$VAR1 = undef;

Summary for peptidase C01.063: falcipain-3

Names
MEROPS Name	falcipain-3
Other names	vivapain-3 (Plasmodium vivax)

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.063
Holotype	falcipain-3 (Plasmodium falciparum) (peptidase unit: 268-492), MERNUM MER0012048
History	Identifier created: MEROPS 5.8 (19 March 2002)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (77 cleavages)
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR12411:SF546
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/l/--/-/-/- (based on 126 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	8	7	4	10	7	6	10	9
Pro	9	6	3	2	4	8	7	4
Ala	10	15	4	15	25	13	7	11
Val	6	15	20	6	4	10	7	12
Leu	8	23	37	13	18	11	14	10
Ile	0	1	0	0	0	0	0	0
Met	2	4	2	0	1	1	1	1
Phe	9	5	10	6	6	7	7	4
Tyr	1	1	7	1	1	3	5	1
Trp	2	1	1	1	2	1	3	0
Ser	7	6	6	9	12	7	8	4
Thr	6	6	9	8	5	7	2	11
Cys	1	1	0	1	2	0	1	0
Asn	5	5	1	4	5	2	2	3
Gln	1	2	3	4	1	0	3	1
Asp	7	4	6	5	4	4	8	10
Glu	4	4	7	4	1	6	13	5
Lys	4	8	3	17	7	6	6	6
Arg	3	3	1	14	3	1	3	2
His	6	4	2	5	6	9	7	6

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Plasmodium falciparum	recombinant	broad	L/F	L	R/K	-	-	-	-	broad-LLR	AMC	Ramjee et al., 2006
Plasmodium falciparum	recombinant	H/N/broad	n/P/K/broad	L	R/Q/T/broad	-	-	-	-	HnLR	ACC	Subramanian et al., 2009
Plasmodium falciparum	recombinant	-	-	L	R	A	-	-	-	xxLRAxxx	Abz-Tyr(NO2)	Ramjee et al., 2006