Literature for peptidase A01.001: pepsin A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Yin,R., Liu,H., Song,Y., Kang,J., Shi,B. and Zeng,Y.
    Stabilization of acid proteases through interaction with polyvalent metal ions: Insights from classical leather tanning theory
    Int J Biol Macromol (2026) 348, 150749-150749. PubMed  Europe PubMed DOI
  2. 2025
  3. Borowitz,D.
    Non-Pancreatic Digestive Enzymes
    Biomolecules (2025) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Heda,R., Toro,F. and Tombazzi,C.R.
    Physiology, Pepsin
    (2025) PubMed  Europe PubMed
  5. Liu,Y., Chen,L., Huang,J., Zhang,J., Chen,S., Lin,Z. and Chen,T.
    A rapid and highly sensitive fluorescence immunochromatographic test strip for pepsin detection in human hypopharyngeal saliva
    Anal Methods (2025) PubMed  Europe PubMed DOI
  6. Roheen,T., Perveen,N., Assad,N., Rehman,M.F.U., Nadeem,M., Atif,F.A., Gondal,H.Y., Batool,F., Bibi,M., Shahzad, Bilal,A., Kousar,R., Zafar,N.U.A. and Gondal,D.
    Improved Destaining and Antimicrobial Potential of Pepsin Cross-linked HPMC-Se Nanoparticles
    IEEE Trans Nanobioscience (2025) PP PubMed  Europe PubMed DOI
  7. Samuels,T.L. and Johnston,N.
    Pepsin, Mucosal Injury, and Pathophysiology of Non-acid Reflux
    Otolaryngol Clin North Am (2025) PubMed  Europe PubMed DOI
  8. Shahraki,F.H., Shareghi,B. and Farhadian,S.
    Deciphering the molecular interaction between Vitamin D3 and pepsin by in vitro and in silico perspectives
    Spectrochim Acta A Mol Biomol Spectrosc (2025) 334, 125956-125956. PubMed  Europe PubMed DOI
  9. Yang,M., Yang,Z., Everett,D.W., Gilbert,E.P., Singh,H. and Ye,A.
    Digestion of food proteins: the role of pepsin
    Crit Rev Food Sci Nutr (2025) , 1-22. PubMed  Europe PubMed DOI  V
  10. Zhang,S., He,Z., Gao,L., Zhou,Z., Wang,Y., Li,X., Zheng,Y., Chi,B. and Tuo,X.
    Exploring the effects of food by-product HMF on pepsin structure, function, and physiological activity from a binding perspective
    Food Res Int (2025) 217, 116791-116791. PubMed  Europe PubMed DOI
  11. 2024
  12. Kabir,S., Hossain,M.A.A., Jahan,I., Ahmed,B., Malik,A., Goni,M.A., Hoque,M.A. and Anis-Ul-Haque,K.M.
    Exploration of the micellization behavior of sodium dodecyl sulfate in aqueous solution of gastric enzyme pepsin: Assessment of the consequences of sodium electrolytes and temperature
    Int J Biol Macromol (2024) 291, 138990-138990. PubMed  Europe PubMed DOI
  13. Li,J. and Allen,J.
    Salivary pepsin testing for laryngopharyngeal reflux: will it change our management?
    Curr Opin Otolaryngol Head Neck Surg (2024) 32, 398-402. PubMed  Europe PubMed DOI  V
  14. Santos,M.P.F., Junior,E.C.S., Bonomo,R.C.F., Santos,L.S. and Veloso,C.M.
    Hydrolysis of Casein by Pepsin Immobilized on Heterofunctional Supports to Produce Antioxidant Peptides
    Appl Biochem Biotechnol (2024) 196, 8605-8626. PubMed  Europe PubMed DOI
  15. Suwareh,O., Causeur,D., le Feunteun,S., Jardin,J., Briard-Bion,V., Pezennec,S. and Nau,F.
    Peptide bonds cleaved by pepsin are affected by the morphology of heat-induced ovalbumin aggregates
