Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C01.006: ficin

Summary Alignment Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Bruce,B.<br>Enzyme treatment of red blood cells: use of ficin and papain<br>Immunohematology (2022) 38, 90-95. PubMed  Europe PubMed DOI  V
    2. 2020
  2. Filippova,I.Y., Dvoryakova,E.A., Sokolenko,N.I., Simonyan,T.R., Tereshchenkova,V.F., Zhiganov,N.I., Dunaevsky,Y.E., Belozersky,M.A., Oppert,B. and Elpidina,E.N.<br>New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family<br>Front Mol Biosci (2020) 7, 578758-578758. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Hamed,M.B., El-Badry,M.O., Kandil,E.I., Borai,I.H. and Fahmy,A.S.<br>A contradictory action of procoagulant ficin by a fibrinolytic serine protease from Egyptian Ficus carica latex<br>Biotechnol Rep (Amst) (2020) 27, e00492-e00492. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Nishimura,K., Higashiya,K., Ueshima,N., Abe,T. and Yasukawa,K.<br>Characterization of proteases activities in Ficus carica cultivars<br>J Food Sci (2020) 85, 535-544. PubMed  Europe PubMed DOI
  5. Sattari,F., Rigi,G. and Ghaedmohammadi,S.<br>The first report on molecular cloning, functional expression, purification, and statistical optimization of Escherichia coli-derived recombinant Ficin from Iranian fig tree (Ficus carica cv.Sabz)<br>Int J Biol Macromol (2020) 165, 2126-2135. PubMed  Europe PubMed DOI
    6. 2019
  6. Milosevic,J., Jankovic,B., Prodanovic,R. and Polovic,N.<br>Comparative stability of ficin and papain in acidic conditions and the presence of ethanol<br>Amino Acids (2019) 51, 829-838. PubMed  Europe PubMed DOI
  7. Pan,Y., Pang,Y., Shi,Y., Zheng,W., Long,Y., Huang,Y. and Zheng,H.<br>One-pot synthesis of a composite consisting of the enzyme ficin and a zinc(II)-2-methylimidazole metal organic framework with enhanced peroxidase activity for colorimetric detection for glucose<br>Mikrochim Acta (2019) 186, 213-213. PubMed  Europe PubMed DOI
    8. 2018
  8. Pan,Y., Yang,Y., Pang,Y., Shi,Y., Long,Y. and Zheng,H.<br>Enhancing the peroxidase-like activity of ficin via heme binding and colorimetric detection for uric acid<br>Talanta (2018) 185, 433-438. PubMed  Europe PubMed DOI
  9. Shabani,R., Shahidi,S.A. and Rafe,A.<br>Rheological and structural properties of enzyme-induced gelation of milk proteins by ficin and Polyporus badius<br>Food Sci Nutr (2018) 6, 287-294. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Wanderley,L.F., Soares,A.M.D.S., Silva,C.R.E., Figueiredo,I.M., Ferreira,A.T.D.S., Perales,J., Mota,H.R.O., Oliveira,J.T.A. and Costa Junior,L.M.<br>A cysteine protease from the latex of Ficus benjamina has in vitro anthelmintic activity against Haemonchus contortus<br>Rev Bras Parasitol Vet (2018) 27, 473-480. PubMed  Europe PubMed DOI
    11. 2017
  11. Baidamshina,D.R., Trizna,E.Y., Holyavka,M.G., Bogachev,M.I., Artyukhov,V.G., Akhatova,F.S., Rozhina,E.V., Fakhrullin,R.F. and Kayumov,A.R.<br>Targeting microbial biofilms using ficin, a nonspecific plant protease<br>Sci Rep (2017) 7, 46068-46068. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Yang,Y., Shen,D., Long,Y., Xie,Z. and Zheng,H.<br>Intrinsic Peroxidase-like Activity of Ficin<br>Sci Rep (2017) 7, 43141-43141. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2016
  13. Raskovic,B., Lazic,J. and Polovic,N.<br>Characterisation of general proteolytic, milk clotting and antifungal activity of Ficus carica latex during fruit ripening<br>J Sci Food Agric (2016) 96, 576-582. PubMed  Europe PubMed DOI
