Literature for peptidase C01.072: rhodesain

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Sheu-Idrees,R., Marques,G.V.L., Santana,P.A.L., Diniz,L.A., Resende,D.M., Odoma,S., Olorunshola,O., Ferreira,R.S., Murta,S.M.F., Maltarollo,V.G. and de Oliveira,R.B. Investigation of the activity of 4-aminoquinolines as cysteine protease inhibitors with application in the treatment of Chagas disease Mem Inst Oswaldo Cruz (2025) 120, e240161-e240161. PubMed Europe PubMed DOI PMC EPMC I

2024

Di Chio,C., Starvaggi,J., Totaro,N., Previti,S., Natale,B., Cosconati,S., Bogacz,M., Schirmeister,T., Legac,J., Rosenthal,P.J., Zappala,M. and Ettari,R. Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC I
Nunes,J.A., Santos-Junior,P.F.D.S., Gomes,M.C., Ferreira,L.A.S., Padilha,E.K.A., Teixeira,T.R., Stanger,E.J., Kaur,Y., Silva,E.B.D., Costa,C.A.C.B., Freitas,J.D., Araujo-Junior,J.X., Mendonca-Junior,F.J.B., Giardini,M.A., Siqueira-Neto,J.L., Caffrey,C.R., Zhan,P., Cardoso,S.H. and Silva-Junior,E.F.D. Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease Eur J Med Chem (2024) 283, 117109-117109. PubMed Europe PubMed DOI I

2023

Ettari,R. Cysteine Proteases as Validated Targets for the Treatment of Neglected and Poverty-Related Parasitic Diseases Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC

2022

Di Chio,C., Previti,S., Amendola,G., Ravichandran,R., Wagner,A., Cosconati,S., Hellmich,U.A., Schirmeister,T., Zappala,M. and Ettari,R. Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense Eur J Med Chem (2022) 236, 114328-114328. PubMed Europe PubMed DOI
Elrufaie,H.A., Mohamed,L.M., Hamd,A.Y., Bala,N.A., Elbadawi,F.A., Ghaboosh,H. and Alzain,A.A. Discovery of novel natural products as rhodesain inhibitors for human African trypanosomiasis using in silico techniques J Biomol Struct Dyn (2022) , 1-13. PubMed Europe PubMed DOI

2021

Arafet,K., Gonzalez,F.V. and Moliner,V. Elucidating the dual mode of action of dipeptidyl enoates in the inhibition of rhodesain cysteine proteases Chemistry (2021) PubMed Europe PubMed DOI
Barbosa da Silva,E., Rocha,D.A., Fortes,I.S., Yang,W., Monti,L., Siqueira-Neto,J.L., Caffrey,C.R., McKerrow,J., Andrade,S.F. and Ferreira,R.S. Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors J Med Chem (2021) 64, 13054-13071. PubMed Europe PubMed DOI I
Di Chio,C., Previti,S., De Luca,F., Allegra,A., Zappala,M. and Ettari,R. Drug combination studies of PS-1 and quercetin against rhodesain of Trypanosoma brucei rhodesiense Nat Prod Res (2021) , 1-5. PubMed Europe PubMed DOI I
Johe,P., Jaenicke,E., Neuweiler,H., Schirmeister,T., Kersten,C. and Hellmich,U.A. Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes J Biol Chem (2021) , 100565-100565. PubMed Europe PubMed DOI
Johe,P., Jung,S., Endres,E., Kersten,C., Zimmer,C., Ye,W., Sonnichsen,C., Hellmich,U.A., Sotriffer,C., Schirmeister,T. and Neuweiler,H. Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain ACS Chem Biol (2021) 16, 661-670. PubMed Europe PubMed DOI
Nakamura,Y., Hayashida,K., Delesalle,V., Qiu,Y., Omori,R., Simuunza,M., Sugimoto,C., Namangala,B. and Yamagishi,J. Genetic Diversity of African Trypanosomes in Tsetse Flies and Cattle From the Kafue Ecosystem Front Vet Sci (2021) 8, 599815-599815. PubMed Europe PubMed DOI PMC EPMC
Santos Nascimento,I.J.D., de Aquino,T.M. and da Silva-Junior,E.F. Cruzain and Rhodesain Inhibitors: Last Decade of Advances in Seeking for New Compounds Against American and African Trypanosomiases Curr Top Med Chem (2021) PubMed Europe PubMed DOI V

