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Literature for peptidase A01.041: BACE2 g.p. (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. He,T., d'Uscio,L.V. and Katusic,Z.S. \<br\>BACE2 deficiency impairs expression and function of endothelial nitric oxide synthase in brain endothelial cells\<br\>J Neurochem (2023) 166, 928-942. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2021
  2. Fujimoto,K., Yoshida,S., Tadano,G., Asada,N., Fuchino,K., Suzuki,S., Matsuoka,E., Yamamoto,T., Yamamoto,S., Ando,S., Kanegawa,N., Tonomura,Y., Ito,H., Moechars,D., Rombouts,F.J.R., Gijsen,H.J.M. and Kusakabe,K.I. \<br\>Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective beta-Secretase (BACE1) Inhibitors over BACE2\<br\>J Med Chem (2021) 64, 3075-3085. PubMed  Europe PubMed DOI  I
  3. Yen,Y.C., Kammeyer,A.M., Tirlangi,J., Ghosh,A.K. and Mesecar,A.D. \<br\>A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors\<br\>ACS Chem Neurosci (2021) 12, 581-588. PubMed  Europe PubMed DOI
    4. 2019
  4. Ghosh,A.K., Brindisi,M., Yen,Y.C., Lendy,E.K., Kovela,S., Cardenas,E.L., Reddy,B.S., Rao,K.V., Downs,D., Huang,X., Tang,J. and Mesecar,A.D. \<br\>Highly selective and potent human beta-secretase 2 (BACE2) inhibitors against type 2 diabetes: design, synthesis, X-ray structure and structure-activity relationship studies\<br\>ChemMedChem (2019) 14, 545-560. PubMed  Europe PubMed DOI  S  I
  5. Wang,Z., Xu,Q., Cai,F., Liu,X., Wu,Y. and Song,W. \<br\>BACE2, a conditional beta-secretase, contributes to Alzheimer's disease pathogenesis\<br\>JCI Insight (2019) 4, PubMed  Europe PubMed DOI
    6. 2018
  6. Johansson,P., Kaspersson,K., Gurrell,I.K., Back,E., Eketjall,S., Scott,C.W., Cebers,G., Thorne,P., McKenzie,M.J., Beaton,H., Davey,P., Kolmodin,K., Holenz,J., Duggan,M.E., Budd Haeberlein,S. and Burli,R.W. \<br\>Toward beta-secretase-1 inhibitors with improved isoform selectivity\<br\>J Med Chem (2018) 61, 3491-3502. PubMed  Europe PubMed DOI  I
  7. Liu,F., Zhang,Y., Liang,Z., Sun,Q., Liu,H., Zhao,J., Xu,J., Zheng,J., Yun,Y., Yu,X., Song,W. and Sun,X. \<br\>Cleavage of potassium channel Kv2.1 by BACE2 reduces neuronal apoptosis\<br\>Mol Psychiatry (2018) 23, 1542-1554. PubMed  Europe PubMed DOI
    8. 2017
  8. Alcarraz-Vizan,G., Castano,C., Visa,M., Montane,J., Servitja,J.M. and Novials,A. \<br\>BACE2 suppression promotes beta-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression\<br\>Cell Mol Life Sci (2017) 74, 2827-2838. PubMed  Europe PubMed DOI
  9. Yan,R. \<br\>Physiological functions of the beta-site amyloid precursor protein cleaving enzyme 1 and 2\<br\>Front Mol Neurosci (2017) 10, 97. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2016
  10. Ghosh,A.K., Reddy,B.S., Yen,Y.C., Cardenas,E., Rao,K.V., Downs,D., Huang,X., Tang,J. and Mesecar,A.D. \<br\>Design of potent and highly selective inhibitors for human beta-secretase 2 (memapsin 1), a target for type 2 diabetes\<br\>Chem Sci (2016) 7, 3117-3122. PubMed  Europe PubMed DOI  PMC  EPMC  I
  11. Kumalo,H.M. and Soliman,M.E. \<br\>A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility\<br\>J Recept Signal Transduct Res (2016) 36, 505-514. PubMed  Europe PubMed DOI
