Literature for peptidase A01.001: pepsin A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Heda,R., Toro,F. and Tombazzi,C.R.
    Physiology, Pepsin
    PubMed  Europe PubMed
  2. Liu,Y., Chen,L., Huang,J., Zhang,J., Chen,S., Lin,Z. and Chen,T.
    A rapid and highly sensitive fluorescence immunochromatographic test strip for pepsin detection in human hypopharyngeal saliva
    Anal Methods PubMed  Europe PubMed DOI
  3. Samuels,T.L. and Johnston,N.
    Pepsin, Mucosal Injury, and Pathophysiology of Non-acid Reflux
    Otolaryngol Clin North Am PubMed  Europe PubMed DOI
  4. Shahraki,F.H., Shareghi,B. and Farhadian,S.
    Deciphering the molecular interaction between Vitamin D3 and pepsin by in vitro and in silico perspectives
    Spectrochim Acta A Mol Biomol Spectrosc334, 125956-125956. PubMed  Europe PubMed DOI
  5. Yang,M., Yang,Z., Everett,D.W., Gilbert,E.P., Singh,H. and Ye,A.
    Digestion of food proteins: the role of pepsin
    Crit Rev Food Sci Nutr1-22. PubMed  Europe PubMed DOI  V
  6. 2024
  7. Kabir,S., Hossain,M.A.A., Jahan,I., Ahmed,B., Malik,A., Goni,M.A., Hoque,M.A. and Anis-Ul-Haque,K.M.
    Exploration of the micellization behavior of sodium dodecyl sulfate in aqueous solution of gastric enzyme pepsin: Assessment of the consequences of sodium electrolytes and temperature
    Int J Biol Macromol291, 138990-138990. PubMed  Europe PubMed DOI
  8. Li,J. and Allen,J.
    Salivary pepsin testing for laryngopharyngeal reflux: will it change our management?
    Curr Opin Otolaryngol Head Neck Surg32, 398-402. PubMed  Europe PubMed DOI  V
  9. Santos,M.P.F., Junior,E.C.S., Bonomo,R.C.F., Santos,L.S. and Veloso,C.M.
    Hydrolysis of Casein by Pepsin Immobilized on Heterofunctional Supports to Produce Antioxidant Peptides
    Appl Biochem Biotechnol196, 8605-8626. PubMed  Europe PubMed DOI
  10. Suwareh,O., Causeur,D., le Feunteun,S., Jardin,J., Briard-Bion,V., Pezennec,S. and Nau,F.
    Peptide bonds cleaved by pepsin are affected by the morphology of heat-induced ovalbumin aggregates
    Food Chem458, 140260-140260. PubMed  Europe PubMed DOI
  11. Wang,C., Jiang,Y., Wu,Z., Wang,X., Yang,J., Li,J., Wei,S., Sun,G. and Wang,Z.
    A biosensor based on carbon dots-protein interactions for specific and sensitive detection of pepsin in saliva
    Int J Biol Macromol281, 136665-136665. PubMed  Europe PubMed DOI
  12. 2023
  13. Akram,M., Osama,M., Hashmi,M.A. and Kabir,U.D.
    Molecular interaction of di-ester bonded cationic Gemini surfactants with pepsin: in vitro and in silico perspectives
    J Biomol Struct Dyn1-16. PubMed  Europe PubMed DOI
  14. Hashemi-Shahraki,F., Shareghi,B. and Farhadian,S.
    Investigation of the interaction behavior between quercetin and pepsin by spectroscopy and MD simulation methods
    Int J Biol Macromol227, 1151-1161. PubMed  Europe PubMed DOI  I
  15. Hossain,M.A.A., Islam,T., Joy,M.T.R., Kowser,Z., Ahmed,M.Z., Rehman,M.T., Alajmi,M.F., Mahbub,S., Goni,M.A., Hoque,M.A. and Kabir,S.E.
    Interaction between gastric enzyme pepsin and tetradecyltrimethylammonium bromide in presence of sodium electrolytes: Exploration of micellization behavior
    Int J Biol Macromol253, 127478-127478. PubMed  Europe PubMed DOI
  16. Jing,W., Luo,W. and Lou,L.
    Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis
    Braz J Otorhinolaryngol89, 339-347. PubMed  Europe PubMed DOI
  17. Johnston,N., Samuels,T.L., Goetz,C.J., Arnold,L.A., Smith,B.C., Seabloom,D., Wuertz,B., Ondrey,F., Wiedmann,T.S., Vuksanovic,N., Silvaggi,N.R., Mackinnon,A.C., Miller,J., Bock,J. and Blumin,J.H.
    Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model
    Laryngoscope133 Suppl 1, S1-S11. PubMed  Europe PubMed DOI  I
  18. Osman,M.M., El-Shaheny,R. and Ibrahim,F.A.
    Perception of the interaction behavior between pepsin and the antimicrobial drug secnidazole with combined experimental spectroscopy and computer-aided techniques
    Spectrochim Acta A Mol Biomol Spectrosc291, 122336-122336. PubMed  Europe PubMed DOI
  19. Wang,X., Zhang,L., Yang,X. and Zhang,Q.
    3-Hydroxyflavone - bovine serum albumin complex used as fluorescent probe for the detection of pepsin
    Anal Biochem662, 115003-115003. PubMed  Europe PubMed DOI
  20. 2022
  21. Iov,D.E., Barboi,O.B., Floria,M., Neamtu,A., Iliescu,R. and Drug,V.L.
    Pepsin and the Lung-Exploring the Relationship between Micro-Aspiration and Respiratory Manifestations of Gastroesophageal Reflux Disease
    J Pers Med12, PubMed  Europe PubMed DOI  V
  22. Li,M., Wang,Y., He,K. and Wang,Y.
    Determination of pepsin by capillary electrophoresis using mixed polymer coated capillary with switchable properties toward protein adsorption/desorption
    J Sep Sci45, 1960-1970. PubMed  Europe PubMed DOI
  23. Li,T.J., Wen,B.Y., Ma,X.H., Huang,W.T., Wu,J.Z., Lin,X.M., Zhang,Y.J. and Li,J.F.
    Rapid and Simple Analysis of the Human Pepsin Secondary Structure Using a Portable Raman Spectrometer
    Anal Chem94, 1318-1324. PubMed  Europe PubMed DOI
  24. Morellon-Sterling,R., Tavano,O., Bolivar,J.M., Berenguer-Murcia,A., Vela-Gutierrez,G., Sabir,J.S.M., Tacias-Pascacio,V.G. and Fernandez-Lafuente,R.
    A review on the immobilization of pepsin: A Lys-poor enzyme that is unstable at alkaline pH values
    Int J Biol Macromol210, 682-702. PubMed  Europe PubMed DOI
  25. Yu,L., Li,R., Du,L. and Zhao,Y.
    The diagnostic value of pepsin concentration in saliva for laryngopharyngeal reflux disease
    Eur Arch Otorhinolaryngol PubMed  Europe PubMed DOI
  26. 2021
  27. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
    Biol Chem402, 861-867. PubMed  Europe PubMed DOI
  28. Grahame,D.A.S., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    Improving the alkaline stability of pepsin through rational protein design using renin, an alkaline-stable aspartic protease, as a structural and functional reference
    Enzyme Microb Technol150, 109871-109871. PubMed  Europe PubMed DOI
  29. Rao,Y.F., Wang,J., Cheng,D.N., Xu,Y., Ren,X., Yang,W., Liu,G., Xu,W., Yan,X.H., Song,Y., Zheng,Y.B., An,P., Zhong,D.L., He,Z.P., Ren,J.J. and Zhao,Y.
    The Controversy of Pepsinogen A/Pepsin A in Detecting Extra-Gastroesophageal Reflux
    J Voice PubMed  Europe PubMed DOI
  30. Rivera Del Rio,A., Keppler,J.K., Boom,R.M. and Janssen,A.E.M.
    Protein acidification and hydrolysis by pepsin ensure efficient trypsin-catalyzed hydrolysis
    Food Funct12, 4570-4581. PubMed  Europe PubMed DOI
  31. Suwareh,O., Causeur,D., Jardin,J., Briard-Bion,V., le Feunteun,S., Pezennec,S. and Nau,F.
    Statistical modeling of in vitro pepsin specificity
    Food Chem362, 130098-130098. PubMed  Europe PubMed DOI
  32. Yadlapati,R., Kaizer,A., Greytak,M., Ezekewe,E., Simon,V. and Wani,S.
    Diagnostic performance of salivary pepsin for gastroesophageal reflux disease
    Dis Esophagus34, doaa117-doaa117. PubMed  Europe PubMed DOI
  33. Yin,C.Y., Zhang,S.S., Zhong,J.T. and Zhou,S.H.
    Pepsin and laryngeal and hypopharyngeal carcinomas
    Clin Exp Otorhinolaryngol14, 159-168. PubMed  Europe PubMed DOI  V
  34. 2020
  35. Chen,Y.L., Bao,Y.Y., Zhou,S.H., Yao,H.T. and Chen,Z.
    Relationship Between Pepsin Expression and Dysplasia Grade in Patients With Vocal Cord Leukoplakia
    Otolaryngol Head Neck Surg194599820938654-194599820938654. PubMed  Europe PubMed DOI
  36. Choi,Y.S., Na,H.G., Bae,C.H., Song,S.Y. and Kim,Y.D.
    Pepsin exposure in a non-acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)/nuclear factor kappaB (NF-kappaB) in human airway epithelial cells
    Int Forum Allergy Rhinol PubMed  Europe PubMed DOI  K  L
  37. Fang,M., Xiong,S., Jiang,Y., Yin,T., Hu,Y., Liu,R. and You,J.
    In Vitro Pepsin Digestion Characteristics of Silver Carp (Hypophthalmichthys molitrix) Surimi Gels with Different Degrees of Cross-Linking Induced by Setting Time and Microbial Transglutaminase
    J Agric Food Chem68, 8413-8430. PubMed  Europe PubMed DOI
  38. Gao,X., Liu,D.G., Wang,F., Zhang,C., Du,X., Wu,J.M., Wang,Z.G. and Li,F.
    Efficacy evaluation of pepsin in laparoscopic antireflux surgery for gastroesophageal reflux disease
    Technol Health Care PubMed  Europe PubMed DOI
  39. Grahame,D.S.A., Dupuis,J.H., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    Comparative bioinformatic and structural analyses of pepsin and renin
    Enzyme Microb Technol141, 109632-109632. PubMed  Europe PubMed DOI
  40. Kolinski,M., Kmiecik,S., Dec,R., Piejko,M., Mak,P. and Dzwolak,W.
    Docking interactions determine early cleavage events in insulin proteolysis by pepsin: experiment and simulation
    Int J Biol Macromol149, 1151-1160. PubMed  Europe PubMed DOI  P
  41. Lee,T.H.
    Can We Apply the Salivary Pepsin Test for Patients With Gastroesophageal Reflux Disease in Primary Practice?
