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Literature for peptidase C01.072: rhodesain

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sheu-Idrees,R., Marques,G.V.L., Santana,P.A.L., Diniz,L.A., Resende,D.M., Odoma,S., Olorunshola,O., Ferreira,R.S., Murta,S.M.F., Maltarollo,V.G. and de Oliveira,R.B.
    Investigation of the activity of 4-aminoquinolines as cysteine protease inhibitors with application in the treatment of Chagas disease
    Mem Inst Oswaldo Cruz120, e240161-e240161. PubMed  Europe PubMed DOI  I
    2. 2024
  2. Di Chio,C., Starvaggi,J., Totaro,N., Previti,S., Natale,B., Cosconati,S., Bogacz,M., Schirmeister,T., Legac,J., Rosenthal,P.J., Zappala,M. and Ettari,R.
    Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria
    Int J Mol Sci25, PubMed  Europe PubMed DOI  I
    3. 2023
  3. Ettari,R.
    Cysteine Proteases as Validated Targets for the Treatment of Neglected and Poverty-Related Parasitic Diseases
    Int J Mol Sci24, PubMed  Europe PubMed DOI
    4. 2022
  4. Di Chio,C., Previti,S., Amendola,G., Ravichandran,R., Wagner,A., Cosconati,S., Hellmich,U.A., Schirmeister,T., Zappala,M. and Ettari,R.
    Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense
    Eur J Med Chem236, 114328-114328. PubMed  Europe PubMed DOI
  5. Elrufaie,H.A., Mohamed,L.M., Hamd,A.Y., Bala,N.A., Elbadawi,F.A., Ghaboosh,H. and Alzain,A.A.
    Discovery of novel natural products as rhodesain inhibitors for human African trypanosomiasis using in silico techniques
    J Biomol Struct Dyn1-13. PubMed  Europe PubMed DOI
    6. 2021
  6. Arafet,K., Gonzalez,F.V. and Moliner,V.
    Elucidating the dual mode of action of dipeptidyl enoates in the inhibition of rhodesain cysteine proteases
    Chemistry PubMed  Europe PubMed DOI
  7. Barbosa da Silva,E., Rocha,D.A., Fortes,I.S., Yang,W., Monti,L., Siqueira-Neto,J.L., Caffrey,C.R., McKerrow,J., Andrade,S.F. and Ferreira,R.S.
    Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors
    J Med Chem64, 13054-13071. PubMed  Europe PubMed DOI  I
  8. Di Chio,C., Previti,S., De Luca,F., Allegra,A., Zappala,M. and Ettari,R.
    Drug combination studies of PS-1 and quercetin against rhodesain of Trypanosoma brucei rhodesiense
    Nat Prod Res1-5. PubMed  Europe PubMed DOI  I
  9. Johe,P., Jung,S., Endres,E., Kersten,C., Zimmer,C., Ye,W., Sonnichsen,C., Hellmich,U.A., Sotriffer,C., Schirmeister,T. and Neuweiler,H.
    Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain
    ACS Chem Biol16, 661-670. PubMed  Europe PubMed DOI
  10. Johe,P., Jaenicke,E., Neuweiler,H., Schirmeister,T., Kersten,C. and Hellmich,U.A.
    Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes
    J Biol Chem100565-100565. PubMed  Europe PubMed DOI
  11. Nakamura,Y., Hayashida,K., Delesalle,V., Qiu,Y., Omori,R., Simuunza,M., Sugimoto,C., Namangala,B. and Yamagishi,J.
    Genetic Diversity of African Trypanosomes in Tsetse Flies and Cattle From the Kafue Ecosystem
    Front Vet Sci8, 599815-599815. PubMed  Europe PubMed DOI
  12. Santos Nascimento,I.J.D., de Aquino,T.M. and da Silva-Junior,E.F.
    Cruzain and Rhodesain Inhibitors: Last Decade of Advances in Seeking for New Compounds Against American and African Trypanosomiases