    Food Chem (2024) 458, 140260-140260. PubMed  Europe PubMed DOI
  16. Wang,C., Jiang,Y., Wu,Z., Wang,X., Yang,J., Li,J., Wei,S., Sun,G. and Wang,Z.
    A biosensor based on carbon dots-protein interactions for specific and sensitive detection of pepsin in saliva
    Int J Biol Macromol (2024) 281, 136665-136665. PubMed  Europe PubMed DOI
  17. 2023
  18. Akram,M., Osama,M., Hashmi,M.A. and Kabir,U.D.
    Molecular interaction of di-ester bonded cationic Gemini surfactants with pepsin: in vitro and in silico perspectives
    J Biomol Struct Dyn (2023) , 1-16. PubMed  Europe PubMed DOI
  19. Hashemi-Shahraki,F., Shareghi,B. and Farhadian,S.
    Investigation of the interaction behavior between quercetin and pepsin by spectroscopy and MD simulation methods
    Int J Biol Macromol (2023) 227, 1151-1161. PubMed  Europe PubMed DOI  I
  20. Hossain,M.A.A., Islam,T., Joy,M.T.R., Kowser,Z., Ahmed,M.Z., Rehman,M.T., Alajmi,M.F., Mahbub,S., Goni,M.A., Hoque,M.A. and Kabir,S.E.
    Interaction between gastric enzyme pepsin and tetradecyltrimethylammonium bromide in presence of sodium electrolytes: Exploration of micellization behavior
    Int J Biol Macromol (2023) 253, 127478-127478. PubMed  Europe PubMed DOI
  21. Jing,W., Luo,W. and Lou,L.
    Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis
    Braz J Otorhinolaryngol (2023) 89, 339-347. PubMed  Europe PubMed DOI
  22. Johnston,N., Samuels,T.L., Goetz,C.J., Arnold,L.A., Smith,B.C., Seabloom,D., Wuertz,B., Ondrey,F., Wiedmann,T.S., Vuksanovic,N., Silvaggi,N.R., Mackinnon,A.C., Miller,J., Bock,J. and Blumin,J.H.
    Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model
    Laryngoscope (2023) 133 Suppl 1, S1-S11. PubMed  Europe PubMed DOI  I
  23. Osman,M.M., El-Shaheny,R. and Ibrahim,F.A.
    Perception of the interaction behavior between pepsin and the antimicrobial drug secnidazole with combined experimental spectroscopy and computer-aided techniques
    Spectrochim Acta A Mol Biomol Spectrosc (2023) 291, 122336-122336. PubMed  Europe PubMed DOI
  24. Wang,X., Zhang,L., Yang,X. and Zhang,Q.
    3-Hydroxyflavone - bovine serum albumin complex used as fluorescent probe for the detection of pepsin
    Anal Biochem (2023) 662, 115003-115003. PubMed  Europe PubMed DOI
  25. 2022
  26. Iov,D.E., Barboi,O.B., Floria,M., Neamtu,A., Iliescu,R. and Drug,V.L.
    Pepsin and the Lung-Exploring the Relationship between Micro-Aspiration and Respiratory Manifestations of Gastroesophageal Reflux Disease
    J Pers Med (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
  27. Li,M., Wang,Y., He,K. and Wang,Y.
    Determination of pepsin by capillary electrophoresis using mixed polymer coated capillary with switchable properties toward protein adsorption/desorption
    J Sep Sci (2022) 45, 1960-1970. PubMed  Europe PubMed DOI
  28. Li,T.J., Wen,B.Y., Ma,X.H., Huang,W.T., Wu,J.Z., Lin,X.M., Zhang,Y.J. and Li,J.F.
    Rapid and Simple Analysis of the Human Pepsin Secondary Structure Using a Portable Raman Spectrometer
    Anal Chem (2022) 94, 1318-1324. PubMed  Europe PubMed DOI
  29. Morellon-Sterling,R., Tavano,O., Bolivar,J.M., Berenguer-Murcia,A., Vela-Gutierrez,G., Sabir,J.S.M., Tacias-Pascacio,V.G. and Fernandez-Lafuente,R.