2020

Alvarez,V.E., Iribarren,P.A., Niemirowicz,G.T. and Cazzulo,J.J. Update on relevant trypanosome peptidases: Validated targets and future challenges Biochim Biophys Acta Proteins Proteom (2020) 1869, 140577-140577. PubMed Europe PubMed DOI
Arafet,K., Gonzalez,F.V. and Moliner,V. Quantum mechanics/molecular mechanics studies of the mechanism of cysteine proteases inhibition by dipeptidyl nitroalkenes Chemistry (2020) 26, 2002-2012. PubMed Europe PubMed DOI I
da Costa,C.H.S., Bonatto,V., Dos Santos,A.M., Lameira,J., Leitao,A. and Montanari,C.A. Evaluating QM/MM free energy surfaces for ranking cysteine protease covalent inhibitors J Chem Inf Model (2020) 60, 880-889. PubMed Europe PubMed DOI I
Di Chio,C., Previti,S., Amendola,G., Cosconati,S., Schirmeister,T., Zappala,M. and Ettari,R. Development of novel benzodiazepine-based peptidomimetics as inhibitors of rhodesain from Trypanosoma brucei rhodesiense ChemMedChem (2020) 15, 995-1001. PubMed Europe PubMed DOI I
Ettari,R., Previti,S., Di Chio,C., Maiorana,S., Allegra,A., Schirmeister,T. and Zappala,M. Drug synergism: studies of combination of RK-52 and curcumin against rhodesain of Trypanosoma brucei rhodesiense ACS Med Chem Lett (2020) 11, 806-810. PubMed Europe PubMed DOI PMC EPMC I
Klein,P., Johe,P., Wagner,A., Jung,S., Kuhlborn,J., Barthels,F., Tenzer,S., Distler,U., Waigel,W., Engels,B., Hellmich,U.A., Opatz,T. and Schirmeister,T. New cysteine protease inhibitors: electrophilic (het)arenes and unexpected prodrug identification for the Trypanosoma protease rhodesain Molecules (2020) 25 PubMed Europe PubMed DOI I
Klein,P., Barthels,F., Johe,P., Wagner,A., Tenzer,S., Distler,U., Le,T.A., Schmid,P., Engel,V., Engels,B., Hellmich,U.A., Opatz,T. and Schirmeister,T. Naphthoquinones as covalent reversible inhibitors of cysteine proteases: studies on inhibition mechanism and kineticsNaphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases: Studies on Inhibition Mechanism and Kinetics Molecules (2020) 25 PubMed Europe PubMed DOI I

2019

Cianni,L., Feldmann,C.W., Gilberg,E., Gutschow,M., Juliano,L., Leitao,A., Bajorath,J. and Montanari,C.A. Can cysteine protease cross-class inhibitors achieve selectivity? J Med Chem (2019) 62, 10497-10525. PubMed Europe PubMed DOI I
Ettari,R., Previti,S., Maiorana,S., Allegra,A., Schirmeister,T., Grasso,S. and Zappala,M. Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense Nat Prod Res (2019) 33, 3577-3581. PubMed Europe PubMed DOI I
Santos,L.H., Waldner,B.J., Fuchs,J.E., Pereira,G.A.N., Liedl,K.R., Caffarena,E.R. and Ferreira,R.S. Understanding structure-activity relationships for trypanosomal cysteine protease inhibitors by simulations and free energy calculations J Chem Inf Model (2019) 59, 137-148. PubMed Europe PubMed DOI I
Steverding,D. On the reversible and irreversible inhibition of rhodesain by curcumin Molecules (2019) 25 PubMed Europe PubMed DOI I