    J Neurogastroenterol Motil26, 417-418. PubMed  Europe PubMed DOI
  42. Magliulo,G., Pace,A., Plateroti,A., Plateroti,A.M., Cascella,R., Solito,C., Rossetti,V. and Iannella,G.
    Laryngopharyngeal reflux disease in adult patients: tears and pepsin
    J Biol Regul Homeost Agents34, 715-720. PubMed  Europe PubMed DOI
  43. Moradi,S., Gholami,H., Karami,C., Farhadian,N., Balaei,F., Ansari,M. and Shahlaei,M.
    A study on the protease activity and structure of pepsin in the presence of atenolol and diltiazem
    Int J Biol Macromol PubMed  Europe PubMed DOI
  44. Mullahoo,J., Zhang,T., Clauser,K., Carr,S.A., Jaffe,J.D. and Papanastasiou,M.
    Dual protease type XIII/pepsin digestion offers superior resolution and overlap for the analysis of histone tails by HX-MS
    Methods PubMed  Europe PubMed DOI
  45. Plateroti,R., Sacchetti,M., Magliulo,G., Plateroti,A.M., Pace,A., Moramarco,A., Lambiase,A. and Bruscolini,A.
    Evidence of Pepsin-Related Ocular Surface Damage and Dry Eye (PROD Syndrome) in Patients with Laryngopharyngeal Reflux
    Life (Basel)10, PubMed  Europe PubMed DOI
  46. Samuels,T.L. and Johnston,N.
    Pepsin in gastroesophageal and extraesophageal reflux: molecular pathophysiology and diagnostic utility
    Curr Opin Otolaryngol Head Neck Surg28, 401-409. PubMed  Europe PubMed DOI  V
  47. Shinu,P., Singh,V.A., Nair,A., Venugopala,K.N. and Akrawi,S.H.
    Papain-cetylpyridinium chloride and pepsin-cetylpyridinium chloride; two novel, highly sensitive, concentration, digestion and decontamination techniques for culturing mycobacteria from clinically suspected pulmonary tuberculosis cases
    PLoS ONE15, e0236700-e0236700. PubMed  Europe PubMed DOI
  48. Zhang,M., Chia,C., Stanley,C., Phyland,D.J. and Paddle,P.M.
    Diagnostic Utility of Salivary Pepsin as Compared With 24-Hour Dual pH/Impedance Probe in Laryngopharyngeal Reflux
    Otolaryngol Head Neck Surg194599820951183-194599820951183. PubMed  Europe PubMed DOI
  49. Zheng,J., Strutzenberg,T.S., Reich,A., Dharmarajan,V., Pascal,B.D., Crynen,G.C., Novick,S.J., Garcia-Ordonez,R.D. and Griffin,P.R.
    Comparative analysis of cleavage specificities of immobilized porcine pepsin and Nepenthesin II under HDX conditions
    Anal Chem92, 11018-11028. PubMed  Europe PubMed DOI
  50. 2019
  51. Ahsan,M. and Senapati,S.
    Water plays a cocatalytic role in epoxide ring opening reaction in aspartate proteases: a QM/MM study
    J Phys Chem B123, 7955-7964. PubMed  Europe PubMed DOI
  52. Lian,S.Q., Lian,J., Wang,G.R., Li,L., Yang,D.Z. and Xue,Y.S.
    Investigation of binding between fluoroquinolones and pepsin by fluorescence spectroscopy and molecular simulation
    Luminescence34, 595-601. PubMed  Europe PubMed DOI
  53. Shi,Y., Liu,M., Yan,H., Cai,C., Guo,Q., Pei,W., Zhang,R., Wang,Z. and Han,J.
    Mutual influence of piceatannol and bisphenol F on their interaction with pepsin: Insights from spectroscopic, isothermal titration calorimetry and molecular modeling studies
    Spectrochim Acta A Mol Biomol Spectrosc206, 384-395. PubMed  Europe PubMed DOI  I
  54. 2018
  55. Li,C., Huang,Z., Dong,L. and Liu,X.
    Improvement of enzymological properties of pepsin by chemical modification with chitooligosaccharides
    Int J Biol Macromol118, 216-227. PubMed  Europe PubMed DOI
  56. Luo,Q., Chen,D., Boom,R.M. and Janssen,A.E.M.
    Revisiting the enzymatic kinetics of pepsin using isothermal titration calorimetry
    Food Chem268, 94-100. PubMed  Europe PubMed DOI
  57. Mat,D.J.L., Cattenoz,T., Souchon,I., Michon,C. and le Feunteun,S.
    Monitoring protein hydrolysis by pepsin using pH-stat: In vitro gastric digestions in static and dynamic pH conditions
    Food Chem239, 268-275. PubMed  Europe PubMed DOI  A
  58. Mohseni-Shahri,F.S., Moeinpour,F. and Nosrati,M.
    Spectroscopy and molecular dynamics simulation study on the interaction of sunset yellow food additive with pepsin
    Int J Biol Macromol115, 273-280. PubMed  Europe PubMed DOI
  59. Petersen,K.U.
    Pepsin and its importance for functional dyspepsia: relic, regulator or remedy?
    Dig Dis36, 98-105. PubMed  Europe PubMed DOI
  60. Sams,L., Amara,S., Mansuelle,P., Puppo,R., Lebrun,R., Paume,J., Giallo,J. and Carriere,F.
    Characterization of pepsin from rabbit gastric extract, its action on beta-casein and the effects of lipids on proteolysis
    Food Funct9, 5975-5988. PubMed  Europe PubMed DOI
  61. 2017
  62. Qian,J., Ito,S., Satoh,J., Geng,H., Tanaka,K., Hattori,S., Kojima,K., Takita,T. and Yasukawa,K.
    The cleavage site preference of the porcine pepsin on the N-terminal alpha1 chain of bovine type I collagen: a focal analysis with mass spectrometry
    Biosci Biotechnol Biochem81, 514-522. PubMed  Europe PubMed DOI  P
  63. Rastegari,A.A., Buzari,B. and Bordbar,A.-K.
    Thermal stability of pepsin: a predictive thermodynamic model of a multi-domain protein
    Biochem Biophys Rep9, 295-301. PubMed  Europe PubMed DOI
  64. Tonda,A., Grosvenor,A., Clerens,S. and le Feunteun,S.
    In silico modeling of protein hydrolysis by endoproteases: a case study on pepsin digestion of bovine lactoferrin
    Food Funct8, 4404-4413. PubMed  Europe PubMed DOI  P
  65. Xie,Z., Zhang,S., Jiang,G., Liang,M. and Le,Z.
    Pepsin-catalyzed synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives
    Chin J Org Chem37, 514-519. DOI
  66. 2016
  67. Holdrich,M., Sievers-Engler,A. and Lammerhofer,M.
    Gold nanoparticle-conjugated pepsin for efficient solution-like heterogeneous biocatalysis in analytical sample preparation protocols
    Anal Bioanal Chem408, 5415-5427. PubMed  Europe PubMed DOI
  68. Jones,R.G. and Martino,A.
    Linear models of ovine IgG1 and IgG2 subclasses and predicted pepsin cleavage sites
    J Pharm Biomed Anal117, 150-154. PubMed  Europe PubMed DOI
  69. Liu,Y., Zhang,Y., Guo,H., Wu,W., Dong,P. and Liang,X.
    Accelerated digestion of nucleic acids by pepsin from the stomach of chicken
    Br Poult Sci57, 674-681. PubMed  Europe PubMed DOI
  70. Long,Y., Cao,B., Wang,Y. and Luo,D.
    Pepsin is a positive regulator of Ac-cathB-2 involved in the rat gut penetration of Angiostrongylus cantonensis
    Parasit Vectors9, 286-286. PubMed  Europe PubMed DOI
  71. Nagasawa,T., Sano,K., Kawaguchi,M., Kobayashi,K., Yasumasu,S. and Inokuchi,T.
    Purification and molecular cloning of aspartic proteinases from the stomach of adult Japanese fire belly newts, Cynops pyrrhogaster
    J Biochem159, 449-460. PubMed  Europe PubMed DOI
  72. Xiang,Y., Song,J., Zhang,Y., Yang,D.C., Guan,Z. and He,Y.H.
    Enzyme-catalyzed asymmetric domino thia-Michael/aldol condensation using pepsin
    J Org Chem81, 6042-6048. PubMed  Europe PubMed DOI
  73. Xue,J.-W., Song,J., Manion,I.C.K., He,Y.-H. and Guan,Z.
    Asymmetric Morita-Baylis-Hillman reaction catalyzed by pepsin
    J Mol Catal B Enzym124, 62-69. DOI
  74. Zhang,Y., Liu,Y., Guo,H., Jiang,W., Dong,P. and Liang,X.
    Site-directed mutagenesis of porcine pepsin: possible role of Asp32, Thr33, Asp215 and Gly217 in maintaining the nuclease activity of pepsin
    Enzyme Microb Technol89, 69-75. PubMed  Europe PubMed DOI
  75. Zhang,Y., Li,C., Liu,Y., Wang,X., Dong,P. and Liang,X.
    Mechanism of extraordinary DNA digestion by pepsin
    Biochem Biophys Res Commun472, 101-107. PubMed  Europe PubMed DOI  P
  76. 2015
  77. Fang,Y., Xu,H., Shen,L., Huang,F., Yibulayin,S., Huang,S., Tian,S., Hu,Z., He,Z., Li,F., Li,Y. and Zhou,K.
    Study on the mechanism of the interaction between acteoside and pepsin using spectroscopic techniques
    Luminescence30, 859-866. PubMed  Europe PubMed DOI  I
  78. Li,L.-Y., Yang,D.-C., Guan,Z. and He,Y.-H.
    Pepsin-catalyzed direct asymmetric aldol reactions for the synthesis of vicinal diol compounds
    Tetrahedron71, 1679-1667. DOI
  79. Mysore,S.S. and Rudrapatnam,T.N.
    Modulation in the rheological behaviour of porcine pepsin treated guar galactomannan on admixture with kappa-carrageenan
    Carbohydr Polym115, 253-259. PubMed  Europe PubMed DOI
  80. Piejko,M., Dec,R., Babenko,V., Hoang,A., Szewczyk,M., Mak,P. and Dzwolak,W.
    Highly amyloidogenic two-chain peptide fragments are released upon partial digestion of insulin with pepsin