    A review on the immobilization of pepsin: A Lys-poor enzyme that is unstable at alkaline pH values
    Int J Biol Macromol (2022) 210, 682-702. PubMed  Europe PubMed DOI
  30. Yu,L., Li,R., Du,L. and Zhao,Y.
    The diagnostic value of pepsin concentration in saliva for laryngopharyngeal reflux disease
    Eur Arch Otorhinolaryngol (2022) PubMed  Europe PubMed DOI
  31. 2021
  32. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
    Biol Chem (2021) 402, 861-867. PubMed  Europe PubMed DOI
  33. Grahame,D.A.S., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    Improving the alkaline stability of pepsin through rational protein design using renin, an alkaline-stable aspartic protease, as a structural and functional reference
    Enzyme Microb Technol (2021) 150, 109871-109871. PubMed  Europe PubMed DOI
  34. Rao,Y.F., Wang,J., Cheng,D.N., Xu,Y., Ren,X., Yang,W., Liu,G., Xu,W., Yan,X.H., Song,Y., Zheng,Y.B., An,P., Zhong,D.L., He,Z.P., Ren,J.J. and Zhao,Y.
    The Controversy of Pepsinogen A/Pepsin A in Detecting Extra-Gastroesophageal Reflux
    J Voice (2021) PubMed  Europe PubMed DOI
  35. Rivera Del Rio,A., Keppler,J.K., Boom,R.M. and Janssen,A.E.M.
    Protein acidification and hydrolysis by pepsin ensure efficient trypsin-catalyzed hydrolysis
    Food Funct (2021) 12, 4570-4581. PubMed  Europe PubMed DOI
  36. Suwareh,O., Causeur,D., Jardin,J., Briard-Bion,V., le Feunteun,S., Pezennec,S. and Nau,F.
    Statistical modeling of in vitro pepsin specificity
    Food Chem (2021) 362, 130098-130098. PubMed  Europe PubMed DOI
  37. Yadlapati,R., Kaizer,A., Greytak,M., Ezekewe,E., Simon,V. and Wani,S.
    Diagnostic performance of salivary pepsin for gastroesophageal reflux disease
    Dis Esophagus (2021) 34, doaa117-doaa117. PubMed  Europe PubMed DOI
  38. Yin,C.Y., Zhang,S.S., Zhong,J.T. and Zhou,S.H.
    Pepsin and laryngeal and hypopharyngeal carcinomas
    Clin Exp Otorhinolaryngol (2021) 14, 159-168. PubMed  Europe PubMed DOI  V
  39. 2020
  40. Chen,Y.L., Bao,Y.Y., Zhou,S.H., Yao,H.T. and Chen,Z.
    Relationship Between Pepsin Expression and Dysplasia Grade in Patients With Vocal Cord Leukoplakia
    Otolaryngol Head Neck Surg (2020) , 194599820938654-194599820938654. PubMed  Europe PubMed DOI
  41. Choi,Y.S., Na,H.G., Bae,C.H., Song,S.Y. and Kim,Y.D.
    Pepsin exposure in a non-acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)/nuclear factor kappaB (NF-kappaB) in human airway epithelial cells
    Int Forum Allergy Rhinol (2020) PubMed  Europe PubMed DOI  K  L
  42. Fang,M., Xiong,S., Jiang,Y., Yin,T., Hu,Y., Liu,R. and You,J.
    In Vitro Pepsin Digestion Characteristics of Silver Carp (Hypophthalmichthys molitrix) Surimi Gels with Different Degrees of Cross-Linking Induced by Setting Time and Microbial Transglutaminase
