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Literature for peptidase C01.063: falcipain-3

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Hernandez Gonzalez,J.E., Salas-Sarduy,E., Alvarez,L.H., Valiente,P.A., Arni,R.K. and Pascutti,P.G.<br>Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?<br>Curr Med Chem (2024) 31, 2234-2263. PubMed  Europe PubMed DOI
  2. Madhav,H., Reddy,G.S., Rizvi,Z., Jameel,E., Patel,T.S., Rahman,A., Yadav,V., Fatima,S., Heyat,F., Pal,K., Minju-Op,A., Subbarao,N., Bhattacharjee,S., Dixit,B.C., Sijwali,P.S. and Hoda,N.<br>Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria<br>RSC Med Chem (2024) 15, 1022-1037. PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2023
  3. Patra,J., Rana,D., Arora,S., Pal,M. and Mahindroo,N.<br>Falcipains: Biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials<br>Eur J Med Chem (2023) 252, 115299-115299. PubMed  Europe PubMed DOI
    4. 2020
  4. Ettari,R., Previti,S., Di Chio,C. and Zappala,M.<br>Falcipain-2 and falcipain-3 inhibitors as promising antimalarial agents<br>Curr Med Chem (2020) PubMed  Europe PubMed DOI  V
  5. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S., Pandey,K.C. and Singh,S.<br>Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent antimalarial<br>J Biomol Struct Dyn (2020) , 1-13. PubMed  Europe PubMed DOI
  6. Rosenthal,P.J.<br>Falcipain cysteine proteases of malaria parasites: an update<br>Biochim Biophys Acta Proteins Proteom (2020) 1868, 140362-140362. PubMed  Europe PubMed DOI
    7. 2019
  7. Pasupureddy,R., Verma,S., Pant,A., Sharma,R., Seshadri,S., Pande,V., Saxena,A.K., Dixit,R. and Pandey,K.C.<br>Crucial residues in falcipains that mediate hemoglobin hydrolysis<br>Exp Parasitol (2019) 197, 43-50. PubMed  Europe PubMed DOI
  8. Rana,D., Kalamuddin,M., Sundriyal,S., Jaiswal,V., Sharma,G., Das Sarma,K., Sijwali,P.S., Mohmmed,A., Malhotra,P. and Mahindroo,N.<br>Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity<br>Bioorg Med Chem (2019) , 115155-115155. PubMed  Europe PubMed DOI  I
  9. Stoye,A., Juillard,A., Tang,A.H., Legac,J., Gut,J., White,K.L., Charman,S.A., Rosenthal,P.J., Grau,G.E.R., Hunt,N.H. and Payne,R.J.<br>Falcipain inhibitors based on the natural product gallinamide A are potent in vitro and in vivo antimalarials<br>J Med Chem (2019) 62, 5562-5578. PubMed  Europe PubMed DOI  I
    10. 2018
  10. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E.<br>Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery<br>Curr Drug Targets (2018) 19, 501-526. PubMed  Europe PubMed DOI  I
  11. Saddala,M.S. and Adi,P.J.<br>Discovery of small molecules through pharmacophore modeling, docking and molecular dynamics simulation against Plasmodium vivax vivapain-3 (VP-3)<br>Heliyon (2018) 4, e00612-e00612. PubMed  Europe PubMed DOI  PMC  EPMC  I
    12. 2016
  12. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.<br>Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs<br>Sci Rep (2016) 6, 23690-23690. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.<br>Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow<br>J Biomol Struct Dyn (2016) 34, 2084-2101. PubMed  Europe PubMed DOI  I
  14. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.<br>Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites<br>Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Poongavanam,V. and Kongsted,J.<br>Binding affinity models for falcipain inhibition based on the linear interaction energy method<br>J Mol Graph Model (2016) 70, 236-245. PubMed  Europe PubMed DOI  I
    16. 2015