    J Biol Chem290, 5947-5958. PubMed  Europe PubMed DOI
  81. Samuels,T., Hoekzema,C., Gould,J., Goldblatt,M., Frelich,M., Bosler,M., Lee,S.H. and Johnston,N.
    Local synthesis of pepsin in Barrett's esophagus and the role of pepsin in esophageal adenocarcinoma
    Ann Otol Rhinol Laryngol124, 893-902. PubMed  Europe PubMed DOI
  82. Wang,Y.Q. and Zhang,H.M.
    Exploration of binding of C.I. Food Red 9 with pepsin by optical spectroscopic and molecular docking methods
    Spectrochim Acta A Mol Biomol Spectrosc149, 822-829. PubMed  Europe PubMed DOI
  83. Ying,M., Huang,F., Ye,H., Xu,H., Shen,L., Huan,T., Huang,S., Xie,J., Tian,S., Hu,Z., He,Z., Lu,J. and Zhou,K.
    Study on interaction between curcumin and pepsin by spectroscopic and docking methods
    Int J Biol Macromol79, 201-208. PubMed  Europe PubMed DOI  I
  84. Zeng,H.J., Yang,R., Liang,H. and Qu,L.B.
    Molecular interactions of flavonoids to pepsin: insights from spectroscopic and molecular docking studies
    Spectrochim Acta A Mol Biomol Spectrosc151, 576-590. PubMed  Europe PubMed DOI  I
  85. 2014
  86. Horimoto,Y., Wang,S. and Yada,R.Y.
    1H, 13C, and 15N backbone resonance assignments of the porcine pepsin and porcine pepsin complexed with pepstatin
    Biomol NMR Assign8, 57-61. PubMed  Europe PubMed DOI  S  I
  87. Meridor,D. and Gedanken,A.
    Enhanced activity of immobilized pepsin nanoparticles coated on solid substrates compared to free pepsin
    Enzyme Microb Technol67, 67-76. PubMed  Europe PubMed DOI
  88. Shobha,M.S., Gowda,L.R. and Tharanathan,R.N.
    A novel catalysis by porcine pepsin in debranching guar galactomannan
    Carbohydr Polym102, 615-621. PubMed  Europe PubMed DOI
  89. Sun,Y., Takada,K., Nogi,Y., Okada,S. and Matsunaga,S.
    Lower homologues of ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp
    J Nat Prod77, 1749-1752. PubMed  Europe PubMed DOI  I
  90. Sviridenko,U.Y., Abramov,D.V., Murunova,G.V. and Osipov,N.N.
    Application of membrane technology to liquid pepsin extract processing
    Pet Chem54, 710-713. DOI
  91. Zeng,H.J., You,J., Liang,H.L., Qi,T., Yang,R. and Qu,L.B.
    Investigation on the binding interaction between silybin and pepsin by spectral and molecular docking
    Int J Biol Macromol67, 105-111. PubMed  Europe PubMed DOI  I
  92. Zeng,H.J., Liang,H.L., You,J. and Qu,L.B.
    Study on the binding of chlorogenic acid to pepsin by spectral and molecular docking
    Luminescence29, 715-721. PubMed  Europe PubMed DOI  I
  93. 2013
  94. Ahn,J., Cao,M.J., Yu,Y.Q. and Engen,J.R.
    Accessing the reproducibility and specificity of pepsin and other aspartic proteases
    Biochim Biophys Acta1834, 1222-1229. PubMed  Europe PubMed DOI  P
  95. Naicker,P., Seele,P., Dirr,H.W. and Sayed,Y.
    F99 is critical for dimerization and activation of South African HIV-1 subtype C protease
    Protein J32, 560-567. PubMed  Europe PubMed DOI  I
  96. 2012
  97. Bailey,D., Carpenter,E.P., Coker,A., Coker,S., Read,J., Jones,A.T., Erskine,P., Aguilar,C.F., Badasso,M., Toldo,L., Rippmann,F., Sanz-Aparicio,J., Albert,A., Blundell,T.L., Roberts,N.B., Wood,S.P. and Cooper,J.B.
    An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases
    Acta Crystallogr D Biol Crystallogr68, 541-552. PubMed  Europe PubMed DOI  S
  98. Dee,D.R. and Yada,R.Y.
    Neutron scattering and the folding and dynamics of the digestive enzyme pepsin
    Neutron News23, 29-32. DOI
  99. Khan,M.S., Akhtar,S., Siddiqui,S.A., Siddiqui,M.S., Srinivasan,K.V. and Arif,J.M.
    Design, synthesis and evaluation of unique 2,4,5-triaryl imidazole derivatives as novel potent aspartic protease inhibitors
    Med Chem8, 428-435. PubMed  Europe PubMed  I
  100. Tang,J.
    Pepsin A
    [ISSN:978-0-12-407744-7]3, 27-35. DOI
  101. 2011
  102. Dee,D.R., Myers,B. and Yada,R.Y.
    Dynamics of thermodynamically stable, kinetically trapped, and inhibitor-bound states of pepsin
    Biophys J101, 1699-1709. PubMed  Europe PubMed DOI
  103. 2010
  104. Dee,D.R. and Yada,R.Y.
    The prosegment catalyzes pepsin folding to a kinetically trapped native state
    Biochemistry49, 365-371. PubMed  Europe PubMed DOI
  105. Kageyama,H., Ueda,H., Tezuka,T., Ogasawara,A., Narita,Y., Kageyama,T. and Ichinose,M.
    Differences in the P1' substrate specificities of pepsin A and chymosin
    J Biochem147, 167-174. PubMed  Europe PubMed DOI  P
  106. Li,C., Zhou,Y.J., Wang,N., Feng,X.W., Li,K. and Yu,X.Q.
    Promiscuous protease-catalyzed aldol reactions: a facile biocatalytic protocol for carbon-carbon bond formation in aqueous media
    J Biotechnol150, 539-545. PubMed  Europe PubMed DOI
  107. Nalinanon,S., Benjakul,S. and Kishimura,H.
    Purification and biochemical properties of pepsins from the stomach of skipjack tuna (Katsuwonus pelamis)
    Eur Food Res Technol231, 259-269. DOI
  108. 2009
  109. Cardoso,T., Oliveira,C., Sarmento,A.C., Pereira,A., Nutley,M.A., Jess,T., Kelly,S.M., Cooper,A., Price,N.C., Pires,E. and Barros,M.
    Acetonitrile-induced unfolding of porcine pepsin A: a proposal for a critical role of hydration structures in conformational stability
    Int J Biol Macromol45, 213-220. PubMed  Europe PubMed DOI
  110. Dee,D.R., Filonowicz,S., Horimoto,Y. and Yada,R.Y.
    Recombinant prosegment peptide acts as a folding catalyst and inhibitor of native pepsin
    Biochim Biophys Acta1794, 1795-1801. PubMed  Europe PubMed DOI  E
  111. Filuszova,M., Kucerova,Z. and Ticha,M.
    Peptide inhibitor modified magnetic particles for pepsin separation
    J Sep Sci32, 2017-2021. PubMed  Europe PubMed DOI  I
  112. Kamangar,F., Diaw,L., Wei,W.Q., Abnet,C.C., Wang,G.Q., Roth,M.J., Liu,B., Lu,N., Giffen,C., Qiao,Y.L. and Dawsey,S.M.
    Serum pepsinogens and risk of esophageal squamous dysplasia
    Int J Cancer124, 456-460. PubMed  Europe PubMed DOI
  113. 2008
  114. Frydlova,J., Kucerova,Z. and Ticha,M.
    Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose
    J Chromatogr B Analyt Technol Biomed Life Sci863, 135-140. PubMed  Europe PubMed DOI
  115. Frydlova,J., Ticha,M. and Kucerova,Z.
    Optimization of affinity chromatography of pepsins on iodinated L-tyrosine-Sepharose
    Chromatographia67, S41-S45. DOI
  116. Hamuro,Y., Coales,S.J., Molnar,K.S., Tuske,S.J. and Morrow,J.A.
    Specificity of immobilized porcine pepsin in H/D exchange compatible conditions
    Rapid Commun Mass Spectrom22, 1041-1046. PubMed  Europe PubMed DOI  P
  117. Ito,H., Hirono,T., Morita,Y., Nemoto,Y., Kim,Y.T. and Takahashi,K.
    Novel peptide-based pepsin inhibitors containing an epoxide group
    J Enzyme Inhib Med Chem23, 352-356. PubMed  Europe PubMed DOI  I
  118. Jin,K.S., Rho,Y., Kim,J., Kim,H., Kim,I.J. and Ree,M.
    Synchrotron small-angle X-ray scattering studies of the structure of porcine pepsin under various pH conditions
    J Phys Chem B112, 15821-15827. PubMed  Europe PubMed DOI  S
  119. Ordonez,G.R., Hillier,L.W., Warren,W.C., Grutzner,F., Lopez-Otin,C. and Puente,X.S.
    Loss of genes implicated in gastric function during platypus evolution
    Genome Biol9, R81-R81. PubMed  Europe PubMed DOI
  120. 2007
  121. Cosgrove,S., Rogers,L., Hewage,C.M. and Malthouse,J.P.
    NMR study of the inhibition of pepsin by glyoxal inhibitors: mechanism of tetrahedral intermediate stabilization by the aspartyl proteases
    Biochemistry46, 11205-11215. PubMed  Europe PubMed DOI  I
  122. Roncal,T., Oviedo,A., Lopez de Armentia,I., Fernandez,L. and Villaran,M.C.
    High yield production of monomer-free chitosan oligosaccharides by pepsin catalyzed hydrolysis of a high deacetylation degree chitosan
    Carbohydr Res342, 2750-2756. PubMed  Europe PubMed DOI
  123. Sinkovits,A.F., Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    Understanding the structure-function role of specific catalytic residues in a model food related enzyme: pepsin
    Enzyme Microb Technol40, 1175-1180. DOI
  124. Zavros,Y., Waghray,M., Tessier,A., Bai,L., Todisco,A., Gumucio,L., Samuelson,L.C., Dlugosz,A. and Merchant,J.L.
    Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation
    J Biol Chem282, 33265-33274. PubMed  Europe PubMed DOI
  125. 2006
  126. [YEAR:28-11-2006]Dee,D., Pencer,J., Nieh,M.P., Krueger,S., Katsaras,J. and Yada,R.Y.
    Comparison of solution structures and stabilities of native, partially unfolded and partially refolded pepsin
    Biochemistry45, 13982-13992. PubMed  Europe PubMed DOI
  127. [YEAR:10-8-2006]Kumar,A. and Rao,M.
    Biochemical characterization of a low molecular weight aspartic protease inhibitor from thermo-tolerant Bacillus licheniformis: kinetic interactions with pepsin
    Biochim Biophys Acta1760, 1845-1856. PubMed  Europe PubMed DOI  I
  128. [YEAR:20-3-2006]Malik,A., Rudolph,R. and Sohling,B.