    Curr Top Med Chem PubMed  Europe PubMed DOI  V
    13. 2020
  13. Alvarez,V.E., Iribarren,P.A., Niemirowicz,G.T. and Cazzulo,J.J.
    Update on relevant trypanosome peptidases: Validated targets and future challenges
    Biochim Biophys Acta Proteins Proteom1869, 140577-140577. PubMed  Europe PubMed DOI
  14. Arafet,K., Gonzalez,F.V. and Moliner,V.
    Quantum mechanics/molecular mechanics studies of the mechanism of cysteine proteases inhibition by dipeptidyl nitroalkenes
    Chemistry26, 2002-2012. PubMed  Europe PubMed DOI  I
  15. da Costa,C.H.S., Bonatto,V., Dos Santos,A.M., Lameira,J., Leitao,A. and Montanari,C.A.
    Evaluating QM/MM free energy surfaces for ranking cysteine protease covalent inhibitors
    J Chem Inf Model60, 880-889. PubMed  Europe PubMed DOI  I
  16. Di Chio,C., Previti,S., Amendola,G., Cosconati,S., Schirmeister,T., Zappala,M. and Ettari,R.
    Development of novel benzodiazepine-based peptidomimetics as inhibitors of rhodesain from Trypanosoma brucei rhodesiense
    ChemMedChem15, 995-1001. PubMed  Europe PubMed DOI  I
  17. Ettari,R., Previti,S., Di Chio,C., Maiorana,S., Allegra,A., Schirmeister,T. and Zappala,M.
    Drug synergism: studies of combination of RK-52 and curcumin against rhodesain of Trypanosoma brucei rhodesiense
    ACS Med Chem Lett11, 806-810. PubMed  Europe PubMed DOI  I
  18. Klein,P., Barthels,F., Johe,P., Wagner,A., Tenzer,S., Distler,U., Le,T.A., Schmid,P., Engel,V., Engels,B., Hellmich,U.A., Opatz,T. and Schirmeister,T.
    Naphthoquinones as covalent reversible inhibitors of cysteine proteases: studies on inhibition mechanism and kineticsNaphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases: Studies on Inhibition Mechanism and Kinetics
    Molecules25, PubMed  Europe PubMed DOI  I
  19. Klein,P., Johe,P., Wagner,A., Jung,S., Kuhlborn,J., Barthels,F., Tenzer,S., Distler,U., Waigel,W., Engels,B., Hellmich,U.A., Opatz,T. and Schirmeister,T.
    New cysteine protease inhibitors: electrophilic (het)arenes and unexpected prodrug identification for the Trypanosoma protease rhodesain
    Molecules25, PubMed  Europe PubMed DOI  I
    20. 2019
  20. Cianni,L., Feldmann,C.W., Gilberg,E., Gutschow,M., Juliano,L., Leitao,A., Bajorath,J. and Montanari,C.A.
    Can cysteine protease cross-class inhibitors achieve selectivity?
    J Med Chem62, 10497-10525. PubMed  Europe PubMed DOI  I
  21. Ettari,R., Previti,S., Maiorana,S., Allegra,A., Schirmeister,T., Grasso,S. and Zappala,M.
    Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense
    Nat Prod Res33, 3577-3581. PubMed  Europe PubMed DOI  I
  22. Santos,L.H., Waldner,B.J., Fuchs,J.E., Pereira,G.A.N., Liedl,K.R., Caffarena,E.R. and Ferreira,R.S.
    Understanding structure-activity relationships for trypanosomal cysteine protease inhibitors by simulations and free energy calculations
    J Chem Inf Model59, 137-148. PubMed  Europe PubMed DOI  I
  23. Steverding,D.
    On the reversible and irreversible inhibition of rhodesain by curcumin
    Molecules25, PubMed  Europe PubMed DOI  I
    24. 2018
  24. Eyssen,L.E., Vather,P., Jackson,L., Ximba,P., Biteau,N., Baltz,T., Boulange,A., Buscher,P. and Coetzer,T.H.T.
    Recombinant and native TviCATL from Trypanosoma vivax: enzymatic characterisation and evaluation as a diagnostic target for animal African trypanosomosis
    Mol Biochem Parasitol223, 50-54. PubMed  Europe PubMed DOI
  25. Giroud,M., Dietzel,U., Anselm,L., Banner,D., Kuglstatter,A., Benz,J., Blanc,J.B., Gaufreteau,D., Liu,H., Lin,X., Stich,A., Kuhn,B., Schuler,F., Kaiser,M., Brun,R., Schirmeister,T., Kisker,C., Diederich,F. and Haap,W.
