.M., Trojanowski,J.Q. and Lynch,D.R. Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein Biochemistry (31-5-2005) 44, 7818-7829. PubMed Europe PubMed DOI
[YEAR:22-3-2005]Parnaud,G., Hammar,E., Rouiller,D.G. and Bosco,D. Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion Am J Physiol Endocrinol Metab (22-3-2005) 289, E313-E321. PubMed Europe PubMed DOI I
[YEAR:7-12-2005]Polster,B.M., Basanez,G., Etxebarria,A., Hardwick,J.M. and Nicholls,D.G. Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria J Biol Chem (7-12-2005) 280, 6447-6454. PubMed Europe PubMed DOI I
Raynaud,F., Fernandez,E., Coulis,G., Aubry,L., Vignon,X., Bleimling,N., Gautel,M., Benyamin,Y. and Ouali,A. Calpain 1-titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril FEBS J (2005) 272, 2578-2590. PubMed Europe PubMed DOI
Salem,M., Nath,J., Rexroad,C.E., Killefer,J. and Yao,J. Identification and molecular characterization of the rainbow trout calpains (Capn1 and Capn2): their expression in muscle wasting during starvation Comp Biochem Physiol B Biochem Mol Biol (2005) 140, 63-71. PubMed Europe PubMed DOI
[YEAR:24-5-2005]Shirasaki,Y., Miyashita,H., Yamaguchi,M., Inoue,J. and Nakamura,M. Exploration of orally available calpain inhibitors: peptidyl alpha-ketoamides containing an amphiphile at P3 site Bioorg Med Chem (24-5-2005) 13, 4473-4484. PubMed Europe PubMed DOI I
Takano,J., Tomioka,M., Tsubuki,S., Higuchi,M., Iwata,N., Itohara,S., Maki,M. and Saido,T.C. Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice J Biol Chem (2005) 280, 16175-16184. PubMed Europe PubMed DOI
Wells,A., Huttenlocher,A. and Lauffenburger,D.A. Calpain proteases in cell adhesion and motility Int Rev Cytol (2005) 245, 1-16. PubMed Europe PubMed DOI V

