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Literature for peptidase C01.077: falcipain-1

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: T Target, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Patra,J., Rana,D., Arora,S., Pal,M. and Mahindroo,N.
    Falcipains: Biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials
    Eur J Med Chem252, 115299-115299. PubMed  Europe PubMed DOI
    2. 2020
  2. Rosenthal,P.J.
    Falcipain cysteine proteases of malaria parasites: an update
    Biochim Biophys Acta Proteins Proteom1868, 140362-140362. PubMed  Europe PubMed DOI
    3. 2019
  3. Vieira,R.P., Santos,V.C. and Ferreira,R.S.
    Structure-based approaches targeting parasite cysteine proteases
    Curr Med Chem26, 4435-4453. PubMed  Europe PubMed DOI  I
    4. 2018
  4. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E.
    Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery
    Curr Drug Targets19, 501-526. PubMed  Europe PubMed DOI  I
    5. 2017
  5. Hopp,C.S., Bennett,B.L., Mishra,S., Lehmann,C., Hanson,K.K., Lin,J.W., Rousseau,K., Carvalho,F.A., van der Linden,W.A., Santos,N.C., Bogyo,M., Khan,S.M., Heussler,V. and Sinnis,P.
    Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites
    PLoS Pathog13, e1006586-e1006586. PubMed  Europe PubMed DOI  K
  6. Melo,P.M.S., El Chamy Maluf,S., Azevedo,M.F., Paschoalin,T., Budu,A., Bagnaresi,P., Henrique-Silva,F., Soares-Costa,A., Gazarini,M.L. and Carmona,A.K.
    Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4
    Parasitol Int67, 233-236. PubMed  Europe PubMed DOI
    7. 2016
  7. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J15, 51-51. PubMed  Europe PubMed DOI
    8. 2013
  8. Armada,A., Gazarini,M.L., Goncalves,L.M., Antunes,S., Custodio,A., Rodrigues,A., Almeida,A.J., Silveira,H., Rosario,V.D., Santos-Gomes,G. and Domingos,A.
    Generation of an antibody that recognizes Plasmodium chabaudi cysteine protease (chabaupain-1) in both sexual and asexual parasite life cycle and evaluation of chabaupain-1 vaccine potential
    Exp Parasitol135, 166-174. PubMed  Europe PubMed DOI
    9. 2012
  9. Rosenthal,P.J.
    Falcipains
    [ISSN:978-0-12-407743-0]3, 1907-1912. DOI
    10. 2011
  10. Rosenthal,P.J.
    Falcipains and other cysteine proteases of malaria parasites
    Adv Exp Med Biol712, 30-48. PubMed  Europe PubMed DOI
  11. Teixeira,C., Gomes,J.R.B. and Gomes,P.
    Falcipains, plasmodium falciparum cysteine proteases as key drug targets against malaria
    Curr Med Chem18, 1555-1572. PubMed  Europe PubMed DOI  T
    12. 2010
  12. Shah,F., Mukherjee,P., Desai,P. and Avery,M.
    Computational approaches for the discovery of cysteine protease inhibitors against malaria and SARS
    Curr Comput Aided Drug Des6, 1-23. PubMed  Europe PubMed DOI  I
    13. 2008
  13. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E.
    Plasmodium food vacuole plasmepsins are activated by falcipains
    J Biol Chem283, 12870-12876. PubMed  Europe PubMed DOI
    14. 2007
  14. Kumar,A., Kumar,K., Korde,R., Puri,S.K., Malhotra,P. and Singh Chauhan,V.
    Falcipain-1, a Plasmodium falciparum cysteine protease with vaccine potential
    Infect Immun75, 2026-2034. PubMed  Europe PubMed DOI  E
    15. 2006
  15. [YEAR:20-7-2006]Sijwali,P.S., Koo,J., Singh,N. and Rosenthal,P.J.
    Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
    Mol Biochem Parasitol150, 96-106. PubMed  Europe PubMed DOI  K
  16. [YEAR:11-4-2006]Verhelst,S.H., Witte,M.D., Arastu-Kapur,S., Fonovic,M. and Bogyo,M.
    Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases
    Chembiochem7, 943-950. PubMed  Europe PubMed DOI  I
    17. 2005
  17. [YEAR:3-1-2005]Coppi,A., Pinzon-Ortiz,C., Hutter,C. and Sinnis,P.
