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Literature for peptidase A01.041: BACE2 g.p. (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Guan,D., Sun,S., Song,L., Zhao,P., Nie,Y., Huang,X., Zhou,W., Yan,L., Lei,Y., Hu,Y. and Wei,F.
    Taking a color photo: A homozygous 25-bp deletion in Bace2 may cause brown-and-white coat color in giant pandas
    Proc Natl Acad Sci U S A121, e2317430121-e2317430121. PubMed  Europe PubMed DOI
  2. Schmidt,A., Hrupka,B., van Bebber,F., Sunil Kumar,S., Feng,X., Tschirner,S.K., Assfalg,M., Muller,S.A., Hilger,L.S., Hofmann,L.I., Pigoni,M., Jocher,G., Voytyuk,I., Self,E.L., Ito,M., Hyakkoku,K., Yoshimura,A., Horiguchi,N., Feederle,R., De Strooper,B., Schulte-Merker,S., Lammert,E., Moechars,D., Schmid,B. and Lichtenthaler,S.F.
    The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling
    J Clin Invest134, e170550-e170550. PubMed  Europe PubMed DOI
    3. 2023
  3. He,T., d'Uscio,L.V. and Katusic,Z.S.
    BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells
    J Neurochem166, 928-942. PubMed  Europe PubMed DOI
  4. Saez-Valero,J. and Perez-Gonzalez,R.
    BACE2 beyond beta-processing of APP, its neuroprotective role in cerebrovascular endothelium
    J Neurochem166, 887-890. PubMed  Europe PubMed DOI
    5. 2021
  5. Fujimoto,K., Yoshida,S., Tadano,G., Asada,N., Fuchino,K., Suzuki,S., Matsuoka,E., Yamamoto,T., Yamamoto,S., Ando,S., Kanegawa,N., Tonomura,Y., Ito,H., Moechars,D., Rombouts,F.J.R., Gijsen,H.J.M. and Kusakabe,K.I.
    Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective beta-Secretase (BACE1) Inhibitors over BACE2
    J Med Chem64, 3075-3085. PubMed  Europe PubMed DOI  I
  6. Yen,Y.C., Kammeyer,A.M., Tirlangi,J., Ghosh,A.K. and Mesecar,A.D.
    A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors
    ACS Chem Neurosci12, 581-588. PubMed  Europe PubMed DOI
    7. 2019
  7. Ghosh,A.K., Brindisi,M., Yen,Y.C., Lendy,E.K., Kovela,S., Cardenas,E.L., Reddy,B.S., Rao,K.V., Downs,D., Huang,X., Tang,J. and Mesecar,A.D.
    Highly selective and potent human beta-secretase 2 (BACE2) inhibitors against type 2 diabetes: design, synthesis, X-ray structure and structure-activity relationship studies
    ChemMedChem14, 545-560. PubMed  Europe PubMed DOI  S  I
  8. Wang,Z., Xu,Q., Cai,F., Liu,X., Wu,Y. and Song,W.
    BACE2, a conditional beta-secretase, contributes to Alzheimer's disease pathogenesis
    JCI Insight4, PubMed  Europe PubMed DOI
    9. 2018
  9. Johansson,P., Kaspersson,K., Gurrell,I.K., Back,E., Eketjall,S., Scott,C.W., Cebers,G., Thorne,P., McKenzie,M.J., Beaton,H., Davey,P., Kolmodin,K., Holenz,J., Duggan,M.E., Budd Haeberlein,S. and Burli,R.W.