2018

Eyssen,L.E., Vather,P., Jackson,L., Ximba,P., Biteau,N., Baltz,T., Boulange,A., Buscher,P. and Coetzer,T.H.T. Recombinant and native TviCATL from Trypanosoma vivax: enzymatic characterisation and evaluation as a diagnostic target for animal African trypanosomosis Mol Biochem Parasitol (2018) 223, 50-54. PubMed Europe PubMed DOI
Giroud,M., Kuhn,B., Saint-Auret,S., Kuratli,C., Martin,R.E., Schuler,F., Diederich,F., Kaiser,M., Brun,R., Schirmeister,T. and Haap,W. 2 H-1,2,3-Triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design J Med Chem (2018) 61, 3370-3388. PubMed Europe PubMed DOI I
Giroud,M., Dietzel,U., Anselm,L., Banner,D., Kuglstatter,A., Benz,J., Blanc,J.B., Gaufreteau,D., Liu,H., Lin,X., Stich,A., Kuhn,B., Schuler,F., Kaiser,M., Brun,R., Schirmeister,T., Kisker,C., Diederich,F. and Haap,W. Repurposing a library of human cathepsin L ligands: identification of macrocyclic lactams as potent rhodesain and Trypanosoma brucei inhibitors J Med Chem (2018) 61, 3350-3369. PubMed Europe PubMed DOI S I
Macedo Koeller,C. and Bangs,J.D. Processing and targeting of cathepsin L (TbCatL) to the lysosome in Trypanosoma brucei Cell Microbiol (2018) , e12980-e12980. PubMed Europe PubMed DOI
Rocha,D.A., Silva,E.B., Fortes,I.S., Lopes,M.S., Ferreira,R.S. and Andrade,S.F. Synthesis and structure-activity relationship studies of cruzain and rhodesain inhibitors Eur J Med Chem (2018) 157, 1426-1459. PubMed Europe PubMed DOI I
Royo,S., Schirmeister,T., Kaiser,M., Jung,S., Rodriguez,S., Bautista,J.M. and Gonzalez,F.V. Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates Bioorg Med Chem (2018) 26, 4624-4634. PubMed Europe PubMed DOI I

2017

Ferreira,L.G. and Andricopulo,A.D. Targeting cysteine proteases in trypanosomatid disease drug discovery Pharmacol Ther (2017) 180, 49-61. PubMed Europe PubMed DOI T
Giroud,M., Ivkovic,J., Martignoni,M., Fleuti,M., Trapp,N., Haap,W., Kuglstatter,A., Benz,J., Kuhn,B., Schirmeister,T. and Diederich,F. Inhibition of the cysteine protease human cathepsin L by triazine nitriles: amide???heteroarene pi-stacking interactions and chalcogen bonding in the S3 pocket ChemMedChem (2017) 12, 257-270. PubMed Europe PubMed DOI I
Previti,S., Ettari,R., Cosconati,S., Amendola,G., Chouchene,K., Wagner,A., Hellmich,U.A., Ulrich,K., Krauth-Siegel,R.L., Wich,P.R., Schmid,I., Schirmeister,T., Gut,J., Rosenthal,P.J., Grasso,S. and Zappala,M. Development of novel peptide-based Michael acceptors targeting rhodesain and falcipain-2 for the treatment of neglected tropical diseases (NTDs) J Med Chem (2017) 60, 6911-6923. PubMed Europe PubMed DOI I
Schirmeister,T., Schmitz,J., Jung,S., Schmenger,T., Krauth-Siegel,R.L. and Gutschow,M. Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei Bioorg Med Chem Lett (2017) 27, 45-50. PubMed Europe PubMed DOI I

2016

Ettari,R., Previti,S., Cosconati,S., Kesselring,J., Schirmeister,T., Grasso,S. and Zappala,M. Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors J Enzyme Inhib Med Chem (2016) 31, 1184-1191. PubMed Europe PubMed DOI I
Ettari,R., Previti,S., Tamborini,L., Cullia,G., Grasso,S. and Zappala,M. The inhibition of cysteine proteases rhodesain and TbCatB: a valuable approach to treat human African trypanosomiasis Mini Rev Med Chem (2016) 16, 1374-1391. PubMed Europe PubMed DOI V I
Latorre,A., Schirmeister,T., Kesselring,J., Jung,S., Johe,P., Hellmich,U.A., Heilos,A., Engels,B., Krauth-Siegel,R.L., Dirdjaja,N., Bou-Iserte,L., Rodriguez,S. and Gonzalez,F.V. Dipeptidyl nitroalkenes as potent reversible inhibitors of cysteine proteases rhodesain and cruzain ACS Med Chem Lett (2016) 7, 1073-1076. PubMed Europe PubMed DOI PMC EPMC I