    The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
    J Exp Med201, 27-33. PubMed  Europe PubMed DOI
  18. Florent,I., Lecaille,F., Montagne,J.J., Gauthier,F., Schrevel,J. and Lalmanach,G.
    Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe
    Biol Chem386, 401-406. PubMed  Europe PubMed DOI
  19. [YEAR:23-7-2005]Goh,S.L., Goh,L.L. and Sim,T.S.
    Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymes
    Parasitol Res97, 295-301. PubMed  Europe PubMed DOI
    20. 2004
  20. [YEAR:12-3-2004]Bocedi,A., Gradoni,L., Menegatti,E. and Ascenzi,P.
    Kinetics of parasite cysteine proteinase inactivation by NO-donors
    Biochem Biophys Res Commun315, 710-718. PubMed  Europe PubMed DOI
  21. Eksi,S., Czesny,B., Greenbaum,D.C., Bogyo,M. and Williamson,K.C.
    Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth
    Mol Microbiol53, 243-250. PubMed  Europe PubMed DOI
  22. [YEAR:15-9-2004]Na,B.K., Kim,T.S., Rosenthal,P.J., Lee,J.K. and Kong,Y.
    Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors
    Parasitol Res94, 312-317. PubMed  Europe PubMed DOI  I
  23. Rosenthal,P.J.
    Falcipains
    [ISSN:0-12-079610-4]2, 1157-1160.  V
  24. [YEAR:8-6-2004]Sijwali,P.S., Kato,K., Seydel,K.B., Gut,J., Lehman,J., Klemba,M., Goldberg,D.E., Miller,L.H. and Rosenthal,P.J.
    Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites
    Proc Natl Acad Sci U S A101, 8721-8726. PubMed  Europe PubMed DOI
    25. 2002
  25. [YEAR:6-12-2002]Greenbaum,D.C., Baruch,A., Grainger,M., Bozdech,Z., Medzihradszky,K.F., Engel,J., DeRisi,J., Holder,A.A. and Bogyo,M.
    A role for the protease falcipain 1 in host cell invasion by the human malaria parasite
    Science298, 2002-2006. PubMed  Europe PubMed DOI
  26. Malhotra,P., Dasaradhi,P.V., Kumar,A., Mohmmed,A., Agrawal,N., Bhatnagar,R.K. and Chauhan,V.S.
    Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum
    Mol Microbiol45, 1245-1254. PubMed  Europe PubMed DOI
    27. 2001
  27. Joachimiak,M.P., Chang,C., Rosenthal,P.J. and Cohen,F.E.
    The impact of whole genome sequence data on drug discovery - a malaria case study
    Mol Med7, 698-710. PubMed  Europe PubMed
    28. 2000
  28. Raphael,P., Takakuwa,Y., Manno,S., Liu,S.C., Chishti,A.H. and Hanspal,M.
    A cysteine protease activity from Plasmodium falciparum cleaves human erythrocyte ankyrin
    Mol Biochem Parasitol110, 259-272. PubMed  Europe PubMed DOI
    29. 1996
  29. Gamboa de Dominguez,N.D. and Rosenthal,P.J.
    Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites
    Blood87, 4448-4454. PubMed  Europe PubMed
  30. Rosenthal,P.J., Olson,J.E., Lee,G.K., Palmer,J.T., Klaus,J.L. and Rasnick,D.
    Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
    Antimicrobial Agents Chemother40, 1600-1603. PubMed  Europe PubMed  I
    31. 1994
  31. Rosenthal,P.J., Ring,C.S., Chen,X. and Cohen,F.E.
    Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases
    J Mol Biol241, 312-316. PubMed  Europe PubMed DOI
    32. 1993
  32. Rosenthal,P.J.
    A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue
    Biochim Biophys Acta1173, 91-93. PubMed  Europe PubMed DOI
    33. 1992
  33. Rosenthal,P.J. and Nelson,R.G.
    Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum
    Mol Biochem Parasitol51, 143-152. PubMed  Europe PubMed DOI
    34. 1987
  34. [YEAR:1-9-1987]Rosenthal,P.J., Kim,K., McKerrow,J.H. and Leech,J.H.
    Identification of three stage-specific proteinases of Plasmodium falciparum
    J Exp Med166, 816-821. PubMed  Europe PubMed

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