Literature for peptidase A01.014: candidapepsin SAP1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2018
  1. Rapala-Kozik,M., Bochenska,O., Zajac,D., Karkowska-Kuleta,J., Gogol,M., Zawrotniak,M. and Kozik,A.
    Extracellular proteinases of Candida species pathogenic yeasts
    Mol Oral Microbiol33, 113-124. PubMed  Europe PubMed DOI
  2. 2016
  3. Gogol,M., Ostrowska,D., Klaga,K., Bochenska,O., Wolak,N., Aoki,W., Ueda,M., Kozik,A. and Rapala-Kozik,M.
    Inactivation of alpha1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps
    Acta Biochim Pol63, 167-175. PubMed  Europe PubMed DOI
  4. 2013
  5. Cadicamo,C.D., Mortier,J., Wolber,G., Hell,M., Heinrich,I.E., Michel,D., Semlin,L., Berger,U., Korting,H.C., Holtje,H.D., Koksch,B. and Borelli,C.
    Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans
    Biochem Pharmacol85, 881-887. PubMed  Europe PubMed DOI  I
  6. Santos,A.L. and Braga-Silva,L.A.
    Aspartic protease inhibitors: effective drugs against the human fungal pathogen Candida albicans
    Mini Rev Med Chem13, 155-162. PubMed  Europe PubMed
  7. 2012
  8. Monod,M., Staib,P. and Borelli,C.
    Candidapepsin
    [ISSN:978-0-12-407744-7]3, 159-166. DOI
  9. Staniszewska,M., Bondaryk,M., Siennicka,K., Pilat,J., Schaller,M. and Kurzatkowski,W.
    Role of aspartic proteinases in Candida albicans virulence. Part I. Substrate specificity of aspartic proteinases and Candida albicans
    Postepy Mikrobiol51, 127-135.  V
  10. Staniszewska,M., Bondaryk,M., Siennicka,K., Pilat,J., Schaller,M. and Kurzatkowski,W.
    Role of aspartic proteinases in Candida albicans virulence. Part II: Expression of SAP1-10 aspartic proteinase during Candida albicans infections in vivo
    Postepy Mikrobiol51, 137-142.
  11. 2011
  12. Aoki,W., Kitahara,N., Miura,N., Morisaka,H., Yamamoto,Y., Kuroda,K. and Ueda,M.
    Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans
    J Biochem150, 431-438. PubMed  Europe PubMed DOI  P
  13. Braga-Silva,L.A. and Santos,A.L.S.
    Aspartic protease inhibitors as potential anti-Candida albicans drugs: impacts on fungal biology, virulence and pathogenesis
    Curr Med Chem18, 2401-2419. PubMed  Europe PubMed DOI  I
  14. Buchold,C., Hemberger,Y., Heindl,C., Welker,A., Degel,B., Pfeuffer,T., Staib,P., Schneider,S., Rosenthal,P.J., Gut,J., Morschhauser,J., Bringmann,G. and Schirmeister,T.
    New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors
    ChemMedChem6, 141-152. PubMed  Europe PubMed DOI  I
  15. 2010
  16. Correia,A., Lermann,U., Teixeira,L., Cerca,F., Botelho,S., Gil Da Costa,R.M., Sampaio,P., Gartner,F., Morschhauser,J., Vilanova,M. and Pais,C.
    Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis
    Infect Immun78, 4839-4849. PubMed  Europe PubMed DOI
  17. Pietrella,D., Rachini,A., Pandey,N., Schild,L., Netea,M., Bistoni,F., Hube,B. and Vecchiarelli,A.
    The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity
    Infect Immun78, 4754-4762. PubMed  Europe PubMed DOI
  18. 2009
  19. Gropp,K., Schild,L., Schindler,S., Hube,B., Zipfel,P.F. and Skerka,C.
    The yeast Candida albicans evades human complement attack by secretion of aspartic proteases
    Mol Immunol47, 465-475. PubMed  Europe PubMed DOI
  20. Parra-Ortega,B., Cruz-Torres,H., Villa-Tanaca,L. and Hernandez-Rodriguez,C.
    Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species
    Mem Inst Oswaldo Cruz104, 505-512. PubMed  Europe PubMed
  21. 2008
  22. Borelli,C., Ruge,E., Lee,J.H., Schaller,M., Vogelsang,A., Monod,M., Korting,H.C., Huber,R. and Maskos,K.
    X-ray structures of Sap1 and Sap5: structural comparison of the secreted aspartic proteinases from Candida albicans
    Proteins72, 1308-1319. PubMed  Europe PubMed DOI  S
  23. Lermann,U. and Morschhauser,J.
    Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans
    Microbiology (Reading)154, 3281-3295. PubMed  Europe PubMed DOI
  24. Naglik,J.R., Moyes,D., Makwana,J., Kanzaria,P., Tsichlaki,E., Weindl,G., Tappuni,A.R., Rodgers,C.A., Woodman,A.J., Challacombe,S.J., Schaller,M. and Hube,B.
    Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis
    Microbiology (Reading)154, 3266-3280. PubMed  Europe PubMed DOI
  25. Odds,F.C.
    Secreted proteinases and Candida albicans virulence
    Microbiology (Reading)154, 3245-3246. PubMed  Europe PubMed DOI
  26. Staib,P., Lermann,U., Blass-Warmuth,J., Degel,B., Wurzner,R., Monod,M., Schirmeister,T. and Morschhauser,J.
    Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening
    Antimicrob Agents Chemother52, 146-156. PubMed  Europe PubMed DOI
  27. 2006
  28. Majer,F., Pavlickova,L., Majer,P., Hradilek,M., Dolejsi,E., Hruskova-Heidingsfeldova,O. and Pichova,I.
    Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
    Biol Chem387, 1247-1254. PubMed  Europe PubMed DOI  P  I
  29. 2004
  30. Foundling,S.I.
    Candidapepsin
    [ISSN:0-12-079610-4]2, 115-120.  V
  31. 2003
  32. [YEAR:21-3-2003]Backman,D. and Danielson,U.H.
    Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans
    Biochim Biophys Acta1646, 184-195. PubMed  Europe PubMed DOI  I
  33. Korting,H.C., Hube,B., Oberbauer,S., Januschke,E., Hamm,G., Albrecht,A., Borelli,C. and Schaller,M.
    Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium
    J Med Microbiol52, 623-632. PubMed  Europe PubMed DOI
  34. Naglik,J.R., Challacombe,S.J. and Hube,B.
    Candida albicans secreted aspartyl proteinases in virulence and pathogenesis
    Microbiol Mol Biol Rev67, 400-428. PubMed  Europe PubMed DOI
  35. Schaller,M., Bein,M., Korting,H.C., Baur,S., Hamm,G., Monod,M., Beinhauer,S. and Hube,B.
    The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium
    Infect Immun71, 3227-3234. PubMed  Europe PubMed DOI  I
  36. 2002
  37. Felk,A., Kretschmar,M., Albrecht,A., Schaller,M., Beinhauer,S., Nichterlein,T., Sanglard,D., Korting,H.C., Schafer,W. and Hube,B.
    Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs
    Infect Immun70, 3689-3700. PubMed  Europe PubMed DOI
  38. Kretschmar,M., Felk,A., Staib,P., Schaller,M., Hess,D., Callapina,M., Morschhauser,J., Schafer,W., Korting,H.C., Hof,H., Hube,B. and Nichterlein,T.
    Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice
    Microb Pathog32, 61-70. PubMed  Europe PubMed DOI
  39. 2001
  40. De Bernardis,F., Sullivan,P.A. and Cassone,A.
    Aspartyl proteinases of Candida albicans and their role in pathogenicity
    Med Mycol39, 303-313. PubMed  Europe PubMed
  41. Hube,B. and Naglik,J.
    Candida albicans proteinases: resolving the mystery of a gene family
    Microbiology (Reading, Engl )147, 1997-2005. PubMed  Europe PubMed
  42. Pichova,I., Pavlickova,L., Dostal,J., Dolejsi,E., Hruskova-Heidingsfeldova,O., Weber,J., Ruml,T. and Soucek,M.
    Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors
    Eur J Biochem268, 2669-2677. PubMed  Europe PubMed DOI  I
  43. Schaller,M., Januschke,E., Schackert,C., Woerle,B. and Korting,H.C.
    Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo
    J Med Microbiol50, 743-747. PubMed  Europe PubMed
  44. Stewart,K. and Abad-Zapatero,C.
    Candida proteases and their inhibition: prospects for antifungal therapy
    Curr Med Chem8, 941-948. PubMed  Europe PubMed  I
  45. 2000
  46. Beggah,S., Lechenne,B., Reichard,U., Foundling,S. and Monod,M.
    Intra- and intermolecular events direct the propeptide-mediated maturation of the Candida albicans secreted aspartic proteinase Sap1p
    Microbiology (Reading, Engl )146, 2765-2773. PubMed  Europe PubMed
  47. [YEAR:14-7-2000]Koelsch,G., Tang,J., Loy,J.A., Monod,M., Jackson,K., Foundling,S.I. and Lin,X.L.
    Enzymic characteristics of secreted aspartic proteases of Candida albicans
    Biochim Biophys Acta1480, 117-131. PubMed  Europe PubMed DOI
  48. Schaller,M., Schackert,C., Korting,H.C., Januschke,E. and Hube,B.
    Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis
    J Invest Dermatol114, 712-717. PubMed  Europe PubMed DOI
  49. [YEAR:23-5-2000]Staib,P., Kretschmar,M., Nichterlein,T., Hof,H. and Morschhauser,J.
    Differential activation of a Candida albicans virulence gene family during infection
    Proc Natl Acad Sci U S A97, 6102-6107. PubMed  Europe PubMed DOI
  50. Stehr,F., Felk,A., Kretschmar,M., Schaller,M., Schafer,W. and Hube,B.
    [Extracellular hydrolytic enzymes and their relevance during Candida albicans infections]
    Mycoses43 Suppl 2, 17-21. PubMed  Europe PubMed
  51. 1999
  52. Borg-von Zepelin,M., Meyer,I., Thomssen,R., Wurzner,R., Sanglard,D., Telenti,A. and Monod,M.
    HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases
    J Invest Dermatol113, 747-751. PubMed  Europe PubMed DOI  I
  53. Gruber,A., Berlit,J., Speth,C., Lass-Florl,C., Kofler,G., Nagl,M., Borg-von Zepelin,M., Dierich,M.P. and Wurzner,R.
    Dissimilar attenuation of Candida albicans virulence properties by human immunodeficiency virus type 1 protease inhibitors
    Immunobiology201, 133-144. PubMed  Europe PubMed DOI  I
  54. Korting,H.C., Schaller,M., Eder,G., Hamm,G., Bohmer,U. and Hube,B.
    Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-Infected patients
    Antimicrobial Agents Chemother43, 2038-2042. PubMed  Europe PubMed  I
  55. Kretschmar,M., Hube,B., Bertsch,T., Sanglard,D., Merker,R., Schroder,M., Hof,H. and Nichterlein,T.
    Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis
    Infect Immun67, 6637-6642. PubMed  Europe PubMed
  56. Monod,M., Borg-von Zepelin,M., Telenti,A. and Sanglard,D.
    The inhibition of Candida-albicans-secreted aspartic proteases by three different HIV protease inhibitors