2015

Ettari,R., Pinto,A., Previti,S., Tamborini,L., Angelo,I.C., La Pietra,V., Marinelli,L., Novellino,E., Schirmeister,T., Zappala,M., Grasso,S., De Micheli,C. and Conti,P. Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation Bioorg Med Chem (2015) 23, 7053-7060. PubMed Europe PubMed DOI I
Fonseca,N.C., da Cruz,L.F., da Silva Villela,F., do Nascimento Pereira,G.A., de Siqueira-Neto,J.L., Kellar,D., Suzuki,B.M., Ray,D., de Souza,T.B., Alves,R.J., Junior,P.A., Romanha,A.J., Murta,S.M., McKerrow,J.H., Caffrey,C.R., de Oliveira,R.B. and Ferreira,R.S. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1 Antimicrob Agents Chemother (2015) 59, 2666-2677. PubMed Europe PubMed DOI I
McShan,D., Kathman,S., Lowe,B., Xu,Z., Zhan,J., Statsyuk,A. and Ogungbe,I.V. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain Bioorg Med Chem Lett (2015) 25, 4509-4512. PubMed Europe PubMed DOI I
Royo,S., Rodriguez,S., Schirmeister,T., Kesselring,J., Kaiser,M. and Gonzalez,F.V. Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action ChemMedChem (2015) 10, 1484-1487. PubMed Europe PubMed DOI I

2014

Alsford,S., Currier,R.B., Guerra-Assuncao,J.A., Clark,T.G. and Horn,D. Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei PLoS Pathog (2014) 10, e1004130-e1004130. PubMed Europe PubMed DOI PMC EPMC
Ettari,R., Pinto,A., Tamborini,L., Angelo,I.C., Grasso,S., Zappala,M., Capodicasa,N., Yzeiraj,L., Gruber,E., Aminake,M.N., Pradel,G., Schirmeister,T., De Micheli,C. and Conti,P. Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents ChemMedChem (2014) 9, 1817-1825. PubMed Europe PubMed DOI I

2013

Ehmke,V., Winkler,E., Banner,D.W., Haap,W., Schweizer,W.B., Rottmann,M., Kaiser,M., Freymond,C., Schirmeister,T. and Diederich,F. Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L ChemMedChem (2013) 8, 967-975. PubMed Europe PubMed DOI I
Elliott,E.B., McCarroll,D., Hasumi,H., Welsh,C.E., Panissidi,A.A., Jones,N.G., Rossor,C.L., Tait,A., Smith,G.L., Mottram,J.C., Morrison,L.J. and Loughrey,C.M. Trypanosoma brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes Cardiovasc Res (2013) 100, 325-335. PubMed Europe PubMed DOI
Ettari,R., Tamborini,L., Angelo,I.C., Grasso,S., Schirmeister,T., Lo Presti,L., De Micheli,C., Pinto,A. and Conti,P. Development of rhodesain inhibitors with a 3-bromoisoxazoline warhead ChemMedChem (2013) 8, 2070-2076. PubMed Europe PubMed DOI I
Ettari,R., Tamborini,L., Angelo,I.C., Micale,N., Pinto,A., De Micheli,C. and Conti,P. Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis J Med Chem (2013) 56, 5637-5658. PubMed Europe PubMed DOI I

2012

Costa,T.F., Reis,F.C. and Lima,A.P. Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L Biochim Biophys Acta (2012) 1824, 493-501. PubMed Europe PubMed DOI
Ehmke,V., Quinsaat,J.E., Rivera-Fuentes,P., Heindl,C., Freymond,C., Rottmann,M., Brun,R., Schirmeister,T. and Diederich,F. Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors Org Biomol Chem (2012) 10, 5764-5768. PubMed Europe PubMed DOI I
Steverding,D., Sexton,D.W., Wang,X., Gehrke,S.S., Wagner,G.K. and Caffrey,C.R. Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target Int J Parasitol (2012) 42, 481-488. PubMed Europe PubMed DOI I
Yang,P.Y., Wang,M., Li,L., Wu,H., He,C.Y. and Yao,S.Q. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents Chemistry (2012) 18, 6528-6541. PubMed Europe PubMed DOI I