    J Agric Food Chem (2020) 68, 8413-8430. PubMed  Europe PubMed DOI
  43. Gao,X., Liu,D.G., Wang,F., Zhang,C., Du,X., Wu,J.M., Wang,Z.G. and Li,F.
    Efficacy evaluation of pepsin in laparoscopic antireflux surgery for gastroesophageal reflux disease
    Technol Health Care (2020) PubMed  Europe PubMed DOI
  44. Grahame,D.S.A., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    Comparative bioinformatic and structural analyses of pepsin and renin
    Enzyme Microb Technol (2020) 141, 109632-109632. PubMed  Europe PubMed DOI
  45. Kolinski,M., Kmiecik,S., Dec,R., Piejko,M., Mak,P. and Dzwolak,W.
    Docking interactions determine early cleavage events in insulin proteolysis by pepsin: experiment and simulation
    Int J Biol Macromol (2020) 149, 1151-1160. PubMed  Europe PubMed DOI  P
  46. Lee,T.H.
    Can We Apply the Salivary Pepsin Test for Patients With Gastroesophageal Reflux Disease in Primary Practice?
    J Neurogastroenterol Motil (2020) 26, 417-418. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Magliulo,G., Pace,A., Plateroti,A., Plateroti,A.M., Cascella,R., Solito,C., Rossetti,V. and Iannella,G.
    Laryngopharyngeal reflux disease in adult patients: tears and pepsin
    J Biol Regul Homeost Agents (2020) 34, 715-720. PubMed  Europe PubMed DOI
  48. Moradi,S., Gholami,H., Karami,C., Farhadian,N., Balaei,F., Ansari,M. and Shahlaei,M.
    A study on the protease activity and structure of pepsin in the presence of atenolol and diltiazem
    Int J Biol Macromol (2020) PubMed  Europe PubMed DOI
  49. Mullahoo,J., Zhang,T., Clauser,K., Carr,S.A., Jaffe,J.D. and Papanastasiou,M.
    Dual protease type XIII/pepsin digestion offers superior resolution and overlap for the analysis of histone tails by HX-MS
    Methods (2020) PubMed  Europe PubMed DOI
  50. Plateroti,R., Sacchetti,M., Magliulo,G., Plateroti,A.M., Pace,A., Moramarco,A., Lambiase,A. and Bruscolini,A.
    Evidence of Pepsin-Related Ocular Surface Damage and Dry Eye (PROD Syndrome) in Patients with Laryngopharyngeal Reflux
    Life (Basel) (2020) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  51. Samuels,T.L. and Johnston,N.
    Pepsin in gastroesophageal and extraesophageal reflux: molecular pathophysiology and diagnostic utility
    Curr Opin Otolaryngol Head Neck Surg (2020) 28, 401-409. PubMed  Europe PubMed DOI  V
  52. Shinu,P., Singh,V.A., Nair,A., Venugopala,K.N. and Akrawi,S.H.
    Papain-cetylpyridinium chloride and pepsin-cetylpyridinium chloride; two novel, highly sensitive, concentration, digestion and decontamination techniques for culturing mycobacteria from clinically suspected pulmonary tuberculosis cases
    PLoS ONE (2020) 15, e0236700-e0236700. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Zhang,M., Chia,C., Stanley,C., Phyland,D.J. and Paddle,P.M.
    Diagnostic Utility of Salivary Pepsin as Compared With 24-Hour Dual pH/Impedance Probe in Laryngopharyngeal Reflux
    Otolaryngol Head Neck Surg (2020) , 194599820951183-194599820951183. PubMed  Europe PubMed DOI
  54. Zheng,J., Strutzenberg,T.S., Reich,A., Dharmarajan,V., Pascal,B.D., Crynen,G.C., Novick,S.J., Garcia-Ordonez,R.D. and Griffin,P.R.
    Comparative analysis of cleavage specificities of immobilized porcine pepsin and Nepenthesin II under HDX conditions
    Anal Chem (2020) 92, 11018-11028. PubMed  Europe PubMed DOI
  55. 2019
  56. Ahsan,M. and Senapati,S.
    Water plays a cocatalytic role in epoxide ring opening reaction in aspartate proteases: a QM/MM study