2004

[YEAR:11-11-2004]Altznauer,F., Conus,S., Cavalli,A., Folkers,G. and Simon,H.U. Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis J Biol Chem (11-11-2004) 279, 5947-5957. PubMed Europe PubMed DOI I
[YEAR:1-1-2004]Donkor,I.O., Han,J. and Zheng,X. Design, synthesis, molecular modeling studies, and calpain inhibitory activity of novel alpha-ketoamides incorporating polar residues at the P1'-position J Med Chem (1-1-2004) 47, 72-79. PubMed Europe PubMed DOI I
[YEAR:22-10-2004]Farkas,B., Tantos,A., Schlett,K., Vilagi,I. and Friedrich,P. Ischemia-induced increase in long-term potentiation is warded off by specific calpain inhibitor PD150606 Brain Res (22-10-2004) 1024, 150-158. PubMed Europe PubMed DOI I
[YEAR:4-6-2004]Fernandez-Montalvan,A., Assfalg-Machleidt,I., Pfeiler,D., Fritz,H., Jochum,M. and Machleidt,W. Electrostatic interactions of domain III stabilize the inactive conformation of mu-calpain Biochem J (4-6-2004) 382, 607-617. PubMed Europe PubMed DOI PMC EPMC
Franco,S.J., Rodgers,M.A., Perrin,B.J., Han,J., Bennin,D.A., Critchley,D.R. and Huttenlocher,A. Calpain-mediated proteolysis of talin regulates adhesion dynamics Nat Cell Biol (2004) 6, 977-983. PubMed Europe PubMed DOI
Franco,S.J., Rodgers,M.A., Perrin,B.J., Han,J.W., Bennin,D.A., Critchley,D.R. and Huttenlocher,A. Calpain-mediated proteolysis of talin regulates adhesion dynamics Nat Cell Biol (2004) 6, 1145-1147. PubMed Europe PubMed DOI
[YEAR:29-10-2004]Friedrich,P. The intriguing Ca2+ requirement of calpain activation Biochem Biophys Res Commun (29-10-2004) 323, 1131-1133. PubMed Europe PubMed DOI
Juszczuk-Kubiak,E., Sakowski,T., Flisikowski,K., Wicinska,K., Oprzadek,J. and Rosochacki,S.J. Bovine mu-calpain (CAPN1) gene: new SNP within intron 14 J Appl Genet (2004) 45, 457-460. PubMed Europe PubMed M
Kent,M.P., Spencer,M.J. and Koohmaraie,M. Postmortem proteolysis is reduced in transgenic mice overexpressing calpastatin J Anim Sci (2004) 82, 794-801. PubMed Europe PubMed
[YEAR:3-5-2004]Li,H., Thompson,V.F. and Goll,D.E. Effects of autolysis on properties of mu- and m-calpain Biochim Biophys Acta (3-5-2004) 1691, 91-103. PubMed Europe PubMed DOI
[YEAR:5-12-2004]Moldoveanu,T., Campbell,R.L., Cuerrier,D. and Davies,P.L. Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site J Mol Biol (5-12-2004) 343, 1313-1326. PubMed Europe PubMed DOI S I
Moldoveanu,T., Jia,Z. and Davies,P.L. Calpain activation by cooperative Ca2+ binding at two non-EF-hand sites J Biol Chem (2004) 279, 6106-6114. PubMed Europe PubMed DOI
Montero,A., Mann,E., Chana,A. and Herradon,B. Peptide-biphenyl hybrids as calpain inhibitors Chem Biodivers (2004) 1, 442-457. PubMed Europe PubMed DOI I
Moyen,C., Goudenege,S., Poussard,S., Sassi,A.H., Brustis,J.J. and Cottin,P. Involvement of micro-calpain (CAPN 1) in muscle cell differentiation Int J Biochem Cell Biol (2004) 36, 728-743. PubMed Europe PubMed DOI
Page,B.T., Casas,E., Quaas,R.L., Thallman,R.M., Wheeler,T.L., Shackelford,S.D., Koohmaraie,M., White,S.N., Bennett,G.L., Keele,J.W., Dikeman,M.E. and Smith,T.P. Association of markers in the bovine CAPN1 gene with meat tenderness in large crossbred populations that sample influential industry sires J Anim Sci (2004) 82, 3474-3481. PubMed Europe PubMed
Sorimachi,H. mu-Calpain [ISSN:0-12-079610-4] (2004) 2, 1206-1211. V
Wang,M.S., Davis,A.A., Culver,D.G., Wang,Q., Powers,J.C. and Glass,J.D. Calpain inhibition protects against Taxol-induced sensory neuropathy Brain (2004) 127, 671-679. PubMed Europe PubMed DOI I
[YEAR:19-11-2004]Wu,H.Y., Tomizawa,K., Oda,Y., Wei,F.Y., Lu,Y.F., Matsushita,M., Li,S.T., Moriwaki,A. and Matsui,H. Critical role of calpain-mediated cleavage of calcineurinin excitotoxic neurodegeneration J Biol Chem (19-11-2004) 279, 4929-4940. PubMed Europe PubMed DOI I
[YEAR:16-3-2004]Yadavalli,R., Guttmann,R.P., Seward,T., Centers,A.P., Williamson,R.A. and Telling,G.C. Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation J Biol Chem (16-3-2004) 279, 21948-21956. PubMed Europe PubMed DOI
[YEAR:23-8-2004]Zalewska,T., Thompson,V.F. and Goll,D.E. Effect of phosphatidylinositol and inside-out erythrocyte vesicles on autolysis of mu- and m-calpain from bovine skeletal muscle Biochim Biophys Acta (23-8-2004) 1693, 125-133. PubMed Europe PubMed DOI

