Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C01.077: falcipain-1

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

(Topics flags: T Target, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Patra,J., Rana,D., Arora,S., Pal,M. and Mahindroo,N.
    Falcipains: Biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials
    Eur J Med Chem (2023) 252, 115299-115299. PubMed  Europe PubMed DOI
    2. 2020
  2. Rosenthal,P.J.
    Falcipain cysteine proteases of malaria parasites: an update
    Biochim Biophys Acta Proteins Proteom (2020) 1868, 140362-140362. PubMed  Europe PubMed DOI
    3. 2019
  3. Vieira,R.P., Santos,V.C. and Ferreira,R.S.
    Structure-based approaches targeting parasite cysteine proteases
    Curr Med Chem (2019) 26, 4435-4453. PubMed  Europe PubMed DOI  I
    4. 2018
  4. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E.
    Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery
    Curr Drug Targets (2018) 19, 501-526. PubMed  Europe PubMed DOI  I
    5. 2017
  5. Hopp,C.S., Bennett,B.L., Mishra,S., Lehmann,C., Hanson,K.K., Lin,J.W., Rousseau,K., Carvalho,F.A., van der Linden,W.A., Santos,N.C., Bogyo,M., Khan,S.M., Heussler,V. and Sinnis,P.
    Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites
    PLoS Pathog (2017) 13, e1006586-e1006586. PubMed  Europe PubMed DOI  PMC  EPMC  K
  6. Melo,P.M.S., El Chamy Maluf,S., Azevedo,M.F., Paschoalin,T., Budu,A., Bagnaresi,P., Henrique-Silva,F., Soares-Costa,A., Gazarini,M.L. and Carmona,A.K.
    Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4
    Parasitol Int (2017) 67, 233-236. PubMed  Europe PubMed DOI
    7. 2016
  7. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2013
  8. Armada,A., Gazarini,M.L., Goncalves,L.M., Antunes,S., Custodio,A., Rodrigues,A., Almeida,A.J., Silveira,H., Rosario,V.D., Santos-Gomes,G. and Domingos,A.
    Generation of an antibody that recognizes Plasmodium chabaudi cysteine protease (chabaupain-1) in both sexual and asexual parasite life cycle and evaluation of chabaupain-1 vaccine potential
    Exp Parasitol (2013) 135, 166-174. PubMed  Europe PubMed DOI
    9. 2012
  9. Rosenthal,P.J.
    Falcipains
    [ISSN:978-0-12-407743-0] (2012) 3, 1907-1912. DOI
    10. 2011
  10. Rosenthal,P.J.
    Falcipains and other cysteine proteases of malaria parasites
    Adv Exp Med Biol (2011) 712, 30-48. PubMed  Europe PubMed DOI
  11. Teixeira,C., Gomes,J.R.B. and Gomes,P.
    Falcipains, plasmodium falciparum cysteine proteases as key drug targets against malaria
    Curr Med Chem (2011) 18, 1555-1572. PubMed  Europe PubMed DOI  T
    12. 2010
  12. Shah,F., Mukherjee,P., Desai,P. and Avery,M.
    Computational approaches for the discovery of cysteine protease inhibitors against malaria and SARS
    Curr Comput Aided Drug Des (2010) 6, 1-23. PubMed  Europe PubMed DOI  I
    13. 2008
  13. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E.
    Plasmodium food vacuole plasmepsins are activated by falcipains
    J Biol Chem (2008) 283, 12870-12876. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2007
  14. Kumar,A., Kumar,K., Korde,R., Puri,S.K., Malhotra,P. and Singh Chauhan,V.
    Falcipain-1, a Plasmodium falciparum cysteine protease with vaccine potential
    Infect Immun (2007) 75, 2026-2034. PubMed  Europe PubMed DOI  PMC  EPMC  E
    15. 2006
  15. [YEAR:20-7-2006]Sijwali,P.S., Koo,J., Singh,N. and Rosenthal,P.J.
    Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
    Mol Biochem Parasitol (20-7-2006) 150, 96-106. PubMed  Europe PubMed DOI  K
  16. [YEAR:11-4-2006]Verhelst,S.H., Witte,M.D., Arastu-Kapur,S., Fonovic,M. and Bogyo,M.
    Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases
    Chembiochem (11-4-2006) 7, 943-950. PubMed  Europe PubMed DOI  I
    17. 2005
  17. [YEAR:3-1-2005]Coppi,A., Pinzon-Ortiz,C., Hutter,C. and Sinnis,P.