    J Phys Chem B (2019) 123, 7955-7964. PubMed  Europe PubMed DOI
  57. Lian,S.Q., Lian,J., Wang,G.R., Li,L., Yang,D.Z. and Xue,Y.S.
    Investigation of binding between fluoroquinolones and pepsin by fluorescence spectroscopy and molecular simulation
    Luminescence (2019) 34, 595-601. PubMed  Europe PubMed DOI
  58. Shi,Y., Liu,M., Yan,H., Cai,C., Guo,Q., Pei,W., Zhang,R., Wang,Z. and Han,J.
    Mutual influence of piceatannol and bisphenol F on their interaction with pepsin: Insights from spectroscopic, isothermal titration calorimetry and molecular modeling studies
    Spectrochim Acta A Mol Biomol Spectrosc (2019) 206, 384-395. PubMed  Europe PubMed DOI  I
  59. 2018
  60. Li,C., Huang,Z., Dong,L. and Liu,X.
    Improvement of enzymological properties of pepsin by chemical modification with chitooligosaccharides
    Int J Biol Macromol (2018) 118, 216-227. PubMed  Europe PubMed DOI
  61. Luo,Q., Chen,D., Boom,R.M. and Janssen,A.E.M.
    Revisiting the enzymatic kinetics of pepsin using isothermal titration calorimetry
    Food Chem (2018) 268, 94-100. PubMed  Europe PubMed DOI
  62. Mat,D.J.L., Cattenoz,T., Souchon,I., Michon,C. and le Feunteun,S.
    Monitoring protein hydrolysis by pepsin using pH-stat: In vitro gastric digestions in static and dynamic pH conditions
    Food Chem (2018) 239, 268-275. PubMed  Europe PubMed DOI  A
  63. Mohseni-Shahri,F.S., Moeinpour,F. and Nosrati,M.
    Spectroscopy and molecular dynamics simulation study on the interaction of sunset yellow food additive with pepsin
    Int J Biol Macromol (2018) 115, 273-280. PubMed  Europe PubMed DOI
  64. Petersen,K.U.
    Pepsin and its importance for functional dyspepsia: relic, regulator or remedy?
    Dig Dis (2018) 36, 98-105. PubMed  Europe PubMed DOI
  65. Sams,L., Amara,S., Mansuelle,P., Puppo,R., Lebrun,R., Paume,J., Giallo,J. and Carriere,F.
    Characterization of pepsin from rabbit gastric extract, its action on beta-casein and the effects of lipids on proteolysis
    Food Funct (2018) 9, 5975-5988. PubMed  Europe PubMed DOI
  66. 2017
  67. Qian,J., Ito,S., Satoh,J., Geng,H., Tanaka,K., Hattori,S., Kojima,K., Takita,T. and Yasukawa,K.
    The cleavage site preference of the porcine pepsin on the N-terminal alpha1 chain of bovine type I collagen: a focal analysis with mass spectrometry
    Biosci Biotechnol Biochem (2017) 81, 514-522. PubMed  Europe PubMed DOI  P
  68. Rastegari,A.A., Buzari,B. and Bordbar,A.-K.
    Thermal stability of pepsin: a predictive thermodynamic model of a multi-domain protein
    Biochem Biophys Rep (2017) 9, 295-301. PubMed  Europe PubMed DOI
  69. Tonda,A., Grosvenor,A., Clerens,S. and le Feunteun,S.
    In silico modeling of protein hydrolysis by endoproteases: a case study on pepsin digestion of bovine lactoferrin
    Food Funct (2017) 8, 4404-4413. PubMed  Europe PubMed DOI  P
  70. Xie,Z., Zhang,S., Jiang,G., Liang,M. and Le,Z.
    Pepsin-catalyzed synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives
    Chin J Org Chem (2017) 37, 514-519. DOI
  71. 2016
  72. Holdrich,M., Sievers-Engler,A. and Lammerhofer,M.
    Gold nanoparticle-conjugated pepsin for efficient solution-like heterogeneous biocatalysis in analytical sample preparation protocols
    Anal Bioanal Chem (2016) 408, 5415-5427. PubMed  Europe PubMed DOI
  73. Jones,R.G. and Martino,A.
    Linear models of ovine IgG1 and IgG2 subclasses and predicted pepsin cleavage sites