2003

Buki,A., Farkas,O., Doczi,T. and Povlishock,J.T. Preinjury administration of the calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury J Neurotrauma (2003) 20, 261-268. PubMed Europe PubMed DOI I
[YEAR:1-7-2003]Cuevas,B.D., Abell,A.N., Witowsky,J.A., Yujiri,T., Johnson,N.L., Kesavan,K., Ware,M., Jones,P.L., Weed,S.A., DeBiasi,R.L., Oka,Y., Tyler,K.L. and Johnson,G.L. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts EMBO J (1-7-2003) 22, 3346-3355. PubMed Europe PubMed DOI PMC EPMC
[YEAR:10-3-2003]Donkor,I.O., Korukonda,R., Huang,T.L. and LeCour,L., Jr. Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics Bioorg Med Chem Lett (10-3-2003) 13, 783-784. PubMed Europe PubMed DOI I
Goll,D.E., Thompson,V.F., Li,H., Wei,W. and Cong,J. The calpain system Physiol Rev (2003) 83, 731-801. PubMed Europe PubMed DOI
[YEAR:5-6-2003]Lubisch,W., Beckenbach,E., Bopp,S., Hofmann,H.P., Kartal,A., Kastel,C., Lindner,T., Metz-Garrecht,M., Reeb,J., Regner,F., Vierling,M. and Moller,A. Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability J Med Chem (5-6-2003) 46, 2404-2412. PubMed Europe PubMed DOI I
[YEAR:15-8-2003]Mittoo,S., Sundstrom,L.E. and Bradley,M. Synthesis and evaluation of fluorescent probes for the detection of calpain activity Anal Biochem (15-8-2003) 319, 234-238. PubMed Europe PubMed DOI A
[YEAR:1-12-2003]Nakamura,M., Miyashita,H., Yamaguchi,M., Shirasaki,Y., Nakamura,Y. and Inoue,J. Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors Bioorg Med Chem (1-12-2003) 11, 5449-5460. PubMed Europe PubMed DOI I
Neuhof,C., Gotte,O., Trumbeckaite,S., Attenberger,M., Kuzkaya,N., Gellerich,F., Moller,A., Lubisch,W., Speth,M., Tillmanns,H. and Neuhof,H. A novel water-soluble and cell-permeable calpain inhibitor protects myocardial and mitochondrial function in postischemic reperfusion Biol Chem (2003) 384, 1597-1603. PubMed Europe PubMed DOI I
O'Hanlon,G.M., Humphreys,P.D., Goldman,R.S., Halstead,S.K., Bullens,R.W., Plomp,J.J., Ushkaryov,Y. and Willison,H.J. Calpain inhibitors protect against axonal degeneration in a model of anti-ganglioside antibody-mediated motor nerve terminal injury Brain (2003) 126, 2497-2509. PubMed Europe PubMed DOI I
Pal,G.P., De Veyra,T., Elce,J.S. and Jia,Z. Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement Structure (2003) 11, 1521-1526. PubMed Europe PubMed DOI S
[YEAR:1-11-2003]Pattni,K., Millard,T.H. and Banting,G. Calpain cleavage of the B isoform of Ins(1,4,5)P3 3-kinase separates the catalytic domain from the membrane anchoring domain Biochem J (1-11-2003) 375, 643-651. PubMed Europe PubMed DOI PMC EPMC
Ray,S.K., Hogan,E.L. and Banik,N.L. Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors Brain Res Brain Res Rev (2003) 42, 169-185. PubMed Europe PubMed DOI I
Raynaud,F., Bonnal,C., Fernandez,E., Bremaud,L., Cerutti,M., Lebart,M.C., Roustan,C., Ouali,A. and Benyamin,Y. The calpain 1-alpha-actinin interaction. Resting complex between the calcium-dependent protease and its target in cytoskeleton Eur J Biochem (2003) 270, 4662-4670. PubMed Europe PubMed DOI
[YEAR:30-5-2003]Thompson,V.F., Lawson,K.R., Barlow,J. and Goll,D.E. Digestion of mu- and m-calpain by trypsin and chymotrypsin Biochim Biophys Acta (30-5-2003) 1648, 140-153. PubMed Europe PubMed DOI
[YEAR:28-1-2003]Toyota,H., Yanase,N., Yoshimoto,T., Moriyama,M., Sudo,T. and Mizuguchi,J. Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax Cancer Lett (28-1-2003) 189, 221-230. PubMed Europe PubMed DOI
[YEAR:1-3-2003]Trumbeckaite,S., Neuhof,C., Zierz,S. and Gellerich,F.N. Calpain inhibitor (BSF 409425) diminishes ischemia/reperfusion-induced damage of rabbit heart mitochondria Biochem Pharmacol (1-3-2003) 65, 911-916. PubMed Europe PubMed DOI I
[YEAR:14-4-2003]Zhang,J., Miyamoto,K., Hashioka,S., Hao,H.P., Murao,K., Saido,T.C. and Nakanishi,H. Activation of mu-calpain in developing cortical neurons following methylmercury treatment Brain Res Dev Brain Res (14-4-2003) 142, 105-110. PubMed Europe PubMed DOI

2002

Carragher,N.O. and Frame,M.C. Calpain: a role in cell transformation and migration Int J Biochem Cell Biol (2002) 34, 1539-1543. PubMed Europe PubMed DOI
[YEAR:1-10-2002]Dutt,P., Spriggs,C.N., Davies,P.L., Jia,Z. and Elce,J.S. Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain Biochem J (1-10-2002) 367, 263-269. PubMed Europe PubMed DOI PMC EPMC
[YEAR:5-7-2002]Kulkarni,S., Goll,D.E. and Fox,J.E. Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreading J Biol Chem (5-7-2002) 277, 24435-24441. PubMed Europe PubMed DOI
[YEAR:20-5-2002]Lubisch,W. and Moller,A. Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors Bioorg Med Chem Lett (20-5-2002) 12, 1335-1338. PubMed Europe PubMed DOI I
[YEAR:20-9-2002]Manya,H., Inomata,M., Fujimori,T., Dohmae,N., Sato,Y., Takio,K., Nabeshima,Y. and Endo,T. Klotho protein deficiency leads to overactivation of mu-calpain J Biol Chem (20-9-2002) 277, 35503-35508. PubMed Europe PubMed DOI
McCollum,A.T., Nasr,P. and Estus,S. Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death J Neurochem (2002) 82, 1208-1220. PubMed Europe PubMed DOI I
Mkwetshana,N., Naude,R.J. and Muramoto,K. The purification and characterization of mu-calpain and calpastatin from ostrich brain Int J Biochem Cell Biol (2002) 34, 613-624. PubMed Europe PubMed DOI
[YEAR:8-3-2002]Moldoveanu,T., Hosfield,C.M., Lim,D., Elce,J.S., Jia,Z. and Davies,P.L. A Ca(2+) switch aligns the active site of calpain Cell (8-3-2002) 108, 649-660. PubMed Europe PubMed DOI S
Page,B.T., Casas,E., Heaton,M.P., Cullen,N.G., Hyndman,D.L., Morris,C.A., Crawford,A.M., Wheeler,T.L., Koohmaraie,M., Keele,J.W. and Smith,T.P. Evaluation of single-nucleotide polymorphisms in CAPN1 for association with meat tenderness in cattle J Anim Sci (2002) 80, 3077-3085. PubMed Europe PubMed M
[YEAR:4-10-2002]Rutledge,T.W. and Whiteheart,S.W. SNAP-23 is a target for calpain cleavage in activated platelets J Biol Chem (4-10-2002) 277, 37009-37015. PubMed Europe PubMed DOI I
[YEAR:15-4-2002]Small,G.W., Chou,T.Y., Dang,C.V. and Orlowski,R.Z. Evidence for involvement of calpain in c-Myc proteolysis in vivo Arch Biochem Biophys (15-4-2002) 400, 151-161. PubMed Europe PubMed DOI I

