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Literature for peptidase A01.068: necepsin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

(Topics flags: K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Long,S.R., Zhang,H.R., Wang,J.J., Liao,Z.X., Fan,Q.X., Liang,Y.Q., Gan,C.Y., Liu,R.D., Cui,J., Zhang,X., Wang,Z.Q. and Qi,X.
    Aspartic protease 2 from Trichinella spiralis excretion/secretion products hydrolyzes tight junctions of intestinal epithelial cells
    PLoS Negl Trop Dis (2025) 19, e0013805-e0013805. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Lu,Q.Q., Zhang,X.Z., Cong,P.K., Wu,J.Y., Gao,T.R., Long,S.R., Liu,R.D., Wang,Z.Q. and Cui,J.
    A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion
    PLoS Negl Trop Dis (2025) 19, e0013680-e0013680. PubMed  Europe PubMed DOI  PMC  EPMC  K
    3. 2022
  3. Sharma,L., Pipil,S., Rawat,V.S. and Sehgal,N.
    Role of cathepsins B and D in proteolysis of yolk in the catfish Clarias gariepinus
    Fish Physiol Biochem (2022) 48, 749-765. PubMed  Europe PubMed DOI
    4. 2021
  4. Adegnika,A.A., de Vries,S.G., Zinsou,F.J., Honkepehedji,Y.J., Dejon Agobe,J.C., Vodonou,K.G., Bikangui,R., Bouyoukou Hounkpatin,A., Bache,E.B., Massinga Loembe,M., van Leeuwen,R., Molemans,M., Kremsner,P.G., Yazdanbakhsh,M., Hotez,P.J., Bottazzi,M.E., Li,G., Bethony,J.M., Diemert,D.J. and Grobusch,M.P.
    Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial
    Lancet Infect Dis (2021) 21, 275-285. PubMed  Europe PubMed DOI
  5. Huang,L., Wu,B.L., He,J.X., Zhang,Y., Chen,J. and Chen,X.J.
    Molecular characterization and functional analysis of the lysosomal cathepsin D-like gene in red swamp crayfish, Procambarus clarkii
    Genome (2021) , 1-11. PubMed  Europe PubMed DOI
    6. 2015
  6. Fuaad,A.A., Pearson,M.S., Pickering,D.A., Becker,L., Zhao,G., Loukas,A.C., Skwarczynski,M. and Toth,I.
    Lipopeptide nanoparticles: development of vaccines against hookworm parasite
    ChemMedChem (2015) 10, 1647-1654. PubMed  Europe PubMed DOI
  7. Pearson,M.S., Jariwala,A.R., Abbenante,G., Plieskatt,J., Wilson,D., Bottazzi,M.E., Hotez,P.J., Keegan,B., Bethony,J.M. and Loukas,A.
    New tools for NTD vaccines: a case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74
    Hum Vaccin Immunother (2015) 11, 1251-1257. PubMed  Europe PubMed DOI
  8. Seid,C.A., Curti,E., Jones,R.M., Hudspeth,E., Rezende,W., Pollet,J., Center,L., Versteeg,L., Pritchard,S., Musiychuk,K., Yusibov,V., Hotez,P.J. and Bottazzi,M.E.
    Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine
    Hum Vaccin Immunother (2015) 11, 1474-1488. PubMed  Europe PubMed DOI
    9. 2013
  9. Wasyl,K., Zawistowska-Deniziak,A., Baska,P., Wedrychowicz,H. and Wisniewski,M.
    Molecular cloning and expression of the cDNA sequence encoding a novel aspartic protease from Uncinaria stenocephala
    Exp Parasitol (2013) 134, 220-227. PubMed  Europe PubMed DOI
    10. 2012
  10. Dougall,A.M., Pearson,M.S. and Loukas,A.
    Na-APR-1 (aka Necepsin-2)
    [ISSN:978-0-12-407744-7] (2012) 3, 113-118. DOI
  11. Ni,F., Xu,S.S., Zhang,S.L., Xu,C.M. and Luo,D.M.
    [Cloning and expression of D-like aspartic protease of Anisakis simplex]
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2012) 30, 294-298. PubMed  Europe PubMed
  12. Park,J.N., Park,S.K., Cho,M.K., Park,M.K., Kang,S.A., Kim,D.H. and Yu,H.S.
    Molecular characterization of 45kDa aspartic protease of Trichinella spiralis
    Vet Parasitol (2012) 190, 510-518. PubMed  Europe PubMed DOI
    13. 2010
  13. Pearson,M.S., Pickering,D.A., Tribolet,L., Cooper,L., Mulvenna,J., Oliveira,L.M., Bethony,J.M., Hotez,P.J. and Loukas,A.
    Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis
    J Infect Dis (2010) 201, 1561-1569. PubMed  Europe PubMed DOI
    14. 2009
  14. Fragoso,R.R., Lourenco,I.T., Batista,J.A., Oliveira-Neto,O.B., Silva,M.C., Rocha,T.L., Coutinho,M.V. and Grossi-de-Sa,M.F.