    A novel fusion protein system for the production of native human pepsinogen in the bacterial periplasm
    Protein Expr Purif47, 662-671. PubMed  Europe PubMed DOI  E
  129. Nagahama,K., Yamato,M., Nishio,H. and Takeuchi,K.
    Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats
    Dig Dis Sci51, 303-309. PubMed  Europe PubMed DOI  I
  130. Narita,Y., Oda,S. and Kageyama,T.
    Rodent monophyly deduced from the unique gastric proteinase constitution and molecular phylogenetic analyses using pepsinogen-C cDNA sequences
    Comp Biochem Physiol Part D Genomics Proteomics1, 273-282. PubMed  Europe PubMed DOI
  131. Roberts,N.B.
    Review article: human pepsins - their multiplicity, function and role in reflux disease
    Aliment Pharmacol Ther24 Suppl 2, 2-9. PubMed  Europe PubMed DOI  V
  132. 2005
  133. [YEAR:29-8-2005]Ibrahim,H.R., Inazaki,D., Abdou,A., Aoki,T. and Kim,M.
    Processing of lysozyme at distinct loops by pepsin: a novel action for generating multiple antimicrobial peptide motifs in the newborn stomach
    Biochim Biophys Acta1726, 102-114. PubMed  Europe PubMed DOI
  134. [YEAR:17-6-2005]Kesavulu,M.M., Ramasubramanian,S. and Suguna,K.
    Effect of dimethyl sulphoxide on the crystal structure of porcine pepsin
    Biochem Biophys Res Commun331, 1510-1514. PubMed  Europe PubMed DOI  S
  135. Kurokawa,T., Uji,S. and Suzuki,T.
    Identification of pepsinogen gene in the genome of stomachless fish, Takifugu rubripes
    Comp Biochem Physiol B Biochem Mol Biol140, 133-140. PubMed  Europe PubMed DOI
  136. [YEAR:19-8-2005]Novotna,L., Hruby,M., Benes,M.J. and Kucerova,Z.
    Affinity chromatography of porcine pepsin A using quinolin-8-ol as ligand
    J Chromatogr A1084, 108-112. PubMed  Europe PubMed DOI
  137. [YEAR:16-9-2005]Yamato,M., Nagahama,K., Kotani,T., Kato,S. and Takeuchi,K.
    Biphasic effect of prostaglandin E2 in a rat model of esophagitis mediated by EP1 receptors: relation to pepsin secretion
    Digestion72, 109-118. PubMed  Europe PubMed DOI  I
  138. 2004
  139. [YEAR:21-7-2004]Carginale,V., Trinchella,F., Capasso,C., Scudiero,R. and Parisi,E.
    Gene amplification and cold adaptation of pepsin in Antarctic fish. A possible strategy for food digestion at low temperature
    Gene336, 195-205. PubMed  Europe PubMed DOI
  140. [YEAR:5-2-2004]Frydlova,J., Kucerova,Z. and Ticha,M.
    Affinity chromatography of porcine pepsin and pepsinogen using immobilized ligands derived from the specific substrate for this enzyme
    J Chromatogr B Analyt Technol Biomed Life Sci800, 109-114. PubMed  Europe PubMed DOI
  141. [YEAR:7-12-2004]Kageyama,T.
    Role of S'1 loop residues in the substrate specificities of pepsin A and chymosin
    Biochemistry43, 15122-15130. PubMed  Europe PubMed DOI  P
  142. Munoz,R., Garcia,J.L., Carrascosa,A.V. and Gonzalez,R.
    Cloning of the authentic bovine gene encoding pepsinogen A and its expression in microbial cells
    Appl Environ Microbiol70, 2588-2595. PubMed  Europe PubMed DOI
  143. [YEAR:22-10-2004]Tanaka,T. and Yada,R.Y.
    Redesign of catalytic center of an enzyme: aspartic to serine proteinase
    Biochem Biophys Res Commun323, 947-953. PubMed  Europe PubMed DOI
  144. Tang,J.
    Pepsin A
    [ISSN:0-12-079610-4]2, 19-28.  V
  145. Tress,U., Steiner,J.M., Ruaux,C.G., Suchodolski,J.S. and Williams,D.A.
    Purification and partial characterization of feline pepsinogen
    Am J Vet Res65, 1195-1199. PubMed  Europe PubMed DOI
  146. [YEAR:23-12-2004]Yoshimasu,M.A., Tanaka,T., Ahn,J.K. and Yada,R.Y.
    Effect of N-linked glycosylation on the aspartic proteinase porcine pepsin expressed from Pichia pastoris
    Glycobiology14, 417-429. PubMed  Europe PubMed DOI  E
  147. 2003
  148. [YEAR:18-11-2003]Bryksa,B.C., Tanaka,T. and Yada,R.Y.
    N-terminal modifications increase the neutral-pH stability of pepsin
    Biochemistry42, 13331-13338. PubMed  Europe PubMed DOI
  149. [YEAR:13-3-2003]Campos,L.A. and Sancho,J.
    The active site of pepsin is formed in the intermediate conformation dominant at mildly acidic pH
    FEBS Lett538, 89-95. PubMed  Europe PubMed DOI
  150. [YEAR:1-5-2003]da Silva Gomes,R.A., Batista,R.P., Costa de Almeida,A., da Fonseca,D.N., Juliano,L. and Hial,V.
    A fluorimetric method for the determination of pepsin activity
    Anal Biochem316, 11-14. PubMed  Europe PubMed DOI  A
  151. Kamatari,Y.O., Dobson,C.M. and Konno,T.
    Structural dissection of alkaline-denatured pepsin
    Protein Sci12, 717-724. PubMed  Europe PubMed DOI
  152. Roberts,N.B. and Taylor,W.H.
    Comparative pepstatin inhibition studies on individual human pepsins and pepsinogens 1, 3 and 5 (gastricsin) and pig pepsin A
    J Enzyme Inhib Med Chem18, 209-217. PubMed  Europe PubMed DOI  I
  153. 2002
  154. Athaudaa,S.B. and Takahashia,K.
    Cleavage specificities of aspartic proteinases toward oxidized insulin B chain at different pH values
    Protein Pept Lett9, 289-294. PubMed  Europe PubMed DOI  P
  155. Fruton,J.S.
    A history of pepsin and related enzymes
    Q Rev Biol77, 127-147. PubMed  Europe PubMed DOI  V
  156. Yoshimasu,M.A., Ahn,J.K., Tanaka,T. and Yada,R.Y.
    Soluble expression and purification of porcine pepsinogen from Pichia pastoris
    Protein Expr Purif25, 229-236. PubMed  Europe PubMed DOI  E
  157. 2001
  158. Canduri,F., Teodoro,L.G.V.L., Fadel,V., Lorenzi,C.C.B., Hial,V., Gomes,R.A.S., Neto,J.R. and de Azevedo,W.F.
    Structure of human uropepsin at 2.45 A resolution
    Acta Crystallogr D Biol Crystallogr57, 1560-1570. PubMed  Europe PubMed DOI
  159. Tanaka,T. and Yada,R.Y.
    N-terminal portion acts as an initiator of the inactivation of pepsin at neutral pH
    Protein Eng14, 669-674. PubMed  Europe PubMed
  160. 2000
  161. Bhatt,D. and Dunn,B.M.
    Chimeric aspartic proteinases and active site binding
    Bioorg Chem28, 374-393. PubMed  Europe PubMed DOI
  162. Fujinaga,M., Cherney,M.M., Tarasova,N.I., Bartlett,P.A., Hanson,J.E. and James,M.N.
    Structural study of the complex between human pepsin and a phosphorus-containing peptidic-transition-state analog
    Acta Crystallogr D Biol Crystallogr56, 272-279. PubMed  Europe PubMed DOI  S  I
  163. Galea,C.A., Dalrymple,B.P., Kuypers,R. and Blakeley,R.
    Modification of the substrate specificity of porcine pepsin for the enzymatic production of bovine hide gelatin
    Protein Sci9, 1947-1959. PubMed  Europe PubMed DOI
  164. Gritti,I., Banfi,G. and Roi,G.S.
    Pepsinogens: physiology, pharmacology pathophysiology and exercise
    Pharmacol Res41, 265-281. PubMed  Europe PubMed DOI  V
  165. Kageyama,T.
    New World monkey pepsinogens A and C, and prochymosins. Purification, characterization of enzymatic properties, cDNA cloning, and molecular evolution
    J Biochem127, 761-770. PubMed  Europe PubMed
  166. Majercakova,P., Kucerova,Z., Desvaux,F.X. and Peltre,G.
    Electrotitration curves of human gastric pepsinogens in agarose gels
    Electrophoresis21, 2919-2924. PubMed  Europe PubMed DOI
  167. Mertz,H.R., Peterson,W.L. and Walsh,J.H.
    "Familial hyperpepsinogenemia" and Helicobacter pylori infection
    Am J Gastroenterol95, 943-946. PubMed  Europe PubMed DOI
  168. Narita,Y., Oda,S.I., Takenaka,W. and Kageyama,T.
    Gastric digestive proteinases of the greater horseshoe bat, Rhinolophus ferrumequinum
    Mammal Study25, 17-26.
  169. Narita,Y., Oda,S., Takenaka,O. and Kageyama,T.
    Multiplicities and some enzymatic characteristics of ape pepsinogens and pepsins
    J Med Primatol29, 402-410. PubMed  Europe PubMed
  170. Ng,K.K., Petersen,J.F., Cherney,M.M., Garen,C., Zalatoris,J.J., Rao-Naik,C., Dunn,B.M., Martzen,M.R., Peanasky,R.J. and James,M.N.
    Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3
    Nat Struct Biol7, 653-657. PubMed  Europe PubMed DOI  E  S
  171. [YEAR:1-7-2000]Okoniewska,M., Tanaka,T. and Yada,R.Y.
    The pepsin residue glycine-76 contributes to active-site loop flexibility and participates in catalysis
    Biochem J349, 169-177. PubMed  Europe PubMed DOI
  172. 1999
  173. Okoniewska,M., Tanaka,T. and Yada,R.Y.
    The role of the flap residue, threonine 77, in the activation and catalytic activity of pepsin A
    Protein Eng12, 55-61. PubMed  Europe PubMed
  174. Richter,C., Tanaka,T., Koseki,T. and Yada,R.Y.
    Contribution of a prosegment lysine residue to the function and structure of porcine pepsinogen A and its active form pepsin A
    Eur J Biochem261, 746-752. PubMed  Europe PubMed DOI
  175. 1998
  176. Aoki,T., Tomaki,E., Satoh,M., Takashiro,M., Onagi,H., Itoh,M., Teramoto,T., Morikawa,J. and Watabe,H.
    Purification of recombinant human pepsinogens and their application as immunoassay standards
    Biochem Mol Biol Int45, 289-301. PubMed  Europe PubMed  E
  177. Bateman,K.S., Chernaia,M.M., Tarasova,N.I. and James,M.N.
    Crystal structure of human pepsinogen A
    Adv Exp Med Biol436, 259-263. PubMed  Europe PubMed  S
  178. [YEAR:18-9-1998]Cho,Y.K. and Northrop,D.B.