    The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
    J Exp Med (3-1-2005) 201, 27-33. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Florent,I., Lecaille,F., Montagne,J.J., Gauthier,F., Schrevel,J. and Lalmanach,G.
    Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe
    Biol Chem (2005) 386, 401-406. PubMed  Europe PubMed DOI
  19. [YEAR:23-7-2005]Goh,S.L., Goh,L.L. and Sim,T.S.
    Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymes
    Parasitol Res (23-7-2005) 97, 295-301. PubMed  Europe PubMed DOI
    20. 2004
  20. [YEAR:12-3-2004]Bocedi,A., Gradoni,L., Menegatti,E. and Ascenzi,P.
    Kinetics of parasite cysteine proteinase inactivation by NO-donors
    Biochem Biophys Res Commun (12-3-2004) 315, 710-718. PubMed  Europe PubMed DOI
  21. Eksi,S., Czesny,B., Greenbaum,D.C., Bogyo,M. and Williamson,K.C.
    Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth
    Mol Microbiol (2004) 53, 243-250. PubMed  Europe PubMed DOI
  22. [YEAR:15-9-2004]Na,B.K., Kim,T.S., Rosenthal,P.J., Lee,J.K. and Kong,Y.
    Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors
    Parasitol Res (15-9-2004) 94, 312-317. PubMed  Europe PubMed DOI  I
  23. Rosenthal,P.J.
    Falcipains
    [ISSN:0-12-079610-4] (2004) 2, 1157-1160.  V
  24. [YEAR:8-6-2004]Sijwali,P.S., Kato,K., Seydel,K.B., Gut,J., Lehman,J., Klemba,M., Goldberg,D.E., Miller,L.H. and Rosenthal,P.J.
    Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites
    Proc Natl Acad Sci U S A (8-6-2004) 101, 8721-8726. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2002
  25. [YEAR:6-12-2002]Greenbaum,D.C., Baruch,A., Grainger,M., Bozdech,Z., Medzihradszky,K.F., Engel,J., DeRisi,J., Holder,A.A. and Bogyo,M.
    A role for the protease falcipain 1 in host cell invasion by the human malaria parasite
    Science (6-12-2002) 298, 2002-2006. PubMed  Europe PubMed DOI
  26. Malhotra,P., Dasaradhi,P.V., Kumar,A., Mohmmed,A., Agrawal,N., Bhatnagar,R.K. and Chauhan,V.S.
    Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum
    Mol Microbiol (2002) 45, 1245-1254. PubMed  Europe PubMed DOI
    27. 2001
  27. Joachimiak,M.P., Chang,C., Rosenthal,P.J. and Cohen,F.E.
    The impact of whole genome sequence data on drug discovery - a malaria case study
    Mol Med (2001) 7, 698-710. PubMed  Europe PubMed  PMC  EPMC
    28. 2000
  28. Raphael,P., Takakuwa,Y., Manno,S., Liu,S.C., Chishti,A.H. and Hanspal,M.
    A cysteine protease activity from Plasmodium falciparum cleaves human erythrocyte ankyrin
    Mol Biochem Parasitol (2000) 110, 259-272. PubMed  Europe PubMed DOI
    29. 1996
  29. Gamboa de Dominguez,N.D. and Rosenthal,P.J.
    Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites
    Blood (1996) 87, 4448-4454. PubMed  Europe PubMed
  30. Rosenthal,P.J., Olson,J.E., Lee,G.K., Palmer,J.T., Klaus,J.L. and Rasnick,D.
    Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
    Antimicrobial Agents Chemother (1996) 40, 1600-1603. PubMed  Europe PubMed  PMC  EPMC  I
    31. 1994
  31. Rosenthal,P.J., Ring,C.S., Chen,X. and Cohen,F.E.
    Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases
    J Mol Biol (1994) 241, 312-316. PubMed  Europe PubMed DOI
    32. 1993
  32. Rosenthal,P.J.
    A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue
    Biochim Biophys Acta (1993) 1173, 91-93. PubMed  Europe PubMed DOI
    33. 1992
  33. Rosenthal,P.J. and Nelson,R.G.
    Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum
    Mol Biochem Parasitol (1992) 51, 143-152. PubMed  Europe PubMed DOI
    34. 1987
  34. [YEAR:1-9-1987]Rosenthal,P.J., Kim,K., McKerrow,J.H. and Leech,J.H.
    Identification of three stage-specific proteinases of Plasmodium falciparum
    J Exp Med (1-9-1987) 166, 816-821. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use