2001

Azam,M., Andrabi,S.S., Sahr,K.E., Kamath,L., Kuliopulos,A. and Chishti,A.H. Disruption of the mouse mu-calpain gene reveals an essential role in platelet function Mol Cell Biol (2001) 21, 2213-2220. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:17-8-2001]Chen,M., He,H., Zhan,S., Krajewski,S., Reed,J.C. and Gottlieb,R.A. Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion J Biol Chem (17-8-2001) 276, 30724-30728. PubMed Europe PubMed DOI
Cottin,P., Thompson,V.F., Sathe,S.K., Szpacenko,A. and Goll,D.E. Autolysis of mu- and m-calpain from bovine skeletal muscle Biol Chem (2001) 382, 767-776. PubMed Europe PubMed DOI
DeBiasi,R.L., Edelstein,C.L., Sherry,B. and Tyler,K.L. Calpain inhibition protects against virus-induced apoptotic myocardial injury J Virol (2001) 75, 351-361. PubMed Europe PubMed DOI PMC EPMC I
Delgado,E.F., Geesink,G.H., Marchello,J.A., Goll,D.E. and Koohmaraie,M. Properties of myofibril-bound calpain activity in longissimus muscle of callipyge and normal sheep J Anim Sci (2001) 79, 2097-2107. PubMed Europe PubMed
[YEAR:9-7-2001]Donkor,I.O., Zheng,X.Z., Han,J., Lacy,C. and Miller,D.D. Significance of hydrogen bonding at the S(1)' subsite of calpain I Bioorg Med Chem Lett (9-7-2001) 11, 1753-1755. PubMed Europe PubMed DOI I
[YEAR:21-12-2001]Dourdin,N., Bhatt,A.K., Dutt,P., Greer,P.A., Arthur,J.S., Elce,J.S. and Huttenlocher,A. Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts J Biol Chem (21-12-2001) 276, 48382-48388. PubMed Europe PubMed DOI K
Gabrijelcic-Geiger,D., Mentele,R., Meisel,B., Hinz,H., Assfalg-Machleidt,L., Machleidt,W., Moller,A. and Auerswald,E.A. Human micro-calpain: simple isolation from erythrocytes and characterization of autolysis fragments Biol Chem (2001) 382, 1733-1737. PubMed Europe PubMed DOI
Guttmann,R.P., Baker,D.L., Seifert,K.M., Cohen,A.S., Coulter,D.A. and Lynch,D.R. Specific proteolysis of the NR2 subunit at multiple sites by calpain J Neurochem (2001) 78, 1083-1093. PubMed Europe PubMed DOI
[YEAR:8-10-2001]Josef,K.A., Kauer,F.W. and Bihovsky,R. Potent peptide alpha-ketohydroxamate inhibitors of recombinant human calpain I Bioorg Med Chem Lett (8-10-2001) 11, 2615-2617. PubMed Europe PubMed DOI I
[YEAR:9-2-2001]Moldoveanu,T., Hosfield,C.M., Jia,Z., Elce,J.S. and Davies,P.L. Ca(2+)-induced structural changes in rat m-calpain revealed by partial proteolysis Biochim Biophys Acta (9-2-2001) 1545, 245-254. PubMed Europe PubMed DOI
[YEAR:20-7-2001]Nishihara,H., Nakagawa,Y., Ishikawa,H., Ohba,M., Shimizu,K. and Nakamura,T. Matrix vesicles and media vesicles as nonclassical pathways for the secretion of m-calpain from MC3T3-E1 cells Biochem Biophys Res Commun (20-7-2001) 285, 845-853. PubMed Europe PubMed DOI
Purintrapiban,J., Wang,M. and Forsberg,N.E. Identification of glycogen phosphorylase and creatine kinase as calpain substrates in skeletal muscle Int J Biochem Cell Biol (2001) 33, 531-540. PubMed Europe PubMed DOI
Reverter,D., Strobl,S., Fernandez-Catalan,C., Sorimachi,H., Suzuki,K. and Bode,W. Structural basis for possible calcium-induced activation mechanisms of calpains Biol Chem (2001) 382, 753-766. PubMed Europe PubMed DOI
Sato,K. and Kawashima,S. Calpain function in the modulation of signal transduction molecules Biol Chem (2001) 382, 743-751. PubMed Europe PubMed DOI
Tamada,Y., Fukiage,C., Mizutani,K., Yamaguchi,M., Nakamura,Y., Azuma,M. and Shearer,T.R. Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats Curr Eye Res (2001) 22, 280-285. PubMed Europe PubMed DOI I
[YEAR:19-12-2001]Walker,G., Pfeilschifter,J., Otten,U. and Kunz,D. Proteolytic cleavage of inducible nitric oxide synthase (iNOS) by calpain I Biochim Biophys Acta (19-12-2001) 1568, 216-224. PubMed Europe PubMed DOI