    J Pharm Biomed Anal (2016) 117, 150-154. PubMed  Europe PubMed DOI
  74. Liu,Y., Zhang,Y., Guo,H., Wu,W., Dong,P. and Liang,X.
    Accelerated digestion of nucleic acids by pepsin from the stomach of chicken
    Br Poult Sci (2016) 57, 674-681. PubMed  Europe PubMed DOI
  75. Long,Y., Cao,B., Wang,Y. and Luo,D.
    Pepsin is a positive regulator of Ac-cathB-2 involved in the rat gut penetration of Angiostrongylus cantonensis
    Parasit Vectors (2016) 9, 286-286. PubMed  Europe PubMed DOI  PMC  EPMC
  76. Nagasawa,T., Sano,K., Kawaguchi,M., Kobayashi,K., Yasumasu,S. and Inokuchi,T.
    Purification and molecular cloning of aspartic proteinases from the stomach of adult Japanese fire belly newts, Cynops pyrrhogaster
    J Biochem (2016) 159, 449-460. PubMed  Europe PubMed DOI
  77. Xiang,Y., Song,J., Zhang,Y., Yang,D.C., Guan,Z. and He,Y.H.
    Enzyme-catalyzed asymmetric domino thia-Michael/aldol condensation using pepsin
    J Org Chem (2016) 81, 6042-6048. PubMed  Europe PubMed DOI
  78. Xue,J.-W., Song,J., Manion,I.C.K., He,Y.-H. and Guan,Z.
    Asymmetric Morita-Baylis-Hillman reaction catalyzed by pepsin
    J Mol Catal B Enzym (2016) 124, 62-69. DOI
  79. Zhang,Y., Li,C., Liu,Y., Wang,X., Dong,P. and Liang,X.
    Mechanism of extraordinary DNA digestion by pepsin
    Biochem Biophys Res Commun (2016) 472, 101-107. PubMed  Europe PubMed DOI  P
  80. Zhang,Y., Liu,Y., Guo,H., Jiang,W., Dong,P. and Liang,X.
    Site-directed mutagenesis of porcine pepsin: possible role of Asp32, Thr33, Asp215 and Gly217 in maintaining the nuclease activity of pepsin
    Enzyme Microb Technol (2016) 89, 69-75. PubMed  Europe PubMed DOI
  81. 2015
  82. Fang,Y., Xu,H., Shen,L., Huang,F., Yibulayin,S., Huang,S., Tian,S., Hu,Z., He,Z., Li,F., Li,Y. and Zhou,K.
    Study on the mechanism of the interaction between acteoside and pepsin using spectroscopic techniques
    Luminescence (2015) 30, 859-866. PubMed  Europe PubMed DOI  I
  83. Li,L.-Y., Yang,D.-C., Guan,Z. and He,Y.-H.
    Pepsin-catalyzed direct asymmetric aldol reactions for the synthesis of vicinal diol compounds
    Tetrahedron (2015) 71, 1679-1667. DOI
  84. Mysore,S.S. and Rudrapatnam,T.N.
    Modulation in the rheological behaviour of porcine pepsin treated guar galactomannan on admixture with kappa-carrageenan
    Carbohydr Polym (2015) 115, 253-259. PubMed  Europe PubMed DOI
  85. Piejko,M., Dec,R., Babenko,V., Hoang,A., Szewczyk,M., Mak,P. and Dzwolak,W.
    Highly amyloidogenic two-chain peptide fragments are released upon partial digestion of insulin with pepsin
    J Biol Chem (2015) 290, 5947-5958. PubMed  Europe PubMed DOI
  86. Samuels,T., Hoekzema,C., Gould,J., Goldblatt,M., Frelich,M., Bosler,M., Lee,S.H. and Johnston,N.
    Local synthesis of pepsin in Barrett's esophagus and the role of pepsin in esophageal adenocarcinoma