    Meloidogyne incognita: molecular cloning and characterization of a cDNA encoding a cathepsin D-like aspartic proteinase
    Exp Parasitol (2009) 121, 115-123. PubMed  Europe PubMed DOI
  15. Ranjit,N., Zhan,B., Hamilton,B., Stenzel,D., Lowther,J., Pearson,M., Gorman,J., Hotez,P. and Loukas,A.
    Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus
    J Infect Dis (2009) 199, 904-912. PubMed  Europe PubMed DOI
  16. Yang,Y., Wei,H., Qin,W. and Zheng,J.
    Expression and characterization of aspartic protease gene in eggs and larvae stage of Ancylostoma caninum
    Parasitol Res (2009) 104, 1327-1333. PubMed  Europe PubMed DOI
    17. 2005
  17. Loukas,A., Bethony,J.M., Mendez,S., Fujiwara,R.T., Goud,G.N., Ranjit,N., Zhan,B., Jones,K., Bottazzi,M.E. and Hotez,P.J.
    Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs
    PLoS Medicine (2005) 2, e295-e295. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2004
  18. Goud,G.N., Zhan,B., Ghosh,K., Loukas,A., Hawdon,J., Dobardzic,A., Deumic,V., Liu,S., Dobardzic,R., Zook,B.C., Jin,Q., Liu,Y., Hoffman,L., Chung-Debose,S., Patel,R., Mendez,S. and Hotez,P.J.
    Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum
    J Infect Dis (2004) 189, 919-929. PubMed  Europe PubMed DOI
  19. Jolodar,A., Fischer,P., Buttner,D.W., Miller,D.J., Schmetz,C. and Brattig,N.W.
    Onchocerca volvulus: expression and immunolocalization of a nematode cathepsin D-like lysosomal aspartic protease
    Exp Parasitol (2004) 107, 145-156. PubMed  Europe PubMed DOI
    20. 2003
  20. [YEAR:1-2-2003]Williamson,A.L., Brindley,P.J., Abbenante,G., Datu,B.J., Prociv,P., Berry,C., Girdwood,K., Pritchard,D.I., Fairlie,D.P., Hotez,P.J., Zhan,B. and Loukas,A.
    Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion
    J Infect Dis (1-2-2003) 187, 484-494. PubMed  Europe PubMed DOI
  21. Williamson,A.L., Brindley,P.J. and Loukas,A.
    Hookworm cathepsin D aspartic proteases: contributing roles in the host-specific degradation of serum proteins and skin macromolecules
    Parasitology (2003) 126, 179-185. PubMed  Europe PubMed DOI
    22. 2002
  22. [YEAR:31-10-2002]Syntichaki,P., Xu,K., Driscoll,M. and Tavernarakis,N.
    Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans
    Nature (31-10-2002) 419, 939-944. PubMed  Europe PubMed DOI
  23. Williamson,A.L., Brindley,P.J., Abbenante,G., Prociv,P., Berry,C., Girdwood,K., Pritchard,D.I., Fairlie,D.P., Hotez,P.J., Dalton,J.P. and Loukas,A.
    Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity
    FASEB J (2002) 16, 1458-1460. PubMed  Europe PubMed DOI
    24. 2000
  24. [YEAR:25-8-2000]Tcherepanova,I., Bhattacharyya,L., Rubin,C.S. and Freedman,J.H.
    Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1
    J Biol Chem (25-8-2000) 275, 26359-26369. PubMed  Europe PubMed DOI
    25. 1999
  25. Brown,A., Girod,N., Billett,E.E. and Pritchard,D.I.
    Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration
    Am J Trop Med Hyg (1999) 60, 840-847. PubMed  Europe PubMed
  26. Geier,G., Banaj,H.J., Heid,H., Bini,L., Pallini,V. and Zwilling,R.
    Aspartyl proteases in Caenorhabditis elegans. Isolation, identification and characterization by a combined use of affinity chromatography, two-dimensional gel electrophoresis, microsequencing and databank analysis
    Eur J Biochem (1999) 264, 872-879. PubMed  Europe PubMed DOI
    27. 1998
  27. [YEAR:15-1-1998]Jolodar,A. and Miller,D.J.
    Identification of a novel family of non-lysosomal aspartic proteases in nematodes
    Biochim Biophys Acta (15-1-1998) 1382, 13-16. PubMed  Europe PubMed DOI
    28. 1997
  28. Jolodar,A. and Miller,D.J.
    Preliminary characterisation of an Onchocerca volvulus aspartic protease
    Int J Parasitol (1997) 27, 1087-1090. PubMed  Europe PubMed DOI
    29. 1996
  29. Harrop,S.A., Prociv,P. and Brindley,P.J.
    Acasp, a gene encoding a cathepsin D-like aspartic protease from the hookworm Ancylostoma caninum
    Biochem Biophys Res Commun (1996) 227, 294-302. PubMed  Europe PubMed DOI
    30. 1995
  30. Sato,K., Nagai,Y. and Suzuki,M.
    Purification and characterization of an acid proteinase from Dirofilaria immitis worms
    Adv Exp Med Biol (1995) 362, 299-304. PubMed  Europe PubMed
  31. Sato,K., Yamaguchi,H., Waki,S., Suzuki,M. and Nagai,Y.
    Dirofilaria immitis: immunohistochemical localization of acid proteinase in the adult worm
    Exp Parasitol (1995) 81, 63-71. PubMed  Europe PubMed DOI
    32. 1993
  32. Sato,K., Nagai,Y. and Suzuki,M.
    Purification and partial characterization of an acid proteinase from Dirofilaria immitis
    Mol Biochem Parasitol (1993) 58, 293-299. PubMed  Europe PubMed DOI

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