2000

Arthur,J.S., Elce,J.S., Hegadorn,C., Williams,K. and Greer,P.A. Disruption of the murine calpain small subunit gene, Capn4: Calpain is essential for embryonic development but not for cell growth and division Mol Cell Biol (2000) 20, 4474-4481. PubMed Europe PubMed DOI PMC EPMC K
Donkor,I.O. A survey of calpain inhibitors Curr Med Chem (2000) 7, 1171-1188. PubMed Europe PubMed I
Jiang,Q.B. and Stys,P.K. Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves J Neurochem (2000) 74, 2101-2107. PubMed Europe PubMed DOI I
[YEAR:18-5-2000]Lee,M.S., Kwon,Y.T., Li,M., Peng,J., Friedlander,R.M. and Tsai,L.H. Neurotoxicity induces cleavage of p35 to p25 by calpain Nature (18-5-2000) 405, 360-364. PubMed Europe PubMed DOI
[YEAR:2-10-2000]Lubisch,W., Hofmann,H.P., Treiber,H.J. and Moller,A. Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors Bioorg Med Chem Lett (2-10-2000) 10, 2187-2191. PubMed Europe PubMed DOI I
[YEAR:7-1-2000]Melloni,E., Averna,M., Salamino,F., Sparatore,B., Minafra,R. and Pontremoli,S. Acyl-CoA-binding protein is a potent m-calpain activator J Biol Chem (7-1-2000) 275, 82-86. PubMed Europe PubMed DOI
[YEAR:21-8-2000]Nakagawa,T. and Yuan,J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis J Cell Biol (21-8-2000) 150, 887-894. PubMed Europe PubMed DOI PMC EPMC
Sakamoto,Y.R., Nakajima,T.R., Fukiage,C.R., Sakai,O.R., Yoshida,Y.R., Azuma,M.R. and Shearer,T.R. Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina Curr Eye Res (2000) 21, 571-580. PubMed Europe PubMed I
Smith,T.P., Casas,E., Rexroad,C.E., III, Kappes,S.M. and Keele,J.W. Bovine CAPN1 maps to a region of BTA29 containing a quantitative trait locus for meat tenderness J Anim Sci (2000) 78, 2589-2594. PubMed Europe PubMed M
[YEAR:19-1-2000]Thompson,V.F., Lawson,K. and Goll,D.E. Effect of mu-calpain on m-calpain Biochem Biophys Res Commun (19-1-2000) 267, 495-499. PubMed Europe PubMed DOI
[YEAR:15-3-2000]Thompson,V.F., Saldana,S., Cong,J. and Goll,D.E. A BODIPY fluorescent microplate assay for measuring activity of calpains and other proteases Anal Biochem (15-3-2000) 279, 170-178. PubMed Europe PubMed DOI A

1999

Ando,R., Sakaki,T., Morinaka,Y., Takahashi,C., Tamao,Y., Yoshii,N., Katayama,S., Saito,K.I., Tokuyama,H., Isaka,M. and Nakamura,E. Cyclopropenone-containing cysteine proteinase inhibitors. Synthesis and enzyme inhibitory activities Bioorg Med Chem (1999) 7, 571-579. PubMed Europe PubMed I
[YEAR:17-12-1999]Croce,K., Flaumenhaft,R., Rivers,M., Furie,B., Furie,B.C., Herman,I.M. and Potter,D.A. Inhibition of calpain blocks platelet secretion, aggregation, and spreading J Biol Chem (17-12-1999) 274, 36321-36327. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:16-8-1999]Peet,N.P., Kim,H.O., Marquart,A.L., Angelastro,M.R., Nieduzak,T.R., White,J.N., Friedrich,D., Flynn,G.A., Webster,M.E., Vaz,R.J., Linnik,M.D., Koehl,J.R., Mehdi,S., Bey,P., Emary,B. and Hwang,K.K. Hydroxyoxazolidines as alpha-aminoacetaldehyde equivalents: novel inhibitors of calpain Bioorg Med Chem Lett (16-8-1999) 9, 2365-2370. PubMed Europe PubMed DOI I
Shumway,S.D., Maki,M. and Miyamoto,S. The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain J Biol Chem (1999) 274, 30874-30881. PubMed Europe PubMed DOI
[YEAR:2-4-1999]Suo,S., Koike,H., Sorimachi,H., Ishiura,S. and Suzuki,K. Association and dissociation of the calcium-binding domains of calpain by Ca2+ Biochem Biophys Res Commun (2-4-1999) 257, 63-66. PubMed Europe PubMed DOI