  14. Zare,H., Moosavi-Movahedi,A.A., Salami,M., Sheibani,N., Khajeh,K. and Habibi-Rezaei,M.<br>Autolysis control and structural changes of purified ficin from Iranian fig latex with synthetic inhibitors<br>Int J Biol Macromol (2016) 84, 464-471. PubMed  Europe PubMed DOI
    15. 2015
  15. Baeyens-Volant,D., Matagne,A., El Mahyaoui,R., Wattiez,R. and Azarkan,M.<br>A novel form of ficin from Ficus carica latex: purification and characterization<br>Phytochemistry (2015) 117, 154-167. PubMed  Europe PubMed DOI
  16. Haesaerts,S., Rodriguez Buitrago,J.A., Loris,R., Baeyens-Volant,D. and Azarkan,M.<br>Crystallization and preliminary X-ray analysis of four cysteine proteases from Ficus carica latex<br>Acta Crystallogr Sect F Struct Biol Commun (2015) 71, 459-465. PubMed  Europe PubMed DOI
    17. 2013
  17. Zare,H., Moosavi-Movahedi,A.A., Salami,M., Mirzaei,M., Saboury,A.A. and Sheibani,N.<br>Purification and autolysis of the ficin isoforms from fig (Ficus carica cv. Sabz) latex<br>Phytochemistry (2013) 87, 16-22. PubMed  Europe PubMed DOI
    18. 2012
  18. Singleton,A. and Buttle,D.J.<br>Ficain<br>[ISSN:978-0-12-407743-0] (2012) 3, 1877-1879. DOI
    19. 2011
  19. Azarkan,M., Matagne,A., Wattiez,R., Bolle,L., Vandenameele,J. and Baeyens-Volant,D.<br>Selective and reversible thiol-pegylation, an effective approach for purification and characterization of five fully active ficin (iso)forms from Ficus carica latex<br>Phytochemistry (2011) 72, 1718-1731. PubMed  Europe PubMed DOI
  20. Pourmorad,F., Honary,S., Azadbakht,M., Asgarirad,H. and Golmohammadzadeh,G.<br>Separation of proteolytic components of Iran Ficus carica latex by column chromatography and electrophoresis and latex anti-corn activity<br>Intl J Pharm Sci Rev Res (2011) 7, 83-85.  U
    21. 2010
  21. Reddy,V.B. and Lerner,E.A.<br>Plant cysteine proteases that evoke itch activate protease-activated receptors<br>Br J Dermatol (2010) 163, 532-535. PubMed  Europe PubMed DOI
    22. 2009
  22. Devaraj,K.B., Kumar,P.R. and Prakash,V.<br>Characterization of acid-induced molten globule like state of ficin<br>Int J Biol Macromol (2009) 45, 248-254. PubMed  Europe PubMed DOI
    23. 2008
  23. Devaraj,K.B., Kumar,P.R. and Prakash,V.<br>Purification, characterization, and solvent-induced thermal stabilization of ficin from Ficus carica<br>J Agric Food Chem (2008) 56, 11417-11423. PubMed  Europe PubMed DOI
  24. Huang,L., Qu,H.Z., Zhang,L., Du,S.S., Yang,S., Hao,D.Y. and Wang,X.P.<br>Purification and characterization of a proteolytic enzyme from fig latex<br>Chemical Research in Chinese Universities (2008) 24, 348-352. DOI
  25. Sekizaki,H., Toyota,E., Fuchise,T., Zhou,S., Noguchi,Y. and Horita,K.<br>Application of several types of substrates to ficin-catalyzed peptide synthesis<br>Amino Acids (2008) 34, 149-153. PubMed  Europe PubMed DOI
    26. 2007
  26. Yamamoto,N., Nakayama,A., Oshima,M., Kawasaki,N. and Aiba,S.<br>Enzymatic hydrolysis of lysine diisocyanate based polyurethanes and segmented polyurethane ureas by various proteases<br>React Funct Polym (2007) 67, 1338-1345. DOI
    27. 2004
  27. Buttle,D.J.<br>Ficain<br>[ISSN:0-12-079610-4] (2004) 2, 1141-1142.  V
    28. 1995
  28. Hansler,M., Ullmann,G. and Jakubke,H.D.<br>The application of papain, ficin and clostripain in kinetically controlled peptide synthesis in frozen aqueous solutions<br>J Pept Sci (1995) 1, 283-287. PubMed  Europe PubMed DOI
    29. 1994
  29. Lopez,L.M.I., Natalucci,C.L., Priolo,N.S., Arribere,M.C. and Caffini,N.O.<br>Proteases of higher plants. II. Ficin (EC 3.4.22.3)<br>Acta Farm Bonaer (1994) 13, 123-131.
