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Literature for peptidase A01.014: candidapepsin SAP1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2018
  1. Rapala-Kozik,M., Bochenska,O., Zajac,D., Karkowska-Kuleta,J., Gogol,M., Zawrotniak,M. and Kozik,A.<br>Extracellular proteinases of Candida species pathogenic yeasts<br>Mol Oral Microbiol (2018) 33, 113-124. PubMed  Europe PubMed DOI
    2. 2016
  2. Gogol,M., Ostrowska,D., Klaga,K., Bochenska,O., Wolak,N., Aoki,W., Ueda,M., Kozik,A. and Rapala-Kozik,M.<br>Inactivation of alpha1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps<br>Acta Biochim Pol (2016) 63, 167-175. PubMed  Europe PubMed DOI
    3. 2013
  3. Cadicamo,C.D., Mortier,J., Wolber,G., Hell,M., Heinrich,I.E., Michel,D., Semlin,L., Berger,U., Korting,H.C., Holtje,H.D., Koksch,B. and Borelli,C.<br>Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans<br>Biochem Pharmacol (2013) 85, 881-887. PubMed  Europe PubMed DOI  I
  4. Santos,A.L. and Braga-Silva,L.A.<br>Aspartic protease inhibitors: effective drugs against the human fungal pathogen Candida albicans<br>Mini Rev Med Chem (2013) 13, 155-162. PubMed  Europe PubMed
    5. 2012
  5. Monod,M., Staib,P. and Borelli,C.<br>Candidapepsin<br>[ISSN:978-0-12-407744-7] (2012) 3, 159-166. DOI
  6. Staniszewska,M., Bondaryk,M., Siennicka,K., Pilat,J., Schaller,M. and Kurzatkowski,W.<br>Role of aspartic proteinases in Candida albicans virulence. Part II: Expression of SAP1-10 aspartic proteinase during Candida albicans infections in vivo<br>Postepy Mikrobiol (2012) 51, 137-142.
  7. Staniszewska,M., Bondaryk,M., Siennicka,K., Pilat,J., Schaller,M. and Kurzatkowski,W.<br>Role of aspartic proteinases in Candida albicans virulence. Part I. Substrate specificity of aspartic proteinases and Candida albicans<br>Postepy Mikrobiol (2012) 51, 127-135.  V
    8. 2011
  8. Aoki,W., Kitahara,N., Miura,N., Morisaka,H., Yamamoto,Y., Kuroda,K. and Ueda,M.<br>Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans<br>J Biochem (2011) 150, 431-438. PubMed  Europe PubMed DOI  P
  9. Braga-Silva,L.A. and Santos,A.L.S.<br>Aspartic protease inhibitors as potential anti-Candida albicans drugs: impacts on fungal biology, virulence and pathogenesis<br>Curr Med Chem (2011) 18, 2401-2419. PubMed  Europe PubMed DOI  I
  10. Buchold,C., Hemberger,Y., Heindl,C., Welker,A., Degel,B., Pfeuffer,T., Staib,P., Schneider,S., Rosenthal,P.J., Gut,J., Morschhauser,J., Bringmann,G. and Schirmeister,T.<br>New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors<br>ChemMedChem (2011) 6, 141-152. PubMed  Europe PubMed DOI  I
    11. 2010
  11. Correia,A., Lermann,U., Teixeira,L., Cerca,F., Botelho,S., Gil Da Costa,R.M., Sampaio,P., Gartner,F., Morschhauser,J., Vilanova,M. and Pais,C.<br>Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis<br>Infect Immun (2010) 78, 4839-4849. PubMed  Europe PubMed DOI
  12. Pietrella,D., Rachini,A., Pandey,N., Schild,L., Netea,M., Bistoni,F., Hube,B. and Vecchiarelli,A.<br>The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity<br>Infect Immun (2010) 78, 4754-4762. PubMed  Europe PubMed DOI
    13. 2009
  13. Gropp,K., Schild,L., Schindler,S., Hube,B., Zipfel,P.F. and Skerka,C.<br>The yeast Candida albicans evades human complement attack by secretion of aspartic proteases<br>Mol Immunol (2009) 47, 465-475. PubMed  Europe PubMed DOI
  14. Parra-Ortega,B., Cruz-Torres,H., Villa-Tanaca,L. and Hernandez-Rodriguez,C.<br>Phylogeny and evolution of the aspartyl protease family from clinically relevant Candida species<br>Mem Inst Oswaldo Cruz (2009) 104, 505-512. PubMed  Europe PubMed
    15. 2008