1998

[YEAR:12-3-1998]Barnoy,S., Glaser,T. and Kosower,N.S. The calpain-calpastatin system and protein degradation in fusing myoblasts Biochim Biophys Acta (12-3-1998) 1402, 52-60. PubMed Europe PubMed DOI I
[YEAR:29-5-1998]Hitomi,K., Uchiyama,Y., Ohkubo,I., Kunimatsu,M., Sasaki,M. and Maki,M. Purification and characterization of the active-site-mutated recombinant human mu-calpain expressed in baculovirus-infected insect cells Biochem Biophys Res Commun (29-5-1998) 246, 681-685. PubMed Europe PubMed DOI E
Kawashima,S., Akanuma,H. and Asaoka,K. Comparison of calpains from rabbit, monkey, human and rat Biol Chem (1998) 379, 201-204. PubMed Europe PubMed
[YEAR:22-5-1998]Melloni,E., Michetti,M., Salamino,F. and Pontremoli,S. Molecular and functional properties of a calpain activator protein specific for mu-isoforms J Biol Chem (22-5-1998) 273, 12827-12831. PubMed Europe PubMed DOI
[YEAR:19-8-1998]Muenchbach,M., Dell'Ambrogio,M. and Gazzotti,P. Proteolysis of liver plectin by mu-calpain Biochem Biophys Res Commun (19-8-1998) 249, 304-306. PubMed Europe PubMed DOI
Poirier,C., Poussard,S., Faust,D.M., Imaizumi-Scherrer,T., Weiss,M.C., Ducastaing,A., Montarras,D., Pinset,C. and Guenet,J.L. Mapping, cloning, cDNA sequence, and expression of the gene encoding the mouse micromolar calpain large subunit (Capn1) Mamm Genome (1998) 9, 388-389. PubMed Europe PubMed DOI
Wells,G.J. and Bihovsky,R. Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments Expert Opin Ther Pat (1998) 8, 1707-1727. V I

1997

Buki,K.G., Bauer,P.I. and Kun,E. Isolation and identification of a proteinase from calf thymus that cleaves poly(ADP-ribose) polymerase and histone H1 Biochim Biophys Acta (1997) 1338, 100-106. PubMed Europe PubMed DOI
[YEAR:7-11-1997]Chatterjee,S., Ator,M.A., Bozyczko-Coyne,D., Josef,K., Wells,G., Tripathy,R., Iqbal,M., Bihovsky,R., Senadhi,S.E., Mallya,S., O'Kane,T.M., McKenna,B.A., Siman,R. and Mallamo,J.P. Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I J Med Chem (7-11-1997) 40, 3820-3828. PubMed Europe PubMed DOI E I
Jeong,S.Y., Sorimachi,H., Lee,H.J., Ishiura,S. and Suzuki,K. Molecular cloning and characterization of cDNAs for the mu-type large subunit and the small subunit of chicken calpain Comp Biochem Physiol B Biochem Mol Biol (1997) 118, 539-547. PubMed Europe PubMed DOI
Schoenwaelder,S.M., Kulkarni,S., Salem,H.H., Imajoh-Ohmi,S., Yamao-Harigaya,W., Saido,T.C. and Jackson,S.P. Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets J Biol Chem (1997) 272, 24876-24884. PubMed Europe PubMed DOI
Stabach,P.R., Cianci,C.D., Glantz,S.B., Zhang,Z. and Morrow,J.S. Site-directed mutagenesis of alphaII spectrin at codon 1175 modulates its mu-calpain susceptibility Biochemistry (1997) 36, 57-65. PubMed Europe PubMed DOI
Vilei,E.M., Calderara,S., Anagli,J., Berardi,S., Hitomi,K., Maki,M. and Carafoli,E. Functional properties of recombinant calpain I and of mutants lacking domains III and IV of the catalytic subunit J Biol Chem (1997) 272, 25802-25808. PubMed Europe PubMed DOI