    Toward beta-secretase-1 inhibitors with improved isoform selectivity
    J Med Chem61, 3491-3502. PubMed  Europe PubMed DOI  I
  10. Liu,F., Zhang,Y., Liang,Z., Sun,Q., Liu,H., Zhao,J., Xu,J., Zheng,J., Yun,Y., Yu,X., Song,W. and Sun,X.
    Cleavage of potassium channel Kv2.1 by BACE2 reduces neuronal apoptosis
    Mol Psychiatry23, 1542-1554. PubMed  Europe PubMed DOI
    11. 2017
  11. Alcarraz-Vizan,G., Castano,C., Visa,M., Montane,J., Servitja,J.M. and Novials,A.
    BACE2 suppression promotes beta-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression
    Cell Mol Life Sci74, 2827-2838. PubMed  Europe PubMed DOI
  12. Yan,R.
    Physiological functions of the beta-site amyloid precursor protein cleaving enzyme 1 and 2
    Front Mol Neurosci10, 97-97. PubMed  Europe PubMed DOI
    13. 2016
  13. Ghosh,A.K., Reddy,B.S., Yen,Y.C., Cardenas,E., Rao,K.V., Downs,D., Huang,X., Tang,J. and Mesecar,A.D.
    Design of potent and highly selective inhibitors for human beta-secretase 2 (memapsin 1), a target for type 2 diabetes
    Chem Sci7, 3117-3122. PubMed  Europe PubMed DOI  I
  14. Kumalo,H.M. and Soliman,M.E.
    A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility
    J Recept Signal Transduct Res36, 505-514. PubMed  Europe PubMed DOI
  15. Rulifson,I.C., Cao,P., Miao,L., Kopecky,D., Huang,L., White,R.D., Samayoa,K., Gardner,J., Wu,X., Chen,K., Tsuruda,T., Homann,O., Baribault,H., Yamane,H., Carlson,T., Wiltzius,J. and Li,Y.
    Identification of human islet amyloid polypeptide as a BACE2 substrate
    PLoS ONE11, e0147254-e0147254. PubMed  Europe PubMed DOI  U
  16. Shimshek,D.R., Jacobson,L.H., Kolly,C., Zamurovic,N., Balavenkatraman,K.K., Morawiec,L., Kreutzer,R., Schelle,J., Jucker,M., Bertschi,B., Theil,D., Heier,A., Bigot,K., Beltz,K., Machauer,R., Brzak,I., Perrot,L. and Neumann,U.
    Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice
    Sci Rep6, 21917-21917. PubMed  Europe PubMed DOI  I
    17. 2015
  17. Alcarraz-Vizan,G., Casini,P., Cadavez,L., Visa,M., Montane,J., Servitja,J.M. and Novials,A.
    Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic beta-cells
    FASEB J29, 95-104. PubMed  Europe PubMed DOI
  18. Vila-Real,H., Coelho,H., Rocha,J., Fernandes,A., Ventura,M.R., Maycock,C.D., Iranzo,O. and Simplicio,A.L.
    Peptidomimetic beta-secretase inhibitors comprising a sequence of amyloid-beta peptide for Alzheimer's disease
    J Med Chem58, 5408-5418. PubMed  Europe PubMed DOI  I
    19. 2014
  19. Mirsafian,H., Mat Ripen,A., Merican,A.F. and Mohamad,S.B.
    Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method
    ScientificWorldJournal2014, 482463-482463. PubMed  Europe PubMed DOI
  20. Vassar,R., Kuhn,P.H., Haass,C., Kennedy,M.E., Rajendran,L., Wong,P.C. and Lichtenthaler,S.F.
    Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
    J Neurochem130, 4-28. PubMed  Europe PubMed DOI  K
    21. 2013
  21. Banner,D.W., Gsell,B., Benz,J., Bertschinger,J., Burger,D., Brack,S., Cuppuleri,S., Debulpaep,M., Gast,A., Grabulovski,D., Hennig,M., Hilpert,H., Huber,W., Kuglstatter,A., Kusznir,E., Laeremans,T., Matile,H., Miscenic,C., Rufer,A.C., Schlatter,D., Steyaert,J., Stihle,M., Thoma,R., Weber,M. and Ruf,A.
    Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones
    Acta Crystallogr D Biol Crystallogr69, 1124-1137. PubMed  Europe PubMed DOI  S
  22. Rosse,G.
    Dihydrooxazines as inhibitors of BACE-1 or BACE-2
    ACS Med Chem Lett4, 433-434. PubMed  Europe PubMed DOI  I
  23. Southan,C.
    BACE2 as a new diabetes target: a patent review (2010 - 2012)