    Transpeptidation by porcine pepsin catalyzed by a noncovalent intermediate unique to its iso-mechanism
    J Biol Chem273, 24305-24308. PubMed  Europe PubMed DOI
  179. Khan,A.R. and James,M.N.
    Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
    Protein Sci7, 815-836. PubMed  Europe PubMed DOI
  180. Litvinova,O.V., Balandina,G.N. and Stepanov,V.M.
    [Determination of activity of aspartic proteinases by cleavage of new chromogenic substrates]
    Bioorg Khim24, 175-178. PubMed  Europe PubMed  A
  181. [YEAR:1-11-1998]Richter,C., Tanaka,T. and Yada,R.Y.
    Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin
    Biochem J335, 481-490. PubMed  Europe PubMed
  182. 1997
  183. Heim,H.K., Piller,M., Schwede,J., Kilian,P., Netz-Piepenbrink,S. and Sewing,K.F.
    Pepsinogen synthesis during long-term culture of porcine chief cells
    Biochim Biophys Acta1359, 35-47. PubMed  Europe PubMed DOI
  184. Iliadis,G., Zundel,G. and Brzezinski,B.
    Catalytic mechanism of the aspartate proteinase pepsin A: an FTIR study
    Biospectroscopy3, 291-297.  I
  185. Shintani,T., Nomura,K. and Ichishima,E.
    Engineering of porcine pepsin. Alteration of S1 substrate specificity of pepsin to those of fungal aspartic proteinases by site-directed mutagenesis
    J Biol Chem272, 18855-18861. PubMed  Europe PubMed DOI
  186. 1996
  187. Bartlett,P.A. and Giangiordano,M.A.
    Transition state analogy of phosphonic acid peptide inhibitors of pepsin
    J Org Chem61, 3433-3438.  I
  188. Filippova,I.Y., Lysogorskaya,E.N., Anisimova,V.V., Suvorov,L.I., Oksenoit,E.S. and Stepanov,V.M.
    Fluorogenic peptide substrates for assay of aspartyl proteinases
    Anal Biochem234, 113-118. PubMed  Europe PubMed DOI  A
  189. Popov,E.M., Kashparov,I.V. and Popov,M.E.
    [Mechanism of aspartic proteinase action. I. Theory and method]
    Bioorg Khim22, 323-338. PubMed  Europe PubMed
  190. Tanji,M., Yakabe,E., Kageyama,T. and Takahashi,K.
    The primary structure of the major pepsinogen from the gastric mucosa of tuna stomach
    J Biochem120, 647-656. PubMed  Europe PubMed
  191. 1995
  192. Cottrell,T.J., Harris,L.J., Tanaka,T. and Yada,R.Y.
    The sole lysine residue in porcine pepsin works as a key residue for catalysis and conformational flexibility
    J Biol Chem270, 19974-19978. PubMed  Europe PubMed DOI
  193. Foltmann,B., Harlow,K., Houen,G., Nielsen,P.K. and Sangild,P.
    Comparative investigations on pig gastric proteases and their zymogens
    Adv Exp Med Biol362, 41-51. PubMed  Europe PubMed
  194. Fujinaga,M., Chernaia,M.M., Tarasova,N.I., Mosimann,S.C. and James,M.N.
    Crystal structure of human pepsin and its complex with pepstatin
    Protein Sci4, 960-972. PubMed  Europe PubMed DOI  S  I
  195. Miki,K., Ichinose,M., Kakei,N., Yahagi,N., Matsushima,M., Tsukada,S., Ishihama,S., Shimizu,Y., Suzuki,T. and Kurokawa,K.
    The clinical application of the serum pepsinogen I and II levels as a mass screening method for gastric cancer
    Adv Exp Med Biol362, 139-143. PubMed  Europe PubMed
  196. Roberts,N.B., Peek,K., Keen,J.N. and Taylor,W.H.
    Five human gastric aspartic proteinases: N-terminal amino acid sequences and amino acid composition
    Int J Biochem Cell Biol27, 133-137. PubMed  Europe PubMed DOI
  197. Tarasova,N., Denslow,N.D., Parten,B.F., Tran,N., Nhuyen,H.P., Jones,A., Roberts,N.B. and Dunn,B.M.
    A comparative study on amino acid sequences of three major isoforms of human pepsin A
    Adv Exp Med Biol362, 77-81. PubMed  Europe PubMed
  198. 1993
  199. [YEAR:27-8-1993]Jones,A.T., Keen,J.N. and Roberts,N.B.
    Human pepsin 3b peptide map sequence analysis, genotype and hydrophobic nature
    J Chromatogr646, 207-212. PubMed  Europe PubMed DOI
  200. Lin,X., Loy,J.A., Sussman,F. and Tang,J.
    Conformational instability of the N- and C-terminal lobes of porcine pepsin in neutral and alkaline solutions
    Protein Sci2, 1383-1390. PubMed  Europe PubMed DOI
  201. [YEAR:25-9-1993]Lin,X., Tang,J., Koelsch,G., Monod,M. and Foundling,S.
    Recombinant canditropsin, an extracellular aspartic protease from yeast Candida tropicalis. Escherichia coli expression, purification, zymogen activation, and enzymic properties
    J Biol Chem268, 20143-20147. PubMed  Europe PubMed
  202. [YEAR:1-5-1993]Meijerink,P.H., Bebelman,J.P., Oldenburg,A.M., Defize,J., Planta,R.J., Eriksson,A.W., Pals,G. and Mager,W.H.
    Gastric chief cell-specific transcription of the pepsinogen A gene
    Eur J Biochem213, 1283-1296. PubMed  Europe PubMed DOI
  203. [YEAR:1-10-1993]Nielsen,F.S. and Foltmann,B.
    Activation of porcine pepsinogen A. The stability of two non-covalent activation intermediates at pH 8.5
    Eur J Biochem217, 137-142. PubMed  Europe PubMed DOI
  204. 1992
  205. Carraway,R.E., Mitra,S.P. and Salmonsen,R.
    Pepsin-mediated processing of synthetic precursor-like sequence yields neurotensin-like peptide
    Peptides13, 319-322. PubMed  Europe PubMed DOI
  206. Jones,A.T. and Roberts,N.B.
    Peptide maps of five human pepsin isoenzymes and other aspartic proteinases
    J Chromatogr599, 179-184. PubMed  Europe PubMed DOI
  207. [YEAR:25-8-1992]Lin,X.L., Lin,Y.Z., Koelsch,G., Gustchina,A., Wlodawer,A. and Tang,J.
    Enzymic activities of two-chain pepsinogen, two-chain pepsin, and the amino-terminal lobe of pepsinogen
    J Biol Chem267, 17257-17263. PubMed  Europe PubMed
  208. 1991
  209. Abad-Zapatero,C., Rydel,T.J., Neidhart,D.J., Luly,J. and Erickson,J.W.
    Inhibitor binding induces structural changes in porcine pepsin
    Adv Exp Med Biol306, 9-21. PubMed  Europe PubMed  S
  210. Andreeva,N.S. and James,M.N.
    Why does pepsin have a negative charge at very low pH? An analysis of conserved charged residues in aspartic proteinases
    Adv Exp Med Biol306, 39-45. PubMed  Europe PubMed
  211. Martzen,M.R., McMullen,B.A., Fujikawa,K. and Peanasky,R.J.
    Aspartic protease inhibitors from the parasitic nematode Ascaris
    Adv Exp Med Biol306, 63-73. PubMed  Europe PubMed
  212. Meldal,M. and Breddam,K.
    Anthranilamide and nitrotyrosine as a donor-acceptor pair in internally quenched fluorescent substrates for endopeptidases: multicolumn peptide synthesis of enzyme substrates for subtilisin Carlsberg and pepsin
    Anal Biochem195, 141-147. PubMed  Europe PubMed
  213. Sielecki,A.R., Fujinaga,M., Read,R.J. and James,M.N.
    Refined structure of porcine pepsinogen at 1.8 A resolution
    J Mol Biol219, 671-692. PubMed  Europe PubMed DOI  S
  214. Smith,L.J. and Yada,Y.R.
    Chemical modification of amino groups in Mucor miehei aspartyl proteinase, porcine pepsin, and chymosin. II. Conformational stability
    Agric Biol Chem55, 2017-2024. DOI
  215. Smith,L.J., Billings,E.G. and Yada,Y.R.
    Chemical modification of amino groups in Mucor miehei aspartyl proteinase, porcine pepsin, and chymosin. I. Structure and function
    Agric Biol Chem55, 2009-2016. DOI
  216. 1990
  217. Abad-Zapatero,C., Rydel,T.J. and Erickson,J.
    Revised 2.3 A structure of porcine pepsin: evidence for a flexible subdomain
    Proteins8, 62-81. PubMed  Europe PubMed DOI  S
  218. [YEAR:1-5-1990]Baxter,A., Campbell,C.J., Grinham,C.J., Keane,R.M., Lawton,B.C. and Pendlebury,J.E.
    Substrate and inhibitor studies with human gastric aspartic proteinases
    Biochem J267, 665-669. PubMed  Europe PubMed
  219. [YEAR:5-7-1990]Cooper,J.B., Khan,G., Taylor,G., Tickle,I.J. and Blundell,T.L.
    X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution
    J Mol Biol214, 199-222. PubMed  Europe PubMed DOI  S
  220. [YEAR:5-10-1990]Kageyama,T., Tanabe,K. and Koiwai,O.
    Structure and development of rabbit pepsinogens. Stage-specific zymogens, nucleotide sequences of cDNAs, molecular evolution, and gene expression during development
    J Biol Chem265, 17031-17038. PubMed  Europe PubMed
  221. 1989
  222. Athauda,S.B., Tanji,M., Kageyama,T. and Takahashi,K.
    A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins
    J Biochem106, 920-927. PubMed  Europe PubMed
  223. Bebelman,J.P., Evers,M.P., Zelle,B., Bank,R., Pronk,J.C., Meuwissen,S.G., Mager,W.H., Planta,R.J., Eriksson,A.W. and Frants,R.R.
    Family and population studies on the human pepsinogen A multigene family
    Hum Genet82, 142-146. PubMed  Europe PubMed  M
  224. Evers,M.P., Zelle,B., Bebelman,J.P., van Beusechem,V., Kraakman,L., Hoffer,M.J., Pronk,J.C., Mager,W.H., Planta,R.J. and Eriksson,A.W.
    Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family
    Genomics4, 232-239. PubMed  Europe PubMed  M
  225. Kageyama,T., Ichinose,M., Miki,K., Athauda,S.B., Tanji,M. and Takahashi,K.
    Difference of activation processes and structure of activation peptides in human pepsinogens A and progastricsin
    J Biochem105, 15-22. PubMed  Europe PubMed
  226. Lin,X.L., Wong,R.N. and Tang,J.
    Synthesis, purification, and active site mutagenesis of recombinant porcine pepsinogen
    J Biol Chem264, 4482-4489. PubMed  Europe PubMed
  227. Samloff,I.M.
    Peptic ulcer: the many proteinases of aggression
    Gastroenterology96, 586-595. PubMed  Europe PubMed
  228. 1988
  229. Bank,R.A., Crusius,B.C., Zwiers,T., Meuwissen,S.G., Arwert,F. and Pronk,J.C.
    Identification of a Glu > Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C
    FEBS Lett238, 105-108. PubMed  Europe PubMed
  230. Basson,M.D. and Modlin,I.M.
    Pepsinogen: biological and pathophysiologic significance
    J Surg Res44, 82-97. PubMed  Europe PubMed
  231. Foltmann,B.
    Activation of human pepsinogens
    FEBS Lett241, 69-72. PubMed  Europe PubMed DOI
  232. Pohl,J. and Dunn,B.M.
    Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site
    Biochemistry27, 4827-4834. PubMed  Europe PubMed
  233. [YEAR:30-5-1988]Tsukagoshi,N., Ando,Y., Tomita,Y., Uchida,R., Takemura,T., Sasaki,T., Yamagata,H., Udaka,S., Ichihara,Y. and Takahashi,K.
    Nucleotide sequence and expression in Escherichia coli of cDNA of swine pepsinogen: involvement of the amino-terminal portion of the activation peptide segment in restoration of the functional protein
    Gene65, 285-292. PubMed  Europe PubMed
  234. Zelle,B., Evers,M.P.J., Groot,P.C., Bebelman,J.P., Mager,W.H., Planta,R.J., Pronk,J.C., Meuwissen,S.G.M., Hofker,M.H., Eriksson,A.W. and Frants,R.R.
    Genomic structure and evolution of the human pepsinogen A multigene family
    Hum Genet78, 79-82. PubMed  Europe PubMed
  235. 1987
  236. Dunn,B.M., Valler,M.J., Rolph,C.E., Foundling,S.I., Jimenez,M. and Kay,J.
    The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2
    Biochim Biophys Acta913, 122-130. PubMed  Europe PubMed
  237. Samloff,I.M. and Taggart,R.T.
    Pepsinogens, pepsins, and peptic ulcer
    Clin Invest Med10, 215-221. PubMed  Europe PubMed
  238. Taggart,R.T. and Samloff,I.M.
    Immunochemical, electrophoretic, and genetic heterogeneity of pepsinogen I. Characterization with monoclonal antibodies
    Gastroenterology92, 143-150. PubMed  Europe PubMed  M
  239. [YEAR:1-3-1987]Westerveld,B.D., Pals,G., Lamers,C.B., Defize,J., Pronk,J.C., Frants,R.R., Ooms,E.C., Kreuning,J., Kostense,P.J. and Eriksson,A.W.
    Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels
    Cancer59, 952-958. PubMed  Europe PubMed
  240. 1986
  241. Auer,H.E., Glick,D.M., James,M.N.G. and Sielecki,A.
    The mechanism of activation of porcine pepsinogen
    Nature322, 664-664. PubMed  Europe PubMed DOI
  242. [YEAR:1-8-1986]Dunn,B.M., Jimenez,M., Parten,B.F., Valler,M.J., Rolph,C.E. and Kay,J.
    A systematic series of synthetic chromophoric substrates for aspartic proteinases
    Biochem J237, 899-906. PubMed  Europe PubMed
  243. [YEAR:22-4-1986]Glick,D.M., Auer,H.E., Rich,D.H., Kawai,M. and Kamath,A.
    Pepsinogen activation: genesis of the binding site
    Biochemistry25, 1858-1864. PubMed  Europe PubMed
  244. Kucerova,Z., Pohl,J. and Korbova,L.
    Separation of human pepsin and gastricsin by affinity chromatography with an immobilized synthetic inhibitor
    J Chromatogr B Biomed Sci Appl376, 409-412. PubMed  Europe PubMed  I
  245. Nakai,H., Byers,M.G., Shows,T.B. and Taggart,R.T.
    Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization
    Cytogenet Cell Genet43, 215-217. PubMed  Europe PubMed
  246. Taggart,R.T., Samloff,I.M., Raffel,L.J., Graham,A., Cass,C., Petersen,G.M., Rotter,J.I., Skolnick,M.H., Schwartz,C.E. and Bell,G.I.
    Relationships between the human pepsinogen DNA and protein polymorphisms
    Am J Hum Genet38, 848-854. PubMed  Europe PubMed  M
  247. 1985
  248. Kostka,V., Pichova,I. and Baudys,M.
    Isolation and molecular characterization of avian pepsins
    53-72.
  249. Taggart,R.T., Mohandas,T.K., Shows,T.B. and Bell,G.I.
    Variable numbers of pepsinogen genes are located in the centromeric region of human chromosome 11 and determine the high-frequency electrophoretic polymorphism
    Proc Natl Acad Sci U S A82, 6240-6244. PubMed  Europe PubMed
  250. 1984
  251. Dodson,G. and Chothia,C.
    Fifty years of pepsin crystals
    Nature309, 309-309. PubMed  Europe PubMed DOI
  252. Dunn,B.M., Kammermann,B. and McCurry,K.R.
    The synthesis, purification, and evaluation of a chromophoric substrate for pepsin and other aspartyl proteases: design of a substrate based on subsite preferences
    Anal Biochem138, 68-73. PubMed  Europe PubMed  A
  253. [YEAR:23-10-1984]Dunn,B.M. and Fink,A.L.
    Cryoenzymology of porcine pepsin
    Biochemistry23, 5241-5247. PubMed  Europe PubMed
  254. 1983
  255. Kageyama,T. and Takahashi,K.
    Occurrence of two different pathways in the activation of porcine pepsinogen to pepsin
    J Biochem93, 743-754. PubMed  Europe PubMed
  256. Sogawa,K., Fujii-Kuriyama,Y., Mizukami,Y., Ichihara,Y. and Takahashi,K.
    Primary structure of human pepsinogen gene
    J Biol Chem258, 5306-5311. PubMed  Europe PubMed
  257. 1981
  258. Foltmann,B.
    Gastric proteinases - structure, function, evolution and mechanism of action
    Essays Biochem17, 52-84. PubMed  Europe PubMed
  259. Kostka,V., Keilova,H. and Baudys,M.
    Chicken pepsin: structure and homology with other acid proteinases
    125-140.
  260. 1980
  261. Rich,D.H. and Sun,E.T.
    Mechanism of inhibition of pepsin by pepstatin. Effect of inhibitor structure on dissociation constant and time-dependent inhibition
    Biochem Pharmacol29, 2205-2212. PubMed  Europe PubMed DOI  I
  262. 1979
  263. Roberts,N.B. and Taylor,W.H.
    Action of human pepsins 1, 2, 3 and 5 on the oxidized B-chain of insulin
    Biochem J179, 183-189. PubMed  Europe PubMed  P
  264. 1978
  265. Antonov,V.K., Ginodman,L.M., Kapitannikov,Y.V., Barshevskaya,T.N., Gurova,A.G. and Rumsh,L.D.
    Mechanism of pepsin catalysis: general base catalysis by the active-site carboxylate ion
    FEBS Lett88, 87-90. PubMed  Europe PubMed DOI
  266. Butler,J.E. and Kennedy,N.
    The differential enzyme susceptibility of bovine immunoglobulin G1 and immunglobulin G2 to pepsin and papain
    Biochim Biophys Acta535, 125-137. PubMed  Europe PubMed  P
  267. Tang,J., James,M.N., Hsu,I.N., Jenkins,J.A. and Blundell,T.L.
    Structural evidence for gene duplication in the evolution of the acid proteases
    Nature271, 618-621. PubMed  Europe PubMed
  268. 1977
  269. Fox,P.F. and Whitaker,J.R.
    Isolation and characterization of sheep pepsin
    Biochem J161, 389-398. PubMed  Europe PubMed
  270. [YEAR:23-8-1977]Harish Kumar,P.M. and Kassell,B.
    Improved pepsin inhibitor derived from activation peptide 1-16 of porcine pepsinogen
    Biochemistry16, 3846-3849. PubMed  Europe PubMed  I
  271. Powers,J.C., Harley,A.D. and Myers,D.V.
    Subsite specificity of porcine pepsin
    Adv Exp Med Biol95, 141-157. PubMed  Europe PubMed  P
  272. 1976
  273. Fruton,J.S.
    The mechanism of the catalytic action of pepsin and related acid proteinases
    Adv Enzymol Relat Areas Mol Biol44, 1-36. PubMed  Europe PubMed
  274. [YEAR:1-8-1976]Kay,J. and Dykes,C.W.
    Interaction of pepstatin with pig pepsinogen
    Biochem J157, 499-502. PubMed  Europe PubMed  I
  275. Marciniszyn,J., Jr., Huang,J.S., Hartsuck,J.A. and Tang,J.
    Mechanism of intramolecular activation of pepsinogen. Evidence for an intermediate delta and the involvement of the active site of pepsin in the intramolecular activation of pepsinogen
    J Biol Chem251, 7095-7102. PubMed  Europe PubMed
  276. 1975
  277. Newmark,A.K. and Knowles,J.R.
    Acyl- and amino-transfer routes in pepsin-catalyzed reactions
    J Am Chem Soc97, 3557-3559.
  278. 1974
  279. Abu-Erreish,G.M. and Peanasky,R.J.
    Pepsin inhibitors from Ascaris lumbricoides. Isolation, purification, and some properties
    J Biol Chem249, 1558-1565. PubMed  Europe PubMed
  280. Abu-Erreish,G.M. and Peanasky,R.J.
    Pepsin inhibitors from Ascaris lumbricoides. Pepsin-inhibitor complex: stoichiometry of formation, dissociation, and stability of the complex
    J Biol Chem249, 1566-1571. PubMed  Europe PubMed
  281. Fruton,J.S.
    The active site of pepsin
    Acc Chem Res7, 241-246.
  282. [YEAR:25-7-1974]Harboe,M., Andersen,P.M., Foltmann,B., Kay,J. and Kassell,B.
    The activation of bovine pepsinogen. Sequence of the peptides released, identification of a pepsin inhibitor
    J Biol Chem249, 4487-4494. PubMed  Europe PubMed  I
  283. [YEAR:4-2-1974]McPhie,P.
    Pepsinogen: activation by a unimolecular mechanism
    Biochem Biophys Res Commun56, 789-792. PubMed  Europe PubMed
  284. Sampath-Kumar,P.S. and Fruton,J.S.
    Studies on the extended active sites of acid proteinases
    Proc Natl Acad Sci U S A71, 1070-1072. PubMed  Europe PubMed  P
  285. [YEAR:15-3-1974]Takahashi,M., Wang,T.T. and Hofmann,T.