    Dermatology198, 412-414. PubMed  Europe PubMed  I
  57. Na,B.K. and Song,C.Y.
    Use of monoclonal antibody in diagnosis of candidiasis caused by Candida albicans: Detection of circulating aspartyl proteinase antigen
    Clin Diagn Lab Immunol6, 924-929. PubMed  Europe PubMed
  58. Schaller,M., Korting,H.C., Schafer,W., Bastert,J., Chen,W. and Hube,B.
    Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis
    Mol Microbiol34, 169-180. PubMed  Europe PubMed DOI
  59. 1998
  60. Borg-von Zepelin,M., Beggah,S., Boggian,K., Sanglard,D. and Monod,M.
    The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages
    Mol Microbiol28, 543-554. PubMed  Europe PubMed DOI  E
  61. Monod,M., Hube,B., Hess,D. and Sanglard,D.
    Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans
    Microbiology (Reading, Engl )144, 2731-2737. PubMed  Europe PubMed
  62. Pichova,I., Brozkova,K., Pavlickova,L., Fusek,M., Krizova,I., Ruml,T. and Soucek,M.
    Development and testing of inhibitors of Candida aspartic proteinases
    Adv Exp Med Biol436, 329-333. PubMed  Europe PubMed
  63. 1997
  64. Hube,B., Sanglard,D., Odds,F.C., Hess,D., Monod,M., Schafer,W., Brown,A.J. and Gow,N.A.
    Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence
    Infect Immun65, 3529-3538. PubMed  Europe PubMed
  65. Smolenski,G., Sullivan,P.A., Cutfield,S.M. and Cutfield,J.F.
    Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes
    Microbiology (Reading, Engl )143, 349-356. PubMed  Europe PubMed
  66. 1996
  67. Hoegl,L., Ollert,M. and Korting,H.C.
    The role of Candida albicans secreted aspartic proteinase in the development of candidoses
    J Mol Med74, 135-142. PubMed  Europe PubMed DOI
  68. 1995
  69. White,T.C., Andrews,L.E., Maltby,D. and Agabian,N.
    The "universal" leucine codon CTG in the secreted aspartyl proteinase 1 (SAP1) gene of Candida albicans encodes a serine in vivo
    J Bacteriol177, 2953-2955. PubMed  Europe PubMed
  70. 1994
  71. Fusek,M., Smith,E.A., Monod,M., Dunn,B.M. and Foundling,S.I.
    Extracellular aspartic proteinases from Candida albicans, Candida tropicalis, and Candida parapsilosis yeasts differ substantially in their specificities
    Biochemistry33, 9791-9799. PubMed  Europe PubMed
  72. Hube,B., Monod,M., Schofield,D.A., Brown,A.J. and Gow,N.A.
    Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans
    Mol Microbiol14, 87-99. PubMed  Europe PubMed DOI
  73. Miyasaki,S.H., White,T.C. and Agabian,N.
    A fourth secreted aspartyl proteinase gene (SAP4) and a CARE2 repetitive element are located upstream of the SAP1 gene in Candida albicans
    J Bacteriol176, 1702-1710. PubMed  Europe PubMed
  74. Monod,M., Togni,G., Hube,B. and Sanglard,D.
    Multiplicity of genes encoding secreted aspartic proteinases in Candida species
    Mol Microbiol13, 357-368. PubMed  Europe PubMed DOI
  75. Odds,F.C.
    Pathogenesis of Candida infections
    J Am Acad Dermatol31, S2-S5. PubMed  Europe PubMed
  76. Tsushima,H., Mine,H., Kawakami,Y., Hyodoh,F. and Ueki,A.
    Candida albicans aspartic proteinase cleaves and inactivates human epidermal cysteine proteinase inhibitor, cystatin A