  15. Borelli,C., Ruge,E., Lee,J.H., Schaller,M., Vogelsang,A., Monod,M., Korting,H.C., Huber,R. and Maskos,K.<br>X-ray structures of Sap1 and Sap5: structural comparison of the secreted aspartic proteinases from Candida albicans<br>Proteins (2008) 72, 1308-1319. PubMed  Europe PubMed DOI  S
  16. Lermann,U. and Morschhauser,J.<br>Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans<br>Microbiology (Reading) (2008) 154, 3281-3295. PubMed  Europe PubMed DOI
  17. Naglik,J.R., Moyes,D., Makwana,J., Kanzaria,P., Tsichlaki,E., Weindl,G., Tappuni,A.R., Rodgers,C.A., Woodman,A.J., Challacombe,S.J., Schaller,M. and Hube,B.<br>Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis<br>Microbiology (Reading) (2008) 154, 3266-3280. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Odds,F.C.<br>Secreted proteinases and Candida albicans virulence<br>Microbiology (Reading) (2008) 154, 3245-3246. PubMed  Europe PubMed DOI
  19. Staib,P., Lermann,U., Blass-Warmuth,J., Degel,B., Wurzner,R., Monod,M., Schirmeister,T. and Morschhauser,J.<br>Tetracycline-inducible expression of individual secreted aspartic proteases in Candida albicans allows isoenzyme-specific inhibitor screening<br>Antimicrob Agents Chemother (2008) 52, 146-156. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 2006
  20. Majer,F., Pavlickova,L., Majer,P., Hradilek,M., Dolejsi,E., Hruskova-Heidingsfeldova,O. and Pichova,I.<br>Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling<br>Biol Chem (2006) 387, 1247-1254. PubMed  Europe PubMed DOI  P  I
    21. 2004
  21. Foundling,S.I.<br>Candidapepsin<br>[ISSN:0-12-079610-4] (2004) 2, 115-120.  V
    22. 2003
  22. [YEAR:21-3-2003]Backman,D. and Danielson,U.H.<br>Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans<br>Biochim Biophys Acta (21-3-2003) 1646, 184-195. PubMed  Europe PubMed DOI  I
  23. Korting,H.C., Hube,B., Oberbauer,S., Januschke,E., Hamm,G., Albrecht,A., Borelli,C. and Schaller,M.<br>Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium<br>J Med Microbiol (2003) 52, 623-632. PubMed  Europe PubMed DOI
  24. Naglik,J.R., Challacombe,S.J. and Hube,B.<br>Candida albicans secreted aspartyl proteinases in virulence and pathogenesis<br>Microbiol Mol Biol Rev (2003) 67, 400-428. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Schaller,M., Bein,M., Korting,H.C., Baur,S., Hamm,G., Monod,M., Beinhauer,S. and Hube,B.<br>The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium<br>Infect Immun (2003) 71, 3227-3234. PubMed  Europe PubMed DOI  PMC  EPMC  I
    26. 2002
  26. Felk,A., Kretschmar,M., Albrecht,A., Schaller,M., Beinhauer,S., Nichterlein,T., Sanglard,D., Korting,H.C., Schafer,W. and Hube,B.<br>Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs<br>Infect Immun (2002) 70, 3689-3700. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Kretschmar,M., Felk,A., Staib,P., Schaller,M., Hess,D., Callapina,M., Morschhauser,J., Schafer,W., Korting,H.C., Hof,H., Hube,B. and Nichterlein,T.<br>Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice<br>Microb Pathog (2002) 32, 61-70. PubMed  Europe PubMed DOI
    28. 2001
  28. De Bernardis,F., Sullivan,P.A. and Cassone,A.<br>Aspartyl proteinases of Candida albicans and their role in pathogenicity<br>Med Mycol (2001) 39, 303-313. PubMed  Europe PubMed
  29. Hube,B. and Naglik,J.<br>Candida albicans proteinases: resolving the mystery of a gene family<br>Microbiology (Reading, Engl.) (2001) 147, 1997-2005. PubMed  Europe PubMed
  30. Pichova,I., Pavlickova,L., Dostal,J., Dolejsi,E., Hruskova-Heidingsfeldova,O., Weber,J., Ruml,T. and Soucek,M.<br>Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors<br>Eur J Biochem (2001) 268, 2669-2677. PubMed  Europe PubMed DOI  I