    Ann Otol Rhinol Laryngol (2015) 124, 893-902. PubMed  Europe PubMed DOI
  87. Wang,Y.Q. and Zhang,H.M.
    Exploration of binding of C.I. Food Red 9 with pepsin by optical spectroscopic and molecular docking methods
    Spectrochim Acta A Mol Biomol Spectrosc (2015) 149, 822-829. PubMed  Europe PubMed DOI
  88. Ying,M., Huang,F., Ye,H., Xu,H., Shen,L., Huan,T., Huang,S., Xie,J., Tian,S., Hu,Z., He,Z., Lu,J. and Zhou,K.
    Study on interaction between curcumin and pepsin by spectroscopic and docking methods
    Int J Biol Macromol (2015) 79, 201-208. PubMed  Europe PubMed DOI  I
  89. Zeng,H.J., Yang,R., Liang,H. and Qu,L.B.
    Molecular interactions of flavonoids to pepsin: insights from spectroscopic and molecular docking studies
    Spectrochim Acta A Mol Biomol Spectrosc (2015) 151, 576-590. PubMed  Europe PubMed DOI  I
  90. 2014
  91. Horimoto,Y., Wang,S. and Yada,R.Y.
    1H, 13C, and 15N backbone resonance assignments of the porcine pepsin and porcine pepsin complexed with pepstatin
    Biomol NMR Assign (2014) 8, 57-61. PubMed  Europe PubMed DOI  S  I
  92. Meridor,D. and Gedanken,A.
    Enhanced activity of immobilized pepsin nanoparticles coated on solid substrates compared to free pepsin
    Enzyme Microb Technol (2014) 67, 67-76. PubMed  Europe PubMed DOI
  93. Shobha,M.S., Gowda,L.R. and Tharanathan,R.N.
    A novel catalysis by porcine pepsin in debranching guar galactomannan
    Carbohydr Polym (2014) 102, 615-621. PubMed  Europe PubMed DOI
  94. Sun,Y., Takada,K., Nogi,Y., Okada,S. and Matsunaga,S.
    Lower homologues of ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp
    J Nat Prod (2014) 77, 1749-1752. PubMed  Europe PubMed DOI  I
  95. Sviridenko,U.Y., Abramov,D.V., Murunova,G.V. and Osipov,N.N.
    Application of membrane technology to liquid pepsin extract processing
    Pet Chem (2014) 54, 710-713. DOI
  96. Zeng,H.J., You,J., Liang,H.L., Qi,T., Yang,R. and Qu,L.B.
    Investigation on the binding interaction between silybin and pepsin by spectral and molecular docking
    Int J Biol Macromol (2014) 67, 105-111. PubMed  Europe PubMed DOI  I
  97. Zeng,H.J., Liang,H.L., You,J. and Qu,L.B.
    Study on the binding of chlorogenic acid to pepsin by spectral and molecular docking
    Luminescence (2014) 29, 715-721. PubMed  Europe PubMed DOI  I
  98. 2013
  99. Ahn,J., Cao,M.J., Yu,Y.Q. and Engen,J.R.
    Accessing the reproducibility and specificity of pepsin and other aspartic proteases
    Biochim Biophys Acta (2013) 1834, 1222-1229. PubMed  Europe PubMed DOI  P
  100. Naicker,P., Seele,P., Dirr,H.W. and Sayed,Y.
    F99 is critical for dimerization and activation of South African HIV-1 subtype C protease
    Protein J (2013) 32, 560-567. PubMed  Europe PubMed DOI  I
  101. 2012
  102. Bailey,D., Carpenter,E.P., Coker,A., Coker,S., Read,J., Jones,A.T., Erskine,P., Aguilar,C.F., Badasso,M., Toldo,L., Rippmann,F., Sanz-Aparicio,J., Albert,A., Blundell,T.L., Roberts,N.B., Wood,S.P. and Cooper,J.B.
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    Some observations on the conversion of three different human pepsinogens to their respective pepsins
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    Partial characterization of human pepsin I, pepsin IIA, pepsin IIB, and pepsin III
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  352. Tang,J.
    SPECIFICITY OF PEPSIN AND ITS DEPENDENCE ON A POSSIBLE 'HYDROPHOBIC BINDING SITE'
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  354. Herriott,R.M.
    Pepsinogen and pepsin
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  356. Taylor,W.H.
