Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase A01.061: candidapepsin SAP3

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2015
  1. Kozik,A., Gogol,M., Bochenska,O., Karkowska-Kuleta,J., Wolak,N., Kamysz,W., Aoki,W., Ueda,M., Faussner,A. and Rapala-Kozik,M.
    Kinin release from human kininogen by 10 aspartic proteases produced by pathogenic yeast Candida albicans
    BMC Microbiol15, 60-60. PubMed  Europe PubMed DOI
    2. 2013
  2. Cadicamo,C.D., Mortier,J., Wolber,G., Hell,M., Heinrich,I.E., Michel,D., Semlin,L., Berger,U., Korting,H.C., Holtje,H.D., Koksch,B. and Borelli,C.
    Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans
    Biochem Pharmacol85, 881-887. PubMed  Europe PubMed DOI  I
    3. 2012
  3. Monod,M., Staib,P. and Borelli,C.
    Candidapepsin
    [ISSN:978-0-12-407744-7]3, 159-166. DOI
    4. 2011
  4. Aoki,W., Kitahara,N., Miura,N., Morisaka,H., Yamamoto,Y., Kuroda,K. and Ueda,M.
    Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans
    J Biochem150, 431-438. PubMed  Europe PubMed DOI  P
  5. Buchold,C., Hemberger,Y., Heindl,C., Welker,A., Degel,B., Pfeuffer,T., Staib,P., Schneider,S., Rosenthal,P.J., Gut,J., Morschhauser,J., Bringmann,G. and Schirmeister,T.
    New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors
    ChemMedChem6, 141-152. PubMed  Europe PubMed DOI  I
    6. 2010
  6. Correia,A., Lermann,U., Teixeira,L., Cerca,F., Botelho,S., Gil Da Costa,R.M., Sampaio,P., Gartner,F., Morschhauser,J., Vilanova,M. and Pais,C.
    Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis
    Infect Immun78, 4839-4849. PubMed  Europe PubMed DOI
  7. Pietrella,D., Rachini,A., Pandey,N., Schild,L., Netea,M., Bistoni,F., Hube,B. and Vecchiarelli,A.
    The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity
    Infect Immun78, 4754-4762. PubMed  Europe PubMed DOI
    8. 2009
  8. Gropp,K., Schild,L., Schindler,S., Hube,B., Zipfel,P.F. and Skerka,C.
    The yeast Candida albicans evades human complement attack by secretion of aspartic proteases
    Mol Immunol47, 465-475. PubMed  Europe PubMed DOI
  9. Parra-Ortega,B., Cruz-Torres,H., Villa-Tanaca,L. and Hernandez-Rodriguez,C.
    Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species
    Mem Inst Oswaldo Cruz104, 505-512. PubMed  Europe PubMed
    10. 2008
  10. Lermann,U. and Morschhauser,J.
    Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans
    Microbiology (Reading)154, 3281-3295. PubMed  Europe PubMed DOI
  11. Naglik,J.R., Moyes,D., Makwana,J., Kanzaria,P., Tsichlaki,E., Weindl,G., Tappuni,A.R., Rodgers,C.A., Woodman,A.J., Challacombe,S.J., Schaller,M. and Hube,B.
    Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis
    Microbiology (Reading)154, 3266-3280. PubMed  Europe PubMed DOI
  12. Odds,F.C.
    Secreted proteinases and Candida albicans virulence
    Microbiology (Reading)154, 3245-3246. PubMed  Europe PubMed DOI
  13. Staib,P., Lermann,U., Blass-Warmuth,J., Degel,B., Wurzner,R., Monod,M., Schirmeister,T. and Morschhauser,J.
    Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening
    Antimicrob Agents Chemother52, 146-156. PubMed  Europe PubMed DOI
    14. 2007
  14. Borelli,C., Ruge,E., Schaller,M., Monod,M., Korting,H.C., Huber,R. and Maskos,K.
    The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A
    Proteins68, 738-748. PubMed  Europe PubMed DOI  S  I
    15. 2003
  15. Korting,H.C., Hube,B., Oberbauer,S., Januschke,E., Hamm,G., Albrecht,A., Borelli,C. and Schaller,M.
    Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium
    J Med Microbiol52, 623-632. PubMed  Europe PubMed DOI
    16. 2002
  16. Felk,A., Kretschmar,M., Albrecht,A., Schaller,M., Beinhauer,S., Nichterlein,T., Sanglard,D., Korting,H.C., Schafer,W. and Hube,B.
    Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs
    Infect Immun70, 3689-3700. PubMed  Europe PubMed DOI
  17. Kretschmar,M., Felk,A., Staib,P., Schaller,M., Hess,D., Callapina,M., Morschhauser,J., Schafer,W., Korting,H.C., Hof,H., Hube,B. and Nichterlein,T.
    Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice
    Microb Pathog32, 61-70. PubMed  Europe PubMed DOI
    18. 2001
  18. De Bernardis,F., Sullivan,P.A. and Cassone,A.
    Aspartyl proteinases of Candida albicans and their role in pathogenicity
    Med Mycol39, 303-313. PubMed  Europe PubMed
  19. Schaller,M., Januschke,E., Schackert,C., Woerle,B. and Korting,H.C.
    Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo
    J Med Microbiol50, 743-747. PubMed  Europe PubMed
    20. 2000
  20. [YEAR:14-7-2000]Koelsch,G., Tang,J., Loy,J.A., Monod,M., Jackson,K., Foundling,S.I. and Lin,X.L.
    Enzymic characteristics of secreted aspartic proteases of Candida albicans
    Biochim Biophys Acta1480, 117-131. PubMed  Europe PubMed DOI
  21. Schaller,M., Schackert,C., Korting,H.C., Januschke,E. and Hube,B.
    Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis
    J Invest Dermatol114, 712-717. PubMed  Europe PubMed DOI
  22. Stehr,F., Felk,A., Kretschmar,M., Schaller,M., Schafer,W. and Hube,B.
    [Extracellular hydrolytic enzymes and their relevance during Candida albicans infections]
    Mycoses43 Suppl 2, 17-21. PubMed  Europe PubMed
    23. 1999
  23. Borg-von Zepelin,M., Meyer,I., Thomssen,R., Wurzner,R., Sanglard,D., Telenti,A. and Monod,M.
    HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases
    J Invest Dermatol113, 747-751. PubMed  Europe PubMed DOI  I
  24. Kretschmar,M., Hube,B., Bertsch,T., Sanglard,D., Merker,R., Schroder,M., Hof,H. and Nichterlein,T.
    Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis
    Infect Immun67, 6637-6642. PubMed  Europe PubMed
  25. Monod,M., Borg-von Zepelin,M., Telenti,A. and Sanglard,D.
    The inhibition of Candida-albicans-secreted aspartic proteases by three different HIV protease inhibitors
    Dermatology198, 412-414. PubMed  Europe PubMed  I
  26. Schaller,M., Korting,H.C., Schafer,W., Bastert,J., Chen,W. and Hube,B.
    Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis
    Mol Microbiol34, 169-180. PubMed  Europe PubMed DOI
    27. 1997
  27. Hube,B., Sanglard,D., Odds,F.C., Hess,D., Monod,M., Schafer,W., Brown,A.J. and Gow,N.A.
    Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence
    Infect Immun65, 3529-3538. PubMed  Europe PubMed
  28. Smolenski,G., Sullivan,P.A., Cutfield,S.M. and Cutfield,J.F.
    Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes
    Microbiology (Reading, Engl )143, 349-356. PubMed  Europe PubMed
    29. 1994
  29. Hube,B., Monod,M., Schofield,D.A., Brown,A.J. and Gow,N.A.
    Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans
    Mol Microbiol14, 87-99. PubMed  Europe PubMed DOI
  30. Monod,M., Togni,G., Hube,B. and Sanglard,D.
    Multiplicity of genes encoding secreted aspartic proteinases in Candida species
    Mol Microbiol13, 357-368. PubMed  Europe PubMed DOI
    31. 1993
  31. White,T.C., Miyasaki,S.H. and Agabian,N.
    Three distinct secreted aspartyl proteinases in Candida albicans
    J Bacteriol175, 6126-6133. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use