    Microbiology (Reading, Engl )140, 167-171. PubMed  Europe PubMed
  77. 1993
  78. Ogrydziak,D.M.
    Yeast extracellular proteases
    Crit Rev Biotechnol13, 1-55. PubMed  Europe PubMed DOI
  79. White,T.C., Miyasaki,S.H. and Agabian,N.
    Three distinct secreted aspartyl proteinases in Candida albicans
    J Bacteriol175, 6126-6133. PubMed  Europe PubMed
  80. 1992
  81. Capobianco,J.O., Lerner,C.G. and Goldman,R.C.
    Application of a fluorogenic substrate in the assay of proteolytic activity and in the discovery of a potent inhibitor of Candida albicans aspartic proteinase
    Anal Biochem204, 96-102. PubMed  Europe PubMed DOI  I
  82. Mukai,H., Takeda,O., Asada,K., Kato,I., Murayama,S.Y. and Yamaguchi,H.
    cDNA cloning of an aspartic proteinase secreted by Candida albicans
    Microbiol Immunol36, 1207-1216. PubMed  Europe PubMed
  83. Mukai,H., Takeda,O., Asada,K., Kato,I., Murayama,S.Y. and Yamaguchi,H.
    cDNA cloning of an aspartic proteinase secreted by Candida albicans
    Microbiol Immunol36, 105-111.
  84. Sono,E., Masuda,T., Takesako,K., Kato,I., Uchida,K., Murayama,S.Y. and Yamaguchi,H.
    Comparison of secretory acid proteinases from Candida tropicalis, C. parapsilosis and C. albicans
    Microbiol Immunol36, 1099-1104. PubMed  Europe PubMed
  85. 1991
  86. Ganesan,K., Banerjee,A. and Datta,A.
    Molecular cloning of the secretory acid proteinase gene from Candida albicans and its use as a species-specific probe
    Infect Immun59, 2972-2977. PubMed  Europe PubMed
  87. Hube,B., Turver,C.J., Odds,F.C., Eiffert,H., Boulnois,G.J., Kochel,H. and Ruchel,R.
    Sequence of the Candida albicans gene encoding the secretory aspartate proteinase
    Med Mycol29, 129-132. DOI
  88. Hube,B., Turver,C.J., Odds,F.C., Eiffert,H., Boulnois,G.J., Kochel,H. and Ruchel,R.
    Sequence of the Candida albicans gene encoding the secretory aspartate proteinase
    J Med Vet Mycol29, 129-132. PubMed  Europe PubMed
  89. 1990
  90. Ross,I.K., De Bernardis,F., Emerson,G.W., Cassone,A. and Sullivan,P.A.
    The secreted aspartate proteinase of Candida albicans: physiology of secretion and virulence of a proteinase-deficient mutant
    J Gen Microbiol136, 687-694. PubMed  Europe PubMed
  91. 1989
  92. Lott,T.J., Page,L.S., Boiron,P., Benson,J. and Reiss,E.
    Nucleotide sequence of the Candida albicans aspartyl proteinase gene
    Nucleic Acids Res17, 1779-1779. PubMed  Europe PubMed
  93. 1988
  94. Borg,M. and Ruchel,R.
    Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa
    Infect Immun56, 626-631. PubMed  Europe PubMed
  95. 1986
  96. Ruchel,R.
    Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida
    Microbiol Sci3, 316-319. PubMed  Europe PubMed
  97. 1984
  98. Negi,M., Tsuboi,R., Matsui,T. and Ogawa,H.
    Isolation and characterization of proteinase from Candida albicans: substrate specificity
    J Invest Dermatol83, 32-36. PubMed  Europe PubMed  P
  99. 1983
  100. Ruchel,R.
    On the renin-like activity of Candida proteinases and activation of blood coagulation in vitro
    Zentralbl Bakteriol Mikrobiol Hyg A255, 368-379. PubMed  Europe PubMed
  101. 1981
  102. Ruchel,R.
    Properties of a purified proteinase from the yeast Candida albicans
    Biochim Biophys Acta659, 99-113. PubMed  Europe PubMed
  103. 1968
  104. Remold,H., Fasold,H. and Staib,F.
    Purification and characterization of a proteolytic enzyme from Candida albicans
    Biochim Biophys Acta167, 399-406. PubMed  Europe PubMed