1996

Baki,A., Tompa,P., Alexa,A., Molnar,O. and Friedrich,P. Autolysis parallels activation of mu-calpain Biochem J (1996) 318, 897-901. PubMed Europe PubMed PMC EPMC
Li,Z., Ortega-Vilain,A.C., Patil,G.S., Chu,D.L., Foreman,J.E., Eveleth,D.D. and Powers,J.C. Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases J Med Chem (1996) 39, 4089-4098. PubMed Europe PubMed DOI I
Melloni,E., Michetti,M., Salamino,F., Minafra,R. and Pontremoli,S. Modulation of the calpain autoproteolysis by calpastatin and phospholipids Biochem Biophys Res Commun (1996) 229, 193-197. PubMed Europe PubMed DOI
Meyer,S.L., Bozyczko-Coyne,D., Mallya,S.K., Spais,C.M., Bihovsky,R., Kaywooya,J.K., Lang,D.M., Scott,R.W. and Siman,R. Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system Biochem J (1996) 314, 511-519. PubMed Europe PubMed PMC EPMC E
Sorimachi,H., Amano,S., Ishiura,S. and Suzuki,K. Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human Biochim Biophys Acta (1996) 1309, 37-41. PubMed Europe PubMed DOI
Tsubuki,S., Saito,Y., Tomioka,M., Ito,H. and Kawashima,S. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine J Biochem (1996) 119, 572-576. PubMed Europe PubMed I

1995

Du,X., Saido,T.C., Tsubuki,S., Indig,F.E., Williams,M.J. and Ginsberg,M.H. Calpain cleavage of the cytoplasmic domain of the integrin beta3 subunit J Biol Chem (1995) 270, 26146-26151. PubMed Europe PubMed DOI
Eto,A., Akita,Y., Saido,T.C., Suzuki,K. and Kawashima,S. The role of the calpain-calpastatin system in thyrotropin-releasing hormone-induced selective down-regulation of a protein kinase C isozyme, nPKC epsilon, in rat pituitary GH4C1 cells J Biol Chem (1995) 270, 25115-25120. PubMed Europe PubMed DOI I
Kim,K., Homma,Y., Ikeuchi,Y. and Suzuki,A. Cleavage of connectin by calpain and cathepsin D Biosci Biotechnol Biochem (1995) 59, 896-899. DOI

1994

Banik,N.L., Chou,C.H., Deibler,G.E., Krutzch,H.C. and Hogan,E.L. Peptide bond specificity of calpain: proteolysis of human myelin basic protein J Neurosci Res (1994) 37, 489-496. PubMed Europe PubMed DOI
Figueiredo-Pereira,M.E., Banik,N. and Wilk,S. Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain J Neurochem (1994) 62, 1989-1994. PubMed Europe PubMed I

1993

[YEAR:3-5-1993]Brown,N. and Crawford,C. Structural modifications associated with the change in Ca2+ sensitivity on activation of m-calpain FEBS Lett (3-5-1993) 322, 65-68. PubMed Europe PubMed DOI
Rosser,B.G., Powers,S.P. and Gores,G.J. Calpain activity increases in hepatocytes following addition of ATP. Demonstration by a novel fluorescent approach J Biol Chem (1993) 268, 23593-23600. PubMed Europe PubMed L
Sun,W., Ji,S.Q., Ebert,P.J., Bidwell,C.A. and Hancock,D.L. Cloning the partial cDNAs of mu-calpain and m-calpain from porcine skeletal muscle Biochimie (1993) 75, 931-936. PubMed Europe PubMed DOI

1992

Goll,D.E., Thompson,V.F., Taylor,R.G. and Zalewska,T. Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin? Bioessays (1992) 14, 549-556. PubMed Europe PubMed DOI
[YEAR:29-5-1992]Huang,Z., McGowan,E.B. and Detwiler,T.C. Ester and amide derivatives of E64c as inhibitors of platelet calpains J Med Chem (29-5-1992) 35, 2048-2054. PubMed Europe PubMed DOI I

1991

Mellgren,R.L. Proteolysis of nuclear proteins by mu-calpain and m-calpain J Biol Chem (1991) 266, 13920-13924. PubMed Europe PubMed

1989

McCelland,P., Lash,J.A. and Hathaway,D.R. Identification of major autolytic cleavage sites in the regulatory subunit of vascular calpain II. A comparison of partial amino-terminal sequences to deduced sequence from complementary DNA J Biol Chem (1989) 264, 17428-17431. PubMed Europe PubMed
Murachi,T. Intracellular regulatory system involving calpain and calpastatin Biochem Int (1989) 18, 263-294. PubMed Europe PubMed

1987

Maki,M., Takano,E., Mori,H., Kannagi,R., Murachi,T. and Hatanaka,M. Repetitive region of calpastatin is a functional unit of the proteinase inhibitor Biochem Biophys Res Commun (1987) 143, 300-308. PubMed Europe PubMed
Minami,Y., Emori,Y., Kawasaki,H. and Suzuki,K. E-F hand structure-domain of calcium-activated neutral protease (CANP) can bind Ca2+ ions J Biochem (1987) 101, 889-895. PubMed Europe PubMed