    Repurposing a library of human cathepsin L ligands: identification of macrocyclic lactams as potent rhodesain and Trypanosoma brucei inhibitors
    J Med Chem61, 3350-3369. PubMed  Europe PubMed DOI  S  I
  26. Giroud,M., Kuhn,B., Saint-Auret,S., Kuratli,C., Martin,R.E., Schuler,F., Diederich,F., Kaiser,M., Brun,R., Schirmeister,T. and Haap,W.
    2 H-1,2,3-Triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design
    J Med Chem61, 3370-3388. PubMed  Europe PubMed DOI  I
  27. Macedo Koeller,C. and Bangs,J.D.
    Processing and targeting of cathepsin L (TbCatL) to the lysosome in Trypanosoma brucei
    Cell Microbiole12980-e12980. PubMed  Europe PubMed DOI
  28. Rocha,D.A., Silva,E.B., Fortes,I.S., Lopes,M.S., Ferreira,R.S. and Andrade,S.F.
    Synthesis and structure-activity relationship studies of cruzain and rhodesain inhibitors
    Eur J Med Chem157, 1426-1459. PubMed  Europe PubMed DOI  I
  29. Royo,S., Schirmeister,T., Kaiser,M., Jung,S., Rodriguez,S., Bautista,J.M. and Gonzalez,F.V.
    Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates
    Bioorg Med Chem26, 4624-4634. PubMed  Europe PubMed DOI  I
    30. 2017
  30. Ferreira,L.G. and Andricopulo,A.D.
    Targeting cysteine proteases in trypanosomatid disease drug discovery
    Pharmacol Ther180, 49-61. PubMed  Europe PubMed DOI  T
  31. Giroud,M., Ivkovic,J., Martignoni,M., Fleuti,M., Trapp,N., Haap,W., Kuglstatter,A., Benz,J., Kuhn,B., Schirmeister,T. and Diederich,F.
    Inhibition of the cysteine protease human cathepsin L by triazine nitriles: amide???heteroarene pi-stacking interactions and chalcogen bonding in the S3 pocket
    ChemMedChem12, 257-270. PubMed  Europe PubMed DOI  I
  32. Previti,S., Ettari,R., Cosconati,S., Amendola,G., Chouchene,K., Wagner,A., Hellmich,U.A., Ulrich,K., Krauth-Siegel,R.L., Wich,P.R., Schmid,I., Schirmeister,T., Gut,J., Rosenthal,P.J., Grasso,S. and Zappala,M.
    Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of neglected tropical diseases (NTDs)
    J Med Chem60, 6911-6923. PubMed  Europe PubMed DOI  I
  33. Schirmeister,T., Schmitz,J., Jung,S., Schmenger,T., Krauth-Siegel,R.L. and Gutschow,M.
    Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei
    Bioorg Med Chem Lett27, 45-50. PubMed  Europe PubMed DOI  I
    34. 2016
  34. Ettari,R., Previti,S., Cosconati,S., Kesselring,J., Schirmeister,T., Grasso,S. and Zappala,M.
    Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors
    J Enzyme Inhib Med Chem31, 1184-1191. PubMed  Europe PubMed DOI  I
  35. Ettari,R., Previti,S., Tamborini,L., Cullia,G., Grasso,S. and Zappala,M.
    The inhibition of cysteine proteases rhodesain and TbCatB: a valuable approach to treat human African trypanosomiasis
    Mini Rev Med Chem16, 1374-1391. PubMed  Europe PubMed DOI  V  I
  36. Latorre,A., Schirmeister,T., Kesselring,J., Jung,S., Johe,P., Hellmich,U.A., Heilos,A., Engels,B., Krauth-Siegel,R.L., Dirdjaja,N., Bou-Iserte,L., Rodriguez,S. and Gonzalez,F.V.