    30. 1992
  30. Patel,M., Kayani,I.S., Mellor,G.W., Sreedharan,S., Templeton,W., Thomas,E.W., Thomas,M. and Brocklehurst,K.<br>Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin<br>Biochem J (1992) 281, 553-559. PubMed  Europe PubMed  PMC  EPMC
    31. 1986
  31. Hansson,A., Veliz,G., Naquira,C., Amren,M., Arroyo,M. and Arevalo,G.<br>Preclinical and clinical studies with latex from Ficus glabrata HBK, a traditional intestinal anthelminthic in the Amazonian area<br>J Ethnopharmacol (1986) 17, 105-138. PubMed  Europe PubMed
    32. 1985
  32. [YEAR:29-1-1985]Asboth,B., Stokum,E., Khan,I.U. and Polgar,L.<br>Mechanism of action of cysteine proteinases: oxyanion binding site is not essential in the hydrolysis of specific substrates<br>Biochemistry (29-1-1985) 24, 606-609. PubMed  Europe PubMed
    33. 1984
  33. Carotti,A., Casini,G. and Hansch,C.<br>Structure-activity relationship of the ficin hydrolysis of phenyl hippurates. Comparison with papain, actinidin, and bromelain<br>J Med Chem (1984) 27, 1427-1431. PubMed  Europe PubMed  P
    34. 1983
  34. Carey,P.R., Ozaki,Y. and Storer,A.C.<br>Comparison of the substrate conformations in the active sites of papain, chymopapain, ficin and bromelain by resonance Raman spectroscopy<br>Biochem Biophys Res Commun (1983) 117, 725-731. PubMed  Europe PubMed
  35. Lynn,K.R.<br>Definition of the site of reactivity of the ancestral protease of the papain type<br>Phytochemistry (1983) 22, 2485-2487. DOI  P
    36. 1982
  36. Brocklehurst,K., Mushiri,S.M., Patel,G. and Willenbrock,F.<br>Evidence for a close similarity in the catalytic sites of papain and ficin in near-neutral media despite differences in acidic and alkaline media. Kinetics of the reactions of papain and ficin with chloroacetate<br>Biochem J (1982) 201, 101-104. PubMed  Europe PubMed  PMC  EPMC
    37. 1976
  37. Gaughran,E.R.L.<br>Ficin: history and present status<br>Q J Crude Drug Res (1976) 14, 1-21.
  38. Malthouse,J.P. and Brocklehurst,K.<br>Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-dipyridyl disulphide as a reactivity probe<br>Biochem J (1976) 159, 221-234. PubMed  Europe PubMed  PMC  EPMC
    39. 1975
  39. Shipton,M., Kierstan,M.P.J., Malthouse,J.P.G., Stuchbury,T. and Brocklehurst,K.<br>The case for assigning a value of approximately 4 to pKa(I) of the essential histidine cysteine interactive systems of papain, bromelain and ficin<br>FEBS Lett (1975) 50, 365-368. PubMed  Europe PubMed DOI
    40. 1974
  40. Anderson,C.D. and Hall,P.L.<br>Purification of ficin by affinity chromatography<br>Anal Biochem (1974) 60, 417-423. PubMed  Europe PubMed
    41. 1973
  41. Gleisner,J.M. and Liener,I.E.<br>Chemical modification of the histidine residue located at the active site of ficin<br>Biochim Biophys Acta (1973) 317, 482-491. PubMed  Europe PubMed
  42. Mamoru,S., Masanori,S. and Chiaki,M.<br>Studies on proteinases from Ficus carica var. Horaishi IV. Kininase action of ficin A, B, C and D<br>Nihon Yakurigaku Zasshi (1973) 69, 409-417. DOI  P
    43. 1970
  43. Husain,S.S. and Lowe,G.<br>The amino acid sequence around the active-site cysteine and histidine residues, and the buried cysteine residue in ficin<br>Biochem J (1970) 117, 333-340. PubMed  Europe PubMed  PMC  EPMC
    44. 1969
  44. Whitaker,J.R.<br>Papain- and ficin-catalyzed reactions. Effect of pH on activity and conformation of ficin<br>Biochemistry (1969) 8, 1896-1901. PubMed  Europe PubMed
    45. 1968
  45. Englund,P.T., King,T.P., Craig,L.C. and Walti,A.<br>Studies on ficin. I. Its isolation and characterization<br>Biochemistry (1968) 7, 163-175. PubMed  Europe PubMed
  46. Williams,D.C., Sgarbieri,V.C. and Whitaker,J.R.<br>Proteolytic activity in the genus Ficus<br>Plant Physiol (1968) 43, 1083-1088. PubMed  Europe PubMed  PMC  EPMC
    47. 1965
  47. Lowe,G. and Williams,A.<br>Direct evidence for an acylated thiol as an intermediate in papain- and ficin-catalysed hydrolyses<br>Biochem J (1965) 96, 189-193. PubMed  Europe PubMed  PMC  EPMC
    48. 1964
  48. Lowe,G. and Williams,A.<br>Direct evidence for an acylated thiol as an intermediate in papain- and ficin-catalysed hydrolyses of esters<br>Proc Chem Soc (1964) 1964, 140-141.
  49. Sgarbieri,V.C., Gupte,S.M., Kramer,D.E. and Whitaker,J.R.<br>Ficus enzymes. I. Separation of the proteolytic enzymes of Ficus carica and Ficus glabrata latices<br>J Biol Chem (1964) 239, 2170-2177. PubMed  Europe PubMed
    50. 1958
  50. Whitaker,J.R.<br>The effect of variety and maturity on the proteolytic enzyme content of figs<br>J Food Sci (1958) 23, 371-379. DOI
    51. 1957
  51. Whitaker,J.R.<br>Properties of the proteolytic enzymes of commercial ficin<br>J Food Sci (1957) 22, 483-493. DOI
    52. 1938
  52. Walti,A.<br>Crystalline ficin<br>J Am Chem Soc (1938) 60, 493-493. DOI
    53. 1930
  53. Robbins,B.H.<br>A proteolytic enzyme in ficin, the anthelmintic principle of leche de higueron<br>J Biol Chem (1930) 87, 251-257.

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use