    Acyl intermediates in pepsin and penicillopepsin catalyzed reactions
    Biochem Biophys Res Commun57, 39-46. PubMed  Europe PubMed
  286. 1973
  287. Sachdev,G.P., Brownstein,A.D. and Fruton,J.S.
    N-Methyl-2-anilinonaphthalene-6-sulfonyl peptides as fluorescent probes for pepsin-substrate interaction
    J Biol Chem248, 6292-6299. PubMed  Europe PubMed
  288. Tang,J., Sepulveda,P., Marciniszyn,J., Jr., Chen,K.C., Huang,W.Y., Tao,N., Liu,D. and Lanier,J.P.
    Amino-acid sequence of porcine pepsin
    Proc Natl Acad Sci U S A70, 3437-3439. PubMed  Europe PubMed
  289. 1972
  290. [YEAR:25-7-1972]al-Janabi,J., Hartsuck,J.A. and Tang,J.
    Kinetics and mechanism of pepsinogen activation
    J Biol Chem247, 4628-4632. PubMed  Europe PubMed
  291. Chen,K.C. and Tang,J.
    Amino acid sequence around the epoxide-reactive residues in pepsin
    J Biol Chem247, 2566-2574. PubMed  Europe PubMed  I
  292. Kunimoto,S., Aoyagi,T., Morishima,H., Takeuchi,T. and Umezawa,H.
    Mechanism of inhibition of pepsin by pepstatin
    J Antibiot (Tokyo)25, 251-255. PubMed  Europe PubMed  I
  293. Sachdev,G.P., Johnston,M.A. and Fruton,J.S.
    Fluorescence studies on the interaction of pepsin with its substrates
    Biochemistry11, 1080-1086. PubMed  Europe PubMed
  294. 1971
  295. Fruton,J.S.
    4. Pepsin
    Enzymes3, 119-164. DOI  V
  296. Husain,S.S., Ferguson,J.B. and Fruton,J.S.
    Bifunctional inhibitors of pepsin
    Proc Natl Acad Sci U S A68, 2765-2768. PubMed  Europe PubMed
  297. Lang,H.M. and Kassell,B.
    Bovine pepsinogens and pepsins. III. Composition and specificity of the pepsins
    Biochemistry10, 2296-2301. PubMed  Europe PubMed
  298. May,S.W. and Kaiser,E.T.
    The pH dependence of the pepsin-catalyzed hydrolysis of bis-p-nitrophenyl sulfite
    J Am Chem Soc93, 5567-5572.
  299. Meitner,P.A. and Kassell,B.
    Bovine pepsinogens and pepsins. A series of zymogens and enzymes that differ in organic phosphate content
    Biochem J121, 249-256. PubMed  Europe PubMed
  300. Nevaldine,B. and Kassell,B.
    Bovine pepsinogen and pepsin. IV. A new method of purification of pepsin
    Biochim Biophys Acta250, 207-209. PubMed  Europe PubMed
  301. Tang,J.
    Specific and irreversible inactivation of pepsin by substrate-like epoxides
    J Biol Chem246, 4510-4517. PubMed  Europe PubMed  I
  302. Voynick,I.M. and Fruton,J.S.
    The comparative specificity of acid proteinases
    Proc Natl Acad Sci U S A68, 257-259. PubMed  Europe PubMed  P
  303. 1970
  304. [YEAR:14-1-1970]Clement,G.E., Rooney,J., Zakheim,D. and Eastman,J.
    The pH dependence of the dephosphorylated pepsin-catalyzed hydrolysis of N-acetyl-L-phenylalanyl-L-tyrosine methyl ester
    J Am Chem Soc92, 186-189. PubMed  Europe PubMed
  305. Fruton,J.S.
    The specificity and mechanism of pepsin action
    Adv Enzymol Relat Areas Mol Biol33, 401-443. PubMed  Europe PubMed
  306. [YEAR:7-7-1970]Hunkapiller,M., Heinze,J.E. and Mills,J.N.
    Comparative studies on the effect of specific inactivators on human gastricsin and pepsin
    Biochemistry9, 2897-2902. PubMed  Europe PubMed
  307. Kassell,B. and Meitner,P.A.
    [21] Bovine pepsinogen and pepsin
    Methods Enzymol19, 337-347. DOI
  308. Kitson,T.M. and Knowles,J.R.
    Evidence for an acyl-pepsin intermediate: a re-appraisal
    J Chem Soc D Chem Commun1970, 361b-362. DOI
  309. Medzihradzky,K., Voynick,I.M., Medzihradszky-Schweiger,H. and Fruton,J.S.
    Effect of secondary enzyme-substrate interactions on the cleavage of synthetic peptides by pepsin
    Biochemistry9, 1154-1162. PubMed  Europe PubMed
  310. Ryle,A.P.
    [20] The porcine pepsins and pepsinogens
    Methods Enzymol19, 316-336. DOI  V
  311. Umezawa,H., Aoyagi,T., Morishima,H., Matsuzaki,M., Hamada,M. and Takeuchi,T.
    Pepstatin, a new pepsin inhibitor produced by actinomycetes
    J Antibiot (Tokyo)23, 259-262. PubMed  Europe PubMed  I
  312. 1969
  313. Bayliss,R.S., Knowles,J.R. and Wybrandt,G.B.
    An aspartic acid residue at the active site of pepsin. The isolation and sequence of the heptapeptide
    Biochem J113, 377-386. PubMed  Europe PubMed
  314. Bohak,Z.
    Purification and characterization of chicken pepsinogen and chicken pepsin
    J Biol Chem244, 4638-4648. PubMed  Europe PubMed
  315. Cornish-Bowden,A.J., Greenwell,P. and Knowles,J.R.
    The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate
    Biochem J113, 369-375. PubMed  Europe PubMed
  316. Cornish-Bowden,A.J. and Knowles,J.R.
    The pH-dependence of pepsin-catalysed reactions
    Biochem J113, 353-362. PubMed  Europe PubMed
  317. Hollands,T.R. and Fruton,J.S.
    On the mechanism of pepsin action
    Proc Natl Acad Sci U S A62, 1116-1120. PubMed  Europe PubMed
  318. Hollands,T.R., Voynick,I.M. and Fruton,J.S.
    Action of pepsin on cationic synthetic substrates
    Biochemistry8, 575-585. PubMed  Europe PubMed
  319. Huang,W.Y. and Tang,J.
    On the specificity of human gastricsin and pepsin
    J Biol Chem244, 1085-1091. PubMed  Europe PubMed
  320. Lundblad,R.L. and Stein,W.H.
    On the reaction of diazoacetyl compounds with pepsin
    J Biol Chem244, 154-160. PubMed  Europe PubMed  I
  321. May,S.W. and Kaiser,E.T.
    The pepsin-catalyzed hydrolysis of bis-p-nitrophenyl sulfite and its inhibition by diphenyl sulfite at pH 2
    J Am Chem Soc91, 6491-6495.
  322. Sachdev,G.P. and Fruton,J.S.
    Pyridyl esters of peptides as synthetic substrates of pepsin
    Biochemistry8, 4231-4238. PubMed  Europe PubMed
  323. Trout,G.E. and Fruton,J.S.
    The side-chain specificity of pepsin
    Biochemistry8, 4183-4190. PubMed  Europe PubMed
  324. 1968
  325. Hollands,T.R. and Fruton,J.S.
    Kinetics of the hydrolysis of synthetic substrates by pepsin and by acetyl-pepsin
    Biochemistry7, 2045-2053. PubMed  Europe PubMed
  326. Humphreys,R.E. and Fruton,J.S.
    The substrate binding site of pepsin
    Proc Natl Acad Sci U S A59, 519-525. PubMed  Europe PubMed
  327. Keilova,H., Blaha,K. and Keil,B.
    Effect of steric factors on digestibility of peptides containing aromatic amino acids by cathepsin D and pepsin
    Eur J Biochem4, 442-447. PubMed  Europe PubMed  P
  328. Schlamowitz,M., Shaw,A. and Jackson,W.T.
    The nature of the binding of inhibitors to pepsin and the kinetics of inhibited peptic hydrolysis of N-acetyl-L-phenylalanyl-L-tyrosine
    J Biol Chem243, 2821-2828. PubMed  Europe PubMed
  329. Stein,T.P. and Fahrney,D.
    The pepsin-catalysed hydrolysis of sulphite esters. Oxygen-18 studies providing direct evidence for involvement of a carboxyl group in sulphite esterase activity
    Chem Commun (London)1968, 555-556. DOI
  330. 1967
  331. Inouye,K. and Fruton,J.S.
    Studies on the specificity of pepsin
    Biochemistry6, 1765-1777. PubMed  Europe PubMed
  332. Lee,D. and Ryle,A.P.
    Pepsin D. A minor component of commercial pepsin preparations
    Biochem J104, 742-748. PubMed  Europe PubMed
  333. Lee,D. and Ryle,A.P.
    Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa
    Biochem J104, 735-741. PubMed  Europe PubMed
  334. 1966
  335. Clement,G.E. and Snyder,S.L.
    The kinetics of the pepsin-catalyzed hydrolysis of N-acetyl-L-phenylalanyl-L-tyrosine methyl ester
    J Am Chem Soc88, 5338-5339.
  336. Delpierre,G.R. and Fruton,J.S.
    Specific inactivation of pepsin by a diazo ketone
    Proc Natl Acad Sci U S A56, 1817-1822. PubMed  Europe PubMed
  337. Jackson,W.T., Schlamowitz,M. and Shaw,A.
    Kinetics of the pepsin-catalyzed hydrolysis of N-acetyl dipeptides
    Biochemistry5, 4105-4110.
  338. Rajagopalan,T.G., Stein,W.H. and Moore,S.
    The inactivation of pepsin by diazoacetylnorleucine methyl ester
    J Biol Chem241, 4295-4297. PubMed  Europe PubMed  I
  339. Zeffren,E. and Kaiser,E.T.
    The pepsin-catalyzed hydrolysis of N-acetyl-L-phenylalanyl-L-3,5-dibromotyrosine at pH 2
    J Am Chem Soc88, 3129-3131.
