$VAR1 = undef;
Summary for peptidase C01.077: falcipain-1
| Names | |
|---|---|
| MEROPS Name | falcipain-1 |
| Other names | berghepain-1 (Plasmodium berghei), chabaupain-1 (Plasmodium chabaudi), vinckepain-1 (Plasmodium vinvkei), vivapain-1 (Plasmodium vivax) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.077 |
| Holotype | falcipain-1 (Plasmodium falciparum), Uniprot accession P25805 (peptidase unit: 337-569), MERNUM MER0000675 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Physiology | Malarial parasite development and nutrition. | ||
| Pharmaceutical relevance | Specific inhibitors blocked parasite invasion of host erythrocytes (Greenbaum et al., 2002), and falcipain-1 is therefore a potential drug target for malaria. | ||
| Other databases | PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR12411:SF414 | |