  16. Kolla,V.K., Prasad,R., Sayyad,Z., Atul, Shah,A.Y., Allanki,A.D., Navale,R., Singhal,N., Tanneru,N., Sudhakar,R., Venkatesan,V., Deshmukh,M.V. and Sijwali,P.S.<br>Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates<br>Mol Biochem Parasitol (2015) 202, 11-22. PubMed  Europe PubMed DOI
    17. 2014
  17. Conroy,T., Guo,J.T., Elias,N., Cergol,K.M., Gut,J., Legac,J., Khatoon,L., Liu,Y., McGowan,S., Rosenthal,P.J., Hunt,N.H. and Payne,R.J.<br>Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials<br>J Med Chem (2014) 57, 10557-10563. PubMed  Europe PubMed DOI  I
  18. Weldon,D.J., Shah,F., Chittiboyina,A.G., Sheri,A., Chada,R.R., Gut,J., Rosenthal,P.J., Shivakumar,D., Sherman,W., Desai,P., Jung,J.C. and Avery,M.A.<br>Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of alpha-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum<br>Bioorg Med Chem Lett (2014) 24, 1274-1279. PubMed  Europe PubMed DOI  I
    19. 2013
  19. Cotrin,S.S., Gouvea,I.E., Melo,P.M., Bagnaresi,P., Assis,D.M., Araujo,M.S., Juliano,M.A., Gazarini,M.L., Rosenthal,P.J., Juliano,L. and Carmona,A.K.<br>Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity<br>Mol Biochem Parasitol (2013) 187, 111-116. PubMed  Europe PubMed DOI  P
  20. Kesharwani,R.K., Singh,D.V. and Misra,K.<br>Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: A structure-based drug designing approach<br>J Vector Borne Dis (2013) 50, 93-102. PubMed  Europe PubMed  I
  21. Mane,U.R., Gupta,R.C., Nadkarni,S.S., Giridhar,R.R., Naik,P.P. and Yadav,M.R.<br>Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review<br>Expert Opin Ther Pat (2013) 23, 165-187. PubMed  Europe PubMed DOI  V  I
  22. Rathi,B., Singh,A.K., Kishan,R., Singh,N., Latha,N., Srinivasan,S., Pandey,K.C., Tiwari,H.K. and Singh,B.K.<br>Functionalized hydroxyethylamine based peptide nanostructures as potential inhibitors of falcipain-3, an essential proteases of Plasmodium falciparum<br>Bioorg Med Chem (2013) 21, 5503-5509. PubMed  Europe PubMed DOI  I
  23. Wang,J., Li,F., Li,Y., Yang,Y., Zhang,S. and Yang,L.<br>Structural features of falcipain-3 inhibitors: an in silico study<br>Mol Biosyst (2013) 9, 2296-2310. PubMed  Europe PubMed DOI  I
    24. 2012
  24. Bagnaresi,P., de Barros,N.M., Assis,D.M., Melo,P.M., Fonseca,R.G., Juliano,M.A., Pesquero,J.B., Juliano,L., Rosenthal,P.J., Carmona,A.K. and Gazarini,M.L.<br>Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins<br>Malar J (2012) 11, 156-156. PubMed  Europe PubMed DOI
  25. Chintakrindi,A.S., Shaikh,M.S. and Coutinho,E.C.<br>De novo design of 7-aminocoumarin derivatives as novel falcipain-3 inhibitors<br>J Mol Model (2012) 18, 1481-1493. PubMed  Europe PubMed DOI  I
  26. Marco,M. and Coteron,J.M.<br>Falcipain inhibition as a promising antimalarial target<br>Curr Top Med Chem (2012) 12, 408-444. PubMed  Europe PubMed DOI  I
  27. Pandey,K.C. and Dixit,R.<br>Structure-function of falcipains: malarial cysteine proteases<br>J Trop Med (2012) 2012, 345195-345195. PubMed  Europe PubMed DOI  I
  28. Prasad,R., Atul, Soni,A., Puri,S.K. and Sijwali,P.S.<br>Expression, characterization, and cellular localization of knowpains, papain-like cysteine proteases of the Plasmodium knowlesi malaria parasite<br>PLoS ONE (2012) 7, e51619-e51619. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Shah,F., Gut,J., Legac,J., Shivakumar,D., Sherman,W., Rosenthal,P.J. and Avery,M.A.<br>Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis<br>J Chem Inf Model (2012) 52, 696-710. PubMed  Europe PubMed DOI  I
  30. Sundararaj,S., Singh,D., Saxena,A.K., Vashisht,K., Sijwali,P.S., Dixit,R. and Pandey,K.C.<br>The ionic and hydrophobic interactions are required for the auto activation of cysteine proteases of Plasmodium falciparum<br>PLoS ONE (2012) 7, e47227-e47227. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2011