  31. Schaller,M., Januschke,E., Schackert,C., Woerle,B. and Korting,H.C.<br>Different isoforms of secreted aspartyl proteinases (Sap) are expressed by Candida albicans during oral and cutaneous candidosis in vivo<br>J Med Microbiol (2001) 50, 743-747. PubMed  Europe PubMed
  32. Stewart,K. and Abad-Zapatero,C.<br>Candida proteases and their inhibition: prospects for antifungal therapy<br>Curr Med Chem (2001) 8, 941-948. PubMed  Europe PubMed  I
    33. 2000
  33. Beggah,S., Lechenne,B., Reichard,U., Foundling,S. and Monod,M.<br>Intra- and intermolecular events direct the propeptide-mediated maturation of the Candida albicans secreted aspartic proteinase Sap1p<br>Microbiology (Reading, Engl.) (2000) 146, 2765-2773. PubMed  Europe PubMed
  34. [YEAR:14-7-2000]Koelsch,G., Tang,J., Loy,J.A., Monod,M., Jackson,K., Foundling,S.I. and Lin,X.L.<br>Enzymic characteristics of secreted aspartic proteases of Candida albicans<br>Biochim Biophys Acta (14-7-2000) 1480, 117-131. PubMed  Europe PubMed DOI
  35. Schaller,M., Schackert,C., Korting,H.C., Januschke,E. and Hube,B.<br>Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis<br>J Invest Dermatol (2000) 114, 712-717. PubMed  Europe PubMed DOI
  36. [YEAR:23-5-2000]Staib,P., Kretschmar,M., Nichterlein,T., Hof,H. and Morschhauser,J.<br>Differential activation of a Candida albicans virulence gene family during infection<br>Proc Natl Acad Sci U S A (23-5-2000) 97, 6102-6107. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Stehr,F., Felk,A., Kretschmar,M., Schaller,M., Schafer,W. and Hube,B.<br>[Extracellular hydrolytic enzymes and their relevance during Candida albicans infections]<br>Mycoses (2000) 43 Suppl 2, 17-21. PubMed  Europe PubMed
    38. 1999
  38. Borg-von Zepelin,M., Meyer,I., Thomssen,R., Wurzner,R., Sanglard,D., Telenti,A. and Monod,M.<br>HIV-protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases<br>J Invest Dermatol (1999) 113, 747-751. PubMed  Europe PubMed DOI  I
  39. Gruber,A., Berlit,J., Speth,C., Lass-Florl,C., Kofler,G., Nagl,M., Borg-von Zepelin,M., Dierich,M.P. and Wurzner,R.<br>Dissimilar attenuation of Candida albicans virulence properties by human immunodeficiency virus type 1 protease inhibitors<br>Immunobiology (1999) 201, 133-144. PubMed  Europe PubMed DOI  I
  40. Korting,H.C., Schaller,M., Eder,G., Hamm,G., Bohmer,U. and Hube,B.<br>Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-Infected patients<br>Antimicrobial Agents Chemother (1999) 43, 2038-2042. PubMed  Europe PubMed  PMC  EPMC  I
  41. Kretschmar,M., Hube,B., Bertsch,T., Sanglard,D., Merker,R., Schroder,M., Hof,H. and Nichterlein,T.<br>Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis<br>Infect Immun (1999) 67, 6637-6642. PubMed  Europe PubMed  PMC  EPMC
  42. Monod,M., Borg-von Zepelin,M., Telenti,A. and Sanglard,D.<br>The inhibition of Candida-albicans-secreted aspartic proteases by three different HIV protease inhibitors<br>Dermatology (1999) 198, 412-414. PubMed  Europe PubMed  I
  43. Na,B.K. and Song,C.Y.<br>Use of monoclonal antibody in diagnosis of candidiasis caused by Candida albicans: Detection of circulating aspartyl proteinase antigen<br>Clin Diagn Lab Immunol (1999) 6, 924-929. PubMed  Europe PubMed  PMC  EPMC
  44. Schaller,M., Korting,H.C., Schafer,W., Bastert,J., Chen,W. and Hube,B.<br>Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis<br>Mol Microbiol (1999) 34, 169-180. PubMed  Europe PubMed DOI
    45. 1998
  45. Borg-von Zepelin,M., Beggah,S., Boggian,K., Sanglard,D. and Monod,M.<br>The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages<br>Mol Microbiol (1998) 28, 543-554. PubMed  Europe PubMed DOI  E