    Dipeptidyl nitroalkenes as potent reversible inhibitors of cysteine proteases rhodesain and cruzain
    ACS Med Chem Lett7, 1073-1076. PubMed  Europe PubMed DOI  I
    37. 2015
  37. Ettari,R., Pinto,A., Previti,S., Tamborini,L., Angelo,I.C., La Pietra,V., Marinelli,L., Novellino,E., Schirmeister,T., Zappala,M., Grasso,S., De Micheli,C. and Conti,P.
    Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation
    Bioorg Med Chem23, 7053-7060. PubMed  Europe PubMed DOI  I
  38. Fonseca,N.C., da Cruz,L.F., da Silva Villela,F., do Nascimento Pereira,G.A., de Siqueira-Neto,J.L., Kellar,D., Suzuki,B.M., Ray,D., de Souza,T.B., Alves,R.J., Junior,P.A., Romanha,A.J., Murta,S.M., McKerrow,J.H., Caffrey,C.R., de Oliveira,R.B. and Ferreira,R.S.
    Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1
    Antimicrob Agents Chemother59, 2666-2677. PubMed  Europe PubMed DOI  I
  39. McShan,D., Kathman,S., Lowe,B., Xu,Z., Zhan,J., Statsyuk,A. and Ogungbe,I.V.
    Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain
    Bioorg Med Chem Lett25, 4509-4512. PubMed  Europe PubMed DOI  I
  40. Royo,S., Rodriguez,S., Schirmeister,T., Kesselring,J., Kaiser,M. and Gonzalez,F.V.
    Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action
    ChemMedChem10, 1484-1487. PubMed  Europe PubMed DOI  I
    41. 2014
  41. Alsford,S., Currier,R.B., Guerra-Assuncao,J.A., Clark,T.G. and Horn,D.
    Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei
    PLoS Pathog10, e1004130-e1004130. PubMed  Europe PubMed DOI
  42. Ettari,R., Pinto,A., Tamborini,L., Angelo,I.C., Grasso,S., Zappala,M., Capodicasa,N., Yzeiraj,L., Gruber,E., Aminake,M.N., Pradel,G., Schirmeister,T., De Micheli,C. and Conti,P.
    Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents
    ChemMedChem9, 1817-1825. PubMed  Europe PubMed DOI  I
    43. 2013
  43. Ehmke,V., Winkler,E., Banner,D.W., Haap,W., Schweizer,W.B., Rottmann,M., Kaiser,M., Freymond,C., Schirmeister,T. and Diederich,F.
    Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L
    ChemMedChem8, 967-975. PubMed  Europe PubMed DOI  I
  44. Elliott,E.B., McCarroll,D., Hasumi,H., Welsh,C.E., Panissidi,A.A., Jones,N.G., Rossor,C.L., Tait,A., Smith,G.L., Mottram,J.C., Morrison,L.J. and Loughrey,C.M.
    Trypanosoma brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes
    Cardiovasc Res100, 325-335. PubMed  Europe PubMed DOI
  45. Ettari,R., Tamborini,L., Angelo,I.C., Micale,N., Pinto,A., De Micheli,C. and Conti,P.
    Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis
    J Med Chem56, 5637-5658. PubMed  Europe PubMed DOI  I
  46. Ettari,R., Tamborini,L., Angelo,I.C., Grasso,S., Schirmeister,T., Lo Presti,L., De Micheli,C., Pinto,A. and Conti,P.
    Development of rhodesain inhibitors with a 3-bromoisoxazoline warhead
    ChemMedChem8, 2070-2076. PubMed  Europe PubMed DOI  I
    47. 2012
  47. Costa,T.F., Reis,F.C. and Lima,A.P.
    Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L
    Biochim Biophys Acta1824, 493-501. PubMed  Europe PubMed DOI
  48. Ehmke,V., Quinsaat,J.E., Rivera-Fuentes,P., Heindl,C., Freymond,C., Rottmann,M., Brun,R., Schirmeister,T. and Diederich,F.
    Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors
    Org Biomol Chem10, 5764-5768. PubMed  Europe PubMed DOI  I
  49. Steverding,D., Sexton,D.W., Wang,X., Gehrke,S.S., Wagner,G.K. and Caffrey,C.R.
    Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target
    Int J Parasitol42, 481-488. PubMed  Europe PubMed DOI  I
  50. Yang,P.Y., Wang,M., Li,L., Wu,H., He,C.Y. and Yao,S.Q.
    Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents
    Chemistry18, 6528-6541. PubMed  Europe PubMed DOI  I
    51. 2011
  51. Caffrey,C.R., Lima,A.P. and Steverding,D.
    Cysteine peptidases of kinetoplastid parasites
    Adv Exp Med Biol712, 84-99. PubMed  Europe PubMed DOI  V
  52. Ehmke,V., Heindl,C., Rottmann,M., Freymond,C., Schweizer,W.B., Brun,R., Stich,A., Schirmeister,T. and Diederich,F.
    Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei
    ChemMedChem6, 273-278. PubMed  Europe PubMed DOI  I
    53. 2010
  53. Breuning,A., Degel,B., Schulz,F., Buchold,C., Stempka,M., Machon,U., Heppner,S., Gelhaus,C., Leippe,M., Leyh,M., Kisker,C., Rath,J., Stich,A., Gut,J., Rosenthal,P.J., Schmuck,C. and Schirmeister,T.
    Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids
    J Med Chem53, 1951-1963. PubMed  Europe PubMed DOI  I
  54. Ettari,R., Zappala,M., Micale,N., Schirmeister,T., Gelhaus,C., Leippe,M., Evers,A. and Grasso,S.
    Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain
    Eur J Med Chem45, 3228-3233. PubMed  Europe PubMed DOI  I
  55. Kerr,I.D., Wu,P., Marion-Tsukamaki,R., Mackey,Z.B. and Brinen,L.S.
    Crystal structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei
    PLoS Negl Trop Dis4, e701-e701. PubMed  Europe PubMed DOI  S
  56. Mott,B.T., Ferreira,R.S., Simeonov,A., Jadhav,A., Ang,K.K., Leister,W., Shen,M., Silveira,J.T., Doyle,P.S., Arkin,M.R., McKerrow,J.H., Inglese,J., Austin,C.P., Thomas,C.J., Shoichet,B.K. and Maloney,D.J.
    Identification and optimization of inhibitors of trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB
    J Med Chem53, 52-60. PubMed  Europe PubMed DOI  S  I
  57. Waag,T., Gelhaus,C., Rath,J., Stich,A., Leippe,M. and Schirmeister,T.
    Allicin and derivates are cysteine protease inhibitors with antiparasitic activity
    Bioorg Med Chem Lett20, 5541-5543. PubMed  Europe PubMed DOI  I
    58. 2009
  58. Caffrey,C.R. and Steverding,D.
    Kinetoplastid papain-like cysteine peptidases
    Mol Biochem Parasitol167, 12-19. PubMed  Europe PubMed DOI  I
  59. Cortez,A.P., Rodrigues,A.C., Garcia,H.A., Neves,L., Batista,J.S., Bengaly,Z., Paiva,F. and Teixeira,M.M.
    Cathepsin L-like genes of Trypanosoma vivax from Africa and South America - characterization, relationships and diagnostic implications
    Mol Cell Probes23, 44-51. PubMed  Europe PubMed DOI
  60. Kerr,I.D., Lee,J.H., Farady,C.J., Marion,R., Rickert,M., Sajid,M., Pandey,K.C., Caffrey,C.R., Legac,J., Hansell,E., McKerrow,J.H., Craik,C.S., Rosenthal,P.J. and Brinen,L.S.