2011

Caffrey,C.R., Lima,A.P. and Steverding,D. Cysteine peptidases of kinetoplastid parasites Adv Exp Med Biol (2011) 712, 84-99. PubMed Europe PubMed DOI V
Ehmke,V., Heindl,C., Rottmann,M., Freymond,C., Schweizer,W.B., Brun,R., Stich,A., Schirmeister,T. and Diederich,F. Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei ChemMedChem (2011) 6, 273-278. PubMed Europe PubMed DOI I

2010

Breuning,A., Degel,B., Schulz,F., Buchold,C., Stempka,M., Machon,U., Heppner,S., Gelhaus,C., Leippe,M., Leyh,M., Kisker,C., Rath,J., Stich,A., Gut,J., Rosenthal,P.J., Schmuck,C. and Schirmeister,T. Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids J Med Chem (2010) 53, 1951-1963. PubMed Europe PubMed DOI I
Ettari,R., Zappala,M., Micale,N., Schirmeister,T., Gelhaus,C., Leippe,M., Evers,A. and Grasso,S. Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain Eur J Med Chem (2010) 45, 3228-3233. PubMed Europe PubMed DOI I
Kerr,I.D., Wu,P., Marion-Tsukamaki,R., Mackey,Z.B. and Brinen,L.S. Crystal structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei PLoS Negl Trop Dis (2010) 4, e701-e701. PubMed Europe PubMed DOI PMC EPMC S
Mott,B.T., Ferreira,R.S., Simeonov,A., Jadhav,A., Ang,K.K., Leister,W., Shen,M., Silveira,J.T., Doyle,P.S., Arkin,M.R., McKerrow,J.H., Inglese,J., Austin,C.P., Thomas,C.J., Shoichet,B.K. and Maloney,D.J. Identification and optimization of inhibitors of trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB J Med Chem (2010) 53, 52-60. PubMed Europe PubMed DOI S I
Waag,T., Gelhaus,C., Rath,J., Stich,A., Leippe,M. and Schirmeister,T. Allicin and derivates are cysteine protease inhibitors with antiparasitic activity Bioorg Med Chem Lett (2010) 20, 5541-5543. PubMed Europe PubMed DOI I

2009

Caffrey,C.R. and Steverding,D. Kinetoplastid papain-like cysteine peptidases Mol Biochem Parasitol (2009) 167, 12-19. PubMed Europe PubMed DOI I
Cortez,A.P., Rodrigues,A.C., Garcia,H.A., Neves,L., Batista,J.S., Bengaly,Z., Paiva,F. and Teixeira,M.M. Cathepsin L-like genes of Trypanosoma vivax from Africa and South America - characterization, relationships and diagnostic implications Mol Cell Probes (2009) 23, 44-51. PubMed Europe PubMed DOI
Kerr,I.D., Lee,J.H., Farady,C.J., Marion,R., Rickert,M., Sajid,M., Pandey,K.C., Caffrey,C.R., Legac,J., Hansell,E., McKerrow,J.H., Craik,C.S., Rosenthal,P.J. and Brinen,L.S. Vinyl sulfones as antiparasitic agents and a structural basis for drug design J Biol Chem (2009) 284, 25697-25703. PubMed Europe PubMed DOI PMC EPMC S I
Steverding,D., Wang,X. and Sexton,D.W. The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei Parasitol Res (2009) 105, 1333-1338. PubMed Europe PubMed DOI

2008

Abdulla,M.H., O'Brien,T., Mackey,Z.B., Sajid,M., Grab,D.J. and McKerrow,J.H. RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model PLoS Negl Trop Dis (2008) 2, e298-e298. PubMed Europe PubMed DOI PMC EPMC
Jaishankar,P., Hansell,E., Zhao,D.M., Doyle,P.S., McKerrow,J.H. and Renslo,A.R. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes Bioorg Med Chem Lett (2008) 18, 624-628. PubMed Europe PubMed DOI I
Mallari,J.P., Shelat,A., Kosinski,A., Caffrey,C.R., Connelly,M., Zhu,F., McKerrow,J.H. and Guy,R.K. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB Bioorg Med Chem Lett (2008) 18, 2883-2885. PubMed Europe PubMed DOI PMC EPMC I