    Expert Opin Ther Pat23, 649-663. PubMed  Europe PubMed DOI  I
  24. Southan,C. and Hancock,J.M.
    A tale of two drug targets: the evolutionary history of BACE1 and BACE2
    Front Genet4, 293-293. PubMed  Europe PubMed DOI
  25. Stutzer,I., Selevsek,N., Esterhazy,D., Schmidt,A., Aebersold,R. and Stoffel,M.
    Systematic proteomic analysis identifies beta-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic beta-cells
    J Biol Chem288, 10536-10547. PubMed  Europe PubMed DOI  P
    26. 2012
  26. Abdul-Hay,S.O., Sahara,T., McBride,M., Kang,D. and Leissring,M.A.
    Identification of BACE2 as an avid beta-amyloid degrading protease
    Mol Neurodegener7, 46-46. PubMed  Europe PubMed DOI
  27. Tang,J. and Koelsch,G.
    Memapsin 1
    [ISSN:978-0-12-407744-7]3, 85-87. DOI
    28. 2011
  28. Esterhazy,D., Stutzer,I., Wang,H., Rechsteiner,M.P., Beauchamp,J., Dobeli,H., Hilpert,H., Matile,H., Prummer,M., Schmidt,A., Lieske,N., Boehm,B., Marselli,L., Bosco,D., Kerr-Conte,J., Aebersold,R., Spinas,G.A., Moch,H., Migliorini,C. and Stoffel,M.
    Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass
    Cell Metab14, 365-377. PubMed  Europe PubMed DOI  K  T  I
    29. 2010
  29. Azkona,G., Levannon,D., Groner,Y. and Dierssen,M.
    In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model
    Amino Acids39, 1571-1580. PubMed  Europe PubMed DOI
  30. Casas,S., Casini,P., Piquer,S., Altirriba,J., Soty,M., Cadavez,L., Gomis,R. and Novials,A.
    BACE2 plays a role in the insulin receptor trafficking in pancreatic beta-cells
    Am J Physiol Endocrinol Metab299, E1087-E1095. PubMed  Europe PubMed DOI
    31. 2009
  31. Emmons,T.L., Mildner,A.M., Lull,J.M., Leone,J.W., Fischer,H.D., Heinrikson,R.L. and Tomasselli,A.G.
    Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli
    Protein Pept Lett16, 121-131. PubMed  Europe PubMed DOI  E
    32. 2008
  32. Finzi,G., Franzi,F., Placidi,C., Acquati,F., Palumbo,E., Russo,A., Taramelli,R., Sessa,F. and La Rosa,S.
    BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells
    Ultrastruct Pathol32, 246-251. PubMed  Europe PubMed DOI
    33. 2006
  33. [YEAR:8-11-2006]Ostermann,N., Eder,J., Eidhoff,U., Zink,F., Hassiepen,U., Worpenberg,S., Maibaum,J., Simic,O., Hommel,U. and Gerhartz,B.
    Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor
    J Mol Biol355, 249-261. PubMed  Europe PubMed DOI  S  I
  34. Sun,X., He,G. and Song,W.
    BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome
    FASEB J20, 1369-1376. PubMed  Europe PubMed DOI
    35. 2004
  35. Chou,K.C.
    Insights from modeling the tertiary structure of human BACE2
    J Proteome Res3, 1069-1072. PubMed  Europe PubMed DOI
  36. Tang,J. and Koelsch,G.
    Memapsin 1
    [ISSN:0-12-079610-4]2, 64-66.  V
  37. Vassar,R.
    BACE1: the beta-secretase enzyme in Alzheimer's disease
    J Mol Neurosci23, 105-114. PubMed  Europe PubMed DOI  K
    38. 2003
  38. [YEAR:11-7-2003]Andrau,D., Dumanchin-Njock,C., Ayral,E., Vizzavona,J., Farzan,M., Boisbrun,M., Fulcrand,P., Hernandez,J.F., Martinez,J., Lefranc-Jullien,S. and Checler,F.
    BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors
    J Biol Chem278, 25859-25866. PubMed  Europe PubMed DOI  A
  39. Barbiero,L., Benussi,L., Ghidoni,R., Alberici,A., Russo,C., Schettini,G., Pagano,S.F., Parati,E.A., Mazzoli,F., Nicosia,F., Signorini,S., Feudatari,E. and Binetti,G.