  12. Rulifson,I.C., Cao,P., Miao,L., Kopecky,D., Huang,L., White,R.D., Samayoa,K., Gardner,J., Wu,X., Chen,K., Tsuruda,T., Homann,O., Baribault,H., Yamane,H., Carlson,T., Wiltzius,J. and Li,Y. \<br\>Identification of human islet amyloid polypeptide as a BACE2 substrate\<br\>PLoS ONE (2016) 11, e0147254. PubMed  Europe PubMed DOI  PMC  EPMC  U
  13. Shimshek,D.R., Jacobson,L.H., Kolly,C., Zamurovic,N., Balavenkatraman,K.K., Morawiec,L., Kreutzer,R., Schelle,J., Jucker,M., Bertschi,B., Theil,D., Heier,A., Bigot,K., Beltz,K., Machauer,R., Brzak,I., Perrot,L. and Neumann,U. \<br\>Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice\<br\>Sci Rep (2016) 6, 21917. PubMed  Europe PubMed DOI  PMC  EPMC  I
    14. 2015
  14. Alcarraz-Vizan,G., Casini,P., Cadavez,L., Visa,M., Montane,J., Servitja,J.M. and Novials,A. \<br\>Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic beta-cells\<br\>FASEB J (2015) 29, 95-104. PubMed  Europe PubMed DOI
  15. Vila-Real,H., Coelho,H., Rocha,J., Fernandes,A., Ventura,M.R., Maycock,C.D., Iranzo,O. and Simplicio,A.L. \<br\>Peptidomimetic beta-secretase inhibitors comprising a sequence of amyloid-beta peptide for Alzheimer's disease\<br\>J Med Chem (2015) 58, 5408-5418. PubMed  Europe PubMed DOI  I
    16. 2014
  16. Mirsafian,H., Mat Ripen,A., Merican,A.F. and Mohamad,S.B. \<br\>Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method\<br\>ScientificWorldJournal (2014) 2014, 482463. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Vassar,R., Kuhn,P.H., Haass,C., Kennedy,M.E., Rajendran,L., Wong,P.C. and Lichtenthaler,S.F. \<br\>Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects\<br\>J Neurochem (2014) 130, 4-28. PubMed  Europe PubMed DOI  K
    18. 2013
  18. Banner,D.W., Gsell,B., Benz,J., Bertschinger,J., Burger,D., Brack,S., Cuppuleri,S., Debulpaep,M., Gast,A., Grabulovski,D., Hennig,M., Hilpert,H., Huber,W., Kuglstatter,A., Kusznir,E., Laeremans,T., Matile,H., Miscenic,C., Rufer,A.C., Schlatter,D., Steyaert,J., Stihle,M., Thoma,R., Weber,M. and Ruf,A. \<br\>Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones\<br\>Acta Crystallogr D Biol Crystallogr (2013) 69, 1124-1137. PubMed  Europe PubMed DOI  S
  19. Rosse,G. \<br\>Dihydrooxazines as inhibitors of BACE-1 or BACE-2\<br\>ACS Med Chem Lett (2013) 4, 433-434. PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. Southan,C. and Hancock,J.M. \<br\>A tale of two drug targets: the evolutionary history of BACE1 and BACE2\<br\>Front Genet (2013) 4, 293. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Southan,C. \<br\>BACE2 as a new diabetes target: a patent review (2010 - 2012)\<br\>Expert Opin Ther Pat (2013) 23, 649-663. PubMed  Europe PubMed DOI  I
  22. Stutzer,I., Selevsek,N., Esterhazy,D., Schmidt,A., Aebersold,R. and Stoffel,M. \<br\>Systematic proteomic analysis identifies beta-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic beta-cells\<br\>J Biol Chem (2013) 288, 10536-10547. PubMed  Europe PubMed DOI  P
    23. 2012
  23. Abdul-Hay,S.O., Sahara,T., McBride,M., Kang,D. and Leissring,M.A. \<br\>Identification of BACE2 as an avid beta-amyloid degrading protease\<br\>Mol Neurodegener (2012) 7, 46. PubMed  Europe PubMed DOI
  24. Tang,J. and Koelsch,G. \<br\>Memapsin 1\<br\>[ISSN:978-0-12-407744-7] (2012) 3, 85-87. DOI