2007

Gonzalez,F.V., Izquierdo,J., Rodriguez,S., McKerrow,J.H. and Hansell,E. Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain Bioorg Med Chem Lett (2007) 17, 6697-6700. PubMed Europe PubMed DOI I
Reis,F.C., Costa,T.F., Sulea,T., Mezzetti,A., Scharfstein,J., Bromme,D., Menard,R. and Lima,A.P. The propeptide of cruzipain - a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F FEBS J (2007) 274, 1224-1234. PubMed Europe PubMed DOI

2006

[YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities J Biol Chem (6-3-2006) 281, 12824-12832. PubMed Europe PubMed DOI P
[YEAR:2-10-2006]Nikolskaia,O.V., de,A.L., Kim,Y.V., Lonsdale-Eccles,J.D., Fukuma,T., Scharfstein,J. and Grab,D.J. Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease J Clin Invest (2-10-2006) 116, 2739-2747. PubMed Europe PubMed DOI I
[YEAR:1-3-2006]Vicik,R., Hoerr,V., Glaser,M., Schultheis,M., Hansell,E., McKerrow,J.H., Holzgrabe,U., Caffrey,C.R., Ponte-Sucre,A., Moll,H., Stich,A. and Schirmeister,T. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents Bioorg Med Chem Lett (1-3-2006) 16, 2753-2757. PubMed Europe PubMed DOI I

2005

[YEAR:3-1-2005]Fujii,N., Mallari,J.P., Hansell,E.J., Mackey,Z., Doyle,P., Zhou,Y.M., Gut,J., Rosenthal,P.J., McKerrow,J.H. and Guy,R.K. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain Bioorg Med Chem Lett (3-1-2005) 15, 121-123. PubMed Europe PubMed DOI I
[YEAR:10-2-2005]Gosalia,D.N., Salisbury,C.M., Ellman,J.A. and Diamond,S.L. High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays Mol Cell Proteomics (10-2-2005) 4, 626-636. PubMed Europe PubMed DOI

2003

[YEAR:20-10-2003]Chiyanzu,I., Hansell,E., Gut,J., Rosenthal,P.J., McKerrow,J.H. and Chibale,K. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain Bioorg Med Chem Lett (20-10-2003) 13, 3527-3530. PubMed Europe PubMed DOI I

2001

Caffrey,C.R., Hansell,E., Lucas,K.D., Brinen,L.S., Hernandez,A.A., Cheng,J.N., Gwaltney,S.L., II, Roush,W.R., Stierhof,Y.D., Bogyo,M., Steverding,D. and McKerrow,J.H. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense Mol Biochem Parasitol (2001) 118, 61-73. PubMed Europe PubMed DOI

1999

Scory,S., Caffrey,C.R., Stierhof,Y.D., Ruppel,A. and Steverding,D. Trypanosoma brucei: killing of bloodstream forms in vitro and in vivo by the cysteine proteinase inhibitor Z-Phe-Ala-CHN2 Exp Parasitol (1999) 91, 327-333. PubMed Europe PubMed DOI I
Troeberg,L., Morty,R.E., Pike,R.N., Lonsdale-Eccles,J.D., Palmer,J.T., McKerrow,J.H. and Coetzer,T.H. Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei Exp Parasitol (1999) 91, 349-355. PubMed Europe PubMed DOI I

1991

Pamer,E.G., Davis,C.E. and So,M. Expression and deletion analysis of the Trypanosoma brucei rhodesiense cysteine protease in Escherichia coli Infect Immun (1991) 59, 1074-1078. PubMed Europe PubMed PMC EPMC

1990

Pamer,E.G., Davis,C.E., Eakin,A. and So,M. Cloning and sequencing of the cysteine protease cDNA from Trypanosoma brucei rhodesiense Nucleic Acids Res (1990) 18, 6141-6141. PubMed Europe PubMed PMC EPMC

1989

Mottram,J.C., North,M.J., Barry,J.D. and Coombs,G.H. A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension FEBS Lett (1989) 258, 211-215. PubMed Europe PubMed DOI