  46. Monod,M., Hube,B., Hess,D. and Sanglard,D.<br>Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans<br>Microbiology (Reading, Engl.) (1998) 144, 2731-2737. PubMed  Europe PubMed
  47. Pichova,I., Brozkova,K., Pavlickova,L., Fusek,M., Krizova,I., Ruml,T. and Soucek,M.<br>Development and testing of inhibitors of Candida aspartic proteinases<br>Adv Exp Med Biol (1998) 436, 329-333. PubMed  Europe PubMed
    48. 1997
  48. Hube,B., Sanglard,D., Odds,F.C., Hess,D., Monod,M., Schafer,W., Brown,A.J. and Gow,N.A.<br>Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence<br>Infect Immun (1997) 65, 3529-3538. PubMed  Europe PubMed  PMC  EPMC
  49. Smolenski,G., Sullivan,P.A., Cutfield,S.M. and Cutfield,J.F.<br>Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes<br>Microbiology (Reading, Engl.) (1997) 143, 349-356. PubMed  Europe PubMed
    50. 1996
  50. Hoegl,L., Ollert,M. and Korting,H.C.<br>The role of Candida albicans secreted aspartic proteinase in the development of candidoses<br>J Mol Med (1996) 74, 135-142. PubMed  Europe PubMed DOI
    51. 1995
  51. White,T.C., Andrews,L.E., Maltby,D. and Agabian,N.<br>The "universal" leucine codon CTG in the secreted aspartyl proteinase 1 (SAP1) gene of Candida albicans encodes a serine in vivo<br>J Bacteriol (1995) 177, 2953-2955. PubMed  Europe PubMed  PMC  EPMC
    52. 1994
  52. Fusek,M., Smith,E.A., Monod,M., Dunn,B.M. and Foundling,S.I.<br>Extracellular aspartic proteinases from Candida albicans, Candida tropicalis, and Candida parapsilosis yeasts differ substantially in their specificities<br>Biochemistry (1994) 33, 9791-9799. PubMed  Europe PubMed
  53. Hube,B., Monod,M., Schofield,D.A., Brown,A.J. and Gow,N.A.<br>Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans<br>Mol Microbiol (1994) 14, 87-99. PubMed  Europe PubMed DOI
  54. Miyasaki,S.H., White,T.C. and Agabian,N.<br>A fourth secreted aspartyl proteinase gene (SAP4) and a CARE2 repetitive element are located upstream of the SAP1 gene in Candida albicans<br>J Bacteriol (1994) 176, 1702-1710. PubMed  Europe PubMed  PMC  EPMC
  55. Monod,M., Togni,G., Hube,B. and Sanglard,D.<br>Multiplicity of genes encoding secreted aspartic proteinases in Candida species<br>Mol Microbiol (1994) 13, 357-368. PubMed  Europe PubMed DOI
  56. Odds,F.C.<br>Pathogenesis of Candida infections<br>J Am Acad Dermatol (1994) 31, S2-S5. PubMed  Europe PubMed
  57. Tsushima,H., Mine,H., Kawakami,Y., Hyodoh,F. and Ueki,A.<br>Candida albicans aspartic proteinase cleaves and inactivates human epidermal cysteine proteinase inhibitor, cystatin A<br>Microbiology (Reading, Engl.) (1994) 140, 167-171. PubMed  Europe PubMed
    58. 1993
  58. Ogrydziak,D.M.<br>Yeast extracellular proteases<br>Crit Rev Biotechnol (1993) 13, 1-55. PubMed  Europe PubMed DOI
  59. White,T.C., Miyasaki,S.H. and Agabian,N.<br>Three distinct secreted aspartyl proteinases in Candida albicans<br>J Bacteriol (1993) 175, 6126-6133. PubMed  Europe PubMed  PMC  EPMC
    60. 1992
  60. Capobianco,J.O., Lerner,C.G. and Goldman,R.C.<br>Application of a fluorogenic substrate in the assay of proteolytic activity and in the discovery of a potent inhibitor of Candida albicans aspartic proteinase<br>Anal Biochem (1992) 204, 96-102. PubMed  Europe PubMed DOI  I
  61. Mukai,H., Takeda,O., Asada,K., Kato,I., Murayama,S.Y. and Yamaguchi,H.<br>cDNA cloning of an aspartic proteinase secreted by Candida albicans<br>Microbiol Immunol (1992) 36, 1207-1216. PubMed  Europe PubMed
  62. Mukai,H., Takeda,O., Asada,K., Kato,I., Murayama,S.Y. and Yamaguchi,H.<br>cDNA cloning of an aspartic proteinase secreted by Candida albicans<br>Microbiol Immunol (1992) 36, 105-111.