    25. 2011
  25. Esterhazy,D., Stutzer,I., Wang,H., Rechsteiner,M.P., Beauchamp,J., Dobeli,H., Hilpert,H., Matile,H., Prummer,M., Schmidt,A., Lieske,N., Boehm,B., Marselli,L., Bosco,D., Kerr-Conte,J., Aebersold,R., Spinas,G.A., Moch,H., Migliorini,C. and Stoffel,M. \<br\>Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass\<br\>Cell Metab (2011) 14, 365-377. PubMed  Europe PubMed DOI  K  T  I
    26. 2010
  26. Azkona,G., Levannon,D., Groner,Y. and Dierssen,M. \<br\>In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model\<br\>Amino Acids (2010) 39, 1571-1580. PubMed  Europe PubMed DOI
  27. Casas,S., Casini,P., Piquer,S., Altirriba,J., Soty,M., Cadavez,L., Gomis,R. and Novials,A. \<br\>BACE2 plays a role in the insulin receptor trafficking in pancreatic beta-cells\<br\>Am J Physiol Endocrinol Metab (2010) 299, E1087-E1095. PubMed  Europe PubMed DOI
    28. 2009
  28. Emmons,T.L., Mildner,A.M., Lull,J.M., Leone,J.W., Fischer,H.D., Heinrikson,R.L. and Tomasselli,A.G. \<br\>Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli\<br\>Protein Pept Lett (2009) 16, 121-131. PubMed  Europe PubMed DOI  E
    29. 2008
  29. Finzi,G., Franzi,F., Placidi,C., Acquati,F., Palumbo,E., Russo,A., Taramelli,R., Sessa,F. and La Rosa,S. \<br\>BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells\<br\>Ultrastruct Pathol (2008) 32, 246-251. PubMed  Europe PubMed DOI
    30. 2006
  30. [YEAR:8-11-2006]Ostermann,N., Eder,J., Eidhoff,U., Zink,F., Hassiepen,U., Worpenberg,S., Maibaum,J., Simic,O., Hommel,U. and Gerhartz,B. \<br\>Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor\<br\>J Mol Biol (8-11-2006) 355, 249-261. PubMed  Europe PubMed DOI  S  I
  31. Sun,X., He,G. and Song,W. \<br\>BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome\<br\>FASEB J (2006) 20, 1369-1376. PubMed  Europe PubMed DOI
    32. 2004
  32. Chou,K.C. \<br\>Insights from modeling the tertiary structure of human BACE2\<br\>J Proteome Res (2004) 3, 1069-1072. PubMed  Europe PubMed DOI
  33. Tang,J. and Koelsch,G. \<br\>Memapsin 1\<br\>[ISSN:0-12-079610-4] (2004) 2, 64-66.  V
  34. Vassar,R. \<br\>BACE1: the beta-secretase enzyme in Alzheimer's disease\<br\>J Mol Neurosci (2004) 23, 105-114. PubMed  Europe PubMed DOI  K
    35. 2003
  35. [YEAR:11-7-2003]Andrau,D., Dumanchin-Njock,C., Ayral,E., Vizzavona,J., Farzan,M., Boisbrun,M., Fulcrand,P., Hernandez,J.F., Martinez,J., Lefranc-Jullien,S. and Checler,F. \<br\>BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors\<br\>J Biol Chem (11-7-2003) 278, 25859-25866. PubMed  Europe PubMed DOI  A
  36. Barbiero,L., Benussi,L., Ghidoni,R., Alberici,A., Russo,C., Schettini,G., Pagano,S.F., Parati,E.A., Mazzoli,F., Nicosia,F., Signorini,S., Feudatari,E. and Binetti,G. \<br\>BACE-2 is overexpressed in Down's syndrome\<br\>Exp Neurol (2003) 182, 335-345. PubMed  Europe PubMed DOI
  37. Basi,G., Frigon,N., Barbour,R., Doan,T., Gordon,G., McConlogue,L., Sinha,S. and Zeller,M. \<br\>Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells\<br\>J Biol Chem (2003) 278, 31512-31520. PubMed  Europe PubMed DOI
  38. Vattemi,G., Engel,W.K., McFerrin,J., Pastorino,L., Buxbaum,J.D. and Askanas,V. \<br\>BACE1 and BACE2 in pathologic and normal human muscle\<br\>Exp Neurol (2003) 179, 150-158. PubMed  Europe PubMed DOI