  31. Pandey,K.C.<br>Centenary celebrations article: Cysteine proteases of human malaria parasites<br>J Parasitic Dis (2011) 35, 94-103. PubMed  Europe PubMed DOI
  32. Potshangbam,A.M., Tanneeru,K., Reddy,B.M. and Guruprasad,L.<br>3D-QSAR and molecular docking studies of 2-pyrimidinecarbonitrile derivatives as inhibitors against falcipain-3<br>Bioorg Med Chem Lett (2011) 21, 7219-7223. PubMed  Europe PubMed DOI  I
  33. Rosenthal,P.J.<br>Falcipains and other cysteine proteases of malaria parasites<br>Adv Exp Med Biol (2011) 712, 30-48. PubMed  Europe PubMed DOI
  34. Shah,F., Mukherjee,P., Gut,J., Legac,J., Rosenthal,P.J., Tekwani,B.L. and Avery,M.A.<br>Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library<br>J Chem Inf Model (2011) 51, 852-864. PubMed  Europe PubMed DOI  I
    35. 2010
  35. Breuning,A., Degel,B., Schulz,F., Buchold,C., Stempka,M., Machon,U., Heppner,S., Gelhaus,C., Leippe,M., Leyh,M., Kisker,C., Rath,J., Stich,A., Gut,J., Rosenthal,P.J., Schmuck,C. and Schirmeister,T.<br>Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids<br>J Med Chem (2010) 53, 1951-1963. PubMed  Europe PubMed DOI  I
  36. Coteron,J.M., Catterick,D., Castro,J., Chaparro,M.J., Diaz,B., Fernandez,E., Ferrer,S., Gamo,F.J., Gordo,M., Gut,J., de Las Heras,L., Legac,J., Marco,M., Miguel,J., Munoz,V., Porras,E., de la Rosa,J.C., Ruiz,J.R., Sandoval,E., Ventosa,P., Rosenthal,P.J. and Fiandor,J.M.<br>Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series<br>J Med Chem (2010) 53, 6129-6152. PubMed  Europe PubMed DOI  I
  37. Gibbons,P., Verissimo,E., Araujo,N.C., Barton,V., Nixon,G.L., Amewu,R.K., Chadwick,J., Stocks,P.A., Biagini,G.A., Srivastava,A., Rosenthal,P.J., Gut,J., Guedes,R.C., Moreira,R., Sharma,R., Berry,N., Cristiano,M.L., Shone,A.E., Ward,S.A. and O'Neill,P.M.<br>Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity<br>J Med Chem (2010) 53, 8202-8206. PubMed  Europe PubMed DOI  I
  38. Loser,R., Gut,J., Rosenthal,P.J., Frizler,M., Gutschow,M. and Andrews,K.T.<br>Antimalarial activity of azadipeptide nitriles<br>Bioorg Med Chem Lett (2010) 20, 252-255. PubMed  Europe PubMed DOI  I
    39. 2009
  39. Dude,M.A., Kaeppler,U., Herb,M., Schiller,M., Schulz,F., Vedder,B., Heppner,S., Pradel,G., Gut,J., Rosenthal,P.J., Schirmeister,T., Leippe,M. and Gelhaus,C.<br>Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid<br>Molecules (2009) 14, 19-35. PubMed  Europe PubMed DOI  I
  40. Kerr,I.D., Lee,J.H., Farady,C.J., Marion,R., Rickert,M., Sajid,M., Pandey,K.C., Caffrey,C.R., Legac,J., Hansell,E., McKerrow,J.H., Craik,C.S., Rosenthal,P.J. and Brinen,L.S.<br>Vinyl sulfones as antiparasitic agents and a structural basis for drug design<br>J Biol Chem (2009) 284, 25697-25703. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  41. Kerr,I.D., Lee,J.H., Pandey,K.C., Harrison,A., Sajid,M., Rosenthal,P.J. and Brinen,L.S.<br>Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity<br>J Med Chem (2009) 52, 852-857. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  42. Subramanian,S., Hardt,M., Choe,Y., Niles,R.K., Johansen,E.B., Legac,J., Gut,J., Kerr,I.D., Craik,C.S. and Rosenthal,P.J.<br>Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3<br>PLoS ONE (2009) 4, e5156-e5156. PubMed  Europe PubMed DOI  PMC  EPMC  P
    43. 2008
  43. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E.<br>Plasmodium food vacuole plasmepsins are activated by falcipains<br>J Biol Chem (2008) 283, 12870-12876. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Verissimo,E., Berry,N., Gibbons,P., Cristiano,M.L., Rosenthal,P.J., Gut,J., Ward,S.A. and O'Neill,P.M.<br>Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors<br>Bioorg Med Chem Lett (2008) 18, 4210-4214. PubMed  Europe PubMed DOI  I