  340. 1965
  341. Delpierre,G.R. and Fruton,J.S.
    Inactivation of pepsin by diphenyldiazomethane
    Proc Natl Acad Sci U S A54, 1161-1167. PubMed  Europe PubMed  I
  342. Silver,M.S., Denburg,J.L. and Steffens,J.J.
    Spectrophotometric determination of the kinetics of the pepsin-catalyzed hydrolysis of certain dipeptide substrates
    J Am Chem Soc87, 886-889. PubMed  Europe PubMed
  343. 1964
  344. Seijfeers,M.J., Miller,L.L. and Segal,H.L.
    Some observations on the conversion of three different human pepsinogens to their respective pepsins
    Biochemistry3, 1-4. PubMed  Europe PubMed
  345. Seijffers,M.J., Miller,L.L. and Segal,H.L.
    Partial characterization of human pepsin I, pepsin IIA, pepsin IIB, and pepsin III
    Biochemistry3, 1203-1209. PubMed  Europe PubMed
  346. 1963
  347. Tang,J.
    SPECIFICITY OF PEPSIN AND ITS DEPENDENCE ON A POSSIBLE 'HYDROPHOBIC BINDING SITE'
    Nature199, 1094-1095. PubMed  Europe PubMed DOI
  348. 1962
  349. Herriott,R.M.
    Pepsinogen and pepsin
    J Gen Physiol454, 57-76. PubMed  Europe PubMed
  350. 1959
  351. Taylor,W.H.
    Studies on gastric proteolysis. 1. The proteolytic activity of human gastric juice and pig and calf gastric mucosal extracts below pH 5
    Biochem J71, 73-83. PubMed  Europe PubMed
  352. 1957
  353. Van Vunakis,H. and Herriott,R.M.
    Structural changes associated with the conversion of pepsinogen to pepsin. II. The N-terminal amino acid residues of pepsin and pepsinogen; The amino acid composition of pepsinogen
    Biochim Biophys Acta23, 600-608. PubMed  Europe PubMed
  354. 1956
  355. Green,N.M.
    Action of pepsin on synthetic substrates [7]
    Nature178, 145-145. DOI
  356. Herriott,R.M.
    The active groups of pepsin
    J Cell Physiol Suppl47, 239-243. PubMed  Europe PubMed
  357. Herriott,R.M. and Van Vunakis,H.
    Structural changes associated with the conversion of pepsinogen to pepsin. I. The N-terminal amino acid residue and amino acid composition of the pepsin inhibitor
    Biochim Biophys Acta22, 537-543. PubMed  Europe PubMed
  358. 1955
  359. Herriott,R.M.
    [1] Swine pepsin and pepsinogen
    Methods Enzymol2, 3-7. DOI
  360. 1951
  361. Baker,L.E.
    New synthetic substrates for pepsin
    J Biol Chem193, 809-819. PubMed  Europe PubMed
  362. Sanger,F. and Tuppy,H.
    Amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates
    Biochem J49, 481-490. PubMed  Europe PubMed  P
  363. 1946
  364. [YEAR:20-11-1946]Northrop,J.H.
    Crystallization of pepsin from alcohol
    J Gen Physiol30, 177-184. PubMed  Europe PubMed DOI
  365. 1940
  366. [YEAR:20-3-1940]Herriott,R.M., Desreux,V. and Northrop,J.H.
    Electrophoresis of pepsin
    J Gen Physiol23, 439-447. PubMed  Europe PubMed DOI
  367. [YEAR:20-11-1940]Herriott,R.M., Desreux,V. and Northrop,J.H.
    Fractionation of pepsin: 1. Isolation of crystalline pepsin of constant activity and solubility from pepsinogen or commercial pepsin preparations. 2. Preparation of a less soluble fraction. 3. Solubility curves of mixtures of the soluble and insoluble fractions. 4. Preparation of highly active pepsin from pepsinogen
    J Gen Physiol24, 213-246. PubMed  Europe PubMed DOI
  368. 1939
  369. Fruton,J.S. and Bergmann,M.
    The specificity of pepsin
    J Biol Chem127, 627-641.
  370. [YEAR:20-9-1938]Anson,M.L.
    The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin
    J Gen Physiol22, 79-89. PubMed  Europe PubMed DOI  A
  371. 1938
  372. Herriott,R.M.
    Isolation, crystallization, and properties of swine pepsinogen
    J Gen Physiol21, 501-540. PubMed  Europe PubMed DOI
  373. [YEAR:20-5-1938]Herriott,R.M., Bartz,Q.R. and Northrop,J.H.
    TRANSFORMATION OF SWINE PEPSINOGEN INTO SWINE PEPSIN BY CHICKEN PEPSIN
    J Gen Physiol21, 575-582. PubMed  Europe PubMed DOI
  374. 1935
  375. Sherwood,I.R.
    122. The function of pepsin and rennet in the ripening of cheddar cheese
    J Dairy Res6, 407-421. DOI
  376. 1934
  377. Bernal,J.D. and Crowfoot,d.
    X-ray photographs of crystalline pepsin [3]
    Nature133, 794-795.
  378. [YEAR:20-9-1934]Herriott,R.M. and Northrop,J.H.
    Crystalline acetyl derivatives of pepsin
    J Gen Physiol18, 35-67. PubMed  Europe PubMed DOI
  379. [YEAR:20-1-1934]Northrop,J.H.
    Crystalline pepsin: VI. Inactivation by beta and gamma rays from radium and by ultra-violet light
    J Gen Physiol17, 359-363. PubMed  Europe PubMed DOI
  380. 1933
  381. Calvery,H.O.
    Crystalline egg albumin. The hydrolysis of crystalline egg albumin by pepsin, papain-hydrocyanic acid, and pancreatic proteinase and the subsequent action of some other enzymes on the hydrolysis products produced by these enzymes
    J Biol Chem102, 73-88.
  382. [YEAR:20-3-1933]Northrop,J.H.
    Crystalline pepsin: V. Isolation of crystalline pepsin from bovine gastric juice
    J Gen Physiol16, 615-623. PubMed  Europe PubMed DOI
  383. 1932
  384. [YEAR:20-9-1932]Northrop,J.H.
    Pepsin activity units and methods for determining peptic activity
    J Gen Physiol16, 41-58. PubMed  Europe PubMed DOI
  385. [YEAR:20-9-1932]Northrop,J.H.
    Crystalline pepsin: IV. Hydrolysis and inactivation by acid
    J Gen Physiol16, 33-40. PubMed  Europe PubMed DOI
  386. 1931
  387. [YEAR:20-7-1931]Northrop,J.H.
    Crystalline pepsin: III. Preparation of active crystalline pepsin from inactive denatured pepsin
    J Gen Physiol14, 713-724. PubMed  Europe PubMed DOI
  388. 1930
  389. Northrop,J.H.
    Crystalline pepsin. I. Isolation and tests of purity
    J Gen Physiol13, 739-766. PubMed  Europe PubMed DOI
  390. Northrop,J.H.
    Crystalline pepsin. II. General properties and experimental methods
    J Gen Physiol13, 767-780. PubMed  Europe PubMed DOI
  391. 1929
  392. Forbes,J.C.
    The purification of pepsin
    J Chem Educ6, 1277-1281.  V
  393. 1926
  394. Waldschmidt-Leitz,E. and Simons,E.
    Uber die Wirkungsweise des Pepsins: (Sechste Mitteilung zur Spezifitat tierischer Proteasen.)
    HOPPE-SEYLERS'S Z PHYSIOL CHEM156, 114-127. DOI
  395. [YEAR:20-5-1925]Northrop,J.H.
    A test for diffusible ions: II. The ionic nature of pepsin
    J Gen Physiol7, 603-614. PubMed  Europe PubMed DOI
  396. 1925
  397. Smorodinzew,J.A. and Adowa,A.N.
    Bereitung von Standards zur colorimetrischen Bestimmung des Pepsins
    HOPPE-SEYLERS'S Z PHYSIOL CHEM149, 173-178. DOI  A
  398. 1923
  399. Hammarsten,O.
    Studien Uber Chymosin- und Pepsinwirkung. IX. Mitteilung. Uber das Verschiedene verhalten der Magenenzyme von Kalb und Schwein gegen Saurewirkung beim Erwarmen
    HOPPE-SEYLERS'S Z PHYSIOL CHEM130, 55-71. DOI
  400. [YEAR:20-1-1923]Northrop,J.H. and Hussey,R.G.
    A method for the quantitative determination of trypsin and pepsin
    J Gen Physiol5, 353-358. PubMed  Europe PubMed DOI
  401. [YEAR:20-11-1920]Northrop,J.H.
    The significance of the hydrogen ion concentration for the digestion of proteins by pepsin
    J Gen Physiol3, 211-227. PubMed  Europe PubMed DOI
  402. [YEAR:20-5-1920]Northrop,J.H.
    The influence of hydrogen ion concentration on the inactivation of pepsin solutions
    J Gen Physiol2, 465-470. PubMed  Europe PubMed DOI
  403. [YEAR:20-7-1920]Northrop,J.H.
    The influence of the substrate concentration on the rate of hydrolysis of proteins by pepsin
    J Gen Physiol2, 595-611. PubMed  Europe PubMed DOI
  404. [YEAR:20-5-1920]Northrop,J.H.
    The effect of the concentration of enzyme on the rate of digestion of proteins by pepsin
    J Gen Physiol2, 471-498. PubMed  Europe PubMed DOI
  405. 1919
  406. Davis,L. and Merker,H.M.
    Studies on pepsin. I. Chemical changes in the purification of pepsin
    J Am Chem Soc41, 221-228.
  407. [YEAR:20-11-1919]Northrop,J.H.
    The combination of enzyme and substrate: I. A method for the quantitative determination of pepsin. II. The effect of the hydrogen ion concentration
    J Gen Physiol2, 113-122. PubMed  Europe PubMed DOI
  408. [YEAR:20-7-1919]Northrop,J.H.
    The effect of various acids on the digestion of proteins by pepsin
    J Gen Physiol1, 607-612. PubMed  Europe PubMed DOI
  409. 1918
  410. Hammarsten,O.
    Studien uber Chymosin- und Pepsinwirkung: V. Mitteilung. Wirkung der Enzyme auf Erbsenlegumine
    HOPPE-SEYLERS'S Z PHYSIOL CHEM102, 105-147. DOI
  411. Hammarsten,O.
    Studien uber Chymosin- und Pepsinwirkung: IV. Mitteilung. Die Wirkung der Enzyme auf Natriumcaseinate
    HOPPE-SEYLERS'S Z PHYSIOL CHEM102, 33-77. DOI
  412. 1916
  413. Hamburger,W.W. and Halpern,B.
    Further studies in the inactivation of pepsin: the effects of various salts and alkaline substances
    Arch Intern MedXVIII, 228-234. DOI
  414. 1911
  415. Porter,A.E.
    On the question of the identity of pepsin and rennet
    J Physiol42, 389-401. PubMed  Europe PubMed DOI
  416. 1910
  417. Rose,W.C.
    A modified method for the clinical estimation of pepsin
    Arch Intern MedV, 459-465. DOI  A
  418. 1905
  419. Sawjalow,W.
    Zur Frage nach der Identitat von Pepsin und Chymosin
    HOPPE-SEYLERS'S Z PHYSIOL CHEM46, 307-331. DOI