    39. 2002
  39. Fluhrer,R., Capell,A., Westmeyer,G., Willem,M., Hartung,B., Condron,M.M., Teplow,D.B., Haass,C. and Walter,J. \<br\>A non-amyloidogenic function of BACE-2 in the secretory pathway\<br\>J Neurochem (2002) 81, 1011-1020. PubMed  Europe PubMed DOI
  40. Kim,Y.T., Downs,D., Wu,S., Dashti,A., Pan,Y., Zhai,P., Wang,X., Zhang,X.C. and Lin,X. \<br\>Enzymic properties of recombinant BACE2\<br\>Eur J Biochem (2002) 269, 5668-5677. PubMed  Europe PubMed DOI
  41. [YEAR:9-7-2002]Turner,R.T., III, Loy,J.A., Nguyen,C., Devasamudram,T., Ghosh,A.K., Koelsch,G. and Tang,J. \<br\>Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity\<br\>Biochemistry (9-7-2002) 41, 8742-8746. PubMed  Europe PubMed DOI  P  I
    42. 2001
  42. [YEAR:29-6-2001]Hussain,I., Christie,G., Schneider,K., Moore,S. and Dingwall,C. \<br\>Prodomain processing of Asp1 (BACE2) is autocatalytic\<br\>J Biol Chem (29-6-2001) 276, 23322-23328. PubMed  Europe PubMed DOI
  43. [YEAR:3-7-2001]Nowotny,P., Kwon,J.M., Chakraverty,S., Nowotny,V., Morris,J.C. and Goate,A.M. \<br\>Association studies using novel polymorphisms in BACE1 and BACE2\<br\>Neuroreport (3-7-2001) 12, 1799-1802. PubMed  Europe PubMed  M
    44. 2000
  44. [YEAR:18-2-2000]Acquati,F., Accarino,M., Nucci,C., Fumagalli,P., Jovine,L., Ottolenghi,S. and Taramelli,R. \<br\>The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region\<br\>FEBS Lett (18-2-2000) 468, 59-64. PubMed  Europe PubMed DOI
  45. [YEAR:7-7-2000]Bennett,B.D., Babu-Khan,S., Loeloff,R., Louis,J.C., Curran,E., Citron,M. and Vassar,R. \<br\>Expression analysis of BACE2 in brain and peripheral tissues\<br\>J Biol Chem (7-7-2000) 275, 20647-20651. PubMed  Europe PubMed DOI
  46. [YEAR:15-8-2000]Farzan,M., Schnitzler,C.E., Vasilieva,N., Leung,D. and Choe,H. \<br\>BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein\<br\>Proc Natl Acad Sci U S A (15-8-2000) 97, 9712-9717. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Hussain,I., Powell,D.J., Howlett,D.R., Chapman,G.A., Gilmour,L., Murdock,P.R., Tew,D.G., Meek,T.D., Chapman,C., Schneider,K., Ratcliffe,S.J., Tattersall,D., Testa,T.T., Southan,C., Ryan,D.M., Simmons,D.L., Walsh,F.S., Dingwall,C. and Christie,G. \<br\>ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site\<br\>Mol Cell Neurosci (2000) 16, 609-619. PubMed  Europe PubMed DOI
  48. [YEAR:15-2-2000]Lin,X., Koelsch,G., Wu,S., Downs,D., Dashti,A. and Tang,J. \<br\>Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein\<br\>Proc Natl Acad Sci U S A (15-2-2000) 97, 1456-1460. PubMed  Europe PubMed  PMC  EPMC
  49. Solans,A., Estivill,X. and de La Luna,S. \<br\>A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase\<br\>Cytogenet Cell Genet (2000) 89, 177-184. PubMed  Europe PubMed
  50. Xin,H., Stephans,J.C., Duan,X., Harrowe,G., Kim,E., Grieshammer,U., Kingsley,C. and Giese,K. \<br\>Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines\<br\>Biochim Biophys Acta (2000) 1501, 125-137. PubMed  Europe PubMed DOI
    51. 1999
  51. Saunders,A.J., Kim,T. and Tanzi,R.E. \<br\>BACE2, a homolog of BACE, in the Down syndrome region of chromosome 21\<br\>Science (1999) 286, 1255.

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