  63. Sono,E., Masuda,T., Takesako,K., Kato,I., Uchida,K., Murayama,S.Y. and Yamaguchi,H.<br>Comparison of secretory acid proteinases from Candida tropicalis, C. parapsilosis and C. albicans<br>Microbiol Immunol (1992) 36, 1099-1104. PubMed  Europe PubMed
    64. 1991
  64. Ganesan,K., Banerjee,A. and Datta,A.<br>Molecular cloning of the secretory acid proteinase gene from Candida albicans and its use as a species-specific probe<br>Infect Immun (1991) 59, 2972-2977. PubMed  Europe PubMed  PMC  EPMC
  65. Hube,B., Turver,C.J., Odds,F.C., Eiffert,H., Boulnois,G.J., Kochel,H. and Ruchel,R.<br>Sequence of the Candida albicans gene encoding the secretory aspartate proteinase<br>J Med Vet Mycol (1991) 29, 129-132. PubMed  Europe PubMed
  66. Hube,B., Turver,C.J., Odds,F.C., Eiffert,H., Boulnois,G.J., Kochel,H. and Ruchel,R.<br>Sequence of the Candida albicans gene encoding the secretory aspartate proteinase<br>Med Mycol (1991) 29, 129-132. DOI
    67. 1990
  67. Ross,I.K., De Bernardis,F., Emerson,G.W., Cassone,A. and Sullivan,P.A.<br>The secreted aspartate proteinase of Candida albicans: physiology of secretion and virulence of a proteinase-deficient mutant<br>J Gen Microbiol (1990) 136, 687-694. PubMed  Europe PubMed
    68. 1989
  68. Lott,T.J., Page,L.S., Boiron,P., Benson,J. and Reiss,E.<br>Nucleotide sequence of the Candida albicans aspartyl proteinase gene<br>Nucleic Acids Res (1989) 17, 1779-1779. PubMed  Europe PubMed  PMC  EPMC
    69. 1988
  69. Borg,M. and Ruchel,R.<br>Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa<br>Infect Immun (1988) 56, 626-631. PubMed  Europe PubMed  PMC  EPMC
    70. 1986
  70. Ruchel,R.<br>Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida<br>Microbiol Sci (1986) 3, 316-319. PubMed  Europe PubMed
    71. 1984
  71. Negi,M., Tsuboi,R., Matsui,T. and Ogawa,H.<br>Isolation and characterization of proteinase from Candida albicans: substrate specificity<br>J Invest Dermatol (1984) 83, 32-36. PubMed  Europe PubMed  P
    72. 1983
  72. Ruchel,R.<br>On the renin-like activity of Candida proteinases and activation of blood coagulation in vitro<br>Zentralbl Bakteriol Mikrobiol Hyg A (1983) 255, 368-379. PubMed  Europe PubMed
    73. 1981
  73. Ruchel,R.<br>Properties of a purified proteinase from the yeast Candida albicans<br>Biochim Biophys Acta (1981) 659, 99-113. PubMed  Europe PubMed
    74. 1968
  74. Remold,H., Fasold,H. and Staib,F.<br>Purification and characterization of a proteolytic enzyme from Candida albicans<br>Biochim Biophys Acta (1968) 167, 399-406. PubMed  Europe PubMed

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