$VAR1 = undef;

Summary for peptidase A01.014: candidapepsin SAP1

Names
MEROPS Name	candidapepsin SAP1
Other names	secreted aspartic proteinase 1 (Candida albicans), SAP1 g.p. (Candida albicans), SAP1 proteinase (Candida albicans)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.014
Holotype	candidapepsin SAP1 (Candida albicans), Uniprot accession P0CY27 (peptidase unit: 43-380), MERNUM MER0002153
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.24
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Pharmaceutical relevance	Suggested to contribute to epithelial damage in vaginal candidiasis (Schaller et al., 2003).
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	L/V/E/lf-/Y/L/V (based on 26 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	1	0	0	0	0	1	1
Pro	2	0	0	0	0	0	1	1
Ala	1	2	0	1	1	2	1	0
Val	0	17	0	2	2	1	0	15
Leu	16	0	2	12	6	0	19	2
Ile	0	0	1	0	2	0	1	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	3	6	2	0	0	0
Tyr	0	0	0	1	2	15	0	1
Trp	0	0	0	0	1	0	0	0
Ser	1	1	0	0	0	0	0	0
Thr	0	0	0	0	1	1	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	1	0	0	0
Gln	0	0	0	0	1	1	0	0
Asp	1	1	1	0	1	0	0	0
Glu	0	0	15	0	2	1	0	0
Lys	1	0	1	2	0	0	0	1
Arg	1	1	1	1	0	3	0	0
His	0	1	1	1	0	0	1	0