    Studies on gastric proteolysis. 1. The proteolytic activity of human gastric juice and pig and calf gastric mucosal extracts below pH 5
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    Structural changes associated with the conversion of pepsinogen to pepsin. II. The N-terminal amino acid residues of pepsin and pepsinogen; The amino acid composition of pepsinogen
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    Action of pepsin on synthetic substrates [7]
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    The active groups of pepsin
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  364. Herriott,R.M.
    [1] Swine pepsin and pepsinogen
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  366. Baker,L.E.
    New synthetic substrates for pepsin
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    Amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates
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    Crystallization of pepsin from alcohol
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    Fractionation of pepsin: 1. Isolation of crystalline pepsin of constant activity and solubility from pepsinogen or commercial pepsin preparations. 2. Preparation of a less soluble fraction. 3. Solubility curves of mixtures of the soluble and insoluble fractions. 4. Preparation of highly active pepsin from pepsinogen
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    Electrophoresis of pepsin
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    The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin
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  376. 1938
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    TRANSFORMATION OF SWINE PEPSINOGEN INTO SWINE PEPSIN BY CHICKEN PEPSIN
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    Isolation, crystallization, and properties of swine pepsinogen
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  379. 1935
  380. Sherwood,I.R.
    122. The function of pepsin and rennet in the ripening of cheddar cheese
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  382. Bernal,J.D. and Crowfoot,d.
    X-ray photographs of crystalline pepsin [3]
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    Crystalline acetyl derivatives of pepsin
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    Crystalline pepsin: VI. Inactivation by beta and gamma rays from radium and by ultra-violet light
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  385. 1933
  386. Calvery,H.O.
    Crystalline egg albumin. The hydrolysis of crystalline egg albumin by pepsin, papain-hydrocyanic acid, and pancreatic proteinase and the subsequent action of some other enzymes on the hydrolysis products produced by these enzymes
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    Crystalline pepsin: V. Isolation of crystalline pepsin from bovine gastric juice
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    Pepsin activity units and methods for determining peptic activity
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    Crystalline pepsin: IV. Hydrolysis and inactivation by acid
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    Crystalline pepsin: III. Preparation of active crystalline pepsin from inactive denatured pepsin
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  394. Northrop,J.H.
    Crystalline pepsin. II. General properties and experimental methods
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    Crystalline pepsin. I. Isolation and tests of purity
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  397. Forbes,J.C.
    The purification of pepsin
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    Uber die Wirkungsweise des Pepsins: (Sechste Mitteilung zur Spezifitat tierischer Proteasen.)
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    A test for diffusible ions: II. The ionic nature of pepsin
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    Bereitung von Standards zur colorimetrischen Bestimmung des Pepsins
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  404. Hammarsten,O.
    Studien Uber Chymosin- und Pepsinwirkung. IX. Mitteilung. Uber das Verschiedene verhalten der Magenenzyme von Kalb und Schwein gegen Saurewirkung beim Erwarmen
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    A method for the quantitative determination of trypsin and pepsin
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    The influence of the substrate concentration on the rate of hydrolysis of proteins by pepsin
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    The influence of hydrogen ion concentration on the inactivation of pepsin solutions
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    The effect of the concentration of enzyme on the rate of digestion of proteins by pepsin
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    The significance of the hydrogen ion concentration for the digestion of proteins by pepsin
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  412. Davis,L. and Merker,H.M.
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    The combination of enzyme and substrate: I. A method for the quantitative determination of pepsin. II. The effect of the hydrogen ion concentration
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  416. Hammarsten,O.
    Studien uber Chymosin- und Pepsinwirkung: IV. Mitteilung. Die Wirkung der Enzyme auf Natriumcaseinate
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  419. Hamburger,W.W. and Halpern,B.
    Further studies in the inactivation of pepsin: the effects of various salts and alkaline substances
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  421. Porter,A.E.
    On the question of the identity of pepsin and rennet
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  423. Rose,W.C.
    A modified method for the clinical estimation of pepsin
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  425. Sawjalow,W.
    Zur Frage nach der Identitat von Pepsin und Chymosin
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