    Vinyl sulfones as antiparasitic agents and a structural basis for drug design
    J Biol Chem284, 25697-25703. PubMed  Europe PubMed DOI  S  I
  61. Steverding,D., Wang,X. and Sexton,D.W.
    The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei
    Parasitol Res105, 1333-1338. PubMed  Europe PubMed DOI
    62. 2008
  62. Abdulla,M.H., O'Brien,T., Mackey,Z.B., Sajid,M., Grab,D.J. and McKerrow,J.H.
    RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model
    PLoS Negl Trop Dis2, e298-e298. PubMed  Europe PubMed DOI
  63. Jaishankar,P., Hansell,E., Zhao,D.M., Doyle,P.S., McKerrow,J.H. and Renslo,A.R.
    Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes
    Bioorg Med Chem Lett18, 624-628. PubMed  Europe PubMed DOI  I
  64. Mallari,J.P., Shelat,A., Kosinski,A., Caffrey,C.R., Connelly,M., Zhu,F., McKerrow,J.H. and Guy,R.K.
    Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB
    Bioorg Med Chem Lett18, 2883-2885. PubMed  Europe PubMed DOI  I
    65. 2007
  65. Gonzalez,F.V., Izquierdo,J., Rodriguez,S., McKerrow,J.H. and Hansell,E.
    Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain
    Bioorg Med Chem Lett17, 6697-6700. PubMed  Europe PubMed DOI  I
  66. Reis,F.C., Costa,T.F., Sulea,T., Mezzetti,A., Scharfstein,J., Bromme,D., Menard,R. and Lima,A.P.
    The propeptide of cruzipain - a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F
    FEBS J274, 1224-1234. PubMed  Europe PubMed DOI
    67. 2006
  67. [YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.
    Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
    J Biol Chem281, 12824-12832. PubMed  Europe PubMed DOI  P
  68. [YEAR:2-10-2006]Nikolskaia,O.V., de,A.L., Kim,Y.V., Lonsdale-Eccles,J.D., Fukuma,T., Scharfstein,J. and Grab,D.J.
    Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
    J Clin Invest116, 2739-2747. PubMed  Europe PubMed DOI  I
  69. [YEAR:1-3-2006]Vicik,R., Hoerr,V., Glaser,M., Schultheis,M., Hansell,E., McKerrow,J.H., Holzgrabe,U., Caffrey,C.R., Ponte-Sucre,A., Moll,H., Stich,A. and Schirmeister,T.
    Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents
    Bioorg Med Chem Lett16, 2753-2757. PubMed  Europe PubMed DOI  I
    70. 2005
  70. [YEAR:3-1-2005]Fujii,N., Mallari,J.P., Hansell,E.J., Mackey,Z., Doyle,P., Zhou,Y.M., Gut,J., Rosenthal,P.J., McKerrow,J.H. and Guy,R.K.
    Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain
    Bioorg Med Chem Lett15, 121-123. PubMed  Europe PubMed DOI  I
  71. [YEAR:10-2-2005]Gosalia,D.N., Salisbury,C.M., Ellman,J.A. and Diamond,S.L.
    High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays
    Mol Cell Proteomics4, 626-636. PubMed  Europe PubMed DOI
    72. 2003
  72. [YEAR:20-10-2003]Chiyanzu,I., Hansell,E., Gut,J., Rosenthal,P.J., McKerrow,J.H. and Chibale,K.
    Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain
    Bioorg Med Chem Lett13, 3527-3530. PubMed  Europe PubMed DOI  I
    73. 2001
  73. Caffrey,C.R., Hansell,E., Lucas,K.D., Brinen,L.S., Hernandez,A.A., Cheng,J.N., Gwaltney,S.L., II, Roush,W.R., Stierhof,Y.D., Bogyo,M., Steverding,D. and McKerrow,J.H.
    Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
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