    45. 2007
  45. Schulz,F., Gelhaus,C., Degel,B., Vicik,R., Heppner,S., Breuning,A., Leippe,M., Gut,J., Rosenthal,P.J. and Schirmeister,T.<br>Screening of protease inhibitors as antiplasmodial agents. Part I: aziridines and epoxides<br>ChemMedChem (2007) 2, 1214-1224. PubMed  Europe PubMed DOI  I
  46. Subramanian,S., Sijwali,P.S. and Rosenthal,P.J.<br>Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole<br>J Biol Chem (2007) 282, 24961-24969. PubMed  Europe PubMed DOI
    47. 2006
  47. [YEAR:15-6-2006]Ramjee,M.K., Flinn,N.S., Pemberton,T.P., Quibell,M., Wang,Y. and Watts,J.P.<br>Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery<br>Biochem J (15-6-2006) 399, 47-57. PubMed  Europe PubMed DOI  P
  48. [YEAR:20-7-2006]Sijwali,P.S., Koo,J., Singh,N. and Rosenthal,P.J.<br>Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum<br>Mol Biochem Parasitol (20-7-2006) 150, 96-106. PubMed  Europe PubMed DOI  K
    49. 2005
  49. Dahl,E.L. and Rosenthal,P.J.<br>Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum<br>Mol Biochem Parasitol (2005) 139, 205-212. PubMed  Europe PubMed DOI
  50. Florent,I., Lecaille,F., Montagne,J.J., Gauthier,F., Schrevel,J. and Lalmanach,G.<br>Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe<br>Biol Chem (2005) 386, 401-406. PubMed  Europe PubMed DOI
    51. 2004
  51. Desai,P.V. and Avery,M.A.<br>Structural characterization of vivapain-2 and vivapain-3, cysteine proteases from Plasmodium vivax: comparative protein modeling and docking studies<br>J Biomol Struct Dyn (2004) 21, 781-790. PubMed  Europe PubMed DOI
  52. Desai,P.V., Patny,A., Sabnis,Y., Tekwani,B., Gut,J., Rosenthal,P., Srivastava,A. and Avery,M.<br>Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database<br>J Med Chem (2004) 47, 6609-6615. PubMed  Europe PubMed DOI  I
  53. [YEAR:15-9-2004]Na,B.K., Kim,T.S., Rosenthal,P.J., Lee,J.K. and Kong,Y.<br>Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors<br>Parasitol Res (15-9-2004) 94, 312-317. PubMed  Europe PubMed DOI  I
  54. [YEAR:20-11-2004]Na,B.K., Shenai,B.R., Sijwali,P.S., Choe,Y., Pandey,K.C., Singh,A., Craik,C.S. and Rosenthal,P.J.<br>Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax<br>Biochem J (20-11-2004) 378, 529-538. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Rosenthal,P.J.<br>Falcipains<br>[ISSN:0-12-079610-4] (2004) 2, 1157-1160.  V
    56. 2003
  56. Lee,B.J., Singh,A., Chiang,P., Kemp,S.J., Goldman,E.A., Weinhouse,M.I., Vlasuk,G.P. and Rosenthal,P.J.<br>Antimalarial activities of novel synthetic cysteine protease inhibitors<br>Antimicrobial Agents Chemother (2003) 47, 3810-3814. PubMed  Europe PubMed DOI  PMC  EPMC  I
  57. Shenai,B.R., Lee,B.J., Alvarez-Hernandez,A., Chong,P.Y., Emal,C.D., Neitz,R.J., Roush,W.R. and Rosenthal,P.J.<br>Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones<br>Antimicrobial Agents Chemother (2003) 47, 154-160. PubMed  Europe PubMed DOI  PMC  EPMC  I
    58. 2001
  58. [YEAR:1-12-2001]Sijwali,P.S., Shenai,B.R., Gut,J., Singh,A. and Rosenthal,P.J.<br>Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3<br>Biochem J (1-12-2001) 360, 481-489. PubMed  Europe PubMed DOI  PMC  EPMC
    59. 1987
  59. [YEAR:1-9-1987]Rosenthal,P.J., Kim,K., McKerrow,J.H. and Leech,J.H.<br>Identification of three stage-specific proteinases of Plasmodium falciparum<br>J Exp Med (1-9-1987) 166, 816-821. PubMed  Europe PubMed  PMC  EPMC

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