1986

Aoki,K., Imajoh,S., Ohno,S., Emori,Y., Koike,M., Kosaki,G. and Suzuki,K. Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence FEBS Lett (1986) 205, 313-317. PubMed Europe PubMed
Sasaki,T., Kikuchi,T., Fukui,I. and Murachi,T. Inactivation of calpain I and calpain II by specificity-oriented tripeptidyl chloromethyl ketones J Biochem (1986) 99, 173-179. PubMed Europe PubMed I

1985

Hatanaka,M., Yumoto,N., Sakihama,T. and Murachi,T. Evidence for heterodimeric nature of calpain molecules as studied by cross-linking modification Biochem Int (1985) 10, 187-193. PubMed Europe PubMed
McDermott,J.R., Mantle,D., Biggins,J.A., Kidd,A.M., Davison,K., Lauffart,B. and Pennington,R.J. Specificity of neuropeptide degradation by two calcium-activated neutral proteases from human skeletal muscle Life Sci (1985) 37, 725-730. PubMed Europe PubMed DOI
Sakihama,T., Kakidani,H., Zenita,K., Yumoto,N., Kikuchi,T., Sasaki,T., Kannagi,R., Nakanishi,S., Ohmori,M., Takio,K., Titani,K. and Murachi,T. A putative Ca2+-binding protein: structure of the light subunit of porcine calpain elucidated by molecular cloning and protein sequence analysis Proc Natl Acad Sci U S A (1985) 82, 6075-6079. PubMed Europe PubMed PMC EPMC

1984

[YEAR:25-10-1984]Sasaki,T., Kikuchi,T., Yumoto,N., Yoshimura,N. and Murachi,T. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates J Biol Chem (25-10-1984) 259, 12489-12494. PubMed Europe PubMed
Takano,E., Kitahara,A., Kannagi,R. and Murachi,T. Enzyme immunoassay of calpain I and calpastatin and its application to the analysis of human erythrocyte hemolysate J Appl Biochem (1984) 6, 117-125. PubMed Europe PubMed
[YEAR:1-10-1984]Yoshimura,N., Tsukahara,I. and Murachi,T. Calpain and calpastatin in porcine retina. Identification and action on microtubule-associated proteins Biochem J (1-10-1984) 223, 47-51. PubMed Europe PubMed PMC EPMC

1983

[YEAR:16-3-1983]Cottin,P., Vidalenc,P.L., Merdaci,N. and Ducastaing,A. Evidence for non-competitive inhibition between two calcium-dependent activated neutral proteinases and their specific inhibitor Biochim Biophys Acta (16-3-1983) 743, 299-302. PubMed Europe PubMed
Hatanaka,M., Kikuchi,T. and Murachi,T. Calpain I, a low Ca2+-requiring protease, from human erythrocytes: Purification and subunit structure Biomed Res (1983) 4, 381-388.
Kosaki,G., Tsujinaka,T., Kambayashi,J., Morimoto,K., Yamamoto,K., Yamagami,K., Sobue,K. and Kakiuchi,S. Specific cleavage of calmodulin-binding proteins by low Ca2+-requiring form of Ca2+-activated neutral protease in human platelets Biochem Int (1983) 6, 767-775. PubMed Europe PubMed
Murachi,T. Calpain and calpastatin Trends Biochem Sci (1983) 8, 167-169.
[YEAR:25-7-1983]Yoshimura,N., Kikuchi,T., Sasaki,T., Kitahara,A., Hatanaka,M. and Murachi,T. Two distinct Ca2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney J Biol Chem (25-7-1983) 258, 8883-8889. PubMed Europe PubMed

1982

[YEAR:20-12-1982]Dayton,W.R. Comparison of low- and high-calcium-requiring forms of the calcium-activated protease with their autocatalytic breakdown products Biochim Biophys Acta (20-12-1982) 709, 166-172. PubMed Europe PubMed

1981

De Martino,G.N. Calcium-dependent proteolytic activity in rat liver: identification of two proteases with different calcium requirements Arch Biochem Biophys (1981) 211, 253-257. PubMed Europe PubMed
Murachi,T., Hatanaka,M., Yasumoto,Y., Nayayama,N. and Tanaka,K. A quantitative distribution study on calpain and calpastatin in rat tissues and cells Biochem Int (1981) 2, 651-656.
Murachi,T., Tanaka,K., Hatanaka,M. and Murakami,T. Intracellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin) Adv Enzyme Regul (1981) 19, 407-424.
Murakami,T., Hatanaka,M. and Murachi,T. The cytosol of human erythrocytes contains a highly Ca2+-sensitive thiol protease (calpain I) and its specific inhibitor protein (calpastatin) J Biochem (1981) 90, 1809-1816. PubMed Europe PubMed
Waxman,L. Calcium-activated proteases in mammalian tissues Methods Enzymol (1981) 80, 664-680. PubMed Europe PubMed DOI V

1980

[YEAR:1-1-1980]Mellgren,R.L. Canine cardiac calcium-dependent proteases: resolution of two forms with different requirements for calcium FEBS Lett (1-1-1980) 109, 129-133. PubMed Europe PubMed