    BACE-2 is overexpressed in Down's syndrome
    Exp Neurol182, 335-345. PubMed  Europe PubMed DOI
  40. Basi,G., Frigon,N., Barbour,R., Doan,T., Gordon,G., McConlogue,L., Sinha,S. and Zeller,M.
    Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells
    J Biol Chem278, 31512-31520. PubMed  Europe PubMed DOI
  41. Vattemi,G., Engel,W.K., McFerrin,J., Pastorino,L., Buxbaum,J.D. and Askanas,V.
    BACE1 and BACE2 in pathologic and normal human muscle
    Exp Neurol179, 150-158. PubMed  Europe PubMed DOI
    42. 2002
  42. Fluhrer,R., Capell,A., Westmeyer,G., Willem,M., Hartung,B., Condron,M.M., Teplow,D.B., Haass,C. and Walter,J.
    A non-amyloidogenic function of BACE-2 in the secretory pathway
    J Neurochem81, 1011-1020. PubMed  Europe PubMed DOI
  43. Kim,Y.T., Downs,D., Wu,S., Dashti,A., Pan,Y., Zhai,P., Wang,X., Zhang,X.C. and Lin,X.
    Enzymic properties of recombinant BACE2
    Eur J Biochem269, 5668-5677. PubMed  Europe PubMed DOI
  44. [YEAR:9-7-2002]Turner,R.T., III, Loy,J.A., Nguyen,C., Devasamudram,T., Ghosh,A.K., Koelsch,G. and Tang,J.
    Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity
    Biochemistry41, 8742-8746. PubMed  Europe PubMed DOI  P  I
    45. 2001
  45. [YEAR:29-6-2001]Hussain,I., Christie,G., Schneider,K., Moore,S. and Dingwall,C.
    Prodomain processing of Asp1 (BACE2) is autocatalytic
    J Biol Chem276, 23322-23328. PubMed  Europe PubMed DOI
  46. [YEAR:3-7-2001]Nowotny,P., Kwon,J.M., Chakraverty,S., Nowotny,V., Morris,J.C. and Goate,A.M.
    Association studies using novel polymorphisms in BACE1 and BACE2
    Neuroreport12, 1799-1802. PubMed  Europe PubMed  M
    47. 2000
  47. [YEAR:18-2-2000]Acquati,F., Accarino,M., Nucci,C., Fumagalli,P., Jovine,L., Ottolenghi,S. and Taramelli,R.
    The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region
    FEBS Lett468, 59-64. PubMed  Europe PubMed DOI
  48. [YEAR:7-7-2000]Bennett,B.D., Babu-Khan,S., Loeloff,R., Louis,J.C., Curran,E., Citron,M. and Vassar,R.
    Expression analysis of BACE2 in brain and peripheral tissues
    J Biol Chem275, 20647-20651. PubMed  Europe PubMed DOI
  49. [YEAR:15-8-2000]Farzan,M., Schnitzler,C.E., Vasilieva,N., Leung,D. and Choe,H.
    BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
    Proc Natl Acad Sci U S A97, 9712-9717. PubMed  Europe PubMed DOI
  50. Hussain,I., Powell,D.J., Howlett,D.R., Chapman,G.A., Gilmour,L., Murdock,P.R., Tew,D.G., Meek,T.D., Chapman,C., Schneider,K., Ratcliffe,S.J., Tattersall,D., Testa,T.T., Southan,C., Ryan,D.M., Simmons,D.L., Walsh,F.S., Dingwall,C. and Christie,G.
    ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site
    Mol Cell Neurosci16, 609-619. PubMed  Europe PubMed DOI
  51. [YEAR:15-2-2000]Lin,X., Koelsch,G., Wu,S., Downs,D., Dashti,A. and Tang,J.
    Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
    Proc Natl Acad Sci U S A97, 1456-1460. PubMed  Europe PubMed
  52. Solans,A., Estivill,X. and de La Luna,S.
    A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase
    Cytogenet Cell Genet89, 177-184. PubMed  Europe PubMed
  53. Xin,H., Stephans,J.C., Duan,X., Harrowe,G., Kim,E., Grieshammer,U., Kingsley,C. and Giese,K.
    Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines
    Biochim Biophys Acta1501, 125-137. PubMed  Europe PubMed DOI
    54. 1999
  54. Saunders,A.J., Kim,T. and Tanzi,R.E.
    BACE2, a homolog of BACE, in the Down syndrome region of chromosome 21
    Science286, 1255-1255.

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